Search

Your search keyword '"Deigin, Vladislav"' showing total 14 results
Start Over Author "Deigin, Vladislav"
14 results on '"Deigin, Vladislav"'

3. The First Reciprocal Activities of Chiral Peptide Pharmaceuticals: Thymogen and Thymodepressin, as Examples.

Author

Deigin, Vladislav, Linkova, Natalia, Vinogradova, Julia, Vinogradov, Dmitrii, Polyakova, Victoria, Medvedev, Dmitrii, Krasichkov, Alexander, and Volpina, Olga

Subjects
*PEPTIDE drugs, *AMINO acid sequence, *BIOLOGICAL systems, *AMINO acids, *CHIRAL drugs, *ENANTIOMERS
Abstract

Peptides show high promise in the targeting and intracellular delivery of next-generation biotherapeutics. The main limitation is peptides' susceptibility to proteolysis in biological systems. Numerous strategies have been developed to overcome this challenge by chemically enhancing the resistance to proteolysis. In nature, amino acids, except glycine, are found in L- and D-enantiomers. The change from one form to the other will change the primary structure of polypeptides and proteins and may affect their function and biological activity. Given the inherent chiral nature of biological systems and their high enantiomeric selectivity, there is rising interest in manipulating the chirality of polypeptides to enhance their biomolecular interactions. In this review, we discuss the first examples of up-and-down homeostasis regulation by two enantiomeric drugs: immunostimulant Thymogen (L-Glu-L-Trp) and immunosuppressor Thymodepressin (D-Glu(D-Trp)). This study shows the perspective of exploring chirality to remove the chiral wall between L- and D-biomolecules. The selected clinical result will be discussed. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results