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1. The utility of pharmacological and radiological interventions to optimize diagnostic information from PET/CT

Author

David Dudoignon, David A. Pattison, Damien Legallois, Rodney J. Hicks, and Nicolas Aide

Subjects
Positron emission tomography, False-negative, Intervention, Methodology, Protocol, Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Positron Emission Tomography with Computed Tomography (PET/CT) is widely used in the assessment of many diseases, particularly including cancer. However, many factors can affect image quality and diagnostic performance of PET scans using FDG or other PET probes. Main body The aim of this pictorial essay is to review PET/CT protocols that can be useful to overcome these confounding factors in routine clinical situations, with a particular focus on pharmacological interventions and problem-oriented CT acquisition protocols. Conclusion Imaging protocols and representative cases will be discussed, in addition to potential contraindications and precautions to be taken.

Published
2020
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2. Quantification of myocardial 99mTc-labeled bisphosphonate uptake with cadmium zinc telluride camera in patients with transthyretin-related cardiac amyloidosis

Author

Alain Manrique, David Dudoignon, Stéphanie Brun, Catherine N’Ganoa, Emmanuelle Cassol, Damien Legallois, Yoan Lavie-Badie, Denis Agostini, and Olivier Lairez

Subjects
CZT SPECT, Cardiac amyloidosis, Bone scintigraphy, Planar imaging, Medical physics. Medical radiology. Nuclear medicine, R895-920
Abstract

Abstract Purpose We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR). Methods Data from 67 patients with ATTR who underwent both conventional whole-body scan and a CZT myocardial SPECT (DSPECT, Spectrum Dynamics) 3 h after injection of 99mTc-labeled bone tracer were analyzed. Visual scoring of cardiac retention was performed on whole-body scan according to Perugini 4-point grading system from 0 (no uptake) to 3 (strong cardiac uptake with mild/absent bone uptake). A planar heart-to-background (H:B) ratio was calculated using whole-body scan (wb-H:B). CZT SPECT was quantified using three methods: planar H:B ratio calculated from anterior reprojection (ant-H:B), left anterior oblique reprojection (LAO-H:B), and 3D-H:B ratio calculated from transaxial slices as mean counts in a VOI encompassing the heart divided by background VOI in the contralateral lung. Interventricular septal thickness was obtained using echocardiography. Results H:Bs obtained from planar and reprojected data were not statistically different (wb-H:B, 2.05 ± 0.64, ant-H:B, 1.97 ± 0.61, LAO-H:B, 2.06 ± 0.64, all p = ns). However, 3D-H:B was increased compared to planar H:Bs (3D-H:B, 4.06 ± 1.77, all p

Published
2019
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3. 18F-fluorocholine PET/CT and conventional imaging in primary hyperparathyroidism

Author

David Dudoignon, Thierry Delbot, Anne Ségolène Cottereau, Amina Dechmi, Marie Bienvenu, Eugénie Koumakis, Catherine Cormier, Sébastien Gaujoux, Lionel Groussin, Béatrix Cochand-Priollet, Jérome Clerc, and Myriam Wartski

Subjects
Adult, Aged, 80 and over, Male, Technetium Tc 99m Sestamibi, Radiological and Ultrasound Technology, General Medicine, Middle Aged, Hyperparathyroidism, Primary, Choline, Parathyroid Glands, Positron Emission Tomography Computed Tomography, Humans, Female, Radiology, Nuclear Medicine and imaging, Aged, Retrospective Studies
Abstract

The purpose of this study was to assess the diagnostic capabilities of preoperative conventional imaging (A total of 51 consecutive patients (6 men, 45 women; mean age, 62 ± 11.6 [SD] years; age range: 28-86 years) with biochemically confirmed PHPT who underwent CUS, single-tracer dual phaseAt surgery, 74 lesions were removed (32 parathyroid adenomas, 38 parathyroid hyperplasia and 4 subnormal glands). Thirty-six patients (71%) had single-gland disease and 15 patients (29%) had multiglandular disease at histopathological analysis. On a patient basis, sensitivity and accuracy of FCH PET/CT, CUS andOur results suggest that CUS

Published
2022

5. Quantification of myocardial 99mTc-labeled bisphosphonate uptake with cadmium zinc telluride camera in patients with transthyretin-related cardiac amyloidosis

Author

Denis Agostini, David Dudoignon, Alain Manrique, S. Brun, Catherine Nganoa, Yoan Lavie-Badie, Olivier Lairez, Emmanuelle Cassol, and Damien Legallois

Subjects
lcsh:Medical physics. Medical radiology. Nuclear medicine, medicine.medical_treatment, lcsh:R895-920, Cardiac amyloidosis, CZT SPECT, chemistry.chemical_compound, medicine, Radiology, Nuclear Medicine and imaging, In patient, Cardiac imaging, Planar imaging, medicine.diagnostic_test, biology, business.industry, Amyloidosis, Bisphosphonate, medicine.disease, Cadmium zinc telluride, Transthyretin, Bone scintigraphy, chemistry, biology.protein, Nuclear medicine, business
Abstract

Purpose We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR). Methods Data from 67 patients with ATTR who underwent both conventional whole-body scan and a CZT myocardial SPECT (DSPECT, Spectrum Dynamics) 3 h after injection of 99mTc-labeled bone tracer were analyzed. Visual scoring of cardiac retention was performed on whole-body scan according to Perugini 4-point grading system from 0 (no uptake) to 3 (strong cardiac uptake with mild/absent bone uptake). A planar heart-to-background (H:B) ratio was calculated using whole-body scan (wb-H:B). CZT SPECT was quantified using three methods: planar H:B ratio calculated from anterior reprojection (ant-H:B), left anterior oblique reprojection (LAO-H:B), and 3D-H:B ratio calculated from transaxial slices as mean counts in a VOI encompassing the heart divided by background VOI in the contralateral lung. Interventricular septal thickness was obtained using echocardiography. Results H:Bs obtained from planar and reprojected data were not statistically different (wb-H:B, 2.05 ± 0.64, ant-H:B, 1.97 ± 0.61, LAO-H:B, 2.06 ± 0.64, all p = ns). However, 3D-H:B was increased compared to planar H:Bs (3D-H:B, 4.06 ± 1.77, all p r = 0.45, p Conclusion 3D semi-quantitative analysis of CZT SPECT optimized the assessment of 99mTc-labeled bone tracer myocardial uptake in patients with cardiac amyloidosis.

Published
2019

7. Immune checkpoint inhibitor-induced hypophysitis

Author

David Dudoignon, Sarah Guégan, and Maxime Barat

Subjects
Pituitary gland, Radiological and Ultrasound Technology, medicine.diagnostic_test, Hypophysitis, business.industry, Melanoma, Immune checkpoint inhibitors, Ipilimumab, Magnetic resonance imaging, General Medicine, medicine.disease, medicine.anatomical_structure, medicine, Cancer research, Humans, Radiology, Nuclear Medicine and imaging, business, Immune Checkpoint Inhibitors, medicine.drug
Published
2021

8. Quantification of myocardial

Author

Alain, Manrique, David, Dudoignon, Stéphanie, Brun, Catherine, N'Ganoa, Emmanuelle, Cassol, Damien, Legallois, Yoan, Lavie-Badie, Denis, Agostini, and Olivier, Lairez

Subjects
Cardiac amyloidosis, CZT SPECT, Bone scintigraphy, Planar imaging, Original Research
Abstract

Purpose We aimed to compare different methods for semi-quantitative analysis of cardiac retention of bone tracers in patients with cardiac transthyretin amyloidosis (ATTR). Methods Data from 67 patients with ATTR who underwent both conventional whole-body scan and a CZT myocardial SPECT (DSPECT, Spectrum Dynamics) 3 h after injection of 99mTc-labeled bone tracer were analyzed. Visual scoring of cardiac retention was performed on whole-body scan according to Perugini 4-point grading system from 0 (no uptake) to 3 (strong cardiac uptake with mild/absent bone uptake). A planar heart-to-background (H:B) ratio was calculated using whole-body scan (wb-H:B). CZT SPECT was quantified using three methods: planar H:B ratio calculated from anterior reprojection (ant-H:B), left anterior oblique reprojection (LAO-H:B), and 3D-H:B ratio calculated from transaxial slices as mean counts in a VOI encompassing the heart divided by background VOI in the contralateral lung. Interventricular septal thickness was obtained using echocardiography. Results H:Bs obtained from planar and reprojected data were not statistically different (wb-H:B, 2.05 ± 0.64, ant-H:B, 1.97 ± 0.61, LAO-H:B, 2.06 ± 0.64, all p = ns). However, 3D-H:B was increased compared to planar H:Bs (3D-H:B, 4.06 ± 1.77, all p

Published
2019

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