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Abstract Introduction Ultraviolet-free (UV-free) blue light phototherapy has emerged as a promising option due to its reported efficacy and minimal adverse effects. This study aims to evaluate the effectiveness of full-body blue light irradiation in both adult and pediatric patients with atopic dermatitis (AD), assessing its impact on skin condition and mood regulation by investigating serum concentrations of serotonin and kynurenine pathway metabolites. Methods 20 patients (age 9–45) with moderate and severe AD were included in the study. Treatment consisted of 10 irradiations with Full Body Blue device (453 nm). Serum concentrations of serotonin, quinolinic acid, kynurenic acid, tryptophan, and kynurenine were measured before and after irradiations. Results After 10 sessions of full blue light therapy (453 nm) statistically significant improvements were observed in Eczema Area Severity Index (EASI 13.16 vs. 8.65; p = 0.00016), SCORing Atopic Dermatitis (SCORAD 44.99 vs. 23.73; p

Abstract This paper presents a novel approach called Pharmacophore Activity Delta for extracting outstanding pharmacophores from a chemogenomic dataset, with a specific focus on a kinase target known as BCR-ABL. The method involves constructing a Hasse diagram, referred to as the pharmacophore network, by utilizing the subgraph partial order as an initial step, leading to the identification of pharmacophores for further evaluation. A pharmacophore is classified as a ‘Pharmacophore Activity Delta’ if its capability to effectively discriminate between active vs inactive molecules significantly deviates (by at least δ standard deviations) from the mean capability of its related pharmacophores. Among the 1479 molecules associated to BCR-ABL binding data, 130 Pharmacophore Activity Delta were identified. The pharmacophore network reveals distinct regions associated with active and inactive molecules. The study includes a discussion on representative key areas linked to different pharmacophores, emphasizing structure–activity relationships.

Current deep learning approaches are cutting-edge methods for solving classification tasks. Arising transfer learning techniques allows applying large generic model to simple tasks whereas simpler models could be used. Large models raise the major problem of their memory consumption and processor usage and lead to a prohibitive ecological footprint. In that paper, we present a novel visual analytics approach to interactively prune those networks and thus limit that issue. Our technique leverages a novel sparkline matrix visualization technique as well as a novel local metric which evaluates the discriminatory power of a filter to guide the pruning process and make it interpretable. We assess the well- founded of our approach through two realistic case studies and a user study. For both of them, the interactive refinement of the model led to a significantly smaller model having similar prediction accuracy than the original one.

The design of efficient representations is well established as a fruitful way to explore and analyze complex or large data. In these representations, data are encoded with various visual attributes depending on the needs of the representation itself. To make coherent design choices about visual attributes, the visual search field proposes guidelines based on the human brain’s perception of features. However, information visualization representations frequently need to depict more data than the amount these guidelines have been validated on. Since, the information visualization community has extended these guidelines to a wider parameter space.This paper contributes to this theme by extending visual search theories to an information visualization context. We consider a visual search task where subjects are asked to find an unknown outlier in a grid of randomly laid out distractors. Stimuli are defined by color and shape features for the purpose of visually encoding categorical data. The experimental protocol is made of a parameters space reduction step (i.e., sub-sampling) based on a machine learning model, and a user evaluation to validate hypotheses and measure capacity limits. The results show that the major difficulty factor is the number of visual attributes that are used to encode the outlier. When redundantly encoded, the display heterogeneity has no effect on the task. When encoded with one attribute, the difficulty depends on that attribute heterogeneity until its capacity limit (7 for color, 5 for shape) is reached. Finally, when encoded with two attributes simultaneously, performances drop drastically even with minor heterogeneity.

The increase of data collection in various domains calls for an adaptation of methods of visualization to tackle magnitudes exceeding the number of available pixels on screens and challenging interactivity. This growth of datasets size has been supported by the advent of accessible and scalable storage and computing infrastructure. Similarly, visualization systems need perceptual and interactive scalability. We present a complete system, complying with the constraints of aforesaid environment, for visual exploration of large multidimensional data with parallel coordinates. Perceptual scalability is addressed with data abstraction while interactions rely on server-side data-intensive computation and hardware-accelerated rendering on the client-side. The system employs a hybrid computing method to accommodate pre-computing time or space constraints and achieves responsiveness for main parallel coordinates plot interaction tools on billions of records.