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2. Islet-after-kidney transplantation versus kidney alone in kidney transplant recipients with type 1 diabetes (KAIAK): a population-based target trial emulation in France

Author

Armanet, Mathieu, Auxenfans, Céline, Averland, Benoit, Benhamou, Pierre-Yves, Benotmane, Ilies, Berishvili, Ekaterine, Bertrand, Dominique, Blanot, Stéphane, Borot, Sophie, Branchereau, Julien, Broca, Christophe, Brunet, Valérie, Cattan, Pierre, Chaillous, Lucy, Chatauret, Nicolas, Cheisson, Gaelle, Ciacio, Oriana, Colosio, Charlotte, Cornuault, Mathieu, Cuellar, Emmanuel, Defortescu, Guillaume, Defrance, Frédérique, Deshayes, Aurélie, Divard, Gillian, Domet, Thomas, Duffas, Jean-Pierre, Elias, Michelle, Faivre, Lionel, Gaudez, François, Giral, Magali, Girerd, Sophie, Gmyr, Valery, Gouin, Philippe, Gregoire, Hélène, Gueguen, Juliette, Haidar, Fadi, Hubert, Thomas, Janbon, Bénédicte, Jeantet, Marine, Karam, Georges, Kerbaul, François, Kerleau, Clarisse, Kounis, Ilias, Laporte, Caroline, Laurent, Charlotte, Lejay, Anne, Masset, Christophe, Mazeaud, Charles, Mokri, Laëtitia, Moreau, Karine, Morellon, Emmanuel, Muscari, Fabrice, Nasone, Justine, Padilla, Marc, Parier, Bastien, Pastural, Myriam, Perrier, Quentin, Pittau, Gabriella, Prudhomme, Thomas, Renard, Eric, Raverdy, Violeta, Sá Cunha, António, Salloum, Chady, Seizilles De Mazancourt, Emilien, Snanoudj, Renaud, Thaunat, Oliver, Thuret, Rodolphe, Timsit, Marc-Oliver, Vachiery-Lahaye, Florence, Maanaoui, Mehdi, Lenain, Rémi, Foucher, Yohann, Buron, Fanny, Blancho, Gilles, Antoine, Corinne, Caillard, Sophie, Kessler, Laurence, Le Quintrec, Moglie, Villard, Orianne, Anglicheau, Dany, Büchler, Matthias, Brodin-Sartorius, Albane, Frimat, Luc, Malvezzi, Paolo, Lablanche, Sandrine, Badet, Lionel, Esposito, Laure, Chetboun, Mikael, Hamroun, Aghiles, Kerr-Conte, Julie, Berney, Thierry, Vantyghem, Marie-Christine, Hazzan, Marc, and Pattou, François

Published
2024
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3. The concept of immunothrombosis in pancreas transplantation

Author

Catargi, Bogdan, Moreau, Karine, Andres, Axel, Berishvili, Ekaterine, Haidar, Fadi, Wassmer, Charles-Henri, Benhamou, Pierre Yves, Lablanche, Sandrine, Malvezzi, Paolo, Perrier, Quentin, Tetaz, Rachel, Chetboun, Mikael, Frimat, Marie, Kerr-Conte, Julie, Defrance, Frédérique, Mapihan, Kristell Le, Maanaoui, Mehdi, Pattou, François, Vantyghem, Marie-Christine, Badet, Lionel, Berney, Thierry, Buron, Fanny, Matillon, Xavier, Morelon, Emmanuel, Reffet, Sophie, Thaunat, Olivier, Garrigue, Valérie, Panaro, Fabrizio, Renard, Eric, Serre, Jean-Emmanuel, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Chailloux, Lucy, Masset, Christophe, Mahot-Moreau, Pascale, Mesnard, Benoit, Armanet, Mathieu, Cattan, Pierre, Ciacio, Oriana, Durrbach, Antoine, Elias, Michelle, Gaudez, François, Pittau, Gabriella, Riveline, Jean-Pierre, Sacunha, Antonio, Sartorius, Albane, Snanoudj, Renaud, Vidal-Trecan, Tiphaine, Caillard, Sophie, Kessler, Laurence, Lejay, Anne, Cuellar, Emmanuel, Duffas, Jean-Pierre, Esposito, Laure, Hanaire, Hélène, Kamar, Nassim, Prudhomme, Thomas, Buchler, Mathias, Gueguen, Juliette, Drillaud, Nicolas, Ternisien, Catherine, Degauque, Nicolas, Gerard, Nathalie, Bruneau, Sarah, Brouard, Sophie, Giral, Magali, and Dantal, Jacques

Published
2024
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5. Cognitive Outcome After Islet Transplantation

Author

Mailliez, Aurélie, Ternynck, Camille, Jannin, Arnaud, Lemaître, Madleen, Chevalier, Benjamin, Le Mapihan, Kristell, Defrance, Frédérique, Mackowiak, Marie-Anne, Rollin, Adeline, Mehdi, Maanaoui, Chetboun, Mikael, Pattou, François, Pasquier, Florence, and Vantyghem, Marie-Christine

Published
2023
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6. Liste des collaborateurs

Author

Balavoine, Anne-Sophie, primary, Beron, Amandine, additional, Cardot-Bauters, Catherine, additional, Carnaille, Bruno, additional, Caron, Philippe, additional, d'Herbomez, Michèle, additional, Defrance, Frédérique, additional, Do Cao, Christine, additional, Espiard, Stéphanie, additional, Ghander, Cécile, additional, Guerreschi, Pierre, additional, Ladsous, Miriam, additional, Leteurtre, Emmanuelle, additional, Lion, Georges, additional, Marks-Delesalle, Caroline, additional, Proust, Emmanuelle, additional, Raverot, Véronique, additional, Russ, Gilles, additional, Ryndak-Swiercz, Amélie, additional, Smirnov, Vasily, additional, Weill, Jacques, additional, and Wémeau, Jean-Louis, additional

Published
2022
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8. Islet-after-kidney transplantation versus kidney alone in kidney transplant recipients with type 1 diabetes (KAIAK): a population-based target trial emulation in France

Author

Maanaoui, Mehdi, Lenain, Rémi, Foucher, Yohann, Buron, Fanny, Blancho, Gilles, Antoine, Corinne, Caillard, Sophie, Kessler, Laurence, Le Quintrec, Moglie, Villard, Orianne, Anglicheau, Dany, Büchler, Matthias, Brodin-Sartorius, Albane, Frimat, Luc, Malvezzi, Paolo, Lablanche, Sandrine, Badet, Lionel, Esposito, Laure, Chetboun, Mikael, Hamroun, Aghiles, Kerr-Conte, Julie, Berney, Thierry, Vantyghem, Marie-Christine, Hazzan, Marc, Pattou, François, Armanet, Mathieu, Auxenfans, Céline, Averland, Benoit, Benhamou, Pierre-Yves, Benotmane, Ilies, Berishvili, Ekaterine, Bertrand, Dominique, Blanot, Stéphane, Borot, Sophie, Branchereau, Julien, Broca, Christophe, Brunet, Valérie, Cattan, Pierre, Chaillous, Lucy, Chatauret, Nicolas, Cheisson, Gaelle, Ciacio, Oriana, Colosio, Charlotte, Cornuault, Mathieu, Cuellar, Emmanuel, Defortescu, Guillaume, Defrance, Frédérique, Deshayes, Aurélie, Divard, Gillian, Domet, Thomas, Duffas, Jean-Pierre, Elias, Michelle, Faivre, Lionel, Gaudez, François, Giral, Magali, Girerd, Sophie, Gmyr, Valery, Gouin, Philippe, Gregoire, Hélène, Gueguen, Juliette, Haidar, Fadi, Hubert, Thomas, Janbon, Bénédicte, Jeantet, Marine, Karam, Georges, Kerbaul, François, Kerleau, Clarisse, Kounis, Ilias, Laporte, Caroline, Laurent, Charlotte, Lejay, Anne, Masset, Christophe, Mazeaud, Charles, Mokri, Laëtitia, Moreau, Karine, Morellon, Emmanuel, Muscari, Fabrice, Nasone, Justine, Padilla, Marc, Parier, Bastien, Pastural, Myriam, Perrier, Quentin, Pittau, Gabriella, Prudhomme, Thomas, Renard, Eric, Raverdy, Violeta, Sá Cunha, António, Salloum, Chady, Seizilles De Mazancourt, Emilien, Snanoudj, Renaud, Thaunat, Oliver, Thuret, Rodolphe, Timsit, Marc-Oliver, and Vachiery-Lahaye, Florence

Abstract

Islet transplantation has been associated with better metabolic control and quality of life than insulin treatment alone, but direct evidence of its effect on hard clinical endpoints is scarce. We aimed to assess the effect of islet transplantation on patient-graft survival in kidney transplant recipients with type 1 diabetes.

Published
2024
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9. Association between HOMA2 based beta-cell function or insulin resistance and long-term outcomes in kidney transplant recipients with type 2 diabetes

Author

Maanaoui, Mehdi, primary, Debillon, Florence, additional, Lenain, Rémi, additional, Defrance, Frédérique, additional, Vantyghem, Marie-Christine, additional, Triempont, Marine Van, additional, Provôt, François, additional, Chetboun, Mikael, additional, Kerr-Conte, Julie, additional, Hamroun, Aghiles, additional, Frimat, Marie, additional, Raverdy, Violeta, additional, Pattou, François, additional, Hazzan, Marc, additional, and Glowacki, François, additional

Published
2024
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10. Primary Graft Function and 5 Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study

Author

Chetboun, Mikael, primary, Masset, Christophe, additional, Maanaoui, Mehdi, additional, Defrance, Frédérique, additional, Gmyr, Valéry, additional, Raverdy, Violeta, additional, Hubert, Thomas, additional, Bonner, Caroline, additional, Supiot, Lisa, additional, Kerleau, Clarisse, additional, Blancho, Gilles, additional, Branchereau, Julien, additional, Karam, Georges, additional, Chelghaf, Ismaël, additional, Houzet, Aurélie, additional, Giral, Magali, additional, Garandeau, Claire, additional, Dantal, Jacques, additional, Le Mapihan, Kristell, additional, Jannin, Arnaud, additional, Hazzan, Marc, additional, Caiazzo, Robert, additional, Kerr-Conte, Julie, additional, Vantyghem, Marie-Christine, additional, Cantarovich, Diego, additional, and Pattou, François, additional

Published
2023
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12. Primary Graft Function and 5Year Insulin Independence After Pancreas and Islet Transplantation for Type 1 Diabetes: A Retrospective Parallel Cohort Study.

Author

Chetboun, Mikael, Masset, Christophe, Maanaoui, Mehdi, Defrance, Frédérique, Gmyr, Valéry, Raverdy, Violeta, Hubert, Thomas, Bonner, Caroline, Supiot, Lisa, Kerleau, Clarisse, Blancho, Gilles, Branchereau, Julien, Karam, Georges, Chelghaf, Ismaël, Houzet, Aurélie, Giral, Magali, Garandeau, Claire, Dantal, Jacques, Mapihan, Kristell Le, and Jannin, Arnaud

Subjects
TYPE 1 diabetes, PANCREAS transplantation, INSULIN, COHORT analysis, PANCREATIC beta cells
Abstract

In islet transplantation (ITx), primary graft function (PGF) or beta cell function measured early after last infusion is closely associated with long term clinical outcomes. We investigated the association between PGF and 5 year insulin independence rate in ITx and pancreas transplantation (PTx) recipients. This retrospective multicenter study included type 1 diabetes patients who underwent ITx in Lille and PTx in Nantes from 2000 to 2022. PGF was assessed using the validated Beta2-score and compared to normoglycemic control subjects. Subsequently, the 5 year insulin independence rates, as predicted by a validated PGF-based model, were compared to the actual rates observed in ITx and PTx patients. The study enrolled 39 ITx (23 ITA, 16 IAK), 209 PTx recipients (23 PTA, 14 PAK, 172 SPK), and 56 normoglycemic controls. Mean[SD] PGF was lower after ITx (ITA 22.3[5.2], IAK 24.8[6.4], than after PTx (PTA 38.9[15.3], PAK 36.8[9.0], SPK 38.7[10.5]), and lower than mean beta-cell function measured in normoglycemic control: 36.6[4.3]. The insulin independence rates observed at 5 years after PTA and PAK aligned with PGF predictions, and was higher after SPK. Our results indicate a similar relation between PGF and 5 year insulin independence in ITx and solitary PTx, shedding new light on long-term transplantation outcomes [ABSTRACT FROM AUTHOR]

Published
2024
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13. How to diagnose a lipodystrophy syndrome

Author

Vantyghem, Marie-Christine, Balavoine, Anne-Sophie, Douillard, Claire, Defrance, Frédérique, Dieudonne, Lucile, Mouton, Fanny, Lemaire, Christine, Bertrand-Escouflaire, Nicole, Bourdelle-Hego, Marie-Françoise, Devemy, Fabrice, Evrard, Anne, Gheerbrand, Dominique, Girardot, Caroline, Gumuche, Sophie, Hober, Christine, Topolinski, Hélène, Lamblin, Blandine, Mycinski, Bénédicte, Ryndak, Amélie, Karrouz, Wassila, Duvivier, Etienne, Merlen, Emilie, Cortet, Christine, Weill, Jacques, Lacroix, Dominique, and Wémeau, Jean-Louis

Published
2012
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17. Continuous Glucose Monitoring after Islet Transplantation in Type 1 Diabetes: An Excellent Graft Function (β-Score Greater Than 7) Is Required to Abrogate Hyperglycemia, Whereas a Minimal Function Is Necessary to Suppress Severe Hypoglycemia (β-Score Greater Than 3)

Author

Vantyghem, Marie-Christine, Raverdy, Violeta, Balavoine, Anne-Sophie, Defrance, Frédérique, Caiazzo, Robert, Arnalsteen, Laurent, Gmyr, Valéry, Hazzan, Marc, Noël, Christian, Kerr-Conte, Julie, and Pattou, Francois

Published
2012

19. The concept of immunothrombosis in pancreas transplantation

Author

Masset, Christophe, Drillaud, Nicolas, Ternisien, Catherine, Degauque, Nicolas, Gerard, Nathalie, Bruneau, Sarah, Branchereau, Julien, Blancho, Gilles, Mesnard, Benoit, Brouard, Sophie, Giral, Magali, Cantarovich, Diego, Dantal, Jacques, Catargi, Bogdan, Moreau, Karine, Andres, Axel, Berishvili, Ekaterine, Haidar, Fadi, Wassmer, Charles-Henri, Benhamou, Pierre Yves, Lablanche, Sandrine, Malvezzi, Paolo, Perrier, Quentin, Tetaz, Rachel, Chetboun, Mikael, Frimat, Marie, Kerr-Conte, Julie, Defrance, Frédérique, Mapihan, Kristell Le, Maanaoui, Mehdi, Pattou, François, Vantyghem, Marie-Christine, Badet, Lionel, Berney, Thierry, Buron, Fanny, Matillon, Xavier, Morelon, Emmanuel, Reffet, Sophie, Thaunat, Olivier, Garrigue, Valérie, Panaro, Fabrizio, Renard, Eric, Serre, Jean-Emmanuel, Blancho, Gilles, Branchereau, Julien, Cantarovich, Diego, Chailloux, Lucy, Masset, Christophe, Mahot-Moreau, Pascale, Mesnard, Benoit, Armanet, Mathieu, Cattan, Pierre, Ciacio, Oriana, Durrbach, Antoine, Elias, Michelle, Gaudez, François, Pittau, Gabriella, Riveline, Jean-Pierre, Sacunha, Antonio, Sartorius, Albane, Snanoudj, Renaud, Vidal-Trecan, Tiphaine, Caillard, Sophie, Kessler, Laurence, Lejay, Anne, Cuellar, Emmanuel, Duffas, Jean-Pierre, Esposito, Laure, Hanaire, Hélène, Kamar, Nassim, Prudhomme, Thomas, Buchler, Mathias, and Gueguen, Juliette

Abstract

Early failure of a pancreatic allograft due to complete thrombosis has an incidence of approximately 10% and is the main cause of comorbidity in pancreas transplantation. Although several risk factors have been identified, the exact mechanisms leading to this serious complication are still unclear. In this review, we define the roles of the individual components involved during sterile immunothrombosis—namely endothelial cells, platelets, and innate immune cells. Further, we review the published evidence linking the main risk factors for pancreatic thrombosis to cellular activation and vascular modifications. We also explore the unique features of the pancreas itself: the vessel endothelium, specific vascularization, and relationship to other organs—notably the spleen and adipose tissue. Finally, we summarize the therapeutic possibilities for the prevention of pancreatic thrombosis depending on the different mechanisms such as anticoagulation, anti-inflammatory molecules, endothelium protectors, antagonism of damage-associated molecular patterns, and use of machine perfusion.

Published
2024
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20. Management of endocrino-metabolic dysfunctions after allogeneic hematopoietic stem cell transplantation

Author

Vantyghem, Marie-Christine, primary, Cornillon, Jérôme, additional, Decanter, Christine, additional, Defrance, Frédérique, additional, Karrouz, Wassila, additional, Leroy, Clara, additional, Le Mapihan, Kristell, additional, Couturier, Marie-Anne, additional, De Berranger, Eva, additional, Hermet, Eric, additional, Maillard, Natacha, additional, Marcais, Ambroise, additional, Francois, Sylvie, additional, Tabrizi, Reza, additional, and Yakoub-Agha, Ibrahim, additional

Published
2014
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