23 results on '"De Luca AM"'
Search Results
2. A novel nonsense variation in the albumin gene (c.1309 A>T) causing analbuminaemia.
- Author
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Caridi, G, Farokhnia, A, Lugani, F, de Luca, AM, Campagnoli, M, Galliano, M, Schröpfer, D, and Minchiotti, L
- Published
- 2021
- Full Text
- View/download PDF
3. Influence of chronic Naltrexone treatment on growth hormone and insulin secretion in obese subjects
- Author
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De Marinis, L, primary, Mancini, A, additional, Valle, D, additional, Bianchi, A, additional, De Luca, AM, additional, Fulghesu, AM, additional, Villa, P, additional, Mancuso, S, additional, and Lanzone, A, additional
- Published
- 1997
- Full Text
- View/download PDF
4. Acute non-lymphocytic leukemia following Hodgkin's disease. Clinical, biological and cytogenetic aspect of three cases
- Author
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Papa, G, Alimena, Giuliana, Annino, L, Anselmo, Anna Paola, Ciccone, F, De Luca AM, Granati, L, Petti, N, and Mandelli, Franco
- Published
- 1979
5. La progettazione del sé professionale alla fine dell’adolescenza
- Author
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Di Vita, A, Zanniello, G, Lucisano, P, Zanniello, G, Giuliani, A, Sposetti, P, Szpunar, G, Fioretti, F, Di Vita, A, De Santis, M, Crispoldi, S, Biasi, V, Caggiano, V, Ciraci, AM, Moretti, G, Morini, AL, La Rocca, C, Casale, E, Zollo, I, Sibilio, M, Nuzzaci, A, Marcozzi, I, Calenda, M, Ferrantino, C, Petolicchio, A, Milito, F, Rubat du Mérac, E, De Santis, C, Marco De Luca, A, Tammaro, R, Tiso, M, Montalbetti, K, Orizio, E, Kasa, P, de Luca, AM, Vegliante, R, Miranda, S, De Angelis, M, Santonicola, M, Marzano, A, Lisimberti, C, Rossi, L, Leone, T, Salerni, A, Castellana, G, Margottini, M, Rossi, F, De Carlo, F, Poce, A, Amenduni, F, Re, MR, La Marca, A, Di Martino, V, Gülbay, E, Mitrovic, S, Silva, L, Batini, F, Bartolucci, M, Maccario, D, Menichetti, L, Cavicchioli, C, and Consoli, G
- Subjects
strategia di orientamento ,progetto di vita professionale ,competenze trasversali ,guidance strategy ,transversal skills ,high school-university ,professional life project ,liceo-università ,Settore M-PED/03 - Didattica E Pedagogia Speciale - Abstract
Si è conclusa il 15 maggio 2019 la prima parte di una ricerca- intervento ispirata alla teoria del pensiero narrativo, ai principi dell’educational counseling e della didattica orientativa. Duran- te l’anno scolastico 2018-2019, 93 studenti (50 femmine e 43 maschi) del quarto anno di cinque licei di Palermo hanno partecipato a un’iniziativa sperimentale in cui scuola e università hanno collaborato con un duplice scopo: ridurre negli studenti il gap rilevato tra le conoscenze in uscita dal liceo e quelle richieste all’inizio dei corsi universitari e potenziare in loro la capacità di formulare il proprio progetto di vita professionale. È stata sperimentata l’azione congiunta di tre tipi di interventi: la scrittura espressiva per prefigurare il proprio futuro formativo-professionale, il colloquio di orientamento per esercitare la propria capacità decisionale e la co-conduzione di laboratori pomeridiani da parte di un docente universitario e di un docente di liceo della stessa area disciplinare. Si è voluto verificare fino a che punto la partecipazione all’iniziativa facilitasse lo sviluppo negli studenti liceali di tre competenze trasversali che incidono significativamente nel processo di maturazione della scelta formativo-professionale: l’immagine adeguata del «sé» attuale, l’autoefficacia percepita e la capacità decisionale. La valutazione iniziale del grado di sviluppo delle tre competenze che si intendeva promuovere è stata effettuata nel novembre del 2018 e quella finale nel mese di maggio del 2019; inoltre, una valutazione intermedia dell’immagine del «sé» attuale è stata effettuata anche a gennaio e a marzo del 2019. Per verificare la significatività delle differenze «pre-post» è stato usato il test statistico t. Le differenze risultano significative per il costrutto dell’autoefficacia (p=0,004) e per la dimensione «energia» (p=0,0002) dell’immagine del «sé» attuale. Dopo lo svolgimento delle attività gli alunni si percepiscono più capaci di affrontare i compiti scolastici. The first part of an intervention-research, inspired on the the- ory of narrative thought, the principles of educational coun- seling and guidance in teaching, was concluded on May 15th 2019. During the school year 2018-2019, students (n=93, 50 females and 43 males) attending the fourth year of high school in Palermo, participated in an experimental initiative in which schools and university collaborated with a dual purpose: 1) to reduce in the students the gap between the acquired knowl- edges at the end of high school courses and those required at the beginning of university courses and, 2) to strengthen the ability to formulate their own professional life project. The joint action of three types of interventions was experimented: expressive writing to prefigure one’s own educational-profes- sional future, the guidance interview to exercise one’s decision- making skill and the conduction of afternoon teaching work- shops held by a university professor and a high school teacher from the same discipline. It was intended to verify if the par- ticipation in this initiative would facilitate, in high school stu- dents, the development of three transversal skills that signifi- cantly affect the process of maturation of the educational-pro- fessional choice: the adequate image of the current «oneself», the perceived self-efficacy and the decision-making skill. The initial assessment of the development degree of the three skills that were intended to promote, was carried out firstly, in November 2018 and lastly but not least, in May 2019. More- over, an intermediate assessment of the current «oneself» im- age was carried out in January and March 2019. The statistical t-test was used to verify the significance of the «pre-post» dif- ferences. There is, not only a significant difference in the con- struct of self-efficacy (p = 0.004) but also in the «energy» di- mension of the current «oneself» image (p = 0.0002). After carrying out the activities, the students perceive themselves as more able of dealing with school tasks.
- Published
- 2020
6. Tipologie di ricerca didattica in Italia (2016-2018)
- Author
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Giuseppe Zanniello, Lucisano, P, Zanniello, G, Giuliani, A, Sposetti, P, Szpunar, G, Fioretti, F, Di Vita, A, De Santis, M, Crispoldi, S, Biasi, V, Caggiano, V, Ciraci, AM, Moretti, G, Morini, AL, La Rocca, C, Casale, E, Zollo, I, Sibilio, M, Nuzzaci, A, Marcozzi, I, Calenda, M, Ferrantino, C, Petolicchio, A, Milito, F, Rubat du Mérac, E, De Santis, C, Marco De Luca, A, Tammaro, R, Tiso, M, Montalbetti, K, Orizio, E, Kasa, P, de Luca, AM, Vegliante, R, Miranda, S, De Angelis, M, Santonicola, M, Marzano, A, Lisimberti, C, Rossi, L, Leone, T, Salerni, A, Castellana, G, Margottini, M, Rossi, F, De Carlo, F, Poce, A, Amenduni, F, Re, MR, La Marca, A, Di Martino, V, Gülbay, E, Mitrovic, S, Silva, L, Batini, F, Bartolucci, M, Maccario, D, Menichetti, L, Cavicchioli, C, Consoli, G, and Giuseppe Zanniello
- Subjects
teaching research methods, teaching research topics, perspectives of didactic research ,metodi della ricerca didattica, temi della ricerca didattica, prospettive della ricerca didattica ,Settore M-PED/03 - Didattica E Pedagogia Speciale - Abstract
In Italia, nel triennio 2016-2018, si è fatta ricerca didattica sul processo di insegnamento- apprendimento in tre modi: l’analisi fenomenologica e l’osservazione della dimensione quantitativa della realtà educativa; la costruzione di categorie interpretative del collegamento delle azioni dei docenti con i cambiamenti osservati nei discenti; la formulazione di principi e orientamenti per la pratica didattica. I temi delle ricerche didattiche svolte nel periodo sono raggruppabili in quattordici aree: la didattica universitaria, la didattica inclusiva, la didattica interculturale, la didattica orientativa, la didattica metacognitiva, la raccolta e l’analisi di pratiche didattiche, le nuove tecnologie per l’insegnamento e l’apprendimento, la valutazione degli alunni, la valutazione degli insegnanti e degli istituti scolastici, la didattica personalizzata, la progettazione degli interventi formativi, la formazione iniziale degli insegnanti, i servizi educativi per l’infanzia, le didattiche delle discipline. Per la cumulabilità dei risultati delle ricerche didattiche è avvertita l’esigenza di procedure metodologiche condivise dall’intera comunità scientifica. In the 2016-2018 three-year period, the Italian teaching research was carried out on the teaching- learning process in three ways: the phenomenological analysis and the observation of the quantitative dimension of the educational reality; the construction of categories to interpret the connections between teachers' actions and the changes observed in the learners; the formulation of principles and guidelines for the teaching practice. The themes of the teaching research carried out in the period can be grouped into fourteen areas: university teaching, inclusive teaching, intercultural teaching, orientation teaching, metacognitive teaching, the collection and analysis of teaching practices, new technologies for teaching and learning, pupils' evaluation, teachers' and schools' evaluation, personalized teaching, planning of training interventions, initial teacher training, educational services for children, didactics of the disciplines. Because of the accumulation of the results of educational research, there is a need for sharing methodological procedures within the entire scientific community.
- Published
- 2020
7. [The identification of the criteria of malignancy and the tissue characterization of expansive processes in periskeletal soft tissues. The current role of magnetic resonance]
- Author
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Cappabianca S, Am, Luca, Fm, Iscaro, Sirignano C, Cantarella R, Del Vecchio W, Roberto Grassi, Cappabianca, Salvatore, DE LUCA, Am, Iscaro, Fm, Sirignano, C, Cantarella, R, DEL VECCHIO, W, and Grassi, Roberto
- Subjects
Adult ,Diagnosis, Differential ,Male ,Adolescent ,Child, Preschool ,Humans ,Female ,Soft Tissue Neoplasms ,Middle Aged ,Child ,Magnetic Resonance Imaging ,Sensitivity and Specificity - Abstract
INTRODUCTION: Expansive masses arising from periskeletal soft tissues are a frequent challenge for the imaging specialist. Lesion diagnosis and characterization, and the assessment of benign/malignant nature are very important factors for treatment planning. We investigated MR capabilities in distinguishing benign from malignant masses and for histopathologic lesion characterization, also in the light of the latest most authoritative literature reports. MATERIAL AND METHODS: February 1995 to November 1997, we examined 237 patients with known space-occupying lesions arising from periskeletal soft tissues. T1- and PD/T2-weighted SE images were acquired on the most suitable planes. The findings were independently evaluated by two groups of radiologists who were asked a benignity/malignancy judgment based on specific morphological criteria and then a presumptive histopathologic characterization. The results were then compared with pathologic findings. RESULTS: We had high agreement rates for benignity/malignancy judgements, with only < or = 3.8% error rates. In contrast, rates were quite variable for histopathologic characterization and differed greatly by lesion type. The lesions, defined as malignant, could not be characterized histologically in approximately 18% of cases by both groups. DISCUSSION AND CONCLUSIONS: Our results, which are in substantial agreement with the recent authoritative literature, confirm MRI as an extremely reliable tool for distinguishing benign from malignant expansive masses arising from periskeletal soft tissues. On the contrary, MRI exhibits good specificity in histopathologic characterization only for the masses with such development as to permit identification of the anatomical compartment of origin, which are usually benign, as well as the masses with typical or pathognomonic tissue signal.
- Published
- 1999
8. Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections.
- Author
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Granata G, Petrosillo N, Adamoli L, Bartoletti M, Bartoloni A, Basile G, Bassetti M, Bonfanti P, Borromeo R, Ceccarelli G, De Luca AM, Di Bella S, Fossati S, Franceschini E, Gentile I, Giacobbe DR, Giacometti E, Ingrassia F, Lagi F, Lobreglio G, Lombardi A, Lupo LI, Luzzati R, Maraolo AE, Mikulska M, Mondelli MU, Mularoni A, Mussini C, Oliva A, Pandolfo A, Rogati C, Trapani FF, Venditti M, Viale P, Caraffa E, Cataldo MA, and On Behalf Of The ReCloDi Recurrence Of Clostridioides Difficile Infection Study Group
- Abstract
Background: Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate., Methods: We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI., Results: Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7; 95% CI: 1.1-2.7, p = 0.03)., Conclusion: Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.
- Published
- 2021
- Full Text
- View/download PDF
9. Effect of folic acid and vitamin C supplementation on folate status and homocysteine level: a randomised controlled trial in Italian smoker-blood donors.
- Author
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Cafolla A, Dragoni F, Girelli G, Tosti ME, Costante A, De Luca AM, Funaro D, and Scott CS
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- Adult, Blood Donors, Female, Folic Acid analysis, Homocysteine metabolism, Humans, Italy, Male, Middle Aged, Probability, Prospective Studies, Reference Values, Sensitivity and Specificity, Smoking, Statistics, Nonparametric, Ascorbic Acid administration & dosage, Dietary Supplements, Erythrocytes metabolism, Folic Acid administration & dosage, Homocysteine blood
- Abstract
Background: This trial sought to examine the effects of high dosage of folic acid and vitamin C supplementation on red blood cell folate (RCF), serum folate (SF) and homocysteine (Hcy) levels in subjects who smoke more than 15 cigarettes per day., Methods: A prospective study of 100 Italian repeat blood donors was undertaken to measure RCF, SF and Hcy levels before and after 45 days of vitamin supplementation. All subjects were randomised into four groups: [A] folic acid (FA) 5 mg/day, [B] vitamin C 500 mg/day, [C] FA 5 mg/day plus vitamin C 500 mg/day [D] no supplementation., Results: Before supplementation the median RCF, SF and Hcy levels were similar in the four groups; 32 (40%) subjects had an RCF level below 340 nmol/l, 15 (18.8%) had an SF level below 6.8 nmol/l and 21 (26.3%) had an Hcy level above 16 micromol/l. After 45 days the median RCF and SF levels were significantly (P<0.01) increased in all supplemented subjects. The median Hcy level was significantly (P=0.008) reduced in subjects supplemented with FA and significantly (P=0.01) increased in those supplemented with vitamin C alone., Conclusion: The supplementation with 5 FA mg/day is able to increase significantly both RCF and SF levels and reduce Hcy level in Italian smoker-blood donors.
- Published
- 2002
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10. Carboxylic acids and skeletal muscle chloride channel conductance: effects on the biological activity induced by the introduction of methyl groups on the aromatic ring of chiral alpha-(4-chloro-phenoxy)alkanoic acids.
- Author
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Ferorelli S, Loiodice F, Tortorella V, Conte-Camerino D, and De Luca AM
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- Animals, Carboxylic Acids pharmacology, Circular Dichroism, Hydrolysis, In Vitro Techniques, Male, Mass Spectrometry, Muscle, Skeletal drug effects, Rats, Spectrophotometry, Infrared, Stereoisomerism, Alkanes chemical synthesis, Alkanes pharmacology, Carboxylic Acids chemical synthesis, Chloride Channels antagonists & inhibitors, Muscle, Skeletal metabolism
- Abstract
One or two methyl groups have been introduced on the aromatic ring of two chiral clofibric acid analogs, 2-(4-chloro-phenoxy)propanoic and 2-(4-chloro-phenoxy)butanoic acids. The biological activity of the derivatives obtained (3-6) has been evaluated on the skeletal muscle chloride conductance (gCl). The results confirm the hypothesis of two different sites modulating chloride channel function, an excitatory site that increases channel activity and an inhibitory site that produces a channel block. In fact, this chemical modification strongly reduces the blocking activity of the (R)- and (S)-enantiomers in comparison with the parent compounds, but does not markedly affect the ability of the (R)-enantiomers to increase chloride channel conductance.
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- 2001
- Full Text
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11. Naloxone effects on post-prandial glucose, insulin and C-peptide levels in obese subjects.
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De Marinis L, Mancini A, De Luca AM, Fiumara C, Zuppi P, Sammartano L, and Valle D
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- Adult, Analysis of Variance, C-Peptide drug effects, Diabetes Mellitus, Type 2 drug therapy, Female, Humans, Infusions, Intravenous, Middle Aged, Obesity drug therapy, Blood Glucose metabolism, C-Peptide blood, Diabetes Mellitus, Type 2 blood, Insulin blood, Naloxone pharmacology, Obesity blood
- Abstract
In order to investigate the relationships between glucose metabolism, insulin secretion and endogenous opioids in obese patients, we have studied the effects of a naloxone infusion on insulin and C-peptide release after a normal meal (800 kcal) eaten at 12.00 hr in 16 obese women, aged 20-61 yr, with a BMI ranging from 25 to 37.2 kg/m2, with normal glucose tolerance (Group 1) and with NIDDM (Group 2). Naloxone was administered in a bolus of 1.6 mg i.v., followed by a continuous infusion of 4 mg in 2 hr starting immediately after feeding. In Group 1 naloxone infusion significantly increased the glucose levels, but insulin secretion was unaffected. In Group 2, naloxone infusion failed to modify significantly the postprandial levels of glucose, insulin and C-peptide. Therefore, in our study naloxone infusion seems to have beta-endorphin-like effects in non-diabetic obese subjects by increasing their glycemic levels, with no evidence of expected insulin decrease. In diabetic obese patients we observed a trend towards decrease in glycemic values during naloxone infusion, as expected, due to insulin plasma levels increase. By these data we can hypothesise a complex regulatory role of opioids in metabolic balance in obesity. In diabetic patients, naloxone can improve the surviving insulin secretion with better glucose tolerance. In non-diabetic subjects naloxone exerts its effects, probably, on peripheral organs.
- Published
- 1993
12. Treatment of acute nonlymphoid leukaemia with five different schedules including cytosine arabinoside and 6-thioguanine.
- Author
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Mandelli F, Amadori S, De Luca AM, Deriu L, De Rossi G, Isacchi G, Mariani G, Monarca B, Papa G, and Di Giovanni F
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- Adolescent, Adult, Aged, Antineoplastic Agents administration & dosage, Asparaginase therapeutic use, Child, Child, Preschool, Daunorubicin therapeutic use, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Vincristine therapeutic use, Antineoplastic Agents therapeutic use, Cytarabine therapeutic use, Leukemia drug therapy, Thioguanine therapeutic use
- Published
- 1977
13. Treatment of MOPP-resistant Hodgkin's disease with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD).
- Author
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Papa G, Mandelli F, Anselmo AP, De Luca AM, Maurizienrici R, Mauro F, Testi AM, Amadori S, and Biagini C
- Subjects
- Adolescent, Adult, Bleomycin therapeutic use, Child, Dacarbazine therapeutic use, Doxorubicin therapeutic use, Drug Resistance, Drug Therapy, Combination, Female, Hodgkin Disease mortality, Humans, Male, Mechlorethamine administration & dosage, Middle Aged, Prednisone administration & dosage, Procarbazine administration & dosage, Vinblastine, Vincristine administration & dosage, Vincristine therapeutic use, Antineoplastic Agents administration & dosage, Antineoplastic Combined Chemotherapy Protocols, Hodgkin Disease drug therapy
- Published
- 1982
- Full Text
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14. A new desk-top artificial pancreas (Betalike) utilizing extracorporeal hemofiltration: realization and clinical trials.
- Author
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Bernardi L, Bombardieri G, Bellini V, De Luca AM, Rossi L, Palazzo P, Fontana E, Miracoli L, and Porro GP
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- Blood Glucose metabolism, Clinical Trials as Topic, Diabetes Mellitus blood, Diabetes Mellitus drug therapy, Humans, Hemofiltration instrumentation, Insulin Infusion Systems
- Abstract
We present in this work a new artificial endocrine pancreas (BETALIKE), smaller than the available ones, transportable and fully automated. In the clinical trials performed this device showed good blood glucose controls and glycemic measurements were highly correlated with other automatic analyzer assays. No side effect was reported.
- Published
- 1985
15. Adult acute lymphoblastic leukemia: description and analysis of long-term survivors. A retrospective study.
- Author
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Giona F, Mazzucconi MG, Aloe Spiriti MA, Defazio D, De Luca AM, Ferrazza G, Martinelli E, and Mandelli F
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- Adolescent, Adult, Female, Humans, Male, Middle Aged, Retrospective Studies, Survival Rate, Precursor Cell Lymphoblastic Leukemia-Lymphoma mortality
- Abstract
This retrospective study, including 118 patients with acute lymphoblastic leukemia (ALL) aged greater than 15 years, with a minimum follow-up of 6 years, was aimed at defining potentially "cured" adults with ALL. At present, 21 out of 92 patients who achieved complete remission (CR) are long survivors: 16 in first CR, off-therapy; 4 in 2nd CR (3 off-therapy); 1 in 3rd CR, on treatment. On the basis of available data, we tried to identify factors at diagnosis which might predict long-term survival: white blood cell (WBC) count on admission was the only significant prognostic factor for overall survival (p = 0.0002) and first CR duration (p = 0.0005). The survival hazard rate (risk of death from acute leukemia per day) reaches 0 between 8 and 9 years from diagnosis. From our data we can identify two groups of ALL long-term survivors: the first includes 16 patients in 1st continuous CR (CCR), 12 of whom in CCR for over 8 years may be considered "cured"; the second group comprises 5 patients, relapsing once or twice, alive in 2nd or 3rd CR.
- Published
- 1989
16. Acute non lymphoid leukaemia following Hodgkin's disease. Clinical, biological and cytogenetic aspects of 3 cases.
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Papa G, Alimena G, Annino L, Anselmo AP, Ciccone F, De Luca AM, Granati L, Petti N, and Mandelli F
- Subjects
- Acute Disease, Adult, Bone Marrow pathology, Chromosome Aberrations, Female, Follow-Up Studies, Hodgkin Disease genetics, Humans, Karyotyping, Leukemia, Erythroblastic, Acute genetics, Leukemia, Myeloid genetics, Leukemia, Myeloid, Acute etiology, Leukemia, Myeloid, Acute genetics, Male, Hodgkin Disease complications, Leukemia, Erythroblastic, Acute etiology, Leukemia, Myeloid etiology
- Abstract
In a groups of 254 patients treated for Hodgkin's disease with a follow up period of minimum 2 years, 3 cases of acute non lymphoid leukaemia (ANLL) were observed: erythroleukaemia, myelomonocytic and myeloblastic leukaemia, respectively. The crude incidence of leukaemia in all patients was 0.0128 and patient year risk was estimated to be 0.003652. All 3 patients had received radiation therapy and chemotherapy. In all cases of haemopoietic dysplasia preceded ANLL. Bone marrow chromosome investigations showed an abnormal karyotype in all patients: chromosomal changes were present in 100% of cells and revealed a non-random distribution, the most frequent involvement being clustered to chromosomes nos 11, 17 and 21. Hypodiploidy was prevalent and multiple structural rearrangements, such as markers, rings and minutes, were present in a high percentage of cells. Other changes involved chromosomes nos 5, 7 and 14. Our results are compared with other previously reported cases and possible pathogenetic implications are discussed.
- Published
- 1979
- Full Text
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17. Combination chemotherapy of unfavourable prognosis non-Hodgkin's lymphomas (NHL). A retrospective study of 53 cases.
- Author
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Mandelli F, Biagini C, Baroni CD, Bosman C, Alimena G, Anselmo AP, De Luca AM, Maurizi Enrici R, Petti N, Amadori S, and Papa G
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Lymphoma pathology, Lymphoma, Large B-Cell, Diffuse drug therapy, Lymphoma, Non-Hodgkin drug therapy, Male, Middle Aged, Neoplasm Staging, Prognosis, Antineoplastic Agents administration & dosage, Lymphoma drug therapy
- Published
- 1981
18. Bone marrow involvement at onset of Hodgkin's disease.
- Author
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Cimino G, Anselmo AP, De Luca AM, Fidani P, Mauro F, Marzullo A, Maurizi Enrici R, and Papa G
- Subjects
- Adult, Antineoplastic Agents therapeutic use, Blood Cell Count, Female, Hodgkin Disease drug therapy, Hodgkin Disease mortality, Humans, Male, Middle Aged, Bone Marrow pathology, Bone Marrow Diseases pathology, Hodgkin Disease pathology
- Abstract
Bilateral trephine bone marrow biopsies of 370 patients with Hodgkin's disease first seen at the Institute of Hematology, University of Rome, between 1970 and 1981, revealed tumor involvement of the bone marrow in 18 cases. The histologic type was mixed cellularity in 7 cases, lymphocytic depletion in 4 cases, nodular sclerosis in 4 cases, and lymphocytic prevalence in 1 case. Anemia with less than 10 g/dl of hemoglobin was observed in 5 patients; white blood cells were less than 4.0 X 10(9)/liter in 2 patients; platelets were less than 12.0 X 10(9)/liter in 1 case; a pancytopenic condition was observed in only 1 case. B symptoms were present in 14 of the 18 patients. All patients who underwent laparosplenectomy presented spleen involvement, 4 also had liver involvement. All patients were treated with chemotherapy; MOPP regimen was employed in 11 cases, ABVD in 5 patients, and PROVECIP in 1 case. Of the 13 patients evaluable for therapeutic response, 11 achieved complete remission, with a median actuarial relapse-free survival of 15 months. The actuarial survival curve showed that 50% of all patients are projected alive at 47 months with a follow-up ranging from 1 to 109 months.
- Published
- 1983
- Full Text
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19. The effect of breathing 100% oxygen on lung response to radiation in mice.
- Author
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Travis EL and De Luca AM
- Subjects
- Animals, Dose-Response Relationship, Radiation, Male, Mice, Misonidazole pharmacology, Time Factors, Lung radiation effects, Oxygen pharmacology, Radiation Injuries, Experimental pathology, Radiation-Sensitizing Agents
- Abstract
The response of the lung after single doses of radiation was measured in mice breathing air, or 100% oxygen, or in air-breathing mice given the hypoxic cell sensitizer misonidazole 30 min before irradiation. There was a clear enhancement of only the pneumonitis response in the mice breathing oxygen when breathing rate or lethality was used to assess injury. Less enhancement of the late fibrotic reaction was observed in these animals. No enhancement of either phase of lung response was observed in the misonidazole-treated mice. Dose reduction factors (DRF) were estimated from these data and used to calculate oxygen concentration in the lung, giving values ranging between 187 and 250 micron oxygen.
- Published
- 1985
- Full Text
- View/download PDF
20. Treatment of non Hodgkin's lymphoma with "PROVECIP" (procarbazine, vinblastine, cyclophosphamide and prednisone).
- Author
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Mandelli F, Biagini C, Baroni CD, Bosman C, Anselmo AP, de Luca AM, Granati L, Petti N, and Papa G
- Subjects
- Adolescent, Adult, Aged, Child, Child, Preschool, Drug Therapy, Combination, Female, Humans, Male, Middle Aged, Cyclophosphamide therapeutic use, Lymphoma drug therapy, Prednisone therapeutic use, Procarbazine therapeutic use, Vinblastine therapeutic use
- Published
- 1980
21. The time course of radioprotection by WR 2721 in mouse skin.
- Author
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Travis EL, De Luca AM, Fowler JF, and Padikal TN
- Subjects
- Animals, Dose-Response Relationship, Radiation, Electrons, Male, Mice, Mice, Inbred BALB C, Skin drug effects, Time Factors, Amifostine therapeutic use, Organothiophosphorus Compounds therapeutic use, Radiation Injuries, Experimental prevention & control, Skin radiation effects
- Abstract
The radioprotective effect of 400 mg/kg of WR 2721 on mouse skin has been investigated over a series of times from 5 to 60 minutes after intravenous or intraperitoneal injection of the drug. The acute desquamation reaction on the hind leg of white mice was studied. Dose response curves were obtained for the average reaction over 15 to 25 days after single-dose irradiation. A high dose-rate electron beam (13--17 Gy/min) was used to minimize the irradiation time. Single doses of 20 to 60 grays were given. Dose modifying factors (DMFs) of 1.7--2.1 were obtained at 30 to 60 minutes, but only 1.1 to 1.3 at 5 minutes and intermediate values at 10 and 15 minutes. DMFs rose slightly faster and to slightly higher values after i.v. than after i.p. injection of WR 2721. We conclude that 30 minutes is the shortest interval which should be used between injection of Wr 2721 and irradiation with this normal tissue.
- Published
- 1982
- Full Text
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22. Protection of mouse lung by WR-2721 after fractionated doses of irradiation.
- Author
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Travis EL and De Luca AM
- Subjects
- Animals, Dose-Response Relationship, Radiation, Female, Mice, Pneumonia prevention & control, Pulmonary Fibrosis prevention & control, Time Factors, Amifostine therapeutic use, Lung radiation effects, Organothiophosphorus Compounds therapeutic use, Radiation Injuries, Experimental prevention & control, Radiation-Protective Agents therapeutic use
- Abstract
The radioprotective effect of WR-2721 on mouse lung has been studied after single doses, 4 or 7 equal fractions of X rays. Using breathing rate and lethality to measure lung injury up to 1 year after radiation, significant protection against both pneumonitis at 7 months and fibrosis at 12 months was observed using 300 mg/kg of WR-2721. The degree of radioprotection was similar for pneumonitis and fibrosis and was not less after doses per fraction of 4.0 Gy. These data indicate that protection of mouse lung by WR-2721 will not be less in a multifractionated schedule of radiation, at least for doses per fraction greater than 4.0 Gy.
- Published
- 1985
- Full Text
- View/download PDF
23. Mechanoelectricity of the crystalline lens.
- Author
-
Cerquiglini S, Marchetti M, Salleo A, Figura F, and De Luca AM
- Subjects
- Accommodation, Ocular physiology, Animals, Cattle, Electrophysiology, In Vitro Techniques, Pressure, Lens, Crystalline physiology
- Published
- 1967
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