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1. OC.15.3: INCIDENCE AND CHARACTERISTICS OF ENDOSCOPIC GASTRIC POLYPS IN PATIENTS WITH AUTOIMMUNE ATROPHIC GASTRITIS: A MULTICENTRIC RETROSPECTIVE STUDY

Author

Massironi, S., primary, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M.V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional

Published
2024
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2. Assessing the Frequency of Type I Gastric Neuroendocrine Neoplasms in Autoimmune Atrophic Gastritis: A Multi-Center Study in Italy

Author

Massironi, S., additional, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M. V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional

Published
2024
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3. Incidence and Characteristics of Endoscopic Gastric Polyps in Patients with Autoimmune Atrophic Gastritis: A Multicentric Retrospective Study

Author

Massironi, S., additional, Gallo, C., additional, Lahner, E., additional, Sciola, V., additional, Cavalcoli, F., additional, Lenti, M. V., additional, Miceli, E., additional, Zilli, A., additional, Dottori, L., additional, De Rossi, G., additional, Annibale, B., additional, Vecchi, M., additional, Cantù, P., additional, Di Sabatino, A., additional, Invernizzi, P., additional, and Danese, S., additional

Published
2024
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5. Translational and transdisciplinary approach to the human papilloma virus - Preliminary evidence from the Italian 'HPV board: a future without papilloma virus' project

Author

Tatullo M., Rengo S., Mortellaro C., Riva Cavalletti De Rossi G., Riva F., Tatullo, M., Rengo, S., Mortellaro, C., Riva Cavalletti De Rossi, G., and Riva, F.

Abstract

Human papillomavirus (HPV) is considered to be one of the viral infections associated with cancers and other diseases. HPV is detected asymptomatically in the oral mucosa. The presence of human papillomavirus in the oral mucosa appears to be closely associated with a series of benign and malign oral lesions. The aim of this paper is to report the Italian experience in applying translational protocols, using new technologies and multidisciplinary strategies in Human Papilloma virus detection and treatment. The "HPV board: a future without papilloma virus" project was born, promoted by CNEL (Italian Council of Economics and Labor) with the collaboration of numerous scientific societies to commonly approach to public knowledge of HPV-related oral lesions and their clinical management. The preliminary results are related to the assessment of the proof-of-concept of this new project. More in details, "HPV Board" is a project that plans the presence of a working group, made up of otolaryngologists, dentists, oral and maxillofacial surgeons, in close contact with gynecologists, oncologists and pediatricians; this working group manages to combine very transversal skills, in order to promote primary prevention projects, early diagnosis and adequate therapies. The "HPV BOARD" project will give the opportunity to increase the attention of patients and doctors on the early diagnosis of oncological diseases dependent on infection by the infectious agent HPV. In this panorama, dentists will have the role of "first sentinel" of public health because oral health is an indicator, too often overlooked, for the prevention of numerous diseases.

Published
2023

12. OC.04.6 IMPROVING ENDOSCOPIC ASSESSMENT AND MANAGEMENT OF LARGE NON-PEDUNCOLATED COLORECTAL LESIONS IN A WESTERN CENTER OVER 10 YEARS: LESSONS LEARNT AND IMPACT ON PATIENTS' OUTCOMES

Author

Vanella, G., primary, Coluccio, C., additional, Antonelli, G., additional, Angeletti, S., additional, Micheli, F., additional, Barbato, A., additional, De Rossi, G., additional, Marchetti, A., additional, Mereu, E., additional, Pepe, P., additional, Corleto, V.D., additional, D'Ambra, G., additional, Ruggeri, M., additional, and Di Giulio, E., additional

Published
2020
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16. Translational and transdisciplinary approach to the human papilloma virus – Preliminary evidence from the Italian “HPV board: a future without papilloma virus” project.

Author

TATULLO, M., RENGO, S., MORTELLARO, C., RIVA CAVALLETTI DE ROSSI, G., and RIVA, F.

Abstract

Human papillomavirus (HPV) is considered to be one of the viral infections associated with cancers and other diseases. HPV is detected asymptomatically in the oral mucosa. The presence of human papillomavirus in the oral mucosa appears to be closely associated with a series of benign and malign oral lesions. The aim of this paper is to report the Italian experience in applying translational protocols, using new technologies and multidisciplinary strategies in Human Papilloma virus detection and treatment. The “HPV board: a future without papilloma virus” project was born, promoted by CNEL (Italian Council of Economics and Labor) with the collaboration of numerous scientific societies to commonly approach to public knowledge of HPV-related oral lesions and their clinical management. The preliminary results are related to the assessment of the proof-of-concept of this new project. More in details, “HPV Board” is a project that plans the presence of a working group, made up of otolaryngologists, dentists, oral and maxillofacial surgeons, in close contact with gynecologists, oncologists and pediatricians; this working group manages to combine very transversal skills, in order to promote primary prevention projects, early diagnosis and adequate therapies. The “HPV BOARD” project will give the opportunity to increase the attention of patients and doctors on the early diagnosis of oncological diseases dependent on infection by the infectious agent HPV. In this panorama, dentists will have the role of “first sentinel” of public health because oral health is an indicator, too often overlooked, for the prevention of numerous diseases. [ABSTRACT FROM AUTHOR]

Published
2022

18. IMPROVING ENDOSCOPIC ASSESSMENT AND MANAGEMENT OF LARGE NON-PEDUNCOLATED COLORECTAL LESIONS IN A WESTERN CENTER OVER 10 YEARS: LESSONS LEARNT AND IMPACT ON PATIENTS’ OUTCOMES

Author

Vanella, G, additional, Coluccio, C, additional, Antonelli, G, additional, Angeletti, S, additional, Micheli, F, additional, Barbato, A, additional, De Rossi, G, additional, Marchetti, A, additional, Mereu, E, additional, Pepe, P, additional, Corleto, VD, additional, D’Ambra, G, additional, Ruggeri, M, additional, and Di Giulio, E, additional

Published
2020
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28. Long-term results of the Italian Association of Pediatric Hematology and Oncology (AIEOP) Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia

Author

Conter V., Aricò M., Basso G., Biondi A., Barisone E., Messina C., Parasole R., De Rossi G., Locatelli F., Santoro N., Micalizzi C., Citterio M., Rizzari C., Silvestri D., Rondelli R., Lo Nigro L., Ziino O., Testi A.M., Masera G., Valsecchi M.G., Associazione Italiana di Ematologia ed Oncologia Pediatrica, PESSION, ANDREA, Conter V., Aricò M., Basso G., Biondi A., Barisone E., Messina C., Parasole R., De Rossi G., Locatelli F., Pession A., Santoro N., Micalizzi C., Citterio M., Rizzari C., Silvestri D., Rondelli R., Lo Nigro L., Ziino O., Testi AM., Masera G., Valsecchi MG., Associazione Italiana di Ematologia ed Oncologia Pediatrica., Conter, V, Aricò, M, Basso, G, Biondi, A, Barisone, E, Messina, C, Parasole, R, De Rossi, G, Locatelli, F, Pession, A, Santoro, N, Micalizzi, C, Citterio, M, Rizzari, C, Silvestri, D, Rondelli, R, Lo Nigro, L, Ziino, O, Testi, A, Masera, G, and Valsecchi, M

Subjects
Male, Oncology, Cancer Research, medicine.medical_specialty, Pediatrics, acute lymphoblastic leukemia, childhood, long-term results, Time Factors, Adolescent, Time Factor, Prognosi, Medical Oncology, Systemic therapy, Follow-Up Studie, Risk Factors, Internal medicine, Acute lymphocytic leukemia, Antineoplastic Combined Chemotherapy Protocols, medicine, Humans, Child, Survival rate, Childhood Acute Lymphoblastic Leukemia, Antineoplastic Combined Chemotherapy Protocol, Hematology, business.industry, Risk Factor, Remission Induction, Infant, Cancer, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, medicine.disease, Minimal residual disease, Survival Rate, Treatment Outcome, Italy, El Niño, Child, Preschool, Female, Cranial Irradiation, business, Follow-Up Studies, Human
Abstract

We analyzed the long-term outcome of 4865 patients treated in Studies 82, 87, 88, 91 and 95 for childhood acute lymphoblastic leukemia (ALL) of the Italian Association of Pediatric Hematology and Oncology (AIEOP). Treatment was characterized by progressive intensification of systemic therapy and reduction of cranial radiotherapy. A progressive improvement of results with reduction of isolated central nervous system relapse rate was obtained. Ten-year event-free survival increased from 53% in Study 82 to 72% in Study 95, whereas survival improved from 64 to 82%. Since 1991, all patients were treated according to Berlin-Frankfurt-Muenster (BFM) ALL treatment strategy. In Study 91, reduced treatment intensity (25%) yielded inferior results, but intensification of maintenance with high-dose (HD)-L-asparaginase (randomized) allowed to compensate for this disadvantage; in high-risk patients (HR, 15%), substitution of intensive polychemotherapy blocks for conventional BFM backbone failed to improve results. A marked improvement of results was obtained in HR patients when conventional BFM therapy was intensified with three polychemotherapy blocks and double delayed intensification (Study 95). The introduction of minimal residual disease monitoring and evaluation of common randomized questions by AIEOP and BFM groups in the protocol AIEOP-BFM-ALL 2000 are expected to further ameliorate treatment of children with ALL.

Published
2010

32. Pharmacokinetics of Daunorubicin and Daunorubicinol in infants with leukemia treated in the Interfant 99 Protocol

Author

Hempel, G, Relling, MV, de Rossi, G, Stary, J, De Lorenzo, P, VALSECCHI, MARIA GRAZIA, Barisone, E, Boos, J, Pieters, R., Pediatrics, Hempel, G, Relling, M, de Rossi, G, Stary, J, De Lorenzo, P, Valsecchi, M, Barisone, E, Boos, J, and Pieters, R

Subjects
Leukemia, Daunorubicin, Infant, Pharmacokinetic
Abstract

Background. There is an extreme paucity of pharmacokinetic data for anticancer agents in infants. Therefore, we aimed at characterizing the pharmacokinetics for daunorubicin in infants and examined their relationship to age, body weight, and body surface area. Procedure. Leukemia patients treated according to the Interfant 99 protocol received 30 mg/m2 daunorubicin, with dose reduction to 3/4 for patients 6-12 months old and 2/3 for patients

Published
2010

34. Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the 2 coagulation disorders

Author

Tagariello G, Iorio A, Santagostino E, Morfini M, Bisson R, Innocenti M, Mancuso ME, Mazzucconi MG, Pasta GL, Radossi P, Rodorigo G, Santoro C, Sartori R, Scaraggi A, Solimeno LP, Mannucci PM, Ciavarella N, Valdrè L, Targhetta R, Biasioli C, Vincenzi D, Molinari C, Boeri E, Mariani G, Lapecorella M, Coppola A, Schiavulli M, Rocino A, Mancuso G, Siragusa S, Malato A, Tagliaferri A, Rivolta F, Oliovecchio E, Marcucci M, Dragani A, Mancino A, D'Incà M, De Rossi G, Luciani M, Landolfi R, Piseddu G, Schinco PC, Rossetti G, Barillari G, Feola G, Gandini G, Giuffrida A, Castaman G., DI MINNO, GIOVANNI, Tagariello, G, Iorio, A, Santagostino, E, Morfini, M, Bisson, R, Innocenti, M, Mancuso, ME, Mazzucconi, MG, Pasta, GL, Radossi, P, Rodorigo, G, Santoro, C, Sartori, R, Scaraggi, A, Solimeno, LP, Mannucci, PM, Ciavarella, N, Valdrè, L, Targhetta, R, Biasioli, C, Vincenzi, D, Molinari, C, Boeri, E, Mariani, G, Lapecorella, M, di Minno, G, Coppola, A, Schiavulli, M, Rocino, A, Mancuso, G, Siragusa, S, Malato, A, Tagliaferri, A, Rivolta, F, Oliovecchio, E, Marcucci, M, Dragani, A, Mancino, A, D'Incà, M, De Rossi, G, Luciani, M, Landolfi, R, Piseddu, G, Schinco, PC, Rossetti, G, Barillari, G, Feola, G, Gandini, G, Giuffrida, A, Castaman, G, Mancuso, Me, Mazzucconi, Mg, Pasta, Gl, Solimeno, Lp, Mannucci, Pm, DI MINNO, Giovanni, Schinco, Pc, and Castaman, G.

Subjects
Adult, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Immunology, Population, macromolecular substances, Gene mutation, Hemophilia A, Hemophilia B, Severity of Illness Index, Biochemistry, Arthroplasty, Settore MED/15 - Malattie Del Sangue, Cohort Studies, Young Adult, Risk Factors, hemic and lymphatic diseases, Internal medicine, Severity of illness, medicine, Coagulopathy, Humans, Child, education, Retrospective Studies, education.field_of_study, Hematology, hamophilia, arthroplasty, business.industry, Retrospective cohort study, Cell Biology, Odds ratio, Blood Coagulation Disorders, Middle Aged, medicine.disease, Surgery, Italy, Joint Diseases, business, Algorithms
Abstract

Data from the Italian Hemophilia Centres were collected to perform a retrospective survey of joint arthroplasty in patients with severe hemophilia. Twenty-nine of 49 hemophilia centers reported that 328 of the 347 operations were carried out in 253 patients with severe hemophilia A (HA) and 19 in 15 patients with severe hemophilia B (HB). When results were normalized to the whole Italian hemophilia population (1770 severe HA and 319 severe HB), patients with HA had a 3-fold higher risk of undergoing joint arthroplasty (odds ratio [OR], 3.38; 95% confidence interval [CI], 1.97-5.77; P < .001). These results were confirmed after adjustment for age, HIV, hepatitis C virus (HCV), and inhibitor in a Cox regression model (HR, 2.65; 95% CI, 1.62-4.33; P < .001). The survival analysis of time to joint arthroplasty in the subset of patients with severe HA was not affected by the severity of factor VIII (FVIII) gene mutations. A systematic review of literature articles reporting joint arthroplasties in HA and HB showed that the proportion of HA patients who had undergone arthroplasties was higher than that of HB patients, in agreement with the findings in our Italian cohort. These data suggest that the 2 inherited coagulation disorders have a different severity of clinical phenotype.

Published
2009

35. Evidence-based recommendations on the treatment of von Willebrand disease in Italy

Author

Mannucci, Pm, Franchini, M, Castaman, G, Federici, Ab, Contino, L, Accorsi, A, Ciavarella, N, Schiavoni, M, Scaraggi, Fa, Rodorigo, G, Valdre, L, Targhetta, R, Tagariello, G, Radossi, P, Musso, R, Cultrera, D, Muleo, G, Iannacaro, P, Biasioli, C, Testa, S, Alatri, A, Vincenzi, D, Scapoli, G, Morfini, M, Molinari, Ac, Boeri, E, Caprino, D, Delios, G, Girotto, M, Mariani, G, Lapecorella, M, Carloni, Mt, Cantori, I, Santagostino, E, Gringeri, A, Marietta, M, Pedrazzoli, P, Di Minno, G, Coppola, A, Perricone, C, Schiavulli, M, Rocino, A, Berrettini, M, Zanon, E, Mancuso, G, Siragusa, S, Malato, A, Saccullo, G, Tagliaferri, A, Rivolta, F, Iorio, A, Oliovecchio, E, Ferrante, F, Dragani, A, Rossi, A, Mancino, A, Albertini, P, Macchi, S, D'Incà, M, De Rossi, G, Luciani, M, Landolfi, R, Mazzucconi, Maria Gabriella, Santoro, Cristina, Piseddu, G, Schinco, Pc, Rossetti, G, Barillari, G, Feola, G, Gandini, G., Mannucci, Pm, Franchini, M, Castaman, G, Federici, Ab, Contino, L, Accorsi, A, Ciavarella, N, Schiavoni, M, Scaraggi, Fa, Rodorigo, G, Valdre, L, Targhetta, R, Tagariello, G, Radossi, P, Musso, R, Cultrera, D, Muleo, G, Iannacaro, P, Biasioli, C, Testa, S, Alatri, A, Vincenzi, D, Scapoli, G, Morfini, M, Molinari, Ac, Boeri, E, Caprino, D, Delios, G, Girotto, M, Mariani, G, Lapecorella, M, Carloni, Mt, Cantori, I, Santagostino, E, Gringeri, A, Marietta, M, Pedrazzoli, P, DI MINNO, Giovanni, Coppola, A, Perricone, C, Schiavulli, M, Rocino, A, Berrettini, M, Zanon, E, Mancuso, G, Siragusa, S, Malato, A, Saccullo, G, Tagliaferri, A, Rivolta, F, Iorio, A, Oliovecchio, E, Ferrante, F, Dragani, A, Rossi, A, Mancino, A, Albertini, P, Macchi, S, D'Incà, M, De Rossi, G, Luciani, M, Landolfi, R, Mazzucconi, Mg, Santoro, C, Piseddu, G, Schinco, Pc, Rossetti, G, Barillari, G, Feola, G, and Gandini, G.

Subjects
Male, desmopressin, Evidence-Based Medicine, Factor VIII, Hemostatics, von willebrand disease, von Willebrand Diseases, von willebrand factor, Treatment Outcome, Italy, von Willebrand Factor, Humans, Deamino Arginine Vasopressin, Drug Therapy, Combination, Female, Original Article
Abstract

von Willebrand disease (VWD) is the most common hereditary bleeding disorder affecting both males and females. It arises from quantitative or qualitative defects of von Willebrand factor (VWF) and causes bleeding of mucous membranes and soft tissues. The aim of treatment is to correct the dual defect of haemostasis caused by the abnormal/reduced VWF and the concomitant deficiency of factor VIII (FVIII).This document contains evidence-based recommendations for the management of VWD compiled by AICE (the Italian Association of Haemophilia Centres). All the evidence supporting these recommendations are based on non-randomised comparative studies or case series, because randomised controlled clinical trials or meta-analyses are not available for this disease.Desmopressin (DDAVP) is the treatment of choice for patients with type 1 VWD with FVIII and VWF levels of 10 U/dL or more, while VWF/FVIII concentrates are indicated for those who are unresponsive or insufficiently responsive to DDAVP (severe type 1, type 2 and 3 VWD). VWF concentrates devoid of FVIII, not yet licensed in Italy, may be considered for short-term prophylaxis in elective surgery or for long-term secondary prophylaxis.

Published
2009

36. Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis

Author

IORIO A, OLIOVECCHIO E, MORFINI M, MANNUCCI PM, CONTINO L, ACCORSI A, CIAVARELLA N, SCHIAVONI M, SCARAGGI FA, RODORIGO G, VALDRÉ L, TARGHETTA R, TAGARIELLO G, RADOSSI P, MUSSO R, CULTRERA D, MULEO G, IANNACARO P, BIASIOLI C, TESTA S, ALATRI A, VINCENZI D, SCAPOLI G, MOLINARI AC, BOERI E, CAPRINO D, MARIANI G, LAPECORELLA M, CARLONI MT, CANTORI I, SANTAGOSTINO E, GRINGERI A, FEDERICI AB, MARIETTA M, PEDRAZZOLI P, DI MINNO G, PERRICONE C, SCHIAVULLI M, ROCINO A, BERRETTINI M, ZANON E, MANCUSO G, TAGLIAFERRI A, RIVOLTA F, FERRANTE F, DRAGANI A, ROSSI A, ALBERTINI P, MACCHI S, D'INCA M, DE ROSSI G, LUCIANI M, LANDOLFI R, MAZZUCCONI MG, SANTORO C, PISEDDU G, CARLA SCHINCO P, ROSSETTI G, BARILLARI G, FEOLA G, GANDINI G, FRANCHINI M, CASTAMAN G., COPPOLA, Antonino, SIRAGUSA, Sergio, MALATO, Alessandra, SACCULLO, Giorgia, MANCINO, Antonio, IORIO A, OLIOVECCHIO E, MORFINI M, MANNUCCI PM, CONTINO L, ACCORSI A, CIAVARELLA N, SCHIAVONI M, SCARAGGI FA, RODORIGO G, VALDRÉ L, TARGHETTA R, TAGARIELLO G, RADOSSI P, MUSSO R, CULTRERA D, MULEO G, IANNACARO P, BIASIOLI C, TESTA S, ALATRI A, VINCENZI D, SCAPOLI G, MOLINARI AC, BOERI E, CAPRINO D, MARIANI G, LAPECORELLA M, CARLONI MT, CANTORI I, SANTAGOSTINO E, GRINGERI A, FEDERICI AB, MARIETTA M, PEDRAZZOLI P, DI MINNO G, COPPOLA A, PERRICONE C, SCHIAVULLI M, ROCINO A, BERRETTINI M, ZANON E, MANCUSO G, SIRAGUSA S, MALATO A, SACCULLO G, TAGLIAFERRI A, RIVOLTA F, FERRANTE F, DRAGANI A, ROSSI A, MANCINO A, ALBERTINI P, MACCHI S, D'INCA M, DE ROSSI G, LUCIANI M, LANDOLFI R, MAZZUCCONI MG, SANTORO C, PISEDDU G, CARLA SCHINCO P, ROSSETTI G, BARILLARI G, FEOLA G, GANDINI G, FRANCHINI M, and CASTAMAN G

Subjects
methodology, haemophilia, Settore MED/15 - Malattie Del Sangue
Published
2008

37. LAL infant introduces a new specific genomic profile

Author

BARDINI, MICHELA, SPINELLI, ROBERTA, FAZIO, GRAZIA, BIONDI, ANDREA, Corral, L, Mangano, E, Cifola, I, Basso, G, De Rossi, G, Battaglia, C, Cazzaniga, G., Bardini, M, Spinelli, R, Corral, L, Mangano, E, Fazio, G, Cifola, I, Basso, G, De Rossi, G, Biondi, A, Battaglia, C, and Cazzaniga, G

Subjects
genomic profile, SNP array genotyping, LAL infant
Published
2008

38. Italian Registry of Haemophilia and Allied Disorders. Objectives, methodology and data analysis

Author

Iorio, A, Oliovecchio, E, Morfini, M, Mannucci, Pm, Contino, L, Accorsi, A, Ciavarella, N, Schiavoni, M, Scaraggi, Fa, Rodorigo, G, Valdré, L, Targhetta, R, Tagariello, G, Radossi, P, Musso, R, Cultrera, D, Muleo, G, Iannacaro, P, Biasioli, C, Testa, S, Alatri, A, Vincenzi, D, Scapoli, G, Molinari, Ac, Boeri, E, Caprino, D, Mariani, G, Lapecorella, M, Carloni, Mt, Cantori, I, Santagostino, E, Gringeri, A, Federici, Ab, Marietta, M, Pedrazzoli, P, Di Minno, G, Coppola, A, Perricone, C, Schiavulli, M, Rocino, A, Berrettini, M, Zanon, E, Mancuso, G, Siragusa, S, Malato, A, Saccullo, G, Tagliaferri, A, Rivolta, F, Ferrante, F, Dragani, A, Rossi, A, Mancino, A, Albertini, P, Macchi, S, Hassan, J, D'Inca, M, De Rossi, G, Luciani, M, Landolfi, R, Mazzucconi, Maria Gabriella, Santoro, Cristina, Piseddu, G, Carla Schinco, P, Rossetti, G, Barillari, G, Feola, G, Gandini, G, Franchini, M, Castaman, G., Iorio, A, Oliovecchio, E, Morfini, M, Mannucci, Pm, Contino, L, Accorsi, A, Ciavarella, N, Schiavoni, M, Scaraggi, Fa, Rodorigo, G, Valdré, L, Targhetta, R, Tagariello, G, Radossi, P, Musso, R, Cultrera, D, Muleo, G, Iannacaro, P, Biasioli, C, Testa, S, Alatri, A, Vincenzi, D, Scapoli, G, Molinari, Ac, Boeri, E, Caprino, D, Mariani, G, Lapecorella, M, Carloni, Mt, Cantori, I, Santagostino, E, Gringeri, A, Federici, Ab, Marietta, M, Pedrazzoli, P, DI MINNO, Giovanni, Coppola, A, Perricone, C, Schiavulli, M, Rocino, A, Berrettini, M, Zanon, E, Mancuso, G, Siragusa, S, Malato, A, Saccullo, G, Tagliaferri, A, Rivolta, F, Ferrante, F, Dragani, A, Rossi, A, Mancino, A, Albertini, P, Macchi, S, Hassan, J, D'Inca, M, De Rossi, G, Luciani, M, Landolfi, R, Mazzucconi, Mg, Santoro, C, Piseddu, G, Carla Schinco, P, Rossetti, G, Barillari, G, Feola, G, Gandini, G, Franchini, M, and Castaman, G.

Subjects
Adult, Male, Pediatrics, medicine.medical_specialty, Adolescent, Haemophilia A, MEDLINE, Haemophilia, Severity of Illness Index, haemophilia, registry, von willebrand's disease, von willebrand’s disease, Blood Coagulation Disorders, Inherited, Von willebrand, Severity of illness, Health care, Computer software, medicine, Humans, Haemophilia B, Registries, Age of Onset, Child, Genetics (clinical), Societies, Medical, Aged, business.industry, Infant, Hematology, General Medicine, Middle Aged, medicine.disease, Databases as Topic, Italy, Child, Preschool, Data Interpretation, Statistical, Female, Medical emergency, business
Abstract

National haemophilia registries are powerful instruments to support health care and research. A national registry was established in Italy by the Ministry of Health until 1999. Since 2003 the Italian Association of Haemophilia Centres (AICE) started a new programme aiming at building up the Italian Registry of Haemophilia and Allied Disorders. The AICE identified an expert panel to steer the registry. A computer software to assist patient management was developed and all the AICE-affiliated haemophilia treatment centres (HTC) were prompted to adopt it. Twice a year a predefined set of anonymized data is centralized and merged into a national database. Duplicated entries are managed through a confidentiality sparing mechanism. The database covers sociodemographic, clinical, laboratory and treatment data. A subset of data are shared with the Ministry of Health (Istituto Superiore di Sanita,ISS).Overall, data were collected six times by 43 of 49 HTC; 41 centres updated their patients' records up to December 2006. The database contains 6632 unique records, 442 of them referring to dead patients. Database growth and missing data clearance showed a constantly positive trend over time. The database has collected records of the following alive patients - haemophilia A: 1364 severe, 398 moderate and 935 mild; haemophilia B: 231 severe, 138 moderate and 204 mild; von Willebrand's disease: 1208 type 1, 346 type 2 and 96 type 3. Inhibitor patients were 296 (of which 194 high responders and 65 low responders).The Italian registry run by AICE adds to the list of the available national haemophilia registries and is intended to establish treatment guidelines and foster research projects in Italy.

Published
2008

39. Patterns of domestic migrations and access to childhood cancer care centres in Italy: A report from the hospital based registry of the Italian Association of Pediatric Hematology and Oncology (AIEOP)

Author

Dama, E, Rondelli, R, De Rosa, M, Aricò, M, Carli, M, Bellani, Ff, Magnani, C, Merletti, F, Pastore, G, Pession, A, Madon, E, Dini, G, Carnelli, V, Fedeli, F, Fossati Bellani, F, Masera, G, Locatelli, F, Cornelli, Pe, Notarangelo, L, Nespoli, L, Bagnulo, S, Marradi, P, Musi, L, Rodeghiero, F, Grotto, P, Rossetti, F, Battisti, L, Tamaro, Paolo, Mascarin, M, Nocerino, A, Izzi, G, Paolucci, P, Ambrosioni, G, Picci, P, Borgna Pignatti, C, Vecchi, V, Bernini, G, Morgese, G, Favre, C, Zucchetti, P, Pierani, P, Felici, L, Visani, G, Di Bartolomeo, P, Ballati, G, Castello, Ma, De Rossi, G, Donfrancesco, A, Foà, R, Menichelli, A, Riccardi, R, Di Tullio MT, Fiorillo, A, Poggi, V, Amendola, G, Ladogana, S, Ruggiero, L, Pozzi, S, De Mattia, D, Magro, S, Nobile, F, Sperlì, D, Schilirò, G, Gallisai, D, Biddau, P., Dama, E, Rondelli, R, De Rosa, M, Aricò, M, Carli, M, Bellani, Ff, Magnani, C, Merletti, F, Pastore, G, Pession, A, Madon, E, Dini, G, Carnelli, V, Fedeli, F, Fossati Bellani, F, Masera, G, Locatelli, F, Cornelli, Pe, Notarangelo, L, Nespoli, L, Bagnulo, S, Marradi, P, Musi, L, Rodeghiero, F, Grotto, P, Rossetti, F, Battisti, L, Tamaro, Paolo, Mascarin, M, Nocerino, A, Izzi, G, Paolucci, P, Ambrosioni, G, Picci, P, Borgna Pignatti, C, Vecchi, V, Bernini, G, Morgese, G, Favre, C, Zucchetti, P, Pierani, P, Felici, L, Visani, G, Di Bartolomeo, P, Ballati, G, Castello, Ma, De Rossi, G, Donfrancesco, A, Foà, R, Menichelli, A, Riccardi, R, Di Tullio, Mt, Fiorillo, A, Poggi, V, Amendola, G, Ladogana, S, Ruggiero, L, Pozzi, S, De Mattia, D, Magro, S, Nobile, F, Sperlì, D, Schilirò, G, Gallisai, D, Biddau, P., Dama E, Rondelli R, De Rosa M, Aricò M, Carli M, Bellani FF, Magnani C, Merletti F, Pastore G, Pession A, and Italian Association of Pediatric Hematology and Oncology (AIEOP).

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Adolescent, Paediatric haematology, care access, childhood cancer, italy, specialised cancer centres, Childhood cancer, Child Health Services, Regional Medical Programs, Tertiary care, Health Services Accessibility, domestic migration, Internal medicine, Neoplasms, Oncology Service, Hospital, medicine, Humans, Child, Specialised cancer centres, Care access, Italy, business.industry, Infant, Newborn, Infant, Hospital based, El Niño, Child, Preschool, Residence, Female, Health Services Research, Pediatric hematology, business, Delivery of Health Care
Abstract

Tertiary care centres, grouped in the Italian Association of Paediatric Haematology and Oncology (AIEOP) are unevenly distributed across the country. In an attempt to describe their perceived efficacy, we matched the residence and the location of the treatment centre in 18,441 patients aged ⩽15 years treated in the AIEOP network between 1989 and 2005. Overall, centres located in the central and southern regions were less appealing than those located in the North, although this trend decreased over the study period. Patients with solid tumours migrated more frequently than those with leukaemia or lymphoma. Information resulting from better knowledge of the non-random migrations for treatment of children with cancer will be useful to refine planning of the national paediatric haematology-oncology network with social and economic implications.

Published
2008

40. Survival of children with cancer in Italy, 1989-98. A report from the hospital based registry of the Italian Association of Pediatric Haematology and Oncology (AIEOP)

Author

Pession A, Dama E, Rondelli R, Magnani C, De Rosa M, Locatelli F, Fagioli F, Haupt R, Jankovic M, Terracini B, Merletti F, Pastore G, Italian Association of Paediatric Haematology, Oncology Madon E, Dini G, Carnelli V, Fedeli F, Fossati Bellani F, Masera G, Cornelli PE, Porta F, Dorizzi A, Nespoli A, Carli M, Marradi P, Rodeghiero F, Musi L, Mascarin M, Nocerino A, Izzi G, Paolucci P, Ambrosioni G, Picci P, Borgna Pignatti C, Bernini G, Morgese G, Favre C, Aversa F, Pierani P, Di Marzio A, Foà R, De Rossi G, Donfrancesco A, Castello MA, Casale F, Poggi V, Auricchio S, Antonelli P, Ladogana S, De Mattia D, Magro S, Nobile F, Aricò M, Schilirò G, Gallisai D, Argiolu F., TAMARO, PAOLO, Pession, A, Dama, E, Rondelli, R, Magnani, C, De Rosa, M, Locatelli, F, Fagioli, F, Haupt, R, Jankovic, M, Terracini, B, Merletti, F, Pastore, G, Italian Association of Paediatric, Haematology, Oncology Madon, E, Dini, G, Carnelli, V, Fedeli, F, Fossati Bellani, F, Masera, G, Cornelli, Pe, Porta, F, Dorizzi, A, Nespoli, A, Carli, M, Marradi, P, Rodeghiero, F, Musi, L, Tamaro, Paolo, Mascarin, M, Nocerino, A, Izzi, G, Paolucci, P, Ambrosioni, G, Picci, P, Borgna Pignatti, C, Bernini, G, Morgese, G, Favre, C, Aversa, F, Pierani, P, Di Marzio, A, Foà, R, De Rossi, G, Donfrancesco, A, Castello, Ma, Casale, F, Poggi, V, Auricchio, S, Antonelli, P, Ladogana, S, De Mattia, D, Magro, S, Nobile, F, Aricò, M, Schilirò, G, Gallisai, D, Argiolu, F., Pession A, Dama E, Rondelli R, Magnani C, De Rosa M, Locatelli F, Fagioli F, Haupt R, Jankovic M, Terracini B, Merletti F, Pastore G, and on behalf of the Italian Association of Paediatric Haematology and Oncology

Subjects
Oncology, Male, Cancer Research, medicine.medical_specialty, Pediatrics, Adolescent, Lymphoproliferative disorders, Cancer registration, survival, children cancer, Internal medicine, Neuroblastoma, Neoplasms, medicine, Humans, Survivors, Sex Distribution, Child, Survival rate, Childhood cancer, Gender, Italy, Survival, Hematology, business.industry, Hazard ratio, Cancer, Infant, medicine.disease, Lymphoma, El Niño, Child, Preschool, Female, business, Epidemiologic Methods
Abstract

We describe the survival patterns of 10,791 Italian children (age 0-14) diagnosed with cancer during 1989-1998 and who were included in the hospital-based registry of the Italian Association of Paediatric Haematology and Oncology. Five-year cumulative survival percentages were 76% for lymphoproliferative disorders and 68% for solid tumours. Survival rates in 1994-1998 significantly improved for acute lymphocytic leukaemia (ALL), acute non-lymphocytic leukaemia, Hodgkin's lymphoma and Wilms' tumour. Gender and age were determinants of survival for some specific types of cancer. Girls with ALL and neuroblastoma exhibited a significant advantage (hazard ratio HR 0.72, 0.62-0.83) and disadvantage (HR 0.73, 0.59-0.90) over boys, respectively. Children with a Wilms' tumour diagnosed above age 3 had a worse prognosis than younger children (HR 2.3, 1.4-4.1). The persisting gender-related difference in survival rate for ALL requires understanding as to whether it is attributable to delays in the adoption of more recent therapeutic protocols, while the corresponding findings for Wilms' tumour and neuroblastoma deserve further biological interpretation.

Published
2008

41. Risultati a lungo termine ottenuti nei bambini con leucemia linfoblastica acuta ( LLA) ad immunofenotipo T arruolati nei protocolli AIEOP LLA 91 e 95

Author

Rizzari C., Conter V., Valsecchi M.G., Aricò M., Barisone E., Basso G., Biondi A., Casale F., Citterio M., De Rossi G., Lo Nigro L., Locatelli F., Messina C., Micalizzi C., Parasole R., Rondelli R., Santoro N., Silvestri D., Testi A.M., Masera G., PESSION, ANDREA, Rizzari C., Conter V., Valsecchi MG., Aricò M., Barisone E., Basso G., Biondi A., Casale F., Citterio M., De Rossi G., Lo Nigro L., Locatelli F., Messina C., Micalizzi C., Parasole R., Pession A., Rondelli R., Santoro N., Silvestri D., Testi AM., and Masera G.

Published
2007

43. Risultati del protocollo AIEOP-LLA 95 per il trattamento della leucemia linfoblastica acuta(LLA) dell'età pediatrica

Author

Aricò M., Rizzari C., Valsecchi M.G., Barisone E., Basso G., Biondi A., Casale F., de rossi G., Locatelli F., Lo Nigro L., Messina C., Micalizzi C., parasole R., Rondelli R., Sntoro N., Silvestri S., Testi A.M., Masera G., Conter V., PESSION, ANDREA, Aricò M., Rizzari C., Valsecchi MG., Barisone E., Basso G., Biondi A., Casale F., de rossi G., Locatelli F., Lo Nigro L., Messina C., Micalizzi C., parasole R., Pession A., Rondelli R., Sntoro N., Silvestri S., Testi AM., Masera G., and Conter V.

Published
2006

44. Incidenza ed impatto prognostico dei trascritti chimerici MLL-ENL e CALM-AF10 nei bambini affetti da leucemia linfoblastica acuta T-lineage ( LLA -T)arruolati nel protocollo AIEOP -LLA 2000:incidenza ed impattosulla prognosi

Author

Lo Nigro L., Caserta C., Mirabile E., Rossi V., Silvestri D., Spinelli M., Cazzaniga G., Rizzari C., Aricò M., Barisone E., Basso G., Biondi A., Casale F., De Rossi G., Locatelli F., Messina C., Micalizzi C., Santoro N., Testi A.M., Valsecchi M.G., Masera G., Conter V., PESSION, ANDREA, Lo Nigro L., Caserta C., Mirabile E., Rossi V., Silvestri D., Spinelli M., Cazzaniga G., Rizzari C., Aricò M., Barisone E., Basso G., Biondi A., Casale F., De Rossi G., Locatelli F., Messina C., Micalizzi C., Pession A., Santoro N., Testi AM., Valsecchi MG., Masera G., and Conter V.

Published
2006

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