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1,306 results on '"Davidoff, Andrew M."'

6. Genetic and epigenetic features of bilateral Wilms tumor predisposition in patients from the Children’s Oncology Group AREN18B5-Q

Author

Murphy, Andrew J., Cheng, Changde, Williams, Justin, Shaw, Timothy I., Pinto, Emilia M., Dieseldorff-Jones, Karissa, Brzezinski, Jack, Renfro, Lindsay A., Tornwall, Brett, Huff, Vicki, Hong, Andrew L., Mullen, Elizabeth A., Crompton, Brian, Dome, Jeffrey S., Fernandez, Conrad V., Geller, James I., Ehrlich, Peter F., Mulder, Heather, Oak, Ninad, Maciezsek, Jamie, Jablonowski, Carolyn M., Fleming, Andrew M., Pichavaram, Prahalathan, Morton, Christopher L., Easton, John, Nichols, Kim E., Clay, Michael R., Santiago, Teresa, Zhang, Jinghui, Yang, Jun, Zambetti, Gerard P., Wang, Zhaoming, Davidoff, Andrew M., and Chen, Xiang

Published
2023
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7. Genome-wide mapping of cancer dependency genes and genetic modifiers of chemotherapy in high-risk hepatoblastoma

Author

Fang, Jie, Singh, Shivendra, Cheng, Changde, Natarajan, Sivaraman, Sheppard, Heather, Abu-Zaid, Ahmed, Durbin, Adam D., Lee, Ha Won, Wu, Qiong, Steele, Jacob, Connelly, Jon P., Jin, Hongjian, Chen, Wenan, Fan, Yiping, Pruett-Miller, Shondra M., Rehg, Jerold E., Koo, Selene C., Santiago, Teresa, Emmons, Joseph, Cairo, Stefano, Wang, Ruoning, Glazer, Evan S., Murphy, Andrew J., Chen, Taosheng, Davidoff, Andrew M., Armengol, Carolina, Easton, John, Chen, Xiang, and Yang, Jun

Published
2023
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9. Histone lysine demethylase 4 family proteins maintain the transcriptional program and adrenergic cellular state of MYCN-amplified neuroblastoma

Author

Abu-Zaid, Ahmed, Fang, Jie, Jin, Hongjian, Singh, Shivendra, Pichavaram, Prahalathan, Wu, Qiong, Tillman, Heather, Janke, Laura, Rosikiewicz, Wojciech, Xu, Beisi, Van De Velde, Lee-Ann, Guo, Yian, Li, Yimei, Shendy, Noha A.M., Delahunty, Ian M., Rankovic, Zoran, Chen, Taosheng, Chen, Xiang, Freeman, Kevin W., Hatley, Mark E., Durbin, Adam D., Murray, Peter J., Murphy, Andrew J., Thomas, Paul G., Davidoff, Andrew M., and Yang, Jun

Published
2024
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17. Critical elements of pediatric neuroblastoma surgery

Author

Shaffiey, Shahab A., Le, Hau D., Christison-Lagay, Emily, Fialkowski, Elizabeth A., Aldrink, Jennifer H., Grant, Christa N., Honeyman, Joshua N., Janek, Kevin C., Madonna, Mary Beth, Rhee, Daniel S., Nuchtern, Jed G., Newman, Erika A., LaQuaglia, Michael P., Davidoff, Andrew M., Shamberger, Robert C., and Malek, Marcus M.

Published
2023
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21. A Phase II Trial of Hu14.18K322A in Combination with Induction Chemotherapy in Children with Newly Diagnosed High-Risk Neuroblastoma

Author

Furman, Wayne L, Federico, Sara M, McCarville, Mary Beth, Shulkin, Barry L, Davidoff, Andrew M, Krasin, Matthew J, Sahr, Natasha, Sykes, April, Wu, Jianrong, Brennan, Rachel C, Bishop, Michael William, Helmig, Sara, Stewart, Elizabeth, Navid, Fariba, Triplett, Brandon, Santana, Victor M, Bahrami, Armita, Anthony, Gwendolyn, Yu, Alice L, Hank, Jacquelyn, Gillies, Stephen D, Sondel, Paul M, Leung, Wing H, and Pappo, Alberto S

Subjects
Clinical Trials and Supportive Activities, Neuroblastoma, Rare Diseases, Cancer, Neurosciences, Pediatric, Pediatric Cancer, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Adolescent, Adult, Antibodies, Monoclonal, Humanized, Antineoplastic Combined Chemotherapy Protocols, Child, Disease-Free Survival, Female, Gangliosides, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Induction Chemotherapy, Kaplan-Meier Estimate, Killer Cells, Natural, Male, Progression-Free Survival, Prospective Studies, Young Adult, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

PurposeWe sought to evaluate whether combining a humanized antidisialoganglioside mAb (hu14.18K322A) with induction chemotherapy improves early responses and outcomes in children with newly diagnosed high-risk neuroblastoma.Patients and methodsWe conducted a prospective nonrandomized, single-arm, two-stage, phase II clinical trial. Six courses of induction chemotherapy were coadministered with hu14.18K322A and followed with granulocyte-macrophage colony-stimulating factor (GM-CSF) and low-dose IL2. Consolidation was performed with a busulfan/melphalan preparative regimen. An additional course of hu14.18K322A was administered with parent-derived natural killer cells, when available, during consolidation. Hu14.18K322A, GM-CSF, IL2, and isotretinoin were then administered. Secondary outcomes included reduced tumor volume and semiquantitative 123I-metaiodobenzylguanidine scoring [i.e., Curie scores (CS)] at the end of induction.ResultsForty-two patients received hu14.18K322A and induction chemotherapy. This regimen was well tolerated, with continuous-infusion narcotics adjusted to patient tolerance. Partial responses (PR) or better after the first two chemoimmunotherapy courses occurred in 32 patients [76.2%; 95% confidence interval (CI), 60.6-88.0]. This was accompanied by primary tumor volume reductions (median, -76%; range, -100% to 5%). Of 35 patients with stage IV disease who completed induction, 31 had end-of-induction CSs of 2 or less. No patients experienced progression during induction. Two-year event-free survival (EFS) was 85.7% (95% CI, 70.9-93.3).ConclusionsAdding hu14.18K322A to induction chemotherapy produced early PR or better in most patients, reduced tumor volumes, improved CSs at the end of induction, and yielded an encouraging 2-year EFS. These results, if validated in a larger study, may change the standard of care for children with high-risk neuroblastoma.

Published
2019

24. Data from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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25. Supplementary Data File 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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26. Supplementary Figure 15 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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27. Supplementary Table 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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28. Supplementary Data File 1 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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29. Supplementary Methods from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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30. Supplementary Figure 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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31. Supplementary Table 2 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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32. Supplementary Figure 9 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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33. Supplementary Data File 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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34. Supplementary Figure 6 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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35. Supplementary Figure 3 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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36. Supplementary Figure 4 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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37. Supplementary Figure 8 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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38. Supplementary Figure 5 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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39. Supplementary Figure 7 from Oncogenic Cells of Renal Embryonic Lineage Sensitive to the Small-Molecule Inhibitor QC6352 Display Depletion of KDM4 Levels and Disruption of Ribosome Biogenesis

Author

Pichavaram, Prahalathan, primary, Jablonowski, Carolyn M., primary, Fang, Jie, primary, Fleming, Andrew M., primary, Gil, Hyea Jin, primary, Boghossian, Andrew S., primary, Rees, Matthew G., primary, Ronan, Melissa M., primary, Roth, Jennifer A., primary, Morton, Christopher L., primary, Zambetti, Gerard P., primary, Davidoff, Andrew M., primary, Yang, Jun, primary, and Murphy, Andrew J., primary

Published
2024
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41. Role of the extent of prophylactic regional lymph node radiotherapy on survival in high‐risk neuroblastoma: A report from the COG A3973 study

Author

Braunstein, Steve E, London, Wendy B, Kreissman, Susan G, Villablanca, Judith G, Davidoff, Andrew M, DeSantes, Kenneth, Castleberry, Robert P, Murray, Kevin, Diller, Lisa, Matthay, Katherine, Cohn, Susan L, Shulkin, Barry, Allmen, Daniel, Parisi, Marguerite T, Ryn, Collin, Park, Julie R, Quaglia, Michael P, and Haas‐Kogan, Daphne A

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Oncology and Carcinogenesis, Pediatric Research Initiative, Patient Safety, Pediatric Cancer, Neurosciences, Neuroblastoma, Cancer, Rare Diseases, Transplantation, Pediatric, 6.5 Radiotherapy and other non-invasive therapies, 6.4 Surgery, Evaluation of treatments and therapeutic interventions, Disease-Free Survival, Female, Humans, Infant, Infant, Newborn, Lymph Nodes, Male, Survival Rate, high risk, lymph nodes, neuroblastoma, radiotherapy, Paediatrics and Reproductive Medicine, Oncology & Carcinogenesis, Oncology and carcinogenesis, Paediatrics
Abstract

PurposeNeuroblastoma is the most common extracranial solid pediatric malignancy, with poor outcomes in high-risk disease. Standard treatment approaches employ an increasing array of aggressive multimodal therapies, of which local control with surgery and radiotherapy remains a backbone; however, the benefit of broad regional nodal irradiation remains controversial. We analyzed centrally reviewed radiation therapy data from patients enrolled on COG A3973 to evaluate the impact of primary site irradiation and the extent of regional nodal coverage stratified by extent of surgical resection.MethodsThree hundred thirty high-risk neuroblastoma patients with centrally reviewed radiotherapy plans were analyzed. Outcome was evaluated by the extent of nodal irradiation. For the 171 patients who also underwent surgery (centrally reviewed), outcome was likewise analyzed according to the extent of resection. Overall survival (OS), event-free survival (EFS), and cumulative incidence of local progression (CILP) were examined by Kaplan-Meier, log-rank test (EFS, OS), and Grey test (CILP).ResultsThe five-year CILP, EFS, and OS for all 330 patients receiving radiotherapy on A3973 were 8.5% ± 1.5%, 47.2% ± 3.0%, and 59.7% ± 3.0%, respectively. There were no significant differences in outcomes based on the extent of lymph node irradiation regardless of the degree of surgical resection (

Published
2019

44. Why do subcutaneous ports get stuck? A case-control study

Author

Crook, Jennifer L., Lu, Zhaohua, Wang, Xiaoqing, Henderson, Nan, Proctor, Kimberly E., Maller, Vinod G., Prajapati, Hasmukh J., Gold, Robert E., Abdelhafeez, Abdelhafeez H., Talbot, Lindsay J., Pui, Ching-Hon, Davidoff, Andrew M., Hoffman, James M., and Murphy, Andrew J.

Published
2022
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45. Interhospital variability in localization techniques for small pulmonary nodules in children: A pediatric surgical oncology research collaborative study

Author

Morgan, Katrina M., Anderson, K. Tinsley, Johnston, Michael E., Dasgupta, Roshni, Crowley, John J., Fahy, Aodhnait S., Lapidus-Krol, Eveline, Baertschiger, Reto M., Lautz, Timothy B., Many, Benjamin T., Marquart, John P., Gainer, Haley, Lal, Dave R., Rich, Barrie S., Glick, Richard D., MacArthur, Taleen A., Polites, Stephanie F., Kastenberg, Zachary J., Short, Scott S., Meyers, Rebecka L., Talbot, Lindsay, Abdelhafeez, Abdelhafeez, Prajapati, Hasmukh, Davidoff, Andrew M., Rubaclava, Nathan, Newman, Erika, Ehrlich, Peter F., Rothstein, David H., Roach, Jonathan P., Ladd, Patricia, Janek, Kevin C., Le, Hau D., Leraas, Harold J., Tracy, Elisabeth T., Bisset, Logan, Mora, Maria C., Warren, Patrick, Aldrink, Jennifer H., and Malek, Marcus M.

Published
2022
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49. Author Correction: Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice

Author

Singh, Gurdeep, Stefanelli, Gilda, Narkaj, Klotilda, Brimble, Mark A., Creighton, Samantha D., McLean, Timothy A. B., Hall, Meaghan, Mitchnick, Krista A., Zakaria, Jacqueline, Phung, Thanh, Reda, Anas, Leonetti, Amanda M., Monks, Ashley, Ianov, Lara, Winters, Boyer D., Walters, Brandon J., Davidoff, Andrew M., Mitchell, Jennifer A., and Zovkic, Iva B.

Published
2022
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50. Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice

Author

Singh, Gurdeep, Stefanelli, Gilda, Narkaj, Klotilda, Brimble, Mark A., Creighton, Samantha D., McLean, Timothy A. B., Hall, Meaghan, Mitchnick, Krista A., Zakaria, Jacqueline, Phung, Thanh, Reda, Anas, Leonetti, Amanda M., Monks, Ashley, Ianov, Lara, Winters, Boyer D., Walters, Brandon J., Davidoff, Andrew M., Mitchell, Jennifer A., and Zovkic, Iva B.

Published
2022
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