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9 results on '"De Pascale, Francesca"'

3. Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone

Author

Rendina, Domenico, primary, De Filippo, Gianpaolo, additional, Postiglione, Loredana, additional, Covelli, Bianca, additional, Ricciardone, Margherita, additional, Guillaume, Séverine, additional, Di Spigna, Gaetano, additional, Selleri, Carmine, additional, Merlotti, Daniela, additional, Bianciardi, Simone, additional, Materozzi, Maria, additional, Muscariello, Riccardo, additional, De Pascale, Francesca, additional, D'Elia, Lanfranco, additional, Nuti, Ranuccio, additional, Strazzullo, Pasquale, additional, and Gennari, Luigi, additional

Published
2018
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4. The Hyposodic Diet Reduces Urinary Supersaturation Index of Calcium-Oxalate Salts in Calcium-Oxalate Stone Formers with Metabolic Syndrome

Author

De Pascale, Francesca, di Cola, Michele Schiano, Muscariello, Riccardo, De Filippo, Gianpaolo, Strazzullo, Pasquale, Rendina, Domenico, De Pascale, Francesca, di Cola, Michele Schiano, Muscariello, Riccardo, De Filippo, Gianpaolo, Strazzullo, Pasquale, and Rendina, Domenico

Abstract

Background: Nutritional factors play a key role in the pathogenesis of both metabolic syndrome (MS) and calcium-oxalate (CaOx) nephrolithiasis (NL), two clinical entities strictly related. A reduction in dietary salt intake was universally recommended for treatment and prevention of MS and CaOx-NL. The aim of this study was to assess the efficacy of an hyposodic and normocalcic 7-days diet on the urinary supersaturation index of CaOx salts (APCaOx), which is the driving force for CaOx crystallization and aggregation. Patients and Methods: 18 patients with CaOx-NL and MS were evaluated on free diet and after 7 days of hyposodic and normocalcic metabolic diet. The adherence to prescribed metabolic diet was evaluated measuring the 24 h urinary sodium excretion before and after the diet: all enrolled patients showed an urinary sodium excretion, non disponibile

Published
2017

7. La dieta iposodica riduce l'indice di sovrasaturazione urinaria dei sali di ossalato di calcio (AP-CaOx) nei pazienti con nefrolitiasi ossalato-calcica e sindrome metabolica.

Author

De Pascale, Francesca, di Cola, Michele Schiano, Muscariello, Riccardo, De Filippo, Gianpaolo, Strazzullo, Pasquale, and Rendina, Domenico

Abstract

The hyposodic diet reduces urinary supersaturation index of calcium-oxalate salts in calcium-oxalate stone formers with metabolic syndrome Background: Nutritional factors play a key role in the pathogenesis of both metabolic syndrome (MS) and calcium-oxalate (CaOx) nephrolithiasis (NL), two clinical entities strictly related. A reduction in dietary salt intake was universally recommended for treatment and prevention of MS and CaOx-NL. The aim of this study was to assess the efficacy of an hyposodic and normocalcic 7-days diet on the urinary supersaturation index of CaOx salts (APcaox), which is the driving force for CaOx crystallization and aggregation. Patients and Methods: 18 patients with CaOx-NL and MS were evaluated on free diet and after 7 days of hyposodic and normocalcic metabolic diet. The adherence to prescribed metabolic diet was evaluated measuring the 24 h urinary sodium excretion before and after the diet: all enrolled patients showed an urinary sodium excretion ≤100 mmol/24 h after the diet. Results: In addition to the decrease in urinary sodium excretion (185.2 ± 9.9 vs 89.2 ± 9.6 mmol/24 h; p<0.01), we observed also a reduction in the 24 h urinary calcium (6.49 ± 0.09 vs 5.31 ± 0.25 mmol/24 h; p<0.01) and oxalate excretions (0.44 ± 0.06 vs 0.30 ± 0.04 mmol/24 h; p<0.01) and in the 24 h urinary volume (1.85 ± 0.09 vs 1.61 ± 0.09 mmol/24 h; p<0.01). APcaox declined significantly after the diet (1.48 ± 0.09 vs 1.12 ± 0.05; p<0.01). Discussion: The reduction in dietary salt intake significantly reduces the APcaox index and could play an important role in the prevention of CaOx-NL associated to MS. [ABSTRACT FROM AUTHOR]

Published
2017
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8. Interleukin-6 trans-signaling and pathological low back pain in patients with Paget disease of bone

Author

Bianca Covelli, Pasquale Strazzullo, Gaetano Di Spigna, Daniela Merlotti, Lanfranco D'Elia, Francesca De Pascale, Séverine Guillaume, Loredana Postiglione, Domenico Rendina, Carmine Selleri, Riccardo Muscariello, Simone Bianciardi, Luigi Gennari, Maria Materozzi, Ranuccio Nuti, Margherita Ricciardone, Gianpaolo De Filippo, Rendina, Domenico, De Filippo, Gianpaolo, Postiglione, Loredana, Covelli, Bianca, Ricciardone, Margherita, Guillaume, Séverine, Di Spigna, Gaetano, Selleri, Carmine, Merlotti, Daniela, Bianciardi, Simone, Materozzi, Maria, Muscariello, Riccardo, DE PASCALE, Francesca, Dʼelia, Lanfranco, Nuti, Ranuccio, Strazzullo, Pasquale, and Gennari, Luigi

Subjects
musculoskeletal diseases, 0301 basic medicine, Male, medicine.medical_specialty, Disease, Gastroenterology, Pathogenesis, 03 medical and health sciences, Internal medicine, medicine, Cytokine Receptor gp130, Humans, Interleukin 6, Bone pain, Pathological, Pelvis, Aged, biology, business.industry, Interleukin-6, Interleukin, Middle Aged, Osteitis Deformans, Low back pain, Receptors, Interleukin-6, 030104 developmental biology, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Neurology, biology.protein, Female, Neurology (clinical), medicine.symptom, business, Low Back Pain, Signal Transduction
Abstract

The interleukin (IL)-6 biological system plays a key role in the pathogenesis of Paget disease (PD) of bone and pathological bone pain. Bone pain, particularly in the lower back region, is the most frequent symptom in patients with PD. This case-control study aimed to evaluate the relationship between the IL-6 system and low back pain (LBP) in patients with PD. We evaluated 85 patients with PD, with the disease localized in the lumbar spine, pelvis, and/or sacrum, and classified them based on the presence or absence of LBP, before and after aminobisphosphonate treatment. We also examined 32 healthy controls without LBP. Before treatment, IL-6 levels in patients with PD were higher than those in the controls, without difference between patients with or without LBP. Patients with PD with LBP (35/85) showed higher IL-6-soluble receptor (sIL-6R) and lower soluble glycoprotein (sgp) 130 levels compared with both patients with PD without LBP and controls (sIL-6R: 46.9 ± 7.4 vs 35.4 ± 8.6 vs 29.9 ± 4.2 ng/mL; sgp130: 307.2 ± 35.4 vs 341.4 ± 41.4 vs 417.1 ± 58.5 ng/mL, respectively). Paget disease remission, 6 months after treatment, is associated with LBP improvement. This phenomenon is associated with reduced sIL-6R levels and increased sgp130 levels in patients with PD with LBP at the baseline. Considering the biological properties of IL-6, sIL-6R, and sgp130, the results of the study suggest that the perception of LBP in patients with PD could be linked to an enhanced transmission of IL-6 signal in the specialized neural system activated by nociceptors.

Published
2018

9. Vitamin D and Cardiometabolic Disorders

Author

Riccardo Muscariello, Pasquale Strazzullo, Francesca De Pascale, Daniela De Palma, Anna Fiengo, Domenico Rendina, Gianpaolo De Filippo, Rendina, Domenico, De Filippo, Gianpaolo, Muscariello, Riccardo, DE PALMA, Daniela, Fiengo, Anna, DE PASCALE, Francesca, and Strazzullo, Pasquale

Subjects
medicine.medical_specialty, Pediatrics, Prognosi, Cardiometabolic disorder, Cardiovascular event, vitamin D deficiency, law.invention, Pathogenesis, Pharmacotherapy, Randomized controlled trial, Risk Factors, law, Internal medicine, Cardiovascular Disease, Vitamin D and neurology, Prevalence, Internal Medicine, Humans, Medicine, Vitamin D, High prevalence, Vitamin d supplementation, business.industry, Incidence (epidemiology), Incidence, Risk Factor, Medicine (all), Prognosis, medicine.disease, Vitamin D Deficiency, Endocrinology, Cardiovascular Diseases, business, Cardiology and Cardiovascular Medicine, Human
Abstract

Recent clinical and experimental studies suggest that vitamin D status could play a significant role in the pathogenesis of cardiometabolic disorders as well as in their clinical severity. In particular, low vitamin D levels appear to increase the risk of major cardiovascular events in apparently healthy individuals and to worsen the prognosis quoad vitam and quoad valetudinem following a cardiovascular event. The relevance of these observations is amplified by the high prevalence of vitamin D deficiency and insufficiency that affect over one billion individuals at all ages worldwide. Randomized controlled trials are currently underway in U.S., Europe and Oceania to demonstrate a cause-effect relationship by assessing the effects of vitamin D supplementation on various cardiovascular outcomes. Aim of this review is to point out the more recent advances in knowledge about the relationship between vitamin D status and the incidence, prevalence and pathogenesis of more common cardiometabolic disorders.

Published
2014

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