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18 results on '"DeWyer, Alyssa"'

1. Refining Risk Stratification Among Children With Latent Rheumatic Heart Disease

Author

Beaton, Andrea, Okello, Emmy, Rwebembera, Joselyn, Grobler, Anneke, Engelman, Daniel, Alepere, Juliet, Carapetis, Jonathan, DeWyer, Alyssa, Lwabi, Peter, Mirabel, Mariana, Mocumbi, Ana Olga, Nakitto, Miriam, Ndagire, Emma, Nunes, Maria Carmo P., Omara, Isaac Otim, Sarnacki, Rachel, Scheel, Amy, Wilson, Nigel, Zühlke, Liesl, Karthikeyan, Ganesan, Sable, Craig A., and Steer, Andrew C.

Published
2023
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2. Abstract 15349: Factors Associated With Progression of Latent Rheumatic Heart Disease

Author

Beaton, Andrea Z, Okello, Emmy, Rwebembera, Joselyn, Engelman, Daniel, Carapetis, Jonathan, DEWYER, ALYSSA, Fall, Ndate, Lwabi, Peter, Mirabel, Mariana, Mocumbi, Ana O, nakitto, miriam, Ndagire, Emma, Nunes, Maria D, Pulle, Jafesi, Omara, Isaac, Sarnacki, Rachel, Scheel, Amy, Wilson, Nigel, Zimmerman, Meghan, Zuhlke, Liesl, Karthikeyan, Ganesan, Sable, Craig A, Grobler, Anneke, and Steer, Andrew

Published
2022
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3. Prevalence of group A β-hemolytic streptococcal throat carriage and prospective pilot surveillance of streptococcal sore throat in Ugandan school children

Author

DeWyer, Alyssa, Scheel, Amy, Webel, Allison R., Longenecker, Chris T., Kamarembo, Jennipher, Aliku, Twalib, Engel, Mark E., Bowen, Asha C., Bwanga, Freddie, Hovis, Ian, Chang, Aileen, Sarnacki, Rachel, Sable, Craig, Dale, James B., Carapetis, Jonathan, Rwebembera, Joselyn, Okello, Emmy, and Beaton, Andrea

Published
2020
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7. Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Rwebembera, Joselyn, additional, Grobler, Anneke, additional, Engelman, Daniel, additional, Alepere, Juliet, additional, Canales, Lesley, additional, Carapetis, Jonathan, additional, DeWyer, Alyssa, additional, Lwabi, Peter, additional, Mirabel, Mariana, additional, Mocumbi, Ana O., additional, Murali, Meghna, additional, Nakitto, Miriam, additional, Ndagire, Emma, additional, Nunes, Maria C.P., additional, Omara, Isaac O., additional, Sarnacki, Rachel, additional, Scheel, Amy, additional, Wilson, Nigel, additional, Zimmerman, Meghan, additional, Zühlke, Liesl, additional, Karthikeyan, Ganesan, additional, Sable, Craig A., additional, and Steer, Andrew C., additional

Published
2022
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8. Abstract 12503: A Randomized Controlled Trial of Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease

Author

Beaton, Andrea Z, primary, Okello, Emmy, additional, Rwebembera, Joselyn, additional, Grobler, Anneke, additional, Engelman, Daniel, additional, Carapetis, Jonathan, additional, Canales, Lesley, additional, DEWYER, ALYSSA, additional, Lwabi, Peter, additional, Mirabel, Mariana, additional, Mocumbi, Ana O, additional, Murali, Meghna, additional, nakitto, miriam, additional, Ndagire, Emma, additional, Nunes, Maria, additional, Omara, Isaac, additional, Sarnacki, Rachel, additional, Scheel, Amy, additional, Wilson, Nigel, additional, Zimmerman, Meghan, additional, Zuhlke, Liesl, additional, Karthikeyan, Ganesan, additional, Sable, Craig A, additional, and Steer, Andrew, additional

Published
2021
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9. Establishment of a cardiac telehealth program to support cardiovascular diagnosis and care in a remote, resource-poor setting in Uganda

Author

DeWyer, Alyssa, primary, Scheel, Amy, additional, Kamarembo, Jenipher, additional, Akech, Rose, additional, Asiimwe, Allan, additional, Beaton, Andrea, additional, Bobson, Bua, additional, Canales, Lesley, additional, DeStigter, Kristen, additional, Kazi, Dhruv S., additional, Kwan, Gene F., additional, Longenecker, Chris T., additional, Lwabi, Peter, additional, Murali, Meghna, additional, Ndagire, Emma, additional, Namuyonga, Judith, additional, Sarnacki, Rachel, additional, Ssinabulya, Isaac, additional, Okello, Emmy, additional, Aliku, Twalib, additional, and Sable, Craig, additional

Published
2021
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12. Determining the impact of Benzathine penicillin G prophylaxis in children with latent rheumatic heart disease (GOAL trial): Study protocol for a randomized controlled trial

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Engelman, Daniel, additional, Grobler, Anneke, additional, Scheel, Amy, additional, DeWyer, Alyssa, additional, Sarnacki, Rachel, additional, Omara, Isaac Otim, additional, Rwebembera, Joselyn, additional, Sable, Craig, additional, and Steer, Andrew, additional

Published
2019
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13. Improving the accuracy of heart failure diagnosis in low-resource settings through task sharing and decentralization

Author

DeWyer, Alyssa, primary, Scheel, Amy, additional, Otim, Isaac Omara, additional, Longenecker, Christopher T., additional, Okello, Emmy, additional, Ssinabulya, Isaac, additional, Morris, Stephen, additional, Okwir, Mark, additional, Oyang, William, additional, Joyce, Erine, additional, Nabongo, Betty, additional, Sable, Craig, additional, Alencherry, Ben, additional, Tompsett, Alison, additional, Aliku, Twalib, additional, and Beaton, Andrea, additional

Published
2019
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14. Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting

Author

Beaton, Andrea, primary, Okello, Emmy, additional, Scheel, Amy, additional, DeWyer, Alyssa, additional, Ssembatya, Renny, additional, Baaka, Olivia, additional, Namisanvu, Henrietor, additional, Njeri, Angela, additional, Matovu, Alphons, additional, Namagembe, Imelda, additional, Mccarter, Robert, additional, Carapetis, Jonathan, additional, DeStigter, Kristen, additional, and Sable, Craig, additional

Published
2018
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15. Community study to uncover the full spectrum of rheumatic heart disease in Uganda

Author

Scheel, Amy, primary, Ssinabulya, Isaac, additional, Aliku, Twalib, additional, Bradley-Hewitt, Tyler, additional, Clauss, Alexa, additional, Clauss, Sarah, additional, Crawford, Lexi, additional, DeWyer, Alyssa, additional, Donofrio, Mary T, additional, Jacobs, Marni, additional, Klein, Jennifer, additional, Moore, Teresa E, additional, Okello, Emmy, additional, Scheel, Janet, additional, Shaw, Rebekah, additional, Sable, Craig, additional, Lwabi, Peter, additional, Watkins, David A, additional, and Beaton, Andrea, additional

Published
2018
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16. Impact of heart disease on maternal, fetal and neonatal outcomes in a low-resource setting.

Author

Beaton, Andrea, Okello, Emmy, Scheel, Amy, DeWyer, Alyssa, Ssembatya, Renny, Baaka, Olivia, Namisanvu, Henrietor, Njeri, Angela, Matovu, Alphons, Namagembe, Imelda, Mccarter, Robert, Carapetis, Jonathan, Destigter, Kristen, and Sable, Craig

Subjects
NEONATAL mortality, HEART diseases, RHEUMATIC heart disease, FETAL diseases, HEART disease related mortality, PRENATAL care, LOW-income countries
Abstract

Background: The burden of pre-existing cardiovascular disease and the contribution to adverse pregnancy outcomes are not robustly quantified, particularly in low-income countries. We aimed to determine both the prevalence of maternal heart disease through active case finding and its attributable risk to adverse pregnancy outcomes.Methods: We conducted a 24-month prospective longitudinal investigation in three Ugandan health centres, using echocardiography for active case finding during antenatal care. Women with and without heart disease were followed to 6 weeks post partum to determine pregnancy outcomes. Prevalence of heart disease was calculated. Per cent attributable risk estimates were generated for maternal, fetal and neonatal mortality.Results: Screening echocardiography was performed in 3506 women. The prevalence of heart disease was 17 per 1000 women (95% CI 13 to 21); 15 per 1000 was rheumatic heart disease. Only 3.4% of women (2/58) had prior diagnosis. Cardiovascular complications occurred in 51% of women with heart disease, most commonly heart failure. Per cent attributable risk of heart disease on maternal mortality was 88.6% in the exposed population and 10.8% in the overall population. Population attributable risk of heart disease on fetal death was 1.1% and 6.0% for neonatal mortality CONCLUSIONS: Occult maternal heart disease may be responsible for a substantial proportion of adverse pregnancy outcomes in low-resource settings. Rheumatic heart disease is, by far, the most common condition, urging global prioritisation of this neglected cardiovascular disease. [ABSTRACT FROM AUTHOR]

Published
2019
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17. Community study to uncover the full spectrum of rheumatic heart disease in Uganda.

Author

Scheel, Amy, Ssinabulya, Isaac, Aliku, Twalib, Bradley-Hewitt, Tyler, Clauss, Alexa, Clauss, Sarah, Crawford, Lexi, DeWyer, Alyssa, Donofrio, Mary T., Jacobs, Marni, Klein, Jennifer, Moore, Teresa E., Okello, Emmy, Scheel, Janet, Shaw, Rebekah, Sable, Craig, Lwabi, Peter, Watkins, David A., and Beaton, Andrea

Subjects
RHEUMATIC heart disease, RHEUMATISM, RHEUMATIC fever, AORTIC valve insufficiency, MITRAL valve insufficiency
Published
2019
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18. Abstract 15544: Determining the Risk of Developing Rheumatic Heart Disease Following a Negative Screening Echocardiogram

Author

Zimmerman, Meghan, Scheel, Amy, Dewyer, Alyssa, Okello, Emmy, Sable, Craig A, and beaton, Andrea Z

Abstract

Introduction:Active case detection using screening echocardiography (echo) has high sensitivity for rheumatic heart disease (RHD). Most children with echo-detected RHD have mild disease, offering a chance to limit progression through secondary prophylaxis. However, implementation of screening programs in RHD endemic areas presents challenges given limited resources. Timing of screening remains an unexplored question. Here, we begin to address screening intervals by assessing risk of RHD among previous screen-negative children in Northern Uganda.Methods:Between June and October 2018, a large school-based echo screening was conducted in Gulu, Uganda and surrounding districts. Prior echo screenings had occurred in the same region in 2013 and 2014. A short 4-question interview was conducted, allowing children to self-identify as having prior screening. All children who self-reported were verified by checking the class and school they reported attending at the prior screening. Additionally, a subset (33%) of the sample was manually cross-checked by name, age, school and grade, to ensure adequacy of recall. Relative risk of RHD was calculated for those with a prior negative screening compared to those undergoing first screening.Results:Echo screening was completed in 102,400 children with 1,608 reporting a previous screening (44-61 months prior). Of the 528 children manually cross-checked, all were confirmed to have participated in a prior program. RHD was diagnosed in 1,099 children (1.1%), 10 (10/1608, 0.6%) of whom were previously screen-negative. The relative risk of RHD in children who have had a negative screening echo compared to those who were never previously screened was 0.58 (95% CI 0.3-1).Conclusions:Children who have a screen-negative echo have a low likelihood of developing RHD over a 4-5 year timeframe. While not reaching significance, prior screen-negative children in our cohort had a nearly 50% lower risk of RHD, indicating a strategy focused on a single screening may be practical. While verification is needed with larger sample sizes, these data provide the first information about a child?s risk of RHD following a negative echo screen and add to the growing implementation literature around this public health approach.

Published
2019
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