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1,876 results on '"Day, Nicholas P. J."'

1. Population genomics and transcriptomics of Plasmodium falciparum in Cambodia and Vietnam uncover key components of the artemisinin resistance genetic background

Author

Nayak, Sourav, Peto, Thomas J., Kucharski, Michal, Tripura, Rupam, Callery, James J., Quang Huy, Duong Tien, Gendrot, Mathieu, Lek, Dysoley, Nghia, Ho Dang Trung, van der Pluijm, Rob W., Dong, Nguyen, Long, Le Thanh, Vongpromek, Ranitha, Rekol, Huy, Hoang Chau, Nguyen, Miotto, Olivo, Mukaka, Mavuto, Dhorda, Mehul, von Seidlein, Lorenz, Imwong, Mallika, Roca, Xavier, Day, Nicholas P. J., White, Nicholas J., Dondorp, Arjen M., and Bozdech, Zbynek

Published
2024
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4. A randomised trial of malaria vaccine R21/Matrix-M™ with and without antimalarial drugs in Thai adults

Author

Hanboonkunupakarn, Borimas, Mukaka, Mavuto, Jittamala, Podjanee, Poovorawan, Kittiyod, Pongsuwan, Pongphaya, Stockdale, Lisa, Provstgaard-Morys, Samuel, Chotivanich, Kesinee, Tarning, Joel, Hoglund, Richard M., Chimjinda, Natenapa, Ewer, Katie, Ramos-Lopez, Fernando, Day, Nicholas P. J., Dondorp, Arjen M., Hill, Adrian V., White, Nicholas J., von Seidlein, Lorenz, and Pukrittayakamee, Sasithon

Published
2024
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6. Clinical antiviral efficacy of favipiravir in early COVID-19 (PLATCOV): an open-label, randomised, controlled, adaptive platform trial

Author

Luvira, Viravarn, Schilling, William H. K., Jittamala, Podjanee, Watson, James A., Boyd, Simon, Siripoon, Tanaya, Ngamprasertchai, Thundon, Almeida, Pedro J., Ekkapongpisit, Maneerat, Cruz, Cintia, Callery, James J., Singh, Shivani, Tuntipaiboontana, Runch, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad Yazid, Keayarsa, Srisuda, Madmanee, Wanassanan, Aguiar, Renato S., Santos, Franciele M., Hanboonkunupakarn, Pongtorn, Hanboonkunupakarn, Borimas, Poovorawan, Kittiyod, Imwong, Mallika, Taylor, Walter R. J., Chotivanich, Vasin, Chotivanich, Kesinee, Pukrittayakamee, Sasithon, Dondorp, Arjen M., Day, Nicholas P. J., Teixeira, Mauro M., Piyaphanee, Watcharapong, Phumratanaprapin, Weerapong, and White, Nicholas J.

Published
2024
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7. Methaemoglobin as a surrogate marker of primaquine antihypnozoite activity in Plasmodium vivax malaria: A systematic review and individual patient data meta-analysis

Author

Fadilah, Ihsan, Commons, Robert J., Chau, Nguyen Hoang, Chu, Cindy S., Day, Nicholas P. J., Koh, Gavin C. K. W., Green, Justin A., Lacerda, Marcus VG, Llanos-Cuentas, Alejandro, Nelwan, Erni J., Nosten, Francois, Pasaribu, Ayodhia Pitaloka, Sutanto, Inge, Taylor, Walter R. J., Thriemer, Kamala, Price, Ric N., White, Nicholas J., Baird, J. Kevin, and Watson, James A.

Subjects
Hemoglobin -- Measurement -- Health aspects, Diseases -- Relapse, Primaquine -- Dosage and administration -- Physiological aspects, Malaria -- Drug therapy, Biological sciences
Abstract

Background The 8-aminoquinolines, primaquine and tafenoquine, are the only available drugs for the radical cure of Plasmodium vivax hypnozoites. Previous evidence suggests that there is dose-dependent 8-aminoquinoline induced methaemoglobinaemia and that higher methaemoglobin concentrations are associated with a lower risk of P. vivax recurrence. We undertook a systematic review and individual patient data meta-analysis to examine the utility of methaemoglobin as a population-level surrogate endpoint for 8-aminoquinoline antihypnozoite activity to prevent P. vivax recurrence. Methods and findings We conducted a systematic search of Medline, Embase, Web of Science, and the Cochrane Library, from 1 January 2000 to 29 September 2022, inclusive, of prospective clinical efficacy studies of acute, uncomplicated P. vivax malaria mono-infections treated with radical curative doses of primaquine. The day 7 methaemoglobin concentration was the primary surrogate outcome of interest. The primary clinical outcome was the time to first P. vivax recurrence between day 7 and day 120 after enrolment. We used multivariable Cox proportional-hazards regression with site random-effects to characterise the time to first recurrence as a function of the day 7 methaemoglobin percentage (log base 2 transformed), adjusted for the partner schizonticidal drug, the primaquine regimen duration as a proxy for the total primaquine dose (mg base/kg), the daily primaquine dose (mg/kg), and other factors. The systematic review protocol was registered with PROSPERO (CRD42023345956). We identified 219 P. vivax efficacy studies, of which 8 provided relevant individual-level data from patients treated with primaquine; all were randomised, parallel arm clinical trials assessed as having low or moderate risk of bias. In the primary analysis data set, there were 1,747 patients with normal glucose-6-phosphate dehydrogenase (G6PD) activity enrolled from 24 study sites across 8 different countries (Indonesia, Brazil, Vietnam, Thailand, Peru, Colombia, Ethiopia, and India). We observed an increasing dose-response relationship between the daily weight-adjusted primaquine dose and day 7 methaemoglobin level. For a given primaquine dose regimen, an observed doubling in day 7 methaemoglobin percentage was associated with an estimated 30% reduction in the risk of P. vivax recurrence (adjusted hazard ratio = 0.70; 95% confidence interval [CI] [0.57, 0.86]; p = 0.0005). These pooled estimates were largely consistent across the study sites. Using day 7 methaemoglobin as a surrogate endpoint for recurrence would reduce required sample sizes by approximately 40%. Study limitations include the inability to distinguish between recrudescence, reinfection, and relapse in P. vivax recurrences. Conclusions For a given primaquine regimen, higher methaemoglobin on day 7 was associated with a reduced risk of P. vivax recurrence. Under our proposed causal model, this justifies the use of methaemoglobin as a population-level surrogate endpoint for primaquine antihypnozoite activity in patients with P. vivax malaria who have normal G6PD activity., Author(s): Ihsan Fadilah 1,2,*, Robert J. Commons 3,4,5, Nguyen Hoang Chau 6, Cindy S. Chu 2,7, Nicholas P. J. Day 2,8, Gavin C. K. W. Koh 9, Justin A. Green [...]

Published
2024
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8. Evaluation of hydroxychloroquine or chloroquine for the prevention of COVID-19 (COPCOV): A double-blind, randomised, placebo-controlled trial

Author

Schilling, William H. K., Mukaka, Mavuto, Callery, James J., Llewelyn, Martin J., Cruz, Cintia V., Dhorda, Mehul, Ngernseng, Thatsanun, Waithira, Naomi, Ekkapongpisit, Maneerat, Watson, James A., Chandna, Arjun, Nelwan, Erni J., Hamers, Raph L., Etyang, Anthony, Beg, Mohammad Asim, Sow, Samba, Yavo, William, Allabi, Aurel Constant, Basnyat, Buddha, Sharma, Sanjib Kumar, Amofa-Sekyi, Modupe, Yonga, Paul, Adler, Amanda, Yuentrakul, Prayoon, Cope, Tanya, Thaipadungpanit, Janjira, Rienpradub, Panuvit, Imwong, Mallika, Abdad, Mohammad Yazid, Blacksell, Stuart D., Tarning, Joel, Goudjo, Frejus Faustin, Dossou, Ange D., Konaté-Touré, Abibatou, Assi, Serge-Brice, Ouffoué, Kra, Nasronudin, Nasronudin, Rachman, Brian Eka, Romadhon, Pradana Zaky, Dewanto, Didi Darmahadi, Heryana, Made Oka, Novi, Theresia, Pasaribu, Ayodhia Pitaloka, Mutiara, Mutiara, Nasution, Miranda Putri Rahayu, Khairunnisa, Khairunnisa, Dalimunthe, Fauzan Azima, Airlangga, Eka, Fahrezzy, Akmal, Subronto, Yanri, Ananda, Nur Rahmi, Rahardjani, Mutia, Rimainar, Atika, Lucinde, Ruth Khadembu, Timbwa, Molline, Onyango, Otieno Edwin, Agutu, Clara, Akech, Samuel, Hamaluba, Mainga, Kipyego, Jairus, Ngachi, Obadiah, Haidara, Fadima Cheick, Traoré, Oumar Y., Diarra, François, Khanal, Basudha, Dahal, Piyush, Shrestha, Suchita, Rijal, Samita, Kabore, Youssouf, Adehossi, Eric, Guindo, Ousmane, Qamar, Farah Naz, Kazi, Abdul Momin, Woodrow, Charles J., Laird, Steven, Cheeba, Maina, Ayles, Helen, Cheah, Phaik Yeong, Taylor, Walter R. J., Batty, Elizabeth M., Chotivanich, Kesinee, Pukrittayakamee, Sasithon, Phumratanaprapin, Weerapong, von Seidlein, Lorenz, Dondorp, Arjen, Day, Nicholas P. J., and White, Nicholas J.

Subjects
Hydroxychloroquine -- Testing, Chloroquine -- Testing, Biological sciences
Abstract

Background Hydroxychloroquine (HCQ) has proved ineffective in treating patients hospitalised with Coronavirus Disease 2019 (COVID-19), but uncertainty remains over its safety and efficacy in chemoprevention. Previous chemoprevention randomised controlled trials (RCTs) did not individually show benefit of HCQ against COVID-19 and, although meta-analysis did suggest clinical benefit, guidelines recommend against its use. Methods and findings Healthy adult participants from the healthcare setting, and later from the community, were enrolled in 26 centres in 11 countries to a double-blind, placebo-controlled, randomised trial of COVID-19 chemoprevention. HCQ was evaluated in Europe and Africa, and chloroquine (CQ) was evaluated in Asia, (both base equivalent of 155 mg once daily). The primary endpoint was symptomatic COVID-19, confirmed by PCR or seroconversion during the 3-month follow-up period. The secondary and tertiary endpoints were: asymptomatic laboratory-confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection; severity of COVID-19 symptoms; all-cause PCR-confirmed symptomatic acute respiratory illness (including SARS-CoV-2 infection); participant reported number of workdays lost; genetic and baseline biochemical markers associated with symptomatic COVID-19, respiratory illness and disease severity (not reported here); and health economic analyses of HCQ and CQ prophylaxis on costs and quality of life measures (not reported here). The primary and safety analyses were conducted in the intention-to-treat (ITT) population. Recruitment of 40,000 (20,000 HCQ arm, 20,000 CQ arm) participants was planned but was not possible because of protracted delays resulting from controversies over efficacy and adverse events with HCQ use, vaccine rollout in some countries, and other factors. Between 29 April 2020 and 10 March 2022, 4,652 participants (46% females) were enrolled (HCQ/CQ n = 2,320; placebo n = 2,332). The median (IQR) age was 29 (23 to 39) years. SARS-CoV-2 infections (symptomatic and asymptomatic) occurred in 1,071 (23%) participants. For the primary endpoint the incidence of symptomatic COVID-19 was 240/2,320 in the HCQ/CQ versus 284/2,332 in the placebo arms (risk ratio (RR) 0.85 [95% confidence interval, 0.72 to 1.00; p = 0.05]). For the secondary and tertiary outcomes asymptomatic SARS-CoV-2 infections occurred in 11.5% of HCQ/CQ recipients and 12.0% of placebo recipients: RR: 0.96 (95% CI, 0.82 to 1.12; p = 0.6). There were no differences in the severity of symptoms between the groups and no severe illnesses. HCQ/CQ chemoprevention was associated with fewer PCR-confirmed all-cause respiratory infections (predominantly SARS-CoV-2): RR 0.61 (95% CI, 0.42 to 0.88; p = 0.009) and fewer days lost to work because of illness: 104 days per 1,000 participants over 90 days (95% CI, 12 to 199 days; p < 0.001). The prespecified meta-analysis of all published pre-exposure RCTs indicates that HCQ/CQ prophylaxis provided a moderate protective benefit against symptomatic COVID-19: RR 0.80 (95% CI, 0.71 to 0.91). Both drugs were well tolerated with no drug-related serious adverse events (SAEs). Study limitations include the smaller than planned study size, the relatively low number of PCR-confirmed infections, and the lower comparative accuracy of serology endpoints (in particular, the adapted dried blood spot method) compared to the PCR endpoint. The COPCOV trial was registered with ClinicalTrials.gov; number NCT04303507. Interpretation In this large placebo-controlled, double-blind randomised trial, HCQ and CQ were safe and well tolerated in COVID-19 chemoprevention, and there was evidence of moderate protective benefit in a meta-analysis including this trial and similar RCTs. Trial registration ClinicalTrials.gov NCT04303507; ISRCTN Registry ISRCTN10207947., Author(s): William H. K. Schilling 1,2,*, Mavuto Mukaka 1,2, James J. Callery 1,2, Martin J. Llewelyn 3,4, Cintia V. Cruz 1,2, Mehul Dhorda 1,2, Thatsanun Ngernseng 1, Naomi Waithira 1,2, [...]

Published
2024
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9. Temporal changes in SARS-CoV-2 clearance kinetics and the optimal design of antiviral pharmacodynamic studies: an individual patient data meta-analysis of a randomised, controlled, adaptive platform study (PLATCOV)

Author

Callery, James, Cruz, Cintia, Taylor, Walter, Thaipadungpanit, Janjira, Ekkapongpisit, Maneerat, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad, Keayarsa, Srisuda, Anunsittichai, Orawan, Hongsuwan, Maliwan, Singhaboot, Yutatirat, Madmanee, Wanassanan, Tuntipaiboontana, Runch, Promsongsil, Amornrat, Saroj, Manisaree, Suwannasin, Kanokon, Beer, Ellen, Asawasriworanan, Tanatchakorn, Blacksell, Stuart, Panapipat, Salwaluk, Waithira, Naomi, Tarning, Joel, Tanglakmankhong, Nuttakan, Almeida, Pedro J, Aguiar, Renato S, Ascencao, Fernando, Esper, Lisia, Vongsouvath, Manivanh, Phommasone, Koukeo, Dubot-Pérès, Audrey, Vidhamaly, Sisouphanh, Chingsanoon, Ammala, Bisayher, Sixiong, Chommanam, Danoy, Evans, Terry, Vidhamaly, Vayouly, Boutthasavong, Latsaniphone, Vongphachanh, Susath, Potaporn, Manus, Srisubat, Attasit, Loharjun, Bootsakorn, Beg, M Asim, Kazi, Abdul Momin, Qamar, Farah, Ghanchi, Najia, Mahmood, Syed Faisal, Hanboonkunupakarn, Pongtorn, Sookprome, Sakol, Chotivanich, Vasin, Ruksakul, Wiroj, Sangketchon, Chunlanee, Wongnak, Phrutsamon, Schilling, William H K, Jittamala, Podjanee, Boyd, Simon, Luvira, Viravarn, Siripoon, Tanaya, Ngamprasertchai, Thundon, Batty, Elizabeth M, Singh, Shivani, Kouhathong, Jindarat, Pagornrat, Watcharee, Khanthagan, Patpannee, Hanboonkunupakarn, Borimas, Poovorawan, Kittiyod, Mayxay, Mayfong, Chotivanich, Kesinee, Imwong, Mallika, Pukrittayakamee, Sasithon, Ashley, Elizabeth A, Dondorp, Arjen M, Day, Nicholas P J, Teixeira, Mauro M, Piyaphanee, Watcharapong, Phumratanaprapin, Weerapong, White, Nicholas J, and Watson, James A

Published
2024
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10. Benchmarking CRISPR-BP34 for point-of-care melioidosis detection in low-income and middle-income countries: a molecular diagnostics study

Author

Pakdeerat, Sukripong, Boonklang, Phumrapee, Angchagun, Kesorn, Chomkatekaew, Chalita, Apichaidejudom, Navaporn, Dokket, Yaowaret, Faosap, Areeya, Wongsuwan, Gumphol, Wuthiekanun, Vanaporn, Aramrueung, Panatda, Khamnoi, Phadungkiat, Thananchai, Hathairat, Siriboon, Suwattiya, Chamnan, Parinya, Peacock, Sharon J, Day, Nicholas P J, Thomson, Nicholas R, Uttamapinant, Chayasith, Wongpalee, Somsakul Pop, and Chewapreecha, Claire

Published
2024
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11. Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial

Author

White, Nicholas J, Schilling, William HK, Phumratanaprapin, Weerapong, Luvira, Viravarn, Callery, James J, Day, Nicholas PJ, Pukrittayakamee, Sasithon, Boyd, Simon, Cruz, Cintia, Dondorp, Arjen M, Taylor, Walter RJ, Watson, James A, Piyaphanee, Watcharapong, Poovorawan, Kittiyod, Ngamprasertchai, Thundon, Siripoon, Tanaya, Hanboonkunupakarn, Borimas, Chotivanich, Kesinee, Jittamala, Podjanee, Imwong, Mallika, Thaipadungpanit, Janjira, Ekkapongpisit, Maneerat, Kruabkontho, Varaporn, Ngernseng, Thatsanun, Tubprasert, Jaruwan, Abdad, Mohammad Yazid, Batty, Elizabeth M, Singh, Shivani, Chotivanich, Vasin, Ruksakul, Wiroj, Sangketchon, Chunlanee, Hanboonkunupakarn, Pongtorn, Sookprome, Sakol, Teixeira, Mauro, Almeida, Pedro J, Aguiar, Renato S, Santos, Franciele, Ashley, Elizabeth, Vongsouvath, Manivanh, Phommasone, Koukeo, Dubot-Pérès, Audrey, Vidhamaly, Sisouphanh, Chingsanoon, Ammala, Bisayher, Sixiong, Chommanam, Danoy, Evans, Terry John, Vidhamaly, Vayouly, Boutthasavong, Latsaniphone, Mayxay, Mayfong, Potaporn, Manus, Srisubat, Attasit, Loharjun, Bootsakorn, Schilling, William H K, Saroj, Manisaree, Tanglakmankhong, Nuttakan, Madmanee, Wanassanan, Kouhathong, Jindarat, Suwannasin, Kanokon, Pagornrat, Watcharee, Piaraksa, Nattaporn, Taylor, Walter R J, Day, Nicholas P J, and Teixeira, Mauro M

Published
2024
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12. Factors affecting haemoglobin dynamics in African children with acute uncomplicated Plasmodium falciparum malaria treated with single low-dose primaquine or placebo

Author

Onyamboko, Marie A., Olupot-Olupot, Peter, Were, Winifred, Namayanja, Cate, Onyas, Peter, Titin, Harriet, Baseke, Joy, Muhindo, Rita, Kayembe, Daddy K., Ndjowo, Pauline O., Basara, Benjamin B., Okalebo, Charles B., Williams, Thomas N., Uyoga, Sophie, Taya, Chiraporn, Bamisaiye, Adeola, Fanello, Caterina, Maitland, Kathryn, Day, Nicholas P. J., Taylor, Walter R. J., and Mukaka, Mavuto

Published
2023
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13. Urinary catecholamine excretion, cardiovascular variability, and outcomes in tetanus

Author

Du, Duc Hong, Hao, Nguyen Quan Nhu, Van Hao, Nguyen, Thanh, Tran Tan, Loan, Huynh Thi, Yen, Lam Minh, Thuy, Tran Thi Diem, Thuy, Duong Bich, Nguyen, Nguyen Thanh, Dung, Nguyen Thi Phuong, Kestelyn, Evelyne, Duong, Ha Thi Hai, Phong, Nguyen Thanh, Tuyen, Pham Thi, Phu, Nguyen Hoan, Nghia, Ho Dang Trung, Hanh, Bui Thi Bich, Oanh, Pham Kieu Nguyet, Tho, Phan Vinh, Nhat, Phung Tran Huy, Khanh, Phan Nguyen Quoc, Wyncoll, Duncan, Day, Nicholas P. J., Van Vinh Chau, Nguyen, van Doorn, H. Rogier, Van Tan, Le, Geskus, Ronald B., and Thwaites, C. Louise

Published
2023
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15. Triple therapy with artemether–lumefantrine plus amodiaquine versus artemether–lumefantrine alone for artemisinin-resistant, uncomplicated falciparum malaria: an open-label, randomised, multicentre trial

Author

Peto, Thomas J, Tripura, Rupam, Callery, James J, Lek, Dysoley, Nghia, Ho Dang Trung, Nguon, Chea, Thuong, Nguyen Thi Huyen, van der Pluijm, Rob W, Dung, Nguyen Thi Phuong, Sokha, Meas, Van Luong, Vo, Long, Le Thanh, Sovann, Yok, Duanguppama, Jureeporn, Waithira, Naomi, Hoglund, Richard M, Chotsiri, Palang, Chau, Nguyen Hoang, Ruecker, Andrea, Amaratunga, Chanaki, Dhorda, Mehul, Miotto, Olivo, Maude, Richard J, Rekol, Huy, Chotivanich, Kesinee, Tarning, Joel, von Seidlein, Lorenz, Imwong, Mallika, Mukaka, Mavuto, Day, Nicholas P J, Hien, Tran Tinh, White, Nicholas J, and Dondorp, Arjen M

Published
2022
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16. Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis

Author

Murray, Christopher J L, Ikuta, Kevin Shunji, Sharara, Fablina, Swetschinski, Lucien, Robles Aguilar, Gisela, Gray, Authia, Han, Chieh, Bisignano, Catherine, Rao, Puja, Wool, Eve, Johnson, Sarah C, Browne, Annie J, Chipeta, Michael Give, Fell, Frederick, Hackett, Sean, Haines-Woodhouse, Georgina, Kashef Hamadani, Bahar H, Kumaran, Emmanuelle A P, McManigal, Barney, Achalapong, Sureeruk, Agarwal, Ramesh, Akech, Samuel, Albertson, Samuel, Amuasi, John, Andrews, Jason, Aravkin, Aleskandr, Ashley, Elizabeth, Babin, François-Xavier, Bailey, Freddie, Baker, Stephen, Basnyat, Buddha, Bekker, Adrie, Bender, Rose, Berkley, James A, Bethou, Adhisivam, Bielicki, Julia, Boonkasidecha, Suppawat, Bukosia, James, Carvalheiro, Cristina, Castañeda-Orjuela, Carlos, Chansamouth, Vilada, Chaurasia, Suman, Chiurchiù, Sara, Chowdhury, Fazle, Clotaire Donatien, Rafai, Cook, Aislinn J, Cooper, Ben, Cressey, Tim R, Criollo-Mora, Elia, Cunningham, Matthew, Darboe, Saffiatou, Day, Nicholas P J, De Luca, Maia, Dokova, Klara, Dramowski, Angela, Dunachie, Susanna J, Duong Bich, Thuy, Eckmanns, Tim, Eibach, Daniel, Emami, Amir, Feasey, Nicholas, Fisher-Pearson, Natasha, Forrest, Karen, Garcia, Coralith, Garrett, Denise, Gastmeier, Petra, Giref, Ababi Zergaw, Greer, Rachel Claire, Gupta, Vikas, Haller, Sebastian, Haselbeck, Andrea, Hay, Simon I, Holm, Marianne, Hopkins, Susan, Hsia, Yingfen, Iregbu, Kenneth C, Jacobs, Jan, Jarovsky, Daniel, Javanmardi, Fatemeh, Jenney, Adam W J, Khorana, Meera, Khusuwan, Suwimon, Kissoon, Niranjan, Kobeissi, Elsa, Kostyanev, Tomislav, Krapp, Fiorella, Krumkamp, Ralf, Kumar, Ajay, Kyu, Hmwe Hmwe, Lim, Cherry, Lim, Kruy, Limmathurotsakul, Direk, Loftus, Michael James, Lunn, Miles, Ma, Jianing, Manoharan, Anand, Marks, Florian, May, Jürgen, Mayxay, Mayfong, Mturi, Neema, Munera-Huertas, Tatiana, Musicha, Patrick, Musila, Lilian A, Mussi-Pinhata, Marisa Marcia, Naidu, Ravi Narayan, Nakamura, Tomoka, Nanavati, Ruchi, Nangia, Sushma, Newton, Paul, Ngoun, Chanpheaktra, Novotney, Amanda, Nwakanma, Davis, Obiero, Christina W, Ochoa, Theresa J, Olivas-Martinez, Antonio, Olliaro, Piero, Ooko, Ednah, Ortiz-Brizuela, Edgar, Ounchanum, Pradthana, Pak, Gideok D, Paredes, Jose Luis, Peleg, Anton Yariv, Perrone, Carlo, Phe, Thong, Phommasone, Koukeo, Plakkal, Nishad, Ponce-de-Leon, Alfredo, Raad, Mathieu, Ramdin, Tanusha, Rattanavong, Sayaphet, Riddell, Amy, Roberts, Tamalee, Robotham, Julie Victoria, Roca, Anna, Rosenthal, Victor Daniel, Rudd, Kristina E, Russell, Neal, Sader, Helio S, Saengchan, Weerawut, Schnall, Jesse, Scott, John Anthony Gerard, Seekaew, Samroeng, Sharland, Mike, Shivamallappa, Madhusudhan, Sifuentes-Osornio, Jose, Simpson, Andrew J, Steenkeste, Nicolas, Stewardson, Andrew James, Stoeva, Temenuga, Tasak, Nidanuch, Thaiprakong, Areerat, Thwaites, Guy, Tigoi, Caroline, Turner, Claudia, Turner, Paul, van Doorn, H Rogier, Velaphi, Sithembiso, Vongpradith, Avina, Vongsouvath, Manivanh, Vu, Huong, Walsh, Timothy, Walson, Judd L, Waner, Seymour, Wangrangsimakul, Tri, Wannapinij, Prapass, Wozniak, Teresa, Young Sharma, Tracey E M W, Yu, Kalvin C, Zheng, Peng, Sartorius, Benn, Lopez, Alan D, Stergachis, Andy, Moore, Catrin, Dolecek, Christiane, and Naghavi, Mohsen

Published
2022
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17. Correction: Assessing the impact of a novel house design on the incidence of malaria in children in rural Africa: study protocol for a household-cluster randomized controlled superiority trial

Author

Mshamu, Salum, Mmbando, Arnold, Meta, Judith, Bradley, John, Bøjstrup, Thomas Chevalier, Day, Nicholas P. J., Mukaka, Mavuto, Okumu, Fredros, Olotu, Ally, Pell, Christopher, Deen, Jacqueline, Knudsen, Jakob, Lindsay, Steven W., and von Seidlein, Lorenz

Published
2022
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24. Artemisinin resistance in the malaria parasite, Plasmodium falciparum, originates from its initial transcriptional response

Author

Zhu, Lei, van der Pluijm, Rob W., Kucharski, Michal, Nayak, Sourav, Tripathi, Jaishree, White, Nicholas J., Day, Nicholas P. J., Faiz, Abul, Phyo, Aung Pyae, Amaratunga, Chanaki, Lek, Dysoley, Ashley, Elizabeth A., Nosten, François, Smithuis, Frank, Ginsburg, Hagai, von Seidlein, Lorenz, Lin, Khin, Imwong, Mallika, Chotivanich, Kesinee, Mayxay, Mayfong, Dhorda, Mehul, Nguyen, Hoang Chau, Nguyen, Thuy Nhien Thanh, Miotto, Olivo, Newton, Paul N., Jittamala, Podjanee, Tripura, Rupam, Pukrittayakamee, Sasithon, Peto, Thomas J., Hien, Tran Tinh, Dondorp, Arjen M., and Bozdech, Zbynek

Published
2022
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27. Mass drug administration for the acceleration of malaria elimination in a region of Myanmar with artemisinin-resistant falciparum malaria: a cluster-randomised trial

Author

McLean, Alistair R D, Indrasuta, Chanida, Khant, Zay Soe, Phyo, Aung Kyaw, Maung, Sai Maung, Heaton, James, Aung, Hein, Aung, Ye, Soe, Kyaw, Swe, Myo Maung Maung, von Seidlein, Lorenz, Tun, Ni Ni, Tun, Kyaw Myo, Day, Nicholas P J, Ashley, Elizabeth A, Hlaing, Thaung, Kyaw, Thar Tun, Dondorp, Arjen M, Imwong, Mallika, White, Nicholas J, and Smithuis, Frank M

Published
2021
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28. Arterolane–piperaquine–mefloquine versus arterolane–piperaquine and artemether–lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Kenyan children: a single-centre, open-label, randomised, non-inferiority trial

Author

Hamaluba, Mainga, van der Pluijm, Rob W, Weya, Joseph, Njuguna, Patricia, Ngama, Mwanajuma, Kalume, Peter, Mwambingu, Gabriel, Ngetsa, Caroline, Wambua, Juliana, Boga, Mwanamvua, Mturi, Neema, Lal, Altaf A, Khuroo, Arshad, Taylor, Walter R J, Gonçalves, Sónia, Miotto, Olivo, Dhorda, Mehul, Mutinda, Brian, Mukaka, Mavuto, Waithira, Naomi, Hoglund, Richard M, Imwong, Mallika, Tarning, Joel, Day, Nicholas P J, White, Nicholas J, Bejon, Philip, and Dondorp, Arjen M

Published
2021
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29. Molecular epidemiology of resistance to antimalarial drugs in the Greater Mekong subregion: an observational study

Author

Imwong, Mallika, Dhorda, Mehul, Myo Tun, Kyaw, Thu, Aung Myint, Phyo, Aung Pyae, Proux, Stephane, Suwannasin, Kanokon, Kunasol, Chanon, Srisutham, Suttipat, Duanguppama, Jureeporn, Vongpromek, Ranitha, Promnarate, Cholrawee, Saejeng, Aungkana, Khantikul, Nardlada, Sugaram, Rungniran, Thanapongpichat, Supinya, Sawangjaroen, Nongyao, Sutawong, Kreepol, Han, Kay Thwe, Htut, Ye, Linn, Khin, Win, Aye Aye, Hlaing, Tin M, van der Pluijm, Rob W, Mayxay, Mayfong, Pongvongsa, Tiengkham, Phommasone, Koukeo, Tripura, Rupam, Peto, Thomas J, von Seidlein, Lorenz, Nguon, Chea, Lek, Dysoley, Chan, Xin Hui S, Rekol, Huy, Leang, Rithea, Huch, Cheah, Kwiatkowski, Dominic P, Miotto, Olivo, Ashley, Elizabeth A, Kyaw, Myat Phone, Pukrittayakamee, Sasithon, Day, Nicholas P J, Dondorp, Arjen M, Smithuis, Frank M, Nosten, Francois H, and White, Nicholas J

Published
2020
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30. Triple artemisinin-based combination therapies versus artemisinin-based combination therapies for uncomplicated Plasmodium falciparum malaria: a multicentre, open-label, randomised clinical trial

Author

van der Pluijm, Rob W, Tripura, Rupam, Hoglund, Richard M, Phyo, Aung Pyae, Lek, Dysoley, ul Islam, Akhter, Anvikar, Anupkumar R, Satpathi, Parthasarathi, Satpathi, Sanghamitra, Behera, Prativa Kumari, Tripura, Amar, Baidya, Subrata, Onyamboko, Marie, Chau, Nguyen Hoang, Sovann, Yok, Suon, Seila, Sreng, Sokunthea, Mao, Sivanna, Oun, Savuth, Yen, Sovannary, Amaratunga, Chanaki, Chutasmit, Kitipumi, Saelow, Chalermpon, Runcharern, Ratchadaporn, Kaewmok, Weerayuth, Hoa, Nhu Thi, Thanh, Ngo Viet, Hanboonkunupakarn, Borimas, Callery, James J, Mohanty, Akshaya Kumar, Heaton, James, Thant, Myo, Gantait, Kripasindhu, Ghosh, Tarapada, Amato, Roberto, Pearson, Richard D, Jacob, Christopher G, Gonçalves, Sónia, Mukaka, Mavuto, Waithira, Naomi, Woodrow, Charles J, Grobusch, Martin P, van Vugt, Michele, Fairhurst, Rick M, Cheah, Phaik Yeong, Peto, Thomas J, von Seidlein, Lorenz, Dhorda, Mehul, Maude, Richard J, Winterberg, Markus, Thuy-Nhien, Nguyen T, Kwiatkowski, Dominic P, Imwong, Mallika, Jittamala, Podjanee, Lin, Khin, Hlaing, Tin Maung, Chotivanich, Kesinee, Huy, Rekol, Fanello, Caterina, Ashley, Elizabeth, Mayxay, Mayfong, Newton, Paul N, Hien, Tran Tinh, Valeche, Neena, Smithuis, Frank, Pukrittayakamee, Sasithon, Faiz, Abul, Miotto, Olivo, Tarning, Joel, Day, Nicholas PJ, White, Nicholas J, Dondorp, Arjen M, Pyae Phyo, Aung, Thuy-Nhien, Nguyen Thanh, Valecha, Neena, and Day, Nicholas P J

Published
2020
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31. Diagnostic and antibiotic use practices among COVID-19 and non-COVID-19 patients in the Indonesian National Referral Hospital

Author

Sinto, Robert, primary, Lie, Khie Chen, additional, Setiati, Siti, additional, Suwarto, Suhendro, additional, Nelwan, Erni J., additional, Karyanti, Mulya Rahma, additional, Karuniawati, Anis, additional, Djumaryo, Dean Handimulya, additional, Prayitno, Ari, additional, Sumariyono, Sumariyono, additional, Sharland, Mike, additional, Moore, Catrin E., additional, Hamers, Raph L., additional, Day, Nicholas P. J., additional, and Limmathurotsakul, Direk, additional

Published
2024
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33. Clustering of malaria in households in the Greater Mekong Subregion: operational implications for reactive case detection

Author

Mukaka, Mavuto, Peerawaranun, Pimnara, Parker, Daniel M., Kajeechiwa, Ladda, Nosten, Francois H., Nguyen, Thuy-Nhien, Hien, Tran Tinh, Tripura, Rupam, Peto, Thomas J., Phommasone, Koukeo, Mayxay, Mayfong, Newton, Paul N., Imwong, Mallika, Day, Nicholas P. J., Dondorp, Arjen M., White, Nicholas J., and von Seidlein, Lorenz

Published
2021
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35. Scrub typhus in Indonesia: A cross-sectional analysis of archived fever studies samples.

Author

Saraswati, Kartika, Tanganuchitcharnchai, Ampai, Ongchaikupt, Sirada, Mukaka, Mavuto, Day, Nicholas P J, Baird, J Kevin, Antonjaya, Ungke, Myint, Khin S A, Dewi, Yora P, Yudhaputri, Frilasita A, Haryanto, Sotianingsih, Witari, N P Diah, and Blacksell, Stuart D

Subjects
TSUTSUGAMUSHI disease, CROSS-sectional method, ENZYME-linked immunosorbent assay, BACTERIAL diseases, BETA lactam antibiotics, FEVER
Abstract

Background Scrub typhus is an understudied vector-borne bacterial infection. Methods We tested archived fever samples for scrub typhus seropositivity to begin charting its geographic distribution in Indonesia. We analysed 1033 serum samples from three sites. IgM and IgG enzyme-linked immunosorbent assay (ELISA) against Orientia tsutsugamushi was performed using Karp, Kato, Gilliam, TA 716 antigens. To determine the cutoff in the absence of a presumed unexposed population and gold standard tests, we identified the visual inflection point, performed change point analysis, and used finite mixture models. Results The optical density cutoff values used for IgM and IgG were 0.49 and 0.13, respectively. Across all sites, IgM seropositivity was 4.6% (95% CI: 3.4 to 6.0%) while IgG seropositivity was 4.4% (95% CI: 3.3 to 5.8%). The overall seropositivity across sites was 8.8% (95% CI: 8.1 to 11.7%). The overall seropositivity for Jambi, Denpasar, Tabanan were 9.7% (95% CI: 7.0 to 13.3%), 8.0% (95% CI: 5.7 to 11.0%), 9.0% (95% CI: 6.1 to 13.0%), respectively. Conclusions We conclude that O. tsutsugamushi exposure in humans occurred at all sites analysed and could be the cause of illness in some cases. Though it was not the main cause of acute fever in these locations, it is still important to consider scrub typhus in cases not responding to beta-lactam antibiotics. Future seroprevalence surveys and testing for scrub typhus in acute febrile illness studies will be essential to understand its distribution and burden in Indonesia. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Understanding reticence to occupy free, novel-design homes: A qualitative study in Mtwara, Southeast Tanzania

Author

Meta, Judith, primary, Mshamu, Salum, additional, Halifa, Salma, additional, Mmbando, Arnold, additional, Wood, Hannah Sloan, additional, Wood, Otis Sloan, additional, Bøjstrup, Thomas Chevalier, additional, Day, Nicholas P. J., additional, Knudsen, Jakob, additional, Lindsay, Steven W., additional, Deen, Jacqueline, additional, von Seidlein, Lorenz, additional, and Pell, Christopher, additional

Published
2023
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38. Plasma Metabolomics Reveals Distinct Biological and Diagnostic Signatures for Melioidosis

Author

Xia, Lu, primary, Hantrakun, Viriya, additional, Teparrukkul, Prapit, additional, Wongsuvan, Gumphol, additional, Kaewarpai, Taniya, additional, Dulsuk, Adul, additional, Day, Nicholas P. J., additional, Lemaitre, Rozenn N, additional, Chantratita, Narisara, additional, Limmathurotsakul, Direk, additional, Shojaie, Ali, additional, Gharib, Sina A, additional, and West, T Eoin, additional

Published
2023
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39. Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria : A Randomized, Controlled, Open-Label Trial

Author

Plewes, Katherine, Kingston, Hugh W. F., Ghose, Aniruddha, Wattanakul, Thanaporn, Hassan, Md. Mahtab Uddin, Haider, Md. Shafiul, Dutta, Prodip K., Islam, Md. Akhterul, Alam, Shamsul, Jahangir, Selim Md., Zahed, A. S. M., Sattar, Md. Abdus, Chowdhury, M. A. Hassan, Herdman, M. Trent, Leopold, Stije J., Ishioka, Haruhiko, Piera, Kim A., Charunwatthana, Prakaykaew, Silamut, Kamolrat, Yeo, Tsin W., Lee, Sue J., Mukaka, Mavuto, Maude, Richard J., Turner, Gareth D. H., Faiz, Md. Abul, Tarning, Joel, Oates, John A., Anstey, Nicholas M., White, Nicholas J., Day, Nicholas P. J., Hossain, Md. Amir, Roberts, L. Jackson, and Dondorp, Arjen M.

Published
2018

42. Antiviral efficacy of molnupiravir versus ritonavir-boosted nirmatrelvir in patients with early symptomatic COVID-19 (PLATCOV): an open-label, phase 2, randomised, controlled, adaptive trial

Author

Schilling, William H K, primary, Jittamala, Podjanee, additional, Watson, James A, additional, Boyd, Simon, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Batty, Elizabeth M, additional, Cruz, Cintia, additional, Callery, James J, additional, Singh, Shivani, additional, Saroj, Manisaree, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tanglakmankhong, Nuttakan, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Madmanee, Wanassanan, additional, Kouhathong, Jindarat, additional, Suwannasin, Kanokon, additional, Pagornrat, Watcharee, additional, Piaraksa, Nattaporn, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Poovorawan, Kittiyod, additional, Potaporn, Manus, additional, Srisubat, Attasit, additional, Loharjun, Bootsakorn, additional, Taylor, Walter R J, additional, Chotivanich, Vasin, additional, Chotivanich, Kesinee, additional, Imwong, Mallika, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas P J, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, White, Nicholas J, additional, Schilling, William HK, additional, Day, Nicholas PJ, additional, Taylor, Walter RJ, additional, Thaipadungpanit, Janjira, additional, Ekkapongpisit, Maneerat, additional, Ruksakul, Wiroj, additional, Sangketchon, Chunlanee, additional, Sookprome, Sakol, additional, Teixeira, Mauro, additional, Almeida, Pedro J, additional, Aguiar, Renato S, additional, Santos, Franciele, additional, Ashley, Elizabeth, additional, Vongsouvath, Manivanh, additional, Phommasone, Koukeo, additional, Dubot-Pérès, Audrey, additional, Vidhamaly, Sisouphanh, additional, Chingsanoon, Ammala, additional, Bisayher, Sixiong, additional, Chommanam, Danoy, additional, Evans, Terry John, additional, Vidhamaly, Vayouly, additional, Boutthasavong, Latsaniphone, additional, and Mayxay, Mayfong, additional

Published
2023
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43. Clinical antiviral efficacy of remdesivir in COVID-19: an open label, randomized, controlled adaptive platform trial (PLATCOV)

Author

Jittamala, Podjanee, primary, Schilling, William H K, additional, Watson, James A, additional, Luvira, Viravarn, additional, Siripoon, Tanaya, additional, Ngamprasertchai, Thundon, additional, Almeida, Pedro J, additional, Ekkapongpisit, Maneerat, additional, Cruz, Cintia, additional, Callery, James J, additional, Boyd, Simon, additional, Anunsittichai, Orawan, additional, Hongsuwan, Maliwan, additional, Singhaboot, Yutatirat, additional, Pagornrat, Watcharee, additional, Tuntipaiboontana, Runch, additional, Kruabkontho, Varaporn, additional, Ngernseng, Thatsanun, additional, Tubprasert, Jaruwan, additional, Abdad, Mohammad Yazid, additional, Keayarsa, Srisuda, additional, Madmanee, Wanassanan, additional, Aguiar, Renato S, additional, Santos, Franciele M, additional, Batty, Elizabeth M, additional, Hanboonkunupakarn, Pongtorn, additional, Hanboonkunupakarn, Borimas, additional, Sookprome, Sakol, additional, Poovorawan, Kittiyod, additional, Imwong, Mallika, additional, Taylor, Walter R J, additional, Chotivanich, Vasin, additional, Sangketchon, Chunlanee, additional, Ruksakul, Wiroj, additional, Chotivanich, Kesinee, additional, Pukrittayakamee, Sasithon, additional, Dondorp, Arjen M, additional, Day, Nicholas P J, additional, Teixeira, Mauro M, additional, Piyaphanee, Watcharapong, additional, Phumratanaprapin, Weerapong, additional, and White, Nicholas J, additional

Published
2023
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46. Mapping the travel patterns of people with malaria in Bangladesh

Author

Sinha, Ipsita, Sayeed, Abdullah Abu, Uddin, Didar, Wesolowski, Amy, Zaman, Sazid Ibna, Faiz, M. Abul, Ghose, Aniruddha, Rahman, M. Ridwanur, Islam, Akramul, Karim, Mohammad Jahirul, Saha, Anjan, Rezwan, M. Kamar, Shamsuzzaman, Abul Khair Mohammad, Jhora, Sanya Tahmina, Aktaruzzaman, M. M., Chang, Hsiao-Han, Miotto, Olivo, Kwiatkowski, Dominic, Dondorp, Arjen M., Day, Nicholas P. J., Hossain, M. Amir, Buckee, Caroline, and Maude, Richard J.

Published
2020
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48. Correction to: The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Author

Phommasone, Koukeo, van Leth, Frank, Imwong, Mallika, Henriques, Gisela, Pongvongsa, Tiengkham, Adhikari, Bipin, Peto, Thomas J., Promnarate, Cholrawee, Dhorda, Mehul, Sirithiranont, Pasathorn, Mukaka, Mavuto, Peerawaranun, Pimnara, Day, Nicholas P. J., Cobelens, Frank, Dondorp, Arjen M., Newton, Paul N., White, Nicholas J., von Seidlein, Lorenz, and Mayxay, Mayfong

Published
2020
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50. The use of ultrasensitive quantitative-PCR to assess the impact of primaquine on asymptomatic relapse of Plasmodium vivax infections: a randomized, controlled trial in Lao PDR

Author

Phommasone, Koukeo, van Leth, Frank, Imwong, Mallika, Henriques, Gisela, Pongvongsa, Tiengkham, Adhikari, Bipin, Peto, Thomas J., Promnarate, Cholrawee, Dhorda, Mehul, Sirithiranont, Pasathorn, Mukaka, Mavuto, Peerawaranun, Pimnara, Day, Nicholas P. J., Cobelens, Frank, Dondorp, Arjen M., Newton, Paul N., White, Nicholas J., von Seidlein, Lorenz, and Mayxay, Mayfong

Published
2020
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