Search

Your search keyword '"De Lazzari, Michael"' showing total 3 results
Start Over Author "De Lazzari, Michael"
Sorry, I don't understand your search. ×
3 results on '"De Lazzari, Michael"'

1. High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source

Author

Cole, Jason M., Symes, Daniel R., Lopes, Nelson C., Wood, Jonathan C., Poder, Kristjan, Alatabi, Saleh, Botchway, Stanley W., Foster, Peta S., Gratton, Sarah, Johnson, Sara, Kamperidis, Christos, Kononenko, Olena, De Lazzari, Michael, Palmer, Charlotte A. J., Rusby, Dean, Sanderson, Jeremy, Sandholzer, Michael, Sarri, Gianluca, Szoke-Kovacs, Zsombor, Teboul, Lydia, Thompson, James M., Warwick, Jonathan R., Westerberg, Henrik, Hill, Mark A., Norris, Dominic P., Mangles, Stuart P. D., and Najmudin, Zulfikar

Published
2018

2. High-resolution #956;CT of a mouse embryo using a compact laser-driven X-ray betatron source.

Author

Cole, Jason M., Symes, Daniel R., Lopes, Nelson C., Wood, Jonathan C., Poder, Kristjan, Alatabi, Saleh, Botchway, Stanley W., Foster, Peta S., Gratton, Sarah, Johnson, Sara, Kamperidis, Christos, Kononenko, Olena, De Lazzari, Michael, Palmer, Charlotte A. J., Rusby, Dean, Sanderson, Jeremy, Sandholzer, Michael, Sarri, Gianluca, Szoke-Kovacs, Zsombor, and Teboul, Lydia

Subjects
X-ray computed microtomography, HIGH resolution imaging, MICE embryology, X-ray imaging, LABORATORY mice, LASER plasma accelerators
Abstract

In the field of X-ray microcomputed tomography (μCT) there is a growing need to reduce acquisition times at high spatial resolution (approximate micrometers) to facilitate in vivo and high-throughput operations. The state of the art represented by synchrotron light sources is not practical for certain applications, and therefore the development of high-brightness laboratoryscale sources is crucial. We present here imaging of a fixed embryonic mouse sample using a compact laser-plasma-based X-ray light source and compare the results to images obtained using a commercial X-ray μCT scanner. The radiation is generated by the betatron motion of electrons inside a dilute and transient plasma, which circumvents the flux limitations imposed by the solid or liquid anodes used in conventional electron-impact X-ray tubes. This X-ray source is pulsed (duration <30 fs), bright (>1010 photons per pulse), small (diameter <1 μm), and has a critical energy >15 keV. Stable X-ray performance enabled tomographic imaging of equivalent quality to that of the μCT scanner, an important confirmation of the suitability of the laserdriven source for applications. The X-ray flux achievable with this approach scales with the laser repetition rate without compromising the source size, which will allow the recording of high-resolution μCT scans in minutes. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

3. High-resolution μCT of a mouse embryo using a compact laser-driven X-ray betatron source

Author

Cole, Jason M., Symes, Daniel R., Lopes, Nelson C., Wood, Jonathan C., Poder, Kristjan, Alatabi, Saleh, Botchway, Stanley W., Foster, Peta S., Gratton, Sarah, Johnson, Sara, Kamperidis, Christos, Kononenko, Olena, De Lazzari, Michael, Palmer, Charlotte, Rusby, Dean, Sanderson, Jeremy, Sandholzer, Michael, Sarri, Gianluca, Szoke-Kovacs, Zsombor, Teboul, Lydia, Thompson, James M., Warwick, Jonathan R., Westerberg, Henrik, Hill, Mark A., Norris, Dominic P., Mangles, Stuart P. D., and Najmudin, Zulfikar

Subjects
3. Good health
Abstract

Proceedings of the National Academy of Sciences of the United States of America 115(25), 6335 - 6340 (2018). doi:10.1073/pnas.1802314115, In the fieldof X-raymicrocomputedtomography(μCT) thereis a growingneedto reduceacquisitiontimesat highspatialresolution(approximatemicrometers)to facilitatein vivoandhigh-throughputoperations.The stateof the art representedbysynchrotron lightsources is not practicalfor certainapplications,andtherefore the developmentof high-brightnesslaboratory-scalesources is crucial.We presenthere imagingof a fixedembryonicmousesampleusinga compactlaser–plasma-basedX-raylightsource andcompare the resultsto imagesobtainedusinga commercial X-rayμCT scanner. The radiationis generatedby the betatron motionof electrons insidea diluteandtran-sientplasma,whichcircumventsthe flux limitationsimposedbythe solidor liquidanodesusedin conventionalelectron-impactX-raytubes.This X-raysource is pulsed(duration1010photonsper pulse),small(diameter15 keV. StableX-rayperformanceenabledtomographicimagingof equivalentqualityto thatof theμCTscanner, an importantconfirmationof the suitabilityof the laser-drivensource for applications.TheX-rayfluxachievablewiththis approachscaleswiththe laserrepetitionratewithoutcom-promisingthe source size,whichwillallowthe recordingofhigh-resolutionμCT scansin minutes., Published by National Acad. of Sciences, Washington, DC

Catalog

Books, media, physical & digital resources
See catalog results