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3 results on '"Deepa, Raut"'

1. Differential expression of genes influencing mitotic processes in cord blood mononuclear cells after a pre-conceptional micronutrient-based randomised controlled trial: Pune Rural Intervention in Young Adolescents (PRIYA)

Author

Satyajeet P. Khare, Ayush Madhok, Indumathi Patta, Krishna K. Sukla, Vipul V. Wagh, Pooja S. Kunte, Deepa Raut, Dattatray Bhat, Kalyanaraman Kumaran, Caroline Fall, Utpal Tatu, Giriraj R. Chandak, Chittaranjan S. Yajnik, and Sanjeev Galande

Subjects
Medicine (miscellaneous)
Abstract

In The Pune Maternal Nutrition Study, vitamin B12 deficiency was seen in 65% of pregnant women, folate deficiency was rare. Maternal total homocysteine concentrations were inversely associated with offspring birthweight, and low vitamin B12 and high folate concentrations predicted higher offspring adiposity and insulin resistance. These findings guided a nested pre-conceptional randomised controlled trial ‘Pune Rural Intervention in Young Adolescents’. The interventions included: (1) vitamin B12+multi-micronutrients as per the United Nations International Multiple Micronutrient Antenatal Preparation, and proteins (B12+MMN), (2) vitamin B12 (B12 alone), and (3) placebo. Intervention improved maternal pre-conceptional and in-pregnancy micronutrient nutrition. Gene expression analysis in cord blood mononuclear cells in 88 pregnancies revealed 75 differentially expressed genes between the B12+MMN and placebo groups. The enriched biological processes included G2/M phase transition, chromosome segregation, and nuclear division. Enriched pathways included, mitotic spindle checkpoint and DNA damage response while enriched human phenotypes were sloping forehead and decreased head circumference. Fructose-bisphosphatase 2 (FBP2) and Cell Division Cycle Associated 2 (CDCA2) genes were under-expressed in the B12 alone group. The latter, involved in chromosome segregation was under-expressed in both intervention groups. Based on the role of B-complex vitamins in the synthesis of nucleotides and S-adenosyl methionine, and the roles of vitamins A and D on gene expression, we propose that the multi-micronutrient intervention epigenetically affected cell cycle dynamics. Neonates in the B12+MMN group had the highest ponderal index. Follow-up studies will reveal if the intervention and the altered biological processes influence offspring diabesity.

Published
2023
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2. A physiological dose of oral vitamin B-12 improves hematological, biochemical-metabolic indices and peripheral nerve function in B-12 deficient Indian adolescent women.

Author

Chittaranjan S Yajnik, Rishikesh V Behere, Dattatray S Bhat, Nilam Memane, Deepa Raut, Rasika Ladkat, Pallavi C Yajnik, Kalyanaraman Kumaran, and Caroline H D Fall

Subjects
Medicine, Science
Abstract

BackgroundVitamin B-12 deficiency is often considered synonymous with pernicious anemia, a rare condition in which severe malabsorption of the vitamin requires high-dose parenteral treatment. In developing countries such as India, inadequate dietary intake of B-12 due to socio-cultural factors leads to widely prevalent asymptomatic low B-12 status. In this scenario, lower doses of oral B-12 may be effective, safer and more affordable.ObjectiveTo examine the effects of oral B-12 treatment at physiological doses on hematological and biochemical indices and peripheral nerve function in B-12 deficient rural Indian adolescent women.MethodsThirty-nine women with B-12 deficiency who were excluded from a community based B-12 supplementation trial (Pune Rural Intervention in Young Adolescents (PRIYA)) received oral B-12 2μg/day, either alone (n = 19) or with multiple micronutrients (UNIMAPP formula + 20gm milk powder, n = 20) for 11 months. Hematological indices, nutrients (B-12, folate), metabolites (homocysteine) and peripheral nerve function (SUDOSCAN, Impetomedical, Paris and sensory nerve conduction velocity (NCV) of median and sural nerves) were assessed at baseline and after 11 months of B-12 treatment.ResultsResults were similar in the two treatment allocation groups, which were therefore combined. At baseline, all women had B-12 concentration ConclusionWe document clinically beneficial effects of supplementation with a physiological dose of oral B-12 in asymptomatic rural Indian adolescent women with very low B-12 status. These findings support a public health approach to tackle the widely prevalent low B-12 status in young Indians.

Published
2019
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3. Efficacy of B

Author

Chittaranjan, Yajnik, Sonal, Kasture, Vaishali, Kantikar, Himangi, Lubree, Dattatray, Bhat, Deepa, Raut, Nilam, Memane, Aboli, Bhalerao, Rasika, Ladkat, Pallavi, Yajnik, Sudhir, Tomar, Tejas, Limaye, and Sanat, Phatak

Subjects
Adult, Vitamin B 12, Folic Acid, Adolescent, Double-Blind Method, Food, Fortified, Humans, Female, Micronutrients, Child, Yogurt
Abstract

Dietary vitamin BTo study efficacy of BTwo double-blind, placebo-controlled directly observed therapy randomized controlled trials were conducted for 120 days: (1) Healthy children (10-13 years) were fed nutrient bar fortified with BWe randomized 164 children and 118 adults; adherence was 96% and 82%, respectively. In children, BB

Published
2021

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