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BACKGROUND: Prolonged field care is a military adaptation of tactical combat casualty care providing extended prehospital management during delayed extrication. Effects of addition of valproic acid (VPA) to fresh-frozen plasma (FFP) in a prolonged field care model of hemorrhagic shock and traumatic brain injury are not known. We hypothesized that VPA is associated with decreased neurological impairment, and its protective changes are detected at the transcriptomic level. STUDY DESIGN: Swine underwent traumatic brain injury and 40% blood volume hemorrhage. After 2 hours of shock, they were randomized to (1) normal saline (NS), (2) NS + 250 mL FFP (NS + FFP), or (3) NS + FFP + 150 mg/kg VPA (NS + FFP + VPA). At 72 hours, they were transfused packed RBCs before being euthanized. Intraoperative variables and neurological outcomes were compared. Brain lesion size was measured, and gene expression profiles were analyzed using RNA sequencing. Pathway and network analyses were performed on differentially expressed genes. Real-time polymerase chain reaction was performed to validate key genes. RESULTS: NS + FFP and NS + FFP + VPA required significantly less crystalloid resuscitation (974 mL: NS + FFP; 1,461 mL: NS + FFP + VPA vs 4,540 mL: NS, p < 0.001), had smaller brain lesion size (2,477 mm3: NS + FFP; 3,018.0 mm3: NS + FFP + VPA vs 4,517.0 mm3: NS, p < 0.01), and required less functional neurologic impairment compared with NS. Per pathway analysis of differentially expressed genes, VPA was associated with enrichment of numerous metabolic changes in injured brains, which were not observed with FFP. Network analysis showed enrichment of various gene networks. Mitochondrially encoded ATP synthase membrane subunit 8 gene was downregulated in VPA-treated animals. CONCLUSIONS: The addition of FFP to the resuscitation protocol resulted in a significant reduction in crystalloid requirements. Both the NS + FFP and NS + FFP + VPA groups showed improved neurological recovery compared with NS alone and had distinctive transcriptomic profiles in injured brains at 72 hours. The mitochondrially encoded ATP synthase membrane subunit 8 gene, involved in worsening ischemia following brain injury, was downregulated in VPA-treated animals. [ABSTRACT FROM AUTHOR]

Introduction Prolonged Casualty Care (PCC) is a military adaptation aimed at providing pre-hospital care in austere settings when evacuation is delayed or even impossible. Current lack of standardized medical equipment and size/weight restrictions of military packs during dismounted operations hinder effective PCC. We sought to design a standardized, practical, and effective prolonged field care kit (PFAK) to enable widespread implementation of PCC. Materials and Methods We reviewed Joint Trauma System Clinical Practice Guidelines to generate a list of potential contents of the PFAK. We obtained Institutional Review Board (IRB) exemption and then conducted stakeholder surveys of combat casualty care experts across the Joint Trauma System using a modified Delphi survey approach. We established a civil–military working group that provided in-depth qualitative feedback on the PFAK contents and provided an initial design of a long-range medical rucksack (LMR) to house it. Responses were analyzed using mean rank scores to help determine initial components of the PFAK. Tactical subject-matter experts tested and evaluated the PFAK and LMR prototype in austere conditions to refine the design. Results Review of the PCC Clinical Practice Guidelines generated 49 medications and 301 potential supplies as potential PFAK contents. The first Delphi survey was sent to 100 stakeholders (overall response rate of 60%). After the first survey, contents were narrowed to a list of the most essential 27 medications and 105 other components. Iterative prototypes of the PFAK and LMR were tested to determine ergonomics, portability, flexibility, and equipment compartmentalization to facilitate use in emergencies. The prototype was optimized to address the clinical, logistical, and tactical requirements of PCC across a variety of platforms and environmental conditions. Conclusions Given the changing battlefield environment, efficient and effective PCC will play an increasingly important role in the management of combat trauma. The PFAK can meet this need by providing a practical and standardized resuscitation kit generated by expert military and trauma personnel consensus, carried conveniently in the LMR. [ABSTRACT FROM AUTHOR]

Introduction. We aimed to determine the burden of respiratory disease by examining clinical profiles and associated predictors of morbidity and mortality of patients admitted to a Pediatric Intensive Care Unit (PICU) in Pakistan, a resource limited country. We also stratified the respiratory diseases as defined by the Pediatric Advanced Life Support (PALS) Classification. Methods. A retrospective study was conducted on children aged 1 month to 18 years who were diagnosed with respiratory illness at the PICU in a tertiary hospital in Karachi, Pakistan. Demographics, essential clinical details including immunization status, and the outcome in terms of mortality or survival were recorded. Predictors of mortality and morbidity including prolonged intubation and mechanical ventilation in the PICU were analyzed using the chi‐square test or Fischer's exact test as appropriate. Results. 279 (63.8% male; median age 9 months, IQR 4–36 months) patients were evaluated of which 44.2% were malnourished and 23.3% were incompletely immunized. The median length of stay in the PICU was 3 days (IQR 2–5 days). Pneumonia was the principal diagnosis in 170 patients (62%) and accounted for most deaths. 76/279 (27.2%) were ventilated, and 67/279(24.0%) needed inotropic support. A high Pediatric Risk of Mortality (PRISM) III score, pneumothorax, and lower airway disease were significantly associated with ventilation support. The mortality rate of patients was 14.3%. Predictors of mortality were a high PRISM III score (OR 1.179; 95% CI 1.024–1.358, P = 0.022) and a positive blood culture (OR 4.305; 95% CI 1.062‐17.448, P = 0.041). Conclusion. Pneumonia is a significant contributor of respiratory diseases in the PICU in Pakistan and is the leading cause of morbidity and mortality. A high PRISM III score, pneumothorax, and lower airway disease were predictors for ventilation support. A high PRISM III score and a positive blood culture were predictors of patient mortality in our study. [ABSTRACT FROM AUTHOR]

This article explores the potential benefits of using fresh frozen plasma (FFP) as a treatment for traumatic brain injury (TBI). TBI is a significant global health issue, and current guidelines focus on minimizing secondary brain injury. FFP has shown promise in improving survival rates and may have neuroprotective effects in TBI patients. Animal models and clinical studies have demonstrated that early administration of FFP can reduce brain lesion size, improve neurological outcomes, and enhance survival rates. The FIT-BRAIN clinical trial, funded by the Department of Defense, aims to evaluate the safety and efficacy of early FFP administration in patients with moderate to severe TBI. The trial will compare outcomes between patients who receive FFP and those who receive standard care alone, with the primary endpoint being the Extended Glasgow Outcome Scale (GOS-E) at 3 months post-injury. The trial will collect data on secondary and exploratory endpoints, including hemorrhagic progression of contusion, disability rating score, and intracranial pressure readings. The study has been designed to minimize biases and ensure diverse representation by selecting geographically distinct research sites. The authors hope that the trial will provide valuable information about the benefits of early plasma administration in TBI patients and potentially lead to a new treatment option for brain injuries. [Extracted from the article]

BACKGROUND: We have previously shown that partial REBOA (pREBOA) deployment in the thoracic aorta is safe for 2 to 4 hours, but it is unclear whether the distal blood flow after partial aortic occlusion would lead to ongoing hemorrhage. The objective of this study was to evaluate the hemostatic efficacy of pREBOA in a model of uncontrolled vascular injury. STUDY DESIGN: Female Yorkshire swine (n = 10, 40 to 45 kg) were anesthetized and instrumented. A throughand- through injury was created in the common iliac artery. The animals were randomly assigned to: (1) pREBOA-PRO deployment after 3 minutes and (2) control. Both groups were given normal saline resuscitation for hypotension. The pREBOA was adjusted to partial occlusion (distal mean arterial pressure of 30 mmHg), and then left without titration for 2 hours. Then, fresh frozen plasma was transfused and the vessel repaired. The balloon was deflated and the animals were monitored for 2 hours. In the critical care period, 2 L of normal saline was infused, norepinephrine was given for mean arterial pressure ≤55, and electrolytes and acidosis were corrected. Organs were examined for gross and histologic evidence of ischemic injuries. The primary endpoint was post-inflation blood loss. RESULTS: All the pREBOA animals survived until the end, whereas control animals had a mean survival time of 38.2 minutes (p < 0.05). The pREBOA group showed significantly less bleeding after balloon deployment (93.8 vs 1,980.0 mL, p < 0.05), and had appropriate lactate clearance, with minimal histologic distal organ ischemia. CONCLUSIONS: Partial aortic occlusion with the newly designed balloon can achieve the desired balance between effective hemorrhage control and adequate distal flow, without a need for ongoing balloon titration. [ABSTRACT FROM AUTHOR]