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3 results on '"De Witte, Ko"'

1. Construction of a 1.2-Mb Sequence-Ready Contig of Chromosome 11q13 Encompassing the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene

Author

Lemmens, Irma, primary, Merregaert, Jozef, additional, Van de Ven, Wim J.M., additional, Kas, Koen, additional, Zhang, Chang X., additional, Giraud, Sophie, additional, Wautot, Virginie, additional, Buisson, Nathalie, additional, De Witte, Ko, additional, Salandre, Janine, additional, Lenoir, Gilbert, additional, Calender, Alain, additional, Parente, Fabienne, additional, Quincey, Danielle, additional, Courseaux, Anouk, additional, Carle, George F., additional, Gaudray, Patrick, additional, De Wit, Mireille J., additional, Lips, Cornelis J.M., additional, Höppener, Jo W.M., additional, Khodaei, Shideh, additional, Grant, Abby L., additional, Weber, Günther, additional, Kytölä, Soili, additional, Teh, Bin T., additional, Farnebo, Filip, additional, Grimmond, Sean, additional, Phelan, Catherine, additional, Larsson, Catharina, additional, Forbes, Simon A., additional, Bassett, J.H.Duncan, additional, Pannett, Anna A.J., additional, and Thakker, Rajesh V., additional

Published
1997
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2. Identification of the Multiple Endocrine Neoplasia Type 1 (MEN1) Gene.

Author

Lemmens, Irma, Van de Ven, Wim J. M., Kas, Koen, Zhang, Chang X., Giraud, Sophie, Wautot, Virginie, Buisson, Nathalie, De Witte, Ko, Salandre, Janine, Lenoir, Gilbert, Pugeat, Michel, Calender, Alain, Parente, Fabienne, Quincey, Danielle, Gaudray, Patrick, De Wit, Mireille J., Lips, Cornelis J. M., Höppener, Jo W. M., Khodaei, Shideh, and Grant, Abby L.

Published
1997
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3. Simplified Strategy for Detection of Recombinant Human Immunodeficiency Virus Type 1 Group M Isolates bygag/envHeteroduplex Mobility Assay

Author

Heyndrickx, Leo, Janssens, Wouter, Zekeng, Le´opold, Musonda, Rosemary, Anagonou, Se´verin, Van der Auwera, Gert, Coppens, Sandra, Vereecken, Katleen, De Witte, Ko, Van Rampelbergh, Rian, Kahindo, Maina, Morison, Linda, McCutchan, Francine E., Carr, Jean K., Albert, Jan, Essex, Max, Goudsmit, Jaap, Asjo¨, Birgitta, Salminen, Mika, Buve´, Anne, and van der Groen, Guido

Abstract

ABSTRACTWe developed a heteroduplex mobility assay in the gaggene (gagHMA) for the identification of group M subtypes A to H. The assay covers the region coding for amino acid 132 of p24 to amino acid 20 of p7 (according to human immunodeficiency virus type 1 [HIV-1] ELI, 460 bp). ThegagHMA was compared with sequencing and phylogenetic analysis of an evaluation panel of 79 HIV-1 group M isolates isolated from infected individuals from different geographic regions. Application of gagHMA in combination with envHMA on 252 HIV-1- positive plasma samples from Be´nin, Cameroon, Kenya, and Zambia revealed a high prevalence of a variety of intersubtype recombinants in Yaounde´, Cameroon (53.8%); Kisumu, Kenya (26.8%); and Cotonou, Be´nin (41%); no recombinants were identified among the samples from Ndola, Zambia. The AGIbNGcirculating recombinant form, as determined bygagHMA, was found to be the most common intersubtype recombinant in Yaounde´ (39.4%) and Cotonou (38.5%). Using a one-tube reverse transcriptase PCR protocol, this gagHMA in combination with envHMA is a useful tool for rapidly monitoring the prevalence of the various genetic subtypes as well as of recombinants of HIV-1. Moreover, this technology can easily be applied in laboratories in developing countries.

Published
2000
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