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447 results on '"David C Rubinsztein"'

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1. Trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington’s disease (FELL-HD): a phase II, single-centre, open-label, dose-finding trial protocol

2. Interferon-β-induced miR-1 alleviates toxic protein accumulation by controlling autophagy

3. Functional drug screening reveals anticonvulsants as enhancers of mTOR‐independent autophagic killing of Mycobacterium tuberculosis through inositol depletion

4. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

5. Reducing Igf-1r levels leads to paradoxical and sexually dimorphic effects in HD mice.

6. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

7. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice.

8. An inducible expression system for the manipulation of autophagic flux in vivo

9. New insights into the genetic etiology of Alzheimer's disease and related dementias

10. Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration

11. SMER28 binding to VCP/p97 enhances both autophagic and proteasomal neurotoxic protein clearance

12. TMED9-SEC12, an important 'contact' for autophagy

13. Vinexin contributes to autophagic decline in brain ageing across species

15. The pleiotropic roles of autophagy in Alzheimer's disease: From pathophysiology to therapy

16. Breakthroughs and bottlenecks in autophagy research

17. Autophagy regulation by acetylation—implications for neurodegenerative diseases

18. Autophagy in Neuronal Development and Plasticity

19. Huntingtin-lowering strategies for Huntington’s disease

20. Autophagy Induction as a Therapeutic Strategy for Neurodegenerative Diseases

21. The different autophagy degradation pathways and neurodegeneration

22. Cell type-specific YAP1-WWTR1/TAZ transcriptional responses after autophagy perturbations are determined by levels of α-catenins (CTNNA1 and CTNNA3)

25. Protocol for determining the regulation of lipid kinases and changes in phospholipids

26. Autophagy in major human diseases

28. Latest advances in aging research and drug discovery

29. Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

30. Transient siRNA-mediated protein knockdown in mouse followed by feeding/starving cycle and liver tissue analysis

31. Lysosome positioning and mTOR activity in Lowe syndrome

32. Vinexin contributes to autophagic decline in brain ageing across species

33. α-Catenin levels determine direction of YAP/TAZ response to autophagy perturbation

34. AMPK-activated ULK1 phosphorylates PIKFYVE to drive formation of PtdIns5P-containing autophagosomes during glucose starvation

35. mTORC2 Assembly Is Regulated by USP9X-Mediated Deubiquitination of RICTOR

36. AMPK

37. Developing Therapies for Neurodegenerative Disorders: Insights from Protein Aggregation and Cellular Stress Responses

40. Erratum: Author Correction: Mendelian neurodegenerative disease genes involved in autophagy

41. cGMP via PKG activates 26S proteasomes and enhances degradation of proteins, including ones that cause neurodegenerative diseases

42. Leucine regulates autophagy via acetylation of the mTORC1 component raptor

43. A location, location, location mutation impairs DNM2-mediated release of nascent autophagosomes from recycling endosomes

44. IFNB/interferon-β regulates autophagy via a MIR1-TBC1D15-RAB7 pathway

45. Promoting the clearance of neurotoxic proteins in neurodegenerative disorders of ageing

46. VCP/p97 modulates PtdIns3P production and autophagy initiation

47. An open-label study to assess the feasibility and tolerability of rilmenidine for the treatment of Huntington’s disease

48. Polyglutamine tracts regulate beclin 1-dependent autophagy

49. Deadly Encounter: Endosomes Meet Mitochondria to Initiate Apoptosis

50. IFNB/interferon-β regulates autophagy via a

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