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6 results on '"De Joannon, U."'

1. Pravastatin vs Gemfibrozil in the Treatment of Primary Hypercholesterolaemia

Author

Malacco, E., Magni, Alberto, Scandiani, L., Casini, A., Albano, S., Ansuini, R., Biasion, T., Biffi, E., Bilardo, G., Boccuzzi, G., Breda, E., Buttafarro, A., Chella, P. S., Chieffo, C., Coletta, D., Coli, L., Colombo, L., Compagnoni, A., D’Amico, G., D’Ascia, C., De Gregori, M., De Joannon, U., Distante, R., Donadon, V., Donnini, P., Fallucca, F., Ferrari, L., Fesce, E., Formoso, L., Furlani, M., Galetta, F., Gianni, R., Giustina, G., Irace, L., Lipizer, A., Maggio, F., Magri, F., Mangiameli, S., Marasco, S., Marchetti, M., Marrazza, B., Melandri, F., Mondillo, G., Montagnani, M., Napoli, C., Neri, G. F., Orlandi, M., Pantaleoni, M., Papa, A., Perrella, G., Pileggi, V., Pilleri, G. P., Pittalis, M., Piva, M., Resta, F., Rodari, T., Savastano, A., Savona, M., Sensi, S., Sorrentino, F., Squadrito, S., Stocchiero, C., Stranieri, A., Susco, G., Tani, F., Tassone, F., Taverniti, R., Terrosu, P. F., Tirella, G., and Vicario, A.

Published
1994
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2. Sexual dysfunction in type 2 diabetes at diagnosis: Progression over time and drug and non-drug correlated factors

Author

Corona, G., Giorda, Carlo B., Cucinotta, Domenico, Guida, Piero, Nada, Elisa, Aglialoro, A., Albanese, V., Albano, S., Antonangelo, C., Baccetti, F., Bulzomi, R., Calatola, P., Capano, F., Clemente, G., Corigliano, G., Cucinotta, D., De Fazio, C., DE FRANCESCO, Claudia, De Joannon, U., Del Buono, A., Fontana, L., Fornengo, R., Fraticelli, E., Gaviglio, D., Gentile, S., Giorda, C. B., Giorgianni, Letterio, Guarino, G., Iannarelli, R., Improta, L., Improta, M., Leotta, S., Magro, G., Maiani, L., Mastroiacovo, D., Mingardi, R., Morviducci, L., Nada, E., Nosso, G., Nuzzi, A., Ocelli, C., Paciotti, V., Pata, P., Rampini, P. A., Rovere, M., Sabbatini, A., Sciarrafia, M., Sciarretta, F., Sforza, A., Starnone, V., Testori, G., Trevisan, F., Turco, S., Viviani, G., and Zavaroni, D.

Subjects
Male, Cross-sectional study, Aged, Cross-Sectional Studies, Depressive Disorder, Diabetes Mellitus, Type 2, Erectile Dysfunction, Follow-Up Studies, Humans, Hypoglycemic Agents, Interviews as Topic, Life Style, Middle Aged, Phosphodiesterase 5 Inhibitors, Prevalence, Prospective Studies, Severity of Illness Index, Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), 030232 urology & nephrology, lcsh:Medicine, Type 2 diabetes, Biochemistry, 0302 clinical medicine, Endocrinology, Drug Metabolism, Medicine and Health Sciences, Testosterone, Lipid Hormones, lcsh:Science, Prospective cohort study, 030219 obstetrics & reproductive medicine, Multidisciplinary, Pharmaceutics, Depression, Obstetrics and Gynecology, Type 2 Diabetes, Androgens, medicine.symptom, sexual disfunction, Research Article, medicine.medical_specialty, Sexual Dysfunction, Endocrine Disorders, Urology, PDE5i, 03 medical and health sciences, Drug Therapy, Internal medicine, Severity of illness, Mental Health and Psychiatry, medicine, Diabetes Mellitus, Pharmacokinetics, Pharmacology, business.industry, Mood Disorders, Hypogonadism, lcsh:R, Type 2 Diabetes Mellitus, Biology and Life Sciences, medicine.disease, Hormones, Surgery, Erectile dysfunction, Sexual dysfunction, Metabolic Disorders, Women's Health, lcsh:Q, Sexual function, business
Abstract

Aims To present the longitudinal data of the SUBITO-DE study, a prospective survey involving male patients with new or recently diagnosed type 2 diabetes mellitus (T2DM) (

Published
2016
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3. The SUBITO-DE study: sexual dysfunction in newly diagnosed type 2 diabetes male patients

Author

Corona G1, Giorda CB, Cucinotta D, Guida P, Nada E, SUBITO DE study g.r.o.u.p. CollaboratorsAglialoro A, Albanese V, Albano S, Antonangelo C, Baccetti F, Bulzomì R, Calatola P, Capano F, Clemente G, Corigliano G, Corona G, De Fazio C, De Francesco C, De Joannon U, Del Buono A, Fontana L, Fornengo R, Fraticelli E, Gaviglio D, GENTILE, Sandro, Giorgianni L, GUARINO, Giuseppina, Iannarelli R, Improta L, Improta M, Leotta S, Magro G, Maiani L, Mingardi R, Morviducci L, Nosso G, Nuzzi A, Ocelli C, Paciotti V, Pata P, Rampini PA, Rovere M, Sabbatini A, Sciarrafia M, Sciarretta F, Sforza A, Starnone V, Testori G, Trevisan F, Turco S, Viviani G, Zavaroni D., Corona, G1, Giorda, Cb, Cucinotta, D, Guida, P, Nada, E, CollaboratorsAglialoro A, SUBITO DE study g. r. o. u. p., Albanese, V, Albano, S, Antonangelo, C, Baccetti, F, Bulzomì, R, Calatola, P, Capano, F, Clemente, G, Corigliano, G, Corona, G, De Fazio, C, De Francesco, C, De Joannon, U, Del Buono, A, Fontana, L, Fornengo, R, Fraticelli, E, Gaviglio, D, Gentile, Sandro, Giorgianni, L, Guarino, Giuseppina, Iannarelli, R, Improta, L, Improta, M, Leotta, S, Magro, G, Maiani, L, Mingardi, R, Morviducci, L, Nosso, G, Nuzzi, A, Ocelli, C, Paciotti, V, Pata, P, Rampini, Pa, Rovere, M, Sabbatini, A, Sciarrafia, M, Sciarretta, F, Sforza, A, Starnone, V, Testori, G, Trevisan, F, Turco, S, Viviani, G, and Zavaroni, D.

Subjects
Male, Depression, Hypogonadism, Comorbidity, Middle Aged, Prognosis, Cross-Sectional Studies, Diabetes Mellitus, Type 2, Erectile Dysfunction, Risk Factors, Humans, Testosterone, Longitudinal Studies, Prospective Studies, Follow-Up Studies
Abstract

No data on the prevalence of erectile dysfunction (ED) in subjects with newly diagnosed Type 2 diabetes mellitus (T2DM) are currently available.The aim of the present study was to estimate the prevalence of ED and its associated causes in a sample of male patients with recently diagnosed DM (24 months) attending a diabetes care center.The study comprised two phases: a cross-sectional analysis and a longitudinal reassessment of the data collected during the first phase. During the first phase, 1503 subjects (mean age 58.7±8.9 yr) from 27 centers were interviewed: 666 (43.3%) reported experiencing ED, 499 of which (mean age 58.8±8.8 yr) agreed to participate in the study (final enrolment rate, 33.3%). Concurrent morbidities were hypertension (55.3%), dyslipidemia (39.5%), and coronary heart disease (7.8%); chronic complications were neuropathy (8.9%), nephropathy (12.6%) and retinopathy (7.6%) in about one third of the sample at enrolment.Overall, about 20% of the patients reported having used ED drugs, but more than 50% had abandoned therapy because of the drug's ineffectiveness or high cost. The prevalence of hypogonadism was 46.9% (total testosterone level, 3.5 ng/ml). Some 20% of patients reported symptoms suggestive of depression.The present study provides data showing a high prevalence of ED, hypogonadism and depressive symptoms among male patients with newly diagnosed T2DM. Further analysis of the data will elucidate the specific determinants of such conditions and their longitudinal significance.

Published
2013

4. Sexual dysfunction at the onset of type 2 diabetes: the interplay of depression, hormonal and cardiovascular factors

Author

Corona G., Giorda C.B., Cucinotta D., Guida P., Nada E., Aglialoro A., Albanese V., Albano S., Antonangelo C., Baccetti F., Bulzomi' R., Calatola P., Capano F., Clemente G., Corigliano G., De Fazio C., De Francesco C., De Joannon U., Del Buono A., Fontana L., Fornengo R., Fraticelli E., Gaviglio D., Gentile S., Giorgianni L., Guarino G., Iannarelli R., Improta L., Improta M., Leotta S., Magro G., Maiani L., Mingardi R., Morviducci L., Nosso G., Nuzzi A., Ocelli C., Paciotti V., Pata P., Rampini P.A., Rovere M., Sabbatini A., Sciarrafia M., Sciarretta F., Sforza A., Starnone V., Testori G., Trevisan F., Turco S., Viviani G., Zavaroni D., Gentile, Sandro, Giorda, C. B., Giorgianni, L., and Guarino, Giuseppina

Subjects
Male, medicine.medical_specialty, Urology, Endocrinology, Diabetes and Metabolism, Libido, Type 2 diabetes, Endocrinology, Diabetes mellitus, Erectile Dysfunction, Testosterone, Diabetes Mellitus, Internal medicine, Premature ejaculation, medicine, Prevalence, Humans, Ejaculation, Prospective Studies, Premature Ejaculation, Depression (differential diagnoses), Depressive Disorder, business.industry, Hypogonadism, Delayed ejaculation, Middle Aged, medicine.disease, Psychiatry and Mental health, Sexual desire, Sexual Dysfunction, Physiological, Sexual dysfunction, Erectile dysfunction, Reproductive Medicine, Diabetes Mellitus, Type 2, Italy, medicine.symptom, business, Sexual function
Abstract

Introduction: Several data have emphasized the importance of early diagnosis of erectile dysfunction (ED) and meticulous cardiovascular investigation in the type 2 diabetic mellitus (T2DM) patients. Aim: To estimate the prevalence of ED and its associated determinants in a sample of male patients with new or recently diagnosed T2DM. Methods: The SUBITO-DE study is an observational, multicenter, prospective study involving 27 Italian diabetes centers. Male patients recently diagnosed with T2DM were consecutively interviewed by their attending physician at the diabetes care centers and asked whether they had experienced a change in their sexual function or found it unsatisfactory. Those responding positively were then invited to participate in the study. Main Outcome Measure: Several hormonal and biochemical parameters were studied. Results: A nonselected series of 1,503 patients was interviewed, 499 of which (mean age, 58.8±8.8 years) entered the study, yielding a final enrolment rate of 33.3%. ED was classified as mild in 19.4%, mild-to-moderate in 15.4%, moderate in 10.4%, and severe in 21.6% of patients, respectively. In addition, premature ejaculation, delayed ejaculation, and hypoactive sexual desire (HSD) were comorbid in 28.3%, 32.9%, and 58.4%, respectively. Finally, hypogonadism, showed an estimated prevalence of almost 20%. Both organic (at least one chronic DM-associated complication) and psychological factors (severe depressive symptoms) increased the risk of ED. Severe depressive symptoms were also associated with ejaculatory problems, HSD, and hypogonadism. Conclusions: A high prevalence of sexual dysfunction in men with recently diagnosed T2DM was detected. Early diagnosis of ED could help prevent emotional and physical discomfort in men and aid in identifying reversible cardiovascular risk factors. Screening of sexual dysfunction should become a part of routine care in the management of T2DM patients. Corona G, Giorda CB, Cucinotta D, Guida P, Nada E, and Gruppo di studio SUBITO-DE. Sexual dysfunction at the onset of type 2 diabetes: The interplay of depression, hormonal and cardiovascular factors. J Sex Med 2014;11:2065-2073. © 2014 International Society for Sexual Medicine.

Published
2014
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5. Pravastatin vsGemfibrozil in the Treatment of Primary Hypercholesterolaemia

Author

Malacco, E., Magni, Alberto, Scandiani, L., Casini, A., Albano, S., Ansuini, R., Biasion, T., Biffi, E., Bilardo, G., Boccuzzi, G., Breda, E., Buttafarro, A., Chella, P. S., Chieffo, C., Coletta, D., Coli, L., Colombo, L., Compagnoni, A., D’Amico, G., D’Ascia, C., De Gregori, M., De Joannon, U., Distante, R., Donadon, V., Donnini, P., Fallucca, F., Ferrari, L., Fesce, E., Formoso, L., Furlani, M., Galetta, F., Gianni, R., Giustina, G., Irace, L., Lipizer, A., Maggio, F., Magri, F., Mangiameli, S., Marasco, S., Marchetti, M., Marrazza, B., Melandri, F., Mondillo, G., Montagnani, M., Napoli, C., Neri, G. F., Orlandi, M., Pantaleoni, M., Papa, A., Perrella, G., Pileggi, V., Pilleri, G. P., Pittalis, M., Piva, M., Resta, F., Rodari, T., Savastano, A., Savona, M., Sensi, S., Sorrentino, F., Squadrito, S., Stocchiero, C., Stranieri, A., Susco, G., Tani, F., Tassone, F., Taverniti, R., Terrosu, P. F., Tirella, G., and Vicario, A.

Abstract

An increase in total and low density lipoprotein (LDL) cholesterol concentrations is related to the incidence of cardiovascular heart disease. The purpose of this study was to compare the efficacy and safety of pravastatin, an HMG-CoA reductase inhibitor, versus gemfibrozil, a fibrate, in the treatment of primary hypercholesterolaemia. 855 subjects (males and females, aged between 18 and 70 years) with total cholesterol (TC) concentrations > 240 mg/dl and triglyceride (TG) concentrations < 250 mg/dl were enrolled. After a pretreatment diet period, patients received either pravastatin 20 mg/day (659 patients) or gemfibrozil 1200 mg/day (196 patients). At the end of the 12-week treatment period, reductions in TC (−23%) and LDL-C (−31%) were noted in the pravastatin group. Gemfibrozil reduced TC by 16% and LDL by 20%. High density lipoprotein (HDL) cholesterol concentrations increased in a similar way in the two groups: pravastatin +10%, gemfibrozil+11%. Triglycerides decreased by 14% with pravastatin and by 22% with gemfibrozil. Pravastatin and gemfibrozil were both well tolerated. No significant adverse events or variations in laboratory parameters occurred during this study.

Published
1994
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6. Beta-cell behavior, evaluated as basal and mixed meal-stimulated insulin, and proinsulin secretion, in elderly diabetic patients with "secondary failure".

Author

Zavaroni D, Borghi MF, Pierfranceschi MG, Bianco M, De Joannon U, and Pierfranceschi DG

Subjects
Aged, Diabetes Mellitus blood, Diabetes Mellitus metabolism, Female, Humans, Insulin blood, Insulin Secretion, Male, Proinsulin blood, Diabetes Mellitus physiopathology, Food, Insulin metabolism, Islets of Langerhans metabolism, Proinsulin metabolism
Published
1999

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