Search

Sepsis is a severe generalised infection caused usually by pathogenic bacteria. It is often the cause of hospitalization and death in patients treated in intensive care and other hospital wards. Latest research brought to better understanding of patomechanisms, took place significant development of therapy heading to improvement of general patients condition treated as a basis and additionally supported by local therapy. The aim of the study was to evaluate the possibility of using the solution Decasan in the comprehensive treatment of patients necrosis of soft tissues., Material and Methods: The study included 192 patients (W/M 103/89; average -aged 53.35 ± 5.36 years). According to the classification of septic states (Chicago, 1991), patients were divided into three groups: first - patients to the local form of the infection, the second - with Systemic Inflammatory Response Syndrome (SIRS), which lasted up to 72 hours and the third - patients with various forms of sepsis, SIRS in which lasted 72 hours., Results: As a result of our studies carried out in patients where the wound was made decontamination solution Decasanu, received: pain reduction, decrease tissue swelling, early debridement of the wound and the appearance in the wound granulation, to reduce delays wound healing. Proposed algorithms treatment of various forms of sepsis, pointed out the essential elements, ie.: a comprehensive approach to the treatment of infection by early surgical intervention, intensive supportive therapy (fluid resuscitation), antibiotic therapy directed to microorganisms that cause infections and topical antiseptics therapy (solution Decasanu)., Conclusions: The preparation antiseptic Decasan can be safely used for disinfection of skin, mucous membranes and wounds in the foci of infections caused by bacteria, fungi and protozoa.

Etiology of infective complications was investigated in 71 injured persons, suffering severe burns. There was established, that the main causing agents in patients, suffering burn disease, are S. aureus(in 35.9% of observations), A. baumannii (in 25%), P. aeruginosa (in 12.82%), P. mirabilis (in 5.12%). Resistance of conditionally pathogenic microorganisms towards cephalosporins, аminoglycosides, іmipenem, meropenem, doxycycline was determined. Effective bactericidal activity of antiseptic solutions of decasan, miramistinum, chlorhexidine was proved. High antimicrobial properties of dressing materials, which contain decametoxine, chlorhexidine, furagin, silver ions against Staphylococcus were noted. Clinical efficacy of application of materials, impregnated by antimicrobial composition decametoxine with carboxymethylstarch, oxyethylcellulose and polyvynilacetate, for prophylaxis and treatment of infective purulent—inflammatory complications in patients, suffering burns, was proved.

Experience of treatment of 17 patients, suffering cholangitis of various genesis, using antiseptic Decasan, is presented. Clinical efficacy of the preparation in complex treatment of cholangitis, confirmed by results of the bile bacteriological investigation, was noted.

Experience in treatment of 91 patients with peritonitis on various genesis using antiseptic Dekasan are presented. A marked clinical efficacy compared with that of other antiseptics in the complex treatment of peritonitis was noted.

The results of studying of antiseptic preparation Decasan for the treatment of patients, suffering purulent infections of pararectal region, are adduced. Efficacy of Decasan was analyzed in 102 patients. The results of investigation obtained are trusting hig antiseptic efficacy of preparation, witnessing possibility of its application as a preparation of choice for the treatment of patients, suffering purulent infections of pararectal region.

The experience of the use of domestic antiseptic dekasan for topical use in patients over the infected pancreatic necrosis and its complications. There was significant improvement in the results of patients treatment.

Experience in local application of antiseptic Dekasan in the complex treatment of abdominal infections of various origins are presented. The clinical and economic efficacy of the drug application is notice.

The results of complex treatment of 37 patients operated on for the various acute abdominal surgical diseases were presented. Among them 22 patients for locally treated 0.02% antiseptical solution Decametoxin were used. Positively impact clinical course of the diseases reducing their purulent and septic morbidity rate in particular were evidenced separately in the patients operated on for acute necrotic pancreatitis.

The authors discuss the results of complex treatment of 286 patients with acute pyoinflammatory diseases of the fingers and hand with the use of a new Soviet-produced antiseptic decametoxin. Panaris was diagnosed in 196 (68.5%), phlegmons and abscesses in 82 (29.7%), furuncle in 6 (2.1%) and carbuncle in 2 (0.7%) patients. 224 (78.4%) patients received out-patient and 62 (21.6%) in-patient treatment. The authors established that as the result of the applied complex treatment with the use of various antiseptic compositions containing decametoxin the mean duration of treatment was 7.8 days. The article discusses the causes of the disease, the methods of operative treatment, and management of patients in the postoperative period.

In the work based on the analysis of observation of 154 sufferers with an open craniocerebral trauma, the positive therapeutic and preventive action of agueous solutions of decamethoxine is shown.

Resulting from disease-prevention work among population of the district, use of BF-6D glue for treatment of microtraumas to skin of the hands, the number of patients with inflammatory diseases reduced by 14.7%.

The therapeutic and prophylactic effectiveness of gentamicin, decamethoxin and prodigiozan was determined on albino mice infected with two-fold lethal doses of the antibiotic-resistant strain of Ps. aeruginosa. Correlation between the effectiveness of the drug and the dose and time of its administration was found. Pronounced prophylactic and therapeutic effect of gentamicin in combination with decamethoxin was noted. Prodigiozan, a bacterial polysaccharide had no significant effect on the experimental pyocyanic infection of albino mice.