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Introduction Hyperdontia or supernumerary teeth are excess number of teeth in comparison to normal dentition. The aim of this study was to present different variants of permanent supernumerary teeth, as well as their observation or elimination in order to prevent possible complications Case report Six different cases of hyperdontia are presented in this paper. All hyperdontia cases were multidisciplinary evaluated and individual treatment protocols were applied. Already erupted supernumerary teeth were extracted without surgical intervention. Unerupted teeth were surgically removed or left for observation. Conclusion Early and frequent dental check-ups are very important for children in order to detect possible dentition irregularities and thus timely start with appropriate therapy

Background/Aim. Asthma is a chronic inflammatory lung disorder. The effect of asthma drugs on oral health is still the subject of debate among researchers in dentistry. The aim of this study was t o e valuate dental status in asthmatic children and evaluate the possible effect of drugs treating asthma on dental health. Methods. Study participants were divided into two groups: the asthma (AG) and the non-asthma (NAG) group. Based on the symptoms of asthma and the possibility for effective control of the disease, the AG group was divided into two subgroups. The oral examination of the teeth was per-formed using a probe and mouth mirror under artificial light in accordance with the recommendations of the World Health Organization. Saliva analysis was carried out by the GC Saliva-Check Buffer, according to the manufacturer's instructions. Results. The study included 136 children aged 6 to 16 years (10.5 ± 3.3). The mean of decayed, missing, and filled teeth (dmft/DMFT) of the children in the AG group (6.0 ± 4.0/3.3 ± 4.4) was higher than in the NAG group (4.8 ± 4.4/2.5 ± 3.4), but significant differences were not observed between the groups. Salivary pH values were found to be similar in both groups, but the quantity and buffering capacity of the stimulated saliva were found to be significantly lower in the AG group (p < 0.001 and p < 0.05, respectively). Conclusion. Although the prevalence of dental caries in the AG group was similar to that of the NAG group in this study, decreased quantity and buffering capacity of the stimulated saliva in the A G group may contribute to higher values of dental caries in asthmatic children in the future.

Introduction/Objective. University teachers have a challenging task in finding creative ways to present educational content. One of them is to create applications dedicated to educational purposes, which students can use on their mobile phones any time. The aim of this study was to evaluate the impact of mobile learning of dentistry students during COVID- 19 pandemic. Methods. The prospective study involved 56 students from two medical faculties in the Balkans, who continued to study online after the declaration of the COVID-19 pandemic. Online teaching was based on material in the form of PowerPoint presentations. In order to provide an additional educational tool, a step-by-step mobile application for managing traumatic dental injuries was developed. After one week of using that mobile application, all students completed a questionnaire in electronic form concerning teaching satisfaction. Results. Over 90% of the respondents stated that the application facilitated a learning process, improved their understanding of the teaching unit, and provided a great convenience in terms of access to information. Median value of the total score concerning clinical protocol by the use of application was 20 (16–20), which was significantly higher than the neutral value (p < 0.001). Median value of the total score concerning the use of conventional PowerPoint presentations did not differ significantly from the neutral value (p = 0.284). Conclusion. Mobile learning resulted in improved knowledge of dental traumatology diagnostics and treatment among undergraduate dentistry students during COVID-19 pandemic.

Introduction Oral diseases during pregnancy are an important reason for enhanced dental care of this vulnerable population. The aim of this study was to determine the degree of oral health awareness among pregnant women and examine their oral hygiene habits, attitudes and behaviors in relation to the professional qualification. Material and methods The study was conducted in Foča, East Sarajevo, Bijeljina and Pale (Republika Srpska, Bosnia and Herzegovina). A total of 198 respondents voluntarily filled an anonymous survey, specially created for this research. Results In addition to toothbrush and toothpaste, 39.8% of pregnant women did not use any additional oral hygiene resources. When brushing their teeth, 60.1% of pregnant women had bleeding gums. Also, 54.1% of pregnant women visited dentist, while 34.3% did not. Obstetrician did not advise 69.7% of respondents that the should visit dentist during pregnancy. Furthermore, 80.8% of pregnant women thought that they were more susceptible to pregnancy caries, and 29.6% of them thought that caries is disease that cannot be prevented. Respondents with university education understood that minerals from the mother's teeth were not lost during pregnancy, which was statistically significant compared to pregnant women with secondary education. Conclusion The level of oral health awareness of pregnant women is low. It is important that all women perform regular dental examination during pregnancy, as they will receive useful information from their dentist how to prevent oral diseases.

Technological solutions and environmental conditions have a significant impact on infestation intensity and the problems around D. gallinae control. Changes in keeping laying hens in EU, in terms of D. gallinae influence, have not led to the welfare of the layers. On the contrary, they have contributed to the spreading of disease, have worsened conditions for control and accentuated harmful consequences. Apart from the poultry, these changes have also had a negative impact on the welfare of humans, through a toxicological and zootonic risk, and economic damages. Conventional cages so far provide the most appropriate environment for D. gallinae control. Opportunities for improving, even solving the problem of D. gallinae control in egg production do exist, however they require a changing the entire approach hitherto.

Introduction Maxillary labial frenulum (MLF) is a mucous membrane fold that shows diversity in morphology, position and clinical significance throughout life. The aim of the study was to evaluate different morphological variations and MLF attachment site prevalence in elementary school children. Material and methods the study included 110 children of "Ljutica Bogdan" Primary School in Kalinovik, Bosnia and Herzegovina. Clinical examinations were performed visually under natural light. The upper lip was lightly elevated with the forefingers and thumbs of both hands in horizontal alignment from alveolar ridge. Morphological variations were registered in accordance with Sewerin classification and attachment site according to Plaček et al. Results the study included 49 (44.6%) male and 61 (55.4%) female subjects. Mucosal MLF was registered in 57.3%, gingival in 17.3%, papillary in 20.9% and papilla penetrating in 4.5% of examined children. Frenulum simplex was registered in 64.6%, persistent tectolabial frenulum in 4.5%, frenulum with appendix in 9.1%, frenulum with nodule in 14.5%, duplication of frenulum in 5.5%, frenulum with two or more variations was registered in 1.8% of respondents. No difference was observed in morphological variations and attachment site positions between genders. Conclusion Most prevalent MLF morphological type was frenulum simplex and mucosal attachment site. Familiarity with MLF morphology, attachment site position as well as prevalence of different variations is very important in everyday clinical practice from the aspect of proper oral hygiene maintenance, periodontal disease prevention, orthodontic treatment and proper surgical therapy.

The development and implementation of the computer methods at project managing in the part of the planning of designing and installation of mechanical elements with the fit (assembly block) of the gear speed reducer is significant and at present irreplaceable engineering task if it has been realized by the modern parameter technology. There are multifunction uses of this organized group of activities, beginning from the quick changeability of elements still in the phase of designing and constructing, thanks to the characteristics of their associativity, still to the wide basis of standard elements that are incorporated in the very program package. Meanwhile, these activities are not simple, so their realization has to be planned from the stand - point of time, resource and cost of realization. For the very designing and constructing was used AutoCAD Mechanical, and for the design managing Microsoft Project. [ABSTRACT FROM AUTHOR]

Designing of the high - performance algorithms by the computer methods at the establishing of the states of stress of the brake mechanisms by the methods of the final elements is very substantial with fast and precise analysis of the state of stress and rigidity of the machine parts and the fits of machine parts affter forming its virtual, and later as well as real geometry. There are multiple reasons for it, and they include: economy, interchangeability and primarily its operating certainty, whose function is unavoidable especially with the parts as the brake mechanisms. To that effect are the results in the designing obtained by final elements analysis (FEA) or similar methods, very useful. [ABSTRACT FROM AUTHOR]

This is a very substantial activity in which designer finds out possible deformations, rigidities (stifnesses) and stress states of the machine parts and fits after forming its virtual geometry, and later the real one as well. They are of the essential importance at the fast and accurate analysis of the possible elastic and plastic body deformation. In this case the point is the solid object of the device beam of an -- agro -- machine of relatvivelly more complex configuration. [ABSTRACT FROM AUTHOR]

Introduction Tooth and other oral tissue damage can occur at any time of life. Traumatic extraction is a complex traumatic injury characterized by complete dislodgement of the tooth from its alveolus. The diagnosis of traumatically injured teeth includes X-rays and a detailed clinical examination. Case report A twelve-year-old boy reported at the dental clinic of the Faculty of Medicine due to the injury in the anterior maxillary region. It was a sport injury. The time elapsed since the accident was 2 hours and 20 minutes. According to the clinical examination and X-rays the diagnosis was: The teeth 11 and 21 - Complete traumatic dental avulsion and fracture; 22- Hypodontia and chin contusion and laceration. The teeth were brought in physiological solution. After applying local anesthetic, soft tissue was cleaned, the teeth positioned back in their alveoli and an immobilizing splint of fiberglass fibers placed. The patient was administered antibiotics and recommended tetanus prophylaxis. Seven days after the injury, teeth were treated endodontically. After one month, the immobilizing splint was removed. The tooth 21 was definitely obturated and composite buildups were done on both teeth. Calcium hydroxide dressing was left in the canal of the tooth 11. One month and 3 weeks after the injury, a fistula appeared above the tooth 11, and the treatment was finally completed after seven months. Conclusion Traumatic tooth injuries, of any kind, require urgent treatment as time loss usually reduces chances for successful treatment. One year after the injury, the patient had no symptoms and the result was functional and aesthetically acceptable.

Background/Aim. Oral health is an important part of overall health. Good oral health is important for oral diseases prevention and health maintenance of respiratory system. The aim of the study was to evaluate oral hygiene and periodontal health parameters of asthmatic children and to compare them with children without asthma as well as to evaluate those parameters according to type of used medications and time of taking medications in children with asthma. Methods. This epidemiological study included 68 children with asthma and 68 children without asthma or any other chronic disease aged from 6 to 16 years. Parameters used in this study were Greene-Vermillion index, Löe-Silness gingival index and Community Periodontal Index (CPI). Results. Good oral hygiene (31.1%) was more present in children without asthma whereas poor hygiene (20.0%) was more frequent in children with asthma (p < 0.001). Healthy gingiva was more frequent in children without asthma (25%) while mild (58.8%) and moderate gingival inflammation (5.9%) were more frequent in the group of children with asthma (p < 0.01). Mean CPI values were higher in children with asthma (p < 0.001). Mean values of Plaque Index, Gingival Index and CPI did not show statistically significant difference in relation to type of administered medication. However, taking medications in the afternoon was related to higher mean values of Plaque Index and Gingival Index (p < 0.05) within the group of children with asthma. Conclusion. Children with asthma had poorer oral hygiene and were diagnosed with greater values of oral hygiene and periodontal indices compared with the group of children without asthma. For this reason, it is necessary to promote oral health and establish good oral hygiene habits in asthmatic children.

Backgraund/Aim. Increased body weight in childhood may have negative effects on many tissues and organs in the body. The aim of this study was to determine whether the state of oral health in children with increased body mass is different from the children with normal body weight. Methods. The study included 190 children, aged 6 to 15 years. Assessment of nutritional status of subjects was performed by the use of Body Mass, and the respondents were divided into a group of increased body weight children (IWC) and a group of normal body weight children (NWC). Hard dental tissue state of health was assessed by the decayed, missing and filled teeth (DMFT) index. The gingival health was assessed using gingival index (GI). Community Periodontal Index (CPI) was used for the assessment of periodontal tissue. The oral hygiene was assessed using the Simplified Debris (Plaque) Index Greene-Vermilion. Results. Average DMFT value in the IWC group was 5.01 ± 2.4, and in the NWC 4.43 ± 2.0; (p > 0.05). GI values in the IWC group was 0.64 ± 0.37, while in the NWC group it was 0.55 ± 0.35 (the difference was not statistically significant). Average CPI index values were 1.33 ± 0.49 in the IWC group and 0.77 ± 0.61 in the NWC group and statistically significant differences were observed concerning periodontal tissue state of health. The GV index values in the IWC group were 1.01 ± 0.49, and in the NWC group 0.89 ± 0.45; it was not statistically significant. Conclusion. Results of this research do not indicate that children with increased body weight have more affected teeth. However, they have a worse condition of periodontal tissue in comparison to normal weight children.

Introduction The aim of this research was to determine oral hygiene related habits, knowledge and behavior in children with asthma compared to healthy children. Methodology This study included 136 children, between 6 to 16 years of age, divided into the two groups. The first group included children with asthma (study group - SG), while the second included healthy children (control group - CG). A questionnaire containing three groups of questions related to oral-hygiene and dietery habits as well as oral health related behaviour in children was prepared. Results The percentage of children from SG that brush teeth several times a day was 60.2% compared to 77.2% of CG children (p0.05). More than half (52.9%) of CG respondents regularly visit dentist, while 50.0% of SG goes regularly (p

Introduction Fear of dental procedures is one of the main reasons for oral health neglect. The first permanent molars are functionally very important. Dental anxiety may compromise their health as well as the health of all other teeth. The aim of the study was to determine dental anxiety level and the status of first permanent molars in healthy school aged children. Methods This study included 105 students, 11 and 15 years of age, from two elementary schools in Foca (Bosnia and Herzegovina). Dental Anxiety Scale (DAS), questionnaire was used to determine the level of dental fear in patients. The status of first permanent molars was recorded using Klein-Palmer DMFT (decayed, missing, filling teeth) system. The number of healthy first permanent molars (with or without sealant) was registered as well. Results More than one third of respondents involved in this study (33.3%), suffered from severe dental anxiety (DAS = 13–20 points). Statistically significant difference in answers to questions was not observed between respondents of different age but higher level of the fear was registered in girls compared to boys (p < 0.05). Less than 50% of all examined first permanent molars were healthy and sealed fissures were recorded in 9.4% of them. The percentage of decayed molars was about 11%, 7% extracted and 35% filled. Conclusion Application of prophylactic measures is beneficial for dental health preservation. They are pain free and can be used to minimize fear by establishing dentist-patient relationship based on confidence.

Peripheral giant cell granuloma (PGCG) or 'epulis gigantocelularis' is the most common oral lesion that originates from giant cells. It typically manifests in the form of soft tissue tumor purple-red or red-watery color consisting of multinuclear giant cells in the mononuclear stroma and extravascular erythrocytes. This lesion is not considered true neoplasm, rather reactive lesion stimulated by local irritation and trauma. However, the cause is not known with certainty. This paper presents a 13-year-old boy with a large lesion in the region of right maxillary canine that was retained in jaw despite favorable vertical position and available space to accommodate in the dental arch. The lesion was completely removed under local anesthesia and histopathological findings confirmed the diagnosis of PGCG. Postoperative period went without complications. After four months additional surgical procedure was needed due to the recurrence, which after tooth naturally erupted and positioned in the dental arch.

Introduction Malocclusion is common in children and it has great influence on the quality of life of patients. The aim of this study was to determine the prevalence of malocclusion among 11-13 years old children in the municipality of Foca in Republika Srpska. Material and Methods The study included 81 respondents, 11-13 years old. It was conducted in elementary schools in the municipality of Foča. Respondents underwent clinical examination, alginate impressions of upper and lower jaws were taken and study models analyzed. To determine malocclusion (crowding, spacing, cross bite, deep bite, open bite and occlusion class as per Angle) ICON index (Index of Complexity, Outcome and Need) was used. Results The results showed that 17.3% of respondents had spacing between teeth, 80.2% crowding, 23.4% cross bite, 29.6% deep bite while open bite was present in 2.4% of patients. Occlusion II/1 class by Angle was present in 38.3% of respondents, II/2 class in 12.3% of respondents, Class I occlusion in 40.7% of respondents and III class was found in 2.4% of respondents. Conclusion There was high prevalence of malocclusion in the examined children. It is necessary to implement prevention programs, early treatment of dental caries, prevent premature tooth loss as well as measures of interceptive orthodontics in order to reduce frequency of malocclusion.

Introduction Self- assessment of oral health is simple, non-invasive and cost-effective method of collecting data that takes into account psychosocial aspects of oral health. The aim of this study was to investigate the effect of clinical factors on the self-perception of oral health in middle-aged patients in Republika Srpska (Bosnia and Herzegovina). Material and Methods The study included 126 subjects of both genders (34.1% male and 65.9% female) aged 24-54 years. Data were collected through questionnaires and clinical examination. Anonymous questionnaire contained questions related to socio-demographic characteristics of respondents. Clinical examination included teeth condition and the presence of prosthetic restorations. Self-perception of oral health was determined by one question. Results Bivariate analysis indicated significant effect of carious (p

Introduction. Caries and periodontal disease are the most common diseases afflicting oral tissues. Insufficient knowledge of the causes of these diseases leads to inappropriate behavior of patients towards their own oral health. The aim of this study was to determine the level of oral hygiene and its effect on the prevalence of dental caries in schoolchildren in Foča. Material and Methods. The study included 239 schoolchildren, 12 years old of both genders, attending four elementary schools in Foča. To assess their oral health methodology and criteria of the World Health Organization were used. Carious teeth were recorded and oral hygiene evaluated in accordance with Oral Hygiene Index. A questionnaire was used to obtain information about oral hygiene habits, reasons for dental visits as well as the number of dental visits. Results. The average number of affected teeth in the analyzed population was 5.43 and the average value of Oral Hygiene Index was 0.93. Good oral hygiene was noticed in 75% of respondents. Most respondents had at least one dental visit. Toothache was the most common reason for dental visit while the distance from clinics and fear of intervention were the most common reasons for not visiting dentist. Conclusion. In this part of Podrinje children had an average of more than five carious permanent teeth. Examined children from rural areas had poorer oral health, as well as lower number of visits to the health facilities compared to their peers in urban areas. Given that the most of examined children (75%) had good oral hygiene, other factors that led to significant number of carious teeth must be determined.

Background/Aim. Health education plays a very important role in maintaining health of individuals. Good oral health, as a part of general health, is largely dependent on the level of knowledge, attitudes and habits that children already have. The aim of this study is to examine the level of knowledge and habits in children regarding oral hygiene, diet and bad habits. Methods. The study included 506 school children aged 12 and 15 years in three towns (Foča, Čajniče, Kalinovik, Bosnia and Herzegovina). The survey was conducted in order to assess knowledge, attitudes and habits that children have in relation to their own oral health. Results. Most respondents stated that they began to brush their teeth at the age of 4, while a smaller number linked beginning of tooth brushing to the start of school. The parents more often help the boys during tooth brushing. A total of 54.9% of children brush their teeth after every meal, while 40.1% of them brush teeth only once during the day. Twelve year olds brush their teeth more often, especially after a meal. A total of 92.5% of children had never used fluoride tablets nor are the tablets recommended to them by anyone. More than half of the children (61.7%) visited the dentist for the first time before starting school that is on the regular examination that is performed upon enrollment to school. A pain as a reason for dental visits was present in 43.9%, while the preventive check in only 31.4% of the children. Conclusion. Children included in this study, particularly 15-year-olds, are quite well informed about teeth brushing frequency and proper selection of tools for hygiene maintenance, but this knowledge is not applied. Girls are more responsible for their own health, and come regularly to the preventive dental checkups.

Background/Aim. Developmental disorders of teeth are the problems that are becoming more present in pediatric dentistry, especially on first permanent molars and incisors. Molar Incisor Hypomineralization (MIH) is proposed term for this phenomenon. The aim of this study was to establish the MIH prevalence in children living in the Foča municipality (Bosnia and Herzegovina) as well as to assess characteristics and expression of hypomineralization within the tested population. Methods. A total of 141 children from the Foča municipality, 8 years of age, were included in this study. Criteria according to Weerhejm have been used for diagnosis of hypomineralization: demarcated opacity (DO), post-eruptive breakdown (PEB), atypical restoration (AR), extracted molars due to MIH (E-MIH) and unerupted tooth (UT). Level and the prominence of color changes have been determined for patients with DO, PEB and AR. Results. MIH in this area was present in 12.8% of children. The prevalence of MIH changes expressed in percentages was as follows: DO was at 9.2%, PEB in 3.5%, AR in 5.6%, while E-MIH was 5.6%. A total of 9.9% of the examinees had mild, 5.6% moderate, and 7.8% severe form of MIH. White form of MIH defects was found in 9.9% of the examinees, white-yellow one in 5.6% and yellow-brown color in 3.5% of the examined children. These changes were more often present in the lower jaw (60.3%). In total, 6.4% of children had these changes present only on molars, while 6.4% of them both on molars and incisors simultaneously. Conclusion. A total of 12.8% of the examinees with MIH is not to be disregarded. With timely diagnosis, prevention and therapy complications could be avoided or mitigated.

Introduction. Teeth hypomineralization that involves molars only, or molars and incisors is known as disease Molar Incisor Hypomineralization (MIH). Aetiology of MIH is not known, however, factors responsible for this disease are present in the first year of life. The aim of this research was to identify possible aetiological factors responsible for the occurrence of this disease. Material and Methods. The study included eight years old children from the municipality of Foca. Parents who gave their consent for the participation of children in the study completed a questionnaire in which they listed aetiological factors described in the literature to be responsible for the emergence of hypomineralization. Modified DDE index (Modified DDE Index for Use in Epidemiological Surveys) was used to estimate hypomineralization on all teeth; however, MIH changes were classified separately. Results. More than ninety different factors may be responsible for enamel defects. Possible aetiological factors listed in the literature are: premature birth, low weight of newborns, hypoxia, metabolic disorder of calcium and phosphate, fever, genetic factors, etc. Results did not confirm statistical significance for any of examined aetiological factors. Conclusion. In this study a retrospective analysis of data was performed. Etiological factors of MIH were identified but the most responsible for MIH were not determined.

Introduction. The problem of chronic diseases such as caries is very complex because it appears very early in life, often during childhood. The number of involved people is growing as well as the number of affected teeth and surfaces that eventually lead to teeth loss. The aim of this study was to determine the dental status of adolescents age 12 and 15 in three municipalities in Bosnia, Foca, Cajnice and Kalinovik. Material and methods. The study included 506 school children both genders of six schools in three municipalities (Foca, Cajnice and Kalinovik). Teeth examination and criteria for diagnosis and coding were estimated based of criteria of the European Academy of Paediatric Dentistry (EAPD). To estimate dental health DMFT index [number of carious teeth (D), missing (M) and filled teeth (F)] and related indices (Person Caries Index, Teeth Caries Index, Average Caries Index and DMFT structure) were used. Results. Dental health status and caries prevalence were presented through the values of the Average Caries Index. The value of Average Caries Index for examined children was 6.17. Of all examined children 96.05% of them had at least one carious tooth. The average value of Teeth Caries Index was 23.04%. Conclusion. Dental health of the children in the examined region was characterized by high values of untreated carious teeth as well as the other components of DMFT index. Therefore, preventive measures and primary dental care must be implemented better among school children.

Introduction. Oral health is an important part of general health. Knowledge, beliefs and attitudes that students acquire during dental school can influence their behavior towards not just their own health, but also towards health in their immediate environment. The aim of the study was to assess the level of oral health among dental students of the second and fifth year at the University of East Sarajevo. Material and Methods. Sixty-six students from the Dental Department of the Faculty of Medicine, the University of East Sarajevo were assessed. The study was conducted in 2012. The parameters used to assess oral health were: DMFT (decayed, missing, filled teeth) index and its components, index for the assessment of periodontal tissues (CPITN), and Green’s Vermillion oral hygiene debris index (DI). According to the methodology and criteria of the World Health Organization (WHO) all patients were examined using standard dental diagnostic tools under artificial light on dental chair. Results. Average number of decayed teeth of the second year students was 9.93 while it was 11.44 in the fifth year students. The mean dental caries index was 38.23% and person caries index was 100%. The average value of the debris index was 0.42. Healthy periodontium had 18.2% of students, while in 34.8% of students shallow periodontal pockets were observed. Conclusion. Oral hygiene and periodontal health was satisfactory in dental students. However, high average values of decayed teeth indicated that for better results caries preventive services should be activated earlier, even in school or preschool period.

Introduction. Periodontal diseases and primarily gingivitis occur relatively early in the childhood. It was found that 8.8% of children 3-6 years old had gingivitis and that number increased with age. Gingivitis is especially common during puberty and mixed dentition. The aim was to determine the prevalence and characteristics of gingival and periodontal diseases in children age twelve and fifteen in Republika Srpska. Material and Methods. The study included 506 students of both genders from six schools on the territory of the municipalities Foca, Cajnice and Kalinovik. For the evaluation of oral hygiene and periodontal status, indices suitable for research in pediatric population were used: Greene-Vermillion Debris Index (DI), Greene’s Calculus Index (CI), Oral Hygiene Index (OHI) and Community Periodontal Index of Treatment Needs (CPITN). The evaluation was carried out in accordance with the criteria for the diagnosis and non- communicable diseases, established in 1997 in Geneva. Results. The average DI value for all children was 0.86, the average CI 0.13, and OHI was 0.99. Healthy periodontium had 14.6% of respondents, while deep periodontal pockets of 4-5mm were found in 8.7% of fifteen-year-old children. Conclusion. A significant prevalence of gingivitis was found among examined children. It is necessary to highlight the importance of primary prevention measures, health education, proper training and regular oral hygiene, as well as regular check-ups in order to achieve better periodontal health in children.

Introduction. The emergence of deciduous teeth in the mouth of a child usually brings a joy to every parent. However, after ”short-time euphoria” deciduous teeth, in most cases, become the cause of pain, swelling, infection and further complications. The aim of this study was to assess the status of deciduous teeth in school children. Material and Methods. The study included children age 6-10 years from four cities in Republika Srpska. All respondents were divided in two groups: Group I included those who voluntarily came to be examined at the dental clinic and the Group II-those who were randomly chosen in schools. The examination was performed using dental mirror and probe. Caries verification was carried out by Klein-Palmer system, dmft (d - decay; m - missing; f - filling), and its related indices: Person caries index (pci) and Average caries index (aci). In addition, a survey was conducted. Results. A total number of 228 respondents were examined. Total pci was 96.1%. On average, each child had aci= 4.17 while 10.52% of the children had fillings in primary teeth. None of the children had sealed fissures on deciduous teeth. Physical examination revealed that 12.2% of the children had submucous abscess in oral cavity. The survey revealed that 3% of children did not have a tooth brush. Conclusion. The prevalence of caries in primary teeth is high, despite the fact that the Health Insurance Fund in Republika Srpska covers full cost for complete restoration of teeth in children up to 15 years old. Responsibility for the low percentage of healthy and filled teeth is relying mostly on parents as well as the entire community that should provide development and availability of public health dental care in all areas.

The activities of the enzymes dominantly localized within the proximal tubules, such as alanine aminopeptidase (AAP), gamma-glutamyl transferase (GGT) and N-acetyl-beta-D-glucosaminidase (NAG), were measured in 12-h urine samples of patients suffering from Gram-negative infections and i.v. treated with gentamicin with the aim of determining the nephrotoxicity of this aminoglycoside antibiotic. The examined groups consisted of 3-10 years old children of both sexes, gentamicin-treated, and the control group, each including 30 patients. Urine samples were collected and analyzed five days before the gentamicin application and during the following 10 days of gentamicin treatment (a single i.v. injection per day in the dose of 2.5 mg/kg b.w). Significant differences in the AAP and GGT activities expressed in U/mmol creatinine were observed between the gentamicin-treated group and the controls already on day 2 (p < 0.05) of the treatment, as well as in the activity of NAG on day 8 (p < 0.01) of the therapy. From these results it can be concluded that even standard gentamicin doses expressed nephrotoxic effects. Statistically significantly increased AAP and GGT activities in the gentamicin-treated group of children recorded already on the 2nd day of treatment demonstrate that these two enzymes represent extremely sensitive indicators of nephrotoxicity. On the other hand, statistically significantly increased NAG activity observed in the gentamicin-receiving group points to more severe gentamicin-provoked injuries of proximal tubules.

We present the results of theoretical researches of the developed hyperspherical function for the appropriate functional matrix, generalized on the basis of two degrees of freedom, and , and the radius . The precise analysis of the hyperspherical matrix for the field of natural numbers, more specifically the degrees of freedom, leads to forming special translators that connect functions of some hyperspherical and spherical entities, such as point, diameter, circle, cycle, sphere, and solid sphere

Aim: This prospective cohort study was undertaken to evaluate the success rate of root canal treatment (RCT) in type 2 diabetes mellitus (T2DM) patients with targeted level and unachieved targeted level of glycaemic control as well as the impact of RCT on the glucose blood level in T2DM patients., Methodology: Patients needing RCT were divided into three groups: these without T2DM, that is, the control group (CG), those with targeted level of glycated haemoglobin HbA1c < 7% (TL A1c) and the third ones with unachieved targeted level (UTL A1c), that is, with HbA1c ≥ 7%. Before RCT, HbA1c and the periapical index (PAI) score were assessed, as well as 1 year later., Results: Our results showed less favourable treatment results of RCT such as a reduction of radiographic lesions in T2DM patients, particularly in subjects with UTL A1c. The intergroup analysis of PAI score at the 12-month follow-up revealed a significant difference in TL A1C (p = .022) and CG (p = .001) with respect to UTL A1c. Total number of healed teeth (PAI≤2) at the 12-month after RCT in UTL A1c was significantly lower in comparison to CG (p = .008). Contrariwise, RCT may improve the glycaemic control in diabetic patients with UTL A1c after 12 months of posttreatment. Regression analysis showed that UTL A1c patients were more likely to have AP persistence after endodontic treatment (OR = 4.788; CI: 1.157-19.816; p = .031)., Conclusions: T2DM retards the AP healing and conversely AP contributes to increasing the inflammatory burden in T2DM. RCT reduces the cumulative inflammatory burden in T2DM and thus may contribute to improvement of glycaemic control particularly in patients with UTL A1c., (© 2024 British Endodontic Society. Published by John Wiley & Sons Ltd.)

(1) Background: To assess the relationship between serum interleukin-6 (IL-6), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) values and disease severity in patients with chronic spontaneous urticaria (CSU) and to examine which of these serum biomarkers better indicates disease severity. (2) Methods: Our pilot study included 20 patients with CSU who filled out questionnaires concerning disease severity and quality of life (the Urticaria Activity Score summed over 7 days [UAS7], the once-daily Urticaria Activity Score [UAS], the Urticaria Control Test [UCT], and the Dermatology Life Quality Index [DLQI]). Blood samples were taken to measure IL-6, ESR and CRP. (3) Results: ESR significantly correlated with the UAS7 (linear and moderate correlation; r = 0.496; p = 0.026), while CRP did not correlate with disease severity. IL-6 correlated with the once-daily UAS (r = 0.472; p = 0.036) and DLQI (r = 0.504; p = 0.023) (linear and moderate correlation) but not the UAS7 or UCT. (4) Conclusions: IL-6 was a better indicator of the once-daily UAS and DLQI, while ESR was a better indicator of the UAS7 (there was no correlation between IL-6, CRP and ESR parameters). Although our results are promising, this study should be conducted with a larger number of CSU patients.

Background: The clinical measures are not sufficient to assess oral health because they don't tell us anything about functional and psychosocial aspects of oral health and do not reflect person's concerns and subjectively perceived symptoms. This study aimed to investigate the validity, reliability and responsiveness of the child Oral Impacts on Daily Performances (C-OIDP) index among Bosnian 12-14 years old schoolchildren., Methods: The study population comprised 203 primary schoolchildren aged 12-14 years attending three schools in the eastern part of Bosnia and Herzegovina. Data were collected through: a clinical oral examination, oral health questionnaire and C-OIDP questionnaire. The validity and reliability of the C-OIDP were tested on a sample of 203 school-going children while responsiveness of the C-OIDP was assessed on 42 randomly chosen participants requiring a dental treatment., Results: In terms of reliability, Cronbach's alpha coefficient and the intraclass correlation coefficient were 0.86 and 0.85, respectively. Regarding the testing of construct validity, the C-OIDP score was increased as children's self-reported oral health changed from excellent to very bad and from very satisfied to dissatisfied. There was a significant improvement in C-OIDP post-treatment score compared with C-OIDP pre-treatment score. Overall, 63.4% of participants reported at least one oral impact in the last 3 months. The most affected performances were "eating" (38.4%) and "speaking" (25.1%)., Conclusion: The Bosnian version of the C-OIDP showed satisfactory validity, reliability and responsiveness and can be used as an appropriate OHRQoL measure for further epidemiological researches., (© 2023. The Author(s).)

Background: Chromogranin A (CgA) is a valuable biomarker for detection and follow-up of patients with neuroendocrine neoplasms (NENs). However, various comorbidities may influence serum CgA, which decreases its diagnostic accuracy. We aimed to investigate which laboratory parameters are independently associated with increased CgA in real-life setting and to develop a scoring system, which could improve the diagnostic accuracy of CgA in detecting patients with NENs., Methods: This retrospective study included 55 treatment naïve patients with NENs and160 patients with various comorbidities but without NEN (nonNENs). Scoring system (CgA-score) was developed based on z-scores obtained from receiver operating curve analysis for each parameter that was associated with elevated serum CgA in nonNENs., Results: CgA correlated positively with serum BUN, creatinine, α2-globulin, red-cell distribution width, erythrocyte sedimentation rate, plasma glucose and correlated inversely with hemoglobin, thrombocytes and serum albumin. Serum CgA was also associated with the presence of chronic renal failure, arterial hypertension and diabetes and the use of PPI. In the entire study population, CgA showed an area under the curve of 0.656. Aforementioned parameters were used to develop a CgA-score. In a cohort of patients with CgA-score <12.0 (N = 87), serum CgA >156.5 ng/ml had 77.8% sensitivity and 91.5% specificity for detecting NENs (AUC 0.841, 95% CI 0.713-0.969, P < 0.001). Serum CgA had no diagnostic value in detecting NENs in patients with CgA-score >12.0 (AUC 0.554, 95% CI 0.405-0.702, P = 0.430)., Conclusions: CgA-score encompasses a wide range of comorbidities and represents a promising tool that could improve diagnostic performance of CgA in everyday clinical practice.

Background: Serum chromogranin A (CgA) is routinely used as a biomarker in patients with neuroendocrine neoplasms (NENs). Several conditions and comorbidities may be associated with falsely elevated CgA, often leading to extensive diagnostic evaluation, which may be costly and harmful. The aim of this study was to analyze the effectiveness of the acute octreotide suppression test (AOST) in differentiating falsely elevated serum CgA., Methods: Our prospective study enrolled 45 patients from two different patient cohorts: (1) 29 patients with suspicion or presence of NENs (extensive workup and subsequent biopsy confirmed 16 NENs); (2) 16 consecutive patients admitted via the Emergency Department without NENs (non-NENs). AOST was performed after an overnight fast. Baseline CgA was measured, after which 0.25 mg of octreotide was administered subcutaneously. CgA was measured 3 and 6 h after administration., Results: Baseline CgA levels were similar in NENs and non-NENs. At the end of the AOST, CgA decreased by a median of 83.3% (41.0-127.4) in non-NENs and 13.8% (0.0-43.6) in NENs (p < 0.001). In patients with increased baseline CgA, a decrease in CgA at the 6th hour of < 51.3% had 90.0% sensitivity and 88.9% specificity in detecting NENs. In patients with normal baseline serum CgA, a decrease in CgA at the 3rd hour of < 17.6% had 83.3% sensitivity and 81.8% specificity in detecting patients with NENs. The diagnostic accuracy of the AOST in the entire study population was 86.7%., Conclusions: AOST is a promising tool to increase the diagnostic accuracy of serum CgA., (©2018 S. Karger AG, Basel.)

Objectives: Peroxynitrite is species claimed to propagate ischemia/reperfusion damage. In this report levels of serum uric acid (UA), a peroxynitrite scavenger, are compared with creatine phosphokinase (CPK) in male patients before and after open-heart surgery in order to asses if increased levels of UA may protect heart from biochemical damage induced by peroxynitrite during the coronary by-pass grafting (CABG) intervention., Methods: 45 male patients (16 carvedilol pretreated (6.25 mg/ daily, during 6 weeks before surgery, mean age 55.3+/-1.7 years, range 50-71) and 29 patients without carvedilol pretreatment (mean age 58.3+/-1.4 years, range 47-73) underwent elective CABG were examined. Study inclusion criteria were CABG performed on two and more coronary-vessels with aortic cross-clamp during 30-40 minutes. For assessment of patients objective health status before operations EuroSCORE were used. Serum uric acid (UA) levels and creatine phosphokinase (CPK) were measured spectrophotometricaly by using a quantitative enzymatic assay., Results: Carvedilol pretreated patients had higher amount of serum UA (p<0.05) comparing to non-treated patients. During the surgical procedure patients are subjected to temporary ischemia due to transfer from corporeal to extracorporeal circulation. In this period of time the amount of UA decreased in carvedilol pretreated group (406+/-46 (tl) vs. 300+/-22 mmol/L (t2)) to the level of non-treated patients (328+/-14 (t1) vs. 322+18 mmol/L. Carvedilol pretreated patients and non-treated patients had the same level of CPK at the beginning of the surgical procedure (tl) (78+/-6 vs. 83+13 U/L) but lower increase (p<0.05) in CPK activity in carvedilol pretreated patients in respect to non-treated patients (338+46 vs. 644+103 U/L) at the end of procedure (t2). Such results suggest that open heart surgery led to elevated CPK levels, but this effect was less pronounced in patients with higher level of UA., Conclusions: Our results suggest possible role of UA in the protection from reperfusion injury. Increase of UA before surgery may be beneficial factor during CABG procedure in patients treated with carvedilol by decreasing level of peroxynitrite as one of molecular causes of reperfusion injury. Our results showed influence of UA on CPK levels at the end of surgical procedure, indicating that increased levels of UA may protect heart from biochemical damage induced by peroxynitrite during the CABG intervention.

Background: Overproduction of nitric oxide (NO) and hydrogen peroxide (H(2)O(2)) may be an important factor in the pathogenesis of amyotrophic lateral sclerosis (ALS). Owing to their ability to permeate through biological membranes, excess NO and H(2)O(2) may be present in the media surrounding motor neurones. Anti-oxidative defence enzymes (ADEs) in erythrocytes are capable of detoxifying reactive oxygen species (produced endogenously or exogenously), but may also be structurally modified and inactivated by reactive oxygen and nitrogen species. Both balanced and coordinated ADE activities are of utmost importance for their correct physiological function., Methods: We determined activity of the following ADEs: copper-zinc superoxide dismutase (CuZn SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GR) in erythrocytes from sporadic ALS patients [SALS (-/+)], familial ALS patients with the Leu144Phe mutation in the SOD1 gene [FALS (+/+)], asymptomatic carriers with the Leu144Phe mutation in the SOD1 gene (+/-), and control subjects (-/-). We also examined the in vitro effect of diethyldithiocarbamate (DDC) on CuZn SOD activity in erythrocytes from FALS patients, SALS patients and control subjects., Results: The influence of the Leu144Phe mutation and/or disease was apparent for ADE activities measured in all three patient groups. The SOD1 gene mutation decreased CuZn SOD and GSH-Px activity (two-way ANOVA, significant mutation effect). We noted that the disease also contributed to decreased CuZn SOD activity in SALS patients in comparison with the control group (two-way ANOVA, mutation and disease effect). The disease also influenced CAT and GR activity. CAT activity was decreased in both SALS and FALS patients. In all three patient groups, GR activity was higher than in the control group. Finally, DDC inhibited CuZn SOD activity in erythrocytes from control subjects, FALS (Leu144Phe) patients and SALS patients; however, its effect was more pronounced and significant in FALS patients., Conclusions: Changes in erythrocyte ADE activities suggest that oxidative stress, involved in the motor neurone pathogenesis of SALS and FALS, also has systemic effects. Differences in ADE systems between the study groups revealed the presence of different types of oxidative pressure, indicating the potential additional benefit of individually designed anti-oxidant cocktail therapies.

Unlabelled: Aim of the study was to determine the time needed for establishing maximal labelled red blood cell concentration in hemangioma by scintigraphic semiquantitative blood pool estimation as a function of time., Patients and Methods: Eleven patients (eight females and three males) with total number of fourteen liver hemangiomas have been examined. Nine of them had solitary lesions and remaininig two patients had two and three liver hemangiomas, respectively. All patients underwent blood pool scintigraphy 40, 60, 120 and 180 minutes after in vivo labelling of autologous red blood cells using 740 MBq of 99mTc. After correction for radioactive decay of 99mTc and back-ground correction blood pool indexes, as hemangioma/heart and liver/heart counting rate ratios, have been calculated., Results: Mean blood pool indexes obtained 40-180 minutes after in vivo red blood cell labelling did not differ significantly (p > 0.05) neither in hemangioma (0.84-0.86) nor in liver tissue (0.55-0.58). In every acquisition time hemangioma blood pool index was substantialy higher than that of liver tissue (p < 0.01)., Conclusion: The results of the study indicates that labelled red blood cells concentration reaches its plateau before 40th minute following in vivo labelling. The concentration difference between hemangioma and liver tissue also does not differ significantly after 40th minute of blood pool examination. In most patients blood pool scintigrams taken 60, 120 and 180 minutes following in vivo RBC labelling do not contribute to diagnostic value of the method.

The aim is the assessment of the HP infection in stomach using breath test and comparison to other diagnostic methods, as well as following up the effect of therapy. In 83 patients with digestive discomfort rapid urease test, histology and breath test were performed, while in 25 patients with proven HP infection the effect of therapy was followed up using breath test and clinical findings. For rapid urease test and histology, samples were taken from antral mucosa. Breath test was performed after per oral administration of the capsule of 14C- urea (37 kBq) (Izotop, Hungary and Laboratory for radioactive isotopes, Vinca) which, in the presence of Helicobacter pylori breaks up to 14CO2 and NH3. Radioactivity was measured by beta counter in the exhaled air fasting and 30 minutes after ingestion of the capsule. According to our results, the rise of activity over 100% was considered positive. From 83 patients, 58 were breath test was positive, 24 negative and one equivocal. Fast urease test was in 54 positive, in 29 negative while histology was in 57 postitive and 26 negative. Findings of the breath and urease tests were in accordance in 93% patients while breath test and histology in 98% patients. During follow up of the therapeutic effects, breath test and clinical findings were in accordance in 98% patients. Breath test can be useful in diagnosis but is a method of choice in following up the patients after therapy for H. pylori infection, because it is non-invasive, fast and precise.

The aim of the study is detection and evaluation of the orthopedic infections using 99mTc-ciprofloxacin, radiopharmaceutical supposed to distinguish inflammation from infection. There were 15 true positive findings, 9 true negative, and two were false positive, while 1 was false negative. Sensitivity was 94%, specificity 82%, positive predictive value 88%, negative predictive value 90% and accuracy 89%. According to our results, scintigraphy with 99mTc-ciprofloxacin is a useful method for detection and assessment of exact localization of orthopedic infections, which might be useful for (differential) diagnosis, surgical treatment in due time as well as monitoring of the treatment of conservative therapy.

Nuclear medicine, diagnostic and therapeutic application of open sources of ionizing radiation in medicine, has wide range of possibilities for non-invasive infection and inflammation detection. The broad spectrum of methods, some of which are already in routine use while the others are still in the phase of investigation, improvement, or clinical trials, is presented. Most of the methods in routine use are capable of detection and localisation of both inflammation and infection. Antibiotic and antimicrobe peptides labelings have the possibility to diagnose infection and to differentiate it from inflammation, which is not the case with other scintigraphic methods. Availability of the radiopharmaceuticals and nuclear-medicine equipment, radiation exposure of the patient, clinical situation, the baseline pathophysiology of a process, and costs are the factors which contribute to the choice of the diagnostic approach. In order to ease the choice of the appropriate diagnostic method for inflammation/infection detection in different clinical situations, the recommendations from the ISORBE (International Society of Radiolabelled Blood Elements) are quoted.

The aim of the study is detection of the abdominal infective foci using 99mTc-ciprofloxacin, radiopharmaceutical supposed to distinguish inflammation from infection. Twenty-one patient was investigated. There were 11 true positive findings, 7 true negative, two were false negative, while 1 was false positive. Sensitivity of the method was 79% and specificity 91%. According to our results, scintigraphy with infection is a useful method for detection and assessment of exact localization of deep seated bacterial infections, which might be useful for (differential) diagnosis, surgical treatment in due time as well as monitoring of the treatment of conservative therapy.

The aim of the study is detection of the recurrences and metastases of colorectal carcinomas using (111)In labelled antibodies B72.3 in 14 patients. With tomography, we can access better distinction of tumour in comparison to other structures and estimation of its size. Other imaging methods (CT, US) have advantage in detection of liver metastases, while immunoscintigraphy is more specific for the assessment of malignant abdominal tumours and extrahepatic metastases. The first results point out that Oncoscint CR-103 can be useful in diagnosis of recurrences and metastases of colorectal carcinoma, viability assessment after radiotherapy and in the choice of the adequate surgical treatment in dependence of the spread of the disease.