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13 results on '"De la Coba, Cristobal"'

3. Randomised clinical trial comparing sequential and concomitant therapies for Helicobacter pylori eradication in routine clinical practice

Author

McNicholl, Adrian G, Marin, Alicia C, Molina-Infante, Javier, Castro, Manuel, Barrio, Jesús, Ducons, Julio, Calvet, Xavier, de la Coba, Cristobal, Montoro, Miguel, Bory, Felipe, Perez-Aisa, Angeles, Forné, Montserrat, Gisbert, Javier P, Ramas, Mercedes, Millán, Raquel, Aranguren, Patxi, García-Iglesias, Pilar, Belloc, Blanca, Bessa, Xavier, Sainz, Empar, Gisbert, Jose-Luis, Lamas, Eloisa, Figuerola, Ariadna, Álvarez, Cristina, Marcos, Eusebio S, Moreno, Maria-Isabel, and Abad-Santos, Francisco

Published
2014
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4. European Registry on Helicobacter pylori Management: Effectiveness of First and Second-Line Treatment in Spain

Author

Caldas, Maria, Perez-Aisa, Angeles, Castro-Fernandez, Manuel, Bujanda, Luis, Lucendo, Alfredo J., Rodrigo, Luis, Huguet, Jose M., Perez-Lasala, Jorge, Molina-Infante, Javier, Barrio, Jesus, Fernandez-Salazar, Luis, Lanas, Angel, Perona, Monica, Dominguez-Cajal, Manuel, Ortuno, Juan, Gomez-Rodriguez, Blas Jose, Almela, Pedro, Botargues, Josep Maria, Nunez, Oscar, Modolell, Ines, Gomez, Judith, Ruiz-Zorrilla, Rafael, De la Coba, Cristobal, Huerta, Alain, Iyo, Eduardo, Pozzati, Liliana, Anton, Rosario, Barenys, Merce, Angueira, Teresa, Fernandez-Bermejo, Miguel, Campillo, Ana, Alcedo, Javier, Pajares-Villaroya, Ramon, Mego, Marianela, Bermejo, Fernando, Dominguez-Jimenez, Jose Luis, Tito, Llucia, Fernandez, Nuria, Pabon-Carrasco, Manuel, Cosme, Angel, Mata-Romero, Pilar, Alcaide, Noelia, Arino, Ines, Di Maira, Tommaso, Garre, Ana, Puig, Ignasi, Nyssen, Olga P., Megraud, Francis, O'Morain, Colm, Gisbert, Javier P., Hp EuReg Investigators, and UAM. Departamento de Medicina

Subjects
Microbiology (medical), second-line, Helicobacter pylori infection, medicine.medical_specialty, Multivariate analysis, Medicina, Therapeutics, Biochemistry, Microbiology, 03 medical and health sciences, 0302 clinical medicine, Antibiotic resistance, Moxifloxacin, Internal medicine, Medicine, Pharmacology (medical), General Pharmacology, Toxicology and Pharmaceutics, Medical prescription, first-line, Helicobacter pylori, Spain, first-line, second-line, treatment, Second line treatment, biology, Helicobacter pylori, treatment, business.industry, lcsh:RM1-950, Infeccions per Helicobacter pylori, biology.organism_classification, Terapèutica, Helicobacter pylori infections, bacterial infections and mycoses, Infectious Diseases, lcsh:Therapeutics. Pharmacology, Spain, 030220 oncology & carcinogenesis, Concomitant, 030211 gastroenterology & hepatology, business, medicine.drug
Abstract

The management of Helicobacter pylori infection has to rely on previous local effectiveness due to the geographical variability of antibiotic resistance. The aim of this study was to evaluate the effectiveness of first and second-line H. pylori treatment in Spain, where the empirical prescription is recommended. A multicentre prospective non-interventional registry of the clinical practice of European gastroenterologists concerning H. pylori infection (Hp-EuReg) was developed, including patients from 2013 until June 2019. Effectiveness was evaluated descriptively and through a multivariate analysis concerning age, gender, presence of ulcer, proton-pump inhibitor (PPI) dose, therapy duration and compliance. Overall, 53 Spanish hospitals were included, and 10,267 patients received a first-line therapy. The best results were obtained with the 10-day bismuth single-capsule therapy (95% cure rate by intention-to-treat) and with both the 14-day bismuth-clarithromycin quadruple (PPI-bismuth-clarithromycin-amoxicillin, 91%) and the 14-day non-bismuth quadruple concomitant (PPI-clarithromycin-amoxicillin-metronidazole, 92%) therapies. Second-line therapies were prescribed to 2448 patients, with most-effective therapies being the triple quinolone (PPI-amoxicillin-levofloxacin/moxifloxacin) and the bismuth-levofloxacin quadruple schemes (PPI-bismuth-levofloxacin-amoxicillin) prescribed for 14 days (92%, 89% and 90% effectiveness, respectively), and the bismuth single-capsule (10 days, 88.5%). Compliance, longer duration and higher acid inhibition were associated with higher effectiveness. &ldquo, Optimized&rdquo, H. pylori therapies achieve over 90% success in Spain.

Published
2021

5. Tu1335 European Registry on H. pylori Management (HP-EuReg) in Spain: Interim Analysis in First and Second Line Therapies

Author

Caldas, Maria, primary, Aisa, Angeles Perez, additional, Castro-Fernandez, Manuel, additional, Bujanda, Luis, additional, Rodrigo, Luis, additional, Hinojosa, J, additional, Perez-Lasala, Jorge, additional, Lanas, Angel, additional, Molina-Infante, Javier, additional, Domínguez-Cajal, Manuel, additional, Almela, Pedro, additional, Barrio, Jesús, additional, Botargues, Josep M., additional, Salazar, Luis Fernandez, additional, Modolell, Ines, additional, Lucendo, Alfredo J., additional, Ortuño, Juan, additional, Ruiz-Zorrilla, Rafael, additional, De la Coba, Cristobal, additional, Barenys, M, additional, Alcedo, J, additional, Perona, Monica C., additional, Gómez, J, additional, Bermejo, F, additional, Pajares, R., additional, Pozzati, Liliana, additional, Rodríguez-Téllez, Manuel, additional, Gomez-Rodriguez, Blas-Jose, additional, Medina, Enrique, additional, Huguet, José María, additional, Barceló, Luis Ferrer, additional, Ramas, Mercedes, additional, O'Morain, Colm A., additional, McNicholl, Adrian G., additional, and Gisbert, Javier P., additional

Published
2016
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6. Tu1107 Adalimumab Dose Escalation Is Effective for Managing Loss of Response in Ulcerative Colitis

Author

Taxonera, Carlos, primary, Flores, Eva Iglesias, additional, Muñoz, Fernando, additional, Calvo, Marta, additional, Barreiro-de Acosta, Manuel, additional, Busquets, David, additional, Calvet, Xavier, additional, Rodriguez, Antonio, additional, Pajares, R., additional, Gisbert, Javier P., additional, Lopez-Serrano, Pilar, additional, Pérez-Calle, José Lázaro, additional, Diaz, Angel Ponferrada, additional, De la Coba, Cristobal, additional, Bermejo, Fernando, additional, Chaparro, Maria, additional, Alba, Cristina, additional, Olivares, David, additional, and Fernández-Blanco, Ignacio, additional

Published
2015
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7. Accuracy of GastroPanel for the diagnosis of atrophic gastritis

Author

McNicholl, Adrian G., primary, Forné, Montserrat, additional, Barrio, Jesus, additional, De la Coba, Cristobal, additional, González, Begoña, additional, Rivera, Robin, additional, Esteve, Maria, additional, Fernandez-Bañares, Fernando, additional, Madrigal, Beatriz, additional, Gras-Miralles, Beatriz, additional, Perez-Aisa, Angeles, additional, Viver-Pi-Sunyer, Jose M., additional, Bory, Felipe, additional, Rosinach, Merce, additional, Loras, Carmen, additional, Esteban, Carlos, additional, Santolaria, Santos, additional, Gomollon, Fernando, additional, Valle, Julio, additional, and Gisbert, Javier P., additional

Published
2014
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8. Su1167 European Registry on H. pylori Management (Hp-EuReg): Spanish Detailed Results (Interim Analysis)

Author

Caldas, Maria, primary, McNicholl, Adrian G., additional, Molina-Infante, Javier, additional, Huerta, Alain, additional, Aisa, Angeles Perez, additional, Castro-Fernandez, Manuel, additional, Barrio, Jesus, additional, Montoro, Miguel A., additional, Cajal, Manuel Domínguez, additional, Lucendo, Alfredo J., additional, Lanas, Angel, additional, Ducons, Julio, additional, Modolell, Ines, additional, Salazar, Luis Fernandez, additional, Rodriguez, Blas J. Gómez, additional, Botargues, Josep M., additional, Barenys, Mercè, additional, De la Coba, Cristobal, additional, Rodrigo, Luis, additional, Millastre, Judith, additional, Almela, Pedro, additional, Alcedo, J., additional, Calvet, Xavier, additional, Sanchez-Pobre, Pilar, additional, Bujanda, Luis, additional, and Gisbert, Javier P., additional

Published
2014
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9. Sa1882 Phase IV, Prospective, Randomized and Comparative Study Between Sequential and Concomitant Therapy for Helicobacter pylori Eradication in Routine Clinical Practice

Author

McNicholl, Adrian G., primary, Marin, Alicia C, additional, Molina-Infante, Javier, additional, Castro-Fernandez, Manuel, additional, Barrio, Jesus, additional, Ducons, Julio, additional, Calvet, Xavier, additional, De la Coba, Cristobal, additional, Montoro, Miguel A., additional, Bory, Felipe, additional, Aisa, Angeles Perez, additional, Forné, Montserrat, additional, Ramas, Mercedes, additional, Millán, Raquel, additional, Aranguren, Patxi, additional, García-Iglesias, Pilar, additional, Belloc, Blanca, additional, Bessa, Xavier, additional, Sainz, Empar, additional, Lamas, Eloisa, additional, Figuerola, Ariadna, additional, Alvarez, Cristina, additional, Ruberte, Belén, additional, and Gisbert, Javier P., additional

Published
2013
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10. Su1705 Phase IV, Prospective, Randomized and Comparative Study Between Sequential and Concomitant Therapy for Helicobacter pylori Eradication in Routine Clinical Practice. Interim Results

Author

McNicholl, Adrian G., primary, Marin, Alicia C, additional, Molina-Infante, Javier, additional, Castro-Fernandez, Manuel, additional, Barrio, Jesus, additional, Ducons, Julio, additional, Calvet, Xavier, additional, De la Coba, Cristobal, additional, Montoro, Miguel A., additional, Bory, Felipe, additional, Aisa, Angeles Perez, additional, Forné-Bardera, Montse, additional, Ruberte, Belén, additional, Millan, Raquel, additional, Aranguren, Patxi, additional, Garcia-Iglesias, Pilar, additional, Belloc, Blanca, additional, Bessa, Xavier, additional, Sainz, Empar, additional, Marcos, Eusebio S., additional, Lamas, Eloisa, additional, Figuerola, Ariadna, additional, Alvarez, Cristina, additional, Gisbert, JoseLuis, additional, and Gisbert, Javier P., additional

Published
2012
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11. S1035 The Risk of Severe Crohn's Disease: Validation of a Clinical Prediction Rule

Author

Bastida, Guillermo, primary, Merino, Olga, additional, Aguas, Mariam, additional, Barreiro, Manuel, additional, Zabana, Yamile, additional, Ginard, Daniel, additional, Ceballos, Daniel, additional, Huguet, Jose María, additional, Muñoz, Fernando, additional, Garcia, Valle, additional, Catalán, Ignacio, additional, Lucendo, Alfredo J., additional, de la Coba, Cristobal, additional, Mante, Xavier Aldeguer, additional, Palau, Antonio, additional, and Loras, Carme, additional

Published
2009
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13. Bismuth quadruple regimen with tetracycline or doxycycline versus three-in-one single capsule as third-line rescue therapy for Helicobacter pylori infection: Spanish data of the European Helicobacter pylori Registry (Hp-EuReg).

Author

Nyssen OP, Perez-Aisa A, Rodrigo L, Castro M, Mata Romero P, Ortuño J, Barrio J, Huguet JM, Modollel I, Alcaide N, Lucendo A, Calvet X, Perona M, Gomez B, Gomez Rodriguez BJ, Varela P, Jimenez-Moreno M, Dominguez-Cajal M, Pozzati L, Burgos D, Bujanda L, Hinojosa J, Molina-Infante J, Di Maira T, Ferrer L, Fernández-Salazar L, Figuerola A, Tito L, de la Coba C, Gomez-Camarero J, Fernandez N, Caldas M, Garre A, Resina E, Puig I, O'Morain C, Megraud F, and Gisbert JP

Subjects
Adolescent, Adult, Aged, Aged, 80 and over, Anti-Bacterial Agents administration & dosage, Drug Combinations, Drug Therapy, Combination, Female, Helicobacter pylori drug effects, Humans, Male, Middle Aged, Prospective Studies, Proton Pump Inhibitors administration & dosage, Spain, Treatment Outcome, Young Adult, Bismuth administration & dosage, Doxycycline administration & dosage, Helicobacter Infections drug therapy, Metronidazole administration & dosage, Tetracycline administration & dosage
Abstract

Background: Different bismuth quadruple therapies containing proton-pump inhibitors, bismuth salts, metronidazole, and a tetracycline have been recommended as third-line Helicobacter pylori eradication treatment after failure with clarithromycin and levofloxacin., Aim: To evaluate the efficacy and safety of third-line treatments with bismuth, metronidazole, and either tetracycline or doxycycline., Methods: Sub-study with Spanish data of the "European Registry on H pylori Management" (Hp-EuReg), international multicenter prospective non-interventional Registry of the routine clinical practice of gastroenterologists. After previous failure with clarithromycin- and levofloxacin-containing therapies, patients receiving a third-line regimen with 10/14-day bismuth salts, metronidazole, and either tetracycline (BQT-Tet) or doxycycline (BQT-Dox), or single capsule (BQT-three-in-one) were included. Data were registered at AEG-REDCap database. Univariate and multivariate analyses were performed., Results: Four-hundred and fifty-four patients have been treated so far: 85 with BQT-Tet, 94 with BQT-Dox, and 275 with BQT-three-in-one. Average age was 53 years, 68% were women. Overall modified intention-to-treat and per-protocol eradication rates were 81% (BQT-Dox: 65%, BQT-Tet: 76%, BQT-three-in-one: 88%) and 82% (BQT-Dox: 66%, BQT-Tet: 77%, BQT-three-in-one: 88%), respectively. By logistic regression, higher eradication rates were associated with compliance (OR = 2.96; 95% CI = 1.01-8.84) and no prior metronidazole use (OR = 1.96; 95% CI = 1.15-3.33); BQT-three-in-one was superior to BQT-Dox (OR = 4.46; 95% CI = 2.51-8.27), and BQT-Tet was marginally superior to BQT-Dox (OR = 1.67; 95% CI = 0.85-3.29)., Conclusion: Third-line H pylori eradication with bismuth quadruple treatment (after failure with clarithromycin and levofloxacin) offers acceptable efficacy and safety. Highest efficacy was found in compliant patients and those taking 10-day BQT-three-in-one or 14-day BQT-Tet. Doxycycline seems to be less effective and therefore should not be recommended., (© 2020 John Wiley & Sons Ltd.)

Published
2020
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