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17 results on '"De Paolo, Raffaella"'

4. Enhancing the Anticancer Activity of Attenuated Listeria monocytogenes by Cell Wall Functionalization with "Clickable" Doxorubicin.

Author

Lepori, Irene, Roncetti, Marta, Vitiello, Marianna, Barresi, Elisabetta, De Paolo, Raffaella, Tentori, Paolo Maria, Baldanzi, Caterina, Santi, Melissa, Evangelista, Monica, Signore, Giovanni, Tedeschi, Lorena, Gravekamp, Claudia, Cardarelli, Francesco, Taliani, Sabrina, Da Settimo, Federico, Siegrist, M. Sloan, and Poliseno, Laura

Published
2024
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10. Additional file 1 of PARP1 negatively regulates MAPK signaling by impairing BRAF-X1 translation

Author

Marranci, Andrea, Prantera, Antonella, Masotti, Simona, De Paolo, Raffaella, Baldanzi, Caterina, Podda, Maurizio S., Mero, Serena, Vitiello, Marianna, Franchin, Cinzia, Laezza, Mariavittoria, Comelli, Laura, Arrigoni, Giorgio, Cervelli, Tiziana, Del Pozzo, Giovanna, and Poliseno, Laura

Abstract

Additional file 1. Supplementary Material: REMSA analysis.

Published
2023
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15. Characterization of paralogous uncx transcription factor encoding genes in zebrafish

Author

Nittoli, Valeria, primary, Fortunato, Antonio Emidio, additional, Fasano, Giulia, additional, Coppola, Ugo, additional, Gentile, Alessandra, additional, Maiella, Sylvie, additional, Langellotto, Fernanda, additional, Porreca, Immacolata, additional, De Paolo, Raffaella, additional, Marino, Rita, additional, Fiengo, Marcella, additional, Donizetti, Aldo, additional, Aniello, Francesco, additional, Kondo, Takashi, additional, Ristoratore, Filomena, additional, Canzoniero, Lorella M.T., additional, Duboule, Denis, additional, Wilson, Stephen W., additional, and Sordino, Paolo, additional

Published
2019
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16. Enhancing the Anticancer Activity of Attenuated Listeria monocytogenesby Cell Wall Functionalization with “Clickable” Doxorubicin

Author

Lepori, Irene, Roncetti, Marta, Vitiello, Marianna, Barresi, Elisabetta, De Paolo, Raffaella, Tentori, Paolo Maria, Baldanzi, Caterina, Santi, Melissa, Evangelista, Monica, Signore, Giovanni, Tedeschi, Lorena, Gravekamp, Claudia, Cardarelli, Francesco, Taliani, Sabrina, Da Settimo, Federico, Siegrist, M. Sloan, and Poliseno, Laura

Abstract

Among bacteria used as anticancer vaccines, attenuated Listeria monocytogenes(Lmat) stands out, because it spreads from one infected cancer cell to the next, induces a strong adaptive immune response, and is suitable for repeated injection cycles. Here, we use click chemistry to functionalize the Lmatcell wall and turn the bacterium into an “intelligent carrier” of the chemotherapeutic drug doxorubicin. Doxorubicin-loaded Lmatretains most of its biological properties and, compared to the control fluorophore-functionalized bacteria, shows enhanced cytotoxicity against melanoma cells both in vitro and in a xenograft model in zebrafish. Our results show that drugs can be covalently loaded on the Lmatcell wall and pave the way to the development of new two-in-one therapeutic approaches combining immunotherapy with chemotherapy.

Published
2024
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