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2 results on '"Deborah S Jacob"'

1. Contact lenses in dry eye disease and associated ocular surface disorders

Author

Simmy Chaudhary, Deepak Ghimire, Sayan Basu, Vinay Agrawal, Deborah S Jacobs, and Swapna S Shanbhag

Subjects
aqueous deficiency dry eye, bandage contact lens, contact lens, dry eye disease, graft-versus-host disease, ocular chemical burns, ocular surface disease, scleral lens, stevens–johnson syndrome, Ophthalmology, RE1-994
Abstract

Dry eye disease (DED) is prevalent in all age groups and is known to cause chronic ocular discomfort and pain, and greatly affects the quality of life. Patients with ocular surface disease (OSD) may also have reduced tear secretion due to lacrimal gland damage, thus leading to aqueous deficient DED. Even with conventional management modalities such as lubricating eyedrops, topical corticosteroids, autologous serum eyedrops, or punctal plugs, many patients continue to suffer from debilitating symptoms. Contact lenses are increasingly being used in OSD providing surface hydration, protection from environmental insults, mechanical damage from abnormal lids, and as a modality for constant drug delivery to the ocular surface. This review describes the role of soft lenses and rigid gas-permeable scleral lenses in the management of DED associated with OSD. The efficacy of contact lenses, lens selection, and optimal lens fit are reviewed for specific indications.

Published
2023
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2. Effects of high-dose cancer chemotherapy on the absorption of digoxin in two different formulations

Author

Robert H. Christenson, Andrew T. Huang, Deborah S Jacob, Thorir D. Bjornsson, and Patricia A. Roth

Subjects
Adult, Male, Digoxin, medicine.medical_treatment, Radioimmunoassay, Administration, Oral, Biological Availability, Antineoplastic Agents, Capsules, Pharmacology, Drug Administration Schedule, Dosage form, Absorption, Random Allocation, Pharmacokinetics, Neoplasms, Humans, Medicine, Pharmacology (medical), Adverse effect, Chemotherapy, business.industry, Cancer, Middle Aged, Drug interaction, medicine.disease, Radiation therapy, Kinetics, Female, business, Tablets, medicine.drug
Abstract

The oral absorption of digoxin in tablet form has been reported to be reduced after cancer chemotherapy and radiation therapy because of cancer treatment-induced damage to the intestinal epithelium. We investigated possible differences in the effects of high-dose cancer chemotherapy on the relative bioavailability of digoxin administered in tablet form (Lanoxin; Burroughs Wellcome Co.) and in solution-in-capsule form (Lanoxicaps; Burroughs Wellcome Co.). Each subject received a single oral dose of either 0.5 mg Lanoxin (six subjects) or 0.4 mg Lanoxicaps (seven subjects) both before and after chemotherapy. For Lanoxin, there was a significant reduction in the AUC after chemotherapy to 54.4% +/- 35.5% (mean +/- SD) of the value before chemotherapy (P = 0.02), whereas for Lanoxicaps there was an insignificant reduction in AUC to 85.1% +/- 42.7% of the value before chemotherapy. These findings show that changes in the oral dosage formulation of digoxin from a tablet to a solution-in-capsule form can overcome the adverse effects of high-dose cancer chemotherapy on drug absorption, and suggest a similar approach may be successful for other drugs.

Published
1986
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