1. microRNA-944 overexpression is a biomarker for poor prognosis of advanced cervical cancer
- Author
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Sunyoung Park, Jungho Kim, Kiyoon Eom, Sehee Oh, Sunghyun Kim, Geehyuk Kim, Sungwoo Ahn, Kwang Hwa Park, Dawn Chung, and Hyeyoung Lee
- Subjects
microRNAs ,Survival ,Prognosis ,Uterine cervical neoplasm ,Neoplasms. Tumors. Oncology. Including cancer and carcinogens ,RC254-282 - Abstract
Abstract Background One-third of cervical cancer patients are still diagnosed at advanced stages. The five-year survival rate is decreased in about 50% of advanced stage cervical cancer patients worldwide, and the clinical outcomes are remarkably varied and difficult to predict. One of the miRNAs known to be associated with cancer tumorigenesis is miR-944. However, the prognostic value of miR-944 in cervical cancer has not been fully investigated. The aim of this study was to analyze clinical significance and prognostic value of miR-944 in cervical cancer. Methods The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues. The association between the expression levels of miR-944 and prognostic value was analyzed using the Kaplan-Meier analysis and Cox proportional hazards model. Results The expression levels of miR-944 in cervical cancer tissues were significantly higher compared with those in normal tissues (P
- Published
- 2019
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