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34 results on '"DeBay, Drew R."'

4. Contributors

Author

Alexiou, Athanasios, primary, Amenta, Francesco, additional, Amoroso, Nicola, additional, Andrews, Jessica L., additional, Arba, Francesco, additional, Armato, Ubaldo, additional, Ashraf, Ghulam Md, additional, Attardo, Lapo, additional, Avelino-Silva, Thiago Junqueira, additional, Ayres, Annelise, additional, Bagetta, Giacinto, additional, Balietti, Marta, additional, Battineni, Gopi, additional, Beheshti, Siamak, additional, Belbasis, Lazaros, additional, Bellou, Vanesa, additional, Bergantin, Leandro Bueno, additional, Berríos, Waleska, additional, Boccardi, Virginia, additional, Bosco, Andrea, additional, Briggs, Robert, additional, Burtscher, Johannes, additional, Burtscher, Martin, additional, Caffò, Alessandro O., additional, Cajas-Salazar, Nohelia, additional, Callisaya, Michele L., additional, Caricati-Neto, Afonso, additional, Carlesi, Cecilia, additional, Castillo-Ordoñez, Willian Orlando, additional, Chan, Victor T.T., additional, Chatzichronis, Stylianos, additional, Cheung, Carol Y., additional, Chiarini, Anna M., additional, Cipollini, Virginia, additional, Cipriani, Gabriele, additional, Claeysen, Sylvie, additional, Claffey, Paul, additional, Clarnette, Roger, additional, Corasaniti, Maria Tiziana, additional, Cornelis, Elise, additional, Dal Prà, Ilaria, additional, Darvesh, Sultan, additional, DeBay, Drew R., additional, Del Dotto, Paolo, additional, De Reuck, Jacques, additional, De Vriendt, Patricia, additional, Dharmadasa, Thanuja, additional, Dovey, Kathryn, additional, Downey, H. Fred, additional, Dyer, Adam H., additional, Eccher, Claudio, additional, Endres, Kristina, additional, Evangelou, Evangelos, additional, Fernandez, Francesca, additional, Fong Yan, Alycia, additional, Frith, Emily, additional, Garcez, Flavia Barreto, additional, Giannoni, Patrizia, additional, Giubilei, Franco, additional, Glazachev, Oleg S., additional, Glynn-Servedio, B.E., additional, Golimstok, Angel, additional, Gorus, Ellen, additional, Gottesman, Rebecca F., additional, Hatashita, Shizuo, additional, Holle, Bernhard, additional, Housseini, Mahboobeh, additional, Huynh, William, additional, Ienco, Elena Caldarazzo, additional, Ismeurt, Caroline, additional, Jayakody, Oshadi, additional, Kamalraj, Pabiththa, additional, Wolf-Ostermann, Karin, additional, Kawaguchi, Kazunori, additional, Kennelly, Sean P., additional, Kiernan, Matthew C., additional, King, Anna E., additional, Kitaguchi, Nobuya, additional, Kito, Shinsuke, additional, Laporte Uribe, Franziska, additional, Liu, Yue, additional, Lopez, Antonella, additional, Loprinzi, Paul D., additional, Low, Lee-Fay, additional, Mallet, Robert T., additional, Manukhina, Eugenia B., additional, Marucci, Gabriella, additional, Matias-Guiu, Jordi A., additional, Matthew Wai Kin, Wong, additional, Mecocci, Patrizia, additional, Molloy, D. William, additional, Monteleone, Domenico, additional, Morrone, Luigi Antonio, additional, Moruzzi, Michele, additional, Müller, Thomas, additional, Nady, Braidy, additional, Nunomura, Akihiko, additional, Nuti, Angelo, additional, O'Caoimh, Rónán, additional, O'Halloran, Paul, additional, Padovani, Marina, additional, Pallotta, Graziano, additional, Paolacci, Lucia, additional, Parker, Helen, additional, Perminder Singh, Sachdev, additional, Philippe, Couratier, additional, Poljak, Anne, additional, Raglio, Alfredo, additional, Rainero, Innocenzo, additional, Regan, Bridget, additional, Reid, Larry D., additional, Reinhardt, Sven, additional, René Thyrian, Jochen, additional, Rinnoci, Valentina, additional, Río-Sancho, Sergio del, additional, Rombolà, Laura, additional, Rozenfeld Olchik, Maira, additional, Rubino, Elisa, additional, Sakai, Kazuyoshi, additional, Sakurada, Tsukasa, additional, Sakurada, Shinobu, additional, Savundranayagam, Marie Y., additional, Scorza, Fúlvio Alexandre, additional, Scuteri, Damiana, additional, Serebrovskaya, Tatiana V., additional, Shigeta, Masahiro, additional, Shinagawa, Shunichiro, additional, Spano, Giuseppina, additional, Stuart, Kimberley E., additional, Tagai, Kenji, additional, Tamaoki, Toshio, additional, Taylor, Dylan Z., additional, Traini, Enea, additional, Troili, Fernanda, additional, Vacca, Alessandro, additional, Vickers, James C., additional, Walf, Alicia A., additional, Walker, Keenan A., additional, Wells, Yvonne, additional, Woltjer, Randall J., additional, and Wood, Paul L., additional

Published
2020
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25. P1-296: ALTERNATIVE CEREBRAL GLUCOSE UPTAKE METRICS DETECT EARLY METABOLIC CHANGES IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE

Author

DeBay, Drew R., primary, Macdonald, Ian R., additional, Reid, G. Andrew, additional, O'Leary, Tim P., additional, Jollymore, Courtney T., additional, Cash, Meghan K., additional, Mawko, George, additional, Burrell, Steven, additional, Martin, Earl, additional, Bowen, Chris V., additional, Brown, Richard E., additional, and Darvesh, Sultan, additional

Published
2014
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26. IC-P-098: ALTERNATIVE CEREBRAL GLUCOSE UPTAKE METRICS DETECT EARLY METABOLIC CHANGES IN THE 5XFAD MOUSE MODEL OF ALZHEIMER'S DISEASE

Author

DeBay, Drew R., primary, Macdonald, Ian R., additional, Reid, G. Andrew, additional, O'Leary, Tim P., additional, Jollymore, Courtney T., additional, Cash, Meghan K., additional, Mawko, George, additional, Burrell, Steve, additional, Martin, Earl, additional, Bowen, Chris V., additional, Brown, Richard E., additional, and Darvesh, Sultan, additional

Published
2014
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32. Combined PET/MR: Where Anatomical Imaging Meets Cellular Function.

Author

DeBay DR and Brewer KD

Subjects
Magnetic Resonance Imaging methods, Tomography, X-Ray Computed, Movement, Multimodal Imaging methods, Positron-Emission Tomography methods
Abstract

Recent technological advances in medical imaging have allowed for both sequential and simultaneous acquisition of magnetic resonance imaging (MRI) and positron emission tomography (PET) data. Simultaneous PET/MRI offers distinct advantages by efficiently capturing functional and metabolic processes with co-localized, high-resolution anatomical images while minimizing time and movement. We will describe some of the technical and logistic requirements for optimizing sequential and simultaneous PET/MRI in the preclinical research setting., (© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)

Published
2024
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33. Butyrylcholinesterase-knockout reduces fibrillar β-amyloid and conserves 18 FDG retention in 5XFAD mouse model of Alzheimer's disease.

Author

DeBay DR, Reid GA, Macdonald IR, Mawko G, Burrell S, Martin E, Bowen CV, and Darvesh S

Subjects
Alzheimer Disease diagnostic imaging, Alzheimer Disease genetics, Amyloid genetics, Amyloid beta-Peptides genetics, Amyloid beta-Protein Precursor genetics, Amyloid beta-Protein Precursor metabolism, Animals, Basal Ganglia metabolism, Brain metabolism, Butyrylcholinesterase genetics, Butyrylcholinesterase metabolism, Disease Models, Animal, Female, Gene Knockout Techniques, Glucose metabolism, Male, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Plaque, Amyloid metabolism, Positron-Emission Tomography methods, Radiopharmaceuticals pharmacokinetics, Alzheimer Disease metabolism, Amyloid metabolism, Amyloid beta-Peptides metabolism, Butyrylcholinesterase deficiency, Fluorodeoxyglucose F18 pharmacology
Abstract

Alzheimer's disease (AD) is the most common neurodegenerative disorder causing dementia. One hallmark of the AD brain is the deposition of β-amyloid (Aβ) plaques. AD is also a state of cholinergic dysfunction and butyrylcholinesterase (BChE) associates with Aβ pathology. A transgenic mouse (5XFAD) is an aggressive amyloidosis model, producing Aβ plaques with which BChE also associates. A derived strain (5XFAD/BChE-KO), with the BChE gene knocked out, has significantly lower fibrillar Aβ than 5XFAD mice at the same age. Therefore, BChE may have a role in Aβ pathogenesis. Furthermore, in AD, diminished glucose metabolism in the brain can be detected in vivo with positron emission tomography (PET) imaging following 2-deoxy-2-( 18 F)fluoro-D-glucose ( 18 FDG) administration. To determine whether hypometabolism is related to BChE-induced changes in fibrillar Aβ burden, whole brain and regional uptake of 18 FDG in 5XFAD and 5XFAD/BChE-KO mice was compared to corresponding wild-type (WT 5XFAD and WT BChE-KO ) strains at 5months. Diminished fibrillar Aβ burden was confirmed in 5XFAD/BChE-KO mice relative to 5XFAD. 5XFAD and 5XFAD/BChE-KO mice demonstrated reduction in whole brain 18 FDG retention compared to respective wild-types. Regional analysis of relevant AD structures revealed reduction in 18 FDG retention in 5XFAD mice in all brain regions analyzed (save cerebellum) compared to WT 5XFAD . Alternatively, 5XFAD/BChE-KO mice demonstrated a more selective pattern of reduced retention in the cerebral cortex and thalamus compared to WT BChE-KO , while retention in hippocampal formation, amygdala and basal ganglia remained unchanged. This suggests that in knocking out BChE and reducing fibrillar Aβ, a possible protective effect on brain function may be conferred in a number of structures in 5XFAD/BChE-KO mice., (Copyright © 2017 Elsevier B.V. All rights reserved.)

Published
2017
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34. Using MRI to evaluate and predict therapeutic success from depot-based cancer vaccines.

Author

DeBay DR, Brewer KD, LeBlanc SA, Weir GM, Stanford MM, Mansour M, and Bowen CV

Abstract

In the preclinical development of immunotherapy candidates, understanding the mechanism of action and determining biomarkers that accurately characterize the induced host immune responses is critical to improving their clinical interpretation. Magnetic resonance imaging (MRI) was used to evaluate in vivo changes in lymph node size in response to a peptide-based cancer vaccine therapy, formulated using DepoVax (DPX). DPX is a novel adjuvant lipid-in-oil-based formulation that facilitates enhanced immune responses by retaining antigens at the injection site for extended latencies, promoting increased potentiation of immune cells. C57BL/6 mice were implanted with C3 (HPV) tumor cells and received either DPX or control treatments, 5 days post-implantation. Complete tumor eradication occurred in DPX-vaccinated animals and large volumetric increases were observed in the vaccine-draining right inguinal lymph node (VRILN) in DPX mice, likely corresponding to increased localized immune response to the vaccine. Upon evaluating the relative measure of vaccine-potentiated immune activation to tumor-induced immune response (VRILN/VLILN), receiver-operating characteristic (ROC) curves revealed an area under the curve (AUC) of 0.90 (±0.07), indicating high specificity and sensitivity as a predictive biomarker of vaccine efficacy. We have determined that for this tumor model, early MRI lymph node volumetric changes are predictive of depot immunotherapeutic success.

Published
2015
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