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430 results on '"Dees C"'

1. OP0166 SKIN RETICULARIZATION IN SYSTEMIC SCLEROSIS - POTENTIAL MEDIATORS

Author

Chenguiti Fakhouri, S., primary, Zhu, H., additional, Ronicke, M., additional, Dees, C., additional, Konstantinidis, L., additional, Rius Rigau, A., additional, Matei, A. E., additional, LI, Y. N., additional, Eckstein, M., additional, Geppert, C., additional, Ludolph, I., additional, Kreuter, A., additional, Sticherling, M., additional, Berking, C., additional, Schett, G., additional, Horch, R., additional, Distler, J., additional, and Bergmann, C., additional

Published
2024
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3. OP0320 EFFICACY OF CD19-TARGETING CAR T CELL TREATMENT IN PATIENTS WITH DIFFUSE SYSTEMIC SCLEROSIS (dSSc) – AN OPEN LABEL, SINGLE-CENTER PILOT STUDY

Author

Auth, J., primary, Müller, F., additional, Taubmann, J., additional, Völkl, S., additional, Chenguiti Fakhouri, S., additional, Bucci, L., additional, Aigner, M., additional, Atzinger, A., additional, Bayerl, N., additional, Wirsching, A., additional, Dees, C., additional, Raimondo, M. G., additional, Tur, C., additional, Distler, J., additional, Mackensen, A., additional, Schett, G., additional, and Bergmann, C., additional

Published
2024
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4. Disturbed spatial activation of WNT/beta-catenin signaling in Systemic Sclerosis

Author

Bergmann, C, Chenguiti Fakhouri, S, Konstantinidis, L, Zhu, H, Rigaz, A, Györfi, AH, Eckstein, M, Geppert, CI, Dees, C, Kreuter, A, Sticherling, M, Schett, G, Distler, J, Bergmann, C, Chenguiti Fakhouri, S, Konstantinidis, L, Zhu, H, Rigaz, A, Györfi, AH, Eckstein, M, Geppert, CI, Dees, C, Kreuter, A, Sticherling, M, Schett, G, and Distler, J

Published
2023

6. 204P Phase Ib study of gedatolisib plus palbociclib and endocrine therapy in women with hormone receptor positive advanced breast cancer: Updated results in treatment naïve patients

Author

Rugo, H.S., primary, Wesolowski, R., additional, Stringer-Reasor, E., additional, Han, H., additional, Specht, J., additional, Dees, C., additional, Kabos, P., additional, Vaishampayan, U.N., additional, Wander, S.A., additional, Lu, J., additional, Gogineni, K., additional, Spira, A., additional, Schott, A., additional, Abu-Khalaf, M., additional, Mutka, S., additional, Suzuki, S., additional, Gorbatchevsky, I., additional, and Layman, R.M., additional

Published
2023
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13. POS0328 ENGRAILED 1 COORDINATES CYTOSKELETAL ORGANIZATION TO PROMOTE MYOFIBROBLAST DIFFERENTIATION AND FIBROTIC TISSUE REMODELING

Author

Györfi, A. H., primary, Matei, A. E., additional, Fuchs, M., additional, Rius Rigau, A., additional, Hong, X., additional, Honglin, Z., additional, Luber, M., additional, Bergmann, C., additional, Dees, C., additional, Ludolph, I., additional, Horch, R., additional, Distler, O., additional, Schett, G., additional, Kunz, M., additional, and Distler, J. H. W., additional

Published
2021
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14. OP0272 68GA-FAPI-04 PET/CT STUDY EXTENSION FOR THE ASSESSMENT OF FIBROBLAST ACTIVATION AND RISK EVALUATION IN SYSTEMIC SCLEROSIS-RELATED INTERSTITIAL LUNG DISEASE

Author

Bergmann, C., primary, Distler, J. H. W., additional, Treutlein, C., additional, Tascilar, K., additional, Mueller, A. T., additional, Atzinger, A., additional, Matei, A. E., additional, Knitza, J., additional, Györfi, A. H., additional, Lueck, A., additional, Dees, C., additional, Soare, A., additional, Ramming, A., additional, Schönau, V., additional, Distler, O., additional, Prante, O., additional, Ritt, P., additional, Goetz, T. I., additional, Koehner, M., additional, Cordes, M., additional, Baeuerle, T., additional, Kuwert, T., additional, Schett, G., additional, and Schmidkonz, C., additional

Published
2021
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16. S.6.1 β-catenin is a central mediator in SSc

Author

Distler, A., Palumbo, K., Dees, C., Bergmann, C., Venalis, P., Zerr, P., Horn, A., Beyer, C., MacDougald, O. A., Distler, O., Schett, G., and Distler, J. H. W.

Published
2012

18. OP0142 FIBROBLAST GROWTH FACTOR RECEPTOR 3 REGULATES THE ACTIVITY OF PROFIBROTIC CYTOKINE AND GROWTH FACTOR PATHWAYS TO DRIVE FIBROBLAST ACTIVATION AND TISSUE FIBROSIS IN SYSTEMIC SCLEROSIS

Author

Chakraborty, D., primary, Zhu, H., additional, Juengel, A., additional, Summa, L., additional, LI, Y. N., additional, Bergmann, C., additional, Matei, A. E., additional, Trinh-Minh, T., additional, Chen, C. W., additional, Dees, C., additional, Ramming, A., additional, Schett, G., additional, Distler, O., additional, and Distler, J., additional

Published
2020
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24. Final edition

Author

Dees, C. Stanley

Subjects
United States. Department of Defense -- Powers and duties, United States. General Services Administration -- Powers and duties, United States. National Aeronautics and Space Administration -- Powers and duties, Public contracts -- Laws, regulations and rules, Government purchasing -- Laws, regulations and rules, Government contract, Government regulation, Business, Business, general, Federal Acquisition Streamlining Act of 1994
Published
2006

25. Final edition

Author

Dees, C. Stanley

Subjects
United States. Small Business Administration -- Laws, regulations and rules, United States. House of Representatives -- Laws, regulations and rules, Small business -- Laws, regulations and rules -- United States, Home-based businesses -- Laws, regulations and rules, Government regulation, Small business, SOHO, Business, general, Business
Abstract

Legislation Bills Regarding Contract Consolidation Requirements for Small Businesses Introduced in Senate and House Senator Olympia Snowe has introduced a bill, titled the 'Small Business Administration 50th Anniversary Reauthorization Act [...]

Published
2003

28. PU.1 controls fibroblast polarization and tissue fibrosis

Author

Wohlfahrt, T, Rauber, S, Uebe, S, Luber, M, Soare, A, Ekici, A, Weber, S, Matei, A-E, Chen, C-W, Maier, C, Karouzakis, E, Kiener, HP, Pachera, E, Dees, C, Beyer, C, Daniel, C, Gelse, K, Kremer, AE, Naschberger, E, Stuerzl, M, Butter, F, Sticherling, M, Finotto, S, Kreuter, A, Kaplan, MH, Jungel, A, Gay, S, Nutt, SL, Boykin, DW, Poon, GMK, Distler, O, Schett, G, Distler, JHW, Ramming, A, Wohlfahrt, T, Rauber, S, Uebe, S, Luber, M, Soare, A, Ekici, A, Weber, S, Matei, A-E, Chen, C-W, Maier, C, Karouzakis, E, Kiener, HP, Pachera, E, Dees, C, Beyer, C, Daniel, C, Gelse, K, Kremer, AE, Naschberger, E, Stuerzl, M, Butter, F, Sticherling, M, Finotto, S, Kreuter, A, Kaplan, MH, Jungel, A, Gay, S, Nutt, SL, Boykin, DW, Poon, GMK, Distler, O, Schett, G, Distler, JHW, and Ramming, A

Abstract

Fibroblasts are polymorphic cells with pleiotropic roles in organ morphogenesis, tissue homeostasis and immune responses. In fibrotic diseases, fibroblasts synthesize abundant amounts of extracellular matrix, which induces scarring and organ failure. By contrast, a hallmark feature of fibroblasts in arthritis is degradation of the extracellular matrix because of the release of metalloproteinases and degrading enzymes, and subsequent tissue destruction. The mechanisms that drive these functionally opposing pro-fibrotic and pro-inflammatory phenotypes of fibroblasts remain unknown. Here we identify the transcription factor PU.1 as an essential regulator of the pro-fibrotic gene expression program. The interplay between transcriptional and post-transcriptional mechanisms that normally control the expression of PU.1 expression is perturbed in various fibrotic diseases, resulting in the upregulation of PU.1, induction of fibrosis-associated gene sets and a phenotypic switch in extracellular matrix-producing pro-fibrotic fibroblasts. By contrast, pharmacological and genetic inactivation of PU.1 disrupts the fibrotic network and enables reprogramming of fibrotic fibroblasts into resting fibroblasts, leading to regression of fibrosis in several organs.

Published
2019

29. S.6.1 β-catenin is a central mediator in SSc

Author

Beyer, C., Schramm, A., Distler, A., Dees, C., Taketo, M. M., de Crombrugghe, B., Distler, O., Schett, G., Distler, J. H. W., Tomcik, M., Palumbo, K., Akhmetshina, A., Horn, A., Zerr, P., Bergmann, C., Venalis, P., MacDougald, O. A., Lagares, D., Busnadiego, O., Garcia-Fernandez, R., Kapoor, M., Liu, S., Carter, D., Abraham, D., Shi-Wen, X., Carreira, P., Fontaine, B., Shea, B., Tager, A., Leask, A., Lamas, S., and Rodriguez-Pascual, F.

Subjects
integumentary system
Abstract

Background. β-catenin is the central integrator of canonical Wnt signalling. Since recent evidence suggests a central role of Wnts in fibrosis, we examined the β-catenin/Wnt pathway in SSc and focused on the role of β-catenin in fibroblast activation. Methods. We performed qPCR for several Wnt ligands and axin-2 to examine Wnt expression in SSc skin. We further studied protein levels of Wnt-1, -4, -10b and β-catenin by IHC. To establish the effects of β-catenin/Wnt signalling on collagen release, we created mice with fibroblast-specific stabilization of β-catenin (dEx3 β-catenin (wt/fl) × Col1a2; Cre-ER) as well as mice carrying fibroblast-specific deletion of β-catenin [Ctnnb1(fl/fl) × Col1a2; Cre-ER]. Summary of the results. We could demonstrate mRNA overexpression of Wnt-1, -2, -9a, -9b, -10a, -10b and -16 in SSc skin. Wnt-1, -4 and -10b consistently showed strong expression in SSc skin when compared with healthy skin. On protein level, however, Wnt-4 was indistinguishable between SSc patients and healthy controls, whereas Wnt-1 and Wnt-10b protein levels were increased in SSc skin. The overexpression of Wnt-1 and Wnt-10b resulted in a prominent nuclear accumulation of β-catenin in fibroblasts. Finally, increased mRNA levels of the target gene axin-2 confirmed the activation of canonical Wnt signalling. In dEx3 β-catenin (wt/ex) mice, we addressed the consequences of enhanced Wnt signalling and increased accumulation of β-catenin in SSc. We selectively targeted β-catenin in fibroblasts. Cre-activated dEx3 β-catenin (wt/fl) × Col1a2; Cre-ER mice showed massive and spontaneous dermal thickening even 2 weeks after Cre activation. Eight weeks after Cre-activation, skin thickening cumulated at 102.6% (P < 0.001). In line with the dermal thickening, hydroxyproline content and myofibroblast counts showed strong increases. To test the therapeutic potential of targeting β-catenin/Wnt signaling, we created Ctnnb1(fl/fl) x Col1a2;Cre-ER mice to specifically delete β-catenin in fibroblasts. After Cre activation and β-catenin deletion in fibroblasts, mice were challenged with bleomycin subcutaneously for 4 weeks. We found that Cre-activated Ctnnb1(fl/fl) × Col1a2; Cre-ER mice were protected from bleomycin-induced dermal with a reduction of skin thickening by 71% (P < 0.05). Conclusions. We demonstrated a prominent activation of canonical Wnt signalling in SSc with nuclear accumulation of β-catenin in fibroblasts and activation of the target gene axin-2. Our results showed that fibroblast-specific stabilization of β-catenin resulted in enhanced collagen release, whereas deletion of β-catenin potently reduced collagen production. Together, our findings highlight a key role of β-catenin in fibroblast activation and fibrosis. Thus, β-catenin may be promising molecular target for anti-fibrotic therapies

Published
2017

30. Abstract P2-09-05: LCCC 1525: A phase II study of a priming dose of cyclophosphamide prior to pembrolizumab to treat metastatic triple negative breast cancer (mTNBC)

Author

Anders, CK, primary, Moore, D, additional, Sambade, M, additional, Cuaboy, L, additional, Garrett, A, additional, Woodcock, M, additional, McKinnon, K, additional, Cowens, K, additional, Bortone, D, additional, Calhoun, B, additional, Carey, L, additional, Dees, C, additional, Jolly, T, additional, Muss, H, additional, Reeder-Hayes, K, additional, Kaltman, R, additional, Jankowitz, R, additional, Gudena, V, additional, Olajide, O, additional, Perou, C, additional, Vincent, B, additional, and Serody, J, additional

Published
2019
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32. FRI0401 The tyrosine phosphatase shp2 controls tgfΒ-induced stat3 signalling to regulate fibroblast activation and fibrosis

Author

Zehender, A., primary, Huang, J., additional, Györfi, A.-H., additional, Matei, A.-E., additional, Dees, C., additional, Beyer, C., additional, Gelse, K., additional, Ramming, A., additional, Bergmann, C., additional, Birchmeier, W., additional, Distler, O., additional, Schett, G., additional, and Distler, J., additional

Published
2018
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37. Final edition: November 2003

Author

Dees, C. Stanley

Subjects
United States. Department of Defense -- Laws, regulations and rules, United States. Senate -- Laws, regulations and rules, Seafood industry -- Laws, regulations and rules, Government regulation, Business, general, Business, Department of Defense Appropriations Act 2004, National Defense Authorization Act for Fiscal Year 2003, Buy American Act
Abstract

Legislation President Bush Signs Defense Appropriations Bill On September 30, 2003, President Bush signed into law the Department of Defense Appropriations Act 2004. The law includes a provision authored by [...]

Published
2003

38. Final edition: August 2003

Author

Dees, C. Stanley

Subjects
United States. Department of Defense -- Laws, regulations and rules -- Political activity, Contracts -- Management, Building -- Laws, regulations and rules, Construction industry -- Laws, regulations and rules -- Labor relations, Government regulation, Business, general, Business
Abstract

Legislation Bills Regarding Labor Relations Neutrality Introduced in House Representatives John Sullivan and Sam Johnson have introduced bills which would, if enacted, prevent government agencies from preventing or requiring contractors [...]

Published
2003

40. SAT0318 Epigenetic regulation of FRA2 by JMJD3 regulates fibroblast activation in systemic sclerosis

Author

Bergmann, C, primary, Brandt, A, additional, Dees, C, additional, Wohlfahrt, T, additional, Zhang, Y, additional, Chen, C-W, additional, Mallano, T, additional, Liang, R, additional, Kagwiria, R, additional, Kam, P-S, additional, Bozec, A, additional, Abraham, D, additional, Rieker, R, additional, Ramming, A, additional, Distler, O, additional, Schett, G, additional, and Distler, J, additional

Published
2017
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43. A phase 1b study of abemaciclib, an inhibitor of CDK4 and CDK6, in combination with endocrine and HER2-targeted therapies for patients with metastatic breast cancer

Author

Beeram, M., primary, Tolaney, S.M., additional, Beck, J.T., additional, Dickler, M.N., additional, Conlin, A.K., additional, Dees, C., additional, Helsten, T.L., additional, Conkling, P.R., additional, Edenfield, W.J., additional, Richards, D.A., additional, Kambhampati, S.R.P., additional, Costigan, T.M., additional, Chan, E., additional, Pant, S., additional, Kalinsky, K., additional, Burris, H.A., additional, Becerra, C.H., additional, Rexer, B.N., additional, Puhalla, S.L., additional, and Goetz, M.P., additional

Published
2016
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44. OP0051 Dipeptidyl-Peptidase-4 (DPP4) Characterizes A Subpopulation of Fibrosis-Promoting Fibroblasts and Is A Molecular Target for The Treatment of Fibrosis

Author

Soare, A.M., primary, Dees, C., additional, Zhang, Y., additional, Liang, R., additional, Wohlfahrt, T., additional, Rauber, S., additional, Lin, N., additional, Chen, C.-W., additional, Ramming, A., additional, Distler, O., additional, Mihai, C., additional, Schett, G., additional, and Distler, J., additional

Published
2016
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48. Inhibition of AP-1 signaling abrogates TGF-ß mediated activation of fibroblasts and prevents experimental fibrosis

Author

Avouac, J, Palumbo, K, Tomcik, M, Zerr, P, Dees, C, Horn, A, Maurer, B, Akhmetshina, A, Beyer, C, Sadowski, A, Schneider, H, Shiozawa, S, Distler, O, Schett, G, Allanore, Y, Distler, J H W, University of Zurich, and Avouac, J

Subjects
2403 Immunology, 2745 Rheumatology, 10051 Rheumatology Clinic and Institute of Physical Medicine, 2723 Immunology and Allergy, 2736 Pharmacology (medical), 610 Medicine & health
Published
2012
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49. FINAL EDITION

Author

Dees, C. Stanley

Subjects
United States. General Services Administration -- Powers and duties, Bills, Legislative -- Reports, Prisons -- Laws, regulations and rules, Patents -- Laws, regulations and rules, Public contracts -- Laws, regulations and rules, Space sciences -- Laws, regulations and rules, Wages -- Minimum wage, Industrial design -- Laws, regulations and rules, Contractors -- Laws, regulations and rules, Business, Business, general
Abstract

OCTOBER 2001 Legislation Bill Regarding Procurement of Products from Federal Prison Industries Introduced in the Senate Senator Carl Levin has introduced a bill to revise the requirements for the procurement [...]

Published
2001

50. DOD, GSA, and NASA Issue Interim Rule Regarding Designation of a Single Point of Universal Electronic Access to Governmentwide Procurement

Author

Dees, C. Stanley

Subjects
United States. Department of Defense -- Laws, regulations and rules, United States. General Services Administration -- Laws, regulations and rules, United States. National Aeronautics and Space Administration -- Laws, regulations and rules, Government purchasing -- Technology application, Electronic commerce -- Usage, Public contracts -- Laws, regulations and rules, Business, Business, general
Abstract

The Department of Defense (DOD), General Services Administration (GSA), and National Aeronautics and Space Administration (NASA) have issued an interim rule regarding the designation of a single point of universal [...]

Published
2001

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