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2. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study

Author

Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo-Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Cameron, Peter, Lozano, Guillermo Carbayo, Carbonara, Marco, Castaño-León, Ana M., Cavallo, Simona, Chevallard, Giorgio, Chieregato, Arturo, Citerio, Giuseppe, Clusmann, Hans, Coburn, Mark Steven, Coles, Jonathan, Cooper, Jamie D., Correia, Marta, Čović, Amra, Curry, Nicola, Czeiter, Endre, Czosnyka, Marek, Dahyot-Fizelier, Claire, Dark, Paul, Dawes, Helen, De Keyser, Véronique, Degos, Vincent, Della Corte, Francesco, Boogert, Hugo den, Depreitere, Bart, Đilvesi, Đula, Dixit, Abhishek, Donoghue, Emma, Dreier, Jens, Dulière, Guy-Loup, Ercole, Ari, Esser, Patrick, Ezer, Erzsébet, Fabricius, Martin, Feigin, Valery L., Foks, Kelly, Frisvold, Shirin, Furmanov, Alex, Gagliardo, Pablo, Galanaud, Damien, Gantner, Dashiell, Gao, Guoyi, George, Pradeep, Ghuysen, Alexandre, Giga, Lelde, Glocker, Ben, Golubović, Jagoš, Gomez, Pedro A., Gratz, Johannes, Gravesteijn, Benjamin, Grossi, Francesca, Gruen, Russell L., Gupta, Deepak, Haagsma, Juanita A., Haitsma, Iain, Helbok, Raimund, Helseth, Eirik, Horton, Lindsay, Huijben, Jilske, Hutchinson, Peter J., Jacobs, Bram, Jankowski, Stefan, Jarrett, Mike, Jiang, Ji-yao, Johnson, Faye, Jones, Kelly, Karan, Mladen, Kolias, Angelos G., Kompanje, Erwin, Kondziella, Daniel, Kornaropoulos, Evgenios, Koskinen, Lars-Owe, Kovács, Noémi, Lagares, Alfonso, Lanyon, Linda, Laureys, Steven, Lecky, Fiona, Ledoux, Didier, Lefering, Rolf, Legrand, Valerie, Lejeune, Aurelie, Levi, Leon, Lightfoot, Roger, Lingsma, Hester, Maas, Andrew I.R., Maegele, Marc, Majdan, Marek, Manara, Alex, Manley, Geoffrey, Maréchal, Hugues, Martino, Costanza, Mattern, Julia, McMahon, Catherine, Melegh, Béla, Menon, David, Menovsky, Tomas, Mikolic, Ana, Misset, Benoit, Muraleedharan, Visakh, Murray, Lynnette, Nair, Nandesh, Negru, Ancuta, Nelson, David, Newcombe, Virginia, Nieboer, Daan, Nyirádi, József, Oresic, Matej, Ortolano, Fabrizio, Otesile, Olubukola, Palotie, Aarno, Parizel, Paul M., Payen, Jean-François, Perera, Natascha, Perlbarg, Vincent, Persona, Paolo, Peul, Wilco, Piippo-Karjalainen, Anna, Pirinen, Matti, Pisica, Dana, Ples, Horia, Polinder, Suzanne, Pomposo, Inigo, Posti, Jussi P., Puybasset, Louis, Rădoi, Andreea, Ragauskas, Arminas, Raj, Rahul, Rambadagalla, Malinka, Rehorčíková, Veronika, Helmrich, Isabel Retel, Rhodes, Jonathan, Richardson, Sylvia, Richter, Sophie, Ripatti, Samuli, Rocka, Saulius, Roe, Cecilie, Roise, Olav, Rosand, Jonathan, Rosenfeld, Jeffrey, Rosenlund, Christina, Rosenthal, Guy, Rossaint, Rolf, Rossi, Sandra, Rueckert, Daniel, Rusnák, Martin, Sahuquillo, Juan, Sakowitz, Oliver, Sanchez-Porras, Renan, Sandor, Janos, Schäfer, Nadine, Schmidt, Silke, Schoechl, Herbert, Schoonman, Guus, Schou, Rico Frederik, Schwendenwein, Elisabeth, Sewalt, Charlie, Skandsen, Toril, Smielewski, Peter, Sorinola, Abayomi, Stamatakis, Emmanuel, Stanworth, Simon, Kowark, Ana, Stevens, Robert, Stewart, William, Steyerberg, Ewout W., Stocchetti, Nino, Sundström, Nina, Takala, Riikka, Tamás, Viktória, Tamosuitis, Tomas, Taylor, Mark Steven, Ao, Braden Te, Tenovuo, Olli, Theadom, Alice, Thomas, Matt, Tibboel, Dick, Timmers, Marjolijn, Tolias, Christos, Trapani, Tony, Tudora, Cristina Maria, Unterberg, Andreas, Vajkoczy, Peter, Valeinis, Egils, Vallance, Shirley, Vámos, Zoltán, Van der Jagt, Mathieu, van der Naalt, Joukje, Van der Steen, Gregory, van Dijck, Jeroen T.J.M., van Essen, Thomas A., Van Hecke, Wim, van Heugten, Caroline, Van Praag, Dominique, Van Veen, Ernest, van Wijk, Roel, Vyvere, Thijs Vande, Vargiolu, Alessia, Vega, Emmanuel, Velt, Kimberley, Verheyden, Jan, Vespa, Paul M., Vik, Anne, Vilcinis, Rimantas, Volovici, Victor, von Steinbüchel, Nicole, Voormolen, Daphne, Vulekovic, Petar, Wang, Kevin K.W., Wiegers, Eveline, Williams, Guy, Wilson, Lindsay, Winzeck, Stefan, Wolf, Stefan, Yang, Zhihui, Ylén, Peter, Younsi, Alexander, Zeiler, Frederick A., Ziverte, Agate, Zoerle, Tommaso, van Erp, Inge A.M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J.A., Manley, Geoffrey T., de Ruiter, Godard C.W., and Peul, Wilco C.

Published
2023
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8. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI): an observational cohort study

Author

van Essen, Thomas A., primary, van Erp, Inge A.M., additional, Lingsma, Hester F., additional, Pisică, Dana, additional, Yue, John K., additional, Singh, Ranjit D., additional, van Dijck, Jeroen T.J.M., additional, Volovici, Victor, additional, Younsi, Alexander, additional, Kolias, Angelos, additional, Peppel, Lianne D., additional, Heijenbrok-Kal, Majanka, additional, Ribbers, Gerard M., additional, Menon, David K., additional, Hutchinson, Peter J.A., additional, Manley, Geoffrey T., additional, Depreitere, Bart, additional, Steyerberg, Ewout W., additional, Maas, Andrew I.R., additional, de Ruiter, Godard C.W., additional, Peul, Wilco C., additional, Åkerlund, Cecilia, additional, Amrein, Krisztina, additional, Andelic, Nada, additional, Andreassen, Lasse, additional, Anke, Audny, additional, Antoni, Anna, additional, Audibert, Gérard, additional, Azouvi, Philippe, additional, Azzolini, Maria Luisa, additional, Bartels, Ronald, additional, Barzó, Pál, additional, Beauvais, Romuald, additional, Beer, Ronny, additional, Bellander, Bo-Michael, additional, Belli, Antonio, additional, Benali, Habib, additional, Berardino, Maurizio, additional, Beretta, Luigi, additional, Blaabjerg, Morten, additional, Bragge, Peter, additional, Brazinova, Alexandra, additional, Brinck, Vibeke, additional, Brooker, Joanne, additional, Brorsson, Camilla, additional, Buki, Andras, additional, Bullinger, Monika, additional, Cabeleira, Manuel, additional, Caccioppola, Alessio, additional, Calappi, Emiliana, additional, Calvi, Maria Rosa, additional, Cameron, Peter, additional, Lozano, Guillermo Carbayo, additional, Carbonara, Marco, additional, Castaño-León, Ana M., additional, Cavallo, Simona, additional, Chevallard, Giorgio, additional, Chieregato, Arturo, additional, Citerio, Giuseppe, additional, Clusmann, Hans, additional, Coburn, Mark Steven, additional, Coles, Jonathan, additional, Cooper, Jamie D., additional, Correia, Marta, additional, Čović, Amra, additional, Curry, Nicola, additional, Czeiter, Endre, additional, Czosnyka, Marek, additional, Dahyot-Fizelier, Claire, additional, Dark, Paul, additional, Dawes, Helen, additional, De Keyser, Véronique, additional, Degos, Vincent, additional, Della Corte, Francesco, additional, Boogert, Hugo den, additional, Đilvesi, Đula, additional, Dixit, Abhishek, additional, Donoghue, Emma, additional, Dreier, Jens, additional, Dulière, Guy-Loup, additional, Ercole, Ari, additional, Esser, Patrick, additional, Ezer, Erzsébet, additional, Fabricius, Martin, additional, Feigin, Valery L., additional, Foks, Kelly, additional, Frisvold, Shirin, additional, Furmanov, Alex, additional, Gagliardo, Pablo, additional, Galanaud, Damien, additional, Gantner, Dashiell, additional, Gao, Guoyi, additional, George, Pradeep, additional, Ghuysen, Alexandre, additional, Giga, Lelde, additional, Glocker, Ben, additional, Golubović, Jagoš, additional, Gomez, Pedro A., additional, Gratz, Johannes, additional, Gravesteijn, Benjamin, additional, Grossi, Francesca, additional, Gruen, Russell L., additional, Gupta, Deepak, additional, Haagsma, Juanita A., additional, Haitsma, Iain, additional, Helbok, Raimund, additional, Helseth, Eirik, additional, Horton, Lindsay, additional, Huijben, Jilske, additional, Hutchinson, Peter J., additional, Jacobs, Bram, additional, Jankowski, Stefan, additional, Jarrett, Mike, additional, Jiang, Ji-yao, additional, Johnson, Faye, additional, Jones, Kelly, additional, Karan, Mladen, additional, Kolias, Angelos G., additional, Kompanje, Erwin, additional, Kondziella, Daniel, additional, Kornaropoulos, Evgenios, additional, Koskinen, Lars-Owe, additional, Kovács, Noémi, additional, Lagares, Alfonso, additional, Lanyon, Linda, additional, Laureys, Steven, additional, Lecky, Fiona, additional, Ledoux, Didier, additional, Lefering, Rolf, additional, Legrand, Valerie, additional, Lejeune, Aurelie, additional, Levi, Leon, additional, Lightfoot, Roger, additional, Lingsma, Hester, additional, Maegele, Marc, additional, Majdan, Marek, additional, Manara, Alex, additional, Manley, Geoffrey, additional, Maréchal, Hugues, additional, Martino, Costanza, additional, Mattern, Julia, additional, McMahon, Catherine, additional, Melegh, Béla, additional, Menon, David, additional, Menovsky, Tomas, additional, Mikolic, Ana, additional, Misset, Benoit, additional, Muraleedharan, Visakh, additional, Murray, Lynnette, additional, Nair, Nandesh, additional, Negru, Ancuta, additional, Nelson, David, additional, Newcombe, Virginia, additional, Nieboer, Daan, additional, Nyirádi, József, additional, Oresic, Matej, additional, Ortolano, Fabrizio, additional, Otesile, Olubukola, additional, Palotie, Aarno, additional, Parizel, Paul M., additional, Payen, Jean-François, additional, Perera, Natascha, additional, Perlbarg, Vincent, additional, Persona, Paolo, additional, Peul, Wilco, additional, Piippo-Karjalainen, Anna, additional, Pirinen, Matti, additional, Pisica, Dana, additional, Ples, Horia, additional, Polinder, Suzanne, additional, Pomposo, Inigo, additional, Posti, Jussi P., additional, Puybasset, Louis, additional, Rădoi, Andreea, additional, Ragauskas, Arminas, additional, Raj, Rahul, additional, Rambadagalla, Malinka, additional, Rehorčíková, Veronika, additional, Helmrich, Isabel Retel, additional, Rhodes, Jonathan, additional, Richardson, Sylvia, additional, Richter, Sophie, additional, Ripatti, Samuli, additional, Rocka, Saulius, additional, Roe, Cecilie, additional, Roise, Olav, additional, Rosand, Jonathan, additional, Rosenfeld, Jeffrey, additional, Rosenlund, Christina, additional, Rosenthal, Guy, additional, Rossaint, Rolf, additional, Rossi, Sandra, additional, Rueckert, Daniel, additional, Rusnák, Martin, additional, Sahuquillo, Juan, additional, Sakowitz, Oliver, additional, Sanchez-Porras, Renan, additional, Sandor, Janos, additional, Schäfer, Nadine, additional, Schmidt, Silke, additional, Schoechl, Herbert, additional, Schoonman, Guus, additional, Schou, Rico Frederik, additional, Schwendenwein, Elisabeth, additional, Sewalt, Charlie, additional, Skandsen, Toril, additional, Smielewski, Peter, additional, Sorinola, Abayomi, additional, Stamatakis, Emmanuel, additional, Stanworth, Simon, additional, Kowark, Ana, additional, Stevens, Robert, additional, Stewart, William, additional, Stocchetti, Nino, additional, Sundström, Nina, additional, Takala, Riikka, additional, Tamás, Viktória, additional, Tamosuitis, Tomas, additional, Taylor, Mark Steven, additional, Ao, Braden Te, additional, Tenovuo, Olli, additional, Theadom, Alice, additional, Thomas, Matt, additional, Tibboel, Dick, additional, Timmers, Marjolijn, additional, Tolias, Christos, additional, Trapani, Tony, additional, Tudora, Cristina Maria, additional, Unterberg, Andreas, additional, Vajkoczy, Peter, additional, Valeinis, Egils, additional, Vallance, Shirley, additional, Vámos, Zoltán, additional, Van der Jagt, Mathieu, additional, van der Naalt, Joukje, additional, Van der Steen, Gregory, additional, van Essen, Thomas A., additional, Van Hecke, Wim, additional, van Heugten, Caroline, additional, Van Praag, Dominique, additional, Van Veen, Ernest, additional, van Wijk, Roel, additional, Vyvere, Thijs Vande, additional, Vargiolu, Alessia, additional, Vega, Emmanuel, additional, Velt, Kimberley, additional, Verheyden, Jan, additional, Vespa, Paul M., additional, Vik, Anne, additional, Vilcinis, Rimantas, additional, von Steinbüchel, Nicole, additional, Voormolen, Daphne, additional, Vulekovic, Petar, additional, Wang, Kevin K.W., additional, Wiegers, Eveline, additional, Williams, Guy, additional, Wilson, Lindsay, additional, Winzeck, Stefan, additional, Wolf, Stefan, additional, Yang, Zhihui, additional, Ylén, Peter, additional, Zeiler, Frederick A., additional, Ziverte, Agate, additional, and Zoerle, Tommaso, additional

Published
2023
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10. Sonographic normal values for the cross-sectional area of the ulnar nerve: a systematic review and meta-analysis

Author

Zorgeenheid Plastische Chirurgie Medisch, Neurologen, Brain, Boers, Nadine, Martin, Enrico, Mazur, Marc, Krijgh, David D., Vlak, Monique H.M., de Ruiter, Godard C.W., Goedee, H. Stephan, Coert, J. Henk, Zorgeenheid Plastische Chirurgie Medisch, Neurologen, Brain, Boers, Nadine, Martin, Enrico, Mazur, Marc, Krijgh, David D., Vlak, Monique H.M., de Ruiter, Godard C.W., Goedee, H. Stephan, and Coert, J. Henk

Published
2023

11. Early surgery versus conservative treatment in patients with traumatic intracerebral hematoma:a CENTER-TBI study

Author

van Erp, Inge A.M., van Essen, Thomas A., Lingsma, Hester, Pisica, Dana, Singh, Ranjit D., van Dijck, Jeroen T.J.M., Volovici, Victor, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter, Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., Peul, Wilco C., van Erp, Inge A.M., van Essen, Thomas A., Lingsma, Hester, Pisica, Dana, Singh, Ranjit D., van Dijck, Jeroen T.J.M., Volovici, Victor, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter, Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., and Peul, Wilco C.

Abstract

Purpose: Evidence regarding the effect of surgery in traumatic intracerebral hematoma (t-ICH) is limited and relies on the STITCH(Trauma) trial. This study is aimed at comparing the effectiveness of early surgery to conservative treatment in patients with a t-ICH. Methods: In a prospective cohort, we included patients with a large t-ICH (< 48 h of injury). Primary outcome was the Glasgow Outcome Scale Extended (GOSE) at 6 months, analyzed with multivariable proportional odds logistic regression. Subgroups included injury severity and isolated vs. non-isolated t-ICH. Results: A total of 367 patients with a large t-ICH were included, of whom 160 received early surgery and 207 received conservative treatment. Patients receiving early surgery were younger (median age 54 vs. 58 years) and more severely injured (median Glasgow Coma Scale 7 vs. 10) compared to those treated conservatively. In the overall cohort, early surgery was not associated with better functional outcome (adjusted odds ratio (AOR) 1.1, (95% CI, 0.6–1.7)) compared to conservative treatment. Early surgery was associated with better outcome for patients with moderate TBI and isolated t-ICH (AOR 1.5 (95% CI, 1.1–2.0); P value for interaction 0.71, and AOR 1.8 (95% CI, 1.3–2.5); P value for interaction 0.004). Conversely, in mild TBI and those with a smaller t-ICH (< 33 cc), conservative treatment was associated with better outcome (AOR 0.6 (95% CI, 0.4–0.9); P value for interaction 0.71, and AOR 0.8 (95% CI, 0.5–1.0); P value for interaction 0.32). Conclusions: Early surgery in t-ICH might benefit those with moderate TBI and isolated t-ICH, comparable with results of the STITCH(Trauma) trial.

Published
2023

12. Comparative effectiveness of decompressive craniectomy versus craniotomy for traumatic acute subdural hematoma (CENTER-TBI):an observational cohort study

Author

van Essen, Thomas A., van Erp, Inge A.M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., van Dijck, Jeroen T.J.M., Volovici, Victor, Younsi, Alexander, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J.A., Manley, Geoffrey T., Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., Peul, Wilco C., van Essen, Thomas A., van Erp, Inge A.M., Lingsma, Hester F., Pisică, Dana, Yue, John K., Singh, Ranjit D., van Dijck, Jeroen T.J.M., Volovici, Victor, Younsi, Alexander, Kolias, Angelos, Peppel, Lianne D., Heijenbrok-Kal, Majanka, Ribbers, Gerard M., Menon, David K., Hutchinson, Peter J.A., Manley, Geoffrey T., Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., and Peul, Wilco C.

Abstract

Background: Limited evidence existed on the comparative effectiveness of decompressive craniectomy (DC) versus craniotomy for evacuation of traumatic acute subdural hematoma (ASDH) until the recently published randomised clinical trial RESCUE-ASDH. In this study, that ran concurrently, we aimed to determine current practice patterns and compare outcomes of primary DC versus craniotomy. Methods: We conducted an analysis of centre treatment preference within the prospective, multicentre, observational Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (known as CENTER-TBI) and NeuroTraumatology Quality Registry (known as Net-QuRe) studies, which enrolled patients throughout Europe and Israel (2014–2020). We included patients with an ASDH who underwent acute neurosurgical evacuation. Patients with severe pre-existing neurological disorders were excluded. In an instrumental variable analysis, we compared outcomes between centres according to treatment preference, measured by the case-mix adjusted proportion DC per centre. The primary outcome was functional outcome rated by the 6-months Glasgow Outcome Scale Extended, estimated with ordinal regression as a common odds ratio (OR), adjusted for prespecified confounders. Variation in centre preference was quantified with the median odds ratio (MOR). CENTER-TBI is registered with ClinicalTrials.gov, number NCT02210221, and the Resource Identification Portal (Research Resource Identifier SCR_015582). Findings: Between December 19, 2014 and December 17, 2017, 4559 patients with traumatic brain injury were enrolled in CENTER-TBI of whom 336 (7%) underwent acute surgery for ASDH evacuation; 91 (27%) underwent DC and 245 (63%) craniotomy. The proportion primary DC within total acute surgery cases ranged from 6 to 67% with an interquartile range (IQR) of 12–26% among 46 centres; the odds of receiving a DC for prognostically similar patients

Published
2023

18. A delphi procedure on rehabilitation outcome for patients with moderate to severe traumatic brain injury; first phase of the Neurotraumatology Quality Registry (NET-QURE)

Author

Peppel, Lianne D., Heijenbrok-Kal, Majanka H., Van Essen, Thomas A., De Ruiter, Godard C.W., Peul, Wilco C., Ribbers, Gerard M., Peppel, Lianne D., Heijenbrok-Kal, Majanka H., Van Essen, Thomas A., De Ruiter, Godard C.W., Peul, Wilco C., and Ribbers, Gerard M.

Abstract

Objective: To select a set of rehabilitation outcome instruments for a national Neurotrauma Quality Registry (Net-QuRe) among professionals involved in the care of patients with traumatic brain injury. Design: A 3-round online Delphi procedure. Subjects: Eighty professionals from multiple disciplines working in 1 of the 8 participating rehabilitation centres were invited to participate. The response rate varied from 70% to 76% per round. Methods: For the Delphi procedure, multiple outcome categories were defined based on the International Classification of Functioning, Disability and Health (ICF) with concomitant measurement instruments. For each category we strived for consensus on one instrument of at least 75%. Results: After the first round, consensus was reached for the category subjective cognitive functioning. After the second round for quality of life, pain, general functioning, anxiety and depression, general psychological functioning, communication (impairment), and personal factors. Finally, after the third round, consensus was reached for activities of daily living, participation, self-awareness, and aphasia. No consensus was reached for the categories motor function, cognitive function, comorbidity, fatigue, and employment status. Conclusion: Consensus was reached in 12 out of 17 outcome categories. A Delphi procedure seems to be a feasible method to collectively select measurement instruments for a multicentre study.

Published
2022

19. Surgery versus conservative treatment for traumatic acute subdural haematoma:a prospective, multicentre, observational, comparative effectiveness study

Author

van Essen, Thomas A., Lingsma, Hester F., Pisică, Dana, Singh, Ranjit D., Volovici, Victor, den Boogert, Hugo F., Younsi, Alexander, Peppel, Lianne D., Heijenbrok-Kal, Majanka H., Ribbers, Gerard M., Walchenbach, Robert, Menon, David K., Hutchinson, Peter, Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., Peul, Wilco C., Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Fabricius, Martin, Kondziella, Daniel, van Essen, Thomas A., Lingsma, Hester F., Pisică, Dana, Singh, Ranjit D., Volovici, Victor, den Boogert, Hugo F., Younsi, Alexander, Peppel, Lianne D., Heijenbrok-Kal, Majanka H., Ribbers, Gerard M., Walchenbach, Robert, Menon, David K., Hutchinson, Peter, Depreitere, Bart, Steyerberg, Ewout W., Maas, Andrew I.R., de Ruiter, Godard C.W., Peul, Wilco C., Åkerlund, Cecilia, Amrein, Krisztina, Andelic, Nada, Andreassen, Lasse, Anke, Audny, Antoni, Anna, Audibert, Gérard, Azouvi, Philippe, Azzolini, Maria Luisa, Bartels, Ronald, Barzó, Pál, Beauvais, Romuald, Beer, Ronny, Bellander, Bo Michael, Belli, Antonio, Benali, Habib, Berardino, Maurizio, Beretta, Luigi, Blaabjerg, Morten, Bragge, Peter, Brazinova, Alexandra, Brinck, Vibeke, Brooker, Joanne, Brorsson, Camilla, Buki, Andras, Bullinger, Monika, Cabeleira, Manuel, Caccioppola, Alessio, Calappi, Emiliana, Calvi, Maria Rosa, Fabricius, Martin, and Kondziella, Daniel

Abstract

Background: Despite being well established, acute surgery in traumatic acute subdural haematoma is based on low-grade evidence. We aimed to compare the effectiveness of a strategy preferring acute surgical evacuation with one preferring initial conservative treatment in acute subdural haematoma. Methods: We did a prospective, observational, comparative effectiveness study using data from participants enrolled in the Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) cohort. We included patients with no pre-existing severe neurological disorders who presented with acute subdural haematoma within 24 h of traumatic brain injury. Using an instrumental variable analysis, we compared outcomes between centres according to treatment preference for acute subdural haematoma (acute surgical evacuation or initial conservative treatment), measured by the case-mix-adjusted percentage of acute surgery per centre. The primary endpoint was functional outcome at 6 months as rated with the Glasgow Outcome Scale Extended, which was estimated with ordinal regression as a common odds ratio (OR) and adjusted for prespecified confounders. Variation in centre preference was quantified with the median OR (MOR). CENTER-TBI is registered with ClinicalTrials.gov, number NCT02210221, and the Resource Identification Portal (Research Resource Identifier SCR_015582). Findings: Between Dec 19, 2014 and Dec 17, 2017, 4559 patients with traumatic brain injury were enrolled in CENTER-TBI, of whom 1407 (31%) presented with acute subdural haematoma and were included in our study. Acute surgical evacuation was done in 336 (24%) patients, by craniotomy in 245 (73%) of those patients and by decompressive craniectomy in 91 (27%). Delayed decompressive craniectomy or craniotomy after initial conservative treatment (n=982) occurred in 107 (11%) patients. The percentage of patients who underwent acute surgery ranged from 5·6% to 51·5% (IQR 12·3–35·9) between cent

Published
2022

20. Randomized Evaluation of Surgery in Elderly with Traumatic Acute SubDural Hematoma (RESET-ASDH trial):study protocol for a pragmatic randomized controlled trial with multicenter parallel group design

Author

Singh, Ranjit D., van Dijck, Jeroen T.J.M., van Essen, Thomas A., Lingsma, Hester F., Polinder, Suzanne S., Kompanje, Erwin J.O., van Zwet, Erik W., Steyerberg, Ewout W., de Ruiter, Godard C.W., Depreitere, Bart, Peul, Wilco C., Singh, Ranjit D., van Dijck, Jeroen T.J.M., van Essen, Thomas A., Lingsma, Hester F., Polinder, Suzanne S., Kompanje, Erwin J.O., van Zwet, Erik W., Steyerberg, Ewout W., de Ruiter, Godard C.W., Depreitere, Bart, and Peul, Wilco C.

Abstract

Background: The rapidly increasing number of elderly (≥ 65 years old) with TBI is accompanied by substantial medical and economic consequences. An ASDH is the most common injury in elderly with TBI and the surgical versus conservative treatment of this patient group remains an important clinical dilemma. Current BTF guidelines are not based on high-quality evidence and compliance is low, allowing for large international treatment variation. The RESET-ASDH trial is an international multicenter RCT on the (cost-)effectiveness of early neurosurgical hematoma evacuation versus initial conservative treatment in elderly with a t-ASDH Methods: In total, 300 patients will be recruited from 17 Belgian and Dutch trauma centers. Patients ≥ 65 years with at first presentation a GCS ≥ 9 and a t-ASDH > 10 mm or a t-ASDH < 10 mm and a midline shift > 5 mm, or a GCS < 9 with a traumatic ASDH < 10 mm and a midline shift < 5 mm without extracranial explanation for the comatose state, for whom clinical equipoise exists will be randomized to early surgical hematoma evacuation or initial conservative management with the possibility of delayed secondary surgery. When possible, patients or their legal representatives will be asked for consent before inclusion. When obtaining patient or proxy consent is impossible within the therapeutic time window, patients are enrolled using the deferred consent procedure. Medical-ethical approval was obtained in the Netherlands and Belgium. The choice of neurosurgical techniques will be left to the discretion of the neurosurgeon. Patients will be analyzed according to an intention-to-treat design. The primary endpoint will be functional outcome on the GOS-E after 1 year. Patient recruitment starts in 2022 with the exact timing depending on the current COVID-19 crisis and is expected to end in 2024. Discussion: The study results will be implemented after publication and presented on international conferences. Depending on the trial r

Published
2022

23. Biomarkers for Traumatic Brain Injury: Data Standards and Statistical Considerations

Author

Huie, J. Russell, primary, Mondello, Stefania, additional, Lindsell, Christopher J., additional, Antiga, Luca, additional, Yuh, Esther L., additional, Zanier, Elisa R., additional, Masson, Serge, additional, Rosario, Bedda L., additional, Ferguson, Adam R., additional, Adeoye, Opeolu, additional, Badjatia, Neeraj, additional, Boase, Kim, additional, Bodien, Yelena, additional, Bullock, M. Ross, additional, Chesnut, Randall, additional, Corrigan, John D., additional, Crawford, Karen, additional, Diaz-Arrastia, Ramon, additional, Dikmen, Sureyya, additional, Duhaime, Ann-Christine, additional, Ellenbogen, Richard, additional, Feeser, V. Ramana, additional, Foreman, Brandon, additional, Gardner, Raquel, additional, Gaudette, Etienne, additional, Giacino, Joseph, additional, Goldman, Dana, additional, Gonzalez, Luis, additional, Gopinath, Shankar, additional, Gullapalli, Rao, additional, Hemphill, J. Claude, additional, Hotz, Gillian, additional, Jain, Sonia, additional, Korley, Frederick, additional, Kramer, Joel, additional, Kreitzer, Natalie, additional, Levin, Harvey, additional, Machamer, Joan, additional, Madden, Christopher, additional, Manley, Geoffrey T., additional, Martin, Alastair, additional, McAllister, Thomas, additional, McCrea, Michael, additional, Merchant, Randall, additional, Mukherjee, Pratik, additional, Nelson, Lindsay, additional, Ngwenya, Laura B., additional, Noel, Florence, additional, Okonkwo, David, additional, Perl, Daniel, additional, Puccio, Ava, additional, Rabinowitz, Miri, additional, Robertson, Claudia, additional, Rosand, Jonathan, additional, Sander, Angelle, additional, Schnyer, David, additional, Seabury, Seth, additional, Stein, Murray, additional, Taylor, Sabrina, additional, Temkin, Nancy, additional, Toga, Arthur, additional, Valadka, Alex, additional, Vassar, Mary, additional, Vespa, Paul, additional, Wang, Kevin, additional, Yue, John K., additional, Zafonte, Ross, additional, Ackerlund, Cecilia, additional, Adams, Hadie, additional, Agnoletti, Vanni, additional, Allanson, Judith, additional, Amrein, Krisztina, additional, Andaluz, Norberto, additional, Andelic, Nada, additional, Andreassen, Lasse, additional, Anke, Audny, additional, Antun, Azasevac, additional, Antoni, Anna, additional, Ardon, Hilko, additional, Auslands, Kaspars, additional, Azouvi, Philippe, additional, Luisa Azzolini, Maria, additional, Baciu, Camelia, additional, Badenes, Rafael, additional, Bartels, Ronald, additional, Barzó, Pál, additional, Bauerfeind, Ursula, additional, Beauvais, Romuald, additional, Beer, Ronny, additional, Belda, Francisco Javier, additional, Bellander, Bo Michael, additional, Belli, Antonio, additional, Bellier, Rémy, additional, Benali, Habib, additional, Benard, Thierry, additional, Berardino, Maurizio, additional, Beretta, Luigi, additional, Beynon, Christopher, additional, Bilotta, Federico, additional, Binder, Harald, additional, Biqiri, Erta, additional, Blaabjerg, Morten, additional, Boogert, Hugo den, additional, Bragge, Peter, additional, Brazinova, Alexandra, additional, Brinck, Vibeke, additional, Brooker, Joanne, additional, Brorsson, Camilla, additional, Buki, Andras, additional, Bullinger, Monika, additional, Cabeleira, Manuel, additional, Calappi, Emiliana, additional, Calvi, Maria Rosa, additional, Cameron, Peter, additional, Carbayo, Lozano Guillermo, additional, Carbonara, Marco, additional, Carise, Elsa, additional, Carpenter, K., additional, Castaño León, Ana M., additional, Causin, Francesco, additional, Chevallard, Giorgio, additional, Chieregato, Arturo, additional, Citerio, Giuseppe, additional, Cnossen, Maryse, additional, Coburn, Mark, additional, Coles, Jonathan, additional, Coles-Kemp, Lizzie, additional, Collett, Johnny, additional, Cooper, Jamie D., additional, Correia, Marta, additional, Covic, Amra, additional, Curry, Nicola, additional, Czeiter, Endre, additional, Czosnyka, Marek, additional, Fizelier, Claire Dahyot, additional, Damas, François, additional, Damas, Pierre, additional, Dawes, Helen, additional, De Keyser, Véronique, additional, Corte, Francesco Della, additional, Depreitere, Bart, additional, de Ruiter, Godard C.W., additional, Dilvesi, Dula, additional, Ding, Shenghao, additional, Dippel, Diederik, additional, Dixit, Abhishek, additional, Donoghue, Emma, additional, Dreier, Jens, additional, Dulière, Guy Loup, additional, Engemann, Heiko, additional, Ercole, Ari, additional, Esser, Patrick, additional, Ezer, Erzsébet, additional, Fabricius, Martin, additional, Feigin, Valery L., additional, Feng, Junfeng, additional, Foks, Kelly, additional, Fossi, Francesca, additional, Francony, Gilles, additional, Freo, Ulderico, additional, Frisvold, Shirin, additional, Furmanov, Alex, additional, Gagliardo, Pablo, additional, Galanaud, Damien, additional, Gantner, Dashiell, additional, Gao, Guoyi, additional, Geleijns, Karin, additional, George, Pradeep, additional, Ghuysen, Alexandre, additional, Giga, Lelde, additional, Giraud, Benoit, additional, Glocker, Ben, additional, Golubovic, Jagos, additional, Gomez, Pedro A., additional, Gravesteijn, Benjamin, additional, Grossi, Francesca, additional, Gruen, Russell L., additional, Gupta, Deepak, additional, Haagsma, Juanita A., additional, Håberg, Asta Kristine, additional, Jacobs, Bram, additional, Haitsma, Iain, additional, Hartings, Jed A., additional, Helbok, Raimund, additional, Helseth, Eirik, additional, Hertle, Daniel, additional, Hoedemaekers, Astrid, additional, Hoefer, Stefan, additional, Horton, Lindsay, additional, Huijben, Jilske, additional, Hutchinson, Peter J., additional, Jankowski, Stefan, additional, Jarrett, Mike, additional, Jelaca, Bojan, additional, Jiang, Ji yao, additional, Jones, Kelly, additional, Kamnitsas, Konstantinos, additional, Karan, Mladen, additional, Katila, Ari, additional, Kaukonen, Maija, additional, Kerforne, Thomas, additional, Kivisaari, Riku, additional, Kolias, Angelos G., additional, Kolumbán, Bálint, additional, Kompanje, Erwin, additional, Kolundzija, Ksenija, additional, Kondziella, Daniel, additional, Koskinen, Lars Owe, additional, Kovács, Noémi, additional, Lagares, Alfonso, additional, Lanyon, Linda, additional, Laureys, Steven, additional, Lecky, Fiona, additional, Ledig, Christian, additional, Lefering, Rolf, additional, Legrand, Valerie, additional, Lei, Jin, additional, Levi, Leon, additional, Lightfoot, Roger, additional, Lingsma, Hester, additional, Loeckx, Dirk, additional, Lozano, Angels, additional, Maas, Andrew I.R., additional, MacDonald, Stephen, additional, Maegele, Marc, additional, Marek, Majdan, additional, Major, Sebastian, additional, Manara, Alex, additional, Manley, Geoffrey, additional, Martin, Didier, additional, Martin, Leon Francisco, additional, Martino, Costanza, additional, Maréchal, Hugues, additional, Maruenda, Armando, additional, Masala, Alessandro, additional, Mattern, Julia, additional, McFadyen, Charles, additional, McMahon, Catherine, additional, Melegh, Béla, additional, Menon, David, additional, Menovsky, Tomas, additional, Kossmann, Cristina Morganti, additional, Mulazzi, Davide, additional, Mühlan, Holger, additional, Muraleedharan, Visakh, additional, Murray, Lynnette, additional, Nair, Nandesh, additional, Negru, Ancuta, additional, Nelson, David, additional, Newcombe, Virginia, additional, Nieboer, Daan, additional, Noirhomme, Quentin, additional, Nyirádi, József, additional, Oddo, Mauro, additional, Oldenbeuving, Annemarie, additional, Oresic, Matej, additional, Ortolano, Fabrizio, additional, Palotie, Aarno, additional, Parizel, Paul M., additional, Patruno, Adriana, additional, Payen, Jean François, additional, Perera, Natascha, additional, Perlbarg, Vincent, additional, Persona, Paolo, additional, Peul, Wilco, additional, Piippo-Karjalainen, Anna, additional, Pili, Floury Sébastien, additional, Pirinen, Matti, additional, Ples, Horia, additional, Poca, Maria Antonia, additional, Polinder, Suzanne, additional, Pomposo, Inigo, additional, Posti, Jussi, additional, Puybasset, Louis, additional, Radoi, Andreea, additional, Ragauskas, Arminas, additional, Raj, Rahul, additional, Rambadagalla, Malinka, additional, Real, Ruben, additional, Rehorčíková, Veronika, additional, Rhodes, Jonathan, additional, Ripatti, Samuli, additional, Rocka, Saulius, additional, Roe, Cecilie, additional, Roise, Olav, additional, Roks, Gerwin, additional, Rosenfeld, Jeffrey, additional, Rosenlund, Christina, additional, Rosenthal, Guy, additional, Rossaint, Rolf, additional, Rossi, Sandra, additional, Rueckert, Daniel, additional, Rusnák, Martin, additional, Sacchi, Marco, additional, Sahakian, Barbara, additional, Sahuquillo, Juan, additional, Sakowitz, Oliver, additional, Sala, Francesca, additional, Porras, Renan Sanchez, additional, Sandor, Janos, additional, Santos, Edgar, additional, Sasu, Luminita, additional, Savo, Davide, additional, Schäffer, Nadine, additional, Schipper, Inger, additional, Schlößer, Barbara, additional, Schmidt, Silke, additional, Schoechl, Herbert, additional, Schoonman, Guus, additional, Schou, Rico Frederik, additional, Schwendenwein, Elisabeth, additional, Schöll, Michael, additional, Sewalt, Charlie, additional, Sir, Özcan, additional, Skandsen, Toril, additional, Smakman, Lidwien, additional, Smeets, Dirk, additional, Smielewski, Peter, additional, Sorinola, Abayomi, additional, Stamatakis, Emmanuel, additional, Stanworth, Simon, additional, Steinbüchel, Nicole, additional, Stevanovic, Ana, additional, Stevens, Robert, additional, Stewart, William, additional, Steyerberg, Ewout W., additional, Stocchetti, Nino, additional, Sundström, Nina, additional, Synnot, Anneliese, additional, Taccone, Fabio Silvio, additional, Takala, Riikka, additional, Tamás, Viktória, additional, Tanskanen, Päivi, additional, Taylor, Mark Steven, additional, Te Ao, Braden, additional, Tenovuo, Olli, additional, Telgmann, Ralph, additional, Teodorani, Guido, additional, Theadom, Alice, additional, Thomas, Matt, additional, Tibboel, Dick, additional, Tolias, Christos, additional, Tshibanda, Jean Flory Luaba, additional, Trapani, Tony, additional, Tudora, Cristina Maria, additional, Vajkoczy, Peter, additional, Vallance, Shirley, additional, Valeinis, Egils, additional, der Steen, Gregory Van, additional, der Jagt, Mathieu van, additional, de Naalt, JV, additional, van Dijck, Jeroen T.J.M., additional, van Essen, Thomas A., additional, Hecke, Wim Van, additional, Heugten, Caroline van, additional, Praag, Dominique Van, additional, Vyvere, Thijs Vande, additional, Waesberghe, Julia Van, additional, Vanhaudenhuyse, Audrey, additional, Vargiolu, Alessia, additional, Vega, Emmanuel, additional, Velt, Kimberley, additional, Verheyden, Jan, additional, Vespa, Paul M., additional, Vik, Anne, additional, Vilcinis, Rimantas, additional, Vizzino, Giacinta, additional, Lankamp, Carmen Vleggeert, additional, Volovici, Victor, additional, Voormolen, Daphne, additional, Vulekovic, Peter, additional, Vámos, Zoltán, additional, Wade, Derick, additional, Wang, Kevin K.W., additional, Wang, Lei, additional, Wessels, Lars, additional, Wiegers, Eveline, additional, Wildschut, Eno, additional, Williams, Guy, additional, Wilson, Lindsay, additional, Winkler, Maren K.L., additional, Wolf, Stefan, additional, Ylén, Peter, additional, Younsi, Alexander, additional, Zaaroor, Menashe, additional, Zeiler, Frederik, additional, Zhihui, Yang, additional, Ziverte, Agate, additional, and Zumbo, Fabrizio, additional

Published
2021
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25. Safety and efficacy of C1-inhibitor in traumatic brain injury (CIAO@TBI):study protocol for a randomized, placebo-controlled, multi-center trial

Author

van Erp, Inge A.M., van Essen, Thomas A., Fluiter, Kees, van Zwet, Erik, van Vliet, Peter, Baas, Frank, Haitsma, Iain, Verbaan, Dagmar, Coert, Bert, de Ruiter, Godard C.W., Moojen, Wouter A., van der Jagt, Mathieu, Peul, Wilco C., van Erp, Inge A.M., van Essen, Thomas A., Fluiter, Kees, van Zwet, Erik, van Vliet, Peter, Baas, Frank, Haitsma, Iain, Verbaan, Dagmar, Coert, Bert, de Ruiter, Godard C.W., Moojen, Wouter A., van der Jagt, Mathieu, and Peul, Wilco C.

Abstract

Background: Traumatic brain injury (TBI) is a major cause of death and disability across all ages. After the primary impact, the pathophysiologic process of secondary brain injury consists of a neuroinflammation response that critically leads to irreversible brain damage in the first days after the trauma. A key catalyst in this inflammatory process is the complement system. Inhibiting the complement system could therefore be a therapeutic target in TBI. Objective: To study the safety and efficacy of C1-inhibitor (C1-INH) compared to placebo in patients with TBI. By temporarily blocking the complement system, we hypothesize a decrease in the posttraumatic neuroinflammatory response resulting in a less unfavorable clinical outcome for TBI patients. Methods: CIAO@TBI is a multicenter, randomized, blinded, phase II placebo-controlled trial. Adult TBI patients with GCS < 13 requiring intracranial pressure (ICP) monitoring will be randomized, using block randomization, within 12 h after trauma to one dose 6000 IU C1-INH or placebo. A total of 106 patients will be included, and follow-up will occur up to 12 months. The primary endpoints are (1) Therapy Intensity Level (TIL) Scale, (2) Glasgow Outcome Scale-Extended (GOSE) at 6 months, and (3) complication rate during hospitalization. Outcomes will be determined by a trial nurse blinded for the treatment allocation. Analyses will be conducted in an intention-to-treat analysis. Discussion: We expect that C1-INH administration will be safe and potentially effective to improve clinical outcomes by reducing neuroinflammation in TBI patients. Trial registration: ClinicalTrials.gov NCT04489160. Registered on 27 July 2020. EudraCT 2020-000140-58.

Published
2021

29. Correction to:Variation in neurosurgical management of traumatic brain injury: a survey in 68 centers participating in the CENTER-TBI study (Acta Neurochirurgica, (2019), 161, 3, (435-449), 10.1007/s00701-018-3761-z)

Author

van Essen, Thomas A., Cnossen, Maryse C., de Ruiter, Godard C.W., Haitsma, Iain, Polinder, Suzanne, Steyerberg, Ewout W., Menon, David, Maas, Andrew I.R., Lingsma, Hester F., Peul, Wilco C., and Ylén, Peter

Abstract

The names of themembers of the IOPSMS study Group was inverted in the original paper and is now corrected in this article.

Published
2019
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33. Variation in neurosurgical management of traumatic brain injury

Author

van Essen, T.A. (Thomas A.), den Boogert, H.F. (Hugo F.), Cnossen, M.C. (Maryse), De Ruiter, G.C.W. (Godard C.W.), Haitsma, I. (Iain), Polinder, S. (Suzanne), Steyerberg, E.W. (Ewout), Menon, D.K. (David ), Maas, A.I.R. (Andrew), Lingsma, H.F. (Hester), Peul, W.C. (Wilco), Cecilia, A. (Ackerlund), Hadie, A. (Adams), Vanni, A. (Agnoletti), Judith, A. (Allanson), Krisztina, A. (Amrein), Norberto, A. (Andaluz), Nada, A. (Andelic), Lasse, A. (Andreassen), Azasevac, A. (Antun), Audny, A. (Anke), Anna, A. (Antoni), Hilko, A. (Ardon), Gérard, A. (Audibert), Kaspars, A. (Auslands), Philippe, A. (Azouvi), Luisa, A.M. (Azzolini Maria), Camelia, B. (Baciu), Rafael, B. (Badenes), Ronald, B. (Bartels), Pál, B. (Barzó), Ursula, B. (Bauerfeind), Romuald, B. (Beauvais), Ronny, B. (Beer), Javier, B.F. (Belda Francisco), Bo-Michael, B. (Bellander), Antonio, B. (Belli), Rémy, B. (Bellier), Habib, B. (Benali), Thierry, B. (Benard), Maurizio, B. (Berardino), Luigi, B. (Beretta), Christopher, B. (Beynon), Federico, B. (Bilotta), Harald, B. (Binder), Erta, B. (Biqiri), Morten, B. (Blaabjerg), den Hugo, B. (Boogert), Pierre, B. (Bouzat), Peter, B. (Bragge), Alexandra, B. (Brazinova), Vibeke, B. (Brinck), Joanne, B. (Brooker), Camilla, B. (Brorsson), Andras, B. (Buki), Monika, B. (Bullinger), Emiliana, C. (Calappi), Rosa, C.M. (Calvi Maria), Peter, C. (Cameron), Guillermo, C.L. (Carbayo Lozano), Marco, C. (Carbonara), Elsa, C. (Carise), Carpenter, K.L.H. (Keri L.H.), Castaño-León Ana, M. (M.), Francesco, C. (Causin), Giorgio, C. (Chevallard), Arturo, C. (Chieregato), Giuseppe, C. (Citerio), Maryse, C. (Cnossen), Mark, C. (Coburn), Jonathan, C. (Coles), Lizzie, C.-K. (Coles-Kemp), Johnny, C. (Collett), Cooper Jamie, D. (D.), Marta, C. (Correia), Amra, C. (Covic), Nicola, C. (Curry), Endre, C. (Czeiter), Marek, C. (Czosnyka), Claire, D.-F. (Dahyot-Fizelier), François, D. (Damas), Pierre, D. (Damas), Helen, D. (Dawes), Véronique, D.K. (De Keyser), Francesco, D.C. (Della Corte), Bart, D. (Depreitere), de Ruiter Godard, C.W. (C. W.), Dula, D. (Dilvesi), Shenghao, D. (Ding), Diederik, D. (Dippel), Abhishek, D. (Dixit), Emma, D. (Donoghue), Jens, D. (Dreier), Guy-Loup, D. (Dulière), George, E. (Eapen), Heiko, E. (Engemann), Ari, E. (Ercole), Patrick, E. (Esser), Erzsébet, E. (Ezer), Martin, F. (Fabricius), Feigin Valery, L. (L.), Junfeng, F. (Feng), Kelly, F. (Foks), Francesca, F. (Fossi), Gilles, F. (Francony), Ulderico, F. (Freo), Shirin, F. (Frisvold), Alex, F. (Furmanov), Pablo, G. (Gagliardo), Damien, G. (Galanaud), Dashiell, G. (Gantner), Guoyi, G. (Gao), Karin, G. (Geleijns), Pradeep, G. (George), Alexandre, G. (Ghuysen), Lelde, G. (Giga), Benoit, G. (Giraud), Ben, G. (Glocker), Jagos, G. (Golubovic), Gomez Pedro, A. (A.), Francesca, G. (Grossi), Gruen Russell, L. (L.), Deepak, G. (Gupta), Haagsma Juanita, A. (A.), Iain, H. (Haitsma), Hartings Jed, A. (A.), Raimund, H. (Helbok), Eirik, H. (Helseth), Daniel, H. (Hertle), Astrid, H. (Hoedemaekers), Stefan, H. (Hoefer), Lindsay, H. (Horton), Jilske, H. (Huijben), Hutchinson Peter, J. (J.), Kristine, H.A. (Håberg Asta), Bram, J. (Jacobs), Stefan, J. (Jankowski), Mike, J. (Jarrett), Bojan, J. (Jelaca), Ji-yao, J. (Jiang), Kelly, J. (Jones), Konstantinos, K. (Kamnitsas), Mladen, K. (Karan), Ari, K. (Katila), Maija, K. (Kaukonen), Thomas, K. (Kerforne), Riku, K. (Kivisaari), Kolias Angelos, G. (G.), Bálint, K. (Kolumbán), Erwin, K. (Kompanje), Ksenija, K. (Kolundzija), Daniel, K. (Kondziella), Lars-Owe, K. (Koskinen), Noémi, K. (Kovács), Alfonso, L. (Lagares), Linda, L. (Lanyon), Steven, L. (Laureys), Fiona, L. (Lecky), Christian, L. (Ledig), Rolf, L. (Lefering), Valerie, L. (Legrand), Jin, L. (Lei), Leon, L. (Levi), Roger, L. (Lightfoot), Hester, L. (Lingsma), Dirk, L. (Loeckx), Angels, L. (Lozano), Maas Andrew, I.R. (I. R.), Stephen, M.D. (MacDonald), Marc, M. (Maegele), Marek, M. (Majdan), Sebastian, M. (Major), Alex, M. (Manara), Geoffrey, M. (Manley), Didier, M. (Martin), Francisco, M.L. (Martin Leon), Costanza, M. (Martino), Armando, M. (Maruenda), Hugues, M. (Maréchal), Alessandro, M. (Masala), Julia, M. (Mattern), Charles, M.F. (McFadyen), Catherine, M.M. (McMahon), Béla, M. (Melegh), David, M. (Menon), Tomas, M. (Menovsky), Cristina, M.-K. (Morganti-Kossmann), Davide, M. (Mulazzi), Visakh, M. (Muraleedharan), Lynnette, M. (Murray), Holger, M. (Mühlan), Nandesh, N. (Nair), Ancuta, N. (Negru), David, N. (Nelson), Virginia, N. (Newcombe), Daan, N. (Nieboer), Quentin, N. (Noirhomme), József, N. (Nyirádi), Mauro, O. (Oddo), Annemarie, O. (Oldenbeuving), Matej, O. (Oresic), Fabrizio, O. (Ortolano), Aarno, P. (Palotie), Parizel Paul, M. (M.), Adriana, P. (Patruno), Jean-François, P. (Payen), Natascha, P. (Perera), Vincent, P. (Perlbarg), Paolo, P. (Persona), Wilco, P. (Peul), Anna, P.-K. (Piippo-Karjalainen), Sébastien, P.F. (Pili Floury), Matti, P. (Pirinen), Horia, P. (Ples), Antonia, P.M. (Poca Maria), Suzanne, P. (Polinder), Inigo, P. (Pomposo), Jussi, P. (Posti), Louis, P. (Puybasset), Andreea, R. (Radoi), Arminas, R. (Ragauskas), Rahul, R. (Raj), Malinka, R. (Rambadagalla), Ruben, R. (Real), Veronika, R. (Rehorčíková), Jonathan, R. (Rhodes), Samuli, R. (Ripatti), Saulius, R. (Rocka), Cecilie, R. (Roe), Olav, R. (Roise), Gerwin, R. (Roks), Jonathan, R. (Rosand), Jeffrey, R. (Rosenfeld), Christina, R. (Rosenlund), Guy, R. (Rosenthal), Rolf, R. (Rossaint), Sandra, R. (Rossi), Daniel, R. (Rueckert), Martin, R. (Rusnák), Marco, S. (Sacchi), Barbara, S. (Sahakian), Juan, S. (Sahuquillo), Oliver, S. (Sakowitz), Francesca, S. (Sala), Renan, S.-P. (Sanchez-Porras), Janos, S. (Sandor), Edgar, S. (Santos), Luminita, S. (Sasu), Davide, S. (Savo), Nadine, S. (Schäffer), Inger, S. (Schipper), Barbara, S.ß. (Schlößer), Silke, S. (Schmidt), Herbert, S. (Schoechl), Guus, S. (Schoonman), Frederik, S.R. (Schou Rico), Elisabeth, S. (Schwendenwein), Michael, S. (Schöll), Özcan, S. (Sir), Toril, S. (Skandsen), Lidwien, S. (Smakman), Dirk, S. (Smeets), Peter, S. (Smielewski), Abayomi, S. (Sorinola), Emmanuel, S. (Stamatakis), Simon, S. (Stanworth), Nicole, S. (Steinbüchel), Ana, S. (Stevanovic), Robert, S. (Stevens), William, S. (Stewart), Steyerberg Ewout, W. (W.), Nino, S. (Stocchetti), Nina, S. (Sundström), Anneliese, S. (Synnot), Silvio, T.F. (Taccone Fabio), Riikka, T. (Takala), Viktória, T. (Tamás), Päivi, T. (Tanskanen), Steven, T.M. (Taylor Mark), Braden, T.A. (Te Ao), Olli, T. (Tenovuo), Ralph, T. (Telgmann), Guido, T. (Teodorani), Alice, T. (Theadom), Matt, T. (Thomas), Dick, T. (Tibboel), Christos, T. (Tolias), Luaba, T.J.-F. (Tshibanda Jean-Flory), Tony, T. (Trapani), Maria, T.C. (Tudora Cristina), Peter, V. (Vajkoczy), Shirley, V. (Vallance), Egils, V. (Valeinis), der Steen Gregory, V. (Van), van der Mathieu, J. (Jagt), van der Joukje, N. (Naalt), van Dijck Jeroen, T.J.M. (T. J.M.), van Essen Thomas, A. (A.), Wim, V.H. (Van Hecke), van Caroline, H. (Heugten), Dominique, V.P. (Van Praag), Thijs, V.V. (Vande Vyvere), Julia, V.W. (Van Waesberghe), Audrey, V. (Vanhaudenhuyse), Alessia, V. (Vargiolu), Emmanuel, V. (Vega), Kimberley, V. (Velt), Jan, V. (Verheyden), Vespa Paul, M. (M.), Anne, V. (Vik), Rimantas, V. (Vilcinis), Giacinta, V. (Vizzino), Carmen, V.-L. (Vleggeert-Lankamp), Victor, V. (Volovici), Voormolen, D.C. (Daphne), Peter, V. (Vulekovic), Zoltán, V. (Vámos), Derick, W. (Wade), Wang Kevin, K.W. (K. W.), Lei, W. (Wang), Lars, W. (Wessels), Eno, W. (Wildschut), Guy, W. (Williams), Lindsay, W. (Wilson), Winkler Maren, K.L. (K. L.), Stefan, W. (Wolf), Peter, Y. (Ylén), Alexander, Y. (Younsi), Menashe, Z. (Zaaroor), Yang, Z. (Zhihui), Agate, Z. (Ziverte), Fabrizio, Z. (Zumbo), van Essen, T.A. (Thomas A.), den Boogert, H.F. (Hugo F.), Cnossen, M.C. (Maryse), De Ruiter, G.C.W. (Godard C.W.), Haitsma, I. (Iain), Polinder, S. (Suzanne), Steyerberg, E.W. (Ewout), Menon, D.K. (David ), Maas, A.I.R. (Andrew), Lingsma, H.F. (Hester), Peul, W.C. (Wilco), Cecilia, A. (Ackerlund), Hadie, A. (Adams), Vanni, A. (Agnoletti), Judith, A. (Allanson), Krisztina, A. (Amrein), Norberto, A. (Andaluz), Nada, A. (Andelic), Lasse, A. (Andreassen), Azasevac, A. (Antun), Audny, A. (Anke), Anna, A. (Antoni), Hilko, A. (Ardon), Gérard, A. (Audibert), Kaspars, A. (Auslands), Philippe, A. (Azouvi), Luisa, A.M. (Azzolini Maria), Camelia, B. (Baciu), Rafael, B. (Badenes), Ronald, B. (Bartels), Pál, B. (Barzó), Ursula, B. (Bauerfeind), Romuald, B. (Beauvais), Ronny, B. (Beer), Javier, B.F. (Belda Francisco), Bo-Michael, B. (Bellander), Antonio, B. (Belli), Rémy, B. (Bellier), Habib, B. (Benali), Thierry, B. (Benard), Maurizio, B. (Berardino), Luigi, B. (Beretta), Christopher, B. (Beynon), Federico, B. (Bilotta), Harald, B. (Binder), Erta, B. (Biqiri), Morten, B. (Blaabjerg), den Hugo, B. (Boogert), Pierre, B. (Bouzat), Peter, B. (Bragge), Alexandra, B. (Brazinova), Vibeke, B. (Brinck), Joanne, B. (Brooker), Camilla, B. (Brorsson), Andras, B. (Buki), Monika, B. (Bullinger), Emiliana, C. (Calappi), Rosa, C.M. (Calvi Maria), Peter, C. (Cameron), Guillermo, C.L. (Carbayo Lozano), Marco, C. (Carbonara), Elsa, C. (Carise), Carpenter, K.L.H. (Keri L.H.), Castaño-León Ana, M. (M.), Francesco, C. (Causin), Giorgio, C. (Chevallard), Arturo, C. (Chieregato), Giuseppe, C. (Citerio), Maryse, C. (Cnossen), Mark, C. (Coburn), Jonathan, C. (Coles), Lizzie, C.-K. (Coles-Kemp), Johnny, C. (Collett), Cooper Jamie, D. (D.), Marta, C. (Correia), Amra, C. (Covic), Nicola, C. (Curry), Endre, C. (Czeiter), Marek, C. (Czosnyka), Claire, D.-F. (Dahyot-Fizelier), François, D. (Damas), Pierre, D. (Damas), Helen, D. (Dawes), Véronique, D.K. (De Keyser), Francesco, D.C. (Della Corte), Bart, D. (Depreitere), de Ruiter Godard, C.W. (C. W.), Dula, D. (Dilvesi), Shenghao, D. (Ding), Diederik, D. (Dippel), Abhishek, D. (Dixit), Emma, D. (Donoghue), Jens, D. (Dreier), Guy-Loup, D. (Dulière), George, E. (Eapen), Heiko, E. (Engemann), Ari, E. (Ercole), Patrick, E. (Esser), Erzsébet, E. (Ezer), Martin, F. (Fabricius), Feigin Valery, L. (L.), Junfeng, F. (Feng), Kelly, F. (Foks), Francesca, F. (Fossi), Gilles, F. (Francony), Ulderico, F. (Freo), Shirin, F. (Frisvold), Alex, F. (Furmanov), Pablo, G. (Gagliardo), Damien, G. (Galanaud), Dashiell, G. (Gantner), Guoyi, G. (Gao), Karin, G. (Geleijns), Pradeep, G. (George), Alexandre, G. (Ghuysen), Lelde, G. (Giga), Benoit, G. (Giraud), Ben, G. (Glocker), Jagos, G. (Golubovic), Gomez Pedro, A. (A.), Francesca, G. (Grossi), Gruen Russell, L. (L.), Deepak, G. (Gupta), Haagsma Juanita, A. (A.), Iain, H. (Haitsma), Hartings Jed, A. (A.), Raimund, H. (Helbok), Eirik, H. (Helseth), Daniel, H. (Hertle), Astrid, H. (Hoedemaekers), Stefan, H. (Hoefer), Lindsay, H. (Horton), Jilske, H. (Huijben), Hutchinson Peter, J. (J.), Kristine, H.A. (Håberg Asta), Bram, J. (Jacobs), Stefan, J. (Jankowski), Mike, J. (Jarrett), Bojan, J. (Jelaca), Ji-yao, J. (Jiang), Kelly, J. (Jones), Konstantinos, K. (Kamnitsas), Mladen, K. (Karan), Ari, K. (Katila), Maija, K. (Kaukonen), Thomas, K. (Kerforne), Riku, K. (Kivisaari), Kolias Angelos, G. (G.), Bálint, K. (Kolumbán), Erwin, K. (Kompanje), Ksenija, K. (Kolundzija), Daniel, K. (Kondziella), Lars-Owe, K. (Koskinen), Noémi, K. (Kovács), Alfonso, L. (Lagares), Linda, L. (Lanyon), Steven, L. (Laureys), Fiona, L. (Lecky), Christian, L. (Ledig), Rolf, L. (Lefering), Valerie, L. (Legrand), Jin, L. (Lei), Leon, L. (Levi), Roger, L. (Lightfoot), Hester, L. (Lingsma), Dirk, L. (Loeckx), Angels, L. (Lozano), Maas Andrew, I.R. (I. R.), Stephen, M.D. (MacDonald), Marc, M. (Maegele), Marek, M. (Majdan), Sebastian, M. (Major), Alex, M. (Manara), Geoffrey, M. (Manley), Didier, M. (Martin), Francisco, M.L. (Martin Leon), Costanza, M. (Martino), Armando, M. (Maruenda), Hugues, M. (Maréchal), Alessandro, M. (Masala), Julia, M. (Mattern), Charles, M.F. (McFadyen), Catherine, M.M. (McMahon), Béla, M. (Melegh), David, M. (Menon), Tomas, M. (Menovsky), Cristina, M.-K. (Morganti-Kossmann), Davide, M. (Mulazzi), Visakh, M. (Muraleedharan), Lynnette, M. (Murray), Holger, M. (Mühlan), Nandesh, N. (Nair), Ancuta, N. (Negru), David, N. (Nelson), Virginia, N. (Newcombe), Daan, N. (Nieboer), Quentin, N. (Noirhomme), József, N. (Nyirádi), Mauro, O. (Oddo), Annemarie, O. (Oldenbeuving), Matej, O. (Oresic), Fabrizio, O. (Ortolano), Aarno, P. (Palotie), Parizel Paul, M. (M.), Adriana, P. (Patruno), Jean-François, P. (Payen), Natascha, P. (Perera), Vincent, P. (Perlbarg), Paolo, P. (Persona), Wilco, P. (Peul), Anna, P.-K. (Piippo-Karjalainen), Sébastien, P.F. (Pili Floury), Matti, P. (Pirinen), Horia, P. (Ples), Antonia, P.M. (Poca Maria), Suzanne, P. (Polinder), Inigo, P. (Pomposo), Jussi, P. (Posti), Louis, P. (Puybasset), Andreea, R. (Radoi), Arminas, R. (Ragauskas), Rahul, R. (Raj), Malinka, R. (Rambadagalla), Ruben, R. (Real), Veronika, R. (Rehorčíková), Jonathan, R. (Rhodes), Samuli, R. (Ripatti), Saulius, R. (Rocka), Cecilie, R. (Roe), Olav, R. (Roise), Gerwin, R. (Roks), Jonathan, R. (Rosand), Jeffrey, R. (Rosenfeld), Christina, R. (Rosenlund), Guy, R. (Rosenthal), Rolf, R. (Rossaint), Sandra, R. (Rossi), Daniel, R. (Rueckert), Martin, R. (Rusnák), Marco, S. (Sacchi), Barbara, S. (Sahakian), Juan, S. (Sahuquillo), Oliver, S. (Sakowitz), Francesca, S. (Sala), Renan, S.-P. (Sanchez-Porras), Janos, S. (Sandor), Edgar, S. (Santos), Luminita, S. (Sasu), Davide, S. (Savo), Nadine, S. (Schäffer), Inger, S. (Schipper), Barbara, S.ß. (Schlößer), Silke, S. (Schmidt), Herbert, S. (Schoechl), Guus, S. (Schoonman), Frederik, S.R. (Schou Rico), Elisabeth, S. (Schwendenwein), Michael, S. (Schöll), Özcan, S. (Sir), Toril, S. (Skandsen), Lidwien, S. (Smakman), Dirk, S. (Smeets), Peter, S. (Smielewski), Abayomi, S. (Sorinola), Emmanuel, S. (Stamatakis), Simon, S. (Stanworth), Nicole, S. (Steinbüchel), Ana, S. (Stevanovic), Robert, S. (Stevens), William, S. (Stewart), Steyerberg Ewout, W. (W.), Nino, S. (Stocchetti), Nina, S. (Sundström), Anneliese, S. (Synnot), Silvio, T.F. (Taccone Fabio), Riikka, T. (Takala), Viktória, T. (Tamás), Päivi, T. (Tanskanen), Steven, T.M. (Taylor Mark), Braden, T.A. (Te Ao), Olli, T. (Tenovuo), Ralph, T. (Telgmann), Guido, T. (Teodorani), Alice, T. (Theadom), Matt, T. (Thomas), Dick, T. (Tibboel), Christos, T. (Tolias), Luaba, T.J.-F. (Tshibanda Jean-Flory), Tony, T. (Trapani), Maria, T.C. (Tudora Cristina), Peter, V. (Vajkoczy), Shirley, V. (Vallance), Egils, V. (Valeinis), der Steen Gregory, V. (Van), van der Mathieu, J. (Jagt), van der Joukje, N. (Naalt), van Dijck Jeroen, T.J.M. (T. J.M.), van Essen Thomas, A. (A.), Wim, V.H. (Van Hecke), van Caroline, H. (Heugten), Dominique, V.P. (Van Praag), Thijs, V.V. (Vande Vyvere), Julia, V.W. (Van Waesberghe), Audrey, V. (Vanhaudenhuyse), Alessia, V. (Vargiolu), Emmanuel, V. (Vega), Kimberley, V. (Velt), Jan, V. (Verheyden), Vespa Paul, M. (M.), Anne, V. (Vik), Rimantas, V. (Vilcinis), Giacinta, V. (Vizzino), Carmen, V.-L. (Vleggeert-Lankamp), Victor, V. (Volovici), Voormolen, D.C. (Daphne), Peter, V. (Vulekovic), Zoltán, V. (Vámos), Derick, W. (Wade), Wang Kevin, K.W. (K. W.), Lei, W. (Wang), Lars, W. (Wessels), Eno, W. (Wildschut), Guy, W. (Williams), Lindsay, W. (Wilson), Winkler Maren, K.L. (K. L.), Stefan, W. (Wolf), Peter, Y. (Ylén), Alexander, Y. (Younsi), Menashe, Z. (Zaaroor), Yang, Z. (Zhihui), Agate, Z. (Ziverte), and Fabrizio, Z. (Zumbo)

Abstract

Background: Neurosurgical management of traumatic brain injury (TBI) is challenging, with only low-quality evidence. We aimed to explore differences in neurosurgical strategies for TBI across Europe. Methods: A survey was sent to 68 centers participating in the Collaborative European Neurotrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study. The questionnaire contained 21 questions, including the decision when to operate (or not) on traumatic acute subdural hematoma (ASDH) and intracerebral hematoma (ICH), and when to perform a decompressive craniectomy (DC) in raised intracranial pressure (ICP). Results: The survey was completed by 68 centers (100%). On average, 10 neurosurgeons work in each trauma center. In all centers, a neurosurgeon was available within 30 min. Forty percent of responders reported a thickness or volume threshold for evacuation of an ASDH. Most responders (78%) decide on a primary DC in evacuating an ASDH during the operation, when swelling is present. For ICH, 3% would perform an evacuation directly to prevent secondary deterioration and 66% only in case of clinical deterioration. Most respondents (91%) reported to consider a DC for refractory high ICP. The reported cut-off ICP for DC in refractory high ICP, however, differed: 60% uses 25 mmHg, 18% 30 mmHg, and 17% 20 mmHg. Treatment strategies varied substantially between regions, specifically for the threshold for ASDH surgery and DC for refractory raised ICP. Also within center variation was present: 31% reported variation within the hospital for inserting an ICP monitor and 43% for evacuating mass lesions. Conclusion: Despite a homogeneous organization, considerable practice variation exists of neurosurgical strategies for TBI in Europe. These results provide an incentive for comparative effectiveness research to determine elements of effective neurosurgical care.

Published
2018
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40. Brain death and postmortem organ donation: report of a questionnaire from the CENTER-TBI study

Author

Van Veen E., Van Der Jagt M., Cnossen M. C., Maas A. I. R., De Beaufort I. D., Menon D. K., Citerio G., Stocchetti N., Rietdijk W. J. R., Van Dijck J. T. J. M., Kompanje E. J. O., Ackerlund C., Adams H., Agnoletti V., Allanson J., Amrein K., Andaluz N., Andelic N., Andreassen L., Antun A., Anke A., Antoni A., Ardon H., Audibert G., Auslands K., Azouvi P., Azzolini M. L., Baciu C., Badenes R., Bartels R., Barzo P., Bauerfeind U., Beauvais R., Beer R., Francisco J. B., Bellander B. -M., Belli A., Bellier R., Benali H., Benard T., Berardino M., Beretta L., Beynon C., Bilotta F., Binder H., Biqiri E., Blaabjerg M., Den Boogert H., Bouzat P., Bragge P., Brazinova A., Brinck V., Brooker J., Brorsson C., Buki A., Bullinger M., Calappi E., Calvi M. R., Cameron P., Lozano G. C., Carbonara M., Carise E., Carpenter K., Castano-Leon A. M., Causin F., Chevallard G., Chieregato A., Coburn M., Coles J., Coles-Kemp L., Collett J., Cooper J. D., Correia M., Covic A., Curry N., Czeiter E., Czosnyka M., Dahyot-Fizelier C., Damas F., Damas P., Dawes H., De Keyser V., Della Corte F., Depreitere B., De Ruiter Godard C. W., Dilvesi D., Ding S., Dippel D., Dixit A., Donoghue E., Dreier J., Duliere G. -L., Eapen G., Engemann H., Ercole A., Esser P., Ezer E., Fabricius M., Feigin V. L., Feng J., Foks K., Fossi F., Francony G., Freo U., Frisvold S., Furmanov A., Gagliardo P., Galanaud D., Gantner D., Gao G., Geleijns K., George P., Ghuysen A., Giga L., Giraud B., Glocker B., Golubovic J., Gomez P. A., Grossi F., Gruen R. L., Gupta D., Haagsma J. A., Haitsma I., Hartings J. A., Helbok R., Helseth E., Hertle D., Hoedemaekers A., Hoefer S., Horton L., Huijben J., Hutchinson P. J., Haberg A. K., Jacobs B., Jankowski S., Jarrett M., Jelaca B., Jiang J. -Y., Jones K., Kamnitsas K., Karan M., Katila A., Kaukonen M., Kerforne T., Kivisaari R., Kolias A. G., Kolumban B., Kolundzija K., Kondziella D., Koskinen L. -O., Kovacs N., Lagares A., Lanyon L., Laureys S., Lecky F., Ledig C., Lefering R., Legrand V., Lei J., Levi L., Lightfoot R., Lingsma H., Loeckx D., Lozano A., MacDonald S., Maegele M., Majdan M., Major S., Manara A., Manley G., Didier M., Martin L. F., Martino C., Maruenda A., Marechal H., Masala A., Mattern J., McFadyen C., McMahon C., Melegh B., Menovsky T., Morganti-Kossmann C., Mulazzi D., Muraleedharan V., Murray L., Muhlan H., Nair N., Negru A., Nelson D., Newcombe V., Nieboer D., Noirhomme Q., Nyiradi J., Oddo M., Oldenbeuving A., Oresic M., Ortolano F., Palotie A., Parizel P. M., Patruno A., Payen J. -F., Perera N., Perlbarg V., Persona P., Peul W., Piippo-Karjalainen A., Floury S. P., Pirinen M., Ples H., Poca M. A., Polinder S., Pomposo I., Posti J., Puybasset L., Radoi A., Ragauskas A., Raj R., Rambadagalla M., Real R., Rehorcikova V., Rhodes J., Ripatti S., Rocka S., Roe C., Roise O., Roks G., Rosand J., Rosenfeld J., Rosenlund C., Rosenthal G., Rossaint R., Rossi S., Rueckert D., Rusnak M., Sacchi M., Sahakian B., Sahuquillo J., Sakowitz O., Sala F., Sanchez-Porras R., Sandor J., Santos E., Sasu L., Savo D., Schaffer N., Schipper I., Schlosser B., Schmidt S., Schoechl H., Schoonman G., Schou R. F., Schwendenwein E., Scholl M., Sir O., Skandsen T., Smakman L., Smeets D., Smielewski P., Sorinola A., Stamatakis E., Stanworth S., Steinbuchel N., Stevanovic A., Stevens R., Stewart W., Steyerberg E. W., Sundstrom N., Synnot A., Taccone F. S., Takala R., Tamas V., Tanskanen P., Taylor M. S., Te Ao B., Tenovuo O., Telgmann R., Teodorani G., Theadom A., Thomas M., Tibboel D., Tolias C., Tshibanda J. -F. L., Trapani T., Tudora C. M., Vajkoczy P., Vallance S., Valeinis E., Van Der Steen G., Van Der Naalt J., Van Essen T. A., Van Hecke W., Van Heugten C., Van Praag D., Vyvere T. V., Van Waesberghe J., Vanhaudenhuyse A., Vargiolu A., Vega E., Velt K., Verheyden J., Vespa P. M., Vik A., Vilcinis R., Vizzino G., Vleggeert-Lankamp C., Volovici V., Voormolen D., Vulekovic P., Vamos Z., Wade D., Wang K. K. W., Wang L., Wessels L., Wildschut E., Williams G., Wilson L., Winkler M. K. 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R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, RS: FPN NPPP I, Psychiatrie & Neuropsychologie, Menon, David [0000-0002-3228-9692], Ročka, Saulius, Molecular Neuroscience and Ageing Research (MOLAR), CENTER-TBI Investigators, van Veen, E, van der Jagt, M, Cnossen, M, Maas, A, de Beaufort, I, Menon, D, Citerio, G, Stocchetti, N, Rietdijk, W, van Dijck, J, and Kompanje, E

Subjects
Neurology, Internationality, Traumatic/complications, brain death, ethics, postmortem organ donation, traumatic brain injury, ventricular drainage, withdrawing life-sustaining measures, GUIDELINES, Critical Care and Intensive Care Medicine, 0302 clinical medicine, Traumatic brain injury, Trauma Centers, WORLDWIDE, Surveys and Questionnaires, Brain Injuries, Traumatic, Response rate (survey), Brain death, VDP::Medical disciplines: 700::Clinical medical disciplines: 750, VDP::Medisinske Fag: 700::Klinisk medisinske fag: 750, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Tissue and Organ Procurement/legislation & jurisprudence, POLICIES, Europe, VARIABILITY, Neurosurgery, Clinical evaluation, medicine.medical_specialty, Tissue and Organ Procurement, Withdrawing life-sustaining measure, Other Research Radboud Institute for Molecular Life Sciences [Radboudumc 0], Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18], 03 medical and health sciences, Neurological assessment, medicine, Humans, Organ donation, Ethics, Postmortem organ donation, Ventricular drainage, Withdrawing life-sustaining measures, Ethic, business.industry, Research, Brain Injuries, Traumatic/complications, 3112 Neurosciences, 030208 emergency & critical care medicine, ADULTS, lcsh:RC86-88.9, Traumatic brain injury, Brain death, Ethics, Postmortem organ donation, Withdrawing life-sustaining measures, Ventricular drainage, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Reconstructive and regenerative medicine Radboud Institute for Health Sciences [Radboudumc 10], Trauma Centers/organization & administration, Brain Injuries, Emergency medicine, Human medicine, business, 030217 neurology & neurosurgery, Regional differences
Abstract

Source at https://doi.org/10.1186/s13054-018-2241-4. Licensed CC BY-NC-ND 4.0. Background: We aimed to investigate the extent of the agreement on practices around brain death and postmortem organ donation. Methods: Investigators from 67 Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) study centers completed several questionnaires (response rate: 99%). Results: Regarding practices around brain death, we found agreement on the clinical evaluation (prerequisites and neurological assessment) for brain death determination (BDD) in 100% of the centers. However, ancillary tests were required for BDD in 64% of the centers. BDD for nondonor patients was deemed mandatory in 18% of the centers before withdrawing life-sustaining measures (LSM). Also, practices around postmortem organ donation varied. Organ donation after circulatory arrest was forbidden in 45% of the centers. When withdrawal of LSM was contemplated, in 67% of centers the patients with a ventricular drain in situ had this removed, either sometimes or all of the time. Conclusions: This study showed both agreement and some regional differences regarding practices around brain death and postmortem organ donation. We hope our results help quantify and understand potential differences, and provide impetus for current dialogs toward further harmonization of practices around brain death and postmortem organ donation.

Published
2018
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