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1. Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials?

Author

Di Cataldo, A., Agodi, A., Balaguer, J., Garaventa, A., Barchitta, M., Segura, V., Bianchi, M., Castel, V., Castellano, A., Cesaro, S., Couselo, J. M., Cruz, O., D’Angelo, P., De Bernardi, B., Donat, J., de Andoin, N. G., Hernandez, M. I., La Spina, M., Lillo, M., Lopez-Almaraz, R., Luksch, R., Mastrangelo, S., Mateos, E., Molina, J., Moscheo, C., Mura, R., Porta, F., Russo, G., Tondo, A., Torrent, M., Vetrella, S., Villegas, J. A., Viscardi, E., Zanazzo, G. A., and Cañete, A.

Published
2017
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2. Rawls, Hume, and Original Contract

Author

Maria Luisa Garrè, G. Stella, Riccardo Haupt, A. Ferrando, Comelli A, Vitali Ml, B. Cesana, P. Picco, De Bernardi B, and Gandus S

Subjects
Pediatrics, medicine.medical_specialty, business.industry, Cancer, Sequela, Disease, Malignancy, medicine.disease, Asymptomatic, Discontinuation, 03 medical and health sciences, 0302 clinical medicine, El Niño, 030220 oncology & carcinogenesis, medicine, medicine.symptom, business, 030215 immunology, Subclinical infection
Abstract

Purpose This study aims at defining the frequency and severity of late effects in a series of 288 long-term survivors of childhood cancer treated from 1962 to 1982 at the Giannina Gaslini Children's Research Hospital of Genoa, Italy. Patients and methods All cases with a diagnosis of malignancy in childhood and a minimum of 2.5 years from discontinuation of treatment were considered eligible. For all cases the study included physical, endocrinological, and psychological examination. Groups of patients selected according to treatment underwent cardiac, pulmonary, orthopedic, and ophthalmologic evaluation. The sequelae observed were scored according to a grading system in which asymptomatic subclinical defects are distinguished from those that are sufficiently symptomatic to require some type of corrective measure. Results Overall, 200 of 288 cases (69.4%) presented with some kind of abnormality. Symptomatic changes were present in 92 cases (42%); in these, severe and life-threatening late toxicity was reported in 61 (21.2%) and 12 cases (4.2%), respectively. The major risk factors appeared to be irradiation, type of tumor, and whether the patient had received therapy before 1974. Conclusions In our experience, this study demonstrates that there was a true excess of morbidity caused by the disease and its treatment in long-term survivors from almost any kind of childhood cancer. It also sheds light on how to prevent, diagnose, and adequately treat these patients and proposes specific criteria for the evaluation of the severity of delayed toxicity in long-term survivors of cancer in childhood.

Published
2020

3. Treatment of Poor-Risk Neuroblastoma with Intensive Chemotherapy and Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

Author

Lanino, E., Parasole, R., Garaventa, A., Arrighini, A., Bagnulo, S., Carli, M., Comis, S., di Montezemolo, L. Cordero, Di Tullio, M. T., Massolo, F., Mazzanti, P., Paolucci, P., Pasino, M., Boni, L., Tamaro, P., De Bernardi, B., Freund, Mathias, editor, Link, Hartmut, editor, Schmidt, Reinhold E., editor, and Welte, Karl, editor

Published
1992
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4. Age Dependency of the Prognostic Impact of Tumor Genomics in Localized Resectable MYCN -Nonamplified Neuroblastomas. Report From the SIOPEN Biology Group on the LNESG Trials and a COG Validation Group

Author

Ambros IM, Tonini GP, Pötschger U, Gross N, Mosseri V, Beiske K, Berbegall AP, Bénard J, Bown N, Caron H, Combaret V, Couturier J, Defferrari R, Delattre O, Jeison M, Kogner P, Lunec J, Marques B, Martinsson T, Mazzocco K, Noguera R, Schleiermacher G, Valent A, Van Roy N, Villamon E, Janousek D, Pribill I, Glogova E, Attiyeh EF, Hogarty MD, Monclair TF, Holmes K, Valteau-Couanet D, Castel V, Tweddle DA, Park JR, Cohn S, Ladenstein R, Beck-Popovic M, De Bernardi B, Michon J, Pearson ADJ, and Ambros PF

Subjects
neoplasms
Abstract

For localized, resectable neuroblastoma without MYCN amplification, surgery only is recommended even if incomplete. However, it is not known whether the genomic background of these tumors may influence outcome.

Published
2020

9. Quality Assessment of Genetic Markers Used for Therapy Stratification

Author

Ambros, I.M., Benard, J., Boavida, M., Bown, N., Caron, H., Combaret, V., Couturier, J., Darnfors, C., Delattre, O., Freeman-Edward, J., Gambini, C., Gross, N., Hattinger, C.M., Luegmayr, A., Lunec, J., Martinsson, T., Mazzocco, K., Navarro, S., Noguera, R., O’Neill, S., Pötschger, U., Rumpler, S., Speleman, F., Tonini, G.P., Valent, A., Van Roy, N., Amann, G., De Bernardi, B., Kogner, P., Ladenstein, R., Michon, J., Pearson, A.D.J., and Ambros, P.F.

Published
2003

12. Age-dependency of the prognostic impact of tumor genomics in localized resectable MYCN non-amplified neuroblastomas Report from the SIOPEN Biology Group on the LNESG Trials

Author

Ambros, I.M., Tonini, G.P., Gross, N., Mosseri, V., Pötschger, U., Beiske, K., Berbegall, A.P., Bénard, J., Bown, N., Caron, H., Combaret, V., Couturier, J., Defferrari, R., Delattre, O., Jeison, M., Kogner, P., Lunec, J., Marques, B., Martinsson, T., Mazzocco, K., Noguera, R., Schleiermacher, G., Valent, A., Van Roy, N., Villamon, E., Janousek, D., Pribill, I., Glogova, E., Attiyeh, E.F., Hogarty, M.D., Monclair, T., Holmes, K., Valteau-Couanet, D., Pearson ADJ, A.D.J., Castel, V., Tweddle, D.A., Park, J.R., Cohn, S., Ladenstein, R., Beck-Popovic, M., De Bernardi, B., Michon, J., and Ambros, P.F.

Subjects
Neuroblastoma, Tumor Genomics, MYCN, Doenças Genéticas
Abstract

BACKGROUND: Biology based treatment reduction, i.e. surgery alone also in case of not totally resected tumors, was advised in neuroblastoma patients with localized resectable disease without MYCN amplification. However, whether the genomic background of these tumors may influence outcome was unknown and therefore scrutinized in a meta-analysis comprising two prospective therapy studies and a ‘validation’ cohort. PATIENTS AND METHODS: Diagnostic samples were derived from 406 INSS stages 1/2A/2B tumors from three cohorts: LNESGI/II and COG. Genomic data were analyzed in two age groups (cut-off: 18 months) and quality controlled by the SIOPEN Biology Group. RESULTS: In both patient age groups stage 2 tumors led to similarly reduced event-free survival (5y-EFS: 83+3% versus 80+4%), but overall survival was only decreased in patients >18m (5y-OS: 97+1% versus 87+4%; p=0.001). In the latter age subgroup, only tumors with SCA led to relapses, with 11q loss as the strongest marker (5y-EFS: 40+15% versus 89+5%; p18m but not

Published
2018

14. Age-dependent Prognostic Significance of N-myc Copy Number in Neuroblastoma1

Author

Tonini, G. P., primary, Badiali, M., additional, Cavazzana, A., additional, Di Martino, D., additional, Dominici, C., additional, Fontana, V., additional, Iolascon, A., additional, Lanino, E., additional, Basso, G., additional, Pession, A., additional, Raschellá, G., additional, Strigini, P., additional, Sansone, R., additional, and De Bernardi, B., additional

Published
1990
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15. Soft Tissue Sarcomas in Infants Less than 1 Year Old: Experience of the Italian Cooperative Study RMS-791

Author

Carli, M., primary, Grotto, P., additional, Perilongo, G., additional, di Montezemolo, L. Cordero, additional, Cecchetto, G., additional, De Bernardi, B., additional, Deb, G., additional, Di Tullio, M. T., additional, Bagnulo, S., additional, LoCurto, M., additional, Mancini, A., additional, Andrello, L., additional, Sotti, G., additional, and Masarotto, G., additional

Published
1990
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16. ROLE OF SURGERY IN NEUROBLASTOMA 4S : A CRITICAL UPDATE

Author

Paraboschi, Irene, De Bernardi, B., Conte, M., Garaventa, A., Cecchetto, G., Inserra, A., Riccipetitoni, G., Mattioli, Girolamo, Leonelli, Lorenzo, Massirio, Paolo, Pio, Luca, Haupt, R., Pistorio, A., Avanzini, S., and Martucciello, Giuseppe

Subjects
NEUROBLASTOMA 4S
Published
2017

20. Carcinoid syndrome

Author

Granata, C., Haupt, R., Mazzaferro, V., Fratino, G., Mattioli, G., Gasparini, M., and De Bernardi, B.

Published
1996
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21. Metastatic neuroblastoma in infants: are survival rates excellent only within the stringent framework of clinical trials?

Author

Di Cataldo, A., primary, Agodi, A., additional, Balaguer, J., additional, Garaventa, A., additional, Barchitta, M., additional, Segura, V., additional, Bianchi, M., additional, Castel, V., additional, Castellano, A., additional, Cesaro, S., additional, Couselo, J. M., additional, Cruz, O., additional, D’Angelo, P., additional, De Bernardi, B., additional, Donat, J., additional, de Andoin, N. G., additional, Hernandez, M. I., additional, La Spina, M., additional, Lillo, M., additional, Lopez-Almaraz, R., additional, Luksch, R., additional, Mastrangelo, S., additional, Mateos, E., additional, Molina, J., additional, Moscheo, C., additional, Mura, R., additional, Porta, F., additional, Russo, G., additional, Tondo, A., additional, Torrent, M., additional, Vetrella, S., additional, Villegas, J. A., additional, Viscardi, E., additional, Zanazzo, G. A., additional, and Cañete, A., additional

Published
2016
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23. TUMORI A CELLULE GERMINALI MALIGNI IN ETA’ PEDIATRICA: RISULTATI DEL II STUDIO COOPERATIVO ITALIANO TCG 98

Author

Dall'Igna, P., LO CURTO, M., Fiori, G., Alaggio, R., Cesca, E., Basso, E., Siracusa, F., De Bernardi, B., Tamaro, P., Boglino, C., Cecchetto, G., Dall'Igna, P., LO CURTO, M., Fiori, G., Alaggio, R., Cesca, E., Basso, E., Siracusa, F., De Bernardi, B., Tamaro, P., Boglino, C., and Cecchetto, G.

Subjects
protocollo italiano TCG 98, Settore MED/38 - Pediatria Generale E Specialistica, Tumori in età pediatrica, tumori a cellule germinali, tumori a cellule germinali maligni, Settore MED/20 - Chirurgia Pediatrica E Infantile
Abstract

Gli Autori presentano i risultati del Secondo Studio Cooperativo Italiano sui Tumori a Cellulle Germinali Maligni del bambino, esito del Proytocollo Nazionale TCG 98.

Published
2004

28. Segmental chromosomal alterations lead to a higher risk of relapse in infants with MYCN-non-amplified localised unresectable/disseminated neuroblastoma (a SIOPEN collaborative study). . 105:1940-1948,2011

Author

Schleiermacher, G, Michon, J, Ribeiro, A, Pierron, G, Mosseri, V, Rubie, H, Munzer, C, Bénard, J, Auger, N, Combaret, V, Janoueix Lerosey, I, Pearson, A, Tweddle, Da, Bown, N, Gerrard, M, Wheeler, K, Noguera, R, Villamon, E, Cañete, A, Castel, V, Marques, B, de Lacerda, A, Tonini, Gp, Mazzocco, K, Defferrari, R, de Bernardi, B, DI CATALDO, Andrea, van Roy, N, Brichard, B, Ladenstein, R, Ambros, I, Ambros, P, Beiske, K, Delattre, O, and Couturier, J.

Subjects
neuroblastoma, infants, genomic profile, segmental chromosome alterations, prognosis
Published
2011

33. Calcareous phytoplankton response to the half century of interannual climatic variability in Santa Barbara Basin (California)

Author

De Bernardi, B., Ziveri, P., Erba, E., Thunell, R.C., and Marine Biogeology

Subjects
Santa Barbara Basin, Decadal ocean variability, Settore GEO/01 - Paleontologia e Paleoecologia, Anoxic environments, Phytoplankton, Coccolithophores, SDG 14 - Life Below Water, Climate variability
Abstract

A high-resolution study of calcareous phytoplankton in a box core from the Santa Barbara Basin (SBB) reveals floral assemblage fluctuations which can be related to climatic and paleoceanographic changes during the last half century (1940-1996). In particular, Gephyrocapsa oceanica production increased during El Niño periods, in response to high temperatures, silica depletion, and increased iron availability. Conversely, Helicosphaera carteri flux increases in conjunction with lower surface temperatures associated with La Niña episodes. Increasing abundances of Florisphaera profunda and Umbilicosphaera sibogae after 1970 reflect a warming trend and increased stratification within the basin associated with the warm phase of the Pacific Decadal Oscillation (PDO). Conversely, increased abundances of Coccolithus pelagicus and Calcidiscus leptoporus before 1970 mark the cold phase of PDO. These coccolithophore production rate data are consistent with instrumental records of surface and thermocline temperatures monitored since 1950. This is the first study to document the response of calcareous phytoplankton to surface water warming occurring in SBB since 1970. Copyright 2008 by the American Geophysical Union.

Published
2008

44. Ganglioneuroma: 146 casi del registro italiano neuroblastoma

Author

DE BERNARDI, B, Haupt, R, Conte, M, Bianchi, M, Arcamone, P, Castellano, A, Dangelo, P, DI CATALDO, Andrea, Giuliano, M, Prete, A, Provenzi, M, Tamburini, A, Tettoni, K, Viscardi, E, Zanazzo, G, and Angelini, P.

Published
2007

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