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329 results on '"De Rosa, Veronica"'

1. Deciphering the role of protein kinase A in the control of FoxP3 expression in regulatory T cells in health and autoimmunity

Author

Lepore, Maria Teresa, Bruzzaniti, Sara, La Rocca, Claudia, Fusco, Clorinda, Carbone, Fortunata, Mottola, Maria, Zuccarelli, Bruno, Lanzillo, Roberta, Brescia Morra, Vincenzo, Maniscalco, Giorgia Teresa, De Simone, Salvatore, Procaccini, Claudio, Porcellini, Antonio, De Rosa, Veronica, Galgani, Mario, Cassano, Silvana, and Matarese, Giuseppe

Published
2024
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5. Interferon Beta-1a treatment promotes SARS-CoV-2 mRNA vaccine response in multiple sclerosis subjects

Author

Maniscalco, Giorgia Teresa, Manzo, Valentino, Ferrara, Anne Lise, Perrella, Alessandro, Di Battista, Mariaelena, Salvatore, Simona, Graziano, Daniela, Viola, Assunta, Amato, Gerardino, Moreggia, Ornella, Di Giulio Cesare, Daniele, Barbato, Stefano, Servillo, Giovanna, Longo, Katia, Di Giovanni, Mario, Scarpati, Barbara, Muggianu, Simona Maria, Longo, Giuseppe, Russo, Giuseppe, Andreone, Vincenzo, and De Rosa, Veronica

Published
2022
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6. Caloric Restriction Promotes Immunometabolic Reprogramming Leading to Protection from Tuberculosis

Author

Palma, Carla, La Rocca, Claudia, Gigantino, Vincenzo, Aquino, Gabriella, Piccaro, Giovanni, Di Silvestre, Dario, Brambilla, Francesca, Rossi, Rossana, Bonacina, Fabrizia, Lepore, Maria Teresa, Audano, Matteo, Mitro, Nico, Botti, Gerardo, Bruzzaniti, Sara, Fusco, Clorinda, Procaccini, Claudio, De Rosa, Veronica, Galgani, Mario, Alviggi, Carlo, Puca, Annibale, Grassi, Fabio, Rezzonico-Jost, Tanja, Norata, Giuseppe Danilo, Mauri, Pierluigi, Netea, Mihai G., de Candia, Paola, and Matarese, Giuseppe

Published
2021
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8. Role of Metabolism in the Immunobiology of Regulatory T Cells

Author

Galgani, Mario, De Rosa, Veronica, La Cava, Antonio, and Matarese, Giuseppe

Subjects
Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Inflammatory and immune system, Animals, Forkhead Transcription Factors, Humans, T-Lymphocytes, Regulatory, Immunology
Abstract

Intracellular metabolism is central to cell activity and function. CD4(+)CD25(+) regulatory T cells (Tregs) that express the transcription factor FOXP3 play a pivotal role in the maintenance of immune tolerance to self. Recent studies showed that the metabolism and function of Tregs are influenced significantly by local environmental conditions and the availability of certain metabolites. It also was reported that defined metabolic programs associate with Treg differentiation, expression of FOXP3, and phenotype stabilization. This article reviews how metabolism modulates FOXP3 expression and Treg function, what environmental factors are involved, and how metabolic manipulation could alter Treg frequency and function in physiopathologic conditions.

Published
2016

9. An immunometabolic pathomechanism for chronic obstructive pulmonary disease

Author

Bruzzaniti, Sara, Bocchino, Marialuisa, Santopaolo, Marianna, Calì, Gaetano, Stanziola, Anna Agnese, D’Amato, Maria, Esposito, Antonella, Barra, Enrica, Garziano, Federica, Micillo, Teresa, Zuchegna, Candida, Romano, Antonella, De Simone, Salvatore, Zuccarelli, Bruno, Mottola, Maria, De Rosa, Veronica, Porcellini, Antonio, Perna, Francesco, Matarese, Giuseppe, and Galgani, Mario

Published
2019

10. Editorial: Inborn Errors of Immunity (IEI) breaking immune homeostasis and tolerance: a key role for T regulatory cells.

Author

De Rosa, Veronica, Sogkas, Georgios, and Bacchetta, Rosa

Subjects
REGULATORY T cells, REGULATORY B cells, IMMUNOLOGIC memory, IMMUNITY, TRANSCRIPTION factors
Abstract

The editorial in Frontiers in Immunology discusses Inborn Errors of Immunity (IEI) and their impact on immune homeostasis and tolerance, with a focus on T regulatory cells. IEI are caused by mutations in genes regulating immune processes, leading to susceptibility to infections and immune-related complications. The article highlights the classification of IEI into 9 groups and introduces the concept of Primary Immune Regulatory Disorders (PIRDs) and Tregopathies. It also explores the role of Tregs in various immune disorders and potential therapeutic approaches for IEI. [Extracted from the article]

Published
2025
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11. The DEL-1/[beta]3 integrin axis promotes regulatory T cell responses during inflammation resolution

Author

Li, Xiaofei, Colamatteo, Alessandra, Kalafati, Lydia, Kajikawa, Tetsuhiro, Wang, Hui, Lim, Jong-Hyung, Bdeir, Khalil, Chung, Kyoung-Jin, Yu, Xiang, Fusco, Clorinda, Porcellini, Antonio, De Simone, Salvatore, Matarese, Giuseppe, Chavakis, Triantafyllos, De Rosa, Veronica, and Hajishengallis, George

Subjects
Care and treatment, Development and progression, Genetic aspects, Health aspects, Inflammation -- Genetic aspects -- Development and progression -- Care and treatment, Integrins -- Health aspects, Immune response -- Genetic aspects, Gene expression -- Health aspects
Abstract

Introduction T cell-mediated immunity entails 2 aspects, proinflammatory and regulatory, which need to be balanced for immune homeostasis (1, 2). For instance, effector [CD4.sup.+] T helper cells expressing IL-17 (Th17 [...], [FOXP3.sup.+][CD4.sup.+] regulatory T cells (Tregs) are critical for immune homeostasis and respond to local tissue cues, which control their stability and function. We explored here whether developmental endothelial locus-1 (DEL-1), which, like Tregs, increases during resolution of inflammation, promotes Treg responses. DEL-1 enhanced Treg numbers and function at barrier sites (oral and lung mucosa). The underlying mechanism was dissected using mice lacking DEL-1 or expressing a point mutant thereof, or mice with T cell-specific deletion of the transcription factor RUNX1, identified by RNA sequencing analysis of the DEL-1-induced Treg transcriptome. Specifically, through interaction with [alpha]v[beta]3 integrin, DEL-1 promoted induction of RUNX1-dependent FOXP3 expression and conferred stability of FOXP3 expression upon Treg restimulation in the absence of exogenous TGF-[beta]1. Consistently, DEL-1 enhanced the demethylation of the Treg-specific demethylated region (TSDR) in the mouse Foxp3 gene and the suppressive function of sorted induced Tregs. Similarly, DEL-1 increased RUNX1 and FOXP3 expression in human conventional T cells, promoting their conversion into induced Tregs with increased TSDR demethylation, enhanced stability, and suppressive activity. We thus uncovered a DEL-1/[alpha]v[beta]3/RUNX1 axis that promotes Treg responses at barrier sites and offers therapeutic options for modulating inflammatory/autoimmune disorders.

Published
2020
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12. Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Author

De Rosa, Veronica, Galgani, Mario, Porcellini, Antonio, Colamatteo, Alessandra, Santopaolo, Marianna, Zuchegna, Candida, Romano, Antonella, De Simone, Salvatore, Procaccini, Claudio, La Rocca, Claudia, Carrieri, Pietro Biagio, Maniscalco, Giorgia Teresa, Salvetti, Marco, Buscarinu, Maria Chiara, Franzese, Adriana, Mozzillo, Enza, La Cava, Antonio, and Matarese, Giuseppe

Subjects
Genetics, Aetiology, 2.1 Biological and endogenous factors, Adult, Alternative Splicing, Autoimmunity, Biomarkers, Tumor, CD4-Positive T-Lymphocytes, Case-Control Studies, DNA-Binding Proteins, Exons, Fatty Acids, Female, Forkhead Transcription Factors, Gene Knockdown Techniques, Genetic Variation, Glycolysis, Humans, In Vitro Techniques, Male, Metabolome, Middle Aged, Multiple Sclerosis, Relapsing-Remitting, Oxidation-Reduction, Phosphopyruvate Hydratase, RNA, Messenger, Receptors, Antigen, T-Cell, Signal Transduction, T-Lymphocytes, Regulatory, Tumor Suppressor Proteins, Young Adult, Immunology
Abstract

Human regulatory T cells (T(reg) cells) that develop from conventional T cells (T(conv) cells) following suboptimal stimulation via the T cell antigen receptor (TCR) (induced T(reg) cells (iT(reg) cells)) express the transcription factor Foxp3, are suppressive, and display an active proliferative and metabolic state. Here we found that the induction and suppressive function of iT(reg) cells tightly depended on glycolysis, which controlled Foxp3 splicing variants containing exon 2 (Foxp3-E2) through the glycolytic enzyme enolase-1. The Foxp3-E2-related suppressive activity of iT(reg) cells was altered in human autoimmune diseases, including multiple sclerosis and type 1 diabetes, and was associated with impaired glycolysis and signaling via interleukin 2. This link between glycolysis and Foxp3-E2 variants via enolase-1 shows a previously unknown mechanism for controlling the induction and function of T(reg) cells in health and in autoimmunity.

Published
2015

13. Type 1 diabetes progression is associated with loss of CD3+CD56+ regulatory T cells that control CD8+ T-cell effector functions

Author

Terrazzano, Giuseppe, Bruzzaniti, Sara, Rubino, Valentina, Santopaolo, Marianna, Palatucci, Anna Teresa, Giovazzino, Angela, La Rocca, Claudia, de Candia, Paola, Puca, Annibale, Perna, Francesco, Procaccini, Claudio, De Rosa, Veronica, Porcellini, Chiara, De Simone, Salvatore, Fattorusso, Valentina, Porcellini, Antonio, Mozzillo, Enza, Troncone, Riccardo, Franzese, Adriana, Ludvigsson, Johnny, Matarese, Giuseppe, Ruggiero, Giuseppina, and Galgani, Mario

Published
2020
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14. Meta-Immunological Profiling of Children With Type 1 Diabetes Identifies New Biomarkers to Monitor Disease Progression

Author

Galgani, Mario, Nugnes, Rosa, Bruzzese, Dario, Perna, Francesco, De Rosa, Veronica, Procaccini, Claudio, Mozzillo, Enza, Cilio, Corrado M, Larsson, Helena Elding, Lernmark, Åke, La Cava, Antonio, Franzese, Adriana, and Matarese, Giuseppe

Subjects
Diabetes, Autoimmune Disease, Nutrition, Clinical Research, Pediatric, Detection, screening and diagnosis, 2.1 Biological and endogenous factors, 4.1 Discovery and preclinical testing of markers and technologies, Aetiology, Metabolic and endocrine, Autoimmunity, Biomarkers, Child, Diabetes Mellitus, Type 1, Disease Progression, Flow Cytometry, Humans, Insulin-Secreting Cells, Monitoring, Immunologic, Prognosis, T-Lymphocytes, Medical and Health Sciences, Endocrinology & Metabolism
Abstract

Type 1 diabetes is characterized by autoimmune destruction of pancreatic β-cells in genetically susceptible individuals. Triggers of islet autoimmunity, time course, and the precise mechanisms responsible for the progressive β-cell failure are not completely understood. The recent escalation of obesity in affluent countries has been suggested to contribute to the increased incidence of type 1 diabetes. Understanding the link between metabolism and immune tolerance could lead to the identification of new markers for the monitoring of disease onset and progression. We studied several immune cell subsets and factors with high metabolic impact as markers associated with disease progression in high-risk subjects and type 1 diabetic patients at onset and at 12 and 24 months after diagnosis. A multiple correlation matrix among different parameters was evaluated statistically and assessed visually on two-dimensional graphs. Markers to predict residual β-cell function up to 1 year after diagnosis were identified in multivariate logistic regression models. The meta-immunological profile changed significantly over time in patients, and a specific signature that was associated with worsening disease was identified. A multivariate logistic regression model measuring age, BMI, fasting C-peptide, number of circulating CD3(+)CD16(+)CD56(+) cells, and the percentage of CD1c(+)CD19(-)CD14(-)CD303(-) type 1 myeloid dendritic cells at disease onset had a significant predictive value. The identification of a specific meta-immunological profile associated with disease status may contribute to our understanding of the basis of diabetes progression.

Published
2013

16. Immunometabolic profiling of T cells from patients with relapsing-remitting multiple sclerosis reveals an impairment in glycolysis and mitochondrial respiration

Author

La Rocca, Claudia, Carbone, Fortunata, De Rosa, Veronica, Colamatteo, Alessandra, Galgani, Mario, Perna, Francesco, Lanzillo, Roberta, Brescia Morra, Vincenzo, Orefice, Giuseppe, Cerillo, Ilaria, Florio, Ciro, Maniscalco, Giorgia Teresa, Salvetti, Marco, Centonze, Diego, Uccelli, Antonio, Longobardi, Salvatore, Visconti, Andrea, and Matarese, Giuseppe

Published
2017
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17. Regulatory T Cell Migration Is Dependent on Glucokinase-Mediated Glycolysis

Author

Kishore, Madhav, Cheung, Kenneth C.P., Fu, Hongmei, Bonacina, Fabrizia, Wang, Guosu, Coe, David, Ward, Eleanor J., Colamatteo, Alessandra, Jangani, Maryam, Baragetti, Andrea, Matarese, Giuseppe, Smith, David M., Haas, Robert, Mauro, Claudio, Wraith, David C., Okkenhaug, Klaus, Catapano, Alberico L., De Rosa, Veronica, Norata, Giuseppe D., and Marelli-Berg, Federica M.

Published
2017
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27. Contributors

Author

Agrawal, Anurag, primary, Antkowiak, Maryellen C., additional, Beck, Melinda A., additional, Bhatia, Sapna, additional, Blaak, Ellen E., additional, Channick, Richard N., additional, Chapman, David, additional, Chaudhuri, Rituparna, additional, De Rosa, Veronica, additional, Dixon, Anne E., additional, Figueroa, Debbie M., additional, Forno, Erick, additional, Goossens, Gijs H., additional, Gordon, Elizabeth M., additional, Green, William D., additional, Gu, Chenjuan, additional, Johnston, Richard A., additional, Jun, Jonathan C., additional, Karlsson, Erik A., additional, King, Gregory, additional, Levine, Stewart J., additional, Marsland, Benjamin J., additional, Matarese, Giuseppe, additional, Milner, J. Justin, additional, Pabelick, Christina, additional, Perna, Francesco, additional, Polotsky, Vsevolod Y., additional, Prakash, Y.S., additional, Procaccini, Claudio, additional, Rastogi, Deepa, additional, Rathore, Aman, additional, Rebeles, Jennifer, additional, Schultz-Cherry, Stacey, additional, Shore, Stephanie A., additional, Sood, Akshay, additional, Stapleton, Renee D., additional, Suratt, Benjamin T., additional, Thompson, Michael A., additional, Ubags, Niki D.J., additional, van Meijel, Rens L.J., additional, Yao, Xianglan, additional, and Younas, Haris, additional

Published
2019
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35. Epigenetics: An opportunity to shape innate and adaptive immune responses

Author

Liotti, Antonietta, primary, Ferrara, Anne Lise, additional, Loffredo, Stefania, additional, Galdiero, Maria Rosaria, additional, Varricchi, Gilda, additional, Di Rella, Francesca, additional, Maniscalco, Giorgia Teresa, additional, Belardo, Martina, additional, Vastano, Roberta, additional, Prencipe, Rosaria, additional, Pignata, Laura, additional, Romano, Roberta, additional, Spadaro, Giuseppe, additional, de Candia, Paola, additional, Pezone, Antonio, additional, and De Rosa, Veronica, additional

Published
2022
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