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4 results on '"Davies, Samantha K."'

2. Microcalcification crystallography as a potential marker of DCIS recurrence

Author

Gosling, Sarah B, Arnold, Emily L, Davies, Samantha K, Cross, Hannah, Bouybayoune, Ihssane, Calabrese, Doriana, Nallala, Jayakrupakar, Pinder, Sarah E, Fu, Liping, Lips, Esther H, King, Lorraine, Marks, Jeffrey, Hall, Allison, Grimm, Lars J, Lynch, Thomas, Pinto, Donna, Stobart, Hilary, Hwang, E Shelley, Wesseling, Jelle, Geraki, Kalotina, Stone, Nicholas, Lyburn, Iain D, Greenwood, Charlene, Rogers, Keith D, Grand Challenge PRECISION Consortium, Gosling, Sarah B [0000-0002-7034-6547], Arnold, Emily L [0000-0001-5469-2071], Davies, Samantha K [0000-0002-1819-1904], Cross, Hannah [0000-0002-5339-4432], Bouybayoune, Ihssane [0000-0002-7185-1991], Calabrese, Doriana [0000-0002-3868-9830], Nallala, Jayakrupakar [0000-0002-9473-5782], and Apollo - University of Cambridge Repository

Subjects
Carcinoma, Intraductal, Noninfiltrating, Crystallography, Carcinoma, Ductal, Breast, Tumor Microenvironment, Humans, Calcinosis, Female, Breast Neoplasms, Neoplasm Recurrence, Local
Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

Published
2023

3. Microcalcification crystallography as a potential marker of DCIS recurrence

Author

Gosling, Sarah B., Arnold, Emily, and Davies, Samantha K.

Subjects
Biomineralization, Cancer microenvironment, Breast cancer, Biomarkers
Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20–25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation.

Published
2023

4. Microcalcification crystallography as a potential marker of DCIS recurrence.

Author

Gosling SB, Arnold EL, Davies SK, Cross H, Bouybayoune I, Calabrese D, Nallala J, Pinder SE, Fu L, Lips EH, King L, Marks J, Hall A, Grimm LJ, Lynch T, Pinto D, Stobart H, Hwang ES, Wesseling J, Geraki K, Stone N, Lyburn ID, Greenwood C, and Rogers KD

Subjects
Humans, Female, Crystallography, Neoplasm Recurrence, Local pathology, Tumor Microenvironment, Carcinoma, Intraductal, Noninfiltrating diagnostic imaging, Carcinoma, Intraductal, Noninfiltrating pathology, Carcinoma, Ductal, Breast pathology, Calcinosis diagnostic imaging, Calcinosis pathology, Breast Neoplasms diagnostic imaging, Breast Neoplasms pathology
Abstract

Ductal carcinoma in-situ (DCIS) accounts for 20-25% of all new breast cancer diagnoses. DCIS has an uncertain risk of progression to invasive breast cancer and a lack of predictive biomarkers may result in relatively high levels (~ 75%) of overtreatment. To identify unique prognostic biomarkers of invasive progression, crystallographic and chemical features of DCIS microcalcifications have been explored. Samples from patients with at least 5-years of follow up and no known recurrence (174 calcifications in 67 patients) or ipsilateral invasive breast cancer recurrence (179 microcalcifications in 57 patients) were studied. Significant differences were noted between the two groups including whitlockite relative mass, hydroxyapatite and whitlockite crystal maturity and, elementally, sodium to calcium ion ratio. A preliminary predictive model for DCIS to invasive cancer progression was developed from these parameters with an AUC of 0.797. These results provide insights into the differing DCIS tissue microenvironments, and how these impact microcalcification formation., (© 2023. The Author(s).)

Published
2023
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