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1. Prediction of Isolated Local Recurrence After Resection of Pancreatic Ductal Adenocarcinoma: A Nationwide Study

Author

van Goor, I. W. J. M., Andel, P. C. M., Buijs, F. S., Besselink, M. G., Bonsing, B. A., Bosscha, K., Busch, O. R., Cirkel, G. A., van Dam, R. M., Festen, S., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H. J. T., Kazemier, G., Liem, M. S. L., Meijer, G., de Meijer, V. E., Nieuwenhuijs, V. B., Roos, D., Schreinemakers, J. M. J., Stommel, M. W. J., Wit, F., Verdonk, R. C., van Santvoort, H. C., Molenaar, I. Q., Intven, M. P. W., and Daamen, L. A.

Published
2024
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2. Correction: Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a recurrence-focused surveillance strategy (RADAR-PANC): protocol of an international randomized controlled trial according to the Trials within Cohorts design

Author

Daamen, L. A., van Goor, I. W. J. M., Groot, V. P., Andel, P. C. M., Brosens, L. A. A., Busch, O. R., Cirkel, G. A., Mohammad, N. Haj, Heerkens, H. D., de Hingh, I. H. J. T., Hoogwater, F., van Laarhoven, H. W. M., Los, M., Meijer, G. J., de Meijer, V. E., Pande, R., Roberts, K. J., Stoker, J., Stommel, M. W. J., van Tienhoven, G., Verdonk, R. C., Verkooijen, H. M., Wessels, F. J., Wilmink, J. W., Besselink, M. G., van Santvoort, H. C., Intven, M. P. W., and Molenaar, I. Q.

Published
2024
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3. Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a recurrence-focused surveillance strategy (RADAR-PANC): protocol of an international randomized controlled trial according to the Trials within Cohorts design

Author

Daamen, L. A., van Goor, I. W. J. M., Groot, V. P., Andel, P. C. M., Brosens, L. A. A., Busch, O. R., Cirkel, G. A., Mohammad, N. Haj, Heerkens, H. D., de Hingh, I. H. J. T., Hoogwater, F., van Laarhoven, H. W. M., Los, M., Meijer, G. J., de Meijer, V. E., Pande, R., Roberts, K. J., Stoker, J., Stommel, M. W. J., van Tienhoven, G., Verdonk, R. C., Verkooijen, H. M., Wessels, F. J., Wilmink, J. W., Besselink, M. G., van Santvoort, H. C., Intven, M. P. W., and Molenaar, I. Q.

Published
2024
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5. Aandoeningen van lever, galwegen en pancreas bij kinderen

Author

de Kleine, R. H. J., Bruggink, J. L. M., de Meijer, V. E., Hulscher, J. B. F., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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6. Lever en galwegen

Author

Verhoef, C., de Meijer, V. E., Heineman, E., editor, Heineman, D.J., editor, Lange jr., J.F.M., editor, Blankensteijn, J.D., editor, Boermeester, M.A., editor, Borel Rinkes, I.H.M., editor, Klaase, J.M., editor, Schipper, I.B., editor, Schreurs, W.H., editor, and Wijnen, R.M.H., editor

Published
2021
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7. ASO Visual Abstract: Short- and Long-Term Outcomes of Pancreatic Cancer Resection for Elderly Patients: A Nationwide Analysis

Author

Henry, A. C., Schouten, T. J., Daamen, L. A., Walma, M. S., Noordzij, P., Cirkel, G. A., Los, M., Besselink, M. G., Busch, O. R., Bonsing, B. A., Bosscha, K., van Dam, R. M., Festen, S., Groot Koerkamp, B., van der Harst, E., de Hingh, I. H. J. T., Kazemier, G., Liem, M. S., de Meijer, V. E., Nieuwenhuijs, V. B., Roos, D., Schreinemakers, J. M. J., Stommel, M. W. J., Molenaar, I. Q., and van Santvoort, H. C.

Published
2022
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8. Correction: Recurrent disease detection after resection of pancreatic ductal adenocarcinoma using a recurrence-focused surveillance strategy (RADAR-PANC): protocol of an international randomized controlled trial according to the Trials within Cohorts design(Trials, (2023), 25, 401, 10.1186/s13063-024-08223-5)

Author

Trialbureau Beeld, Cancer, Zorgeenheid Kinderchirurgie Medisch, Onderzoek Radiotherapie, Heelkunde Opleiding, MS CGO, Pathologie Pathologen staf, MS Medische Oncologie, Medisch Oncologische Disciplines, Klinische Fysica RT, Arts-assistenten Radiologie, MS HOD, MS Radiotherapie, Daamen, L. A., van Goor, I. W.J.M., Groot, V. P., Andel, P. C.M., Brosens, L. A.A., Busch, O. R., Cirkel, G. A., Mohammad, N. Haj, Heerkens, H. D., de Hingh, I. H.J.T., Hoogwater, F., van Laarhoven, H. W.M., Los, M., Meijer, G. J., de Meijer, V. E., Pande, R., Roberts, K. J., Stoker, J., Stommel, M. W.J., van Tienhoven, G., Verdonk, R. C., Verkooijen, H. M., Wessels, F. J., Wilmink, J. W., Besselink, M. G., van Santvoort, H. C., Intven, M. P.W., Molenaar, I. Q., for the Dutch Pancreatic Cancer Group, Trialbureau Beeld, Cancer, Zorgeenheid Kinderchirurgie Medisch, Onderzoek Radiotherapie, Heelkunde Opleiding, MS CGO, Pathologie Pathologen staf, MS Medische Oncologie, Medisch Oncologische Disciplines, Klinische Fysica RT, Arts-assistenten Radiologie, MS HOD, MS Radiotherapie, Daamen, L. A., van Goor, I. W.J.M., Groot, V. P., Andel, P. C.M., Brosens, L. A.A., Busch, O. R., Cirkel, G. A., Mohammad, N. Haj, Heerkens, H. D., de Hingh, I. H.J.T., Hoogwater, F., van Laarhoven, H. W.M., Los, M., Meijer, G. J., de Meijer, V. E., Pande, R., Roberts, K. J., Stoker, J., Stommel, M. W.J., van Tienhoven, G., Verdonk, R. C., Verkooijen, H. M., Wessels, F. J., Wilmink, J. W., Besselink, M. G., van Santvoort, H. C., Intven, M. P.W., Molenaar, I. Q., and for the Dutch Pancreatic Cancer Group

Published
2024

9. Prediction Model for Severe Morbidity and Diabetes Type III after Central Pancreatectomy: Patient Selection in an International Retrospective Multicenter Study

Author

van Bodegraven, E.A., primary, Lof, S., additional, Jones, L., additional, Aussilhou, B., additional, Yong, G., additional, Jishu, W., additional, Klotz, R., additional, Rocha-Castellanos, D.M., additional, Matsumato, I., additional, de Ponthaud, C., additional, Tanaka, K., additional, Biesel, E., additional, Kauffmann, E., additional, Dumitrascu, T., additional, Nagakawa, Y., additional, Martí-Cruchaga, P., additional, Roeyen, G., additional, Zerbi, A., additional, Goetz, M., additional, de Meijer, V., additional, Pessaux, P., additional, Ignatavicius, P., additional, Demir, I., additional, Giuffrida, M., additional, Tingstedt, B., additional, Marino, M.V., additional, Mastoridis, S., additional, Brunner, M., additional, Mora-Oliver, I., additional, Bortolato, C., additional, Gulla, A., additional, Apers, T., additional, Hermand, H., additional, Mitsuka, Y., additional, Popescu, I., additional, Boggi, U., additional, Wittel, U., additional, Hirano, S., additional, Gaujoux, S., additional, Kamei, K., additional, Fernández-Del Castillo, C., additional, Hackert, T., additional, Kuirong, J., additional, Yi, M., additional, and Sauvanet, A., additional

Published
2023
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12. OC-0111 Prognostic factors for isolated local recurrence after resection of pancreatic ductal adenocarcinoma

Author

van Goor, I., primary, Nagelhout, A., additional, Besselink, M., additional, Bonsing, B., additional, Bosscha, K., additional, Brosens, L., additional, Busch, O., additional, Cirkel, G., additional, van Dam, R., additional, Festen, S., additional, Groot Koerkamp, B., additional, van der Harst, E., additional, de Hingh, I., additional, Kazemier, G., additional, Meijer, G., additional, de Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Verdonk, R., additional, van Santvoort, H., additional, Molenaar, Q., additional, Daamen, L., additional, and Intven, M., additional

Published
2022
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13. Prolonged preservation by hypothermic machine perfusion facilitates logistics in liver transplantation: a European observational cohort study

Author

Brüggenwirth, I, Mueller, M, Lantinga, V, Camagni, S, De Carlis, R, De Carlis, L, Colledan, M, Dondossola, D, Drefs, M, Eden, J, Ghinolfi, D, Koliogiannis, D, Lurje, G, Manzia, T, Monbaliu, D, Muiesan, P, Patrono, D, Pratschke, J, Romagnoli, R, Rayar, M, Roma, F, Schlegel, A, Dutkowski, P, Porte, R, de Meijer, V, Brüggenwirth, Isabel M A, Mueller, Matteo, Lantinga, Veerle A, Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M, Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J, de Meijer, Vincent E, Brüggenwirth, I, Mueller, M, Lantinga, V, Camagni, S, De Carlis, R, De Carlis, L, Colledan, M, Dondossola, D, Drefs, M, Eden, J, Ghinolfi, D, Koliogiannis, D, Lurje, G, Manzia, T, Monbaliu, D, Muiesan, P, Patrono, D, Pratschke, J, Romagnoli, R, Rayar, M, Roma, F, Schlegel, A, Dutkowski, P, Porte, R, de Meijer, V, Brüggenwirth, Isabel M A, Mueller, Matteo, Lantinga, Veerle A, Camagni, Stefania, De Carlis, Riccardo, De Carlis, Luciano, Colledan, Michele, Dondossola, Daniele, Drefs, Moritz, Eden, Janina, Ghinolfi, Davide, Koliogiannis, Dionysios, Lurje, Georg, Manzia, Tommaso M, Monbaliu, Diethard, Muiesan, Paolo, Patrono, Damiano, Pratschke, Johann, Romagnoli, Renato, Rayar, Michel, Roma, Federico, Schlegel, Andrea, Dutkowski, Philipp, Porte, Robert J, and de Meijer, Vincent E

Abstract

A short period (1–2 h) of hypothermic oxygenated machine perfusion (HOPE) after static cold storage is safe and reduces ischemia-reperfusion injury-related complications after liver transplantation. Machine perfusion time is occasionally prolonged for logistical reasons, but it is unknown if prolonged HOPE is safe and compromises outcomes. We conducted a multicenter, observational cohort study of patients transplanted with a liver preserved by prolonged (≥4 h) HOPE. Postoperative biochemistry, complications, and survival were evaluated. The cohort included 93 recipients from 12 European transplant centers between 2014–2021. The most common reason to prolong HOPE was the lack of an available operating room to start the transplant procedure. Grafts underwent HOPE for a median (range) of 4:42 h (4:00–8:35 h) with a total preservation time of 10:50 h (5:50–20:50 h). Postoperative peak ALT was 675 IU/L (interquartile range 419–1378 IU/L). The incidence of postoperative complications was low, and 1-year graft and patient survival were 94% and 88%, respectively. To conclude, good outcomes are achieved after transplantation of donor livers preserved with prolonged (median 4:42 h) HOPE, leading to a total preservation time of almost 21 h. These results suggest that simple, end-ischemic HOPE may be utilized for safe extension of the preservation time to ease transplantation logistics.

Published
2022

14. Treatment of Recurrence and Post-Recurrence Survival after Different Primary Treatment Strategies for Patients with Pancreatic Cancer

Author

Andel, P., primary, van Goor, I., additional, Besselink, M., additional, Bonsing, B., additional, Bosscha, K., additional, Brosens, L., additional, Busch, O., additional, Cirkel, G., additional, Van Dam, R., additional, Festen, S., additional, Koerkamp, B. Groot, additional, Van der Harst, E., additional, De Hingh, I., additional, Intven, M., additional, Kazemier, G., additional, Los, M., additional, Meijer, G., additional, De Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Verdonk, R., additional, Van Santvoort, H., additional, and Molenaar, I., additional

Published
2022
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15. Study Protocol for a Multicenter Nationwide Prospective Cohort Study to Investigate the Natural Course and Clinical Outcome in Benign Liver Tumors and Cysts in The Netherlands: The BELIVER Study

Author

Furumaya, A., primary, Haring, M., additional, van Rosmalen, B., additional, Klompenhouwer, J., additional, Besselink, M., additional, de Man, R., additional, IJzermans, J., additional, Thomeer, M., additional, Kramer, M., additional, Coolsen, M., additional, Tushuizen, M., additional, Schaapherder, A., additional, de Haas, R., additional, Duiker, E., additional, Kazemier, G., additional, van Delden, O., additional, Verheij, J., additional, Takkenberg, B., additional, Cuperus, F., additional, de Meijer, V., additional, and Erdmann, J., additional

Published
2022
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16. Prognostic Factors Associated with Long-Term Recurrence-Free Survival after Resection of Pancreatic Ductal Adenocarcinoma (PDAC): A Nationwide Analysis

Author

van Goor, I., primary, Schouten, T., additional, Besselink, M., additional, Bonsing, B., additional, Bosscha, K., additional, Brosens, L., additional, Busch, O., additional, Cirkel, G., additional, van Dam, R., additional, Festen, S., additional, Koerkamp, B. Groot, additional, van der Harst, E., additional, de Hingh, I., additional, Intven, M., additional, Kazemier, G., additional, Los, M., additional, de Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Verdonk, R., additional, van Santvoort, H., additional, Daamen, L., additional, and Molenaar, I., additional

Published
2022
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17. Short- and Long-term Outcomes of Surgery for Pancreatic Cancer in the Elderly

Author

Henry, A.C., primary, Schouten, T., additional, Daamen, L., additional, Walma, M., additional, Noordzij, P., additional, Besselink, M., additional, Busch, O., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Festen, S., additional, Koerkamp, B. Groot, additional, van der Harst, E., additional, de Hingh, I., additional, Kazemier, G., additional, Liem, M., additional, de Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Molenaar, Q., additional, and van Santvoort, H., additional

Published
2022
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18. The Impact of Complications after Resection of Pancreatic Ductal Adenocarcinoma on Disease Recurrence

Author

Henry, A.C., primary, van Goor, I., additional, Daamen, L., additional, Smits, J., additional, Nagelhout, A., additional, Besselink, M., additional, Busch, O., additional, van Eijck, C., additional, Bonsing, B., additional, Bosscha, K., additional, van Dam, R., additional, Festen, S., additional, Koerkamp, B. Groot, additional, van der Harst, E., additional, de Hingh, I., additional, van der Kolk, M., additional, Liem, M., additional, de Meijer, V., additional, Patijn, G., additional, Roos, D., additional, Schreinemakers, J., additional, Wit, F., additional, Zonderhuis, B., additional, Molenaar, Q., additional, and van Santvoort, H., additional

Published
2022
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19. Early Detection and Minimally Invasive Management of Complications Reduces Mortality After Pancreatic Resection: The Nationwide PORSCH Trial

Author

Henry, A., Smits, F., Besselink, M. G., Busch, O., van Eijck, C. H., Arntz, M., Bollen, T., van Delden, O., van den Heuvel, D., van der Leij, C., van Lienden, K., Moelker, A., Bonsing, B., Rinkes, I. Borel, Bosscha, K., van Dam, R. M., Derksen, W., den Dulk, M., Festen, S., Koerkamp, B. Groot, Hagendoorn, J., van der Harst, E., de Hingh, I. H., Kazemier, G., van der Kolk, M., Liem, M., Lips, D., de Meijer, V. E., Mieog, S., Patijn, G., Te Riele, W. W., Roos, D., Schreinemakers, J., Stommel, M., Wit, F., Zonderhuis, B., Daamen, L., van Werkhoven, C., Molenaar, I., van Santvoort, H., Surgery, General Practice, Immunology, Radiology & Nuclear Medicine, Erasmus School of Economics, Erasmus MC other, Pediatric Surgery, Intensive Care, Pharmacy, Medical Oncology, Department of Organisation and Personnel Management, Anesthesiology, Pulmonary Medicine, Groningen Institute for Organ Transplantation (GIOT), and Center for Liver, Digestive and Metabolic Diseases (CLDM)

Published
2021

22. Short- and long-term outcomes of surgery for pancreatic cancer in the elderly

Author

Henry, A.C., primary, Schouten, T., additional, Daamen, L., additional, Walma, M., additional, Noordzij, P., additional, Besselink, M., additional, Busch, O., additional, Bonsing, B., additional, Bosscha, K., additional, Van Dam, R., additional, Festen, S., additional, Koerkamp, B. Groot, additional, Van Der Harst, E., additional, De Hingh, I., additional, Kazemier, G., additional, Liem, M., additional, De Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Molenaar, Q., additional, and Van Santvoort, H., additional

Published
2021
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23. Survival benefit of resection of locally advanced pancreatic cancer following upfront FOLFIRINOX versus FOLFIRINOX only treatment: A propensity score-matched analysis

Author

Brada, L., primary, Daamen, L., additional, Magermans, L., additional, Walma, M., additional, Latifi, D., additional, van Dam, R., additional, de Hingh, I., additional, Liem, M., additional, de Meijer, V., additional, Patijn, G., additional, Festen, S., additional, Stommel, M., additional, Bosscha, K., additional, Polee, M., additional, Nio, Y., additional, Wessels, F., additional, de Vries, J., additional, van Lienden, K., additional, Bruijnen, R., additional, Busch, O., additional, Koerkamp, B. Groot, additional, van Eijck, C., additional, Molenaar, Q., additional, Wilmink, H., additional, van Santvoort, H., additional, and Besselink, M., additional

Published
2021
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24. Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy:a multicentre cohort study and meta-analysis

Author

Groen, J., Smits, F. J., Koole, D., Besselink, M. G., Busch, O. R., den Dulk, M., van Eijck, C. H. J., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H., Karsten, T. M., de Meijer, V. E., Pranger, B. K., Molenaar, I. Q., Bonsing, B. A., van Santvoort, H. C., Mieog, J. S. D., Groen, J., Smits, F. J., Koole, D., Besselink, M. G., Busch, O. R., den Dulk, M., van Eijck, C. H. J., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H., Karsten, T. M., de Meijer, V. E., Pranger, B. K., Molenaar, I. Q., Bonsing, B. A., van Santvoort, H. C., and Mieog, J. S. D.

Abstract

BACKGROUND: Despite the fact that primary percutaneous catheter drainage has become standard practice, some patients with pancreatic fistula after pancreatoduodenectomy ultimately undergo a relaparotomy. The aim of this study was to compare completion pancreatectomy with a pancreas-preserving procedure in patients undergoing relaparotomy for pancreatic fistula after pancreatoduodenectomy. METHODS: This retrospective cohort study of nine institutions included patients who underwent relaparotomy for pancreatic fistula after pancreatoduodenectomy from 2005-2018. Furthermore, a systematic review and meta-analysis were performed according to the PRISMA guidelines. RESULTS: From 4877 patients undergoing pancreatoduodenectomy, 786 (16 per cent) developed a pancreatic fistula grade B/C and 162 (3 per cent) underwent a relaparotomy for pancreatic fistula. Of these patients, 36 (22 per cent) underwent a completion pancreatectomy and 126 (78 per cent) a pancreas-preserving procedure. Mortality was higher after completion pancreatectomy (20 (56 per cent) versus 40 patients (32 per cent); P = 0.009), which remained after adjusting for sex, age, BMI, ASA score, previous reintervention, and organ failure in the 24 h before relaparotomy (adjusted odds ratio 2.55, 95 per cent c.i. 1.07 to 6.08). The proportion of additional reinterventions was not different between groups (23 (64 per cent) versus 84 patients (67 per cent); P = 0.756). The meta-analysis including 33 studies evaluating 745 patients, confirmed the association between completion pancreatectomy and mortality (Mantel-Haenszel random-effects model: odds ratio 1.99, 95 per cent c.i. 1.03 to 3.84). CONCLUSION: Based on the current data, a pancreas-preserving procedure seems preferable to completion pancreatectomy in patients in whom a relaparotomy is deemed necessary for pancreatic fistula after pancreatoduodenectomy.

Published
2021

25. Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy: a multicentre cohort study and meta-analysis

Author

MS CGO, Heelkunde Opleiding, Cancer, MS HOD, Groen, J., V, Smits, F. J., Koole, D., Besselink, M. G., Busch, O. R., den Dulk, M., van Eijck, C. H. J., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H., Karsten, T. M., de Meijer, V. E., Pranger, B. K., Molenaar, I. Q., Bonsing, B. A., van Santvoort, H. C., Mieog, J. S. D., MS CGO, Heelkunde Opleiding, Cancer, MS HOD, Groen, J., V, Smits, F. J., Koole, D., Besselink, M. G., Busch, O. R., den Dulk, M., van Eijck, C. H. J., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H., Karsten, T. M., de Meijer, V. E., Pranger, B. K., Molenaar, I. Q., Bonsing, B. A., van Santvoort, H. C., and Mieog, J. S. D.

Published
2021

28. Survival benefit of resection of locally advanced pancreatic cancer following upfront FOLFIRINOX versus FOLFIRINOX only treatment: a multicenter propensity score-matched analysis

Author

Brada, L., primary, Daamen, L., additional, Magermans, L., additional, Walma, M., additional, Latifi, D., additional, van Dam, R., additional, de Hingh, I., additional, Liem, M., additional, de Meijer, V., additional, Patijn, G., additional, Festen, S., additional, Stommel, M., additional, Bosscha, K., additional, Polée, M., additional, Nio, C., additional, Wessels, F., additional, de Vries, J., additional, van Lienden, K., additional, Bruijnen, R., additional, Busch, O., additional, Koerkamp, B Groot, additional, van Eijck, C., additional, Molenaar, I., additional, Wilmink, J., additional, van Santvoort, H., additional, and Besselink, M., additional

Published
2021
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31. Development and internal validation of two preoperative nomograms for predicting early and very early disease recurrence after primary resection of pancreatic ductal adenocarcinoma

Author

Daamen, L., primary, Dorland, G., additional, Besselink, M., additional, Bosscha, K., additional, Bonsing, B., additional, Busch, O., additional, Cirkel, G., additional, Van Dam, R., additional, Festen, S., additional, Groot Koerkamp, B., additional, Haj Mohammad, N., additional, Harst E., Van Der, additional, De Hingh, I., additional, Intven, M., additional, Kazemier, G., additional, Los, M., additional, De Meijer, V., additional, Nieuwenhuijs, V., additional, Roos, D., additional, Schreinemakers, J., additional, Stommel, M., additional, Verdonk, R., additional, Verkooijen, L., additional, Molenaar, Q., additional, and Van Santvoort, H., additional

Published
2020
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32. The treatment of older patients with locally advanced pancreatic cancer. A prospective cohort study.

Author

Brada, L., primary, Walma, M., additional, Van Dam, R., additional, De Vos-Geelen, J., additional, De Hingh, I., additional, Creemers, G., additional, Liem, M., additional, Mekenkamp, L., additional, De Meijer, V., additional, De Groot, D., additional, Patijn, G., additional, De Groot, W., additional, Festen, S., additional, Kerver, E., additional, Stommel, M., additional, Meijerink, M., additional, Bosscha, K., additional, Pruijt, H., additional, Polée, M., additional, Ropela, A., additional, Cirkel, G., additional, Los, M., additional, Wilmink, H., additional, Haj Mohammad, N., additional, Van Santvoort, H., additional, Besselink, M., additional, and Molenaar, Q., additional

Published
2020
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33. Development and internal validation of two nomograms predicting outcomes in patients with locally advanced pancreatic cancer starting treatment with FOLFIRINOX

Author

Brada, L., primary, Walma, M., additional, Daamen, L., additional, Van Roessel, S., additional, Van Dam, R., additional, De Hingh, I., additional, Liem, M., additional, De Meijer, V., additional, Patijn, G., additional, Festen, S., additional, Stommel, M., additional, Meijerink, M., additional, Bosscha, K., additional, Polée, M., additional, Ropela, A., additional, Nio, Y., additional, Wessels, F., additional, Van Leeuwen, M., additional, De Vries, J., additional, Van Lienden, K., additional, Bruijnen, R., additional, Busch, O., additional, Besselink, M., additional, Molenaar, Q., additional, and Van Santvoort, H., additional

Published
2020
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35. Biliary bicarbonate, pH and glucose are suitable biomarkers of biliary viability during ex situ normothermic machine perfusion of human donor livers

Author

Matton, A. P. M., de Vries, Y., van Leeuwen, O. B., Burlage, L. C., van Rijn, R., Fujiyoshi, M., de Meijer, V. E., Ubbink, R., Pelgrim, G. J., Werner, M. J. M., Reyntjens, K., van den Berg, A. P., de Boer, M. T., de Kleine, R. H. J., Verkade, H. J., Gouw, A. S. H., Lisman, T., Porte, R. J., Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), and Lifestyle Medicine (LM)

Published
2019

36. Completion pancreatectomy or a pancreas-preserving procedure during relaparotomy for pancreatic fistula after pancreatoduodenectomy: a multicentre cohort study and meta-analysis.

Author

Groen, J. V., Smits, F. J., Koole, D., Besselink, M. G., Busch, O. R., den Dulk, M., van Eijck, C. H. J., Koerkamp, B. Groot, van der Harst, E., de Hingh, I. H., Karsten, T. M., de Meijer, V. E., Pranger, B. K., Molenaar, I. Q., Bonsing, B. A., van Santvoort, H. C., and Mieog, J. S. D.

Subjects
PANCREATECTOMY, PANCREATIC fistula, PANCREATICODUODENECTOMY, COHORT analysis, ODDS ratio
Abstract

Background: Despite the fact that primary percutaneous catheter drainage has become standard practice, some patients with pancreatic fistula after pancreatoduodenectomy ultimately undergo a relaparotomy. The aim of this study was to compare completion pancreatectomy with a pancreas-preserving procedure in patients undergoing relaparotomy for pancreatic fistula after pancreatoduodenectomy. Methods: This retrospective cohort study of nine institutions included patients who underwent relaparotomy for pancreatic fistula after pancreatoduodenectomy from 2005-2018. Furthermore, a systematic review and meta-analysis were performed according to the PRISMA guidelines. Results: From 4877 patients undergoing pancreatoduodenectomy, 786 (16 per cent) developed a pancreatic fistula grade B/C and 162 (3 per cent) underwent a relaparotomy for pancreatic fistula. Of these patients, 36 (22 per cent) underwent a completion pancreatectomy and 126 (78 per cent) a pancreas-preserving procedure. Mortality was higher after completion pancreatectomy (20 (56 per cent) versus 40 patients (32 per cent); P=0.009), which remained after adjusting for sex, age, BMI, ASA score, previous reintervention, and organ failure in the 24 h before relaparotomy (adjusted odds ratio 2.55, 95 per cent c.i. 1.07 to 6.08). The proportion of additional reinterventions was not different between groups (23 (64 per cent) versus 84 patients (67 per cent); P=0.756). The meta-analysis including 33 studies evaluating 745 patients, confirmed the association between completion pancreatectomy and mortality (Mantel-Haenszel random-effects model: odds ratio 1.99, 95 per cent c.i. 1.03 to 3.84). Conclusion: Based on the current data, a pancreas-preserving procedure seems preferable to completion pancreatectomy in patients in whom a relaparotomy is deemed necessary for pancreatic fistula after pancreatoduodenectomy. [ABSTRACT FROM AUTHOR]

Published
2021
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37. Nationwide trends in incidence, treatment and survival of patients with pancreatic cancer in the past two decades

Author

Latenstein, A., primary, Van der Geest, L., additional, Vissers, P., additional, Verheij, J., additional, De Meijer, V., additional, De Vos-Geelen, J., additional, Bonsing, B., additional, Van Tienhoven, G., additional, De Hingh, I., additional, Molenaar, I., additional, Groot Koerkamp, B., additional, Haj Mohammad, N., additional, Van Santvoort, H., additional, Busch, O., additional, Van Eijck, C., additional, Van Laarhoven, H., additional, Besselink, M., additional, and Wilmink, J., additional

Published
2020
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38. Textbook outcome as a novel quality measure in pancreatic surgery: a nationwide analysis

Author

Van Roessel, S., primary, Mackay, T., additional, Van Dieren, S., additional, Van der Schelling, G., additional, Nieuwenhuijs, V., additional, Bosscha, K., additional, Van der Harst, E., additional, Van Dam, R., additional, Liem, M., additional, Festen, S., additional, Stommel, M., additional, Roos, D., additional, Wit, F., additional, Molenaar, Q., additional, De Meijer, V., additional, De Hingh, I., additional, Van Santvoort, H., additional, Bonsing, B., additional, Busch, O., additional, Koerkamp, B Groot, additional, and Besselink, M., additional

Published
2020
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39. Predicting the risk of not receiving adjuvant chemotherapy after resection of pancreatic ductal adenocarcinoma: a nationwide analysis

Author

Mackay, T., primary, Smits, F., additional, Roos, D., additional, Bonsing, B., additional, Bosscha, K., additional, Busch, O., additional, Creemers, G., additional, Van Dam, R., additional, Van Eijck, C., additional, Gerhards, M., additional, De Groot, J., additional, Koerkamp, B Groot, additional, Mohammad, N Haj, additional, Van der Harst, E., additional, De Hingh, I., additional, Homs, M., additional, Kazemier, G., additional, Liem, M., additional, De Meijer, V., additional, Molenaar, I., additional, Nieuwenhuijs, V., additional, Van Santvoort, H., additional, Van der Schelling, G., additional, Stommel, M., additional, Tije, A Ten, additional, De Vos-Geelen, J., additional, Wit, F., additional, Wilmink, J., additional, Van Laarhoven, H., additional, and Besselink, M., additional

Published
2020
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40. Safety and efficacy of transarterial embolization of hepatocellular adenomas

Author

van Rosmalen, B V, primary, Klompenhouwer, A J, additional, de Graeff, J Jaap, additional, Haring, M P D, additional, de Meijer, V E, additional, Rifai, L, additional, Dokmak, S, additional, Rawashdeh, A, additional, Abu Hilal, M, additional, de Jong, M C, additional, Dejong, C H C, additional, Doukas, M, additional, de Man, R A, additional, IJzermans, J N M, additional, van Delden, O M, additional, Verheij, J, additional, and van Gulik, T M, additional

Published
2019
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41. Effect of centralization and regionalization of pancreatic surgery on resection rates and survival.

Author

Latenstein, A. E. J., Mackay, T. M., van der Geest, L. G. M., van Eijck, C. H. J., de Meijer, V. E., Stommel, M. W. J., Vissers, P. A. J., Besselink, M. G., and de Hingh, I. H. J. T.

Subjects
PANCREATIC surgery, SURVIVAL rate, SURGICAL excision, PANCREATIC cancer, OVERALL survival, CANCER diagnosis
Abstract

Background: Centralization of pancreatic surgery in the Netherlands has been ongoing since 2011. The aim of this study was to assess how centralization has affected the likelihood of resection and survival of patients with non-metastatic pancreatic head and periampullary cancer, diagnosed in hospitals with and without pancreatic surgery services. Methods: An observational cohort study was performed on nationwide data from the Netherlands Cancer Registry (2009-2017), including patients diagnosed with non-metastatic pancreatic head or periampullary cancer. The period of diagnosis was divided into three time intervals: 2009-2011, 2012-2014 and 2015-2017. Hospital of diagnosis was classified as a pancreatic or non-pancreatic surgery centre. Analyses were performed using multivariable logistic and Cox regression models. Results: In total, 10 079 patients were included, of whom 3114 (30.9 per cent) were diagnosed in pancreatic surgery centres. Between 2009-2011 and 2015-2017, the number of patients undergoing resection increased from 1267 of 3169 (40.0 per cent) to 1705 of 3566 (47.8 per cent) (P for trend < 0.001). In multivariable analysis, in 2015-2017, unlike the previous periods, patients diagnosed in pancreatic and non-pancreatic surgery centres had a similar likelihood of resection (odds ratio 1.08, 95 per cent c.i. 0.90 to 1.28; P = 0.422). In this period, however, overall survival was higher in patients diagnosed in pancreatic surgery than in those diagnosed in non-pancreatic surgery centres (hazard ratio 0.92, 95 per cent c.i. 0.85 to 0.99; P = 0.047). Conclusion: Aftercentralization of pancreatic surgery, the resection rate forpatients with pancreatic head and periampullary cancer diagnosed in non-pancreatic surgery centres increased and became similar to that in pancreatic surgery centres. Overall survival remained higherin patients diagnosed in pancreatic surgery centres. [ABSTRACT FROM AUTHOR]

Published
2021
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42. INDICATIONS AND OUTCOMES OF PEDIATRIC LIVER RETRANSPLANTATION IN EUROPE. ANALYSIS OF A EUROPEAN LIVER REGISTRY-BASED COHORT

Author

Werner, M, Bruggenwirth, I, Adam, R, Polak, W, Karam, V, Branchereau, S, Fischer, L, Colledan, M, Vega, P, Porte, R, de Meijer, V, Werner MJM, Bruggenwirth IMA, Adam R, Polak WG, Karam V, Branchereau S, Fischer L, Colledan M, Vega PJ, Porte RJ, de Meijer VE, Werner, M, Bruggenwirth, I, Adam, R, Polak, W, Karam, V, Branchereau, S, Fischer, L, Colledan, M, Vega, P, Porte, R, de Meijer, V, Werner MJM, Bruggenwirth IMA, Adam R, Polak WG, Karam V, Branchereau S, Fischer L, Colledan M, Vega PJ, Porte RJ, and de Meijer VE

Published
2019

43. Levertransplantaties bij kinderen in Nederland

Author

Werner, M J M, de Kleine, R H J, Bodewes, F A J A, de Boer, M T, de Jong, K P, de Meijer, V E, Scheenstra, R, Sieders, E, Verkade, H J J, Porte, R J, Groningen Institute for Organ Transplantation, Guided Treatment in Optimal Selected Cancer Patients, Center for Liver, Digestive and Metabolic Diseases, and Lifestyle Medicine

Subjects
Journal Article, English Abstract
Abstract

OBJECTIVE: To evaluate the results of the national paediatric liver transplantation programme in the University Medical Centre (UMC) Groningen in the Netherlands during the past two decades. DESIGN: Retrospective cohort study. METHOD: We analysed data from paediatric patients who underwent liver transplantation at UMC Groningen in the period 1995-2016. We compared outcomes from children who had undergone a liver transplantation in the period 1995-2005 (cohort A; n = 126) and in the period 2006-2016 (cohort B; n = 169). We performed a subanalysis in cohort B between liver transplantations with deceased donor livers (n = 132) and living donor liver transplantations (LDLT; n = 37). RESULTS: In cohort A, almost all livers came from deceased donors (99%), whereas in cohort B, 37 LDLTs (22%) were performed. The median age of recipients was significantly higher in cohort A (4.4 vs. 2.5 years; p = 0.015). Postoperative complications were comparable for both cohorts. Re-transplantations within a year after transplantation were more often performed in cohort A than in cohort B (25% vs. 12%; p = 0.004). Following LDLT, there was 2 times (5.4%) an indication for re-transplantation. In cohort B the 5-year survival rate was better than in cohort A (83 vs. 71%; p = 0.014). In cohort B, 5-year survival was higher after LDLT than after transplantation with a deceased donor liver (95 vs. 81%; p = 0.025). CONCLUSION: Outcomes after paediatric liver transplantation in the Netherlands have further improved during the past two decades. With an actuarial 5-year survival of 83% in the most recent cohort, and as high as 95% following LDLT, we can say that the UMC Groningen has a successful national paediatric liver transplant programme.

Published
2017

46. Pancreatoduodenectomy should be avoided when para-aortic lymph node metastases are found during surgical exploration for suspected pancreatic ductal adenocarcinoma

Author

Pranger, B., primary, Tseng, D., additional, Ubels, S., additional, Patijn, G., additional, Borel Rinkes, I.H., additional, Offerhaus, J.H., additional, Nieuwenhuis, V., additional, de Jong, K.P., additional, Klaase, J.M., additional, Molenaar, I.Q., additional, Erdmann, J., additional, and de Meijer, V., additional

Published
2018
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47. Outcome after pancreatic surgery in the pediatric, adolescent and young adult population (PAPAYA): a nationwide retrospective analysis

Author

Pranger, B., primary, van Eijck, C.H., additional, Groot. Koerkamp, B., additional, Bonsing, B.A., additional, Mieog, J.S., additional, Besselink, M.G., additional, Busch, O.R., additional, Stommel, M., additional, Gerhards, M.F., additional, van der Schelling, G.P., additional, de Jong, K., additional, and de Meijer, V., additional

Published
2018
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50. Prognostic factors for isolated local recurrence after resection of pancreatic ductal adenocarcinoma

Author

van Goor, I., Nagelhout, A., Besselink, M., Bonsing, B., Bosscha, K., Brosens, L., Busch, O., Cirkel, G., van Dam, R., Festen, S., Koerkamp, B. Groot, van der Harst, E., de Hingh, I., Kazemier, G., Meijer, G., de Meijer, V., Nieuwenhuijs, V., Roos, D., Schreinemakers, J., Stommel, M., Verdonk, R., van Santvoort, H., Molenaar, Q., Daamen, L., Intven, M., Groningen Institute for Organ Transplantation (GIOT), Center for Liver, Digestive and Metabolic Diseases (CLDM), Surgery, Erasmus School of Economics, Pediatric Surgery, Erasmus MC other, Intensive Care, Medical Oncology, and Department of Organisation and Personnel Management

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