Search

Your search keyword '"De Muynck, Louis"' showing total 28 results
Start Over Author "De Muynck, Louis"
Sorry, I don't understand your search. ×
28 results on '"De Muynck, Louis"'

4. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs

Author

Jiang, Jie, Zhu, Qiang, Gendron, Tania F, Saberi, Shahram, McAlonis-Downes, Melissa, Seelman, Amanda, Stauffer, Jennifer E, Jafar-nejad, Paymaan, Drenner, Kevin, Schulte, Derek, Chun, Seung, Sun, Shuying, Ling, Shuo-Chien, Myers, Brian, Engelhardt, Jeffery, Katz, Melanie, Baughn, Michael, Platoshyn, Oleksandr, Marsala, Martin, Watt, Andy, Heyser, Charles J, Ard, M Colin, De Muynck, Louis, Daughrity, Lillian M, Swing, Deborah A, Tessarollo, Lino, Jung, Chris J, Delpoux, Arnaud, Utzschneider, Daniel T, Hedrick, Stephen M, de Jong, Pieter J, Edbauer, Dieter, Van Damme, Philip, Petrucelli, Leonard, Shaw, Christopher E, Bennett, C Frank, Da Cruz, Sandrine, Ravits, John, Rigo, Frank, Cleveland, Don W, and Lagier-Tourenne, Clotilde

Subjects
Biological Psychology, Biomedical and Clinical Sciences, Neurosciences, Psychology, Brain Disorders, Genetics, Dementia, Neurodegenerative, Acquired Cognitive Impairment, Behavioral and Social Science, ALS, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Frontotemporal Dementia (FTD), Rare Diseases, Aetiology, 2.1 Biological and endogenous factors, Neurological, Amyotrophic Lateral Sclerosis, Animals, C9orf72 Protein, DNA Repeat Expansion, Frontotemporal Dementia, Guanine Nucleotide Exchange Factors, Mice, Transgenic, Neurons, Oligonucleotides, Antisense, RNA, Cognitive Sciences, Neurology & Neurosurgery, Biological psychology
Abstract

Hexanucleotide expansions in C9ORF72 are the most frequent genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Disease mechanisms were evaluated in mice expressing C9ORF72 RNAs with up to 450 GGGGCC repeats or with one or both C9orf72 alleles inactivated. Chronic 50% reduction of C9ORF72 did not provoke disease, while its absence produced splenomegaly, enlarged lymph nodes, and mild social interaction deficits, but not motor dysfunction. Hexanucleotide expansions caused age-, repeat-length-, and expression-level-dependent accumulation of RNA foci and dipeptide-repeat proteins synthesized by AUG-independent translation, accompanied by loss of hippocampal neurons, increased anxiety, and impaired cognitive function. Single-dose injection of antisense oligonucleotides (ASOs) that target repeat-containing RNAs but preserve levels of mRNAs encoding C9ORF72 produced sustained reductions in RNA foci and dipeptide-repeat proteins, and ameliorated behavioral deficits. These efforts identify gain of toxicity as a central disease mechanism caused by repeat-expanded C9ORF72 and establish the feasibility of ASO-mediated therapy.

Published
2016

5. RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Author

Hauer, Allard J., Kleinloog, Rachel, Giuliani, Fabrizio, Rinkel, Gabriël J.E., de Kort, Gerard A., Berkelbach van der Sprenkel, Jan Willem, van der Zwan, Albert, Gosselaar, Peter H., van Rijen, Peter C., de Boer-Bergsma, Jelkje J., Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Veldink, Jan H., Ruigrok, Ynte M., and Klijn, Catharina J.M.

Published
2019
Full Text
View/download PDF

6. Characterization ofAPOEChristchurch carriers in 455,306 UK Biobank participants

Author

He, Karen Y., primary, Khramtsova, Ekaterina A., additional, Cabrera-Socorro, Alfredo, additional, Zhang, Yanfei, additional, Li, Shuwei, additional, Sarver, Brice A. J., additional, Smets, Bart, additional, Li, Qingqin S., additional, De Muynck, Louis, additional, Parrado, Antonio R., additional, Lovestone, Simon, additional, and Black, Mary Helen, additional

Published
2022
Full Text
View/download PDF

8. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Kleinloog, Rachel, Verweij, Bon H., van der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., de Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, van der Zwan, Albert, Berkelbach van der Sprenkel, Jan W., Han, K. Sen, Gosselaar, Peter, van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016
Full Text
View/download PDF

12. RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Author

Brain, ZL Cerebrovasculaire Ziekten Medisch, Neurogenetica, Neurologie, Circulatory Health, MS Radiologie, Zorglijn FNE Medisch, ZL Neuromusculaire Ziekten Medisch, Hauer, Allard J, Kleinloog, Rachel, Giuliani, Fabrizio, Rinkel, Gabriël J E, de Kort, Gerard A, Berkelbach van der Sprenkel, Jan Willem, van der Zwan, Albert, Gosselaar, Peter H, van Rijen, Peter C, de Boer-Bergsma, Jelkje J, Deelen, Patrick, Swertz, Morris A, De Muynck, Louis, Van Damme, Philip, Veldink, Jan H, Ruigrok, Ynte M, Klijn, Catharina J M, Brain, ZL Cerebrovasculaire Ziekten Medisch, Neurogenetica, Neurologie, Circulatory Health, MS Radiologie, Zorglijn FNE Medisch, ZL Neuromusculaire Ziekten Medisch, Hauer, Allard J, Kleinloog, Rachel, Giuliani, Fabrizio, Rinkel, Gabriël J E, de Kort, Gerard A, Berkelbach van der Sprenkel, Jan Willem, van der Zwan, Albert, Gosselaar, Peter H, van Rijen, Peter C, de Boer-Bergsma, Jelkje J, Deelen, Patrick, Swertz, Morris A, De Muynck, Louis, Van Damme, Philip, Veldink, Jan H, Ruigrok, Ynte M, and Klijn, Catharina J M

Published
2020

15. RNA-Sequencing Highlights Inflammation and Impaired Integrity of the Vascular Wall in Brain Arteriovenous Malformations

Author

Hauer, Allard J., primary, Kleinloog, Rachel, additional, Giuliani, Fabrizio, additional, Rinkel, Gabriël J.E., additional, de Kort, Gerard A., additional, Berkelbach van der Sprenkel, Jan Willem, additional, van der Zwan, Albert, additional, Gosselaar, Peter H., additional, van Rijen, Peter C., additional, de Boer-Bergsma, Jelkje J., additional, Deelen, Patrick, additional, Swertz, Morris A., additional, De Muynck, Louis, additional, Van Damme, Philip, additional, Veldink, Jan H., additional, Ruigrok, Ynte M., additional, and Klijn, Catharina J.M., additional

Published
2020
Full Text
View/download PDF

18. Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

Author

Verheyen, An, primary, Diels, Annick, additional, Reumers, Joke, additional, Van Hoorde, Kirsten, additional, Van den Wyngaert, Ilse, additional, van Outryve d’Ydewalle, Constantin, additional, De Bondt, An, additional, Kuijlaars, Jacobine, additional, De Muynck, Louis, additional, De Hoogt, Ronald, additional, Bretteville, Alexis, additional, Jaensch, Steffen, additional, Buist, Arjan, additional, Cabrera-Socorro, Alfredo, additional, Wray, Selina, additional, Ebneth, Andreas, additional, Roevens, Peter, additional, Royaux, Ines, additional, and Peeters, Pieter J., additional

Published
2019
Full Text
View/download PDF

19. Genetically Engineered iPSC-Derived FTDP-17 MAPT Neurons Display Mutation-Specific Neurodegenerative and Neurodevelopmental Phenotypes

Author

Verheyen, An, primary, Diels, Annick, additional, Reumers, Joke, additional, Van Hoorde, Kirsten, additional, Van den Wyngaert, Ilse, additional, van Outryve d’Ydewalle, Constantin, additional, De Bondt, An, additional, Kuijlaars, Jacobine, additional, De Muynck, Louis, additional, De Hoogt, Ronald, additional, Bretteville, Alexis, additional, Jaensch, Steffen, additional, Buist, Arjan, additional, Cabrera-Socorro, Alfredo, additional, Wray, Selina, additional, Ebneth, Andreas, additional, Roevens, Peter, additional, Royaux, Ines, additional, and Peeters, Pieter J., additional

Published
2018
Full Text
View/download PDF

21. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Celbiologie, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Celbiologie, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

22. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

Cell Biology, Neurobiology and Biophysics, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., Ruigrok, Ynte M., Cell Biology, Neurobiology and Biophysics, Sub Cell Biology, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W. Berkelbach, Han, K. Sen, Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J.E., Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

23. RNA Sequencing Analysis of Intracranial Aneurysm Walls Reveals Involvement of Lysosomes and Immunoglobulins in Rupture

Author

ZL Cerebrovasculaire Ziekten Medisch, Brain, Neurogenetica, ZL Algemene en Acute Nec Medisch, Opleiding Neurochirurgie, Zorglijn FNE Medisch, Neurologie, Circulatory Health, Hersenen-Medisch 2, ZL Neuromusculaire Ziekten Medisch, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W Berkelbach, Sen Han, K., Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J E, Veldink, Jan H., Ruigrok, Ynte M., ZL Cerebrovasculaire Ziekten Medisch, Brain, Neurogenetica, ZL Algemene en Acute Nec Medisch, Opleiding Neurochirurgie, Zorglijn FNE Medisch, Neurologie, Circulatory Health, Hersenen-Medisch 2, ZL Neuromusculaire Ziekten Medisch, Kleinloog, Rachel, Verweij, Bon H., Van Der Vlies, Pieter, Deelen, Patrick, Swertz, Morris A., De Muynck, Louis, Van Damme, Philip, Giuliani, Fabrizio, Regli, Luca, Van Der Zwan, Albert, Van Der Sprenkel, Jan W Berkelbach, Sen Han, K., Gosselaar, Peter, Van Rijen, Peter C., Korkmaz, Emine, Post, Jan A., Rinkel, Gabriel J E, Veldink, Jan H., and Ruigrok, Ynte M.

Published
2016

24. Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations

Author

Dooley, James, primary, Pauwels, Ine, additional, Franckaert, Dean, additional, Smets, Ide, additional, Garcia-Perez, Josselyn E., additional, Hilven, Kelly, additional, Danso-Abeam, Dina, additional, Terbeek, Joanne, additional, Nguyen, Anh T.L., additional, De Muynck, Louis, additional, Decallonne, Brigitte, additional, Dubois, Bénédicte, additional, Liston, Adrian, additional, and Goris, An, additional

Published
2016
Full Text
View/download PDF

25. Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia

Author

Raitano, Susanna, Ordovàs, Laura, Geraerts, Martine, Khurana, Satish, Vanuytsel, Kim, Verfaillie, Catherine, De Muynck, Louis, Guo, Wenting, Vandenberghe, Rik, Van Den Bosch, Ludo, Van Damme, Philip, Espuny Camacho, Ira Mercedes, Vanderhaeghen, Pierre, Tóth, Balázs, Voets, Thomas, Cathomen, Toni, Raitano, Susanna, Ordovàs, Laura, Geraerts, Martine, Khurana, Satish, Vanuytsel, Kim, Verfaillie, Catherine, De Muynck, Louis, Guo, Wenting, Vandenberghe, Rik, Van Den Bosch, Ludo, Van Damme, Philip, Espuny Camacho, Ira Mercedes, Vanderhaeghen, Pierre, Tóth, Balázs, Voets, Thomas, and Cathomen, Toni

Abstract

To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRNIVS1+5G > C mutation (FTD-iPSCs). FTD-iPSCs were fated to cortical neurons, the cells most affected in FTD. Although generation of neuroprogenitors was unaffected, their further differentiation into CTIP2-, FOXP2-, or TBR1-TUJ1 double-positive cortical neurons, but not motorneurons, was significantly decreased in FTD-neural progeny. Zinc finger nuclease-mediated introduction of GRN cDNA into the AAVS1 locus corrected defects in cortical neurogenesis, demonstrating that PGRN haploinsufficiency causes inefficient cortical neuron generation. RNA sequencing analysis confirmed reversal of the altered gene expression profile following genetic correction. We identified the Wnt signaling pathway as one of the top defective pathways in FTD-iPSC-derived neurons, which was reversed following genetic correction. Differentiation of FTD-iPSCs in the presence of a WNT inhibitor mitigated defective corticogenesis. Therefore, we demonstrate that PGRN haploinsufficiency hampers corticogenesis in vitro., SCOPUS: ar.j, info:eu-repo/semantics/published

Published
2015

26. Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia

Author

Raitano, Susanna, primary, Ordovàs, Laura, additional, De Muynck, Louis, additional, Guo, Wenting, additional, Espuny-Camacho, Ira, additional, Geraerts, Martine, additional, Khurana, Satish, additional, Vanuytsel, Kim, additional, Tóth, Balazs I., additional, Voets, Thomas, additional, Vandenberghe, Rik, additional, Cathomen, Toni, additional, Van Den Bosch, Ludo, additional, Vanderhaeghen, Pierre, additional, Van Damme, Philip, additional, and Verfaillie, Catherine M., additional

Published
2015
Full Text
View/download PDF

28. Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations.

Author

Dooley J, Pauwels I, Franckaert D, Smets I, Garcia-Perez JE, Hilven K, Danso-Abeam D, Terbeek J, Nguyen AT, De Muynck L, Decallonne B, Dubois B, Liston A, and Goris A

Abstract

Objective: We undertook a systems immunology approach of the adaptive immune system in multiple sclerosis (MS), overcoming tradeoffs between scale and level of detail, in order to identify the immunologic signature of MS and the changes wrought by current immunomodulatory treatments., Methods: We developed a comprehensive flow cytometry platform measuring 38 immunologic cell types in the peripheral blood of 245 individuals in a routine clinical setting. These include patients with MS, untreated or receiving any of 4 current immunomodulatory treatments (interferon-β, glatiramer acetate, natalizumab, or fingolimod), patients with autoimmune thyroid disease, and healthy controls., Results: An increase in memory CD8(+) T cells and B cells was observed in untreated patients with MS. Interferon-β and fingolimod induce significant changes upon multiple aspects of the peripheral immune system, with an unexpectedly prominent alteration of B cells. Overall, both treatments push the immune system in different directions, with only 2 significant effects shared across these treatments-an increase in transitional B cells and a decrease in class-switched B cells. We further identified heightened B cell-activating factor (BAFF) levels as regulating this shared B cell pathway., Conclusions: A systems immunology approach established different immunologic profiles induced by current immunomodulatory MS treatments, offering perspectives for personalized medicine. Pathways shared between the immunologic architecture of existing efficacious treatments identify targets for future treatment design.

Published
2016
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results