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1,256 results on '"Degenerative"'

6. The Effect of Muscle Quality on Outcomes after Microdiscectomy

Author

Heard, Jeremy C., Kohli, Meera, Ezeonu, Teeto, Lee, Yunsoo, Lambrechts, Mark J., Narayanan, Rajkishen, Kirkpatrick, Quinn, Kern, Nathaniel, Canseco, Jose A., Kurd, Mark F., Kaye, Ian D., Hilibrand, Alan S., Vaccaro, Alexander R., Schroeder, Gregory D., and Kepler, Christopher K.

Published
2024
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14. Surgery in degenerative spondylolisthesis: does fusion improve outcome in subgroups? A secondary analysis from a randomized trial (NORDSTEN trial)

Author

Hellum, Christian, Rekeland, Frode, Småstuen, Milada Cvancarova, Solberg, Tore, Hermansen, Erland, Storheim, Kjersti, Brox, Jens Ivar, Furunes, Håvard, Franssen, Eric, Weber, Clemens, Brisby, Helena, Grundnes, Oliver, Algaard, Knut Robert Hector, Böker, Tordis, Banitalebi, Hasan, Indrekvam, Kari, and Austevoll, Ivar Magne

Published
2023
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48. A comparison of clinical and radiological outcomes following laminectomy and laminectomy with fusion in patients of cervical spondylotic myelopathy: A systematic review and meta-analysis.

Author

Reddy, Duddukunta Vishal, Satapathy, Deepankar, Raja, Balgovind S., Maley, Deepak Kumar, Ahuja, Kaustubh, Yalamanchili, Ranjith Kumar, Lakkireddy, Maheshwar, and Ifthekar, Syed

Subjects
*CERVICAL spondylotic myelopathy, *NEUROMUSCULAR system physiology, *CERVICAL vertebrae, *LAMINECTOMY, *ELECTRONIC information resource searching
Abstract

To conduct a systematic review and meta-analysis comparing the functional and radiological outcomes in cervical spondylotic myelopathy (CSM) when treated by Laminectomy (LC) vs. laminectomy with instrumented fusion (LCF). The systematic review was conducted in accordance with PRISMA guidelines. A systematic electronic search was performed in PubMed, EMBASE, and CENTRAL databases. All Studies comparing clinical and radiological outcomes in patients with CSM when treated with LCF and LC were included in the systematic review. Neuromuscular function measured by modified Japanese orthopaedic association (mJOA), Cervical lordosis measured by C2-C7 Cobb's angle, and data on complications were retrieved from the studies. Random effect meta-analysis was used to account for heterogeneity. Quality assessment was performed using ROBINS-I and ROB-2 tools. Certainty of evidence was assessed using the GRADE working group recommendations. A total of 3985 articles were retrieved from the databases, of which 9 articles (1 RCT, 8 controlled comparative trials; n = 1146) met the eligibility criteria. The improvement in mJOA showed results favouring laminectomy with fusion with an SMD of 0.45 (95% CI, 0.07–0.84; p = 0.02). The loss of cervical lordosis was significantly lesser in the laminectomy with fusion group with an SMD of − 0.454 (95% CI, (− 0.12) – (− 0.79), p = 0.01). The complication rate in the LCF group was lower (LogOR = − 0.92; 95% CI: (− 1.30) – (− 0.55); p = < 0.05). In CSM, laminectomy with fusion is superior to standalone laminectomy in terms of improvement in m-JOA, maintenance of cervical lordosis and reduction in complications. [ABSTRACT FROM AUTHOR]

Published
2024
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49. Exploring the impact of body mass index on the accuracy of vertebral bone quality in determining bone mineral density in patients undergoing lumbar fusion surgery.

Author

Zhao, Xuan, Wang, Qijun, Wang, Peng, Kong, Chao, and Lu, Shibao

Subjects
*LUMBAR vertebrae surgery, *PREDICTIVE tests, *PEARSON correlation (Statistics), *BODY mass index, *BONE density, *RESEARCH funding, *RECEIVER operating characteristic curves, *QUESTIONNAIRES, *RETROSPECTIVE studies, *SPINAL fusion, *MEDICAL records, *ACQUISITION of data, *OSTEOPOROSIS, *REGRESSION analysis
Abstract

Objective: To investigate whether body mass index (BMI) affects the accuracy of vertebral bone quality (VBQ) in determining bone mineral density (BMD) in patients undergoing lumbar fusion surgery. Methods: In this retrospective study, patients with preoperative noncontrast T1-weighted MRI were included. Restricted Cubic Spline (RCS) was employed to explore the nonlinear relationship between BMI and VBQ. Then patients were stratified according to the threshold of BMI. Pearson correlation analysis and linear regression were used to analyze the correlation between VBQ and the BMD in different groups. Receiver operating characteristic (ROC) analysis to calculate the area under the curve (AUC) was used to assess diagnostic efficacy according to BMI. Results: A total of 328 patients (201 female and 127 male patients) with a mean age of 68.3 ± 3.3 years were included in the study. Significant nonlinear relationship was observed given the results of RCS. In patients with BMI < 23.8 kg/m2, the correlation coefficient between VBQ and the lowest BMD was − 0.32 and significant distribution difference of VBQ score was observed between osteoporosis and normal as well as osteopenia subgroups. However, in patients with BMI ≥ 23.8 kg/m2, the correlation coefficient between VBQ and the lowest BMD was − 0.39 and significant distribution difference of VBQ score was observed in all three subgroups. In addition, the ROC analysis revealed that the predictive performance in determining low BMD was superior in patients with BMI ≥ 23.8 kg/m2 (AUC 0.80 vs. AUC 0.66, p = 0.034). Conclusions: In this study, significant nonlinear relationship between BMI and VBQ was observed. Compared with patients with BMI < 23.8 kg/m2, VBQ has better discrimination between higher BMI (≥ 23.8 kg/m2) patients with low BMD and those with normal bone density. [ABSTRACT FROM AUTHOR]

Published
2024
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50. Myxomatous mitral valve disease in Labrador Retrievers and Golden Retrievers.

Author

Wilson, Bailey A. and Wesselowski, Sonya

Subjects
*GOLDEN retriever, *LABRADOR retriever, *MITRAL valve prolapse, *VENTRICULAR arrhythmia, *ATRIAL fibrillation, *MITRAL valve
Abstract

To characterize myxomatous mitral valve disease (MMVD) in Labrador Retrievers (LRs) and Golden Retrievers (GRs). METHODS 52 LRs and 20 GRs diagnosed with MMVD composed a retrospective study sample (February 1, 2010, to July 31, 2021). Stored echocardiograms were remeasured. Dogs were staged by 2019 MMVD consensus guidelines. RESULTS Mean age was 9.9 years in LRs and 9.5 years in GRs, with 31 of 52 LRs (59.6%) and 13 of 20 (65.0%) GRs being male. Forty-six LRs were stage B1 (88.5%), 3 were B2 (5.8%), and 3 were C (5.8%). Fourteen GRs were stage B1 (70.0%), 2 were B2 (10.0%), and 4 were C (20.0%). Of LRs and GRs in stage B2/C, 50% had systolic dysfunction. Atrial fibrillation (AF) and ventricular arrhythmias were identified in 2 of 52 (3.8%) and 10 of 52 (19.2%) LRs at initial diagnosis versus 3 of 20 (15.0%) and 3 of 20 (15.0%) GRs, respectively. All 5 AF dogs were stage C, with intermediate to high probability of pulmonary hypertension. Two additional GRs developed AF during follow-up; thus 5 of 6 (83.3%) stage B2/C GRs ultimately experienced AF. Subjective mitral valve thickening was frequent in both breeds (41/52 LRs [78.8%]; 18/20 GRs [90.0%]), while mitral valve prolapse was more common in LRs (22/52 [42.3%]) than GRs (5/20 [25.0%]). CONCLUSIONS In LRs and GRs, MMVD was relatively late onset, with males overrepresented. Both breeds exhibited mitral valve thickening in association with MMVD, while LRs more commonly exhibited mitral valve prolapse. CLINICAL RELEVANCE While most LRs and GRs with MMVD were stage Bl, those in stage B2/C had increased prevalence of systolic dysfunction and AF. [ABSTRACT FROM AUTHOR]

Published
2024
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