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4. Learning ratio performance on a brief visual learning and memory test moderates cognitive training gains in Double Decision task in healthy older adults

Author

Hardcastle, Cheshire, Kraft, Jessica N., Hausman, Hanna K., O’Shea, Andrew, Albizu, Alejandro, Evangelista, Nicole D., Boutzoukas, Emanuel M., Van Etten, Emily J., Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., Porges, Eric, DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel S., Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., and Woods, Adam J.

Published
2024
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7. The impact of a tDCS and cognitive training intervention on task-based functional connectivity

Author

Kraft, Jessica N., Indahlastari, Aprinda, Boutzoukas, Emanuel M., Hausman, Hanna K., Hardcastle, Cheshire, Albizu, Alejandro, O’Shea, Andrew, Evangelista, Nicole D., Van Etten, Emily J., Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel, Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., Porges, Eric, and Woods, Adam J.

Published
2024
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12. Connecting memory and functional brain networks in older adults: a resting-state fMRI study

Author

Waner, Jori L., Hausman, Hanna K., Kraft, Jessica N., Hardcastle, Cheshire, Evangelista, Nicole D., O’Shea, Andrew, Albizu, Alejandro, Boutzoukas, Emanuel M., Van Etten, Emily J., Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel S., Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., Porges, Eric C., and Woods, Adam J.

Published
2023
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14. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease

Author

Ali, Muhammad, Archer, Derek B., Gorijala, Priyanka, Western, Daniel, Timsina, Jigyasha, Fernández, Maria V., Wang, Ting-Chen, Satizabal, Claudia L., Yang, Qiong, Beiser, Alexa S., Wang, Ruiqi, Chen, Gengsheng, Gordon, Brian, Benzinger, Tammie L. S., Xiong, Chengjie, Morris, John C., Bateman, Randall J., Karch, Celeste M., McDade, Eric, Goate, Alison, Seshadri, Sudha, Mayeux, Richard P., Sperling, Reisa A., Buckley, Rachel F., Johnson, Keith A., Won, Hong-Hee, Jung, Sang-Hyuk, Kim, Hang-Rai, Seo, Sang Won, Kim, Hee Jin, Mormino, Elizabeth, Laws, Simon M., Fan, Kang-Hsien, Kamboh, M. Ilyas, Vemuri, Prashanthi, Ramanan, Vijay K., Yang, Hyun-Sik, Wenzel, Allen, Rajula, Hema Sekhar Reddy, Mishra, Aniket, Dufouil, Carole, Debette, Stephanie, Lopez, Oscar L., DeKosky, Steven T., Tao, Feifei, Nagle, Michael W., Hohman, Timothy J., Sung, Yun Ju, Dumitrescu, Logan, and Cruchaga, Carlos

Published
2023
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21. Higher white matter hyperintensity load adversely affects pre-post proximal cognitive training performance in healthy older adults

Author

Boutzoukas, Emanuel M., O’Shea, Andrew, Kraft, Jessica N., Hardcastle, Cheshire, Evangelista, Nicole D., Hausman, Hanna K., Albizu, Alejandro, Van Etten, Emily J., Bharadwaj, Pradyumna K., Smith, Samantha G., Song, Hyun, Porges, Eric C., Hishaw, Alex, DeKosky, Steven T., Wu, Samuel S., Marsiske, Michael, Alexander, Gene E., Cohen, Ronald, and Woods, Adam J.

Published
2022
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22. Investigating Sepsis-Associated Delirium Through Optical Neuroimaging: A New Frontier in Critical Care Research.

Author

Jiang, Shixie, Gunther, Matthew, Maldonado, Jose R., Efron, Philip A., DeKosky, Steven T., and Jiang, Huabei

Subjects
OPTICAL spectroscopy, OPTICAL tomography, NEAR infrared spectroscopy, INTENSIVE care units, SPECTRAL imaging
Abstract

Sepsis is a life-threatening syndrome consisting of physiological, pathological, and biochemical abnormalities induced by infection which continues to be a major public health burden. It remains one of the most common reasons for intensive care unit (ICU) admission. Delirium precipitated by sepsis in the intensive care setting is one of its most common neuropsychiatric complications that leads to prolonged hospitalization, increased mortality, and an increased risk of incident dementia. Understanding the pathophysiology and neurobiological mechanisms of sepsis-associated delirium is difficult; neuroimaging biomarkers are lacking due to difficulties with imaging critically ill patients. Optical imaging techniques, including near-infrared spectroscopy and diffuse optical tomography are potentially promising approaches for investigating this pathophysiology due to their portability and high spatiotemporal resolution. In this review, we examine the emergence of optical neuroimaging techniques for the study of sepsis-associated delirium in the ICU and how they can further advance our knowledge and lead to the development of improved preventative, predictive, and therapeutic strategies. [ABSTRACT FROM AUTHOR]

Published
2024
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23. Glucagon‐Like Peptide‐1 Receptor Agonists and Risk of Parkinson's Disease in Patients with Type 2 Diabetes: A Population‐Based Cohort Study.

Author

Tang, Huilin, Lu, Ying, Okun, Michael S., Donahoo, William T., Ramirez‐Zamora, Adolfo, Wang, Fei, Huang, Yu, Armstrong, Melissa, Svensson, Mikael, Virnig, Beth A., DeKosky, Steven T., Bian, Jiang, and Guo, Jingchuan

Abstract

Background: Previous studies have suggested that glucagon‐like peptide‐1 receptor agonists (GLP‐1RAs) may have a disease‐modifying effect in the development of Parkinson's disease (PD), but population studies yielded inconsistent results. Objective: The aim was to compare the risk of PD associated with GLP‐1RAs compared to dipeptidyl peptidase 4 inhibitors (DPP4i) among older adults with type 2 diabetes (T2D). Methods: Using U.S. Medicare administrative data from 2016 to 2020, we conducted a population‐based cohort study comparing the new use of GLP‐1RA with the new use of DPP4i among adults aged ≥66 years with T2D. The primary endpoint was a new diagnosis of PD. A stabilized inverse probability of treatment weighting (sIPTW)–adjusted Cox proportional hazards regression model was employed to estimate the hazard ratio (HR) and 95% confidence intervals (CI) for PD between GLP‐1RA and DPP4i users. Results: This study included 89,074 Medicare beneficiaries who initiated either GLP‐1RA (n = 30,091) or DPP4i (n = 58,983). The crude incidence rate of PD was lower among GLP‐1RA users than DPP4i users (2.85 vs. 3.92 patients per 1000 person‐years). An sIPTW‐adjusted Cox model showed that GLP‐1RA users were associated with a 23% lower risk of PD than DPP4i users (HR, 0.77; 95% CI, 0.63–0.95). Our findings were largely consistent across different subgroup analyses such as sex, race, and molecular structure of GLP‐1RA. Conclusion: Among Medicare beneficiaries with T2D, the new use of GLP‐1RAs was significantly associated with a decreased risk of PD compared to the new use of DPP4i. © 2024 International Parkinson and Movement Disorder Society. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Proximal improvement and higher-order resting state network change after multidomain cognitive training intervention in healthy older adults

Author

Hardcastle, Cheshire, Hausman, Hanna K., Kraft, Jessica N., Albizu, Alejandro, O’Shea, Andrew, Boutzoukas, Emanuel M., Evangelista, Nicole D., Langer, Kailey, Van Etten, Emily J., Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., Porges, Eric, DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel S., Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., and Woods, Adam J.

Published
2022
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25. Cingulo-opercular and frontoparietal control network connectivity and executive functioning in older adults

Author

Hausman, Hanna K., Hardcastle, Cheshire, Albizu, Alejandro, Kraft, Jessica N., Evangelista, Nicole D., Boutzoukas, Emanuel M., Langer, Kailey, O’Shea, Andrew, Van Etten, Emily J., Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., Porges, Eric, DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel, Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., and Woods, Adam J.

Published
2022
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26. Higher-order resting state network association with the useful field of view task in older adults

Author

Hardcastle, Cheshire, Hausman, Hanna K., Kraft, Jessica N., Albizu, Alejandro, Evangelista, Nicole D., Boutzoukas, Emanuel M., O’Shea, Andrew, Langer, Kailey, Van Van Etten, Emily, Bharadwaj, Pradyumna K., Song, Hyun, Smith, Samantha G., Porges, Eric, DeKosky, Steven T., Hishaw, Georg A., Wu, Samuel S., Marsiske, Michael, Cohen, Ronald, Alexander, Gene E., and Woods, Adam J.

Published
2022
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27. Military-related risk factors for dementia

Author

Snyder, Heather M, Carare, Roxana O, DeKosky, Steven T, de Leon, Mony J, Dykxhoorn, Derek, Gan, Li, Gardner, Raquel, Hinds, Sidney R, Jaffee, Michael, Lamb, Bruce T, Landau, Susan, Manley, Geoff, McKee, Ann, Perl, Daniel, Schneider, Julie A, Weiner, Michael, Wellington, Cheryl, Yaffe, Kristine, Bain, Lisa, Pacifico, Anthony M, and Carrillo, Maria C

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Dementia, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Brain Disorders, Post-Traumatic Stress Disorder (PTSD), Prevention, Traumatic Brain Injury (TBI), Physical Injury - Accidents and Adverse Effects, Neurodegenerative, Traumatic Head and Spine Injury, Aging, Alzheimer's Disease, Acquired Cognitive Impairment, Neurological, Good Health and Well Being, Animals, Brain Injuries, Traumatic, Congresses as Topic, Humans, Military Personnel, Risk Factors, Veterans, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionIn recent years, there has been growing discussion to better understand the pathophysiological mechanisms of traumatic brain injury and post-traumatic stress disorder and how they may be linked to an increased risk of neurodegenerative diseases including Alzheimer's disease in veterans.MethodsBuilding on that discussion, and subsequent to a special issue of Alzheimer's & Dementia published in June 2014, which focused on military risk factors, the Alzheimer's Association convened a continued discussion of the scientific community on December 1, 2016.ResultsDuring this meeting, participants presented and evaluated progress made since 2012 and identified outstanding knowledge gaps regarding factors that may impact veterans' risk for later life dementia.DiscussionThe following is a summary of the invited presentations and moderated discussions of both the review of scientific understanding and identification of gaps to inform further investigations.

Published
2018

28. Recommendations for the nomenclature of cognitive change associated with anaesthesia and surgery—2018

Author

Evered, L, Silbert, B, Knopman, DS, Scott, DA, DeKosky, ST, Rasmussen, LS, Oh, ES, Crosby, G, Berger, M, Eckenhoff, RG, Group, The Nomenclature Consensus Working, Evered, Lisbeth, Eckenhoff, Roderic G, Ames, David, Bekker, Alex, Berger, Miles, Blacker, Deborah, Browndyke, Jeffrey, Crosby, Greg, Deiner, Stacie G, van Dijk, Diederik, DeKosky, Steven T, Eckenhoff, Maryellen F, Eriksson, Lars, Galasko, Dougas, Hogan, Kirk, Inouye, Sharon, Knopman, David, Lyketsos, Constantine, Marcantonio, Edward, Maruff, Paul, Maze, Mervyn, Oh, Esther, Orser, Beverley A, Ottens, Thomas, Price, Catherine, Rasmussen, Lars S, Sachdev, Perminder, Schenning, Katie, Scott, David A, Seiber, Frederick E, Silbert, Brendan, Silverstein, Jeff, Steinmetz, Jacob, Terrando, Niccolo, Trzapacz, Paula, Whittington, Rob, and Xie, Zhongcong

Subjects
Biomedical and Clinical Sciences, Clinical Sciences, Acquired Cognitive Impairment, Dementia, Mental Health, Behavioral and Social Science, Clinical Research, Brain Disorders, Aging, Neurosciences, Mental health, Anesthesia, Cognition Disorders, Diagnostic and Statistical Manual of Mental Disorders, Emergence Delirium, Humans, Incidence, Neuropsychological Tests, Postoperative Complications, Preexisting Condition Coverage, Research Design, Terminology as Topic, Nomenclature Consensus Working Group, cognition disorders, delirium, neurocognitive disorders, postoperative complications, Anesthesiology, Clinical sciences
Abstract

Cognitive change affecting patients after anaesthesia and surgery has been recognised for more than 100 yr. Research into cognitive change after anaesthesia and surgery accelerated in the 1980s when multiple studies utilised detailed neuropsychological testing for assessment of cognitive change after cardiac surgery. This body of work consistently documented decline in cognitive function in elderly patients after anaesthesia and surgery, and cognitive changes have been identified up to 7.5 yr afterwards. Importantly, other studies have identified that the incidence of cognitive change is similar after non-cardiac surgery. Other than the inclusion of non-surgical control groups to calculate postoperative cognitive dysfunction, research into these cognitive changes in the perioperative period has been undertaken in isolation from cognitive studies in the general population. The aim of this work is to develop similar terminology to that used in cognitive classifications of the general population for use in investigations of cognitive changes after anaesthesia and surgery. A multispecialty working group followed a modified Delphi procedure with no prespecified number of rounds comprised of three face-to-face meetings followed by online editing of draft versions. Two major classification guidelines [Diagnostic and Statistical Manual for Mental Disorders, fifth edition (DSM-5) and National Institute for Aging and the Alzheimer Association (NIA-AA)] are used outside of anaesthesia and surgery, and may be useful for inclusion of biomarkers in research. For clinical purposes, it is recommended to use the DSM-5 nomenclature. The working group recommends that 'perioperative neurocognitive disorders' be used as an overarching term for cognitive impairment identified in the preoperative or postoperative period. This includes cognitive decline diagnosed before operation (described as neurocognitive disorder); any form of acute event (postoperative delirium) and cognitive decline diagnosed up to 30 days after the procedure (delayed neurocognitive recovery) and up to 12 months (postoperative neurocognitive disorder).

Published
2018

30. Alzheimer’s Disease

Author

Shea, Yat-Fung, DeKosky, Steven T., Woods, Adam J., Section editor, Gu, Danan, editor, and Dupre, Matthew E., editor

Published
2021
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34. Transethnic genome‐wide scan identifies novel Alzheimer's disease loci

Author

Jun, Gyungah R, Chung, Jaeyoon, Mez, Jesse, Barber, Robert, Beecham, Gary W, Bennett, David A, Buxbaum, Joseph D, Byrd, Goldie S, Carrasquillo, Minerva M, Crane, Paul K, Cruchaga, Carlos, De Jager, Philip, Ertekin‐Taner, Nilufer, Evans, Denis, Fallin, M Danielle, Foroud, Tatiana M, Friedland, Robert P, Goate, Alison M, Graff‐Radford, Neill R, Hendrie, Hugh, Hall, Kathleen S, Hamilton‐Nelson, Kara L, Inzelberg, Rivka, Kamboh, M Ilyas, Kauwe, John SK, Kukull, Walter A, Kunkle, Brian W, Kuwano, Ryozo, Larson, Eric B, Logue, Mark W, Manly, Jennifer J, Martin, Eden R, Montine, Thomas J, Mukherjee, Shubhabrata, Naj, Adam, Reiman, Eric M, Reitz, Christiane, Sherva, Richard, St. George‐Hyslop, Peter H, Thornton, Timothy, Younkin, Steven G, Vardarajan, Badri N, Wang, Li‐San, Wendlund, Jens R, Winslow, Ashley R, Adams, Perrie M, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Asthana, Sanjay, Atwood, Craig S, Barmada, Michjael M, Barnes, Lisa L, Beach, Thomas G, Becker, James T, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Cairns, Nigel J, Cao, Chuanhai, Carlson, Chris S, Carlsson, Cynthia M, Carney, Regina M, Carroll, Steven L, Chui, Helena C, Clark, David G, Corneveaux, Jason, Cribbs, David H, Crocco, Elizabeth A, De Jager, Philip L, DeCarli, Charles, DeKosky, Steven T, Demirci, F Yesim, Dick, Malcolm, Dickson, Dennis W, Doody, Rachelle S, Duara, Ranjan, Faber, Kelley M, Fairchild, Thomas J, Fallon, Kenneth B, Farlow, Martin R, Ferris, Steven, Frosch, Matthew P, Galasko, Douglas R, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Glass, Jonathan D, Green, Robert C, and Growdon, John H

Subjects
Biomedical and Clinical Sciences, Biological Psychology, Clinical Sciences, Neurosciences, Psychology, Neurodegenerative, Genetics, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Acquired Cognitive Impairment, Aging, Human Genome, Prevention, Dementia, Alzheimer's Disease, Biotechnology, Brain Disorders, 2.1 Biological and endogenous factors, Adaptor Proteins, Signal Transducing, Alzheimer Disease, Apolipoprotein E4, GTPase-Activating Proteins, Genetic Predisposition to Disease, Genome-Wide Association Study, Heparin-binding EGF-like Growth Factor, Humans, Membrane Glycoproteins, Molecular Chaperones, NFI Transcription Factors, Peroxisomal Bifunctional Enzyme, Polymorphism, Single Nucleotide, Receptors, GABA, Alzheimer's Disease Genetics Consortium, APOE interaction, Alzheimer's disease, Genome-wide association, Transethnic, Geriatrics, Clinical sciences, Biological psychology
Abstract

IntroductionGenetic loci for Alzheimer's disease (AD) have been identified in whites of European ancestry, but the genetic architecture of AD among other populations is less understood.MethodsWe conducted a transethnic genome-wide association study (GWAS) for late-onset AD in Stage 1 sample including whites of European Ancestry, African-Americans, Japanese, and Israeli-Arabs assembled by the Alzheimer's Disease Genetics Consortium. Suggestive results from Stage 1 from novel loci were followed up using summarized results in the International Genomics Alzheimer's Project GWAS dataset.ResultsGenome-wide significant (GWS) associations in single-nucleotide polymorphism (SNP)-based tests (P

Published
2017

35. Brain and blood biomarkers of tauopathy and neuronal injury in humans and rats with neurobehavioral syndromes following blast exposure

Author

Dickstein, Dara L., De Gasperi, Rita, Gama Sosa, Miguel A., Perez-Garcia, Georgina, Short, Jennifer A., Sosa, Heidi, Perez, Gissel M., Tschiffely, Anna E., Dams-O’Connor, Kristen, Pullman, Mariel Y., Knesaurek, Karin, Knutsen, Andrew, Pham, Dzung L., Soleimani, Lale, Jordan, Barry D., Gordon, Wayne A., Delman, Bradley N., Shumyatsky, Gleb, Shahim, Pashtun-Poh, DeKosky, Steven T., Stone, James R., Peskind, Elaine, Blennow, Kaj, Zetterberg, Henrik, Chance, Steven A., Torso, Mario, Kostakoglu, Lale, Sano, Mary, Hof, Patrick R., Ahlers, Stephen T., Gandy, Sam, and Elder, Gregory A.

Published
2021
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36. Heterogeneous treatment effects of sodium‐glucose cotransporter 2 inhibitors on risk of dementia in people with type 2 diabetes: A population‐based cohort study.

Author

Tang, Huilin, Donahoo, William T., Svensson, Mikael, Shaaban, C. Elizabeth, Smith, Glenn, Jaffee, Michael S., Huang, Yu, Hu, Xia, Lu, Ying, Salloum, Ramzi G., DeKosky, Steven T., Bian, Jiang, and Guo, Jingchuan

Abstract

INTRODUCTION: Sodium‐glucose cotransporter 2 (SGLT2) inhibitors exhibit potential benefits in reducing dementia risk, yet the optimal beneficiary subgroups remain uncertain. METHODS: Individuals with type 2 diabetes (T2D) initiating either SGLT2 inhibitor or sulfonylurea were identified from OneFlorida+ Clinical Research Network (2016–2022). A doubly robust learning was deployed to estimate risk difference (RD) and 95% confidence interval (CI) of all‐cause dementia. RESULTS: Among 35,458 individuals with T2D, 1.8% in the SGLT2 inhibitor group and 4.7% in the sulfonylurea group developed all‐cause dementia over a 3.2‐year follow‐up, yielding a lower risk for SGLT2 inhibitors (RD, –2.5%; 95% CI, –3.0% to –2.1%). Hispanic ethnicity and chronic kidney disease were identified as the two important variables to define four subgroups in which RD ranged from –4.3% (–5.5 to –3.2) to –0.9% (–1.9 to 0.2). DISCUSSION: Compared to sulfonylureas, SGLT2 inhibitors were associated with a reduced risk of all‐cause dementia, but the association varied among different subgroups. Highlights: New users of sodium‐glucose cotransporter 2 (SGLT2) inhibitors were significantly associated with a lower risk of all‐cause dementia as compared to those of sulfonylureas.The association varied among different subgroups defined by Hispanic ethnicity and chronic kidney disease.A significantly lower risk of Alzheimer's disease and vascular dementia was observed among new users of SGLT2 inhibitors compared to those of sulfonylureas. [ABSTRACT FROM AUTHOR]

Published
2024
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37. Clinical and Adverse Outcomes Associated With Concomitant Use of CYP2D6-Metabolized Opioids With Antidepressants in Older Nursing Home Residents: A Target Trial Emulation Study.

Author

Wei, Yu-Jung Jenny, Winterstein, Almut G., Schmidt, Siegfried, Fillingim, Roger B., Daniels, Michael J., DeKosky, Steven T., and Schmidt, Stephan

Subjects
NURSING home residents, EMERGENCY room visits, OPIOID abuse, DRUG interactions, CYTOCHROME P-450
Abstract

The nature of pharmacokinetic interactions between cytochrome P450 (CYP) 2D6 (CYP2D6)-metabolized opioids and antidepressants among older nursing home residents is unclear. In this study of nursing home residents, concomitant use of CYP2D6-metabolized opioids with CYP2D6-inhibiting antidepressants was associated with higher adjusted rate ratios of worsening pain, pain-related hospitalization, pain-related emergency department visits, and opiate use disorder. These findings suggest the need for caution in prescribing these agents in older patients. Visual Abstract. Clinical and Adverse Outcomes Associated With Concomitant Use of CYP2D6-Metabolized Opioids With Antidepressants in Older Nursing Home Residents: The nature of pharmacokinetic interactions between cytochrome P450 (CYP) 2D6 (CYP2D6)-metabolized opioids and antidepressants among older nursing home residents is unclear. In this study of nursing home residents, concomitant use of CYP2D6-metabolized opioids with CYP2D6-inhibiting antidepressants was associated with higher adjusted rate ratios of worsening pain, pain-related hospitalization, pain-related emergency department visits, and opiate use disorder. These findings suggest the need for caution in prescribing these agents in older patients. Background: Limited evidence exists on the safety of pharmacokinetic interactions of cytochrome P450 (CYP) 2D6 (CYP2D6)-metabolized opioids with antidepressants among older nursing home (NH) residents. Objective: To investigate the associations of concomitant use of CYP2D6-metabolized opioids and antidepressants with clinical outcomes and opioid-related adverse events (ORAEs). Design: Retrospective cohort study using a target trial emulation framework. Setting: 100% Medicare NH sample linked to Minimum Data Set (MDS) from 2010 to 2021. Participants: Long-term residents aged 65 years and older receiving CYP2D6-metabolized opioids with a disease indication for antidepressant use. Intervention: Initiating CYP2D6-inhibiting versus CYP2D6-neutral antidepressants that overlapped with use of CYP2D6-metabolized opioids for 1 day or more. Measurements: Clinical outcomes were worsening pain, physical function, and depression from baseline to quarterly MDS assessments and were analyzed using modified Poisson regression models. The ORAE outcomes included counts of pain-related hospitalizations and emergency department (ED) visits, opioid use disorder (OUD), and opioid overdose and were analyzed with negative binomial or Poisson regression models. All models were adjusted for baseline covariates via inverse probability of treatment weighting. Results: Among 29 435 identified residents, use of CYP2D6-metabolized opioids concomitantly with CYP2D6-inhibiting (vs. CYP2D6-neutral) antidepressants was associated with a higher adjusted rate ratio of worsening pain (1.13 [95% CI, 1.09 to 1.17]) and higher adjusted incidence rate ratios of pain-related hospitalization (1.37 [CI, 1.19 to 1.59]), pain-related ED visit (1.49 [CI, 1.24 to 1.80]), and OUD (1.93 [CI, 1.37 to 2.73]), with no difference in physical function, depression, and opioid overdose. Limitation: Findings are generalizable to NH populations only. Conclusion: Use of CYP2D6-metabolized opioids concomitantly with CYP2D6-inhibiting (vs. CYP2D6-neutral) antidepressants was associated with worsening pain and increased risk for most assessed ORAEs among older NH residents. Primary Funding Source: National Institute on Aging. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Rarity of the Alzheimer Disease-Protective APP A673T Variant in the United States

Author

Wang, Li-San, Naj, Adam C, Graham, Robert R, Crane, Paul K, Kunkle, Brian W, Cruchaga, Carlos, Murcia, Josue D. Gonzalez, Cannon-Albright, Lisa, Baldwin, Clinton T, Zetterberg, Henrik, Blennow, Kaj, Kukull, Walter A, Faber, Kelley M, Schupf, Nicole, Norton, Maria C, Tschanz, JoAnn T, Munger, Ronald G, Corcoran, Christopher D, Rogaeva, Ekaterina, Lin, Chiao-Feng, Dombroski, Beth A, Cantwell, Laura B, Partch, Amanda, Valladares, Otto, Hakonarson, Hakon, St George-Hyslop, Peter, Green, Robert C, Goate, Alison M, Foroud, Tatiana M, Carney, Regina M, Larson, Eric B, Behrens, Timothy W, Kauwe, John S. K, Haines, Jonathan L, Farrer, Lindsay A, Pericak-Vance, Margaret A, Mayeux, Richard, Schellenberg, Gerard D, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Barber, Robert, Barmada, M. Michael, Barnes, Lisa L, Beach, Thomas G, Becker, James T, Beecham, Gary W, Beekly, Duane, Bennett, David A, Bigio, Eileen H, Bird, Thomas D, Blacker, Deborah, Boeve, Bradley F, Bowen, James D, Boxer, Adam, Burke, James R, Buxbaum, Joseph D, Cairns, Nigel J, Cao, Chuanhai, Carlson, Chris S, Carroll, Steven L, Chui, Helena C, Clark, David G, Cribbs, David H, Crocco, Elizabeth A, DeCarli, Charles, DeKosky, Steven T, Demirci, F. Yesim, Dick, Malcolm, Dickson, Dennis W, Duara, Ranjan, Ertekin-Taner, Nilufer, Fallon, Kenneth B, Farlow, Martin R, Ferris, Steven, Frosch, Matthew P, Galasko, Douglas R, Ganguli, Mary, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Glass, Jonathan D, Graff-Radford, Neill R, Growdon, John H, Hamilton, Ronald L, Hamilton-Nelson, Kara L, Harrell, Lindy E, Head, Elizabeth, Honig, Lawrence S, Hulette, Christine M, Hyman, Bradley T, Jarvik, Gail P, Jicha, Gregory A, Jin, Lee-Way, Jun, Gyungah, Kamboh, M. Ilyas, Karydas, Anna, and Kaye, Jeffrey A

Published
2015

50. Effects of Multiple Genetic Loci on Age at Onset in Late-Onset Alzheimer Disease

Author

Naj, Adam C, Jun, Gyungah, Reitz, Christiane, Kunkle, Brian W, Perry, William, Park, Yo Son, Beecham, Gary W, Rajbhandary, Ruchita A, Hamilton-Nelson, Kara L, Wang, Li-San, Kauwe, John S. K, Huentelman, Matthew J, Myers, Amanda J, Bird, Thomas D, Boeve, Bradley F, Baldwin, Clinton T, Jarvik, Gail P, Crane, Paul K, Rogaeva, Ekaterina, Barmada, M. Michael, Demirci, F. Yesim, Cruchaga, Carlos, Kramer, Patricia L, Ertekin-Taner, Nilufer, Hardy, John, Graff-Radford, Neill R, Green, Robert C, Larson, Eric B, St. George-Hyslop, Peter H, Buxbaum, Joseph D, Evans, Denis A, Schneider, Julie A, Lunetta, Kathryn L, Kamboh, M. Ilyas, Saykin, Andrew J, Reiman, Eric M, De Jager, Philip L, Bennett, David A, Morris, John C, Montine, Thomas J, Goate, Alison M, Blacker, Deborah, Tsuang, Debby W, Hakonarson, Hakon, Kukull, Walter A, Foroud, Tatiana M, Martin, Eden R, Haines, Jonathan L, Mayeux, Richard P, Farrer, Lindsay A, Schellenberg, Gerard D, Pericak-Vance, Margaret A, Albert, Marilyn S, Albin, Roger L, Apostolova, Liana G, Arnold, Steven E, Barber, Robert, Barnes, Lisa L, Beach, Thomas G, Becker, James T, Beekly, Duane, Bigio, Eileen H, Bowen, James D, Boxer, Adam, Burke, James R, Cairns, Nigel J, Cantwell, Laura B, Cao, Chuanhai, Carlson, Chris S, Carney, Regina M, Carrasquillo, Minerva M, Carroll, Steven L, Chui, Helena C, Clark, David G, Corneveaux, Jason, Cribbs, David H, Crocco, Elizabeth A, DeCarli, Charles, DeKosky, Steven T, Dick, Malcolm, Dickson, Dennis W, Duara, Ranjan, Faber, Kelley M, Fallon, Kenneth B, Farlow, Martin R, Ferris, Steven, Frosch, Matthew P, Galasko, Douglas R, Ganguli, Mary, Gearing, Marla, Geschwind, Daniel H, Ghetti, Bernardino, Gilbert, John R, Glass, Jonathan D, Growdon, John H, Hamilton, Ronald L, Harrell, Lindy E, Head, Elizabeth, Honig, Lawrence S, and Hulette, Christine M

Published
2014

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