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21 results on '"De Lodovici, Maria Luisa"'

1. Prestroke CHA2DS2-VASc Score and Severity of Acute Stroke in Patients with Atrial Fibrillation: Findings from RAF Study

Author

Acciarresi, Monica, Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Morotti, Andrea, Costa, Paolo, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, D'Amore, Cataldo, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D'Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria Giulia, and Lees, Kennedy R.

Published
2017
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2. The role of clinical and neuroimaging features in the diagnosis of CADASIL

Author

Bersano, Anna, Bedini, Gloria, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, Corato, Manuel, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, and on behalf of Lombardia GENS-group

Published
2018
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3. Anticoagulation After Stroke in Patients With Atrial Fibrillation: To Bridge or Not With Low-Molecular-Weight Heparin?

Author

Altavilla, Riccardo, Caso, Valeria, Bandini, Fabio, Agnelli, Giancarlo, Tsivgoulis, Georgios, Yaghi, Shadi, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Giulia Mosconi, Maria, Anna Cimini, Ludovica, Fusaro, Jessica, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Lanari, Alessia, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D’Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Maria Lotti, Enrico, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, and Paciaroni, Maurizio

Published
2019
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4. Prognostic value of trans-thoracic echocardiography in patients with acute stroke and atrial fibrillation: findings from the RAF study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria Giulia, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D’Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, and Lees, Kennedy R.

Published
2016
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5. Prediction of Early Recurrent Thromboembolic Event and Major Bleeding in Patients With Acute Stroke and Atrial Fibrillation by a Risk Stratification Schema: The ALESSA Score Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Caso, Valeria, Tsivgoulis, Georgios, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Falocci, Nicola, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Mosconi, Maria Giulia, Cimini, Ludovica Anna, Procopio, Antonio, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Karagkiozi, Efstathia, Athanasakis, George, Makaritsis, Kostantinos, Vadikolias, Kostantinos, Liantinioti, Chrysoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Colombo, Giovanna, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D’Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Baronello, Mario Maimone, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Gourbali, Vanessa, and Yaghi, Shadi

Published
2017
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6. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study

Author

Paciaroni, Maurizio, Inzitari, Domenico, Agnelli, Giancarlo, Caso, Valeria, Balucani, Clotilde, Grotta, James C., Sarraj, Amrou, Sung-Il, Sohn, Chamorro, Angel, Urra, Xabier, Leys, Didier, Henon, Hilde, Cordonnier, Charlotte, Dequatre, Nelly, Aguettaz, Pierre, Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D’Amore, Cataldo, Zini, Andrea, Vallone, Stefano, Dell’Acqua, Maria Luisa, Menetti, Federico, Nencini, Patrizia, Mangiafico, Salvatore, Barlinn, Kristian, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Bovi, Paolo, Cappellari, Manuel, Linfante, Italo, Dabus, Guilherme, Marcheselli, Simona, Pezzini, Alessandro, Padovani, Alessandro, Alexandrov, Andrei V., Shahripour, Reza Bavarsad, Sessa, Maria, Giacalone, Giacomo, Silvestrelli, Giorgio, Lanari, Alessia, Ciccone, Alfonso, De Vito, Alessandro, Azzini, Cristiano, Saletti, Andrea, Fainardi, Enrico, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Silvestrini, Mauro, Ferrarese, Carlo, Beretta, Simone, Tassi, Rossana, Martini, Giuseppe, Tsivgoulis, Georgios, Vasdekis, Spyros N., Consoli, Domenico, Baldi, Antonio, D’Anna, Sebastiano, Luda, Emilio, Varbella, Ferdinando, Galletti, Giampiero, Invernizzi, Paolo, Donati, Edoardo, De Lodovici, Maria Luisa, Bono, Giorgio, Corea, Francesco, Sette, Massimo Del, Monaco, Serena, Riva, Maurizio, Tassinari, Tiziana, Scoditti, Umberto, and Toni, Danilo

Published
2015
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7. Practical “1-2-3-4-Day” Rule for Starting Direct Oral Anticoagulants After Ischemic Stroke With Atrial Fibrillation: Combined Hospital-Based Cohort Study

Author

Kimura, Shunsuke, primary, Toyoda, Kazunori, additional, Yoshimura, Sohei, additional, Minematsu, Kazuo, additional, Yasaka, Masahiro, additional, Paciaroni, Maurizio, additional, Werring, David J., additional, Yamagami, Hiroshi, additional, Nagao, Takehiko, additional, Yoshimura, Shinichi, additional, Polymeris, Alexandros, additional, Zietz, Annaelle, additional, Engelter, Stefan T., additional, Kallmünzer, Bernd, additional, Cappellari, Manuel, additional, Chiba, Tetsuya, additional, Yoshimoto, Takeshi, additional, Shiozawa, Masayuki, additional, Kitazono, Takanari, additional, Koga, Masatoshi, additional, Todo, Kenichi, additional, Kimura, Kazumi, additional, Yagita, Yoshiki, additional, Furui, Eisuke, additional, Itabashi, Ryo, additional, Terasaki, Tadashi, additional, Shiokawa, Yoshiaki, additional, Hirano, Teruyuki, additional, Kamiyama, Kenji, additional, Nakagawara, Jyoji, additional, Takizawa, Shunya, additional, Homma, Kazunari, additional, Okuda, Satoshi, additional, Okada, Yasushi, additional, Tokunaga, Keisuke, additional, Kameda, Tomoaki, additional, Kario, Kazuomi, additional, Nagakane, Yoshinari, additional, Hasegawa, Yasuhiro, additional, Akiyama, Hisanao, additional, Shibuya, Satoshi, additional, Mochizuki, Hiroshi, additional, Ito, Yasuhiro, additional, Nakashima, Takahiro, additional, Matsuoka, Hideki, additional, Takamatsu, Kazuhiro, additional, Nishiyama, Kazutoshi, additional, Sato, Shoichiro, additional, Arihiro, Shoji, additional, Inoue, Manabu, additional, Takagi, Masahito, additional, Tanaka, Kanta, additional, Nagatsuka, Kazuyuki, additional, Yamaguchi, Takenori, additional, Hashimoto, Yoichiro, additional, Houkin, Kiyohiro, additional, Kitagawa, Kazuo, additional, Matsumoto, Masayasu, additional, Tanahashi, Norio, additional, Terayama, Yasuo, additional, Uchiyama, Shinichiro, additional, Mori, Etsuro, additional, Furukawa, Yutaka, additional, Kimura, Takeshi, additional, Kumon, Yoshiaki, additional, Nagata, Ken, additional, Nogawa, Shigeru, additional, Sakamoto, Tomohiro, additional, Hirai, Toshinori, additional, Kudo, Kohsuke, additional, Sasaki, Makoto, additional, Kobayashi, Shotai, additional, Hamasaki, Toshimitsu, additional, Giustozzi, Michela, additional, Acciarresi, Monica, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Bandini, Fabio, additional, Tsivgoulis, Georgios, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Zedde, Marialuisa, additional, Abdul-Rahim, Azmil H, additional, Lees, Kennedy R, additional, Alberti, Andrea, additional, Venti, Michele, additional, D’Amore, Cataldo, additional, Giulia Mosconi, Maria, additional, Anna Cimini, Ludovica, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Vannucchi, Vieri, additional, Sohn, Sung-Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, Karagkiozi, Efstathia, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrissoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Galati, Franco, additional, Sacco, Simona, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Lanari, Alessia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Ulivi, Leonardo, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Tassinari, Tiziana, additional, De Lodovici, Maria Luisa, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Baronello, Mario Maimone, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Barlinn, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, Masotti, Luca, additional, Parry-Jones, Adrian, additional, Patterson, Chris, additional, Price, Christopher, additional, Elmarimi, Abduelbaset, additional, Parry, Anthea, additional, Nallasivam, Arumug, additional, Mohd Nor, Azlisham, additional, Esis, Bernard, additional, Bruce, David, additional, Roffe, Christine, additional, Holmes, Clare, additional, Cohen, David, additional, Hargroves, David, additional, Mangion, David, additional, Chadha, Dinesh, additional, Vahidassr, Djamil, additional, Manawadu, Dulka, additional, Giallombardo, Elio, additional, Warburton, Elizabeth, additional, Flossman, Enrico, additional, Gunathilagan, Gunaratam, additional, Proschel, Harald, additional, Emsley, Hedley, additional, Anwar, Ijaz, additional, Okwera, James, additional, Putterill, Janet, additional, O’Connell, Janice, additional, Bamford, John, additional, Corrigan, John, additional, Scott, Jon, additional, Birns, Jonathan, additional, Kee, Karen, additional, Saastamoinen, Kari, additional, Pasco, Kath, additional, Dani, Krishna, additional, Sekaran, Lakshmanan, additional, Choy, Lillian, additional, Iveson, Liz, additional, Mamun, Maam, additional, Sajid, Mahmud, additional, Cooper, Martin, additional, Burn, Matthew, additional, Smith, Matthew, additional, Power, Michael, additional, Davis, Michelle, additional, Smyth, Nigel, additional, Veltkamp, Roland, additional, Sharma, Pankaj, additional, Guyler, Paul, additional, O’Mahony, Paul, additional, Wilkinson, Peter, additional, Datta, Prabel, additional, Aghoram, Prasanna, additional, Marsh, Rachel, additional, Luder, Robert, additional, Meenakishundaram, Sanjeevikumar, additional, Subramonian, Santhosh, additional, Leach, Simon, additional, Ispoglou, Sissi, additional, Andole, Sreeman, additional, England, Timothy, additional, Manoj, Aravindakshan, additional, Harrington, Frances, additional, Rehman, Habib, additional, Sword, Jane, additional, Staals, Julie, additional, Mahawish, Karim, additional, Harkness, Kirsty, additional, Shaw, Louise, additional, McCormich, Michael, additional, Sprigg, Nikola, additional, Mansoor, Syed, additional, Krishnamurthy, Vinodh, additional, Lyrer, Philippe A, additional, Bonati, Leo H, additional, Seiffge, David J, additional, Traenka, Christopher, additional, Peters, Nils, additional, De Marchis, Gian Marco, additional, Thilemann, Sebastian, additional, Avramiotis, Nikolaos S, additional, Gensicke, Henrik, additional, Hert, Lisa, additional, Wagner, Benjamin, additional, Schaub, Fabian, additional, Meya, Louisa, additional, Fladt, Joachim, additional, Dittrich, Tolga, additional, Fisch, Urs, additional, Bonetti, Bruno, additional, Tomelleri, Giampaolo, additional, Micheletti, Nicola, additional, Zivelonghi, Cecilia, additional, Emiliani, Andrea, additional, Macha, Kosmas, additional, Siedler, Gabriela, additional, Stoll, Svenja, additional, Wang, Ruihao, additional, Volbers, Bastian, additional, Schwab, Stefan, additional, Haupenthal, David, additional, and Gaßmann, Luise, additional

Published
2022
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8. Clinical Pregenetic Screening for Stroke Monogenic Diseases: Results From Lombardia GENS Registry

Author

Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond-Ginsbach, Caspar, and Candelise, Livia

Published
2016
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9. Early Recurrence and Cerebral Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Effect of Anticoagulation and Its Timing: The RAF Study

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Falocci, Nicola, Caso, Valeria, Becattini, Cecilia, Marcheselli, Simona, Rueckert, Christina, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Csiba, Laszló, Szabó, Lilla, Sohn, Sung-Il, Tassinari, Tiziana, Abdul-Rahim, Azmil H., Michel, Patrik, Cordier, Maria, Vanacker, Peter, Remillard, Suzette, Alberti, Andrea, Venti, Michele, Scoditti, Umberto, Denti, Licia, Orlandi, Giovanni, Chiti, Alberto, Gialdini, Gino, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Putaala, Jukka, Tatlisumak, Turgut, Masotti, Luca, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Martini, Giuseppe, Tsivgoulis, Georgios, Vadikolias, Kostantinos, Liantinioti, Chrissoula, Corea, Francesco, Del Sette, Massimo, Ageno, Walter, De Lodovici, Maria Luisa, Bono, Giorgio, Baldi, Antonio, D’Anna, Sebastiano, Sacco, Simona, Carolei, Antonio, Tiseo, Cindy, Acciarresi, Monica, D’Amore, Cataldo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Consoli, Domenico, Galati, Franco, Pieroni, Alessio, Toni, Danilo, Monaco, Serena, Baronello, Mario Maimone, Barlinn, Kristian, Pallesen, Lars-Peder, Kepplinger, Jessica, Bodechtel, Ulf, Gerber, Johannes, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Naveed, Mosconi, Maria Giulia, Bubba, Valentina, Silvestri, Ilenia, and Lees, Kennedy R.

Published
2015
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10. Timing of initiation of oral anticoagulants in patients with acute ischemic stroke and atrial\ud fibrillation comparing posterior and anterior circulation strokes

Author

Paciaroni, Maurizio, Agnelli, Giancarlo, Giustozzi, Michela, Tsivgoulis, Georgios, Yaghi, Shadi, MacGrory, Brian, Furie, Karen L., Tadi, Prasanna, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Dawson, Jesse, Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monica, D'Amore, Cataldo, Mosconi, Maria Guilia, Bognini, Valentina, Cappellari, Manuel, Rigatelli, Alberto, Bonetti, Bruno, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Turgut, Bandini, Fabio, Marcheselli, Simona, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Grifoni, Elisa, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Giuseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chrissoula, Palaiodimou, Lina, Mumoli, Nicola, Porta, Cesare, Galati, Franco, Sacco, Simona, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Silvestrelli, Giorgio, Ciccone, Alfonso, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Caselli, Maria Chiara, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Tassinari, Tiziana, De Lodovici, Maria Luisa, Rueckert, Christina, Baldi, Antonio, Toni, Danilo, Gentile, Luana, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Mannino, Marina, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Schirinzi, Erika, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Eskandari, Ashraf, Vanacker, Peter, Barlinn, Kristian, Barlinn, Jessica, Deleu, Dirk, Gourbali, Vanessa, and Caso, Valeria

Abstract

Background: The aim of this study in patients with acute posterior ischemic stroke (PS) and atrial fibrillation (AF) were to evaluate the risks of recurrent ischemic event and severe bleeding and these risks in relation with oral anticoagulant therapy (OAT) and its timing.\ud \ud Methods: Patients with PS were prospectively included; the outcome events of these patients were compared with those of patients with anterior stroke (AS) which were taken from previous registries. The primary outcome was the composite of: stroke recurrence, TIA, symptomatic systemic embolism, symptomatic cerebral bleeding and major extracranial bleeding occurring within 90 days from acute stroke.\ud \ud Results: A total of 2,470 patients were available for the analysis: 473 (19.1%) with PS and 1,997 (80.9%) AS. Over 90 days, 213 (8.6%) primary outcome events were recorded: 175 (8.7%) in patients with AS and 38 (8.0%) in those with PS. In patients who initiated OAT within 2 days, the primary outcome occurred in 5 out of 95 patients (5.3%) with PS compared to 21 out of 373 patients (4.3%) with AS (OR 1.07; 95% CI 0.39-2.94). In patients who initiated OAT between days 3 and 7, the primary outcome occurred in 3 out of 103 patients (2.9%) with PS compared to 26 out of 490 patients (5.3%) with AS (OR 0.54; 95% CI 0.16-1.80).\ud \ud Conclusions: Patients with posterior or anterior stroke and AF appear to have similar risks of\ud ischemic or hemorrhagic events at 90 days with no difference concerning the timing of initiation of OAT.

Published
2020

11. PREvention of VENous Thromboembolism in Hemorrhagic Stroke Patients – PREVENTIHS Study: A Randomized Controlled Trial and a Systematic Review and Meta-Analysis

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Alberti, Andrea, additional, Becattini, Cecilia, additional, Guercini, Francesco, additional, Martini, Giuseppe, additional, Tassi, Rossana, additional, Marotta, Giovanna, additional, Venti, Michele, additional, Acciarresi, Monica, additional, Mosconi, Maria Giulia, additional, Marcheselli, Simona, additional, Fratticci, Lara, additional, D’Amore, Cataldo, additional, Ageno, Walter, additional, Versino, Maurizio, additional, De Lodovici, Maria Luisa, additional, Carimati, Federico, additional, Pezzini, Alessandro, additional, Padovani, Alessandro, additional, Corea, Francesco, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Tassinari, Tiziana, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, and Caso, Valeria, additional

Published
2020
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12. Hemorrhagic transformation in acute ischemic stroke patients and atrial fibrillation: time to initiation of anticoagulants and outcome

Author

Paciaroni, Maurizio, Bandini, Fabio, Agnelli, Giancarlo, Tsivgoulis, Georgios, Yaghi, Shadi, Furie, Karen L., Tadi, Prasanna, Becattini, Cecilia, Zedde, Marialuisa, Abdul-Rahim, Azmil H., Lees, Kennedy R., Alberti, Andrea, Venti, Michele, Acciarresi, Monia, Volpi, Giacomo, Bovi, Paolo, Carletti, Monica, Rigatelli, Alberto, Cappellari, Manuel, Putaala, Jukka, Tomppo, Liisa, Tatlisumak, Targut, Marcheselli, Luca, Pezzini, Alessandro, Poli, Loris, Padovani, Alessandro, Masotti, Luca, Vannucchi, Vieri, Sohn, Sung-Il, Lorenzini, Gianni, Tassi, Rossana, Guideri, Francesca, Acampa, Maurizio, Martini, Guiseppe, Ntaios, George, Athanasakis, George, Makaritsis, Konstantinos, Karagkiozi, Efstathia, Vadikolias, Konstantinos, Liantinioti, Chirissoula, Chondrogianni, Maria, Mumoli, Nicola, Consoli, Domenico, Galati, Franco, Saxxo, Simona, Carolei, Antonio, Tiseo, Cindy, Corea, Francesco, Ageno, Walter, Bellesini, Marta, Colombo, Giovanna, Silvestrelli, Giorgio, Ciccone, Alfonso, Lanari, Alessia, Scoditti, Umberto, Denti, Licia, Mancuso, Michelangelo, Maccarrone, Miriam, Ulivi, Leonardo, Orlandi, Giovanni, Giannini, Nicola, Gialdini, Gino, Tassinari, Tiziana, De Lodovici, Maria Luisa, Bono, Giorgio, Rueckert, Christina, Baldi, Antonio, D'Anna, Sebastiano, Toni, Danilo, Letteri, Federica, Giuntini, Martina, Lotti, Enrico Maria, Flomin, Yuriy, Pieroni, Alessio, Kargiotis, Odysseas, Karapanayiotides, Theodore, Monaco, Serena, Maimone Baronello, Mario, Csiba, Laszló, Szabó, Lilla, Chiti, Alberto, Giorli, Elisa, Del Sette, Massimo, Imberti, Davide, Zabzuni, Dorjan, Doronin, Boris, Volodina, Vera, Michel, Patrik, Vanacker, Peter, Barlinn, Kristian, Pallesen, Lars-Peder, Barlinn, Jessica, Deleu, Dirk, Melikyan, Gayane, Ibrahim, Faisal, Akhtar, Navveed, Gourbali, Vanessa, and Caso, Valeria

Abstract

Background: \ud In patients with acute ischemic stroke and atrial fibrillation, early anticoagulation prevents ischemic recurrence but with the risk of hemorrhagic transformation (HT). The aims of this study were to evaluate in consecutive patients with acute stroke and atrial fibrillation (1) the incidence of early HT, (2) the time to initiation of anticoagulation in patients with HT, (3) the association of HT with ischemic recurrences, and (4) the association of HT with clinical outcome at 90 days.\ud \ud Methods and Results: \ud HT was diagnosed by a second brain computed tomographic scan performed 24 to 72 hours after stroke onset. The incidence of ischemic recurrences as well as mortality or disability (modified Rankin Scale scores >2) were evaluated at 90 days. Ischemic recurrences were the composite of ischemic stroke, transient ischemic attack, or systemic embolism. Among the 2183 patients included in the study, 241 (11.0%) had HT. Patients with and without HT initiated anticoagulant therapy after a mean 23.3 and 11.6 days, respectively, from index stroke. At 90 days, 4.6% (95% confidence interval, 2.3–8.0) of the patients with HT had ischemic recurrences compared with 4.9% (95% confidence interval, 4.0–6.0) of those without HT; 53.1% of patients with HT were deceased or disabled compared with 35.8% of those without HT. On multivariable analysis, HT was associated with mortality or disability (odds ratio, 1.71; 95% confidence interval, 1.24–2.35).\ud \ud Conclusions: \ud In patients with HT, anticoagulation was initiated about 12 days later than patients without HT. This delay was not associated with increased detection of ischemic recurrence. HT was associated with increased mortality or disability.

Published
2018

13. The role of clinical and neuroimaging features in the diagnosis of CADASIL

Author

Bersano, A, Bedini, G, Markus, H, Vitali, P, Colli-Tibaldi, E, Taroni, F, Gellera, C, Baratta, S, Mosca, L, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Lanfranconi, S, Mazucchelli, F, Zarcone, D, De Lodovici, M, Bono, G, Boncoraglio, G, Parati, E, Calloni, M, Perrone, P, Bordo, B, Motto, C, Agostoni, E, Pezzini, A, Padovani, A, Micieli, G, Cavallini, A, Molini, G, Sasanelli, F, Sessa, M, Comi, G, Checcarelli, N, Carmerlingo, M, Corato, M, Marcheselli, S, Fusi, L, Grampa, G, Uccellini, D, Beretta, S, Ferrarese, C, Incorvaia, B, Tadeo, C, Adobbati, L, Silani, V, Faragò, G, Trobia, N, Grond-Ginsbach, C, Candelise, L, Mazzucchelli, F, Guidotti, M, Riva, M, Iurlaro, S, Maria, B, Braga, M, Meola, G, Carpo, M, Camerlingo, M, Borutti, G, Delodovici, M, Verrengia, E, Tancredi, L, Terruzzi, A, Magoni, M, Del Zotto, E, Bassi, P, Lattuada, P, Ballabio, E, Gambaro, P, Corrà, B, Canavero, I, Arbustini, E, Grasso, M, Corti, S, Ronchi, D, Merlini, G, Obici, L, Bassi, M, Tagliavini, F, Ginsbach, C, Bersano, Anna, BEDINI, GLORIA, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, FERRARI, MAURIZIO, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, CORATO, MANUEL, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, Ginsbach, Caspar Grond, Bersano, A, Bedini, G, Markus, H, Vitali, P, Colli-Tibaldi, E, Taroni, F, Gellera, C, Baratta, S, Mosca, L, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Lanfranconi, S, Mazucchelli, F, Zarcone, D, De Lodovici, M, Bono, G, Boncoraglio, G, Parati, E, Calloni, M, Perrone, P, Bordo, B, Motto, C, Agostoni, E, Pezzini, A, Padovani, A, Micieli, G, Cavallini, A, Molini, G, Sasanelli, F, Sessa, M, Comi, G, Checcarelli, N, Carmerlingo, M, Corato, M, Marcheselli, S, Fusi, L, Grampa, G, Uccellini, D, Beretta, S, Ferrarese, C, Incorvaia, B, Tadeo, C, Adobbati, L, Silani, V, Faragò, G, Trobia, N, Grond-Ginsbach, C, Candelise, L, Mazzucchelli, F, Guidotti, M, Riva, M, Iurlaro, S, Maria, B, Braga, M, Meola, G, Carpo, M, Camerlingo, M, Borutti, G, Delodovici, M, Verrengia, E, Tancredi, L, Terruzzi, A, Magoni, M, Del Zotto, E, Bassi, P, Lattuada, P, Ballabio, E, Gambaro, P, Corrà, B, Canavero, I, Arbustini, E, Grasso, M, Corti, S, Ronchi, D, Merlini, G, Obici, L, Bassi, M, Tagliavini, F, Ginsbach, C, Bersano, Anna, BEDINI, GLORIA, Markus, Hugh Stephen, Vitali, Paolo, Colli-Tibaldi, Enrico, Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Mosca, Lorena, Carrera, Paola, FERRARI, MAURIZIO, Cereda, Cristina, Grieco, Gaetano, Lanfranconi, Silvia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, Sasanelli, Francesco, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Carmerlingo, Massimo, CORATO, MANUEL, Marcheselli, Simona, Fusi, Laura, Grampa, Giampiero, Uccellini, Davide, Beretta, Simone, Ferrarese, Carlo, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Adobbati, Laura, Silani, Vincenzo, Faragò, Giuseppe, Trobia, Nadia, Grond-Ginsbach, Caspar, Candelise, Livia, Mazzucchelli, Franca, Guidotti, Mario, Riva, Maurizio, Iurlaro, Simona, Maria, Bianca Bordo, Braga, Massimiliano, Meola, Giovanni, Carpo, Marinella, Camerlingo, Massimo, Borutti, Giuseppina, Delodovici, Marialuisa, Verrengia, Elena Pinuccia, Tancredi, Lucia, Terruzzi, Alessandro, Magoni, Mauro, Del Zotto, Elisabetta, Bassi, Pietro, Lattuada, Patrizia, Ballabio, Elena, Gambaro, Paola, Lanfranconi, Sivia, Corrà, Barbara, Canavero, Isabella, Arbustini, Eloisa, Grasso, Maurizia, Comi, Giacomo Pietro, Corti, Stefania, Ronchi, Dario, Merlini, Giampaolo, Obici, Laura, Bassi, Maria Teresa, Tagliavini, Fabrizio, and Ginsbach, Caspar Grond

Abstract

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL. Methods: Patients with lacunar stroke or TIA were included in the present study. For each patient, demographic and clinical data were collected. MRI images were centrally analysed for the presence of lacunar infarcts, microbleeds, temporal lobe involvement, global atrophy and white matter hyperintensities. Results: 128 patients (mean age 56.3 ± 12.4 years) were included. A NOTCH3 mutation was found in 12.5% of them. A family history of stroke, the presence of dementia and external capsule lesions on MRI were the only features significantly associated with the diagnosis of CADASIL. Although thalamic, temporal pole gliosis and severe white matter hyperintensities were less specific for CADASIL diagnosis, the combination of a number of these factors together with familial history for stroke result in a higher positive predictive value and specificity. Conclusions: A careful familial history collection and neuroradiological assessment can identify patients in whom NOTCH3 genetic testing has a higher yield.

Published
2018

14. Hemorrhagic Transformation in Patients With Acute Ischemic Stroke and Atrial Fibrillation: Time to Initiation of Oral Anticoagulant Therapy and Outcomes

Author

Paciaroni, Maurizio, primary, Bandini, Fabio, additional, Agnelli, Giancarlo, additional, Tsivgoulis, Georgios, additional, Yaghi, Shadi, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Becattini, Cecilia, additional, Zedde, Marialuisa, additional, Abdul‐Rahim, Azmil H., additional, Lees, Kennedy R., additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D'Amore, Cataldo, additional, Mosconi, Maria Giulia, additional, Cimini, Ludovica Anna, additional, Altavilla, Riccardo, additional, Volpi, Giacomo, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Cappellari, Manuel, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Sohn, Sung‐Il, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Ntaios, George, additional, Athanasakis, George, additional, Makaritsis, Konstantinos, additional, Karagkiozi, Efstathia, additional, Vadikolias, Konstantinos, additional, Liantinioti, Chrissoula, additional, Chondrogianni, Maria, additional, Mumoli, Nicola, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Silvestrelli, Giorgio, additional, Ciccone, Alfonso, additional, Lanari, Alessia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Ulivi, Leonardo, additional, Orlandi, Giovanni, additional, Giannini, Nicola, additional, Gialdini, Gino, additional, Tassinari, Tiziana, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Rueckert, Christina, additional, Baldi, Antonio, additional, D'Anna, Sebastiano, additional, Toni, Danilo, additional, Letteri, Federica, additional, Giuntini, Martina, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Pieroni, Alessio, additional, Kargiotis, Odysseas, additional, Karapanayiotides, Theodore, additional, Monaco, Serena, additional, Maimone Baronello, Mario, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Del Sette, Massimo, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Michel, Patrik, additional, Vanacker, Peter, additional, Barlinn, Kristian, additional, Pallesen, Lars‐Peder, additional, Barlinn, Jessica, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, Gourbali, Vanessa, additional, and Caso, Valeria, additional

Published
2018
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15. Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrysoula, additional, Chondrogianni, Maria, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Cappellari, Manuel, additional, Zedde, Marialuisa, additional, Ntaios, George, additional, Karagkiozi, Efstathia, additional, Athanasakis, George, additional, Makaritsis, Kostantinos, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, Putaala, Jukka, additional, Tomppo, Liisa, additional, Tatlisumak, Turgut, additional, Abdul‐Rahim, Azmil H., additional, Lees, Kennedy R., additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D'Amore, Cataldo, additional, Becattini, Cecilia, additional, Mosconi, Maria Giulia, additional, Cimini, Ludovica Anna, additional, Soloperto, Rossana, additional, Masotti, Luca, additional, Vannucchi, Vieri, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Acampa, Maurizio, additional, Martini, Giuseppe, additional, Sohn, Sung‐Il, additional, Marcheselli, Simona, additional, Mumoli, Nicola, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Furie, Karen L., additional, Tadi, Prasanna, additional, Yaghi, Shadi, additional, Toni, Danilo, additional, Letteri, Federica, additional, Tassinari, Tiziana, additional, Kargiotis, Odysseas, additional, Lotti, Enrico Maria, additional, Flomin, Yuriy, additional, Mancuso, Michelangelo, additional, Maccarrone, Miriam, additional, Giannini, Nicola, additional, Bandini, Fabio, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Consoli, Domenico, additional, Galati, Franco, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Gourbali, Vanessa, additional, Orlandi, Giovanni, additional, Giuntini, Martina, additional, Chiti, Alberto, additional, Giorli, Elisa, additional, Gialdini, Gino, additional, Corea, Francesco, additional, Ageno, Walter, additional, Bellesini, Marta, additional, Colombo, Giovanna, additional, Monaco, Serena, additional, Maimone Baronello, Mario, additional, Karapanayiotides, Theodore, additional, and Caso, Valeria, additional

Published
2017
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16. The role of clinical and neuroimaging features in the diagnosis of CADASIL.

Author

on behalf of Lombardia GENS-group, Bersano, Anna, Boncoraglio, Giorgio Battista, Parati, Eugenio Agostino, Trobia, Nadia, Mazucchelli, Franca, Zarcone, Davide, De Lodovici, Maria Luisa, Bono, Giorgio, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Motto, Cristina, Agostoni, Elio, Pezzini, Alessandro, Padovani, Alessandro, Micieli, Giuseppe, Cavallini, Anna, Molini, Graziella, and Sasanelli, Francesco

Subjects
CADASIL syndrome, PROGRESSIVE multifocal leukoencephalopathy, MONOGENIC functions, NOTCH genes, BRAIN imaging
Abstract

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common familial cerebral small vessel disease, caused by NOTCH3 gene mutations. The aim of our study was to identify clinical and neuroradiological features which would be useful in identifying which patients presenting with lacunar stroke and TIA are likely to have CADASIL.Methods: Patients with lacunar stroke or TIA were included in the present study. For each patient, demographic and clinical data were collected. MRI images were centrally analysed for the presence of lacunar infarcts, microbleeds, temporal lobe involvement, global atrophy and white matter hyperintensities.Results: 128 patients (mean age 56.3 ± 12.4 years) were included. A NOTCH3 mutation was found in 12.5% of them. A family history of stroke, the presence of dementia and external capsule lesions on MRI were the only features significantly associated with the diagnosis of CADASIL. Although thalamic, temporal pole gliosis and severe white matter hyperintensities were less specific for CADASIL diagnosis, the combination of a number of these factors together with familial history for stroke result in a higher positive predictive value and specificity.Conclusions: A careful familial history collection and neuroradiological assessment can identify patients in whom NOTCH3 genetic testing has a higher yield. [ABSTRACT FROM AUTHOR]

Published
2018
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17. Prognostic value of trans-thoracic echocardiography in patients with acute stroke and atrial fibrillation: findings from the RAF study

Author

Paciaroni, Maurizio, primary, Agnelli, Giancarlo, additional, Falocci, Nicola, additional, Caso, Valeria, additional, Becattini, Cecilia, additional, Marcheselli, Simona, additional, Rueckert, Christina, additional, Pezzini, Alessandro, additional, Poli, Loris, additional, Padovani, Alessandro, additional, Csiba, Laszló, additional, Szabó, Lilla, additional, Sohn, Sung-Il, additional, Tassinari, Tiziana, additional, Abdul-Rahim, Azmil H., additional, Michel, Patrik, additional, Cordier, Maria, additional, Vanacker, Peter, additional, Remillard, Suzette, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Mosconi, Maria Giulia, additional, Scoditti, Umberto, additional, Denti, Licia, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Bovi, Paolo, additional, Carletti, Monica, additional, Rigatelli, Alberto, additional, Putaala, Jukka, additional, Tatlisumak, Turgut, additional, Masotti, Luca, additional, Lorenzini, Gianni, additional, Tassi, Rossana, additional, Guideri, Francesca, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vadikolias, Kostantinos, additional, Liantinioti, Chrissoula, additional, Corea, Francesco, additional, Del Sette, Massimo, additional, Ageno, Walter, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Sacco, Simona, additional, Carolei, Antonio, additional, Tiseo, Cindy, additional, Imberti, Davide, additional, Zabzuni, Dorjan, additional, Doronin, Boris, additional, Volodina, Vera, additional, Consoli, Domenico, additional, Galati, Franco, additional, Pieroni, Alessio, additional, Toni, Danilo, additional, Monaco, Serena, additional, Baronello, Mario Maimone, additional, Barlinn, Kristian, additional, Pallesen, Lars-Peder, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Deleu, Dirk, additional, Melikyan, Gayane, additional, Ibrahim, Faisal, additional, Akhtar, Naveed, additional, and Lees, Kennedy R., additional

Published
2015
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18. Intravenous thrombolysis or endovascular therapy for acute ischemic stroke associated with cervical internal carotid artery occlusion: the ICARO-3 study

Author

Paciaroni, Maurizio, primary, Inzitari, Domenico, additional, Agnelli, Giancarlo, additional, Caso, Valeria, additional, Balucani, Clotilde, additional, Grotta, James C., additional, Sarraj, Amrou, additional, Sung-Il, Sohn, additional, Chamorro, Angel, additional, Urra, Xabier, additional, Leys, Didier, additional, Henon, Hilde, additional, Cordonnier, Charlotte, additional, Dequatre, Nelly, additional, Aguettaz, Pierre, additional, Alberti, Andrea, additional, Venti, Michele, additional, Acciarresi, Monica, additional, D’Amore, Cataldo, additional, Zini, Andrea, additional, Vallone, Stefano, additional, Dell’Acqua, Maria Luisa, additional, Menetti, Federico, additional, Nencini, Patrizia, additional, Mangiafico, Salvatore, additional, Barlinn, Kristian, additional, Kepplinger, Jessica, additional, Bodechtel, Ulf, additional, Gerber, Johannes, additional, Bovi, Paolo, additional, Cappellari, Manuel, additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Marcheselli, Simona, additional, Pezzini, Alessandro, additional, Padovani, Alessandro, additional, Alexandrov, Andrei V., additional, Shahripour, Reza Bavarsad, additional, Sessa, Maria, additional, Giacalone, Giacomo, additional, Silvestrelli, Giorgio, additional, Lanari, Alessia, additional, Ciccone, Alfonso, additional, De Vito, Alessandro, additional, Azzini, Cristiano, additional, Saletti, Andrea, additional, Fainardi, Enrico, additional, Orlandi, Giovanni, additional, Chiti, Alberto, additional, Gialdini, Gino, additional, Silvestrini, Mauro, additional, Ferrarese, Carlo, additional, Beretta, Simone, additional, Tassi, Rossana, additional, Martini, Giuseppe, additional, Tsivgoulis, Georgios, additional, Vasdekis, Spyros N., additional, Consoli, Domenico, additional, Baldi, Antonio, additional, D’Anna, Sebastiano, additional, Luda, Emilio, additional, Varbella, Ferdinando, additional, Galletti, Giampiero, additional, Invernizzi, Paolo, additional, Donati, Edoardo, additional, De Lodovici, Maria Luisa, additional, Bono, Giorgio, additional, Corea, Francesco, additional, Sette, Massimo Del, additional, Monaco, Serena, additional, Riva, Maurizio, additional, Tassinari, Tiziana, additional, Scoditti, Umberto, additional, and Toni, Danilo, additional

Published
2014
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19. Propensity Score-Based Analysis of Percutaneous Closure Versus Medical Therapy in Patients With Cryptogenic Stroke and Patent Foramen Ovale.

Author

Pezzini, Alessandro, Grassi, Mario, Lodigiani, Corrado, Patella, Rosalba, Gandolfo, Carlo, Zini, Andrea, De Lodovici, Maria Luisa, Paciaroni, Maurizio, Del Sette, Massimo, Toriello, Antonella, Musolino, Rossella, Calabrò, Rocco Salvatore, Bovi, Paolo, Adami, Alessandro, Silvestrelli, Giorgio, Sessa, Maria, Cavallini, Anna, Marcheselli, Simona, Bonifati, Domenico Marco, and Checcarelli, Nicoletta

Abstract

Background--We sought to compare the benefit of percutaneous closure to that of medical therapy alone for the secondary prevention of embolism in patients with patent foramen ovale (PFO) and otherwise unexplained ischemic stroke, in a propensity scored study. Methods and Results--Between 2000 and 2012, we selected consecutive first-ever ischemic stroke patients aged 18 to 45 years with PFO and no other cause of brain ischemia, as part of the IPSYS registry (Italian Project on Stroke in Young Adults), who underwent either percutaneous PFO closure or medical therapy for comparative analysis. Primary end point was a composite of ischemic stroke, transient ischemic attack, or peripheral embolism. Secondary end point was brain ischemia. Five hundred and twenty-one patients qualified for the analysis. The primary end point occurred in 15 patients treated with percutaneous PFO closure (7.3%) versus 33 patients medically treated (10.5%; hazard ratio, 0.72; 95% confidence interval, 0.39-1.32; P=0.285). The rates of the secondary end point brain ischemia were also similar in the 2 treatment groups (6.3% in the PFO closure group versus 10.2% in the medically treated group; hazard ratio, 0.64; 95% confidence interval, 0.33-1.21; P=0.168). Closure provided a benefit in patients aged 18 to 36 years (hazard ratio, 0.19; 95% confidence interval, 0.04-0.81; P=0.026) and in those with a substantial right-to-left shunt size (hazard ratio, 0.19; 95% confidence interval, 0.05-0.68; P=0.011). Conclusions--PFO closure seems as effective as medical therapy for secondary prevention of cryptogenic ischemic stroke. Whether device treatment might be more effective in selected cases, such as in patients younger than 37 years and in those with a substantial right-to-left shunt size, deserves further investigation. [ABSTRACT FROM AUTHOR]

Published
2016
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20. Clinical pregenetic screening for stroke monogenic diseases: Results from lombardia GENS registry

Author

Giorgio Bono, Eloisa Arbustini, Patrizia Perrone, Silvia Baratta, Graziella Molini, Elena Pinuccia Verrengia, Massimiliano Braga, Manuel Corato, Erminio Capitani, Gaetano S. Grieco, Pierluigi Baron, Giampaolo Merlini, Simona Marcheselli, Giuseppe Micieli, Nadia Trobia, Davide Uccellini, Anna Cavallini, Elio Agostoni, Mario Guidotti, Carlo Ferrarese, Alessandro Padovani, Laura Fusi, Caspar Grond-Ginsbach, Giacomo P. Comi, Silvia Lanfranconi, Marco Arnaboldi, Barbara Incorvaia, Livia Candelise, Maria Teresa Bassi, Cristina Motto, Paola Carrera, Lorena Mosca, Nicoletta Checcarelli, Lucia Tancredi, Alessando Pezzini, Hugh S. Markus, Laura Obici, Giancarlo Comi, Bianca Maria Bordo, Maria Luisa De Lodovici, Giorgio B. Boncoraglio, Davide Zarcone, Maurizia Grasso, Dario Ronchi, Maria Sessa, Francesca Mazucchelli, Maria Vittoria Calloni, Stefania Corti, Francesco Sasanelli, Paolo Vitali, Giampiero Grampa, C. Gellera, Maurizio Ferrari, Cristina Cereda, Antonio Colombo, Silvana Penco, Anna Bersano, Franco Taroni, Simone Beretta, Carlo Sebastiano Tadeo, Silvana Quaglini, Eugenio Parati, Bersano, A, Markus, H, Quaglini, S, Arbustini, E, Lanfranconi, S, Micieli, G, Boncoraglio, G, Taroni, F, Gellera, C, Baratta, S, Penco, S, Mosca, L, Grasso, M, Carrera, P, Ferrari, M, Cereda, C, Grieco, G, Corti, S, Ronchi, D, Bassi, M, Obici, L, Parati, E, Pezzini, A, De Lodovici, M, Verrengia, E, Bono, G, Mazucchelli, F, Zarcone, D, Calloni, M, Perrone, P, Bordo, B, Colombo, A, Padovani, A, Cavallini, A, Beretta, S, Ferrarese, C, Motto, C, Agostoni, E, Molini, G, Sasanelli, F, Corato, M, Marcheselli, S, Sessa, M, Comi, G, Checcarelli, N, Guidotti, M, Uccellini, D, Capitani, E, Tancredi, L, Arnaboldi, M, Incorvaia, B, Tadeo, C, Fusi, L, Grampa, G, Merlini, G, Trobia, N, Braga, M, Vitali, P, Baron, P, Grond Ginsbach, C, Candelise, L, Bersano, Anna, Markus, Hugh Stephen, Quaglini, Silvana, Arbustini, Eloisa, Lanfranconi, Silvia, Micieli, Giuseppe, Boncoraglio, Giorgio B., Taroni, Franco, Gellera, Cinzia, Baratta, Silvia, Penco, Silvana, Mosca, Lorena, Grasso, Maurizia, Carrera, Paola, Ferrari, Maurizio, Cereda, Cristina, Grieco, Gaetano, Corti, Stefania, Ronchi, Dario, Bassi, Maria Teresa, Obici, Laura, Parati, Eugenio A., Pezzini, Alessando, De Lodovici, Maria Luisa, Verrengia, Elena P., Bono, Giorgio, Mazucchelli, Francesca, Zarcone, Davide, Calloni, Maria Vittoria, Perrone, Patrizia, Bordo, Bianca Maria, Colombo, Antonio, Padovani, Alessandro, Cavallini, Anna, Beretta, Simone, Ferrarese, Carlo, Motto, Cristina, Agostoni, Elio, Molini, Graziella, Sasanelli, Francesco, Corato, Manuel, Marcheselli, Simona, Sessa, Maria, Comi, Giancarlo, Checcarelli, Nicoletta, Guidotti, Mario, Uccellini, Davide, Capitani, Erminio, Tancredi, Lucia, Arnaboldi, Marco, Incorvaia, Barbara, Tadeo, Carlo Sebastiano, Fusi, Laura, Grampa, Giampiero, Merlini, Giampaolo, Trobia, Nadia, Comi, Giacomo Pietro, Braga, Massimiliano, Vitali, Paolo, Baron, Pierluigi, Grond Ginsbach, Caspar, and Candelise, Livia

Subjects
Adult, Male, Mitochondrial encephalomyopathy, Pediatrics, medicine.medical_specialty, Pathology, DNA Mutational Analysis, CADASIL, Disease, 030204 cardiovascular system & hematology, MELAS syndrome, Leukoencephalopathy, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, genetics, Genetic Testing, Registries, Stroke, cerebral amyloid angiopathy, Aged, Genetic testing, Advanced and Specialized Nursing, Fabry disease, medicine.diagnostic_test, business.industry, cerebral amyloid angiopathy, familial, Marfan syndrome, stroke, Neurology (clinical), Cardiology and Cardiovascular Medicine, familial, Middle Aged, medicine.disease, Mutation, Female, genetic, business, 030217 neurology & neurosurgery
Abstract

Background and Purpose— Lombardia GENS is a multicentre prospective study aimed at diagnosing 5 single-gene disorders associated with stroke (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, Fabry disease, MELAS [mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes], hereditary cerebral amyloid angiopathy, and Marfan syndrome) by applying diagnostic algorithms specific for each clinically suspected disease Methods— We enrolled a consecutive series of patients with ischemic or hemorrhagic stroke or transient ischemic attack admitted in stroke units in the Lombardia region participating in the project. Patients were defined as probable when presenting with stroke or transient ischemic attack of unknown etiopathogenic causes, or in the presence of Results— In 209 patients (57.4±14.7 years), the application of the disease-specific algorithm identified 227 patients with possible monogenic disease. Genetic testing identified pathogenic mutations in 7% of these cases. Familial history of stroke was the only significant specific feature that distinguished mutated patients from nonmutated ones. The presence of cerebrovascular risk factors did not exclude a genetic disease. Conclusions— In patients prescreened using a clinical algorithm for monogenic disorders, we identified monogenic causes of events in 7% of patients in comparison to the 1% to 5% prevalence reported in previous series.

Published
2016

21. GEN-O-MA project: an Italian network studying clinical course and pathogenic pathways of moyamoya disease-study protocol and preliminary results.

Author

Bersano A, Bedini G, Nava S, Acerbi F, Sebastiano DR, Binelli S, Franceschetti S, Faragò G, Grisoli M, Gioppo A, Ferroli P, Bruzzone MG, Riva D, Ciceri E, Pantaleoni C, Saletti V, Esposito S, Nardocci N, Zibordi F, Caputi L, Marzoli SB, Zedde ML, Pavanello M, Raso A, Capra V, Pantoni L, Sarti C, Pezzini A, Caria F, Dell' Acqua ML, Zini A, Baracchini C, Farina F, Sanguigni S, De Lodovici ML, Bono G, Capone F, Di Lazzaro V, Lanfranconi S, Toscano M, Di Piero V, Sacco S, Carolei A, Toni D, Paciaroni M, Caso V, Perrone P, Calloni MV, Romani A, Cenzato M, Fratianni A, Ciusani E, Prontera P, Lasserve ET, Blecharz K, Vajkoczy P, and Parati EA

Subjects
Adolescent, Adult, Aged, Brain Ischemia complications, Child, Child, Preschool, Disease Progression, Female, Humans, Infant, Infant, Newborn, Italy, Male, Middle Aged, Phenotype, Retrospective Studies, Young Adult, Community Networks statistics & numerical data, Moyamoya Disease diagnostic imaging, Moyamoya Disease epidemiology, Moyamoya Disease genetics, Neuroimaging, Stroke complications
Abstract

Background: GENetics of mOyaMoyA (GEN-O-MA) project is a multicenter observational study implemented in Italy aimed at creating a network of centers involved in moyamoya angiopathy (MA) care and research and at collecting a large series and bio-repository of MA patients, finally aimed at describing the disease phenotype and clinical course as well as at identifying biological or cellular markers for disease progression. The present paper resumes the most important study methodological issues and preliminary results., Methods: Nineteen centers are participating to the study. Patients with both bilateral and unilateral radiologically defined MA are included in the study. For each patient, detailed demographic and clinical as well as neuroimaging data are being collected. When available, biological samples (blood, DNA, CSF, middle cerebral artery samples) are being also collected for biological and cellular studies., Results: Ninety-eight patients (age of onset mean ± SD 35.5 ± 19.6 years; 68.4% females) have been collected so far. 65.3% of patients presented ischemic (50%) and haemorrhagic (15.3%) stroke. A higher female predominance concomitantly with a similar age of onset and clinical features to what was reported in previous studies on Western patients has been confirmed., Conclusion: An accurate and detailed clinical and neuroimaging classification represents the best strategy to provide the characterization of the disease phenotype and clinical course. The collection of a large number of biological samples will permit the identification of biological markers and genetic factors associated with the disease susceptibility in Italy.

Published
2019
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