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1. Chemical Composition of Essential Oils from Eight Tunisian Eucalyptus Species and Their Antifungal and Herbicidal Activities.

Author

Ayed, Amira, Polito, Flavio, Mighri, Hedi, Souihi, Mouna, Caputo, Lucia, Hamrouni, Lamia, Amri, Ismail, Nazzaro, Filomena, De Feo, Vincenzo, Hirsch, Ann, and Mabrouk, Yassine

Subjects
Eucalyptus, antifungal activity, essential oils, herbicidal activity
Abstract

Eucalyptus species are known to produce metabolites such as essential oils (EOs) that play an important role in the control of weeds, pests and phytopathogenic fungi. The aims of this study were as follows: (i) to determine the chemical composition of the EOs derived from eight Eucalyptus species growing in Tunisia, and (ii) to study their possible antifungal and herbicidal activities. EOs were obtained by hydrodistillation from the dried leaves of eight Eucalyptus species, namely, E. angulosa, E. cladocalyx, E. diversicolor, E. microcoryx, E. ovata, E. resinifera, E. saligna and E. sargentii, and the determination of their composition was achieved by GC and GC-MS. The EOs antifungal activities were tested against four Fusarium strains, and the EOs herbicidal properties were evaluated on the germination and seedling growth of three annual weeds (Trifolium campestre, Lolium rigidum and Sinapis arvensis) and three cultivated crop species (Lepidium sativum, Raphanus sativus and Triticum durum). The EO yields ranged between 0.12 and 1.32%. The most abundant components found were eucalyptol, α-pinene, p-cymene, trans-pinocarveol, α-terpineol and globulol. All EOs showed significant antifungal activity against the four phytopathogenic Fusarium strains. E. cladocalyx EO exhibited the highest level of antifungal activity, and the greatest inhibition of seed germination was obtained even at lowest concentrations used. These findings suggested that E. resinifera, E. ovata and E. cladocalyx EOs could have applications in agriculture as possible biopesticides, as Fusarium antagonists and as bioherbicides.

Published
2023

11. Investigating the eco-friendly extracts of Salvia pratensis L. for sustainable agricultural applications

Author

Grulova, Daniela, primary, Baranová, Beata, additional, Eliašová, Adriana, additional, Brun, Christelle, additional, De Martino, Laura, additional, Caputo, Lucia, additional, Poračová, Janka, additional, Nastišin, Ľuboš, additional, Fejér, Jozef, additional, Elshafie, Hazem, additional, De Feo, Vincenzo, additional, and Končná, Mária, additional

Published
2024
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12. Chemical Composition and Phytotoxic and Antibiofilm Activity of the Essential Oils of two Moroccan Retama species

Author

Benrazzouk, Karima, primary, Ouhaddou, Soukaina, additional, Nazzaro, Filomena, additional, Fratianni, Florinda, additional, Bekkouche, Khalid, additional, De Tommasi, Nunziatina, additional, Markouk, Mohammed, additional, Larhsini, Mustapha, additional, Caputo, Lucia, additional, De Feo, Vincenzo, additional, and Polito, Flavio, additional

Published
2024
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24. Contributors

Author

Aguilar, Cristóbal N., primary, Aires, Alfredo, additional, Al Daccache, Marina, additional, Albarelli, Juliana Q., additional, Alexandre, Elisabete Maria da Cruz, additional, Barros, Lillian, additional, Bichara, Carissa Michelle Goltara, additional, Borrás-Linares, Isabel, additional, Chañi-Paucar, Larry Oscar, additional, Chemat, Farid, additional, Coppola, Raffaele, additional, Costa, Eduardo M., additional, Cruz, Adriano G., additional, da Silva Martins, Luiza Helena, additional, De Feo, Vincenzo, additional, de Freitas, Victor, additional, de Oliveira, Johnatt Allan Rocha, additional, del Castillo-Santaella, Teresa, additional, Dias, Maria Inês, additional, Dimitrov, Krasimir, additional, Emanuelli, Tatiana, additional, Fabiano-Tixier, Anne-Sylvie, additional, Fernandes, Ana, additional, Ferreira, Isabel C.F.R., additional, Ferreira-Santos, Pedro, additional, Fratianni, Florinda, additional, Genisheva, Zlatina, additional, Komesu, Andrea, additional, Koubaa, Mohamed, additional, Liberal, Ângela, additional, López-Salas, Lucía, additional, Louka, Nicolas, additional, Lozano-Sánchez, Jesús, additional, Maroun, Richard G., additional, Mateus, Nuno, additional, Meireles, Maria Angela A., additional, Molina, Adriana K., additional, Moreira, Debora Kono Taketa, additional, Moreira, Silvia A., additional, Nazzaro, Filomena, additional, Oliveira, Ana L.S., additional, Oliveira, Hélder, additional, Paz-Arteaga, Sarah L., additional, Pereira, Carla, additional, Pereira, Ricardo N., additional, Pimentel, Tatiana Colombo, additional, Pintado, Manuela Estevez, additional, Pinto, Carlos A., additional, Pradal, Delphine, additional, Rai, Mahendra, additional, Rajha, Hiba N., additional, Ramírez-Guzmán, Nathiely, additional, Rocha, Cristina M.R., additional, Rodrigues, Rui M., additional, Santana, Ádina L., additional, Saraiva, Jorge Manuel Alexandre, additional, Segura-Carretero, Antonio, additional, Serna-Cock, Liliana, additional, Silva, Sara, additional, Teixeira, Natércia, additional, Torres-León, Cristian, additional, Vauchel, Peggy, additional, Vicente, António A., additional, Vorobiev, Eugène, additional, and Voss, Glenise Bierhalz, additional

Published
2022
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25. Artemisia spp. Essential Oils: From Their Ethnobotanical Use to Unraveling the Microbiota Modulation Potential

Author

Polito, Flavio, Di Mercurio, Mattia, Rizzo, Silvia, Di Vito, Maura, Sanguinetti, Maurizio, Urbani, Andrea, Bugli, Francesca, De Feo, Vincenzo, Di Vito, Maura (ORCID:0000-0002-2991-0855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Urbani, Andrea (ORCID:0000-0001-9168-3174), Bugli, Francesca (ORCID:0000-0001-9038-3233), Polito, Flavio, Di Mercurio, Mattia, Rizzo, Silvia, Di Vito, Maura, Sanguinetti, Maurizio, Urbani, Andrea, Bugli, Francesca, De Feo, Vincenzo, Di Vito, Maura (ORCID:0000-0002-2991-0855), Sanguinetti, Maurizio (ORCID:0000-0002-9780-7059), Urbani, Andrea (ORCID:0000-0001-9168-3174), and Bugli, Francesca (ORCID:0000-0001-9038-3233)

Abstract

Background: The 2015 Nobel Prize in Medicine, awarded for the discovery of artemisinin in Artemisia annua, reignited interest in aromatic plants, including Artemisia absinthium L. This article delves into the historical, ethnopharmacological and medicinal significance of A. absinthium, examining its bitter taste noted since ancient Greek times and its association with medicinal properties throughout history. Despite being banned in the 20th century due to perceived health risks; recent research has led to the reconsideration of A. absinthium's potential applications. This study focuses on the prebiotic efficacy of essential oils (EOs) from two Artemisia species: A. absinthium and A. annua. Materials and methods: A broth microdilution test, growth curve test and in vivo models were used to study the impact of low doses (from 0.5% v/v to 0.00048 v/v) of Artemisia spp-EO on the three probiotic strains (Lactobacillus, Lactobacillus casei and Saccharomyces boulardii). Results: These essential oils, when used in minimal concentrations (lower than 0.06% v/v), are safe and exhibit prebiotic effects on major probiotic strains, supporting the traditional culinary use of Artemisia spp. Conclusion: This research opens avenues for potential applications in the food industry, emphasizing the need for further exploration into the prebiotic properties of Artemisia spp-EOs and their influence on the microbiota.

Published
2024

29. Pulicaria incisa (Lam.) DC. as a Potential Source of Antioxidant, Antibacterial, and Anti-Enzymatic Bioactive Molecules: Phytochemical Constituents, In Vitro and In Silico Pharmacological Analysis

Author

Alreshidi, Mousa, primary, Abdulhakeem, Mohammad A., additional, Badraoui, Riadh, additional, Amato, Giuseppe, additional, Caputo, Lucia, additional, De Martino, Laura, additional, Nazzaro, Filomena, additional, Fratianni, Florinda, additional, Formisano, Carmen, additional, De Feo, Vincenzo, additional, and Snoussi, Mejdi, additional

Published
2023
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31. Chemical composition, phytotoxic and antibiofilm activity of Pinus canariensis, P. jeffreyi and P. taeda essential oils.

Author

Khedhri, Sana, Polito, Flavio, Caputo, Lucia, Khamassi, Marwa, Hamrouni, Lamia, Nazzaro, Filomena, Fratianni, Florinda, Scognamiglio, Maria Rosa, De Feo, Vincenzo, and Amri, Ismail

Subjects
ESSENTIAL oils, PINE, GRAM-negative bacteria, PATHOGENIC bacteria, LISTERIA monocytogenes, ACINETOBACTER baumannii, PSEUDOMONAS aeruginosa, PINACEAE
Abstract

This study aimed to investigate the chemical composition and some biological activities of the essential oils (EOs) from needles of Pinus canariensis, P. jeffreyi, and P. taeda cultivated in Tunisia. The chemical composition of the EOs revealed the presence of 119 components, with monoterpene hydrocarbons (in EOs of P. canariensis and P. taeda) and sesquiterpene hydrocarbons (in P. jeffreyi EO) being the main chemical classes. The EOs showed significant inhibitory effects on the germination and seedling and radical growth of the weeds, Sinapis arvensis, Lolium rigidum, and Trifolium campestre. The EO of P. jeffreyi exhibited the highest phytotoxicity, while T. campestre was the most tolerant seed. The EOs showed antibiofilm activity against Gram-positive (Staphylococcus aureus and Listeria monocytogenes) and Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli) pathogenic bacterial strains, depending on the EO, and the concentration tested. Overall, the EOs displayed efficacy against mature biofilms and were effective also against the metabolism of the sessile cells in the biofilm. These findings provide valuable insights into the potential applications of these EOs in phytotoxic and antibiofilm strategies, for agriculture, food and pharmaceutical fields. [ABSTRACT FROM AUTHOR]

Published
2024
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32. Chemical Characterization and Biological Properties of Leguminous Honey.

Author

Fratianni, Florinda, Amato, Giuseppe, Ombra, Maria Neve, De Feo, Vincenzo, Nazzaro, Filomena, and De Giulio, Beatrice

Subjects
PHENOL oxidase, ANTIOXIDANTS, HONEY, VOLATILE organic compounds, SINGLE molecules, BUTYRYLCHOLINESTERASE, VITAMIN C
Abstract

Honey can beneficially act against different human diseases, helping our body to improve its health. The aim of the present study was first to increase knowledge of some biochemical characteristics (amount and composition of polyphenols and volatile organic compounds, vitamin C content) of five Italian legume honeys (alfalfa, astragalus, carob, indigo, and sainfoin). Furthermore, we evaluated their potential health properties by studying their antioxidant and in vitro anti-inflammatory activities and in vitro inhibitory effects on three enzymes involved in neurodegenerative diseases (acetylcholinesterase, butyrylcholinesterase, and tyrosinase). Alfalfa honey showed the highest total polyphenol content (TPC) (408 μg g−1 of product). Indigo honey showed the lowest TPC (110 μg g−1 of product). The antioxidant activity was noteworthy, especially in the case of sainfoin honey (IC50 = 6.08 mg), which also exhibited excellent inhibitory action against butyrylcholinesterase (74%). Finally, the correlation between the biochemical and functional results allowed us to identify classes of molecules, or even single molecules, present in these five honeys, which are capable of influencing the properties indicated above. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Essential Oils and Microbial Communication

Author

Nazzaro, Filomena, primary, Fratianni, Florinda, additional, d’Acierno, Antonio, additional, Coppola, Raffaele, additional, Jesus Ayala-Zavala, Fernando, additional, Gomez da Cruz, Adriano, additional, and De Feo, Vincenzo, additional

Published
2020
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40. Contributors

Author

Abete, Itziar, primary, Aboussaleh, Youssef, additional, Accardi, Giulia, additional, Aiello, Anna, additional, Alkhatib, Ahmad, additional, Alves Castro, Inar, additional, Andújar, Isabel, additional, Antonopoulou, Smaragdi, additional, Arsic, Aleksandra, additional, Arvanitidou, Eirini-Iro, additional, Assaf-Balut, Carla, additional, Barabash, Ana, additional, Barbagallo, Mario, additional, Bastida, Sara, additional, Beccari, Giovanni, additional, Benedí, Juana, additional, Bentrad, Najla, additional, Bernal-Lopez, M. Rosa, additional, Bonaccio, Marialaura, additional, Bonanni, Americo, additional, Bordiú, Elena, additional, Bottalico, Francesco, additional, Boutopoulou, Barbara, additional, Buscemi, Silvio, additional, Calle-Pascual, Alfonso Luis, additional, Cámara, Montaña, additional, Candore, Giuseppina, additional, Capone, Roberto, additional, Caputo, Marina, additional, Cardone, Gianluigi, additional, Caruso, Calogero, additional, Caso, Giulia, additional, Castro-Quezada, Itandehui, additional, Cebadera-Miranda, Laura, additional, Cerezo, Ana B., additional, Corleo, Davide, additional, Corrêa, Rúbia C.G., additional, Covarelli, Lorenzo, additional, Czarczyńska-Goślińska, Beata, additional, Davinelli, Sergio, additional, del Valle, Laura, additional, Delgado-Andrade, Cristina, additional, Demetriou, Christiana A., additional, Detopoulou, Paraskevi, additional, Di Gioia, Francesco, additional, Diamantopoulos, E.J., additional, Dominguez, Ligia J., additional, Donati, Maria Benedetta, additional, Douros, Konstantinos, additional, Durán, Alejandra, additional, El Bilali, Hamid, additional, El Kinany, Khaoula, additional, El Rhazi, Karima, additional, Ergoren, Mahmut Cerkez, additional, De Feo, Vincenzo, additional, Ferreira, Isabel C.F.R., additional, Formica, Melissa, additional, Fragopoulou, Elizabeth, additional, Fratianni, Florinda, additional, de Gaetano, Giovanni, additional, Gaforio, José J., additional, Galarregui, Cristina, additional, Gallardo-Escribano, Cristina, additional, Galozzi, Paola, additional, Galvano, Fabio, additional, Garces-Martin, Maria, additional, Garcia-Larsen, Vanessa, additional, Garcia-Parrilla, M. Carmen, additional, Garcimartín, Alba, additional, Geliebter, Jan, additional, George, Elena S., additional, Georgousopoulou, Ekavi N., additional, Gesteiro, E., additional, Gkiouras, Konstantinos, additional, Gómez-Pérez, Ana María, additional, Goulis, Dimitrios G., additional, Gouveri, E., additional, Grammatikopoulou, Maria G., additional, Hadjisavvas, Andreas, additional, Hamida-Ferhat, Asma, additional, Hardman, Roy J., additional, Hornedo-Ortega, Ruth, additional, Iacoviello, Licia, additional, Iriti, Marcello, additional, Jeszka-Skowron, Magdalena, additional, Kakkoura, Maria G., additional, Karras, Spyridon N., additional, Knox, E., additional, Kotsa, Kalliopi, additional, Koufakis, Theocharis, additional, Koumpagioti, Despina, additional, Kyriacou, Kyriacos, additional, de la Torre, Nuria García, additional, Lampropoulou, Maria, additional, Loizidou, Maria A., additional, De Lorenzo, Antonino, additional, Macho-González, Adrián, additional, Magriplis, Emmanuella, additional, Marakomichelakis, G., additional, Martínez, J. Alfredo, additional, De Martino, Laura, additional, Medina, F. Xavier, additional, Mellor, Duane D., additional, Menotti, Alessandro, additional, Mesías, Marta, additional, Molina-Vega, María, additional, Morales, Patricia, additional, Moreno, Juan A., additional, Muros, J.J., additional, Nazzaro, Filomena, additional, Nomikos, Tzortzis, additional, Oliviero, Francesca, additional, Ottomano Palmisano, Giovanni, additional, de Pablos, Rocío M., additional, Panagiotakos, Demosthenes B., additional, Papandreou, Christopher, additional, Petropoulos, Spyridon A., additional, Prodam, Flavia, additional, Puddu, Paolo Emilio, additional, Punzi, Leonardo, additional, Quiles, José L., additional, Ramirez-Perez, Cristina, additional, Ramirez-Tortosa, Cesar L., additional, Ramírez-Tortosa, MCarmen, additional, Richard, Tristan, additional, Ricotti, Roberta, additional, Ríos, José-Luis, additional, Rodríguez-García, Carmen, additional, Román-Viñas, Blanca, additional, Ros, Emilio, additional, Rubio, Miguel Angel, additional, Ruiz-Moreno, M. Isabel, additional, Sacerdote, Carlotta, additional, Salas-Salvadó, Jordi, additional, Sánchez-Muniz, Francisco J., additional, Sánchez-Quesada, Cristina, additional, Scapagnini, Giovanni, additional, Scolaro, Bianca, additional, Seiquer, Isabel, additional, Serra-Majem, Lluís, additional, Sfriso, Paolo, additional, Spinella, Paolo, additional, Theodoridis, Xenophon, additional, Tinahones, Francisco J., additional, Tini, Francesco, additional, Tiwari, Raj, additional, Tranidou, Antigoni, additional, Troncoso, Ana M., additional, Tsofliou, Fotini, additional, Tuncel, Gulten, additional, Valerio, Johanna, additional, Varoni, Elena Maria, additional, Vilches-Perez, Alberto, additional, Vineis, Paolo, additional, Vitalini, Sara, additional, Zalvan, Craig H., additional, Zampelas, Antonis, additional, Zebekakis, Pantelis, additional, and Zulet, M. Angeles, additional

Published
2020
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42. GC/MS Profiling, Antibacterial, Anti-Quorum Sensing, and Antibiofilm Properties of Anethum graveolens L. Essential Oil: Molecular Docking Study and In-Silico ADME Profiling

Author

Noumi, Emira, primary, Ahmad, Iqrar, additional, Adnan, Mohd, additional, Merghni, Abderrahmen, additional, Patel, Harun, additional, Haddaji, Najla, additional, Bouali, Nouha, additional, Alabbosh, Khulood Fahad, additional, Ghannay, Siwar, additional, Aouadi, Kaïss, additional, Kadri, Adel, additional, Polito, Flavio, additional, Snoussi, Mejdi, additional, and De Feo, Vincenzo, additional

Published
2023
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44. Chemical composition, phytotoxic and antibiofilm activity of Pinus canariensis, P. jeffreyiand P. taedaessential oils

Author

Khedhri, Sana, Polito, Flavio, Caputo, Lucia, Khamassi, Marwa, Hamrouni, Lamia, Nazzaro, Filomena, Fratianni, Florinda, Scognamiglio, Maria Rosa, De Feo, Vincenzo, and Amri, Ismail

Abstract

AbstractThis study aimed to investigate the chemical composition and some biological activities of the essential oils (EOs) from needles of Pinus canariensis, P. jeffreyi, and P. taedacultivated in Tunisia. The chemical composition of the EOs revealed the presence of 119 components, with monoterpene hydrocarbons (in EOs of P. canariensisand P. taeda) and sesquiterpene hydrocarbons (in P. jeffreyiEO) being the main chemical classes. The EOs showed significant inhibitory effects on the germination and seedling and radical growth of the weeds, Sinapis arvensis, Lolium rigidum, and Trifolium campestre. The EO of P. jeffreyiexhibited the highest phytotoxicity, while T. campestrewas the most tolerant seed. The EOs showed antibiofilm activity against Gram-positive (Staphylococcus aureusand Listeria monocytogenes) and Gram-negative (Acinetobacter baumannii, Pseudomonas aeruginosa, and Escherichia coli) pathogenic bacterial strains, depending on the EO, and the concentration tested. Overall, the EOs displayed efficacy against mature biofilms and were effective also against the metabolism of the sessile cells in the biofilm. These findings provide valuable insights into the potential applications of these EOs in phytotoxic and antibiofilm strategies, for agriculture, food and pharmaceutical fields.

Published
2024
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45. Essential oils from Anethum graveolensL. and their phytotoxic and antibiofilm potential

Author

Polito, Flavio, Khammassi, Marwa, Kouki, Habiba, Amri, Ismail, Di Vito, Maura, Urbani, Andrea, Nazzaro, Filomena, Fratianni, Florinda, and De Feo, Vincenzo

Abstract

AbstractEssential oils (EOs) from inflorescences (EO-i), stems (EO-s) and leaves (EO-l) of Anethum graveolensare analyzed by GC and GC-MS. The main components are α-phellandrene (51.44%) and p-cymene (22.65%) in the EO-i, p-cymene (50.75%) and α-phellandrene (35.73%) in EO-s and p-cymene (40.01%) and α-phellandrene (36.38%) in EO-l. The phytotoxic activity was tested against germination and growth of aerial parts and roots of dicotyledones (Sinapis arvensisand Trifolium campestre) and monocotyledone (Lolium multiflorum) weeds. The EOs proved to be particularly active against S. arvensisand T. campestre, causing total inhibition of germination and growth at the highest doses (2.0 and 1.5 μL/mL) with IC50values included between 0.3 and 1.6 mg/mL. The antibacterial and antibiofilm activity was tested against Gram positive (Staphylococcus aureussubsp. aureusand Listeria monocytogenes) and Gram negative (Acinetobacter baumannii, Pseudomonas aeruginosaand Escherichia coli) pathogenic bacterial strains. EOs presented MICs lower than those of Tetracycline (20-24 mg/mL) against most bacterial strains (from 4 to 6 mg/mL). EOs were found to be active in inhibiting bacterial biofilm formation with IC50values between 1.47 and 3.85 mg/mL. The activity against bacterial metabolism occurred for EO-i and EO-s against A. baumanniiand E. coliwith IC50between 0.99 and 5.39 mg/mL. This investigation provides data about the chemical variation among different parts of A. graveolensand encourages the use of its EOs as natural phytotoxic and antibacterial agents in agriculture, food and pharmaceutical sectors.

Published
2024
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46. Fatty Acid Profiles and Biological Activities of the Vegetable Oils of Argania spinosa , Pinus halepensis and Pistacia atlantica Grown in Tunisia: A Preliminary Study.

Author

Khammassi, Marwa, Amato, Giuseppe, Caputo, Lucia, Nazzaro, Filomena, Fratianni, Florinda, Kouki, Habiba, Amri, Ismail, Hamrouni, Lamia, and De Feo, Vincenzo

Subjects
VEGETABLE oils, ALEPPO pine, FATTY acids, PISTACIA, LINOLEIC acid, RHAMNOLIPIDS
Abstract

Several foods are used in both the nutraceutical and health sectors; vegetable oils, for example, can prevent the onset of numerous diseases. The properties of these oils are related to their chemical composition and primarily to the presence of fatty acids. The present work aimed to determine the chemical profiles of Argania spinosa, Pinus halepensis, and Pistacia altantica oils, used in traditional Tunisian foods, and to evaluate some biological properties. We evaluated their antioxidant, anti-enzymatic, antimicrobial, and anti-inflammatory properties. Linoleic acid was the main component of the three oils. P. atlantica oil showed more significant inhibitory activity against the enzymes studied than A. spinosa and P. halepensis. All three oils showed similar antioxidant and anti-inflammatory activity. Furthermore, A. spinosa and P. halepensis oils showed antibiofilm activity against P. aeruginosa, with 30–40% inhibition. These results focus on the possible use of these oils in the nutraceutical and healthcare sectors. [ABSTRACT FROM AUTHOR]

Published
2024
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47. In Vitro Screening of Antimicrobial and Anti-Coagulant Activities, ADME Profiling, and Molecular Docking Study of Citrus limon L. and Citrus paradisi L. Cold-Pressed Volatile Oils.

Author

Hamdi, Assia, Horchani, Mabrouk, Jannet, Hichem Ben, Snoussi, Mejdi, Noumi, Emira, Bouali, Nouha, Kadri, Adel, Polito, Flavio, De Feo, Vincenzo, and Edziri, Hayet

Subjects
LEMON, ESSENTIAL oils, MOLECULAR docking, MONOTERPENES, ECHINOCANDINS, RODENTICIDES, CYTIDINE deaminase, PARTIAL thromboplastin time
Abstract

Citrus, which belongs to the Rutaceae family, is a very widespread genus in the Mediterranean Basin. In Tunisia, various parts of these spontaneous or cultivated plants are used in common dishes or in traditional medicine. The purpose of this work was to investigate C. limon and C. paradisi essential oil (EO). The samples were studied for their chemical composition using SPME/MS, as well as their antibacterial and antifungal activities. Prothrombin time (PT) and activated partial thromboplastin time (aPTT) methods were used to evaluate the anticoagulant potentialities. The obtained results show that both essential oils are rich in monoterpenes hydrocarbons, whereby limonene is the main compound in C. paradisi EO (86.8%) and C. limon EO (60.6%). Moreover, C. paradisi EO contains β-pinene (13.3%), sabinene (2.2%) and α-pinene (2.1%). The antibacterial assay of the essential oils showed important bactericidal and fungicidal effects against all strains tested. In fact, the MICs values of C. limon EO ranged from 0.625 to 2.5 mg/mL against all Gram-positive and Gram-negative bacteria, and from 6.25 to 12.5 mg/mL for Candida spp. strains, while C. paradisi EO was more active against all bacteria with low MICs values ranging from 0.192 to 0.786 mg/mL, and about 1.5 mg/mL against Candida species. Both tested Citrus EOs exhibited interesting anticoagulant activities as compared to heparin. The molecular docking approach was used to study the binding affinity and molecular interactions of all identified compounds with active sites of cytidine deaminase from Klebsiella pneumoniae (PDB: 6K63) and the C (30) carotenoid dehydrosqualene synthase from Staphylococcus aureus (PDB: 2ZCQ). The obtained results show that limonene had the highest binding score of −4.6 kcal.mol−1 with 6K63 enzyme, and −6.7 kcal.mol−1 with 2ZCQ receptor. The ADME profiling of the major constituents confirmed their important pharmacokinetic and drug-like properties. Hence, the obtained results highlight the potential use of both C. limon and C. paradisi essential oils as sources of bioactive compounds with antibacterial, antifungal, and anti-coagulant activities. [ABSTRACT FROM AUTHOR]

Published
2023
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49. Contributors

Author

Abbamondi, Gennaro Roberto, primary, Ayala-Zavala, Fernando Jesus, additional, Bellezza, Ilaria, additional, Berber, Didem, additional, Coppola, Raffaele, additional, Costantino, Valeria, additional, Cutignano, Adele, additional, d’Acierno, Antonio, additional, De Feo, Vincenzo, additional, Della Sala, Gerardo, additional, Esposito, Germana, additional, Finore, Ilaria, additional, Fratianni, Florinda, additional, Gökalsın, Barış, additional, Gomes-Cruz, Adriano, additional, Granato, Daniel, additional, Jimenez, Angel G., additional, Kambourova, Margarita, additional, Kırtel, Onur, additional, Lami, Raphaël, additional, Minelli, Alba, additional, Nazzaro, Filomena, additional, Nicolaus, Barbara, additional, Toksoy Öner, Ebru, additional, Peirce, Matthew J., additional, Poli, Annarita, additional, Quax, Wim J., additional, Sesal, Nüzhet Cenk, additional, Sperandio, Vanessa, additional, Teta, Roberta, additional, Van den Ende, Wim, additional, Versluys, Maxime, additional, and Vogel, Jan, additional

Published
2019
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