390 results on '"De Nigris F"'
Search Results
2. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study
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Amitrano, L, Anderloni, A, Andriulli, A, Annese, V, Baldassarre, G, Bargiggia, S, Bazzoli, F, Bennato, R, Bianco, MA, Bizzotto, A, Boarino, V, Bonanomi, AG, Borgheresi, P, Bresci, G, Buffoli, F, Buscarini, E, Castrignanò, G, Cavallaro, LG, Cesaro, P, Chirico, A, Cipolletta, F, Cipolletta, L, Conigliaro, R, Conte, D, Costamagna, G, Covello, F, D'Amico, G, De-Fanis, C, De-Filippo, FR, de-Franchis, R, Dell‘Era, A, De Nigris, F, De-Matthaeis, M, Di-Giorgio, P, Di-Giulio, E, Esposito, P, Ferraris, L, Filippino, A, Franceschi, M, Furio, L, Germana', B, Grassia, R, Imperiali, G, Lamanda, R, Lauri, A, Londoni, C, Mangiafico, S, Manno, M, Marmo, C, Merighi, A, Meroni, R., Metrangolo, S, Montalbano, LM, Napolitano, G, Nucci, A, Orsini, L, Parente, F, Parravicini, M, Paterlini, A, Pumpo, R, Purita, L, Repici, A, Riccioni, ME, Russo, A, Segato, S, Sorrentino, I, Spinzi, G, Spotti, D, Tortora, A, Tomba, C, Triossi, O, Zagari, RM, Zambelli, A, Marmo, Riccardo, Soncini, Marco, Bucci, Cristina, and Zullo, Angelo
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- 2021
- Full Text
- View/download PDF
3. Therapeutic targeting of P2X4 receptor and mitochondrial metabolism in clear cell renal carcinoma models
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Rupert C., Dell' Aversana C., Mosca L., Montanaro V., Arcaniolo D., De Sio M., Bilancio A., Altucci L., Palinski W., Pili R., de Nigris F., Rupert, Christofer, Aversana, Carmela Dell', Mosca, Laura, Montanaro, Vittorino, Arcaniolo, Davide, De Sio, Marco, Bilancio, Antonio, Altucci, Lucia, Palinski, Wulf, Pili, Roberto, de Nigris, Filomena, Rupert, C., Dell' Aversana, C., Mosca, L., Montanaro, V., Arcaniolo, D., De Sio, M., Bilancio, A., Altucci, L., Palinski, W., Pili, R., and de Nigris, F.
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Organoid ,Cancer Research ,Kidney Disease ,Oncology and Carcinogenesis ,Cell Line ,Mice ,Renal carcinoma ,Receptors ,Animals ,Humans ,2.1 Biological and endogenous factors ,Oncology & Carcinogenesis ,Aetiology ,Cancer ,Tumor ,Carcinoma ,Renal Cell ,Lysosome ,Kidney Neoplasms ,Mitochondria ,Organoids ,Drug screening ,Oncology ,5.1 Pharmaceuticals ,Purinergic P2X4 ,Calcium ,Purinergic receptors ,Development of treatments and therapeutic interventions ,Lysosomes ,Purinergic receptor - Abstract
Background Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. Large-scale metabolomic data have associated metabolic alterations with the pathogenesis and progression of renal carcinoma and have correlated mitochondrial activity with poor survival in a subset of patients. The aim of this study was to determine whether targeting mitochondria-lysosome interaction could be a novel therapeutic approach using patient-derived organoids as avatar for drug response. Methods RNAseq data analysis and immunohistochemistry were used to show overexpression of Purinergic receptor 4 (P2XR4) in clear cell carcinomas. Seahorse experiments, immunofluorescence and fluorescence cell sorting were used to demonstrate that P2XR4 regulates mitochondrial activity and the balance of radical oxygen species. Pharmacological inhibitors and genetic silencing promoted lysosomal damage, calcium overload in mitochondria and cell death via both necrosis and apoptosis. Finally, we established patient-derived organoids and murine xenograft models to investigate the antitumor effect of P2XR4 inhibition using imaging drug screening, viability assay and immunohistochemistry. Results Our data suggest that oxo-phosphorylation is the main source of tumor-derived ATP in a subset of ccRCC cells expressing P2XR4, which exerts a critical impact on tumor energy metabolism and mitochondrial activity. Prolonged mitochondrial failure induced by pharmacological inhibition or P2XR4 silencing was associated with increased oxygen radical species, changes in mitochondrial permeability (i.e., opening of the transition pore complex, dissipation of membrane potential, and calcium overload). Interestingly, higher mitochondrial activity in patient derived organoids was associated with greater sensitivity to P2XR4 inhibition and tumor reduction in a xenograft model. Conclusion Overall, our results suggest that the perturbed balance between lysosomal integrity and mitochondrial activity induced by P2XR4 inhibition may represent a new therapeutic strategy for a subset of patients with renal carcinoma and that individualized organoids may be help to predict drug efficacy.
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- 2023
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- View/download PDF
4. Maternal hypercholesterolemia during pregnancy promotes early atherogenesis in LDL receptor-deficient mice and alters aortic gene expression determined by microarray
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Napoli, C, de Nigris, F, Welch, JS, Calara, FB, Stuart, RO, Glass, CK, and Palinski, W
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atherosclerosis ,genes ,microarray ,pathology ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services - Published
- 2002
5. Age-Related Effects on Atherogenesis and Scavenger Enzymes of Intracranial and Extracranial Arteries in Men Without Classic Risk Factors for Atherosclerosis
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D'Armiento, FP, Bianchi, A, de Nigris, F, Capuzzi, DM, D'Armiento, MR, Crimi, G, Abete, P, Palinski, W, Condorelli, M, Napoli, C, and Gronholdt, M-LM
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Biomedical and Clinical Sciences ,Neurosciences ,Clinical Sciences ,Atherosclerosis ,Prevention ,Cardiovascular ,Clinical Research ,Aging ,Heart Disease ,Aetiology ,2.1 Biological and endogenous factors ,Adult ,Age Factors ,Aged ,Antioxidants ,Apolipoproteins B ,Arteries ,Cerebral Arteries ,Child ,Disease Progression ,Humans ,Immunohistochemistry ,Intracranial Arteriosclerosis ,Lipid Peroxidation ,Lipoproteins ,LDL ,Male ,Matrix Metalloproteinase 9 ,Retrospective Studies ,Risk Factors ,Superoxide Dismutase ,atherosclerosis ,cerebral arteries ,lipoproteins ,LDL ,oxygen radical ,Cardiorespiratory Medicine and Haematology ,Neurology & Neurosurgery ,Clinical sciences ,Allied health and rehabilitation science - Abstract
Background and purposeAtherosclerosis occurs later and is less extensive in intracranial arteries than in extracranial arteries. However, the mechanisms responsible are poorly understood. A previous study has suggested a better antioxidant protection of intracranial arteries.MethodsTo assess the influence of age on arterial activity of antioxidant enzymes and atherogenesis, we compared intracranial and extracranial arteries of humans of different ages who retrospectively lacked confounding classic risk factors (48 premature fetuses aged 6.4+/-0.8 months [mean+/-SD], 58 children aged 7.9+/-3.8 years, 42 adults aged 42.5+/-5.1 years, and 40 elderly subjects aged 71.8+/-3.4 years; all males). Lesions were quantified by computer-assisted imaging analysis of sections of the middle cerebral and basilar arteries, the left anterior descending coronary artery, the common carotid artery, and the abdominal aorta. Macrophages, apolipoprotein B, oxidized LDL, and matrix metalloproteinase-9 in lesions were determined by immunocytochemistry. The effect of aging on atherogenesis was then compared with that on the activity of 4 antioxidant enzymes in the arterial wall.ResultsAtherosclerosis was 6- to 19-fold greater (P
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- 2001
6. Maternal hypercholesterolemia and treatment during pregnancy influence the long-term progression of atherosclerosis in offspring of rabbits.
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Palinski, W, D'Armiento, FP, Witztum, JL, de Nigris, F, Casanada, F, Condorelli, M, Silvestre, M, and Napoli, C
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Aorta ,Animals ,Rabbits ,Aortic Diseases ,Arteriosclerosis ,Hypercholesterolemia ,Disease Progression ,Malondialdehyde ,Vitamin E ,Linoleic Acid ,Anticholesteremic Agents ,Antioxidants ,Lipid Peroxidation ,Pregnancy ,Female ,Cholestyramine Resin ,pathogenesis ,fetus ,oxidation ,vitamin E ,cholestyramine ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences - Abstract
Maternal hypercholesterolemia during pregnancy is associated with enhanced fatty streak formation in human fetuses and faster progression of atherosclerosis during childhood even under normocholesterolemic conditions. A causal role of maternal hypercholesterolemia in lesion formation during fetal development has previously been established in rabbits. The same experimental model is now used to establish that maternal hypercholesterolemia or ensuing pathogenic events in fetal arteries enhance atherogenesis later in life. Five groups of rabbit mothers were fed chow, cholesterol-enriched chow, or cholesterol-enriched chow plus 1000 IU vitamin E, 3% cholestyramine, or both during pregnancy. Offspring of all groups (n=136) were fed a mildly hypercholesterolemic diet for up to a year and had similar cholesterol levels. Aortic lesion sizes and lipid peroxidation products in plasma and lesions in offspring were determined at birth, 6 months, or 12 months. Lesion progression in offspring of hypercholesterolemic mothers was greater than in all other groups. At each time point, offspring of hypercholesterolemic mothers had 1.5- to 3-fold larger lesions than offspring of normocholesterolemic mothers (P
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- 2001
7. Maternal hypercholesterolemia enhances atherogenesis in normocholesterolemic rabbits, which is inhibited by antioxidant or lipid-lowering intervention during pregnancy: an experimental model of atherogenic mechanisms in human fetuses.
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Napoli, C, Witztum, JL, Calara, F, de Nigris, F, and Palinski, W
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Aorta ,Fetus ,Animals ,Rabbits ,Pregnancy Complications ,Prenatal Exposure Delayed Effects ,Arteriosclerosis ,Hypercholesterolemia ,Vitamin E ,Cholesterol ,Cholesterol ,Dietary ,Fatty Acids ,Triglycerides ,Antioxidants ,Remission Induction ,Diet ,Atherogenic ,Lipid Peroxidation ,Pregnancy ,Female ,Cholestyramine Resin ,atherosclerosis ,cholestyramine ,vitamin E ,oxidation ,prevention ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Cardiovascular System & Hematology - Abstract
Maternal hypercholesterolemia during pregnancy is associated with a marked increase in aortic fatty streak formation in human fetuses and faster progression of atherosclerosis during normocholesterolemic childhood. However, the mechanisms responsible are unknown, and the contribution of genetic differences is difficult to assess in humans. The goal of this study was to determine whether maternal hypercholesterolemia per se may cause enhanced fatty streak formation in offspring and whether interventions during pregnancy can reduce it. During pregnancy, 1 group of New Zealand White rabbits was fed control chow and 8 groups were fed hypercholesterolemic diets Chol 1 (yielding plasma cholesterol of 153 mg/dL) or Chol 2 (yielding 359 mg/dL) without or with cholestyramine, vitamin E, or both. Offspring (n=15 to 25 per group) were killed at birth. Maternal hypercholesterolemia enhanced mean lesion size in the aorta of their offspring at birth from 44+/-18x10(3) micrometer(2) per section in controls to 85+/-26x10(3) in Chol 1 and 156+/-49x10(3) in Chol 2 groups (P
- Published
- 2000
8. Mildly oxidized low density lipoprotein activates multiple apoptotic signaling pathways in human coronary cells.
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Napoli, C, Quehenberger, O, De Nigris, F, Abete, P, Glass, CK, and Palinski, W
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Muscle ,Smooth ,Vascular ,Coronary Vessels ,Endothelium ,Vascular ,Humans ,Arteriosclerosis ,Caspases ,Mitogen-Activated Protein Kinases ,JNK Mitogen-Activated Protein Kinases ,Lipoproteins ,LDL ,NF-kappa B ,Receptors ,Tumor Necrosis Factor ,Transcription Factor AP-1 ,Signal Transduction ,Apoptosis ,Enzyme Activation ,Oxidation-Reduction ,Genes ,bcl-2 ,fas Receptor ,oxidized LDL ,atherosclerosis ,FasL ,TNF receptors ,caspases ,MAPK ,JunK ,Biochemistry & Molecular Biology ,Biochemistry and Cell Biology ,Physiology ,Medical Physiology - Abstract
Apoptosis of arterial cells induced by oxidized low density lipoproteins (OxLDL) is thought to contribute to the progression of atherosclerosis. However, most data on apoptotic effects and mechanisms of OxLDL were obtained with extensively oxidized LDL unlikely to occur in early stages of atherosclerotic lesions. We now demonstrate that mildly oxidized LDL generated by incubation with oxygen radical-producing xanthine/xanthine oxidase (X/XO) induces apoptosis in primary cultures of human coronary endothelial and SMC, as determined by TUNEL technique, DNA laddering, and FACS analysis. Apoptosis was markedly reduced when X/XO-LDL was generated in the presence of different oxygen radical scavengers. Apoptotic signals were mediated by intramembrane domains of both Fas and tumor necrosis factor (TNF) receptors I and II. Blocking of Fas ligand (FasL) reduced apoptosis by 50% and simultaneous blocking of FasL and TNF receptors by 70%. Activation of apoptotic receptors was accompanied by an increase of proapoptotic and a decrease in antiapoptotic proteins of the Bcl-2 family and resulted in marked activation of class I and II caspases. Mildly oxidized LDL also activated MAP and Jun kinases and increased p53 and other transcription factors (ATF-2, ELK-1, CREB, AP-1). Inhibitors of Map and Jun kinase significantly reduced apoptosis. Our results provide the first evidence that OxLDL-induced apoptosis involves TNF receptors and Jun activation. More important, they demonstrate that even mildly oxidized LDL formed in atherosclerotic lesions may activate a broad cascade of oxygen radical-sensitive signaling pathways affecting apoptosis and other processes influencing the evolution of plaques. Thus, we suggest that extensive oxidative modifications of LDL are not necessary to influence signal transduction and transcription in vivo.
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- 2000
9. Evidence for oxidative activation of c-Myc-dependent nuclear signaling in human coronary smooth muscle cells and in early lesions of Watanabe heritable hyperlipidemic rabbits: protective effects of vitamin E.
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de Nigris, F, Youssef, T, Ciafré, S, Franconi, F, Anania, V, Condorelli, G, Palinski, W, and Napoli, C
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Muscle ,Smooth ,Vascular ,Cells ,Cultured ,Animals ,Rabbits ,Humans ,Vitamin E ,Lipoproteins ,LDL ,Carrier Proteins ,Cell Cycle Proteins ,DNA-Binding Proteins ,Proto-Oncogene Proteins c-myc ,Transcription Factors ,Signal Transduction ,Oxidation-Reduction ,Transcription Factor DP1 ,E2F Transcription Factors ,Basic-Leucine Zipper Transcription Factors ,Kruppel-Like Transcription Factors ,Basic Helix-Loop-Helix Leucine Zipper Transcription Factors ,Hyperlipidemias ,Retinoblastoma-Binding Protein 1 ,lipoproteins ,coronary disease ,antioxidants ,atherosclerosis ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services - Abstract
BackgroundOxidized LDL (oxLDL) promotes atherogenesis, and antioxidants reduce lesions in experimental models. OxLDL-mediated effects on c-Myc are poorly characterized, and those on c-Myc nuclear pathways are completely unknown. c-Myc stimulates smooth muscle cell (SMC) proliferation and could be involved in atherosclerosis. We investigated the early effects of oxLDL and alpha-tocopherol on c-Myc, its binding partner Max, and the carboxy-terminal domain-binding factors activator protein-2 and elongation 2 factor in human coronary SMCs. We also investigated whether 9-week treatment of Watanabe heritable hyperlipidemic (WHHL) rabbits with diet-enriched alpha-tocopherol reduces c-Myc expression and oxLDL in the left coronary artery.Methods and resultsOxLDL enhanced c-Myc/Max expression and transcription by cotransfection assay and the nuclear activities of E2F and activator protein-2 by binding shift and supershift in coronary SMCs. alpha-Tocopherol significantly reduced these molecular events. Furthermore, alpha-tocopherol reduced early lesions, SMC density, and the immunohistochemical presence of c-Myc, which colocalized with oxLDL/foam cells in the coronaries of WHHL rabbits.ConclusionsWe provide the first evidence that oxLDL and alpha-tocopherol may influence c-Myc activation and several c-Myc-dependent signaling pathways in human coronary SMCs. The observation that in vivo, an antioxidant reduces both c-Myc and oxLDL in early coronary lesions of rabbits is consistent with, but does not prove, the hypothesis that c-Myc-dependent factors activated by oxidative processes contribute to atherogenesis and coronary heart disease.
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- 2000
10. 1,4-Dihydropyridine calcium channel blockers inhibit plasma and LDL oxidation and formation of oxidation-specific epitopes in the arterial wall and prolong survival in stroke-prone spontaneously hypertensive rats.
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Napoli, C, Salomone, S, Godfraind, T, Palinski, W, Capuzzi, DM, Palumbo, G, D'Armiento, FP, Donzelli, R, de Nigris, F, Capizzi, RL, Mancini, M, Gonnella, JS, and Bianchi, A
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Arteries ,Animals ,Rats ,Inbred SHR ,Rats ,Inbred WKY ,Rats ,Cerebrovascular Disorders ,Genetic Predisposition to Disease ,Dihydropyridines ,Vitamin E ,Lipoproteins ,LDL ,Apolipoproteins B ,Calcium Channel Blockers ,Epitopes ,Antioxidants ,Immunohistochemistry ,Oxidation-Reduction ,Reference Values ,Male ,atherosclerosis ,calcium channel blockers ,lipoproteins ,LDL ,oxygen radical ,stroke ,Neurology & Neurosurgery ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Neurosciences - Abstract
Background and purposeCalcium-channel blockers (CCBs) reduce systolic blood pressure and stroke-related mortality in stroke-prone spontaneously hypertensive rats (SPSHR). Brain ischemia is associated with loss of intracellular antioxidants. Increased formation of oxygen radicals and oxidation of LDL may enhance arterial vasoconstriction by various mechanisms. CCBs that also exert antioxidative properties in vitro may therefore be particularly useful. To investigate such antioxidant effects in vivo, we determined several parameters of LDL oxidation in SPSHR treated with two 1,4-dihydropyridine-type (1,4-DHP) CCBs of different lipophilic properties and compared them with antioxidant-treated and untreated controls. We also tested whether these drugs decrease the formation of oxidation-specific epitopes in arteries.MethodsFive groups of 9 to 14 SPSHR each (aged 8 weeks) were treated with 80 mg/kg body wt per day nifedipine, 1 mg or 0.3 mg/kg body wt per day lacidipine, vitamin E (100 IU/d), or carrier for 5 weeks. A group of Wistar-Kyoto rats was used as normotensive control. Plasma samples were taken, and LDL was isolated by ultracentrifugation. Then LDL was exposed to oxygen radicals generated by xanthine/xanthine oxidase reaction (2 mmol/L xanthine+100 mU/mL xanthine oxidase), and several parameters of oxidation were determined. The presence of native apolipoprotein B and oxidation-specific epitopes in the carotid and middle cerebral arteries was determined immunocytochemically.Results1,4-DHP CCBs completely prevented mortality. Normotensive Wistar-Kyoto rats showed less oxidation than control SPSHR. Plasma lipoperoxide levels were 0.87+/-0.27 micromol/L in control SPSHR, 0.69+/-0.19 and 0.63+/-0.20 micromol/L in the groups treated with 0.3 and 1 mg lacidipine, respectively, and 0.68+/-0.23 micromol/L in nifedipine-treated animals (P
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- 1999
11. Intracranial arteries of human fetuses are more resistant to hypercholesterolemia-induced fatty streak formation than extracranial arteries.
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Napoli, C, Witztum, JL, de Nigris, F, Palumbo, G, D'Armiento, FP, and Palinski, W
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Aorta ,Abdominal ,Carotid Artery ,Common ,Cerebral Arteries ,Humans ,Pregnancy Complications ,Abortion ,Spontaneous ,Fetal Diseases ,Arteriosclerosis ,Hypercholesterolemia ,Free Radicals ,Catalase ,Glutathione Peroxidase ,Superoxide Dismutase ,Lipids ,Organ Specificity ,Lipid Peroxidation ,Gestational Age ,Pregnancy ,Adult ,Infant ,Newborn ,Infant ,Premature ,Female ,Male ,Immunity ,Innate ,atherosclerosis ,hypercholesterolemia ,lipoproteins ,brain ,stroke ,free radicals ,Cardiovascular System & Hematology ,Cardiorespiratory Medicine and Haematology ,Clinical Sciences ,Public Health and Health Services - Abstract
BackgroundAtherosclerotic lesions in intracranial arteries occur later and are less extensive than in extracranial arteries. To investigate potential mechanisms responsible for this difference, in particular the atherogenic response to hypercholesterolemia and LDL oxidation, we compared the extent of fatty streak formation and the composition of these very early lesions in intracranial arteries of human fetuses from normocholesterolemic and hypercholesterolemic mothers with those in extracranial arteries.Methods and resultsLesions were quantified by computer-assisted image analysis of 30 oil red O-stained sections, each from the middle cerebral, basilar, and common carotid arteries and the abdominal aorta of human fetuses (spontaneous abortions and premature newborns who died within 12 hours of birth; both of fetal age 6.2+/-1.3 months) from 43 hypercholesterolemic mothers and 34 normocholesterolemic mothers. Macrophages, apolipoprotein B, and 2 epitopes of oxidized LDL in lesions were determined immunocytochemically. Activities of superoxide dismutase, catalase, and glutathione peroxidase in the arterial wall were also determined. Lesion numbers and sizes were dramatically greater in the abdominal aorta (area of the largest lesion per section: 66.5+/-10.9 x10(3) microm2) and the carotid (11. 6+/-5.3 x10(3) microm2) than in the basilar and middle cerebral artery (0.4+/-0.1 and 0.8+/-0.2 x10(3) microm2, respectively; P
- Published
- 1999
12. Long-Term Results of Complex Abdominal Aortic Aneurysm Open Repair
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Tshomba, Yamume, Sica, Simona, Minelli, Fabrizio, Ferraresi, M., De Waure, Chiara, Donati, Tommaso, De Nigris, Francesca, Vincenzoni, Claudio, Snider, Francesco, Tinelli, Giovanni, Tshomba Y. (ORCID:0000-0001-7304-7553), Sica S., Minelli F., de Waure C. (ORCID:0000-0002-4346-1494), Donati T. (ORCID:0000-0002-4484-2176), De Nigris F., Vincenzoni C., Snider F. (ORCID:0000-0002-8102-7015), Tinelli G. (ORCID:0000-0002-2212-3226), Tshomba, Yamume, Sica, Simona, Minelli, Fabrizio, Ferraresi, M., De Waure, Chiara, Donati, Tommaso, De Nigris, Francesca, Vincenzoni, Claudio, Snider, Francesco, Tinelli, Giovanni, Tshomba Y. (ORCID:0000-0001-7304-7553), Sica S., Minelli F., de Waure C. (ORCID:0000-0002-4346-1494), Donati T. (ORCID:0000-0002-4484-2176), De Nigris F., Vincenzoni C., Snider F. (ORCID:0000-0002-8102-7015), and Tinelli G. (ORCID:0000-0002-2212-3226)
- Abstract
This study investigated the long-term outcomes of patients treated with open surgical repair for complex abdominal aortic aneurysms (c-AAAs). A total of 119 patients with c-AAAs undergoing repair between January 2010 and June 2016 in a high-volume aortic center were included. The long-term imaging follow-up consisted of yearly abdominal ultrasound examinations and 5-year computed tomography angiography. At a median follow-up of 76 months (IQR 38 months), forty-three deaths (37%) and three (2.5%) aortic-related deaths were observed. Long-term chronic renal decline was observed in fifty (43.8%) patients, significantly correlated with post-operative acute kidney injury. During the follow-up, five reinterventions (4.3%) were performed. The present study suggests that open c-AAA repair can be performed with acceptable operative risk with durable results. To achieve the best possible long-term outcome, the open surgery repair of complex AAA should be performed in high-volume aortic centers and tailored to the patient.
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- 2022
13. Type 1A Endoleak after TEVAR in the Aortic Arch: A Review of the Literature
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Scurto, Lucia, Peluso, Nicolo', Pascucci, Federico, Sica, Simona, De Nigris, Francesca, Filipponi, M., Minelli, Fabrizio, Donati, Tommaso, Tinelli, Giovanni, Tshomba, Yamume, Scurto L., Peluso N., Pascucci F., Sica S., De Nigris F., Minelli F., Donati T. (ORCID:0000-0002-4484-2176), Tinelli G. (ORCID:0000-0002-2212-3226), Tshomba Y. (ORCID:0000-0001-7304-7553), Scurto, Lucia, Peluso, Nicolo', Pascucci, Federico, Sica, Simona, De Nigris, Francesca, Filipponi, M., Minelli, Fabrizio, Donati, Tommaso, Tinelli, Giovanni, Tshomba, Yamume, Scurto L., Peluso N., Pascucci F., Sica S., De Nigris F., Minelli F., Donati T. (ORCID:0000-0002-4484-2176), Tinelli G. (ORCID:0000-0002-2212-3226), and Tshomba Y. (ORCID:0000-0001-7304-7553)
- Abstract
Aortic arch repair is a challenging intervention. Open surgical repair is still considered the gold standard, but in high-risk patients, it is not always a reasonable option, making endovascular approaches an enticing, when not the only available, alternative for treatment. The strategies more commonly adopted are surgical supra-aortic trunk (SAT) rerouting followed by deployment of a standard thoracic endoprosthesis, chimney techniques, custom-made scalloped, fenestrated, and branched devices, and in situ or physician-modified fenestrations. If we excluded techniques involving SAT rerouting where the arch anatomy is surgically modified in order to make deployment in the aortic arch of a standard thoracic endoprosthesis possible, in the other techniques, one or more SATs are incorporated in the thoracic endoprosthesis. In these cases, no matter what solution is adopted, because of the morphology of the aorta at this level, achieving an ideal sealing is extremely difficult, and endovascular treatments of the arch are burdened by an increased risk of type IA endoleaks. PubMed, EMBASE, and Cochrane Library were searched. We identified 1277 records. After reading titles, abstracts, and full texts, we excluded 1231 records. Exclusion criteria were low-quality evidence, abstracts, case reports, conference presentations, reviews, editorials, and expert opinions. A total of 48 studies were included, for a total of 3114 patients. A type IA endoleak occurred in 248 patients (7.7%) with a mean incidence of 18.8% in chimney procedures, 4.8% and 3%, respectively, in fenestrated and branched devices, and 2.2% in in situ fenestration. We excluded from our analysis scalloped technology that is used when the target vessel originates from a healthy landing zone and represents a different anatomical setting. Type IA endoleaks are a concern with all types of endovascular aortic arch repair, and they can compromise the outcomes of the procedure. The rate of type IA endoleaks appears to
- Published
- 2022
14. DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas
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Schiano C, D'Armiento M, Franzese M, Castaldo R, Saccone G, de Nigris F, Grimaldi V, Soricelli A, D'Armiento FP, Zullo F, Napoli C., Schiano, C, D'Armiento, M, Franzese, M, Castaldo, R, Saccone, G, de Nigris, F, Grimaldi, V, Soricelli, A, D'Armiento, Fp, Zullo, F, and Napoli, C.
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Hypercholesterolemia ,Gene Expression Regulation, Developmental ,Gestational Age ,DNA Methylation ,SREBF2 ,Epigenesis, Genetic ,Pregnancy Complications ,Epigenome ,Cholesterol ,Dyslipidemia ,Pregnancy ,Atherosclerosi ,Case-Control Studies ,Humans ,Female ,Gene Regulatory Networks ,Fetu ,Protein Interaction Maps ,Aorta ,Biomarkers ,Sterol Regulatory Element Binding Protein 2 - Abstract
Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human fetal aorta samples were collected from the spontaneously aborted fetuses of normalcholesterolemic and hypercholesterolemic mothers. Maternal total cholesterol levels were assessed during hospitalization. DNA methylation profiling of the whole SREBF2 gene CpG island was performed (p-value
- Published
- 2021
15. DNA Methylation Profile of the SREBF2 Gene in Human Fetal Aortas
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Schiano, C., D'Armiento, M., Franzese, M., Castaldo, R., Saccone, G., De Nigris, F., Grimaldi, V., Soricelli, A., D'Armiento, F. P., Zullo, F., Napoli, C., Schiano, Concetta, D'Armiento, Maria, Franzese, Monica, Castaldo, Rossana, Saccone, Gabriele, de Nigris, Filomena, Grimaldi, Vincenzo, Soricelli, Andrea, D'Armiento, Francesco Paolo, Zullo, Fulvio, Napoli, Claudio, Schiano, C, D'Armiento, M, Franzese, M, Castaldo, R, Saccone, G, de Nigris, F, Grimaldi, V, Soricelli, A, D'Armiento, Fp, Zullo, F, and Napoli, C
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Fetus ,Cholesterol ,Dyslipidemia ,Atherosclerosi ,Fetu ,Atherosclerosis ,SREBF2 ,Aorta ,Aortas - Abstract
Increasing evidence suggests that maternal cholesterol represents an important risk factor for atherosclerotic disease in offspring already during pregnancy, although the underlying mechanisms have not yet been elucidated. Eighteen human fetal aorta samples were collected from the spontaneously aborted fetuses of normal cholesterolemic and hypercholesterolemic mothers. Maternal total cholesterol levels were assessed during hospitalization. DNA methylation profiling of the whole SREBF2 gene CpG island was performed (p value
- Published
- 2021
16. Derivation and validation of Re.Co.De death score risk in patients with acute nonvariceal upper GI bleeding
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Riccardo Marmo, Marco Soncini, Cristina Bucci, Vincenzo Occhipinti, Lucienne Pellegrini, Angelo Zullo, Amitrano L, Andriulli A, Annese V, Baldassarre G, Bargiggia S, Balzano A, Bazzoli F, Bennato R, Bianco M A, Bizzotto A, Boarino V, Bonanomi AG, Borgheresi P, Bresci G, Buffoli F, Buscarini E, Castrignanò G, Cavallaro LG, Cesaro P, Chirico A, Cipolletta F, Cipolletta L, Conigliaro R, Conte D, Costamagna G, D’ Amico G, De Fanis C, De Filippo FR, de Franchis R, Dell‘ Era A, De Nigris F, De Matthaeis M, Di Giorgio P, Di Giulio E, Esposito P, Ferraris L, Filippino A, Franceschi M, Furio L, Germana B, Grassia R, Imperiali G, Lamanda R, Lauri A, Londoni C, Mangiafico S, Manno M, Marmo C, Meroni R, Metrangolo S, Montalbano L. M, Napolitano G, Nucci A, Orsini L, Parente F, Parravicini M, Paterlini A, Pumpo R, Purita L, Repici A, Riccioni ME, Russo A, Segato S, Sorrentino I, Spinzi G, Spotti D, Tortora A, Triossi O, Zagari RM, and Zambelli A
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Cohort Studies ,Area Under Curve ,Acute Disease ,Gastroenterology ,Humans ,Radiology, Nuclear Medicine and imaging ,Gastrointestinal Hemorrhage ,Prognosis ,Risk Assessment ,Severity of Illness Index - Abstract
Scores in upper GI bleeding (UGIB) are used to stratify death risk and need for hospitalization at admission, but a tool that incorporates dynamic changes during the hospital stay is lacking. We aimed to develop a death risk score that considers changes in clinical status during hospitalization and compare its performance with existing ones.A multicenter cohort study enrolling patients with UGIB in 50 Italian hospitals from January 2014 to December 2015 was conducted. Data were collected and used to develop a risk score using logistic regression analyses. Performance curves (area under the receiver-operating characteristic [AUROC] curves), sensitivities, specificities, positive and negative predictive values, and outcomes classified as low, intermediate, and high death risk were calculated. The score's performance was externally validated and then compared with other scores.We included 1852 patients with nonvariceal UGIB in the development cohort and 912 in the validation cohorts. The new score, which we named the Re.Co.De (rebleeding-comorbidities-deteriorating) score, included 10 variables depicting the changes in clinical conditions while in the hospital. The mortality AUROC curves were .93 (95% confidence interval, .91-.96) in the derivation cohort and .94 (95% confidence interval, .91-.98) in validation cohort. In a comparison of AUROC curves with other scores, the new score showed a significant performance compared with pre- and postendoscopy scores. Patients with low and high scores had 30-day mortality rates of .001% and 48.2%, respectively.The Re.Co.De score has a higher performance for predicting mortality in patients with UGIB compared with other scores, correctly identifying patients at low and high death risk while in the hospital through a dynamic re-evaluation of clinical status.
- Published
- 2021
17. The "Hub and Spoke" model has no effect on mortality in acute upper gastrointestinal bleeding: A prospective multicenter cohort study
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Marmo, Riccardo, primary, Soncini, Marco, additional, Bucci, Cristina, additional, Zullo, Angelo, additional, Amitrano, L, additional, Anderloni, A, additional, Andriulli, A, additional, Annese, V, additional, Baldassarre, G, additional, Bargiggia, S, additional, Bazzoli, F, additional, Bennato, R, additional, Bianco, MA, additional, Bizzotto, A, additional, Boarino, V, additional, Bonanomi, AG, additional, Borgheresi, P, additional, Bresci, G, additional, Buffoli, F, additional, Buscarini, E, additional, Castrignanò, G, additional, Cavallaro, LG, additional, Cesaro, P, additional, Chirico, A, additional, Cipolletta, F, additional, Cipolletta, L, additional, Conigliaro, R, additional, Conte, D, additional, Costamagna, G, additional, Covello, F, additional, D'Amico, G, additional, De-Fanis, C, additional, De-Filippo, FR, additional, de-Franchis, R, additional, Dell‘Era, A, additional, De Nigris, F, additional, De-Matthaeis, M, additional, Di-Giorgio, P, additional, Di-Giulio, E, additional, Esposito, P, additional, Ferraris, L, additional, Filippino, A, additional, Franceschi, M, additional, Furio, L, additional, Germana', B, additional, Grassia, R, additional, Imperiali, G, additional, Lamanda, R, additional, Lauri, A, additional, Londoni, C, additional, Mangiafico, S, additional, Manno, M, additional, Marmo, C, additional, Merighi, A, additional, Meroni, R., additional, Metrangolo, S, additional, Montalbano, LM, additional, Napolitano, G, additional, Nucci, A, additional, Orsini, L, additional, Parente, F, additional, Parravicini, M, additional, Paterlini, A, additional, Pumpo, R, additional, Purita, L, additional, Repici, A, additional, Riccioni, ME, additional, Russo, A, additional, Segato, S, additional, Sorrentino, I, additional, Spinzi, G, additional, Spotti, D, additional, Tortora, A, additional, Tomba, C, additional, Triossi, O, additional, Zagari, RM, additional, and Zambelli, A, additional
- Published
- 2021
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18. Cooperation between Myc and YY1 provides novel silencing transcriptional targets of α3β1-integrin in tumour cells
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de Nigris, F, Botti, C, Rossiello, R, Crimi, E, Sica, V, and Napoli, C
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- 2007
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19. Splenic artery transposition for hepatic arterial reconstruction in a locally advanced pancreatic cancer: A case report and literature review
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Tinelli, Giovanni, Montanari, Francesca, Sica, Simona, Razionale, Francesco, Ardito, Francesco, Minelli, Fabrizio, De Nigris, Francesca, Tshomba, Yamume, Giuliante, Felice, Tinelli G. (ORCID:0000-0002-2212-3226), Montanari F., Sica S., Razionale F., Ardito F. (ORCID:0000-0003-1596-2862), Minelli F., de Nigris F., Tshomba Y. (ORCID:0000-0001-7304-7553), Giuliante F. (ORCID:0000-0001-9517-8220), Tinelli, Giovanni, Montanari, Francesca, Sica, Simona, Razionale, Francesco, Ardito, Francesco, Minelli, Fabrizio, De Nigris, Francesca, Tshomba, Yamume, Giuliante, Felice, Tinelli G. (ORCID:0000-0002-2212-3226), Montanari F., Sica S., Razionale F., Ardito F. (ORCID:0000-0003-1596-2862), Minelli F., de Nigris F., Tshomba Y. (ORCID:0000-0001-7304-7553), and Giuliante F. (ORCID:0000-0001-9517-8220)
- Abstract
OBJECTIVE: During pancreatic surgery for malignancies, hepatic revascularization is needed in case of en bloc resection with hepatic artery involvement. In these cases, the use of the splenic artery is described in the literature, including transposition and interposition techniques. PATIENTS AND METHODS: We report the case of pancreatic cancer resection with involvement of the right hepatic artery, anomalous arising from the superior mesenteric artery, and hepatic revascularization with splenic artery reconstruction. A literature review to analyze the use of splenic artery in hepatic revascularization during pancreatic cancer surgery was performed. RESULTS: A 61-year-old man with a 55-mm hypovascular tumor in the pancreatic head, in wide contact with the right hepatic artery, underwent total pancreatectomy and splenectomy. Right hepatic artery was resected, and the distal part of the splenic artery was transposed to the right hepatic artery with a termino-terminal anastomosis. Histopathological examination revealed R0 resection. CONCLUSIONS: Hepatic revascularization with splenic artery should be considered in patients suitable to extend resectability in pancreatic cancer surgery. A multidisciplinary approach and careful pre-operative planning are essential.
- Published
- 2021
20. TEVAR for traumatic thoracic injury with the first-generation stent graft
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Tinelli, Giovanni, Minelli, Fabrizio, Sica, Simona, De Nigris, Francesca, Massetti, Massimo, Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Sica S., De Nigris F., Massetti M. (ORCID:0000-0002-7100-8478), Tshomba Y. (ORCID:0000-0001-7304-7553), Tinelli, Giovanni, Minelli, Fabrizio, Sica, Simona, De Nigris, Francesca, Massetti, Massimo, Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Sica S., De Nigris F., Massetti M. (ORCID:0000-0002-7100-8478), and Tshomba Y. (ORCID:0000-0001-7304-7553)
- Abstract
Thoracic endovascular aortic repair (TEVAR) is a life-saving treatment for blunt thoracic aortic injury. We report long-term outcomes of two young patients who underwent TEVAR for blunt thoracic aortic injury with first-generation thoracic stent grafts. The off-label use of the endograft affected the outcomes: one case of open surgery conversion due to an aortoesophageal fistula and one case of endovascular relining for a voluminous pseudoaneurysm associated with a type III endoleak. Long-term follow-up is crucial in TEVAR, especially in case of a first-generation device used in an urgent setting.
- Published
- 2021
21. Glycoxidation of low–density lipoprotein promotes multiple apoptotic pathways and NFkB activation in human coronary cells
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de Nigris, F., Gallo, L., Sica, V., and Napoli, Claudio
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- 2006
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22. T01.01.7 THE USE OF A SPECIALIZED BLEEDING-MANAGEMENT TEAM HAD NO IMPACT ON MORTALITY FOR ACUTE UPPER GASTROINTESTINAL BLEEDING: AN ITALIAN PROSPECTIVE MULTICENTER COHORT STUDY
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Marmo, R., primary, Soncini, M., additional, Marmo, C., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional
- Published
- 2020
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23. OC.10.1 THE USE OF PRE-ENDOSCOPIC INTRAVENOUS PROTON PUMP INHIBITORS (PPIS) HAD NO IMPACT ON CLINICAL OUTCOMES IN ACUTE UPPER GASTROINTESTINAL BLEEDING: A PROSPECTIVE MULTICENTER ITALIAN COHORT STUDY
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Marmo, R., primary, Soncini, M., additional, Bucci, C., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Spotti, D., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional
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- 2020
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24. Long-term results of hybrid repair techniques for Kommerell's diverticulum
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Tinelli, Giovanni, primary, Ferrer, Ciro, additional, Giudice, Rocco, additional, Ferraresi, Marco, additional, Pogany, Gabriele, additional, Cao, Piergiorgio, additional, Tshomba, Yamume, additional, Montenegro, C., additional, De Nigris, F., additional, Minelli, F., additional, Sica, S., additional, and Coscarella, C., additional
- Published
- 2020
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25. Epigenetic Hallmarks of Fetal Early Atherosclerotic Lesions in Humans
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de Nigris F, Cacciatore F, Mancini FP, Vitale DF, Mansueto G, D'Armiento FP, Schiano C, Soricelli A, Napoli C, SCHIANO, Concetta, de Nigris, F, Cacciatore, F, Mancini, Fp, Vitale, Df, Mansueto, G, D'Armiento, Fp, Schiano, C, Soricelli, A, Napoli, C., Napoli, C, and Schiano, Concetta
- Subjects
0301 basic medicine ,Male ,medicine.medical_specialty ,Offspring ,Aorta, Thoracic ,030204 cardiovascular system & hematology ,Polymerase Chain Reaction ,Epigenesis, Genetic ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,Pregnancy ,Internal medicine ,medicine ,Humans ,Immunoprecipitation ,Liver X receptor ,Cells, Cultured ,Original Investigation ,Fetus ,biology ,business.industry ,Cholesterol ,Cholesterol, HDL ,DNA Methylation ,medicine.disease ,Atherosclerosis ,Immunohistochemistry ,030104 developmental biology ,Endocrinology ,chemistry ,Receptors, LDL ,ABCA1 ,LDL receptor ,biology.protein ,RNA ,Female ,Endothelium, Vascular ,business ,Cardiology and Cardiovascular Medicine ,Lipoprotein ,Sterol Regulatory Element Binding Protein 2 - Abstract
Importance Although increasingly strong evidence suggests a role of maternal total cholesterol and low-density lipoprotein cholesterol (LDLC) levels during pregnancy as a risk factor for atherosclerotic disease in the offspring, the underlying mechanisms need to be clarified for future clinical applications. Objective To test whether epigenetic signatures characterize early fetal atherogenesis associated with maternal hypercholesterolemia and to provide a quantitative estimate of the contribution of maternal cholesterol level to fetal lesion size. Design, Setting, and Participants This autopsy study analyzed 78 human fetal aorta autopsy samples from the Division of Human Pathology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy. Maternal levels of total cholesterol, LDLC, high-density lipoprotein cholesterol (HDLC), triglycerides, and glucose and body mass index (BMI) were determined during hospitalization owing to spontaneous fetal death. Data were collected and immediately processed and analyzed to prevent degradation from January 1, 2011, through November 30, 2016. Main Outcomes and Measurements Results of DNA methylation and messenger RNA levels of the following genes involved in cholesterol metabolism were assessed: superoxide dismutase 2 ( SOD2 ), low-density lipoprotein receptor ( LDLR ), sterol regulatory element binding protein 2 (SREBP2) , liver X receptor α ( LXRα ), and adenosine triphosphate–binding cassette transporter 1 ( ABCA1 ). Results Among the 78 fetal samples included in the analysis (59% male; mean [SD] fetal age, 25 [3] weeks), maternal cholesterol level explained a significant proportion of the fetal aortic lesion variance in multivariate analysis (61%; P = .001) independently by the effect of levels of HDLC, triglycerides, and glucose and BMI. Moreover, maternal total cholesterol and LDLC levels were positively associated with methylation of SREBP2 in fetal aortas (Pearson correlation, 0.488 and 0.503, respectively), whereas in univariate analysis, they were inversely correlated with SREBP2 messenger RNA levels in fetal aortas (Pearson correlation, −0.534 and −0.671, respectively). Epivariations of genes controlling cholesterol metabolism in cholesterol-treated human aortic endothelial cells were also observed. Conclusions and Relevance The present study provides a stringent quantitative estimate of the magnitude of the association of maternal cholesterol levels during pregnancy with fetal aortic lesions and reveals the epigenetic response of fetal aortic SREBP2 to maternal cholesterol level. The role of maternal cholesterol level during pregnancy and epigenetic signature in offspring in cardiovascular primary prevention warrants further long-term causal relationship studies.
- Published
- 2018
26. Management of mycotic aorto-iliac aneurysms: a 30-year monocentric experience
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Tshomba, Yamume, Sica, S., Minelli, Fabrizio, Giovannini, Silvia, Murri, Rita, De Nigris, F., Codispoti, Francesco Alberto, Sticchi, D., and Tinelli, Giovanni
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mycotic ,aneurysm ,Settore MED/17 - MALATTIE INFETTIVE ,Settore MED/22 - CHIRURGIA VASCOLARE - Published
- 2020
27. Effect of gestational hypercholesterolaemia on omental vasoreactivity, placental enzyme activity and transplacental passage of normal and oxidised fatty acids
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Liguori, A, DʼArmiento, F P, Palagiano, A, Balestrieri, M L, Williams-Ignarro, S, de Nigris, F, Lerman, L O, DʼAmora, M, Rienzo, M, Fiorito, C, Ignarro, L J, Palinski, W, and Napoli, C
- Published
- 2007
28. Long-term results of hybrid repair techniques for Kommerell's diverticulum
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Tinelli, Giovanni, Ferrer, C., Giudice, R., Ferraresi, M., Pogany, G., Cao, P., Tshomba, Yamume, Montenegro, C., De Nigris, F., Minelli, Fabrizio, Sica, S., Coscarella, C., Tinelli G. (ORCID:0000-0002-2212-3226), Tshomba Y. (ORCID:0000-0001-7304-7553), Minelli F., Tinelli, Giovanni, Ferrer, C., Giudice, R., Ferraresi, M., Pogany, G., Cao, P., Tshomba, Yamume, Montenegro, C., De Nigris, F., Minelli, Fabrizio, Sica, S., Coscarella, C., Tinelli G. (ORCID:0000-0002-2212-3226), Tshomba Y. (ORCID:0000-0001-7304-7553), and Minelli F.
- Abstract
Objective: The aim of this study was to evaluate early and late results of hybrid repair techniques for Kommerell's diverticulum (KD). Methods: All patients who underwent hybrid repair (thoracic endovascular aortic repair + supra-aortic debranching) for KD between 2009 and 2018 were included in this retrospective multicenter study (three Italian centers). A proximal landing zone (PLZ) of at least 2 cm of healthy aorta was considered adequate for the deployment of a standard thoracic stent graft. The early end points were technical success, in-hospital mortality, and cerebrovascular events. Late outcomes included survival, reintervention, and patency of supra-aortic debranching. We used an embryogenetic anomaly based aortic arch classification for PLZ evaluation to identify the most appropriate hybrid adjunct. Results: Sixteen patients with KD were included. According to the aforementioned classification, stent graft deployment was required in six patients (37.5%) in PLZ 0, nine patients (56.3%) in PLZ 1, and one patient (6.3%) in PLZ 2. Technical success was achieved in all patients. One patient (6.3%) died in the hospital because of posterior cerebral hemorrhage after total debranching (PLZ 0). No further cerebrovascular events were observed. One patient (6.3%) had an asymptomatic left subclavian artery-right left subclavian artery bypass occlusion and required early reintervention. The 30-day secondary patency of supra-aortic debranching was 100%. Two type II endoleaks (12.5%) were detected at 1 month through computed tomography angiography. Further transient complications were found in three cases: hemidiaphragm paralysis in one patient and recurrent laryngeal nerve paralysis in two patients. At a mean follow-up of 48 months, four patients had died because of nonaortic reasons, and one RCCA-right subclavian artery bypass had lost its patency. None of the patients reported any growth of KD after hybrid repair. Ten patients (62.5%) showed aneurysmal sac shrinkage o
- Published
- 2020
29. Thoracoabdominal aortic aneurysm open repair with bilateral multiple renal arteries
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Tinelli, Giovanni, Scurto, L., Sica, S., Minelli, Fabrizio, De Nigris, F., Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Tshomba Y. (ORCID:0000-0001-7304-7553), Tinelli, Giovanni, Scurto, L., Sica, S., Minelli, Fabrizio, De Nigris, F., Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., and Tshomba Y. (ORCID:0000-0001-7304-7553)
- Abstract
Multiple renal arteries are a common renal vascular variant. A study with 800 kidneys from cadaver donors demonstrated 1% prevalence of quadruple renal arteries. During thoracoabdominal aortic aneurysm (TAAA) repair, this anomaly implies longer time of renal ischemia and well-defined reperfusion strategy.2 Acute kidney injury during TAAA repair is a common complication with 6% to 7% incidence. It can be prevented by histidine-tryptophan-ketoglutarate solution (Custodiol; Dr Franz-Köhler Chemie GmbH, Bensheim, Germany) renal perfusion. We report successful organ preservation during TAAA open repair in a 61-year-old man with multiple renal arteries.
- Published
- 2020
30. Long-term follow-up of adventitial cyst surgical excision in external iliac vein
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Tinelli, Giovanni, Montanari, Francesca, Minelli, Fabrizio, De Nigris, F., Sica, S., Tshomba, Yamume, Tinelli, G. (ORCID:0000-0002-2212-3226), Montanari, F., Minelli, F., Tshomba, Y. (ORCID:0000-0001-7304-7553), Tinelli, Giovanni, Montanari, Francesca, Minelli, Fabrizio, De Nigris, F., Sica, S., Tshomba, Yamume, Tinelli, G. (ORCID:0000-0002-2212-3226), Montanari, F., Minelli, F., and Tshomba, Y. (ORCID:0000-0001-7304-7553)
- Abstract
Adventitial cystic disease (ACD) of the venous system is an extremely rare condition. Forty-five cases are described in the literature over the last 70 years, but they may not be truthful about the real incidence of this pathology. We report a case of an ACD compressing the right external iliac vein and presenting with edema of the ipsilateral leg. Ultrasound imaging and computed tomography angiography showed the typical features of the cystic disease and venous stenosis. Cyst excision was performed with a double surgical access. No peri-operative complications were reported. There was no recurrence at 4-year follow-up.
- Published
- 2020
31. Horseshoe Kidney Protection with Histidine-Tryptophan-Ketoglutarate Solution during Surgical Abdominal Aortic Aneurysm Repair
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Tinelli, Giovanni, Sica, S., Minelli, Fabrizio, Natola, Marco, De Nigris, F., Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Natola M., Tshomba Y. (ORCID:0000-0001-7304-7553), Tinelli, Giovanni, Sica, S., Minelli, Fabrizio, Natola, Marco, De Nigris, F., Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Natola M., and Tshomba Y. (ORCID:0000-0001-7304-7553)
- Abstract
Case Report: We report an unusual case of a 65-year-old male patient with horseshoe kidney, who underwent a successful open repair for an abdominal aortic aneurysm (AAA). The accessory renal arteries were perfused with histidine-tryptophan-ketoglutarate (HTK) solution (Custodiol®; Dr. Franz-Kohler Chemie GmbH, Bensheim, Germany) during the vascular reconstruction. There were no creatinine and estimated glomerular filtration rate (eGFR) modifications in the postoperative time. In the literature, only two cases of Custodiol solution for kidney protection during aortic surgery are reported. To the best of our knowledge, this is the first case of Custodiol perfusion for horseshoe kidney protection. Discussion: The concomitant presence of horseshoe kidney and an AAA requires a specific preoperative planning. This is necessary to define the appropriate surgical procedure and strategy. The onset of acute kidney injury is an aspect that must always be taken into consideration during aortic surgery, even more in the case we are reporting. Indeed, despite the complexity of the kidney anatomy, the use of Custodiol solution allowed a proper maintenance of the perioperative renal function, as shown by the postoperative levels of creatinine and eGFR. Conclusions: Preoperative planning and organ preservation are crucial in AAA open repair, especially in the presence of congenital anomalies such as horseshoe kidney.
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- 2020
32. Sulfhydryl angiotensin-converting enzyme inhibition induces sustained reduction of systemic oxidative stress and improves the nitric oxide pathway in patients with essential hypertension
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Napoli, C., Sica, V., de Nigris, F., Pignalosa, O., Condorelli, M., Ignarro, L. J., and Liguori, A.
- Published
- 2004
33. Evidence that protease activated receptor 2 expression is enhanced in human coronary atherosclerotic lesions
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Napoli, C, de Nigris, F, Wallace, J L, Hollenberg, M D, Tajana, G, De Rosa, G, Sica, V, and Cirino, G
- Published
- 2004
34. Review article: maintenance treatment of Crohnʼs disease
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BIANCONE, L., TOSTI, C., FINA, D., FANTINI, M., DE NIGRIS, F., GEREMIA, A., and PALLONE, F.
- Published
- 2003
35. Microarray analysis: a novel research tool for cardiovascular scientists and physicians
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Napoli, C, Lerman, L O, Sica, V, Lerman, A, Tajana, G, and de Nigris, F
- Published
- 2003
36. New challenges in integrated diagnosis by imaging and osteo-immunology in bone lesions
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Schiano C, Soricelli A, de Nigris F, Napoli C, SCHIANO, Concetta, Schiano, C, Soricelli, A, de Nigris, F, Napoli, C, and Schiano, Concetta
- Subjects
0301 basic medicine ,Diagnostic Imaging ,Pathology ,medicine.medical_specialty ,Tumour heterogeneity ,Osteoimmunology ,Immunology ,Bone Neoplasms ,CXCR4 ,Multimodal Imaging ,Imaging ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Immunology and Allergy ,Humans ,Bone ,030203 arthritis & rheumatology ,biology ,business.industry ,Marker ,Tumour ,Gold standard (test) ,Precision medicine ,030104 developmental biology ,Primary bone ,Bone lesion ,RANKL ,biology.protein ,business ,Biomarkers - Abstract
High-resolution imaging is the gold standard to measure the functional and biological features of bone lesions. Imaging markers have allowed the characterization both of tumour heterogeneity and metabolic data. Besides, ongoing studies are evaluating a combined use of 'imaging markers', such as SUVs, MATV, TLG, ADC from PET and MRI techniques respectively, and several 'biomarkers' spanning from chemokine immune-modulators, such as PD-1, RANK/RANKL, CXCR4/CXCL12 to transcription factors, such as TP53, RB1, MDM2, RUNX family, EZH2, YY1, MAD2. Osteoimmunology may improve diagnosis and prognosis leading to precision medicine in bone lesion treatment. Areas covered: We investigated modalities (molecular and imaging approach) useful to identify bone lesions deriving both from primary bone tumours and from osteotropic tumours, which have a higher incidence, prevalence and prognosis. Here, we summarized the recent advances in imaging techniques and osteoimmunology biomarkers which could play a pivotal role in personalized treatment. Expert commentary: Although imaging and molecular integration could allow both early diagnosis and stratification of cancer prognosis, large scale clinical trials will be necessary to translate pilot studies in the current clinical setting.ADC: apparent diffusion coefficient; ALCAM: Activated Leukocyte Cell Adhesion Molecule; ALP: Alkaline phosphatases; BC: Breast cancer; BSAP: B-Cell Lineage Specific Activator; BSAP: bone-specific alkaline phosphatase; BSP: bone sialoprotein; CRIP1: cysteine-rich intestinal protein 1; CD44: cluster of differentiation 44; CT: computed tomography; CXCL12: C-X-C motif ligand 12; CXCR4: C-X-C C-X-C chemokine receptor type 4; CTLA-4: Cytotoxic T-lymphocyte antigen 4; CTX-1: C-terminal end of the telopeptide of type I collagen; DC: dendritic cell; DWI: Diffusion-weighted MR image; EMT: mesenchymal transition; ET-1: endothelin-1; FDA: Food and Drug Administration; FDG
- Published
- 2018
37. Monitoring the activity of Crohn's disease
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Biancone, L, De Nigris, F, Del Vecchio Blanco, G, Monteleone, I, Vavassori, P, Geremia, A, and Pallone, F
- Published
- 2002
38. Correction: CXCR4/YY1 inhibition impairs VEGF network and angiogenesis during malignancy (Proceedings of the National Academy of Sciences of the United States of America (2010) 107 (14484–14489) DOI: 10.1073/pnas.1008256107)
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De Nigris, F., Crudele, V., Giovane, A., Casamassimi, A., Giordano, A., Garban, H. J., Cacciatore, F., Pentimalli, F., Marquez-Garban, D. C., Petrillo, A., Cito, L., Sommese, L., Fiore, A., Petrillo, M., Siani, A., Barbieri, A., Arra, C., Rengo, F., Hayashi, T., Al-Omran, M., Ignarro, L. J., and Napoli, C.
- Published
- 2019
39. OC.11.5 TRIGGER AND TARGET TRANSFUSION STRATEGY IN PATIENTS WITH NON-VARICEAL ACUTE UPPER GASTROINTESTINAL BLEEDING (NV-AUGIB): A PROSPECTIVE MULTICENTRE OBSERVATIONAL STUDY
- Author
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Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Spada, C., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional
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- 2019
- Full Text
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40. Splenic artery transposition for hepatic arterial reconstruction in a locally advanced pancreatic cancer: a case report and literature review.
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TINELLI, G., MONTANARI, F., SICA, S., RAZIONALE, F., ARDITO, F., MINELLI, F., DE NIGRIS, F., TSHOMBA, Y., and GIULIANTE, F.
- Abstract
OBJECTIVE: During pancreatic surgery for malignancies, hepatic revascularization is needed in case of en bloc resection with hepatic artery involvement. In these cases, the use of the splenic artery is described in the literature, including transposition and interposition techniques. PATIENTS AND METHODS: We report the case of pancreatic cancer resection with involvement of the right hepatic artery, anomalous arising from the superior mesenteric artery, and hepatic revascularization with splenic artery reconstruction. A literature review to analyze the use of splenic artery in hepatic revascularization during pancreatic cancer surgery was performed. RESULTS: A 61-year-old man with a 55-mm hypovascular tumor in the pancreatic head, in wide contact with the right hepatic artery, underwent total pancreatectomy and splenectomy. Right hepatic artery was resected, and the distal part of the splenic artery was transposed to the right hepatic artery with a termino-terminal anastomosis. Histopathological examination revealed R0 resection. CONCLUSIONS: Hepatic revascularization with splenic artery should be considered in patients suitable to extend resectability in pancreatic cancer surgery. A multidisciplinary approach and careful pre-operative planning are essential. [ABSTRACT FROM AUTHOR]
- Published
- 2021
41. Endoanchors under 3D image fusion for a type IA endoleak after EVAR
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Tinelli, Giovanni, De Nigris, F., Minelli, Fabrizio, Flore, Roberto Antonio, Santoliquido, Angelo, Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Flore R. (ORCID:0000-0003-1659-1338), Santoliquido A. (ORCID:0000-0003-1539-4017), Tshomba Y. (ORCID:0000-0001-7304-7553), Tinelli, Giovanni, De Nigris, F., Minelli, Fabrizio, Flore, Roberto Antonio, Santoliquido, Angelo, Tshomba, Yamume, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Flore R. (ORCID:0000-0003-1659-1338), Santoliquido A. (ORCID:0000-0003-1539-4017), and Tshomba Y. (ORCID:0000-0001-7304-7553)
- Abstract
The Heli-FX technique for type IA EL under 3D-IF proved to be accurate in terms of EL channel vision and correct endoanchors deployment. The EL volume rendering constant view allowed a precise anchors fixation at the EL channel. 3D-IF confirmed to be a valid help in orientation and navigation during endovascular aortic procedure.
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- 2019
42. c-Myc Activation in Early Coronary Lesions in Experimental Hypercholesterolemia
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de Nigris, F., Lerman, L.O., Rodriguez-Porcel, M., De Montis, M.P., Lerman, A., and Napoli, C.
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- 2001
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43. Chronic treatment with sulfhydryl angiotensin-converting enzyme inhibitors reduce susceptibility of plasma LDL to in vitro oxidation, formation of oxidation-specific epitopes in the arterial wall, and atherogenesis in apolipoprotein E knockout mice
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de Nigris, F, D’Armiento, F.P, Somma, P, Casini, A, Andreini, I, Sarlo, F, Mansueto, G, De Rosa, G, Bonaduce, D, Condorelli, M, and Napoli, C
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- 2001
- Full Text
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44. Management of mycotic aorto-iliac aneurysms: a 30-year monocentric experience.
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TSHOMBA, Y., SICA, S., MINELLI, F., GIOVANNINI, S., MURRI, R., DE NIGRIS, F., CODISPOTI, F. A., STICCHI, D., and TINELLI, G.
- Abstract
OBJECTIVE: This study aims to analyze the early and late outcomes of our 30-year experience with mycotic aneurysms of the abdominal aorta and iliac arteries. PATIENTS AND METHODS: This retrospective cohort study compared the outcomes of all the patients with mycotic aneurysm, by analyzing prospectively collected data between September 1989 and October 2019 from the Unit of Vascular Surgery of Fondazione Policlinico Universitario Gemelli - IRCCS in Rome, Italy. RESULTS: Twenty-three patients with mycotic aneurysm were included. Twenty-two patients underwent surgery; one patient arrived at the emergency room with unstable clinical conditions and died before being treated. Fourteen cases (60.9%) were located at the infrarenal aorta, while three cases (13.0%) were pararenal aortic aneurysms. Six cases (26.1%) had an iliac arteries localization. Seventeen patients (77.3%) underwent open surgical repair aneurysmectomy with in situ reconstruction, while three cases (13.6%) underwent extra-anatomic revascularization. Three patients (13.6%) underwent the placement of an endoprosthesis, of whom two underwent hybrid procedures, and one EVAR. The latter underwent an early conversion to open repair due to a type I endoleak. The mean length of hospital stay was 35 ± 18.7 days. Five patients (22.7%) died in the immediate postoperative period. In the follow-up of 45.5 ± 41.3 months (range 2-156), we documented six deaths (35.3%), of whom two (11.8%) were aortic-related for a 34.8% overall aortic-related mortality. Eleven patients were alive, with an overall survival of 47.8%. CONCLUSIONS: Mycotic aneurysm is an extremely rare and varied pathology. Open surgical repair showed to be a safe approach because of a complete and aggressive debridement of local infected tissues, with an acceptable long-term mortality rate. [ABSTRACT FROM AUTHOR]
- Published
- 2020
45. OC.14.2 PREDICTIVE FACTORS OF MORTALITY IN ACUTE GASTROINTESTINAL BLEEDING IN ITALY (AUGIB): A NEW PRE-ENDOSCOPY PROGNOSTIC MODEL FROM A MULTICENTER STUDY
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Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, De Franchis, R., additional, Dell'Eera, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, Conte, D., additional, Spinzi, G., additional, Di Giulio, E., additional, D'Amico, G., additional, and Balzano, A., additional
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- 2018
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46. Quantitative digital subtraction angiography to localize intercostal arteries during thoracic endovascular aortic repair
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Tinelli, Giovanni, Minelli, Fabrizio, De Nigris, F., Flex, Andrea, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Flex A. (ORCID:0000-0003-2664-4165), Tinelli, Giovanni, Minelli, Fabrizio, De Nigris, F., Flex, Andrea, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., and Flex A. (ORCID:0000-0003-2664-4165)
- Abstract
The accurate identification and preservation of critical intercostal arteries are important technical issues during thoracic endovascular aortic repair (TEVAR) to reduce the risk of postoperative paraparesis. The localization of intercostal arteries by digital subtraction angiography (DSA) before deployment of a stent graft is often difficult because of their small caliber and posterior orientation. Parametric color coding is an imaging software that measures flow dynamics in a DSA series and provides quantitative information without the additional cost of an X ray dose and contrast medium. In a single image, quantitative DSA (Q-DSA; syngo iFlow software; Siemens, Forchheim, Germany) provides information on the transit of contrast medium through vessels We describe the use of Q-DSA to localize and preserve the intercostal arteries in the distal descending aorta during TEVAR.
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- 2018
47. Quantitative digital subtraction angiography during type B chronic aortic dissection endovascular repair
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Tinelli, Giovanni, De Nigris, F., Minelli, Fabrizio, Vincenzoni, Claudio, Flex, Andrea, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Vincenzoni C., Flex A. (ORCID:0000-0003-2664-4165), Tinelli, Giovanni, De Nigris, F., Minelli, Fabrizio, Vincenzoni, Claudio, Flex, Andrea, Tinelli G. (ORCID:0000-0002-2212-3226), Minelli F., Vincenzoni C., and Flex A. (ORCID:0000-0003-2664-4165)
- Abstract
Angiographic assessment of type B chronic aortic dissection can be complicated in thoracic endovascular aortic repair (TEVAR) procedures due to a complex flow pattern. The challenge in identifying the true and false lumen and the precise deployment of the endograft in the true lumen are hotspots in endovascular treatment dissections. Parametric color coding (PCC) is a recent tool for measuring flow dynamics in a digital subtraction angiography (DSA) series that provides quantitative information. In a single image, the quantitative DSA (Q-DSA; Syngo iFlow software; Siemens, Forchheim, Germany) displays objective information on the contrast medium through vessels. We describe the potential utility of Q-DSA in the endovascular treatment of a 76-year-old man who presented with a thoracic false lumen aneurysm measuring 6.2 cm accompanied by a large proximal entry tear.
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- 2018
48. The potential role of quantitative digital subtraction angiography in evaluating type B chronic aortic dissection during TEVAR: preliminary results
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Tinelli, Giovanni, Minelli, Fabrizio, De Nigris, Francesca, Vincenzoni, Claudio, Filipponi, Marco, Bruno, Piergiorgio, Massetti, Massimo, Flex, Andrea, Iezzi, Roberto, Tinelli, G (ORCID:0000-0002-2212-3226), Minelli, F, De Nigris, F, Vincenzoni, C, Bruno, P (ORCID:0000-0002-1075-5808), Massetti, M (ORCID:0000-0002-7100-8478), Flex, A (ORCID:0000-0003-2664-4165), Iezzi, R (ORCID:0000-0002-2791-481X), Tinelli, Giovanni, Minelli, Fabrizio, De Nigris, Francesca, Vincenzoni, Claudio, Filipponi, Marco, Bruno, Piergiorgio, Massetti, Massimo, Flex, Andrea, Iezzi, Roberto, Tinelli, G (ORCID:0000-0002-2212-3226), Minelli, F, De Nigris, F, Vincenzoni, C, Bruno, P (ORCID:0000-0002-1075-5808), Massetti, M (ORCID:0000-0002-7100-8478), Flex, A (ORCID:0000-0003-2664-4165), and Iezzi, R (ORCID:0000-0002-2791-481X)
- Abstract
OBJECTIVE: To evaluate the role of quantitative digital subtraction angiography (Q-DSA) with parametric color coding (PCC) in assessing patients with type B chronic thoracic aortic dissection (TBCAD) during thoracic endovascular aortic repair (TEVAR) procedures. PATIENTS AND METHODS: A total of 11 patients electively treated in our Department for a TBCAD were retrospectively enrolled. All cases were treated with TEVAR for false lumen aneurysm of the thoracic descending aorta. For digital subtraction angiography (DSA) series post-processing, a newly implemented PCC algorithm was used to turn consecutive two-dimensional images into a single color-coded picture (syngo iFLOW, Siemens AG, Forchheim, Germany). In consensus reading, two clinicians experienced in vascular imaging evaluated the DSA series in blinded assessment and compared them to the color-coded images. PCC was assessed for its accuracy in identifying the true and false lumen as well as whether it could provide improved visualization in pre-deployment stent grafting and the final evaluation of treatment. RESULTS: PCC facilitated the visualization of the aortic dissection angioarchitecture in terms of contemporary true and false lumen vision in 81.8% of the cases. In 72.7% of the procedures, Q-DSA was estimated to improve aorta information assessment in terms of false lumen viewing, and it was possible to identify the proximal entry tear position in 45.4% of the cases. After stent graft deployment, in 72.7% of the cases (all 8 patients in which the aortic arch false lumen was visible in pre-treatment), Q-DSA confirmed the absence of early false lumen reperfusion. CONCLUSIONS: Our results indicate that Q-DSA could be useful in the intraprocedural evaluation of patients with aortic dissection during TEVAR procedures without additional x-ray costs and contrast exposure.
- Published
- 2018
49. P.10.8: Mortality from Acute Upper Gastrointestinal Bleeding (UGIB): The Role of the Organizational and Health Care Course: A Prospective Multicentre Observational Study in Italy
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Marmo, R., primary, Soncini, M., additional, Cipolletta, F., additional, Orsini, L., additional, Bennato, R., additional, Guardascione, M., additional, Parente, F., additional, Bargiggia, S., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Metrangolo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Rotondano, G., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, A., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional
- Published
- 2017
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50. P.10.1: Transfusion Strategy and Death Risk in Patients with Acute Non-Variceal Upper Gastro Intestinal Bleeding (NV-UGIB) in Italy: A Prospective Multicenter Observational Study
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Marmo, R., primary, Soncini, M., additional, Bennato, R., additional, Cipolletta, F., additional, Orsini, L., additional, Amitrano, L., additional, Parente, F., additional, Bargiggia, S., additional, Paterlini, A., additional, Cesaro, P., additional, Bizzotto, A., additional, Germanà, B., additional, Cavallaro, L.G., additional, Dell’Era, A., additional, Costamagna, G., additional, Riccioni, M.E., additional, Marmo, C., additional, Tortora, A., additional, Manno, M., additional, Mangiafico, S., additional, Conigliaro, R., additional, Bresci, G., additional, Mastrangelo, S., additional, Merighi, A., additional, Boarino, V., additional, Segato, S., additional, Parravicini, M., additional, Purita, L., additional, Chirico, A., additional, Imperiali, G., additional, Gasparini, P., additional, Bucci, C., additional, Esposito, F., additional, Borgheresi, P., additional, De Filippo, F.R., additional, Baldassarre, G., additional, Franceschi, M., additional, Nucci, A., additional, De Nigris, F., additional, Ferraris, L., additional, Zambelli, A., additional, Londoni, C., additional, Repici, A., additional, Anderloni, A., additional, De Matthaeis, M., additional, Triossi, O., additional, Bianco, M.A., additional, Zingone, F., additional, Lamanda, R., additional, Lauri, R., additional, De Fanis, C., additional, Di Giorgio, P., additional, Pumpo, R., additional, Furio, L., additional, Russo, A., additional, Andriulli, A., additional, Napolitano, G., additional, Montalbano, L.M., additional, Bazzoli, F., additional, Zagari, R.M., additional, Buscarini, E., additional, Cipolletta, L., additional, De Franchis, R., additional, Spinzi, G., additional, Di Giulio, E., additional, D’Amico, G., additional, Balzano, A., additional, and Conte, D., additional
- Published
- 2017
- Full Text
- View/download PDF
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