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1. Predicted Expenditure for Prescription Drugs for Multiple Sclerosis in the Italian Market Between 2023 and 2028: Results of the Oracle Project

Author: Paolicelli, Damiano, Borriello, Giovanna, Clerici, Raffaella, Colombo, Elena, Croce, Davide, D’Amico, Emanuele, De Rossi, Nicola, Di Sapio, Alessia, Fenu, Giuseppe, Maimone, Davide, Marfia, Girolama A., Moccia, Marcello, Perini, Paola, Piscaglia, Maria G., Razzolini, Lorenzo, Riccaboni, Massimo, Signoriello, Elisabetta, Agostoni, Gianluca, Farina, Alberto, Mondino, Margaret, Berruto, Francesco, Tettamanti, Alessia, Donnaloja, Francesca, and Tortorella, Carla
Published: 2024
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2. Signs and symptoms of COVID‐19 in patients with multiple sclerosis

Author: Schiavetti, Irene, Carmisciano, Luca, Ponzano, Marta, Cordioli, Cinzia, Cocco, Eleonora, Marfia, Girolama Alessandra, Inglese, Matilde, Filippi, Massimo, Radaelli, Marta, Bergamaschi, Roberto, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Confalonieri, Paolo, Perini, Paola, Trojano, Maria, Lanzillo, Roberta, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Group, MuSC‐19 Study, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Beatrice Maria Rossi, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Morra, Vincenzo Brescia, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d’Ambrosio, Alessandro, D’Amico, Emanuele, Danni, Maura Chiara, d’Arma, Alessia, Dattola, Vincenzo, de Biase, Stefano, De Luca, Giovanna, De Mercanti, Stefania Federica, De Mitri, Paolo, De Stefano, Nicola, Della Cava, Fabio Maria, Della Cava, Marco, and Di Lemme, Sonia
Subjects: Neurosciences, Multiple Sclerosis, Brain Disorders, Pain Research, Neurodegenerative, Good Health and Well Being, Humans, Aged, COVID-19, Ageusia, SARS-CoV-2, Anosmia, MuSC-19 Study Group, demyelinating diseases, disease-modifying treatment, multiple sclerosis, neurological disorders, Clinical Sciences, Neurology & Neurosurgery
Abstract: Background and purposeClinical outcomes of multiple sclerosis (MS) patients affected by coronavirus disease 2019 (COVID-19) have been thoroughly investigated, but a further analysis on main signs and symptoms and their risk factors still needs attention. The objective of this study was to group together and describe based on similarity the most common signs and symptoms of COVID-19 in MS patients and identify all factors associated with their manifestation.MethodLogistic and linear regression models were run to recognize factors associated with each pooled group of symptoms and their total number.ResultsFrom March 2020 to November 2021, data were collected from 1354 MS patients with confirmed infection of COVID-19. Ageusia and anosmia was less frequent in older people (odds ratio [OR] 0.98; p = 0.005) and more in smoker patients (OR 1.39; p = 0.049). Smoke was also associated with an incremental number of symptoms (OR 1.24; p = 0.031), substance abuse (drugs or alcohol), conjunctivitis and rash (OR 5.20; p = 0.042) and the presence of at least one comorbidity with shortness of breath, tachycardia or chest pain (OR 1.24; p = 0.008). Some disease-modifying therapies were associated with greater frequencies of certain COVID-19 symptoms (association between anti-CD20 therapies and increment in the number of concomitant symptoms: OR 1.29; p = 0.05). Differences in frequencies between the three waves were found for flu-like symptoms (G1, p = 0.024), joint or muscle pain (G2, p = 0.013) and ageusia and anosmia (G5, p
Published: 2022

3. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author: Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Morra, Vincenzo Brescia, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri, Rossi Beatrice Maria, Alteno, Anastasia, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Battaglia, Mario A, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Brescia, Morra Vincenzo, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, d'Ambrosio, Alessandro, and D'Amico, Emanuele
Subjects: Clinical Research, Neurosciences, Multiple Sclerosis, Brain Disorders, Autoimmune Disease, Neurodegenerative, Climate-Related Exposures and Conditions, Good Health and Well Being, Sustainable Cities and Communities, Air Pollution, COVID-19, Humans, Particulate Matter, SARS-CoV-2, MuSC-19 study group, air pollution, coronavirus, multiple sclerosis, Clinical Sciences, Neurology & Neurosurgery
Abstract: Background and purposeSome studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID-19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID-19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID-19 severity amongst PwMS.MethodsData were retrieved from an Italian web-based platform (MuSC-19) which includes PwMS with COVID-19. PM2.5 2016-2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID-19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID-19 severity.ResultsIn all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID-19 course (odds ratio 1.90; p = 0.009).ConclusionsEven if several other factors explain the unfavourable course of COVID-19 in PwMS, the role of air pollutants must be considered and further investigated.
Published: 2022

4. Disease‐Modifying Therapies and Coronavirus Disease 2019 Severity in Multiple Sclerosis

Author: Sormani, Maria P, De Rossi, Nicola, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Trojano, Maria, Zaratin, Paola, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario A, Patti, Francesco, Salvetti, Marco, Nozzolillo, Agostino, Bellacosa, Alessandra, Protti, Alessandra, Di Sapio, Alessia, Signori, Alessio, Petrone, Alfredo, Bisecco, Alvino, Iovino, Aniello, Dutto, Anna, Repice, Anna Maria, Conte, Antonella, Bertolotto, Antonio, Bosco, Antonio, Gallo, Antonio, Zito, Antonio, Sartori, Arianna, Giometto, Bruno, Tortorella, Carla, Antozzi, Carlo, Pozzilli, Carlo, Mancinelli, Chiara Rosa, Zanetta, Chiara, Cordano, Christian, Scandellari, Cinzia, Guaschino, Clara, Gasperini, Claudio, Solaro, Claudio, Fioretti, Cristina, Bezzini, Daiana, Marastoni, Damiano, Paolicelli, Damiano, Vecchio, Domizia, Landi, Doriana, Bucciantini, Elisabetta, Pedrazzoli, Elisabetta, Signoriello, Elisabetta, Sbragia, Elvira, Susani, Emanuela Laura, Curti, Erica, Milano, Eva, Marinelli, Fabiana, Camilli, Federico, Boneschi, Filippo Martinelli, Govone, Flora, Bovis, Francesca, Calabria, Francesca, Caleri, Francesca, Rinaldi, Francesca, Vitetta, Francesca, Corea, Francesco, Crescenzo, Francesco, Teatini, Francesco, Tabiadon, Giulietta, Granella, Franco, Boffa, Giacomo, Lus, Giacomo, Brichetto, Giampaolo, Maniscalco, Giorgia Teresa, Borriello, Giovanna, De Luca, Giovanna, Konrad, Giovanna, Vaula, Giovanna, Marfia, Girolama Alessandra, Mallucci, Giulia, Liberatore, Giuseppe, Salemi, Giuseppe, Miele, Giuseppina, Sibilia, Grazia, Pesci, Ilaria, Brambilla, Laura, Lopiano, Leonardo, Sinisi, Leonardo, Pasquali, Livia, Saraceno, Lorenzo, Chiveri, Luca, Mancinelli, Luca, and Grimaldi, Luigi ME
Subjects: Pneumonia & Influenza, Neurodegenerative, Clinical Research, Autoimmune Disease, Brain Disorders, Lung, Multiple Sclerosis, Pneumonia, Neurosciences, Neurological, Good Health and Well Being, Adolescent, Adult, Aged, Aged, 80 and over, Antibodies, Monoclonal, Humanized, COVID-19, Dimethyl Fumarate, Female, Fingolimod Hydrochloride, Hospitalization, Humans, Immunologic Factors, Immunosuppressive Agents, Intensive Care Units, Interferons, Male, Middle Aged, Mortality, Natalizumab, SARS-CoV-2, Severity of Illness Index, Young Adult, Musc-19 Study Group, Clinical Sciences, Neurology & Neurosurgery
Abstract: ObjectiveThis study was undertaken to assess the impact of immunosuppressive and immunomodulatory therapies on the severity of coronavirus disease 2019 (COVID-19) in people with multiple sclerosis (PwMS).MethodsWe retrospectively collected data of PwMS with suspected or confirmed COVID-19. All the patients had complete follow-up to death or recovery. Severe COVID-19 was defined by a 3-level variable: mild disease not requiring hospitalization versus pneumonia or hospitalization versus intensive care unit (ICU) admission or death. We evaluated baseline characteristics and MS therapies associated with severe COVID-19 by multivariate and propensity score (PS)-weighted ordinal logistic models. Sensitivity analyses were run to confirm the results.ResultsOf 844 PwMS with suspected (n = 565) or confirmed (n = 279) COVID-19, 13 (1.54%) died; 11 of them were in a progressive MS phase, and 8 were without any therapy. Thirty-eight (4.5%) were admitted to an ICU; 99 (11.7%) had radiologically documented pneumonia; 96 (11.4%) were hospitalized. After adjusting for region, age, sex, progressive MS course, Expanded Disability Status Scale, disease duration, body mass index, comorbidities, and recent methylprednisolone use, therapy with an anti-CD20 agent (ocrelizumab or rituximab) was significantly associated (odds ratio [OR] = 2.37, 95% confidence interval [CI] = 1.18-4.74, p = 0.015) with increased risk of severe COVID-19. Recent use (
Published: 2021

5. A multiparametric score for assessing the individual risk of severe Covid-19 among patients with Multiple Sclerosis

Author: Ponzano, Marta, Schiavetti, Irene, Bovis, Francesca, Landi, Doriana, Carmisciano, Luca, De Rossi, Nicola, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Bragadin, Margherita Monti, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Confalonieri, Paolo, Perini, Paola, Bergamaschi, Roberto, Inglese, Matilde, Petracca, Maria, Trojano, Maria, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Fragoso, Yara Dadalti, Sen, Sedat, Siva, Aksel, Karabudak, Rana, Efendi, Husnu, Furlan, Roberto, Salvetti, Marco, and Sormani, Maria Pia
Published: 2022
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6. Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in Italy

Author: Maglione, Alessandro, Sapio, Alessia Di, Signori, Alessio, Laroni, Alice, Iovino, Aniello, Maria Repice, Anna, Mannironi, Antonio, Uccelli, Antonio, Serrati, Carlo, Gabri Nicoletti, Carolina, Lapucci, Caterina, Mancinelli, Chiara Rosa, Cordioli, Cinzia, Bezzini, Daiana, Carmagnini, Daniele, Brogi, Davide, Franciotta, Diego, Landi, Doriana, Nobile Orazio, Eduardo, Cocco, Eleonora, Signoriello, Elisabetta, Nako, Enri, Assandrir, Ester, Marinelli, Fabiana, Baldi, Federica, Ansaldi, Filippo, Bovis, Francesca, Caleri, Francesca, Siciliano, Gabriele, Cola, Gaia, Perego, Germana, Lus, Giacomo, Brichetto, Giampaolo, Icardi, Giancarlo, Bellucci, Gianmarco, Da Rin, Giorgio, Alessandra Marfia, Girolama, Vazzoler, Giulia, Liberatore, Giuseppe, Trivelli, Giuseppe, Callari, Graziella, Gandoglia, Ilaria, Maietta, Ilaria, Schiavetti, Irene, Frau, Jessica, Sticchi, Laura, Pasquali, Livia, Lorefice, Lorena, Carmisciano, Luca, Ruggiero, Lucia, Manzino, Marcello, Salvetti, Marco, Monti Bragadin, Margherita, Chiara Buscarinu, Maria, Gagliardi, Maria, Laura Stromillo, Maria, Pia Sormani, Maria, Ferrò, Maria Teresa, Rilla, Maria Teresa, Clerico, Marinella, Alberto Battaglia, Mario, Ponzano, Marta, Fronza, Marzia, Del Sette, Massimo, Inglese, Matilde, Scialabba, Matteo, Bedognetti, Michele, Ulivelli, Monica, De Rossi, Nicola, De Stefano, Nicola, Gazzola, Paola, Bigi, Rachele, Dubbioso, Raffaele, Reniè, Roberta, Iodice, Rosa, Fabbri, Sabrina, Rasia, Sarah, Rolla, Simona, Platzgummer, Stefan, Cordera, Susanna, Tassinari, Tiziana, Carlini, Valentina, Sormani, Maria Pia, Visconti, Valeria, Stromillo, Maria Laura, Di Sapio, Alessia, Pizzorno, Matteo, Repice, Anna Maria, and Battaglia, Mario Alberto
Published: 2022
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7. Effect of SARS-CoV-2 mRNA vaccination in MS patients treated with disease modifying therapies

Author: Maglione, Alessandro, Di Sapio, Alessia, Signori, Alessio, Laroni, Alice, Iovino, Aniello, Repice, Anna Maria, Mannironi, Antonio, Uccelli, Antonio, Serrati, Carlo, Nicoletti, Carolina Gabri, Lapucci, Caterina, Mancinelli, Chiara Rosa, Cordioli, Cinzia, Bezzini, Daiana, Carmagnini, Daniele, Brogi, Davide, Franciotta, Diego, Landi, Doriana, Orazio, Eduardo Nobile, Cocco, Eleonora, Signoriello, Elisabetta, Nako, Enri, Assandri, Ester, Marinelli, Fabiana, Baldi, Federica, Ansaldi, Filippo, Bovis, Francesca, Caleri, Francesca, Siciliano, Gabriele, Cola, Gaia, Perego, Germana, Lus, Giacomo, Brichetto, Giampaolo, Icardi, Giancarlo, bellucci, gianmarco, Rin, Giorgio Da, Marfia, Girolama Alessandra, Vazzoler, Giulia, Liberatore, Giuseppe, Trivelli, Giuseppe, Callari, Graziella, Gandoglia, Ilaria, Maietta, Ilaria, Schiavetti, Irene, Frau, Jessica, Sticchi, Laura, Pasquali, Livia, Lorefice, Lorena, Carmisciano, Luca, Ruggiero, Lucia, Manzino, Marcello, Salvetti, Marco, Bragadin, Margherita Monti, Buscarinu, Maria Chiara, Gagliardi, Maria, Stromillo, Maria Laura, Sormani, Maria Pia, Ferrò, Maria Teresa, Rilla, Maria Teresa, Clerico, Marinella, Battaglia, Mario Alberto, Ponzano, Marta, Fronza, Marzia, Sette, Massimo Del, Inglese, Matilde, Scialabba, Matteo, Bedognetti, Michele, Ulivelli, Monica, De Rossi, Nicola, De Stefano, Nicola, Gazzola, Paola, Bigi, Rachele, Dubbioso, Raffaele, Reniè, Roberta, Iodice, Rosa, Fabbri, Sabrina, Rasia, Sarah, Rolla, Simona, Platzgummer, Stefan, Cordera, Susanna, Tassinari, Tiziana, Carlini, Valentina, and Da Rin, Giorgio
Published: 2021
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8. Presentation and Outcome in S1P-RM and Natalizumab-Associated Progressive Multifocal Leukoencephalopathy: A Multicenter Cohort Study.

Author: Blant, Julie C., De Rossi, Nicola N., Gold, Ralf, Maurousset, Aude, Kraemer, Markus, Romero-Pinel, Lucía, Misu, Tatsuro, Ouallet, Jean-Christophe, Guyot, Maud Pallix, Gerevini, Simonetta, Bakirtzis, Christos, Piñar Morales, Raquel, Vlad, Benjamin, Karypidis, Panajotis, Moisset, Xavier, Derfuss, Tobias J., Jelcic, Ilijas, Martin-Blondel, Guillaume, Ayzenberg, Ilya, and McGraw, Corey
Published: 2024
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9. RAP: A New Wearable/Portable Device for Extracorporeal Blood Ultrafiltration

Author: Boscariol, Paolo, Boschetti, Giovanni, Via, Aldo Dalla, De Rossi, Nicola, Neri, Mauro, Palomba, Ilaria, Richiedei, Dario, Ronco, Claudio, Trevisani, Alberto, Ceccarelli, Marco, Series Editor, Hernandez, Alfonso, Editorial Board Member, Huang, Tian, Editorial Board Member, Velinsky, Steven A., Editorial Board Member, Takeda, Yukio, Editorial Board Member, Corves, Burkhard, Editorial Board Member, Carbone, Giuseppe, editor, and Gasparetto, Alessandro, editor
Published: 2019
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10. Early use of low dose tocilizumab in patients with COVID-19: A retrospective cohort study with a complete follow-up

Author: De Rossi, Nicola, Scarpazza, Cristina, Filippini, Chiara, Cordioli, Cinzia, Rasia, Sarah, Mancinelli, Chiara Rosa, Rizzoni, Damiano, Romanelli, Giuseppe, Cossi, Stefania, Vettoretto, Nereo, Bove, Sergio, Manfredini, Silvano, Beindorf, Eva Andrea, Mosca, Carlo, Scipione, Vittorio, Flamminio, Gigliola, Albini, Elena Albini, Giansiracusa, Paola, and Capra, Ruggero
Published: 2020
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11. Induction Versus Escalation in Multiple Sclerosis: A 10-Year Real World Study

Author: Prosperini, Luca, Mancinelli, Chiara Rosa, Solaro, Claudio Marcello, Nociti, Viviana, Haggiag, Shalom, Cordioli, Cinzia, De Giglio, Laura, De Rossi, Nicola, Galgani, Simonetta, Rasia, Sarah, Ruggieri, Serena, Tortorella, Carla, Capra, Ruggero, Mirabella, Massimiliano, and Gasperini, Claudio
Published: 2020
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12. Impact of low dose tocilizumab on mortality rate in patients with COVID-19 related pneumonia

Author: Capra, Ruggero, De Rossi, Nicola, Mattioli, Flavia, Romanelli, Giuseppe, Scarpazza, Cristina, Sormani, Maria Pia, and Cossi, Stefania
Published: 2020
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13. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author: Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Abbadessa, Gianmarco, Aguglia, Umberto, Allegorico, Lia, Allegri Rossi, Beatrice Maria, Amato, Maria Pia, Annovazzi, Pietro, Antozzi, Carlo, Appendino, Lucia, Arena, Sebastiano, Baione, Viola, Balgera, Roberto, Barcella, Valeria, Baroncini, Damiano, Barrilà, Caterina, Bellacosa, Alessandra, Bellucci, Gianmarco, Bergamaschi, Roberto, Bergamaschi, Valeria, Bezzini, Daiana, Biolzi, Beatrice, Bisecco, Alvino, Bonavita, Simona, Borriello, Giovanna, Bosa, Chiara, Bosco, Antonio, Bovis, Francesca, Bozzali, Marco, Brambilla, Laura, Buccafusca, Maria, Bucciantini, Elisabetta, Bucello, Sebastiano, Buscarinu, Maria Chiara, Cabboi, Maria Paola, Calabrese, Massimiliano, Calabria, Francesca, Caleri, Francesca, Camilli, Federico, Caniatti, Luisa Maria, Cantello, Roberto, Capra, Ruggero, Capuano, Rocco, Carta, Patrizia, Celani, Maria Grazia, Cellerino, Maria, Cerqua, Raffaella, Chisari, Clara, Clerici, Raffaella, Clerico, Marinella, Cola, Gaia, Conte, Antonella, Conti, Marta Zaffira, Cordano, Christian, Cordera, Susanna, Corea, Francesco, Correale, Claudio, Cottone, Salvatore, Crescenzo, Francesco, Curti, Erica, dʼAmbrosio, Alessandro, DʼAmico, Emanuele, Danni, Maura Chiara, dʼArma, Alessia, Dattola, Vincenzo, de Biase, Stefano, Luca, Giovanna De, Mercanti, Stefania Federica De, De Mitri, Paolo, De Stefano, Nicola, Cava, Marco Della, Napoli, Mario di, Sapio, Alessia Di, Docimo, Renato, Dutto, Anna, Evangelista, Luana, Fanara, Salvatore, Diana, Ferraro, Ferrò, Maria Teresa, Fioretti, Cristina, Fratta, Mario, Frau, Jessica, Fronza, Marzia, Furlan, Roberto, Gajofatto, Alberto, Gallo, Antonio, Gallo, Paolo, Gasperini, Claudio, Ghazaryan, Anna, Giometto, Bruno, Gobbin, Francesca, Govone, Flora, Granella, Franco, Grange, Erica, Grasso, Maria Grazia, Guareschi, Angelica, Guaschino, Clara, Guerrieri, Simone, Guidetti, Donata, Iaffaldano, Pietro, Ianniello, Antonio, Iasevoli, Luigi, Imperiale, Daniele, Infante, Maria Teresa, Iodice, Rosa, Iovino, Aniello, Konrad, Giovanna, Landi, Doriana, Lanzillo, Roberta, Lapucci, Caterina, Lavorgna, Luigi, LʼEpiscopo, Maria Rita, Leva, Serena, Liberatore, Giuseppe, Lo Re, Marianna, Longoni, Marco, Lopiano, Leonardo, Lorefice, Lorena, Lucchini, Matteo, Lus, Giacomo, Maimone, Davide, Malentacchi, Maria, Mallucci, Giulia, Malucchi, Simona, Mancinelli, Chiara Rosa, Mancinelli, Luca, Manganotti, Paolo, Maniscalco, Giorgia Teresa, Mantero, Vittorio, Marangoni, Sabrina, Marastoni, Damiano, Marinelli, Fabiana, Marti, Alessandro, Boneschi, Filippo Martinelli, Masserano Zoli, Federco, Matta, Francesca, Mendozzi, Laura, Meucci, Giuseppe, Miante, Silvia, Miele, Giuseppina, Milano, Eva, Mirabella, Massimiliano, Missione, Rosanna, Moccia, Marcello, Moiola, Lucia, Montepietra, Sara, MontiBragadin, Margherita, Montini, Federico, Motta, Roberta, Nardone, Raffaele, Nicoletti, Carolina Gabri, Nobile-Orazio, Eduardo, Nozzolillo, Agostino, Onofrj, Marco, Orlandi, Riccardo, Palmieri, Anna, Paolicelli, Damiano, Pasquali, Livia, Pastò, Luisa, Pedrazzoli, Elisabetta, Petracca, Maria, Petrone, Alfredo, Piantadosi, Carlo, Pietroboni, Anna M, Pinardi, Federica, Ponzano, Marta, Portaccio, Emilio, Pozzato, Mattia, Pozzilli, Carlo, Prosperini, Luca, Protti, Alessandra, Ragonese, Paolo, Rasia, Sarah, Realmuto, Sabrina, Repice, Anna, Rigoni, Eleonora, Rilla, Maria Teresa, Rinaldi, Francesca, Romano, Calogero Marcello, Ronzoni, Marco, Rovaris, Marco, Ruscica, Francesca, Sabattini, Loredana, Salemi, Giuseppe, Saraceno, Lorenzo, Sartori, Alessia, Sartori, Arianna, Sbragia, Elvira, Scarano, Giuditta Ilaria, Scarano, Valentina, Schillaci, Valentina, Sessa, Maria, Sgarito, Caterina, Sibilia, Grazia, Siciliano, Gabriele, Signori, Alessio, Signoriello, Elisabetta, Sinisi, Leonardo, Sireci, Francesca, Sola, Patrizia, Solaro, Claudio, Sotgiu, Stefano, Sparaco, Maddalena, Stromillo, Maria Laura, Strumia, Silvia, Susani, Emanuela Laura, Tabiadon, Giulietta, Teatini, Francesco, Tomassini, Valentina, Tonietti, Simone, Torri, Clerici Valentina, Tortorella, Carla, Toscano, Simona, Totaro, Rocco, Trotta, Maria, Turano, Gabriella, Ulivelli, Monica, Valentino, Manzo, Vaula, Giovanna, Vecchio, Domizia, Vercellino, Marco, Verrengia, Elena Pinuccia, Vianello, Marika, Virgilio, Eleonora, Vitetta, Francesca, Vollaro, Stefano, Zaffaroni, Mauro, Zampolini, Mauro, Zarbo, Ignazio Roberto, and Zuliani, Luigi
Published: 2022
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14. Four cases of natalizumab-related PML: a less severe course in extended interval dosing?

Author: Scarpazza, Cristina, De Rossi, Nicola, Tabiadon, Giulietta, Turrini, Maria Vittoria, Gerevini, Simonetta, and Capra, Ruggero
Published: 2019
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15. Is maraviroc useful in multiple sclerosis patients with natalizumab-related progressive multifocal leukoencephalopathy?

Author: Scarpazza, Cristina, Prosperini, Luca, Mancinelli, Chiara R., De Rossi, Nicola, Lugaresi, Alessandra, Capobianco, Marco, Moiola, Lucia, Naldi, Paola, Imberti, Luisa, Gerevini, Simonetta, and Capra, Ruggero
Published: 2017
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16. Retrospective comparison clinical presentation and outcome of Natalizumab and Fingolimod-associated PML (P7-3.004)

Author: Bernard-Valnet, Raphael, primary, Blant, Julie, additional, De Rossi, Nicola, additional, Schroeder, Christoph, additional, Maurousset, Aude, additional, Krämer, Markus, additional, Kume, Kodai, additional, Misu, Tatsuro, additional, Ouallet, Jean, additional, Guyot, Maud Pallix, additional, Gold, Ralf, additional, Gerevini, Simonetta, additional, Ayzenberg, Ilya, additional, and Du Pasquier, Renaud, additional
Published: 2023
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17. The effect of air pollution on COVID‐19 severity in a sample of patients with multiple sclerosis

Author: Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria Pia, Gianmarco Abbadessa, Umberto Aguglia, Lia Allegorico, Rossi Beatrice Maria Allegri, Anastasia Alteno, Maria Pia Amato, Pietro Annovazzi, Carlo Antozzi, Lucia Appendino, Sebastiano Arena, Viola Baione, Roberto Balgera, Valeria Barcella, Damiano Baroncini, Caterina Barrilà, Mario A Battaglia, Alessandra Bellacosa, Gianmarco Bellucci, Roberto Bergamaschi, Valeria Bergamaschi, Daiana Bezzini, Beatrice Biolzi, Alvino Bisecco, Simona Bonavita, Giovanna Borriello, Chiara Bosa, Antonio Bosco, Francesca Bovis, Marco Bozzali, Laura Brambilla, Morra Vincenzo Brescia, Giampaolo Brichetto, Maria Buccafusca, Elisabetta Bucciantini, Sebastiano Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano Calabrese, Francesca Calabria, Francesca Caleri, Federico Camilli, Luisa Maria Caniatti, Roberto Cantello, Marco Capobianco, Ruggero Capra, Rocco Capuano, Luca Carmisciano, Patrizia Carta, Paola Cavalla, Maria Grazia Celani, Maria Cellerino, Raffaella Cerqua, Clara Chisari, Raffaella Clerici, Marinella Clerico, Eleonora Cocco, Gaia Cola, Giancarlo Comi, Paolo Confalonieri, Antonella Conte, Marta Zaffira Conti, Christian Cordano, Susanna Cordera, Cinzia Cordioli, Francesco Corea, Claudio Correale, Salvatore Cottone, Francesco Crescenzo, Erica Curti, Alessandro d'Ambrosio, Emanuele D'Amico, Maura Chiara Danni, Alessia d'Arma, Vincenzo Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Renato Docimo, Anna Dutto, Luana Evangelista, Salvatore Fanara, Diana Ferraro, Maria Teresa Ferrò, Massimo Filippi, Cristina Fioretti, Mario Fratta, Jessica Frau, Marzia Fronza, Roberto Furlan, Alberto Gajofatto, Antonio Gallo, Paolo Gallo, Claudio Gasperini, Anna Ghazaryan, Bruno Giometto, Francesca Gobbin, Flora Govone, Franco Granella, Erica Grange, Maria Grazia Grasso, Angelica Guareschi, Clara Guaschino, Simone Guerrieri, Donata Guidetti, Pietro Iaffaldano, Antonio Ianniello, Luigi Iasevoli, Paolo Immovilli, Daniele Imperiale, Maria Teresa Infante, Matilde Inglese, Rosa Iodice, Aniello Iovino, Giovanna Konrad, Doriana Landi, Roberta Lanzillo, Caterina Lapucci, Luigi Lavorgna, Maria Rita L'Episcopo, Serena Leva, Giuseppe Liberatore, Re Marianna Lo, Marco Longoni, Leonardo Lopiano, Lorena Lorefice, Matteo Lucchini, Giacomo Lus, Davide Maimone, Maria Malentacchi, Giulia Mallucci, Simona Malucchi, Chiara Rosa Mancinelli, Luca Mancinelli, Paolo Manganotti, Giorgia Teresa Maniscalco, Vittorio Mantero, Sabrina Marangoni, Damiano Marastoni, Girolama Alessandra Marfia, Fabiana Marinelli, Alessandro Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca Matta, Laura Mendozzi, Giuseppe Meucci, Silvia Miante, Giuseppina Miele, Eva Milano, Massimiliano Mirabella, Rosanna Missione, Marcello Moccia, Lucia Moiola, Sara Montepietra, Margherita MontiBragadin, Federico Montini, Roberta Motta, Raffaele Nardone, Carolina Gabri Nicoletti, Eduardo Nobile-Orazio, Agostino Nozzolillo, Marco Onofrj, Riccardo Orlandi, Anna Palmieri, Damiano Paolicelli, Livia Pasquali, Luisa Pastò, Francesco Patti, Elisabetta Pedrazzoli, Paola Perini, Ilaria Pesci, Maria Petracca, Alfredo Petrone, Carlo Piantadosi, Anna M Pietroboni, Federica Pinardi, Marta Ponzano, Emilio Portaccio, Mattia Pozzato, Carlo Pozzilli, Luca Prosperini, Alessandra Protti, Marta Radaelli, Paolo Ragonese, Sarah Rasia, Sabrina Realmuto, Anna Repice, Eleonora Rigoni, Maria Teresa Rilla, Francesca Rinaldi, Calogero Marcello Romano, Marco Ronzoni, Marco Rovaris, Francesca Ruscica, Loredana Sabattini, Giuseppe Salemi, Marco Salvetti, Lorenzo Saraceno, Alessia Sartori, Arianna Sartori, Elvira Sbragia, Cinzia Scandellari, Giuditta Ilaria Scarano, Valentina Scarano, Irene Schiavetti, Maria Sessa, Caterina Sgarito, Grazia Sibilia, Gabriele Siciliano, Alessio Signori, Elisabetta Signoriello, Leonardo Sinisi, Francesca Sireci, Patrizia Sola, Claudio Solaro, Maria Pia Sormani, Stefano Sotgiu, Maddalena Sparaco, Maria Laura Stromillo, Silvia Strumia, Emanuela Laura Susani, Giulietta Tabiadon, Francesco Teatini, Gioacchino Tedeschi, Valentina Tomassini, Simone Tonietti, Clerici Valentina Torri, Carla Tortorella, Simona Toscano, Rocco Totaro, Maria Trojano, Maria Trotta, Gabriella Turano, Monica Ulivelli, Manzo Valentino, Giovanna Vaula, Domizia Vecchio, Marco Vercellino, Elena Pinuccia Verrengia, Marika Vianello, Eleonora Virgilio, Francesca Vitetta, Stefano Vollaro, Mauro Zaffaroni, Mauro Zampolini, Ignazio Roberto Zarbo, Antonio Zito, Luigi Zuliani, Bergamaschi, R, Ponzano, M, Schiavetti, I, Carmisciano, L, Cordioli, C, Filippi, M, Radaelli, M, Immovilli, P, Capobianco, M, De Rossi, N, Brichetto, G, Cocco, E, Scandellari, C, Cavalla, P, Pesci, I, Zito, A, Confalonieri, P, Marfia, Ga, Perini, P, Inglese, M, Trojano, M, Brescia Morra, V, Pisoni, E, Tedeschi, G, Comi, G, Battaglia, Ma, Patti, F, Salvetti, M, Sormani, Mp, Abbadessa, Gianmarco, Umberto, Aguglia, Lia, Allegorico, Rossi Beatrice Maria Allegri, Anastasia, Alteno, Maria Pia Amato, Pietro, Annovazzi, Carlo, Antozzi, Lucia, Appendino, Sebastiano, Arena, Viola, Baione, Roberto, Balgera, Valeria, Barcella, Damiano, Baroncini, Caterina, Barrilà, Mario, A Battaglia, Alessandra, Bellacosa, Gianmarco, Bellucci, Roberto, Bergamaschi, Valeria, Bergamaschi, Daiana, Bezzini, Beatrice, Biolzi, Bisecco, Alvino, Bonavita, Simona, Giovanna, Borriello, Chiara, Bosa, Bosco, Antonio, Francesca, Bovi, Marco, Bozzali, Laura, Brambilla, Morra Vincenzo Brescia, Giampaolo, Brichetto, Maria, Buccafusca, Elisabetta, Bucciantini, Sebastiano, Bucello, Maria Chiara Buscarinu, Maria Paola Cabboi, Massimiliano, Calabrese, Francesca, Calabria, Francesca, Caleri, Federico, Camilli, Luisa Maria Caniatti, Roberto, Cantello, Marco, Capobianco, Ruggero, Capra, Capuano, Rocco, Luca, Carmisciano, Patrizia, Carta, Paola, Cavalla, Maria Grazia Celani, Maria, Cellerino, Raffaella, Cerqua, Clara, Chisari, Raffaella, Clerici, Marinella, Clerico, Eleonora, Cocco, Gaia, Cola, Giancarlo, Comi, Paolo, Confalonieri, Antonella, Conte, Marta Zaffira Conti, Christian, Cordano, Susanna, Cordera, Cinzia, Cordioli, Corea, Francesco, Claudio, Correale, Salvatore, Cottone, Francesco, Crescenzo, Erica, Curti, Alessandro, D'Ambrosio, Emanuele, D'Amico, Maura Chiara Danni, Alessia, D'Arma, Vincenzo, Dattola, Stefano de Biase, Giovanna De Luca, Stefania Federica De Mercanti, Paolo De Mitri, Nicola De Rossi, Nicola De Stefano, Cava Marco Della, Mario di Napoli, Alessia Di Sapio, Docimo, Renato, Anna, Dutto, Luana, Evangelista, Salvatore, Fanara, Diana, Ferraro, Maria Teresa Ferrò, Massimo, Filippi, Cristina, Fioretti, Fratta, Mario, Jessica, Frau, Marzia, Fronza, Roberto, Furlan, Alberto, Gajofatto, Gallo, Antonio, Paolo, Gallo, Claudio, Gasperini, Anna, Ghazaryan, Bruno, Giometto, Francesca, Gobbin, Flora, Govone, Franco, Granella, Erica, Grange, Maria Grazia Grasso, Angelica, Guareschi, Clara, Guaschino, Simone, Guerrieri, Donata, Guidetti, Pietro, Iaffaldano, Antonio, Ianniello, Luigi, Iasevoli, Paolo, Immovilli, Daniele, Imperiale, Maria Teresa Infante, Matilde, Inglese, Rosa, Iodice, Aniello, Iovino, Giovanna, Konrad, Doriana, Landi, Roberta, Lanzillo, Caterina, Lapucci, Luigi, Lavorgna, Maria Rita L'Episcopo, Serena, Leva, Giuseppe, Liberatore, Re Marianna Lo, Marco, Longoni, Leonardo, Lopiano, Lorena, Lorefice, Matteo, Lucchini, Lus, Giacomo, Davide, Maimone, Maria, Malentacchi, Giulia, Mallucci, Simona, Malucchi, Chiara Rosa Mancinelli, Luca, Mancinelli, Paolo, Manganotti, Giorgia Teresa Maniscalco, Vittorio, Mantero, Sabrina, Marangoni, Damiano, Marastoni, Girolama Alessandra Marfia, Fabiana, Marinelli, Alessandro, Marti, Boneschi Filippo Martinelli, Zoli Federco Masserano, Francesca, Matta, Laura, Mendozzi, Giuseppe, Meucci, Silvia, Miante, Miele, Giuseppina, Eva, Milano, Massimiliano, Mirabella, Missione, Rosanna, Marcello, Moccia, Lucia, Moiola, Sara, Montepietra, Margherita, Montibragadin, Federico, Montini, Roberta, Motta, Raffaele, Nardone, Carolina Gabri Nicoletti, Eduardo, Nobile-Orazio, Agostino, Nozzolillo, Marco, Onofrj, Riccardo, Orlandi, Palmieri, Anna, Damiano, Paolicelli, Livia, Pasquali, Luisa, Pastò, Francesco, Patti, Elisabetta, Pedrazzoli, Paola, Perini, Ilaria, Pesci, Maria, Petracca, Alfredo, Petrone, Carlo, Piantadosi, Anna, M Pietroboni, Federica, Pinardi, Marta, Ponzano, Emilio, Portaccio, Mattia, Pozzato, Carlo, Pozzilli, Luca, Prosperini, Alessandra, Protti, Marta, Radaelli, Paolo, Ragonese, Sarah, Rasia, Sabrina, Realmuto, Anna, Repice, Eleonora, Rigoni, Maria Teresa Rilla, Francesca, Rinaldi, Calogero Marcello Romano, Marco, Ronzoni, Marco, Rovari, Francesca, Ruscica, Loredana, Sabattini, Giuseppe, Salemi, Marco, Salvetti, Lorenzo, Saraceno, Alessia, Sartori, Arianna, Sartori, Elvira, Sbragia, Cinzia, Scandellari, Giuditta Ilaria Scarano, Valentina, Scarano, Irene, Schiavetti, Maria, Sessa, Caterina, Sgarito, Grazia, Sibilia, Gabriele, Siciliano, Alessio, Signori, Signoriello, Elisabetta, Leonardo, Sinisi, Francesca, Sireci, Patrizia, Sola, Claudio, Solaro, Maria Pia Sormani, Stefano, Sotgiu, Sparaco, Maddalena, Maria Laura Stromillo, Silvia, Strumia, Emanuela Laura Susani, Giulietta, Tabiadon, Francesco, Teatini, Tedeschi, Gioacchino, Valentina, Tomassini, Simone, Tonietti, Clerici Valentina Torri, Carla, Tortorella, Simona, Toscano, Rocco, Totaro, Maria, Trojano, Trotta, Maria Consiglia, Gabriella, Turano, Monica, Ulivelli, Manzo, Valentino, Giovanna, Vaula, Domizia, Vecchio, Marco, Vercellino, Elena Pinuccia Verrengia, Marika, Vianello, Eleonora, Virgilio, Francesca, Vitetta, Stefano, Vollaro, Mauro, Zaffaroni, Mauro, Zampolini, Ignazio Roberto Zarbo, Zito, Guido Antonio, Bergamaschi, R., Ponzano, M., Schiavetti, I., Carmisciano, L., Cordioli, C., Filippi, M., Radaelli, M., Immovilli, P., Capobianco, M., De Rossi, N., Brichetto, G., Cocco, E., Scandellari, C., Cavalla, P., Pesci, I., Zito, A., Confalonieri, P., Marfia, G. A., Perini, P., Inglese, M., Trojano, M., Brescia Morra, V., Pisoni, E., Tedeschi, G., Comi, G., Battaglia, M. A., Patti, F., Salvetti, M., Sormani, M. P., Bergamaschi, Roberto, Ponzano, Marta, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Pisoni, Enrico, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Salvetti, Marco, Sormani, Maria, Pia, Gianmarco, Abbadessa, Alvino, Bisecco, Simona, Bonavita, Antonio, Bosco, Rocco, Capuano, Francesco, Corea, Renato, Docimo, Mario, Fratta, Antonio, Gallo, Iodice, Rosa, Iovino, Aniello, Lanzillo, Roberta, Giacomo, Lu, Giuseppina, Miele, Rosanna, Missione, Moccia, Marcello, Anna, Palmieri, Elisabetta, Signoriello, Maddalena, Sparaco, Gioacchino, Tedeschi, Maria, Trotta, Antonio, Zito, and Luigi, Zuliani
Subjects: air pollution, coronavirus, multiple sclerosis, medicine.medical_specialty, Multivariate analysis, Coronavirus disease 2019 (COVID-19), Clinical Sciences, Air pollution, Sample (statistics), Neurodegenerative, Settore MED/26, medicine.disease_cause, Autoimmune Disease, law.invention, Sustainable Cities and Communities, Clinical Research, law, Humans, Medicine, Climate-Related Exposures and Conditions, Neurology & Neurosurgery, MuSC-19 study group, SARS-CoV-2, business.industry, Multiple sclerosis, Neurosciences, COVID-19, Retrospective cohort study, Original Articles, medicine.disease, Intensive care unit, Particulate Matter, Air Pollution, Multiple Sclerosis, Brain Disorders, coronaviru, Settore MED/26 - NEUROLOGIA, Good Health and Well Being, Neurology, multiple sclerosi, Emergency medicine, Original Article, Neurology (clinical), Ordered logit, business, Human
Abstract: Background and purpose Some studies have shown that air pollution, often assessed by thin particulate matter with diameter below 2.5 µg/m3 (PM2.5), may contribute to severe COVID‐19 courses, as well as play a role in the onset and evolution of multiple sclerosis (MS). However, the impact of air pollution on COVID‐19 has never been explored specifically amongst patients with MS (PwMS). This retrospective observational study aims to explore associations between PM2.5 and COVID‐19 severity amongst PwMS. Methods Data were retrieved from an Italian web‐based platform (MuSC‐19) which includes PwMS with COVID‐19. PM2.5 2016–2018 average concentrations were provided by the Copernicus Atmospheric Monitoring Service. Italian patients inserted in the platform from 15 January 2020 to 9 April 2021 with a COVID‐19 positive test were included. Ordered logistic regression models were used to study associations between PM2.5 and COVID‐19 severity. Results In all, 1087 patients, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died, were included. Based on the multivariate analysis, higher concentrations of PM2.5 increased the risk of worse COVID‐19 course (odds ratio 1.90; p = 0.009). Conclusions Even if several other factors explain the unfavourable course of COVID‐19 in PwMS, the role of air pollutants must be considered and further investigated., Air pollution, often assessed by particulate matter with diameter below 2.5 µg/m3, may contribute to severe COVID‐19 courses. 1087 patients were included, of whom 13% required hospitalization and 2% were admitted to an intensive care unit or died. Even if several other factors explain the unfavourable course of COVID‐19 in patients with multiple sclerosis, the role of air pollutants must be considered and further investigated.
Published: 2021
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18. Sars-CoV2 infection in pregnant women with multiple sclerosis

Author: Aprea, Maria Grazia, Schiavetti, Irene, Portaccio, Emilio, Ballerini, Chiara, Battaglia, Mario Alberto, Bergamaschi, Roberto, Brichetto, Giampaolo, Bunul, S Destan, Calabrese, Massimiliano, Capobianco, Marco, Cavalla, Paola, Celani, Maria Grazia, Clerico, Marinella, Cocco, Eleonora, Comi, Giancarlo, Confalonieri, Paolo, Conte, Antonella, Cordioli, Cinzia, De Luca, Giovanna, De Rossi, Nicola, Filippi, Massimo, Gumes, Haluk, Immovilli, Paolo, Inglese, Matilde, Karabudak, Rana, Landi, Doriana, Lanzillo, Roberta, L'Episcopo, Maria Rita, Lorefice, Lorena, Mantero, Vittorio, Marangoni, Sabrina, Marfia, Girolama Alessandra, Masciulli, Camilla, Milano, Eva, Moiola, Lucia, Orlandi, Riccardo, Patti, Francesco, Perini, Paola, Pesci, Ilaria, Pucci, Eugenio, Puthenparampil, Marco, Radaelli, Marta, Salvetti, Marco, Sartori, Arianna, Scandellari, Cinzia, Sen, Sedat, Siva, Aksel, Strumia, Silvia, Teatini, Francesco, Tedeschi, Gioacchino, Trojano, Maria, Tutuncu, Melih, Vaula, Giovanna, Sormani, Maria Pia, and Amato, Maria Pia
Subjects: Multiple sclerosis, SARS-CoV-2 infection, COVID-19, COVID-19 outcomes, pregnancy, risk factors, Settore MED/26
Published: 2023

19. RAP: A New Wearable/Portable Device for Extracorporeal Blood Ultrafiltration

Author: Boscariol, Paolo, primary, Boschetti, Giovanni, additional, Via, Aldo Dalla, additional, De Rossi, Nicola, additional, Neri, Mauro, additional, Palomba, Ilaria, additional, Richiedei, Dario, additional, Ronco, Claudio, additional, and Trevisani, Alberto, additional
Published: 2018
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20. Clinical spectrum and IgG subclass analysis of anti-myelin oligodendrocyte glycoprotein antibody-associated syndromes: a multicenter study

Author: Mariotto, Sara, Ferrari, Sergio, Monaco, Salvatore, Benedetti, Maria Donata, Schanda, Kathrin, Alberti, Daniela, Farinazzo, Alessia, Capra, Ruggero, Mancinelli, Chiara, De Rossi, Nicola, Bombardi, Roberto, Zuliani, Luigi, Zoccarato, Marco, Tanel, Raffaella, Bonora, Adriana, Turatti, Marco, Calabrese, Massimiliano, Polo, Alberto, Pavone, Antonino, Grazian, Luisa, Sechi, GianPietro, Sechi, Elia, Urso, Daniele, Delogu, Rachele, Janes, Francesco, Deotto, Luciano, Cadaldini, Morena, Bianchi, Maria Rachele, Cantalupo, Gaetano, Reindl, Markus, and Gajofatto, Alberto
Published: 2017
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21. Age as a risk factor for early onset of natalizumab-related progressive multifocal leukoencephalopathy

Author: Prosperini, Luca, Scarpazza, Cristina, Imberti, Luisa, Cordioli, Cinzia, De Rossi, Nicola, and Capra, Ruggero
Published: 2017
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22. Smouldering multiple sclerosis:the 'real MS'

Author: Giovannoni, Gavin, Popescu, Veronica, Wuerfel, Jens, Hellwig, Kerstin, Iacobeus, Ellen, Jensen, Michael B., García-Domínguez, José Manuel, Sousa, Livia, De Rossi, Nicola, Hupperts, Raymond, Fenu, Giuseppe, Bodini, Benedetta, Kuusisto, Hanna Maija, Stankoff, Bruno, Lycke, Jan, Airas, Laura, Granziera, Cristina, Scalfari, Antonio, Giovannoni, Gavin, Popescu, Veronica, Wuerfel, Jens, Hellwig, Kerstin, Iacobeus, Ellen, Jensen, Michael B., García-Domínguez, José Manuel, Sousa, Livia, De Rossi, Nicola, Hupperts, Raymond, Fenu, Giuseppe, Bodini, Benedetta, Kuusisto, Hanna Maija, Stankoff, Bruno, Lycke, Jan, Airas, Laura, Granziera, Cristina, and Scalfari, Antonio
Abstract: Using a philosophical approach or deductive reasoning, we challenge the dominant clinico-radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease of the central nervous system (CNS). We provide a range of evidence to argue that the ‘real MS’ is in fact driven primarily by a smouldering pathological disease process. In natural history studies and clinical trials, relapses and focal activity revealed by magnetic resonance imaging (MRI) in MS patients on placebo or on disease-modifying therapies (DMTs) were found to be poor predictors of long-term disease evolution and were dissociated from disability outcomes. In addition, the progressive accumulation of disability in MS can occur independently of relapse activity from early in the disease course. This scenario is underpinned by a more diffuse smouldering pathological process that may affect the entire CNS. Many putative pathological drivers of smouldering MS can be potentially modified by specific therapeutic strategies, an approach that may have major implications for the management of MS patients. We hypothesise that therapeutically targeting a state of ‘no evident inflammatory disease activity’ (NEIDA) cannot sufficiently prevent disability accumulation in MS, meaning that treatment should also focus on other brain and spinal cord pathological processes contributing to the slow loss of neurological function. This should also be complemented with a holistic approach to the management of other systemic disease processes that have been shown to worsen MS outcomes.
Published: 2022

23. To do or not to do? plasma exchange and timing of steroid administration in progressive multifocal leukoencephalopathy

Author: Scarpazza, Cristina, Prosperini, Luca, De Rossi, Nicola, Moiola, Lucia, Sormani, Maria Pia, Gerevini, Simonetta, and Capra, Ruggero
Published: 2017
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24. No evidence of beneficial effects of plasmapheresis in natalizumab-associated PML

Author: Landi, Doriana, De Rossi, Nicola, Zagaglia, Sara, Scarpazza, Cristina, Prosperini, Luca, Albanese, Maria, Buttari, Fabio, Mori, Francesco, Marfia, Girolama Alessandra, Sormani, Maria Pia, Capra, Ruggero, and Centonze, Diego
Published: 2017
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25. Experimental investigation of flash weakening in limestone

Author: Tisato, Nicola, Di Toro, Giulio, De Rossi, Nicola, Quaresimin, Marino, and Candela, Thibault
Published: 2012
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26. Anti-SARS-CoV-2 T-stem cell memory persists in ocrelizumab-treated MS patients

Author: Guerrera, Gisella, primary, Mandelli, Alessandra, additional, Finardi, Annamaria, additional, Orrico, Mario, additional, D’Orso, Silvia, additional, Picozza, Mario, additional, Noviello, Maddalena, additional, Beretta, Valeria, additional, Bonetti, Bruno, additional, Calabrese, Massimiliano, additional, Marastoni, Damiano, additional, De Rossi, Nicola, additional, Capra, Ruggero, additional, Salvetti, Marco, additional, Buscarinu, Maria Chiara, additional, Inglese, Matilde, additional, Uccelli, Antonio, additional, Moiola, Lucia, additional, Raposo, Catarina, additional, Muros-Le Rouzic, Erwan, additional, Pedotti, Rosetta, additional, Filippi, Massimo, additional, Bonini, Chiara, additional, Battistini, Luca, additional, Borsellino, Giovanna, additional, and Furlan, Roberto, additional
Published: 2022
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27. Breakthrough SARS-CoV-2 infections after COVID-19 mRNA vaccination in MS patients on disease modifying therapies during the Delta and the Omicron waves in Italy

Author: Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Inglese, Matilde, additional, Carmisciano, Luca, additional, Laroni, Alice, additional, Lapucci, Caterina, additional, Visconti, Valeria, additional, Serrati, Carlo, additional, Gandoglia, Ilaria, additional, Tassinari, Tiziana, additional, Perego, Germana, additional, Brichetto, Giampaolo, additional, Gazzola, Paola, additional, Mannironi, Antonio, additional, Stromillo, Maria Laura, additional, Cordioli, Cinzia, additional, Landi, Doriana, additional, Clerico, Marinella, additional, Signoriello, Elisabetta, additional, Cocco, Eleonora, additional, Frau, Jessica, additional, Ferrò, Maria Teresa, additional, Di Sapio, Alessia, additional, Pasquali, Livia, additional, Ulivelli, Monica, additional, Marinelli, Fabiana, additional, Pizzorno, Matteo, additional, Callari, Graziella, additional, Iodice, Rosa, additional, Liberatore, Giuseppe, additional, Caleri, Francesca, additional, Repice, Anna Maria, additional, Cordera, Susanna, additional, Battaglia, Mario Alberto, additional, Salvetti, Marco, additional, Franciotta, Diego, additional, Uccelli, Antonio, additional, Maglione, Alessandro, additional, Sapio, Alessia Di, additional, Signori, Alessio, additional, Iovino, Aniello, additional, Maria Repice, Anna, additional, Gabri Nicoletti, Carolina, additional, Mancinelli, Chiara Rosa, additional, Bezzini, Daiana, additional, Carmagnini, Daniele, additional, Brogi, Davide, additional, Nobile Orazio, Eduardo, additional, Nako, Enri, additional, Assandrir, Ester, additional, Baldi, Federica, additional, Ansaldi, Filippo, additional, Bovis, Francesca, additional, Siciliano, Gabriele, additional, Cola, Gaia, additional, Lus, Giacomo, additional, Icardi, Giancarlo, additional, Bellucci, Gianmarco, additional, Da Rin, Giorgio, additional, Alessandra Marfia, Girolama, additional, Vazzoler, Giulia, additional, Trivelli, Giuseppe, additional, Maietta, Ilaria, additional, Sticchi, Laura, additional, Lorefice, Lorena, additional, Ruggiero, Lucia, additional, Manzino, Marcello, additional, Monti Bragadin, Margherita, additional, Chiara Buscarinu, Maria, additional, Gagliardi, Maria, additional, Laura Stromillo, Maria, additional, Pia Sormani, Maria, additional, Rilla, Maria Teresa, additional, Alberto Battaglia, Mario, additional, Ponzano, Marta, additional, Fronza, Marzia, additional, Del Sette, Massimo, additional, Scialabba, Matteo, additional, Bedognetti, Michele, additional, De Rossi, Nicola, additional, De Stefano, Nicola, additional, Bigi, Rachele, additional, Dubbioso, Raffaele, additional, Reniè, Roberta, additional, Fabbri, Sabrina, additional, Rasia, Sarah, additional, Rolla, Simona, additional, Platzgummer, Stefan, additional, and Carlini, Valentina, additional
Published: 2022
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28. Smouldering multiple sclerosis : the ‘real MS’

Author: Giovannoni, Gavin, POPESCU, Veronica, Wuerfel, Jens, Hellwig, Kerstin, Iacobeus, Ellen, Jensen, Michael B., Garcia-Dominguez, Jose Manuel, Sousa, Livia, De Rossi, Nicola, Hupperts, Raymond, Fenu, Giuseppe, Bodini, Benedetta, Kuusisto, Hanna-Maija, Stankoff, Bruno, Lycke, Jan, Airas, Laura, Granziera, Cristina, Scalfari, Antonio, Tampere University, and Department of Neurosciences and Rehabilitation
Subjects: progressive multiple sclerosis, mouldering multiple sclerosis, multiple sclerosiss, progression independent of relapse activity, 3124 Neurology and psychiatry
Abstract: Using a philosophical approach or deductive reasoning, we challenge the dominant clinico-radiological worldview that defines multiple sclerosis (MS) as a focal inflammatory disease of the central nervous system (CNS). We provide a range of evidence to argue that the 'real MS' is in fact driven primarily by a smouldering pathological disease process. In natural history studies and clinical trials, relapses and focal activity revealed by magnetic resonance imaging (MRI) in MS patients on placebo or on disease-modifying therapies (DMTs) were found to be poor predictors of long-term disease evolution and were dissociated from disability outcomes. In addition, the progressive accumulation of disability in MS can occur independently of relapse activity from early in the disease course. This scenario is underpinned by a more diffuse smouldering pathological process that may affect the entire CNS. Many putative pathological drivers of smouldering MS can be potentially modified by specific therapeutic strategies, an approach that may have major implications for the management of MS patients. We hypothesise that therapeutically targeting a state of 'no evident inflammatory disease activity' (NEIDA) cannot sufficiently prevent disability accumulation in MS, meaning that treatment should also focus on other brain and spinal cord pathological processes contributing to the slow loss of neurological function. This should also be complemented with a holistic approach to the management of other systemic disease processes that have been shown to worsen MS outcomes. The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: Sanofi Genzyme kindly provided financial support to help adapt and design the figures and for a third party to help coordinate the submission of the manuscript.
Published: 2022

29. Smouldering multiple sclerosis: the ‘real MS’

Author: Giovannoni, Gavin, primary, Popescu, Veronica, additional, Wuerfel, Jens, additional, Hellwig, Kerstin, additional, Iacobaeus, Ellen, additional, Jensen, Michael B., additional, García-Domínguez, José Manuel, additional, Sousa, Livia, additional, De Rossi, Nicola, additional, Hupperts, Raymond, additional, Fenu, Giuseppe, additional, Bodini, Benedetta, additional, Kuusisto, Hanna-Maija, additional, Stankoff, Bruno, additional, Lycke, Jan, additional, Airas, Laura, additional, Granziera, Cristina, additional, and Scalfari, Antonio, additional
Published: 2022
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30. COVID-19 Severity in Multiple Sclerosis

Author: Sormani, Maria Pia, Schiavetti, Irene, Carmisciano, Luca, Cordioli, Cinzia, Filippi, Massimo, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, De Rossi, Nicola, Brichetto, Giampaolo, Cocco, Eleonora, Scandellari, Cinzia, Cavalla, Paola, Pesci, Ilaria, Zito, Antonio, Confalonieri, Paolo, Marfia, Girolama Alessandra, Perini, Paola, Inglese, Matilde, Trojano, Maria, Brescia Morra, Vincenzo, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, and Salvetti, Marco
Subjects: Adult, Male, Multiple Sclerosis, COVID-19, Comorbidity, Middle Aged, Severity of Illness Index, Article, Cohort Studies, Hospitalization, Intensive Care Units, Italy, Risk Factors, Humans, Female, Retrospective Studies
Abstract: Background and Objectives It is unclear how multiple sclerosis (MS) affects the severity of COVID-19. The aim of this study is to compare COVID-19–related outcomes collected in an Italian cohort of patients with MS with the outcomes expected in the age- and sex-matched Italian population. Methods Hospitalization, intensive care unit (ICU) admission, and death after COVID-19 diagnosis of 1,362 patients with MS were compared with the age- and sex-matched Italian population in a retrospective observational case-cohort study with population-based control. The observed vs the expected events were compared in the whole MS cohort and in different subgroups (higher risk: Expanded Disability Status Scale [EDSS] score > 3 or at least 1 comorbidity, lower risk: EDSS score ≤ 3 and no comorbidities) by the χ2 test, and the risk excess was quantified by risk ratios (RRs). Results The risk of severe events was about twice the risk in the age- and sex-matched Italian population: RR = 2.12 for hospitalization (p < 0.001), RR = 2.19 for ICU admission (p < 0.001), and RR = 2.43 for death (p < 0.001). The excess of risk was confined to the higher-risk group (n = 553). In lower-risk patients (n = 809), the rate of events was close to that of the Italian age- and sex-matched population (RR = 1.12 for hospitalization, RR = 1.52 for ICU admission, and RR = 1.19 for death). In the lower-risk group, an increased hospitalization risk was detected in patients on anti-CD20 (RR = 3.03, p = 0.005), whereas a decrease was detected in patients on interferon (0 observed vs 4 expected events, p = 0.04). Discussion Overall, the MS cohort had a risk of severe events that is twice the risk than the age- and sex-matched Italian population. This excess of risk is mainly explained by the EDSS score and comorbidities, whereas a residual increase of hospitalization risk was observed in patients on anti-CD20 therapies and a decrease in people on interferon.
Published: 2021

31. Early detection and favourable outcome of natalizumab-related progressive multifocal leukoencephalopathy (PML) in two multiple sclerosis patients

Author: Cordioli, Cinzia, De Rossi, Nicola, Rasia, Sarah, Lodoli, Giovanni, and Capra, Ruggero
Published: 2015
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32. Ocrelizumab for the Treatment of Multiple Sclerosis: Safety, Efficacy, and Pharmacology

Author: Mancinelli,Chiara Rosa, De Rossi,Nicola, and Capra,Ruggero
Subjects: Therapeutics and Clinical Risk Management
Abstract: Chiara Rosa Mancinelli, Nicola De Rossi, Ruggero Capra Multiple Sclerosis Centre, Spedali Civili di Brescia, Brescia, ItalyCorrespondence: Chiara Rosa MancinelliMultiple Sclerosis Centre - Spedali Civili di Brescia, Via Ciotti, 154, Montichiari (BS), Brescia, 25018, ItalyTel +39 0309963474Fax +39 0309963475Email mancinellichiara86@gmail.comAbstract: The success of selective B-cells depleting therapies, as the anti-CD20 antibodies, in patients with multiple sclerosis (MS) has confirmed that B-cells are critical in the immune pathogenesis of the disease. Ocrelizumab, a humanized monoclonal antibody that selectively targets CD20+ B-cells, profoundly suppresses acute inflammatory disease activity, representing a highly effective therapy for relapsing-remitting multiple sclerosis (RRMS). It is also the first proven therapy able to slow disability progression in primary progressive multiple sclerosis (PPMS), particularly in patients with signs of acute radiological activity before being enrolled. Effectiveness has widely been demonstrated in randomized clinical trials (RCTs), and recently confirmed in open-label extension trials. Here, we review the role of B-cells in MS, the mechanism of action of ocrelizumab, its pharmacokinetics and pharmacodynamics, and the clinical data supporting its use, as well as safety data. We focus on issues related to the maintenance of immunocompetence, essential to ensure an immune response to either a primary infection or a vaccination. Lastly, we discuss about the possible role of ocrelizumab as an exit strategy from natalizumab-treated patients at risk of developing multifocal progressive leukoencephalopathy. In view of using ocrelizumab chronically, collecting long-term safety data and finding strategies to minimize adverse events will be extremely relevant.Keywords: ocrelizumab, anti-CD20 therapies, relapsing-remitting multiple sclerosis, primary progressive multiple sclerosis
Published: 2021

33. Effect of SARS-CoV-2 mRNA vaccination in MS patients treated with disease modifying therapies

Author: Sormani, Maria Pia, primary, Inglese, Matilde, additional, Schiavetti, Irene, additional, Carmisciano, Luca, additional, Laroni, Alice, additional, Lapucci, Caterina, additional, Da Rin, Giorgio, additional, Serrati, Carlo, additional, Gandoglia, Ilaria, additional, Tassinari, Tiziana, additional, Perego, Germana, additional, Brichetto, Giampaolo, additional, Gazzola, Paola, additional, Mannironi, Antonio, additional, Stromillo, Maria Laura, additional, Cordioli, Cinzia, additional, Landi, Doriana, additional, Clerico, Marinella, additional, Signoriello, Elisabetta, additional, Frau, Jessica, additional, Ferrò, Maria Teresa, additional, Di Sapio, Alessia, additional, Pasquali, Livia, additional, Ulivelli, Monica, additional, Marinelli, Fabiana, additional, Callari, Graziella, additional, Iodice, Rosa, additional, Liberatore, Giuseppe, additional, Caleri, Francesca, additional, Repice, Anna Maria, additional, Cordera, Susanna, additional, Battaglia, Mario Alberto, additional, Salvetti, Marco, additional, Franciotta, Diego, additional, Uccelli, Antonio, additional, Maglione, Alessandro, additional, Signori, Alessio, additional, Iovino, Aniello, additional, Nicoletti, Carolina Gabri, additional, Mancinelli, Chiara Rosa, additional, Bezzini, Daiana, additional, Carmagnini, Daniele, additional, Brogi, Davide, additional, Orazio, Eduardo Nobile, additional, Cocco, Eleonora, additional, Nako, Enri, additional, Assandri, Ester, additional, Baldi, Federica, additional, Ansaldi, Filippo, additional, Bovis, Francesca, additional, Siciliano, Gabriele, additional, Cola, Gaia, additional, Lus, Giacomo, additional, Icardi, Giancarlo, additional, bellucci, gianmarco, additional, Rin, Giorgio Da, additional, Marfia, Girolama Alessandra, additional, Vazzoler, Giulia, additional, Trivelli, Giuseppe, additional, Maietta, Ilaria, additional, Sticchi, Laura, additional, Lorefice, Lorena, additional, Ruggiero, Lucia, additional, Manzino, Marcello, additional, Bragadin, Margherita Monti, additional, Buscarinu, Maria Chiara, additional, Gagliardi, Maria, additional, Sormani, Maria Pia, additional, Rilla, Maria Teresa, additional, Ponzano, Marta, additional, Fronza, Marzia, additional, Sette, Massimo Del, additional, Scialabba, Matteo, additional, Bedognetti, Michele, additional, De Rossi, Nicola, additional, De Stefano, Nicola, additional, Bigi, Rachele, additional, Dubbioso, Raffaele, additional, Reniè, Roberta, additional, Fabbri, Sabrina, additional, Rasia, Sarah, additional, Rolla, Simona, additional, Platzgummer, Stefan, additional, and Carlini, Valentina, additional
Published: 2021
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34. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author: Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Landi, Doriana, additional, Carmisciano, Luca, additional, De Rossi, Nicola, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Brescia Morra, Vincenzo, additional, Trojano, Maria, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, Fragoso, Yara Dadalti, additional, Sen, Sedat, additional, Siva, Aksel, additional, Furlan, Roberto, additional, Salvetti, Marco, additional, Abbadessa, Gianmarco, additional, Aguglia, Umberto, additional, Allegorico, Lia, additional, Allegri, Rossi Beatrice Maria, additional, Amato, Maria Pia, additional, Annovazzi, Pietro, additional, Antozzi, Carlo, additional, Appendino, Lucia, additional, Arena, Sebastiano, additional, Baione, Viola, additional, Balgera, Roberto, additional, Barcella, Valeria, additional, Baroncini, Damiano, additional, Barrilà, Caterina, additional, Battaglia, Mario A., additional, Bellacosa, Alessandra, additional, Bellucci, Gianmarco, additional, Bergamaschi, Roberto, additional, Bergamaschi, Valeria, additional, Bezzini, Daiana, additional, Biolzi, Beatrice, additional, Bisecco, Alvino, additional, Bonavita, Simona, additional, Borriello, Giovanna, additional, Bosa, Chiara, additional, Bosco, Antonio, additional, Bovis, Francesca, additional, Bozzali, Marco, additional, Brambilla, Laura, additional, Brescia, Morra Vincenzo, additional, Brichetto, Giampaolo, additional, Buccafusca, Maria, additional, Bucciantini, Elisabetta, additional, Bucello, Sebastiano, additional, Buscarinu, Maria Chiara, additional, Cabboi, Maria Paola, additional, Calabrese, Massimiliano, additional, Calabria, Francesca, additional, Caleri, Francesca, additional, Camilli, Federico, additional, Caniatti, Luisa Maria, additional, Cantello, Roberto, additional, Capra, Ruggero, additional, Capuano, Rocco, additional, Carta, Patrizia, additional, Cavalla, Paola, additional, Celani, Maria Grazia, additional, Cellerino, Maria, additional, Cerqua, Raffaella, additional, Chisari, Clara, additional, Clerici, Raffaella, additional, Clerico, Marinella, additional, Cocco, Eleonora, additional, Cola, Gaia, additional, Confalonieri, Paolo, additional, Conte, Antonella, additional, Conti, Marta Zaffira, additional, Cordano, Christian, additional, Cordera, Susanna, additional, Corea, Francesco, additional, Correale, Claudio, additional, Cottone, Salvatore, additional, Crescenzo, Francesco, additional, Curti, Erica, additional, d’Ambrosio, Alessandro, additional, D’Amico, Emanuele, additional, Danni, Maura Chiara, additional, d’Arma, Alessia, additional, Dattola, Vincenzo, additional, de Biase, Stefano, additional, De Luca, Giovanna, additional, De Mercanti, Stefania Federica, additional, De Mitri, Paolo, additional, De Stefano, Nicola, additional, Della Cava, Marco, additional, di Napoli, Mario, additional, Di Sapio, Alessia, additional, Docimo, Renato, additional, Dutto, Anna, additional, Evangelista, Luana, additional, Fanara, Salvatore, additional, Ferraro, Diana, additional, Ferrò, Maria Teresa, additional, Filippi, Massimo, additional, Fioretti, Cristina, additional, Fratta, Mario, additional, Frau, Jessica, additional, Fronza, Marzia, additional, Gajofatto, Alberto, additional, Gallo, Antonio, additional, Gallo, Paolo, additional, Gasperini, Claudio, additional, Ghazaryan, Anna, additional, Giometto, Bruno, additional, Gobbin, Francesca, additional, Govone, Flora, additional, Granella, Franco, additional, Grange, Erica, additional, Grasso, Maria Grazia, additional, Guareschi, Angelica, additional, Guaschino, Clara, additional, Guerrieri, Simone, additional, Guidetti, Donata, additional, Iaffaldano, Pietro, additional, Ianniello, Antonio, additional, Iasevoli, Luigi, additional, Imperiale, Daniele, additional, Infante, Maria Teresa, additional, Inglese, Matilde, additional, Iodice, Rosa, additional, Iovino, Aniello, additional, Konrad, Giovanna, additional, Lanzillo, Roberta, additional, Lapucci, Caterina, additional, Lavorgna, Luigi, additional, L’Episcopo Maria, Rita, additional, Leva, Serena, additional, Liberatore, Giuseppe, additional, Lo Re, Marianna, additional, Longoni, Marco, additional, Lopiano, Leonardo, additional, Lorefice, Lorena, additional, Lucchini, Matteo, additional, Lus, Giacomo, additional, Maimone, Davide, additional, Malentacchi, Maria, additional, Mallucci, Giulia, additional, Malucchi, Simona, additional, Mancinelli, Chiara Rosa, additional, Mancinelli, Luca, additional, Manganotti, Paolo, additional, Maniscalco, Teresa Giorgia, additional, Mantero, Vittorio, additional, Marangoni, Sabrina, additional, Marastoni, Damiano, additional, Marfia, Alessandra Girolama, additional, Marinelli, Fabiana, additional, Marti, Alessandro, additional, Martinelli Boneschi, Filippo, additional, Masserano Zoli, Federco, additional, Matta, Francesca, additional, Mendozzi, Laura, additional, Meucci, Giuseppe, additional, Miante, Silvia, additional, Miele, Giuseppina, additional, Milano, Eva, additional, Mirabella, Massimiliano, additional, Missione, Rosanna, additional, Moccia, Marcello, additional, Montepietra, Sara, additional, Monti Bragadin, Margherita, additional, Montini, Federico, additional, Motta, Roberta, additional, Nardone, Raffaele, additional, Nicoletti, Carolina Gabri, additional, Nobile-Orazio, Eduardo, additional, Nozzolillo, Agostino, additional, Onofrj, Marco, additional, Orlandi, Riccardo, additional, Palmieri, Anna, additional, Paolicelli, Damiano, additional, Pasquali, Livia, additional, Pastò, Luisa, additional, Pedrazzoli, Elisabetta, additional, Perini, Paola, additional, Pesci, Ilaria, additional, Petracca, Maria, additional, Petrone, Alfredo, additional, Piantadosi, Carlo, additional, Pietroboni, Anna M., additional, Pinardi, Federica, additional, Ponzano, Marta, additional, Portaccio, Emilio, additional, Pozzato, Mattia, additional, Pozzilli, Carlo, additional, Prosperini, Luca, additional, Protti, Alessandra, additional, Ragonese, Paolo, additional, Rasia, Sarah, additional, Realmuto, Sabrina, additional, Repice, Anna, additional, Rigoni, Eleonora, additional, Rilla, Maria Teresa, additional, Rinaldi, Francesca, additional, Romano, Calogero Marcello, additional, Ronzoni, Marco, additional, Rovaris, Marco, additional, Ruscica, Francesca, additional, Sabattini, Loredana, additional, Salemi, Giuseppe, additional, Saraceno, Lorenzo, additional, Sartori, Alessia, additional, Sartori, Arianna, additional, Sbragia, Elvira, additional, Scandellari, Cinzia, additional, Scarano Giuditta, Ilaria, additional, Scarano, Valentina, additional, Schillaci, Valentina, additional, Sessa, Maria, additional, Sgarito, Caterina, additional, Sibilia, Grazia, additional, Siciliano, Gabriele, additional, Signori, Alessio, additional, Signoriello, Elisabetta, additional, Sinisi, Leonardo, additional, Sireci, Francesca, additional, Sola, Patrizia, additional, Solaro, Claudio, additional, Sormani, Maria Pia, additional, Sotgiu, Stefano, additional, Sparaco, Maddalena, additional, Stromillo, Maria Laura, additional, Strumia, Silvia, additional, Susani, Laura Emanuela, additional, Tabiadon, Giulietta, additional, Teatini, Francesco, additional, Tomassini, Valentina, additional, Tonietti, Simone, additional, Torri, Clerici Valentina, additional, Tortorella, Carla, additional, Toscano, Simona, additional, Totaro, Rocco, additional, Trotta, Maria, additional, Turano, Gabriella, additional, Ulivelli, Monica, additional, Valentino, Manzo, additional, Vaula, Giovanna, additional, Vecchio, Domizia, additional, Vercellino, Marco, additional, Verrengia, Elena Pinuccia, additional, Vianello, Marika, additional, Virgilio, Eleonora, additional, Vitetta, Francesca, additional, Vollaro, Stefano, additional, Zaffaroni, Mauro, additional, Zampolini, Mauro, additional, Zarbo, Ignazio Roberto, additional, Zito, Antonio, additional, and Zuliani, Luigi, additional
Published: 2021
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35. sj-docx-1-msj-10.1177_13524585211035318 – Supplemental material for SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study

Author: Sormani, Maria Pia, Schiavetti, Irene, Landi, Doriana, Carmisciano, Luca, De Rossi, Nicola, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Brescia Morra, Vincenzo, Trojano, Maria, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Fragoso, Yara Dadalti, Sen, Sedat, Siva, Aksel, Furlan, Roberto, and Salvetti, Marco
Subjects: FOS: Clinical medicine, 111702 Aged Health Care, FOS: Health sciences, 110904 Neurology and Neuromuscular Diseases
Abstract: Supplemental material, sj-docx-1-msj-10.1177_13524585211035318 for SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study by Maria Pia Sormani, Irene Schiavetti, Doriana Landi, Luca Carmisciano, Nicola De Rossi, Cinzia Cordioli, Lucia Moiola, Marta Radaelli, Paolo Immovilli, Marco Capobianco, Vincenzo Brescia Morra, Maria Trojano, Gioacchino Tedeschi, Giancarlo Comi, Mario Alberto Battaglia, Francesco Patti, Yara Dadalti Fragoso, Sedat Sen, Aksel Siva, Roberto Furlan and Marco Salvetti in Multiple Sclerosis Journal
Published: 2021
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36. Different disease modifying therapies can increase or decrease Covid-19 severity in Multiple Sclerosis (2021)

Author: Sormani, Maria Pia, primary, De Rossi, Nicola, additional, Schiavetti, Irene, additional, Carmisciano, Luca, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Trojano, Maria, additional, Zaratin, Paola, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, and Salvetti, Marco, additional
Published: 2021
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37. COVID-19 Severity in Multiple Sclerosis: Putting Data Into Context

Author: Sormani, Maria Pia, primary, Schiavetti, Irene, additional, Carmisciano, Luca, additional, Cordioli, Cinzia, additional, Filippi, Massimo, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, De Rossi, Nicola, additional, Brichetto, Giampaolo, additional, Cocco, Eleonora, additional, Scandellari, Cinzia, additional, Cavalla, Paola, additional, Pesci, Ilaria, additional, Zito, Antonio, additional, Confalonieri, Paolo, additional, Marfia, Girolama Alessandra, additional, Perini, Paola, additional, Inglese, Matilde, additional, Trojano, Maria, additional, Brescia Morra, Vincenzo, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, and Salvetti, Marco, additional
Published: 2021
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38. SARS-CoV-2 serology after COVID-19 in multiple sclerosis: An international cohort study.

Author: Sormani, Maria Pia, Schiavetti, Irene, Landi, Doriana, Carmisciano, Luca, De Rossi, Nicola, Cordioli, Cinzia, Moiola, Lucia, Radaelli, Marta, Immovilli, Paolo, Capobianco, Marco, Brescia Morra, Vincenzo, Trojano, Maria, Tedeschi, Gioacchino, Comi, Giancarlo, Battaglia, Mario Alberto, Patti, Francesco, Fragoso, Yara Dadalti, Sen, Sedat, Siva, Aksel, and Furlan, Roberto
Subjects: COVID-19, MULTIPLE sclerosis, SERODIAGNOSIS, SARS-CoV-2, HUMORAL immunity
Abstract: Background: The MuSC-19 project is an Italian cohort study open to international partners that collects data on multiple sclerosis (MS) patients with COVID-19. During the second wave of the pandemic, serological tests became routinely available. Objective: To evaluate the seroprevalence of anti-SARS-CoV-2 antibodies according to the use of disease-modifying therapy (DMT) in a subset of patients included in the MuSC-19 data set who had undergone a serological test. Methods: We evaluated the association between positive serological test results and time elapsed since infection onset, age, sex, Expanded Disability Status Scale score, comorbidities and DMT exposure using a multivariable logistic model. Results: Data were collected from 423 patients (345 from Italy, 61 from Turkey and 17 from Brazil) with a serological test performed during follow-up. Overall, 325 out of 423 tested patients (76.8%) had a positive serological test. At multivariate analysis, therapy with anti-CD20 was significantly associated with a reduced probability of developing antibodies after COVID-19 (odds ratio (OR) = 0.20, p = 0.002). Conclusion: Patients with MS maintain the capacity to develop humoral immune response against SARS-COV-2, although to a lesser extent when treated with anti-CD20 drugs. Overall, our results are reassuring with respect to the possibility to achieve sufficient immunization with vaccination. [ABSTRACT FROM AUTHOR]
Published: 2022
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39. Switching to ocrelizumab in RRMS patients at risk of PML previously treated with extended interval dosing of natalizumab

Author: Mancinelli, Chiara Rosa, primary, Scarpazza, Cristina, additional, Cordioli, Cinzia, additional, De Rossi, Nicola, additional, Rasia, Sarah, additional, Turrini, Maria Vittoria, additional, and Capra, Ruggero, additional
Published: 2020
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40. Minimal evidence of disease activity (MEDA) in relapsing-remitting multiple sclerosis

Author: Prosperini, Luca, primary, Mancinelli, Chiara, additional, Haggiag, Shalom, additional, Cordioli, Cinzia, additional, De Giglio, Laura, additional, De Rossi, Nicola, additional, Galgani, Simonetta, additional, Rasia, Sarah, additional, Ruggieri, Serena, additional, Tortorella, Carla, additional, Pozzilli, Carlo, additional, and Gasperini, Claudio, additional
Published: 2020
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41. Disease Modifying Therapies and COVID-19 Severity in Multiple Sclerosis

Author: Sormani, Maria Pia, primary, De Rossi, Nicola, additional, Schiavetti, Irene, additional, Carmisciano, Luca, additional, Cordioli, Cinzia, additional, Moiola, Lucia, additional, Radaelli, Marta, additional, Immovilli, Paolo, additional, Capobianco, Marco, additional, Trojano, Maria, additional, Zaratin, Paola, additional, Tedeschi, Gioacchino, additional, Comi, Giancarlo, additional, Battaglia, Mario Alberto, additional, Patti, Francesco, additional, and Salvetti, Marco, additional
Published: 2020
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42. Early diagnosis of progressive multifocal leucoencephalopathy: Longitudinal lesion evolution

Author: Scarpazza, Cristina, Signori, Alessio, Prosperini, Luca, Sormani, Maria Pia, Cosottini, Mirco, Capra, Ruggero, Gerevini, Simonetta, Altieri, Marta, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Morra, Vincenzo Brescia, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Chiusole, Maurizia, Clerico, Marinella, Cordioli, Cinzia, D'Aleo, Giangaetano, De Luca, Giovanna, De Riz, Milena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrante, Claudio, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Palmeri, Barbara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Rezzonico, Monica, Rottoli, Maria Rosa, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Stenta, Gianola, Tabiadon, Giulietta, Tortorella, Carla, Trojano, Maria, Valentino, Paola, Rottoli, Maira Rosa, Scarpazza, C, Signori, A, Prosperini, L, Sormani, M, Cosottini, M, Capra, R, Gerevini, S, Altieri, M, Amato, M, Artusi, C, Bandini, F, Barcella, V, Bertolotto, A, Morra, V, Capobianco, M, Cavaletti, G, Cavalla, P, Centonze, D, Chiusole, M, Clerico, M, Cordioli, C, D'Aleo, G, De Luca, G, De Riz, M, De Rossi, N, Deotto, L, Durelli, L, Falcini, M, Ferrante, C, Ferrari, E, Fusco, M, Gasperini, C, Ghezzi, A, Grimaldi, L, Guidotti, M, Laroni, A, Lugaresi, A, Moiola, L, Naldi, P, Pane, C, Palmeri, B, Perrone, P, Pizzorno, M, Pozzilli, C, Rezzonico, M, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santuccio, G, Scarpini, E, Sessa, E, Solaro, C, Stenta, G, Tabiadon, G, Tortorella, C, Trojano, M, and Valentino, P
Subjects: natalizumab treatment, Adult, Male, medicine.medical_specialty, Multiple Sclerosis, Surgery, Neurology (clinical), Psychiatry and Mental Health, natalizumab, progressive multifocal leucoencephalopathy, Progressive Multifocal, Lesion, Leukoencephalopathy, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Psychiatry and Mental Health, progressive multifocal leucoencephalopathy, medicine, Humans, Immunologic Factors, Young adult, Progressive multifocal leucoencephalopathy, Retrospective Studies, medicine.diagnostic_test, business.industry, Multiple sclerosis, Natalizumab, Leukoencephalopathy, Progressive Multifocal, Magnetic resonance imaging, Retrospective cohort study, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Early Diagnosis, Female, Italy, Cohort, Settore MED/26 - Neurologia, Radiology, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: ObjectiveEarly diagnosis of natalizumab-related progressive multifocal leucoencephalopathy (NTZ-PML) in multiple sclerosis has been deemed a major priority by the regulatory agencies but has yet to become a reality. The current paper aims to: (1) investigate whether patients with NTZ-PML pass through a prolonged presymptomatic phase with MRI abnormalities, (2) estimate the longitudinal PML lesion volume increase during the presymptomatic phase and (3) estimate the presymptomatic phase length and its impact on therapy duration as a risk stratification parameter.MethodsAll Italian patients who developed NTZ-PML between 2009 and 2018 were included. The data of patients with available prediagnostic MRI were analysed (n=41). Detailed clinical and neuroradiological information was available for each participant.Results(1) PML lesions were detectable in the presymptomatic phase in 32/41 (78%) patients; (ii) the lesion volume increased by 62.8 % for each month spent in the prediagnostic phase; (3) the prediagnostic phase length was 150.8±74.9 days; (4) PML MRI features were detectable before the 24th month of therapy in 31.7 % of patients in our cohort.ConclusionsConsidering the latency of PML clinical manifestation, the presymptomatic phase length supports the usefulness of MRI surveillance every 3–4 months. Early diagnosis could prompt a better outcome for patients due to the relationship between lesion volume and JC virus infection. The insight from this study might also have an impact on risk stratification algorithms, as therapy duration as a parameter of stratification appears to need reassessment.
Published: 2019

43. Early diagnosis of progressive multifocal leucoencephalopathy: Longitudinal lesion evolution

Author: Scarpazza, C, Signori, A, Prosperini, L, Sormani, M, Cosottini, M, Capra, R, Gerevini, S, Altieri, M, Amato, M, Artusi, C, Bandini, F, Barcella, V, Bertolotto, A, Morra, V, Capobianco, M, Cavaletti, G, Cavalla, P, Centonze, D, Chiusole, M, Clerico, M, Cordioli, C, D'Aleo, G, De Luca, G, De Riz, M, De Rossi, N, Deotto, L, Durelli, L, Falcini, M, Ferrante, C, Ferrari, E, Fusco, M, Gasperini, C, Ghezzi, A, Grimaldi, L, Guidotti, M, Laroni, A, Lugaresi, A, Moiola, L, Naldi, P, Pane, C, Palmeri, B, Perrone, P, Pizzorno, M, Pozzilli, C, Rezzonico, M, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santuccio, G, Scarpini, E, Sessa, E, Solaro, C, Stenta, G, Tabiadon, G, Tortorella, C, Trojano, M, Valentino, P, Scarpazza, Cristina, Signori, Alessio, Prosperini, Luca, Sormani, Maria Pia, Cosottini, Mirco, Capra, Ruggero, Gerevini, Simonetta, Altieri, Marta, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Morra, Vincenzo Brescia, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Chiusole, Maurizia, Clerico, Marinella, Cordioli, Cinzia, D'Aleo, Giangaetano, De Luca, Giovanna, De Riz, Milena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrante, Claudio, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Palmeri, Barbara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Rezzonico, Monica, Rottoli, Maria Rosa, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Stenta, Gianola, Tabiadon, Giulietta, Tortorella, Carla, Trojano, Maria, Valentino, Paola, Rottoli, Maira Rosa, Scarpazza, C, Signori, A, Prosperini, L, Sormani, M, Cosottini, M, Capra, R, Gerevini, S, Altieri, M, Amato, M, Artusi, C, Bandini, F, Barcella, V, Bertolotto, A, Morra, V, Capobianco, M, Cavaletti, G, Cavalla, P, Centonze, D, Chiusole, M, Clerico, M, Cordioli, C, D'Aleo, G, De Luca, G, De Riz, M, De Rossi, N, Deotto, L, Durelli, L, Falcini, M, Ferrante, C, Ferrari, E, Fusco, M, Gasperini, C, Ghezzi, A, Grimaldi, L, Guidotti, M, Laroni, A, Lugaresi, A, Moiola, L, Naldi, P, Pane, C, Palmeri, B, Perrone, P, Pizzorno, M, Pozzilli, C, Rezzonico, M, Rottoli, M, Rovaris, M, Salemi, G, Salvetti, M, Santuccio, G, Scarpini, E, Sessa, E, Solaro, C, Stenta, G, Tabiadon, G, Tortorella, C, Trojano, M, Valentino, P, Scarpazza, Cristina, Signori, Alessio, Prosperini, Luca, Sormani, Maria Pia, Cosottini, Mirco, Capra, Ruggero, Gerevini, Simonetta, Altieri, Marta, Amato, Maria Pia, Artusi, Carlo Alberto, Bandini, Fabio, Barcella, Valeria, Bertolotto, Antonio, Morra, Vincenzo Brescia, Capobianco, Marco, Cavaletti, Guido, Cavalla, Paola, Centonze, Diego, Chiusole, Maurizia, Clerico, Marinella, Cordioli, Cinzia, D'Aleo, Giangaetano, De Luca, Giovanna, De Riz, Milena, De Rossi, Nicola, Deotto, Luciano, Durelli, Luca, Falcini, Mario, Ferrante, Claudio, Ferrari, Ernesta, Fusco, Maria Luisa, Gasperini, Claudio, Ghezzi, Angelo, Grimaldi, Luigi, Guidotti, Mario, Laroni, Alice, Lugaresi, Alessandra, Moiola, Lucia, Naldi, Paola, Pane, Chiara, Palmeri, Barbara, Perrone, Patrizia, Pizzorno, Matteo, Pozzilli, Carlo, Rezzonico, Monica, Rottoli, Maria Rosa, Rovaris, Marco, Salemi, Giuseppe, Salvetti, Marco, Santuccio, Giuseppe, Scarpini, Elio, Sessa, Edoardo, Solaro, Claudio, Stenta, Gianola, Tabiadon, Giulietta, Tortorella, Carla, Trojano, Maria, Valentino, Paola, and Rottoli, Maira Rosa
Abstract: Objective early diagnosis of natalizumab-related progressive multifocal leucoencephalopathy (NTZ-pML) in multiple sclerosis has been deemed a major priority by the regulatory agencies but has yet to become a reality. The current paper aims to: (1) investigate whether patients with NTZ-pML pass through a prolonged presymptomatic phase with MRI abnormalities, (2) estimate the longitudinal pML lesion volume increase during the presymptomatic phase and (3) estimate the presymptomatic phase length and its impact on therapy duration as a risk stratification parameter. Methods all Italian patients who developed NTZ-pML between 2009 and 2018 were included. The data of patients with available prediagnostic MRI were analysed (n=41). Detailed clinical and neuroradiological information was available for each participant. results (1) pML lesions were detectable in the presymptomatic phase in 32/41 (78%) patients; (ii) the lesion volume increased by 62.8 % for each month spent in the prediagnostic phase; (3) the prediagnostic phase length was 150.8±74.9 days; (4) pML MRI features were detectable before the 24th month of therapy in 31.7 % of patients in our cohort. Conclusions considering the latency of pML clinical manifestation, the presymptomatic phase length supports the usefulness of MRI surveillance every 3-4 months. early diagnosis could prompt a better outcome for patients due to the relationship between lesion volume and Jc virus infection. The insight from this study might also have an impact on risk stratification algorithms, as therapy duration as a parameter of stratification appears to need reassessment.
Published: 2019

44. DMTs and Covid‐19 severity in MS: a pooled analysis from Italy and France.

Author: Sormani, Maria Pia, Salvetti, Marco, Labauge, Pierre, Schiavetti, Irene, Zephir, Helene, Carmisciano, Luca, Bensa, Caroline, De Rossi, Nicola, Pelletier, Jean, Cordioli, Cinzia, Vukusic, Sandra, Moiola, Lucia, Kerschen, Philippe, Radaelli, Marta, Théaudin, Marie, Immovilli, Paolo, Casez, Olivier, Capobianco, Marco, Ciron, Jonathan, and Trojano, Maria
Subjects: COVID-19, INTERFERONS
Abstract: We evaluated the effect of DMTs on Covid‐19 severity in patients with MS, with a pooled‐analysis of two large cohorts from Italy and France. The association of baseline characteristics and DMTs with Covid‐19 severity was assessed by multivariate ordinal‐logistic models and pooled by a fixed‐effect meta‐analysis. 1066 patients with MS from Italy and 721 from France were included. In the multivariate model, anti‐CD20 therapies were significantly associated (OR = 2.05, 95%CI = 1.39–3.02, p < 0.001) with Covid‐19 severity, whereas interferon indicated a decreased risk (OR = 0.42, 95%CI = 0.18–0.99, p = 0.047). This pooled‐analysis confirms an increased risk of severe Covid‐19 in patients on anti‐CD20 therapies and supports the protective role of interferon. [ABSTRACT FROM AUTHOR]
Published: 2021
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45. Natalizumab is associated with early improvement of working ability in relapsing-remitting multiple sclerosis patients: WANT observational study results.

Author: Capra, Ruggero, Morra, Vincenzo Brescia, Mirabella, Massimiliano, Gasperini, Claudio, Scandellari, Cinzia, Totaro, Rocco, De Rossi, Nicola, Masera, Silvia, Zipoli, Valentina, and Patti, Francesco
Subjects: LABOR productivity, MULTIPLE sclerosis, DISEASE relapse, NATALIZUMAB, SCIENTIFIC observation
Abstract: Background: The Work Ability in Natalizumab-Treated MS Patients (WANT) study assessed work ability, quality of life, and cognitive processing speed during natalizumab treatment. Methods: WANT was a 1-year, prospective, multicenter observational study conducted in Italy. Inclusion criteria included relapsing-remitting multiple sclerosis (MS), natalizumab treatment, full-time worker status, and loss of working hours due to MS as measured by the Work Productivity and Activity Impairment Questionnaire for MS (WPAI:MS). The primary endpoint was change in WPAI:MS domain scores after 1 year on natalizumab. Secondary endpoints included change in annualized relapse rate (ARR), Multiple Sclerosis Impact Scale (MSIS-29) score, and Symbol Digit Modalities Test (SDMT) score. Results: At enrollment, the 91 patients had a mean age of 38.3 (standard deviation [SD], 9.0) years and a mean ARR of 1.5 (SD, 0.8). After 1 year, improvements were observed in all WPAI:MS domains, with significant reductions in Absenteeism (−4.2 [SD, 26.0], p = 0.0190) and Work Productivity Loss (−7.2 [SD, 28.6]; p = 0.0456). These changes were accompanied by a low ARR (0.1), and 87.9% of patients were relapse free. Significant improvement was observed in MSIS-29 physical and psychological domains (reductions of 2.8 [SD, 11.6; p = 0.0295] and 6.3 [SD, 15.6; p = 0.0007], respectively) and SDMT score (increase of 2.4 [SD, 7.9; p = 0.0006]). Adverse events were reported in 32 of 104 patients (30.8%). Conclusions: The reductions in Absenteeism and Work Productivity Loss and the improved physical and psychological functioning reported after 1 year of natalizumab treatment in real-world settings extend our understanding of natalizumab's effects on patient-centric and health economics outcomes. [ABSTRACT FROM AUTHOR]
Published: 2021
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46. Tolerability and persistence in therapy with PEGylated-IFN: results from a multicentric observational study in northern Italy

Author: Simone Tonietti, Damiano Baroncini, DE ROSSI NICOLA, Giulia Mallucci, and Pietro Annovazzi
Published: 2018
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47. Alemtuzumab in highly active MS: effectiveness in real life and the need of immunological profiling

Author: Ruggero Capra, Chiara Rosa Mancinelli, Diego Bertoli, and DE ROSSI NICOLA
Published: 2018
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48. Age influences lymphopenia in MS patients treated with dimethyl-fumarate

Author: Ruggero Capra, DE ROSSI NICOLA, Cristina Scarpazza, and Chiara Rosa Mancinelli
Published: 2018
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49. Impact of natural menopause on multiple sclerosis: a multicentre study

Author: Baroncini, Damiano, primary, Annovazzi, Pietro Osvaldo, additional, De Rossi, Nicola, additional, Mallucci, Giulia, additional, Torri Clerici, Valentina, additional, Tonietti, Simone, additional, Mantero, Vittorio, additional, Ferrò, Maria Teresa, additional, Messina, Maria Josè, additional, Barcella, Valeria, additional, La Mantia, Loredana, additional, Ronzoni, Marco, additional, Barrilà, Caterina, additional, Clerici, Raffaella, additional, Susani, Emanuela Laura, additional, Fusco, Maria Letizia, additional, Chiveri, Luca, additional, Abate, Lucia, additional, Ferraro, Ottavia, additional, Capra, Ruggero, additional, Colombo, Elena, additional, Confalonieri, Paolo, additional, and Zaffaroni, Mauro, additional
Published: 2019
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50. Description and In-Vitro Test Results of a New Wearable/Portable Device for Extracorporeal Blood Ultrafiltration

Author: Boscariol, Paolo, primary, Boschetti, Giovanni, additional, Dalla Via, Aldo, additional, De Rossi, Nicola, additional, Neri, Mauro, additional, Palomba, Ilaria, additional, Richiedei, Dario, additional, Ronco, Claudio, additional, and Trevisani, Alberto, additional
Published: 2019
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