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17 results on '"De Laurentiis, Annamaria"'

2. Supplementary Methods from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy

Author

Tuccillo, Franca Maria, primary, Palmieri, Camillo, primary, Fiume, Giuseppe, primary, de Laurentiis, Annamaria, primary, Schiavone, Marco, primary, Falcone, Cristina, primary, Iaccino, Enrico, primary, Galandrini, Ricciarda, primary, Capuano, Cristina, primary, Santoni, Angela, primary, D'Armiento, Francesco Paolo, primary, Arra, Claudio, primary, Barbieri, Antonio, primary, Dal Piaz, Fabrizio, primary, Venzon, David, primary, Bonelli, Patrizia, primary, Buonaguro, Franco Maria, primary, Scala, Iris, primary, Mallardo, Massimo, primary, Quinto, Ileana, primary, and Scala, Giuseppe, primary

Published
2023
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3. Supplementary Figures 1 - 4 from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy

Author

Tuccillo, Franca Maria, primary, Palmieri, Camillo, primary, Fiume, Giuseppe, primary, de Laurentiis, Annamaria, primary, Schiavone, Marco, primary, Falcone, Cristina, primary, Iaccino, Enrico, primary, Galandrini, Ricciarda, primary, Capuano, Cristina, primary, Santoni, Angela, primary, D'Armiento, Francesco Paolo, primary, Arra, Claudio, primary, Barbieri, Antonio, primary, Dal Piaz, Fabrizio, primary, Venzon, David, primary, Bonelli, Patrizia, primary, Buonaguro, Franco Maria, primary, Scala, Iris, primary, Mallardo, Massimo, primary, Quinto, Ileana, primary, and Scala, Giuseppe, primary

Published
2023
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4. Data from Cancer-Associated CD43 Glycoforms as Target of Immunotherapy

Author

Tuccillo, Franca Maria, primary, Palmieri, Camillo, primary, Fiume, Giuseppe, primary, de Laurentiis, Annamaria, primary, Schiavone, Marco, primary, Falcone, Cristina, primary, Iaccino, Enrico, primary, Galandrini, Ricciarda, primary, Capuano, Cristina, primary, Santoni, Angela, primary, D'Armiento, Francesco Paolo, primary, Arra, Claudio, primary, Barbieri, Antonio, primary, Dal Piaz, Fabrizio, primary, Venzon, David, primary, Bonelli, Patrizia, primary, Buonaguro, Franco Maria, primary, Scala, Iris, primary, Mallardo, Massimo, primary, Quinto, Ileana, primary, and Scala, Giuseppe, primary

Published
2023
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6. In vivo targeting and growth inhibition of the A20 murine B-cell lymphoma by an idiotype-specific peptide binder

Author

Palmieri, Camillo, Falcone, Cristina, Iaccino, Enrico, Tuccillo, Franca Maria, Gaspari, Marco, Trimboli, Francesca, De Laurentiis, Annamaria, Luberto, Laura, Pontoriero, Marilena, Pisano, Antonio, Vecchio, Eleonora, Fierro, Olga, Panico, Maria Rosaria, Larobina, Michele, Gargiulo, Sara, Costa, Nicola, Dal Piaz, Fabrizio, Schiavone, Marco, Arra, Claudio, Giudice, Aldo, Palma, Giuseppe, Barbieri, Antonio, Quinto, Ileana, and Scala, Giuseppe

Published
2010
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8. Aberrant Glycosylation as Biomarker for Cancer: Focus on CD43

Author

Tuccillo, Franca Maria, de Laurentiis, Annamaria, Palmieri, Camillo, Fiume, Giuseppe, Bonelli, Patrizia, Borrelli, Antonella, Tassone, Pierfrancesco, Scala, Iris, Buonaguro, Franco Maria, Quinto, Ileana, and Scala, Giuseppe

Subjects
carbohydrates (lipids), Article Subject
Abstract

Glycosylation is a posttranslational modification of proteins playing a major role in cell signalling, immune recognition, and cell-cell interaction because of their glycan branches conferring structure variability and binding specificity to lectin ligands. Aberrant expression of glycan structures as well as occurrence of truncated structures, precursors, or novel structures of glycan may affect ligand-receptor interactions and thus interfere with regulation of cell adhesion, migration, and proliferation. Indeed, aberrant glycosylation represents a hallmark of cancer, reflecting cancer-specific changes in glycan biosynthesis pathways such as the altered expression of glycosyltransferases and glycosidases. Most studies have been carried out to identify changes in serum glycan structures. In most cancers, fucosylation and sialylation are significantly modified. Thus, aberrations in glycan structures can be used as targets to improve existing serum cancer biomarkers. The ability to distinguish differences in the glycosylation of proteins between cancer and control patients emphasizes glycobiology as a promising field for potential biomarker identification. In this review, we discuss the aberrant protein glycosylation associated with human cancer and the identification of protein glycoforms as cancer biomarkers. In particular, we will focus on the aberrant CD43 glycosylation as cancer biomarker and the potential to exploit the UN1 monoclonal antibody (UN1 mAb) to identify aberrant CD43 glycoforms.

Published
2014
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9. CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation

Author

Pisano, Antonio, primary, Ceglia, Simona, additional, Palmieri, Camillo, additional, Vecchio, Eleonora, additional, Fiume, Giuseppe, additional, de Laurentiis, Annamaria, additional, Mimmi, Selena, additional, Falcone, Cristina, additional, Iaccino, Enrico, additional, Scialdone, Annarita, additional, Pontoriero, Marilena, additional, Masci, Francesca Fasanella, additional, Valea, Rosanna, additional, Krishnan, Shibu, additional, Gaspari, Marco, additional, Cuda, Giovanni, additional, Scala, Giuseppe, additional, and Quinto, Ileana, additional

Published
2015
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10. Cancer-Associated CD43 Glycoforms as Target of Immunotherapy

Author

Tuccillo, Franca Maria, primary, Palmieri, Camillo, additional, Fiume, Giuseppe, additional, de Laurentiis, Annamaria, additional, Schiavone, Marco, additional, Falcone, Cristina, additional, Iaccino, Enrico, additional, Galandrini, Ricciarda, additional, Capuano, Cristina, additional, Santoni, Angela, additional, D'Armiento, Francesco Paolo, additional, Arra, Claudio, additional, Barbieri, Antonio, additional, Dal Piaz, Fabrizio, additional, Venzon, David, additional, Bonelli, Patrizia, additional, Buonaguro, Franco Maria, additional, Scala, Iris, additional, Mallardo, Massimo, additional, Quinto, Ileana, additional, and Scala, Giuseppe, additional

Published
2014
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11. Eukaryotic Initiation Factor 4H Is under Transcriptional Control of p65/NF-κB

Author

Fiume, Giuseppe, primary, Rossi, Annalisa, additional, de Laurentiis, Annamaria, additional, Falcone, Cristina, additional, Pisano, Antonio, additional, Vecchio, Eleonora, additional, Pontoriero, Marilena, additional, Scala, Iris, additional, Scialdone, Annarita, additional, Masci, Francesca Fasanella, additional, Mimmi, Selena, additional, Palmieri, Camillo, additional, Scala, Giuseppe, additional, and Quinto, Ileana, additional

Published
2013
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12. Design and Characterization of a Peptide Mimotope of the HIV-1 gp120 Bridging Sheet

Author

Schiavone, Marco, primary, Fiume, Giuseppe, additional, Caivano, Antonella, additional, de Laurentiis, Annamaria, additional, Falcone, Cristina, additional, Masci, Francesca Fasanella, additional, Iaccino, Enrico, additional, Mimmi, Selena, additional, Palmieri, Camillo, additional, Pisano, Antonio, additional, Pontoriero, Marilena, additional, Rossi, Annalisa, additional, Scialdone, Annarita, additional, Vecchio, Eleonora, additional, Andreozzi, Concetta, additional, Trovato, Maria, additional, Rafay, Jan, additional, Ferko, Boris, additional, Montefiori, David, additional, Lombardi, Angela, additional, Morsica, Giulia, additional, Poli, Guido, additional, Quinto, Ileana, additional, Pavone, Vincenzo, additional, de Berardinis, Piergiuseppe, additional, and Scala, Giuseppe, additional

Published
2012
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13. Human immunodeficiency virus-1 Tat activates NF-κB via physical interaction with IκB-α and p65

Author

Fiume, Giuseppe, primary, Vecchio, Eleonora, additional, De Laurentiis, Annamaria, additional, Trimboli, Francesca, additional, Palmieri, Camillo, additional, Pisano, Antonio, additional, Falcone, Cristina, additional, Pontoriero, Marilena, additional, Rossi, Annalisa, additional, Scialdone, Annarita, additional, Fasanella Masci, Francesca, additional, Scala, Giuseppe, additional, and Quinto, Ileana, additional

Published
2011
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14. Mass Spectrometry-Based Identification Of The Tumor Antigen UN1 as the Transmembrane CD43 Sialoglycoprotein

Author

de Laurentiis, Annamaria, primary, Gaspari, Marco, additional, Palmieri, Camillo, additional, Falcone, Cristina, additional, Iaccino, Enrico, additional, Fiume, Giuseppe, additional, Massa, Ornella, additional, Masullo, Mariorosario, additional, Tuccillo, Franca Maria, additional, Roveda, Laura, additional, Prati, Ubaldo, additional, Fierro, Olga, additional, Cozzolino, Immacolata, additional, Troncone, Giancarlo, additional, Tassone, Pierfrancesco, additional, Scala, Giuseppe, additional, and Quinto, Ileana, additional

Published
2011
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15. CRL3IBTK Regulates the Tumor Suppressor Pdcd4 through Ubiquitylation Coupled to Proteasomal Degradation.

Author

Pisano, Antonio, Ceglia, Simona, Palmieri, Camillo, Vecchio, Eleonora, Fiume, Giuseppe, de Laurentiis, Annamaria, Mimmi, Selena, Falcone, Cristina, Iaccino, Enrico, Scialdone, Annarita, Pontoriero, Marilena, Masci, Francesca Fasanella, Valea, Rosanna, Krishnan, Shibu, Gaspari, Marco, Cuda, Giovanni, Scala, Giuseppe, and Quinto, Ileana

Subjects
*TUMOR suppressor proteins, *TUMOR suppressor genes, *PROTEIN kinases, *LYMPHOPROLIFERATIVE disorders, *CELL proliferation
Abstract

The human inhibitor of Bruton's tyrosine kinase isoform α (IBtkα) is a BTB protein encoded by the IBTK gene, which maps to chromosomal locus 6q14.1, a mutational hot spot in lymphoproliferative disorders. Here, we demonstrate that IBtkα forms a CRL3IBTK complex promoting its self-ubiquitylation. We identified the tumor suppressor Pdcd4 as IBtkα interactor and ubiquitylation substrate of CRL3IBTK for proteasomal degradation. Serum-induced degradation of Pdcd4 required both IBtkα and Cul3, indicating that CRL3IBTK regulated the Pdcd4 stability in serum signaling. By promoting Pdcd4 degradation, IBtkα counteracted the suppressive effect of Pdcd4 on translation of reporter luciferase mRNAs with stem-loop structured or unstructured 5'-UTR. IBtkα depletion by RNAi caused Pdcd4 accumulation and decreased the translation of Bcl-xL mRNA, a well known target of Pdcd4 repression. By characterizing CRL3IBTK as a novel ubiquitin ligase, this study provides new insights into regulatory mechanisms of cellular pathways, such as the Pdcd4-dependent translation of mRNAs. [ABSTRACT FROM AUTHOR]

Published
2015
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16. Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice

Author

Giancarlo Troncone, F. Tuccillo, Massimo Mallardo, Simona Ceglia, Enrico Iaccino, Selena Mimmi, Franco M. Buonaguro, Giuseppe Palma, Antonio Pisano, Ileana Quinto, Valter Agosti, Cristina Falcone, Eleonora Vecchio, Marilena Pontoriero, Annarita Scialdone, Domenica Rea, Annalisa Rossi, Camillo Palmieri, Elisabetta Caiazzo, Annamaria de Laurentiis, Francesco Albano, Claudio Bellevicine, Claudio Arra, Giuseppe Scala, Carla Cicala, Chiara Mignogna, Giuseppe Fiume, Fiume, Giuseppe, Scialdone, Annarita, Albano, Francesco, Rossi, Annalisa, Tuccillo, Franca Maria, Rea, Domenica, Palmieri, Camillo, Caiazzo, Elisabetta, Cicala, Carla, Bellevicine, Claudio, Falcone, Cristina, Vecchio, Eleonora, Pisano, Antonio, Ceglia, Simona, Mimmi, Selena, Iaccino, Enrico, de Laurentiis, Annamaria, Pontoriero, Marilena, Agosti, Valter, Troncone, Giancarlo, Mignogna, Chiara, Palma, Giuseppe, Arra, Claudio, Mallardo, Massimo, Buonaguro, Franco Maria, Scala, Giuseppe, and Quinto, Ileana

Subjects
Lipopolysaccharides, Genetically modified mouse, Chemokine, T cell, Gene Expression, HIV Infections, Mice, Transgenic, Inflammation, Thymus Gland, Biology, Article, Lymphocyte Depletion, Proinflammatory cytokine, Mice, Immune system, T-Lymphocyte Subsets, medicine, Animals, Cluster Analysis, Lymphocyte Count, Lymphopoiesis, Thymocytes, Multidisciplinary, Gene Expression Profiling, NF-kappa B, Cell Differentiation, MicroRNAs, medicine.anatomical_structure, Immunology, HIV-1, biology.protein, Cytokines, tat Gene Products, Human Immunodeficiency Virus, medicine.symptom, CD8
Abstract

Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a transgenic mouse expressing Tat in lymphoid tissue. Tat-Tg mice showed thymus atrophy and the maturation block from DN4 to DP thymic subpopulations, resulting in CD4+ and CD8+ T cells depletion in peripheral blood. In Tat-positive thymus, we observed the increased p65/NF-κB activity and deregulated expression of cytokines/chemokines and microRNA-181a-1, which are involved in T-lymphopoiesis. Upon LPS intraperitoneal injection, Tat-Tg mice developed an abnormal acute inflammatory response, which was characterized by enhanced lethality and production of inflammatory cytokines. Based on these findings, Tat-Tg mouse could represent an animal model for testing adjunctive therapies of HIV-1-associated inflammation and immune deregulation.

Published
2015

17. Impairment of T cell development and acute inflammatory response in HIV-1 Tat transgenic mice.

Author

Fiume G, Scialdone A, Albano F, Rossi A, Tuccillo FM, Rea D, Palmieri C, Caiazzo E, Cicala C, Bellevicine C, Falcone C, Vecchio E, Pisano A, Ceglia S, Mimmi S, Iaccino E, de Laurentiis A, Pontoriero M, Agosti V, Troncone G, Mignogna C, Palma G, Arra C, Mallardo M, Buonaguro FM, Scala G, and Quinto I

Subjects
Animals, Cluster Analysis, Cytokines blood, Cytokines genetics, Cytokines metabolism, Gene Expression, Gene Expression Profiling, HIV Infections metabolism, HIV Infections virology, Lipopolysaccharides immunology, Lymphocyte Count, Lymphocyte Depletion, Lymphopoiesis, Mice, Mice, Transgenic, MicroRNAs genetics, NF-kappa B metabolism, T-Lymphocyte Subsets metabolism, Thymocytes cytology, Thymocytes immunology, Thymus Gland cytology, Thymus Gland immunology, Thymus Gland metabolism, Cell Differentiation, HIV Infections immunology, HIV-1 genetics, HIV-1 immunology, T-Lymphocyte Subsets cytology, T-Lymphocyte Subsets immunology, tat Gene Products, Human Immunodeficiency Virus genetics
Abstract

Immune activation and chronic inflammation are hallmark features of HIV infection causing T-cell depletion and cellular immune dysfunction in AIDS. Here, we addressed the issue whether HIV-1 Tat could affect T cell development and acute inflammatory response by generating a transgenic mouse expressing Tat in lymphoid tissue. Tat-Tg mice showed thymus atrophy and the maturation block from DN4 to DP thymic subpopulations, resulting in CD4(+) and CD8(+) T cells depletion in peripheral blood. In Tat-positive thymus, we observed the increased p65/NF-κB activity and deregulated expression of cytokines/chemokines and microRNA-181a-1, which are involved in T-lymphopoiesis. Upon LPS intraperitoneal injection, Tat-Tg mice developed an abnormal acute inflammatory response, which was characterized by enhanced lethality and production of inflammatory cytokines. Based on these findings, Tat-Tg mouse could represent an animal model for testing adjunctive therapies of HIV-1-associated inflammation and immune deregulation.

Published
2015
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