591 results on '"Deinum, Jaap"'
Search Results
2. Urine steroid metabolomics as a diagnostic tool in primary aldosteronism
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Prete, Alessandro, Lang, Katharina, Pavlov, David, Rhayem, Yara, Sitch, Alice J., Franke, Anna S., Gilligan, Lorna C., Shackleton, Cedric H.L., Hahner, Stefanie, Quinkler, Marcus, Dekkers, Tanja, Deinum, Jaap, Reincke, Martin, Beuschlein, Felix, Biehl, Michael, and Arlt, Wiebke
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- 2024
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3. Electrolyte Disorders in Mitochondrial Cytopathies: A Systematic Review
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Viering, Daan H.H.M., Vermeltfoort, Lars, Bindels, René J.M., Deinum, Jaap, and de Baaij, Jeroen H.F.
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- 2023
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4. Stepwise treatment of uncontrolled HyperTensioN (Stepwise-HTN): Study design of a cluster randomised controlled trial in primary care
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Kiliç, Birsen, Biermans, Marion C.J., Rutten, Frans H., Deinum, Jaap, Spiering, Wilko, van der Wel, Mark C., de Grauw, Wim J.C., Bots, Michiel L., and Hollander, Monika
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- 2023
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5. Monogenic forms of low-renin hypertension: clinical and molecular insights
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Khandelwal, Priyanka and Deinum, Jaap
- Subjects
Nucleotide sequencing -- Methods -- Health aspects ,DNA sequencing -- Methods -- Health aspects ,Hypertension -- Genetic aspects -- Diagnosis -- Prognosis ,Health - Abstract
Monogenic disorders of hypertension are a distinct group of diseases causing dysregulation of the renin-angiotensin-aldosterone system and are characterized by low plasma renin activity. These can chiefly be classified as causing (i) excessive aldosterone synthesis (familial hyperaldosteronism), (ii) dysregulated adrenal steroid metabolism and action (apparent mineralocorticoid excess, congenital adrenal hyperplasia, activating mineralocorticoid receptor mutation, primary glucocorticoid resistance), and (iii) hyperactivity of sodium and chloride transporters in the distal tubule (Liddle syndrome and pseudohypoaldosteronism type 2). The final common pathway is plasma volume expansion and catecholamine/sympathetic excess that causes urinary potassium wasting; hypokalemia and early-onset refractory hypertension are characteristic. However, several single gene defects may show phenotypic heterogeneity, presenting with mild hypertension with normal electrolytes. Evaluation is based on careful attention to family history, physical examination, and measurement of blood levels of potassium, renin, and aldosterone. Genetic sequencing is essential for precise diagnosis and individualized therapy. Early recognition and specific management improves prognosis and prevents long-term sequelae of severe hypertension., Author(s): Priyanka Khandelwal [sup.1] , Jaap Deinum [sup.2] Author Affiliations: (1) grid.413618.9, 0000 0004 1767 6103, Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, , 110029, [...]
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- 2022
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6. Predicting surgical outcome in posterior retroperitoneoscopic adrenalectomy with the aid of a preoperative nomogram
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van Uitert, Allon, van de Wiel, Elle C. J., Ramjith, Jordache, Deinum, Jaap, Timmers, Henri J. L. M., Witjes, J. Alfred, Kool, Leo J. Schultze, and Langenhuijsen, Johan F.
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- 2022
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7. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial
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Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanassche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Maria Lorenza, Muiesan, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Aleksandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martínez García, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Michael Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Davis, William Ross, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, and Wang, Ji-Guang
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- 2022
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8. Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
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Bliziotis, Nikolaos G., Kluijtmans, Leo A. J., Soto, Sebastian, Tinnevelt, Gerjen H., Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Engelke, Udo F. H., Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Prehn, Cornelia, Adamski, Jerzy, Januszewicz, Andrzej, Reincke, Martin, Fassnacht, Martin, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Wevers, Ron A., Jansen, Jeroen J., Deinum, Jaap, and Timmers, Henri J. L. M.
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- 2022
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9. Short-Lived Active Prorenin: Precursor of So-Called Native Prorenin
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Schalekamp, Maarten A.D.H., primary, Deinum, Jaap, additional, and Danser, A.H. Jan, additional
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- 2024
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10. Functional tests to guide management in an adult with loss of function of type-1 angiotensin II receptor
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Viering, Daan H. H. M., Bech, Anneke P., de Baaij, Jeroen H. F., Steenbergen, Eric J., Danser, A. H. Jan, Wetzels, Jack F. M., Bindels, René J. M., and Deinum, Jaap
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- 2021
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11. Urine steroid metabolomics as a diagnostic tool in primary aldosteronism
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Prete, Alessandro; https://orcid.org/0000-0002-4821-0336, Lang, Katharina, Pavlov, David, Rhayem, Yara, Sitch, Alice J, Franke, Anna S, Gilligan, Lorna C, Shackleton, Cedric H L, Hahner, Stefanie, Quinkler, Marcus; https://orcid.org/0000-0003-4028-1671, Dekkers, Tanja, Deinum, Jaap; https://orcid.org/0000-0003-2465-1986, Reincke, Martin; https://orcid.org/0000-0002-9817-9875, Beuschlein, Felix; https://orcid.org/0000-0001-7826-3984, Biehl, Michael, Arlt, Wiebke, Prete, Alessandro; https://orcid.org/0000-0002-4821-0336, Lang, Katharina, Pavlov, David, Rhayem, Yara, Sitch, Alice J, Franke, Anna S, Gilligan, Lorna C, Shackleton, Cedric H L, Hahner, Stefanie, Quinkler, Marcus; https://orcid.org/0000-0003-4028-1671, Dekkers, Tanja, Deinum, Jaap; https://orcid.org/0000-0003-2465-1986, Reincke, Martin; https://orcid.org/0000-0002-9817-9875, Beuschlein, Felix; https://orcid.org/0000-0001-7826-3984, Biehl, Michael, and Arlt, Wiebke
- Abstract
Primary aldosteronism (PA) causes 5-10% of hypertension cases, but only a minority of patients are currently diagnosed and treated because of a complex, stepwise, and partly invasive workup. We tested the performance of urine steroid metabolomics, the computational analysis of 24-hour urine steroid metabolome data by machine learning, for the identification and subtyping of PA. Mass spectrometry-based multi-steroid profiling was used to quantify the excretion of 34 steroid metabolites in 24-hour urine samples from 158 adults with PA (88 with unilateral PA [UPA] due to aldosterone-producing adenomas [APAs]; 70 with bilateral PA [BPA]) and 65 sex- and age-matched healthy controls. All APAs were resected and underwent targeted gene sequencing to detect somatic mutations associated with UPA. Patients with PA had increased urinary metabolite excretion of mineralocorticoids, glucocorticoids, and glucocorticoid precursors. Urine steroid metabolomics identified patients with PA with high accuracy, both when applied to all 34 or only the three most discriminative steroid metabolites (average areas under the receiver-operating characteristics curve [AUCs-ROC] 0.95-0.97). Whilst machine learning was suboptimal in differentiating UPA from BPA (average AUCs-ROC 0.65-0.73), it readily identified APA cases harbouring somatic KCNJ5 mutations (average AUCs-ROC 0.79-85). These patients showed a distinctly increased urine excretion of the hybrid steroid 18-hydroxycortisol and its metabolite 18-oxo-tetrahydrocortisol, the latter identified by machine learning as by far the most discriminative steroid. In conclusion, urine steroid metabolomics is a non-invasive candidate test for the accurate identification of PA cases and KCNJ5-mutated APAs.
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- 2024
12. Association of adrenal steroids with metabolomic profiles in patients with primary and endocrine hypertension
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Knuchel, Robin, primary, Erlic, Zoran, additional, Gruber, Sven, additional, Amar, Laurence, additional, Larsen, Casper K., additional, Gimenez-Roqueplo, Anne-Paule, additional, Mulatero, Paolo, additional, Tetti, Martina, additional, Pecori, Alessio, additional, Pamporaki, Christina, additional, Langton, Katharina, additional, Peitzsch, Mirko, additional, Ceccato, Filippo, additional, Prejbisz, Aleksander, additional, Januszewicz, Andrzej, additional, Adolf, Christian, additional, Remde, Hanna, additional, Lenzini, Livia, additional, Dennedy, Michael, additional, Deinum, Jaap, additional, Jefferson, Emily, additional, Blanchard, Anne, additional, Zennaro, Maria-Christina, additional, Eisenhofer, Graeme, additional, and Beuschlein, Felix, additional
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- 2024
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13. Higher SBP in female patients with mitochondrial disease
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Viering, Daan H.H.M., van Borselen, Marjolein D., Deinum, Jaap, Bindels, Rene J.M., de Baaij, Jeroen H.F., and Janssen, Mirian C.H.
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- 2022
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14. Primair hyperaldosteronisme
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Käyser, Sabine and Deinum, Jaap
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- 2020
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15. Healthcare Technology Assessment of Medical Imaging Technology
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Deinum, Jaap, Restovic, Gabriela, Makai, Peter, van der Wilt, Gert Jan, Colom, Laura Sampietro, Kauczor, Hans-Ulrich, Series Editor, Parizel, Paul M., Series Editor, Peh, Wilfred C. G., Series Editor, Brady, Luther W, Series Editor, Lu, Jiade J., Series Editor, Donoso-Bach, Lluís, editor, and Boland, Giles W. L., editor
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- 2018
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16. Feasibility of Imaging-Guided Adrenalectomy in Young Patients With Primary Aldosteronism
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Rossi, Gian Paolo, Crimì, Filippo, Rossitto, Giacomo, Amar, Laurence, Azizi, Michel, Riester, Anna, Reincke, Martin, Degenhart, Christoph, Widimsky, Jiri, Naruse, Mitsuhide, Deinum, Jaap, Kool, Leo Schultze, Kocjan, Tomaz, Negro, Aurelio, Rossi, Ermanno, Kline, Gregory, Tanabe, Akiyo, Satoh, Fumitoshi, Rump, Lars Christian, Vonend, Oliver, Willenberg, Holger S., Fuller, Peter J., Yang, Jun, Chee, Nicholas Yong Nian, Magill, Steven B., Shafigullina, Zulfiya, Quinkler, Marcus, Oliveras, Anna, Wu, Vin Cent, Kratka, Zuzana, Barbiero, Giulio, Battistel, Michele, and Seccia, Teresa Maria
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- 2022
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17. THU593 Unilaterally Selective Adrenal Vein Sampling For Identification Of Surgically Curable Primary Aldosteronism
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Paolo Rossi, Gian, primary, Bagordo, Domenico, additional, Amar, Laurence, additional, Azizi, Michel, additional, Riester, Anna, additional, Reincke, Martin, additional, Degenhart, Christoph, additional, Widimský, Jiří, additional, Naruse, Mitsuhide, additional, Deinum, Jaap, additional, Kocjan, Tomaz, additional, Negro, Aurelio, additional, Rossi, Ermanno, additional, Kline, Gregory, additional, Tanabe, Akiyo, additional, Satoh, Fumitoshi, additional, Christian Rump, Lars, additional, Vonend, Oliver, additional, Willenberg, Holger S, additional, Fuller, Peter J, additional, Yang, Jun, additional, Nian Chee, Nicholas Yong, additional, Magill, Steven B, additional, Shafigullina, Zulfiya, additional, Quinkler, Marcus, additional, Oliveras, Anna, additional, Lee, Bo-Ching, additional, Chang, Chin-Chen, additional, Wu, Vin-Cent, additional, Krátká, Zuzana, additional, Battistel, Michele, additional, Rossitto, Giacomo, additional, and Seccia, Teresa M, additional
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- 2023
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18. FRI135 Differential Expression Of Circulating MicroRNAs In Primary Aldosteronism: Potential Biomarkers For Improved Diagnosis
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Lamprou, Stelios, primary, Mackay MacKenzie, Scott, additional, McClure, John D, additional, Robertson, Stacy, additional, Riddell, Alexandra, additional, van Kralingen, Josie C, additional, Gimenez-Roqueplo, Anne-Paule, additional, Reel, Parminder, additional, Reel, Smarti, additional, Assié, Guillaume, additional, Laurence, Amar, additional, Beuschlein, Felix, additional, Rossi, Gian-Paolo, additional, Deinum, Jaap, additional, Reincke, Martin, additional, Eisenhofer, Graeme, additional, Jefferson, Emily, additional, Zennaro, Maria-Christina, additional, and Davies, Eleanor, additional
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- 2023
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19. Unilaterally Selective Adrenal Vein Sampling for Identification of Surgically Curable Primary Aldosteronism
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Rossi, Gian Paolo, primary, Bagordo, Domenico, additional, Amar, Laurence, additional, Azizi, Michel, additional, Riester, Anna, additional, Reincke, Martin, additional, Degenhart, Christoph, additional, Widimský, Jiří, additional, Naruse, Mitsuhide, additional, Deinum, Jaap, additional, Kocjan, Tomaz, additional, Negro, Aurelio, additional, Rossi, Ermanno, additional, Kline, Gregory, additional, Tanabe, Akiyo, additional, Satoh, Fumitoshi, additional, Rump, Lars Christian, additional, Vonend, Oliver, additional, Willenberg, Holger S., additional, Fuller, Peter J., additional, Yang, Jun, additional, Chee, Nicholas Yong Nian, additional, Magill, Steven B., additional, Shafigullina, Zulfiya, additional, Quinkler, Marcus, additional, Oliveras, Anna, additional, Lee, Bo-Ching, additional, Chang, Chin-Chen, additional, Wu, Vin-Cent, additional, Krátká, Zuzana, additional, Battistel, Michele, additional, Rossitto, Giacomo, additional, and Seccia, Teresa Maria, additional
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- 2023
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20. Genetics, prevalence, screening and confirmation of primary aldosteronism: a position statement and consensus of the Working Group on Endocrine Hypertension of The European Society of Hypertension*
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Mulatero, Paolo, Monticone, Silvia, Deinum, Jaap, Amar, Laurence, Prejbisz, Aleksander, Zennaro, Maria-Christina, Beuschlein, Felix, Rossi, Gian Paolo, Nishikawa, Tetsuo, Morganti, Alberto, Seccia, Teresa Maria, Lin, Yen-Hung, Fallo, Francesco, and Widimsky, Jiri
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- 2020
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21. Outcomes after adrenalectomy for unilateral primary aldosteronism: an international consensus on outcome measures and analysis of remission rates in an international cohort
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Williams, Tracy Ann, Gomez-Sanchez, Celso E, Funder, John W, Reincke, Martin, Adolf, Christian, Amar, Laurence, Auchus, Richard J, Bartsch, Detlef K, Baudrand, Rene, Beuschlein, Felix, Björklund, Peyman, Brown, Morris J, Burrello, Jacopo, Carey, Robert M, Catena, Cristiana, Connell, John M, Deinum, Jaap, Dekkers, Tanja, Fahey, Thomas J, 3rd, Fallo, Francesco, Fardella, Carlos E., Giacchetti, Gilberta, Giraudo, Giuseppe, Hellman, Per, Januszewicz, Andrzej, Kitamoto, Kanako Kiriyama, Kline, Gregory A, Kocjan, Tomaz, Lenders, Jacques W M, Mantero, Franco, Miller, Barbra S, Morimoto, Ryo, Mulatero, Paolo, Naruse, Mitsuhide, Nishikawa, Tetsuo, Pham, Uyen, Plouin, Pierre-François, Prejbisz, Alexander, Quinkler, Marcus, Rottenkolber, Marietta, Rump, Christian L, Satoh, Fumitoshi, Sechi, Leonardo A, Stowasser, Michael, Umakoshi, Hironobu, Veglio, Franco, Widimský, Jirí, Jr, Willenberg, Holger S, Young, William F, Jr, Williams, Tracy A, Kitamoto, Kanako K, and Prejbisz, Aleksander
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- 2017
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22. Correction to: A comparison of high‑throughput plasma NMR protocols for comparative untargeted metabolomics
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Bliziotis, Nikolaos G., Engelke, Udo F. H., Aspers, Ruud L. E. G., Engel, Jasper, Deinum, Jaap, Timmers, Henri J. L. M., Wevers, Ron A., and Kluijtmans, Leo A. J.
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- 2020
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23. A comparison of high-throughput plasma NMR protocols for comparative untargeted metabolomics
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Bliziotis, Nikolaos G., Engelke, Udo F. H., Aspers, Ruud L. E. G., Engel, Jasper, Deinum, Jaap, Timmers, Henri J. L. M., Wevers, Ron A., and Kluijtmans, Leo A. J.
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- 2020
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24. Aldosterone--potassium ratio predicts primary aldosteronism subtype
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Puar, Troy H., Loh, Wann J., Lim, Dawn ST, Loh, Lih M., Zhang, Meifen, Foo, Roger S., Lee, Lynette, Swee, Du S., Khoo, Joan, Tay, Donovan, Kam, Jia W., Dekkers, Tanja, Velema, Marieke, Deinum, Jaap, and Kek, Peng C.
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- 2019
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25. Clinical Outcomes of 1625 Patients With Primary Aldosteronism Subtyped With Adrenal Vein Sampling
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Rossi, Gian Paolo, Rossitto, Giacomo, Amar, Laurence, Azizi, Michel, Riester, Anna, Reincke, Martin, Degenhart, Christoph, Widimsky, Jiri, Jr, Naruse, Mitsuhide, Deinum, Jaap, Schultze Kool, Leo, Kocjan, Tomaz, Negro, Aurelio, Rossi, Ermanno, Kline, Gregory, Tanabe, Akiyo, Satoh, Fumitoshi, Christian Rump, Lars, Vonend, Oliver, Willenberg, Holger S., Fuller, Peter J., Yang, Jun, Chee, Nicholas Yong Nian, Magill, Steven B., Shafigullina, Zulfiya, Quinkler, Marcus, Oliveras, Anna, Dun Wu, Kwan, Wu, Vin-Cent, Kratka, Zusana, Barbiero, Giulio, Battistel, Michele, Chang, Chin-Chen, Vanderriele, Paul-Emmanuel, and Pessina, Achille C.
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- 2019
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26. International multicenter survey on screening and confirmatory testing in primary aldosteronism.
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UCL - (SLuc) Service d'endocrinologie et de nutrition, Naruse, Mitsuhide, Murakami, Masanori, Katabami, Takuyuki, Kocjan, Tomaz, Parasiliti-Caprino, Mirko, Quinkler, Marcus, St-Jean, Matthieu, O'Toole, Sam, Ceccato, Filippo, Kraljevic, Ivana, Kastelan, Darko, Tsuiki, Mika, Deinum, Jaap, Torre, Edelmiro Menéndez, Puar, Troy, Markou, Athina, Piaditis, George, Laycock, Kate, Wada, Norio, Grytaas, Marianne Aardal, Kobayashi, Hiroki, Tanabe, Akiyo, Tong, Chin Voon, Gallego, Nuria Valdés, Gruber, Sven, Beuschlein, Felix, Kürzinger, Lydia, Sukor, Norlela, Azizan, Elena A B Aisha, Ragnarsson, Oskar, Nijhoff, Michiel F, Maiolino, Giuseppe, Dalmazi, Guido Di, Kalugina, Valentina, Lacroix, André, Furnica, Raluca-Maria, Suzuki, Tomoko, UCL - (SLuc) Service d'endocrinologie et de nutrition, Naruse, Mitsuhide, Murakami, Masanori, Katabami, Takuyuki, Kocjan, Tomaz, Parasiliti-Caprino, Mirko, Quinkler, Marcus, St-Jean, Matthieu, O'Toole, Sam, Ceccato, Filippo, Kraljevic, Ivana, Kastelan, Darko, Tsuiki, Mika, Deinum, Jaap, Torre, Edelmiro Menéndez, Puar, Troy, Markou, Athina, Piaditis, George, Laycock, Kate, Wada, Norio, Grytaas, Marianne Aardal, Kobayashi, Hiroki, Tanabe, Akiyo, Tong, Chin Voon, Gallego, Nuria Valdés, Gruber, Sven, Beuschlein, Felix, Kürzinger, Lydia, Sukor, Norlela, Azizan, Elena A B Aisha, Ragnarsson, Oskar, Nijhoff, Michiel F, Maiolino, Giuseppe, Dalmazi, Guido Di, Kalugina, Valentina, Lacroix, André, Furnica, Raluca-Maria, and Suzuki, Tomoko
- Abstract
OBJECTIVE: Primary aldosteronism (PA) is one of the most frequent causes of secondary hypertension. Although clinical practice guidelines recommend a diagnostic process, details of the steps remain incompletely standardized. DESIGN: In the present SCOT-PA survey, we have investigated the diversity of approaches utilized for each diagnostic step in different expert centers through a survey using Google questionnaires. A total of 33 centers from 3 continents participated. RESULTS: We demonstrated a prominent diversity in the conditions of blood sampling, assay methods for aldosterone and renin, and the methods and diagnostic cutoff for screening and confirmatory tests. The most standard measures were modification of antihypertensive medication and sitting posture for blood sampling, measurement of plasma aldosterone concentration (PAC) and active renin concentration by chemiluminescence enzyme immunoassay, a combination of aldosterone-to-renin ratio with PAC as an index for screening, and saline infusion test in a seated position for confirmatory testing. The cutoff values for screening and confirmatory testing showed significant variation among centers. CONCLUSIONS: Diversity of the diagnostic steps may lead to an inconsistent diagnosis of PA among centers and limit comparison of evidence for PA between different centers. We expect the impact of this diversity to be most prominent in patients with mild PA. The survey raises 2 issues: the need for standardization of the diagnostic process and revisiting the concept of mild PA. Further standardization of the diagnostic process/criteria will improve the quality of evidence and management of patients with PA.
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- 2023
27. Stepwise treatment of uncontrolled HyperTensioN (Stepwise-HTN): Study design of a cluster randomised controlled trial in primary care
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Cardiovasculaire Epi Team 5, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Kiliç, Birsen, Biermans, Marion C.J., Rutten, Frans H., Deinum, Jaap, Spiering, Wilko, van der Wel, Mark C., de Grauw, Wim J.C., Bots, Michiel L., Hollander, Monika, Cardiovasculaire Epi Team 5, HAG Hart- Vaatziekten, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, MS Interne Geneeskunde, Cardiovasculaire Epidemiologie, HAG Zorginnovatieonderzoek, Kiliç, Birsen, Biermans, Marion C.J., Rutten, Frans H., Deinum, Jaap, Spiering, Wilko, van der Wel, Mark C., de Grauw, Wim J.C., Bots, Michiel L., and Hollander, Monika
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- 2023
28. Adrenal vein sampling versus CT scan to determine treatment in primary aldosteronism: an outcome-based randomised diagnostic trial
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Dekkers, Tanja, Prejbisz, Aleksander, Kool, Leo J Schultze, Groenewoud, Hans J M M, Velema, Marieke, Spiering, Wilko, Kołodziejczyk-Kruk, Sylwia, Arntz, Mark, Kądziela, Jacek, Langenhuijsen, Johannes F, Kerstens, Michiel N, van den Meiracker, Anton H, van den Born, Bert-Jan, Sweep, Fred C G J, Hermus, Ad R M M, Januszewicz, Andrzej, Ligthart-Naber, Alike F, Makai, Peter, van der Wilt, Gert-Jan, Lenders, Jacques W M, and Deinum, Jaap
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- 2016
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29. Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
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Bliziotis, Nikolaos G., Kluijtmans, Leo A. J., Soto, Sebastian, Tinnevelt, Gerjen H., Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Engelke, Udo F. H., Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Prehn, Cornelia, Adamski, Jerzy, Januszewicz, Andrzej, Reincke, Martin, Fassnacht, Martin, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Wevers, Ron A., Jansen, Jeroen J., Deinum, Jaap, and Timmers, Henri J. L. M.
- Abstract
Purpose: Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors. Design: A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics. Methods: Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods. Results: Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected. Conclusions: Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
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- 2024
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30. International multicenter survey on screening and confirmatory testing in primary aldosteronism
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Naruse, Mitsuhide, primary, Murakami, Masanori, additional, Katabami, Takuyuki, additional, Kocjan, Tomaz, additional, Parasiliti-Caprino, Mirko, additional, Quinkler, Marcus, additional, St-Jean, Matthieu, additional, O'Toole, Sam, additional, Ceccato, Filippo, additional, Kraljevic, Ivana, additional, Kastelan, Darko, additional, Tsuiki, Mika, additional, Deinum, Jaap, additional, Torre, Edelmiro Menéndez, additional, Puar, Troy, additional, Markou, Athina, additional, Piaditis, George, additional, Laycock, Kate, additional, Wada, Norio, additional, Grytaas, Marianne Aardal, additional, Kobayashi, Hiroki, additional, Tanabe, Akiyo, additional, Tong, Chin Voon, additional, Gallego, Nuria Valdés, additional, Gruber, Sven, additional, Beuschlein, Felix, additional, Kürzinger, Lydia, additional, Sukor, Norlela, additional, Azizan, Elena A B Aisha, additional, Ragnarsson, Oskar, additional, Nijhoff, Michiel F, additional, Maiolino, Giuseppe, additional, Dalmazi, Guido Di, additional, Kalugina, Valentina, additional, Lacroix, André, additional, Furnica, Raluca Maria, additional, and Suzuki, Tomoko, additional
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- 2023
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31. Higher outdoor temperatures are progressively associated with lower blood pressure: a longitudinal study in 100,000 healthy individuals
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van den Hurk, Katja, de Kort, Wim L.A.M., Deinum, Jaap, and Atsma, Femke
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- 2015
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32. Congenital eyelid ptosis, decreased glomerular filtration, and orthostatic hypotension: Answers
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Wassenberg, Tessa, Willemsen, Michèl, Dijkman, Henry, Deinum, Jaap, and Monnens, Leo
- Subjects
Questions and answers ,Glomerular filtration rate -- Health aspects ,Orthostatic hypotension -- Research -- Diagnosis -- Care and treatment ,Blepharoptosis -- Research -- Diagnosis -- Care and treatment ,Health - Abstract
Author(s): Tessa Wassenberg [sup.1] , Michèl Willemsen [sup.1] , Henry Dijkman [sup.2] , Jaap Deinum [sup.3] , Leo Monnens [sup.4] Author Affiliations: (1) 0000 0004 0444 9382grid.10417.33Department of Neurology and [...]
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- 2017
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33. A Network Meta-Analysis of Clinical Management Strategies for Treatment-Resistant Hypertension: Making Optimal Use of the Evidence
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Makai, Peter, IntHout, Joanna, Deinum, Jaap, Jenniskens, Kevin, and Wilt, Gert Jan van der
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- 2017
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34. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial
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Schlaich, Markus P, primary, Bellet, Marc, additional, Weber, Michael A, additional, Danaietash, Parisa, additional, Bakris, George L, additional, Flack, John M, additional, Dreier, Roland F, additional, Sassi-Sayadi, Mouna, additional, Haskell, Lloyd P, additional, Narkiewicz, Krzysztof, additional, Wang, Ji-Guang, additional, Reid, Christopher, additional, Schlaich, Markus, additional, Katz, Ivor, additional, Ajani, Andrew, additional, Biswas, Sinjini, additional, Esler, Murray, additional, Elder, Grahame, additional, Roger, Simon, additional, Colquhoun, David, additional, Mooney, John, additional, De Backer, Tine, additional, Persu, Alexandre, additional, Chaumont, Martin, additional, Krzesinski, Jean-Marie, additional, Vanassche, Thomas, additional, Girard, Ginette, additional, Pliamm, Lew, additional, Schiffrin, Ernesto, additional, Merali, Fatima, additional, Dresser, George, additional, Vallee, Michel, additional, Jolly, Shivinder, additional, Chow, Stephen, additional, Wang, Jiguang, additional, Mu, Jianjun, additional, Yu, Jing, additional, Yuan, Hong, additional, Feng, Yingqing, additional, Zhang, Xin, additional, Xie, Jianhong, additional, Lin, Ling, additional, Soucek, Miroslav, additional, Widimsky, Jiri, additional, Cifkova, Renata, additional, Vaclavik, Jan, additional, Ullrych, Martin, additional, Lukac, Martin, additional, Rychlik, Ivan, additional, Guldager Lauridsen, Thomas, additional, Kantola, Ilkka, additional, Taurio, Jyrki, additional, Ukkola, Olavi, additional, Ormezzano, Olivier, additional, Gosse, Philippe, additional, Azizi, Michel, additional, Courand, Pierre-Yves, additional, Delsart, Pascal, additional, Tartiere, Jean Michel, additional, Mahfoud, Felix, additional, Schmieder, Roland, additional, Stegbauer, Johannes, additional, Lurz, Philipp, additional, Koziolek, Michael, additional, Ott, Christian, additional, Toursarkissian, Nicole, additional, Tsioufis, Konstantinos, additional, Kyfnidis, Konstantinos, additional, Manolis, Athanasios, additional, Patsilinakos, Sotirios, additional, Zebekakis, Pantelis, additional, Karavidas, Apostolos, additional, Denes, Pall, additional, Bezzegh, Katalin, additional, Zsom, Marianna, additional, Kovacs, Laszlo, additional, Sharabi, Yehonatan, additional, Elias, Mazen, additional, Sukholutsky, Ivetta, additional, Yosefy, Chaim, additional, Kenis, Irina, additional, Atar, Shaul, additional, Volpe, Massimo, additional, Maria Lorenza, Muiesan, additional, Taddei, Stefano, additional, Grassi, Guido, additional, Veglio, Franco, additional, Son, Jung Woo, additional, Kim, Jang-Young, additional, Park, Joong-Il, additional, Lee, Chang Hoon, additional, Lee, Hae-Young, additional, Raugaliene, Rasa, additional, Marcinkeviciene, Jolanta Elena, additional, Kavaliauskiene, Roma, additional, Deinum, Jaap, additional, Kroon, Abraham, additional, van den Born, Bert-Jan, additional, Januszewicz, Andrzej, additional, Tykarski, Andrzej, additional, Walczewska, Jolanta, additional, Gaciong, Zbigniew, additional, Wiecek, Andrzej, additional, Chrostowska, Marzena, additional, Kleinrok, Andrzej, additional, Krekora, Jan, additional, Kania, Grzegorz, additional, Podrazka-Szczepaniak, Anna, additional, Golawski, Cezary, additional, Podziewski, Maciej, additional, Kaczmarek, Barbara, additional, Skoczylas, Grzegorz, additional, Wilkolaski, Andrzej, additional, Wozniak, Iwona, additional, Janik-Palazzolo, Marzena, additional, Rewerska, Barbara, additional, Konradi, Aleksandra, additional, Shvarts, Yuriy, additional, Pecherina, Tamara, additional, Nikolaev, Konstantin, additional, Liudmila, Gapon, additional, Orlikova, Olga, additional, Mordovin, Viktor, additional, Petrochenkova, Natalia, additional, Kamalov, Gadel, additional, Kosmacheva, Elena, additional, Tyrenko, Vadim, additional, Gorbunov, Vladimir, additional, Obrezan, Andrey, additional, Supryadkina, Tatiana, additional, Ler, Irina, additional, Kotenko, Oleg, additional, Kuzin, Anatoly, additional, Martínez García, Fernando, additional, Redon, Josep, additional, Oliveras, Anna, additional, Beltran Romero, Luis, additional, Shatylo, Valerii, additional, Rudenko, Leonid, additional, Bazylevych, Andriy, additional, Rudyk, Yurii, additional, Karpenko, Oleksandr, additional, Stanislavchuk, Mykola, additional, Tseluyko, Vira, additional, Kushnir, Mykola, additional, Asanov, Ervin, additional, Sirenko, Yuriy, additional, Yagensky, Andriy, additional, Collier, David, additional, Gupta, Pankaj, additional, Webb, David, additional, MacLeod, Mary, additional, McLay, James, additional, Peace, Aaron, additional, Arora, Samir, additional, Buchanan, Patricia, additional, Harris, Robert, additional, Degarmo, Ronald, additional, Guillen, Mario, additional, Karns, Adam, additional, Neutel, Joel, additional, Paliwal, Yogesh, additional, Pettis, Karlton, additional, Toth, Phillip D., additional, Wayne, Jeffrey M., additional, Butcher, Michael Bain, additional, Diller, Phillip M., additional, Oparil, Suzanne, additional, Calhoun, David, additional, Brautigam, Donald, additional, Flack, John, additional, Goldman, Jesse M., additional, Rashidi, Arash, additional, Aslam, Nabeel, additional, Haley, William, additional, Andrawis, Nabil, additional, Lang, Brian, additional, Miller, Randy, additional, Powell, James, additional, Dewhurst, Robert, additional, Pritchard, James, additional, Khanna, Dinesh, additional, Tang, Dennis, additional, Gabra, Nashwa, additional, Park, Jean, additional, Jones, Conigliaro, additional, Scott, Cranford, additional, Luna, Blanca, additional, Mussaji, Murtaza, additional, Bhagwat, Ravi, additional, Bauer, Michael, additional, McGinty, John, additional, Nambiar, Rajesh, additional, Sangrigoli, Renee, additional, Davis, William Ross, additional, Eaves, William, additional, McGrew, Frank, additional, Awad, Ahmed, additional, Bolster, Eric, additional, Scott, David, additional, Kalirao, Paramjit, additional, Dabel, Pascal, additional, Calhoun, Wesley, additional, Gouge, Steven, additional, Warren, Mark, additional, Lawrence, Mary Katherine, additional, Jamal, Aamir, additional, El-Shahawy, Mohamed, additional, Mercado, Carlos, additional, Kumar, Jayant, additional, Velasquez-Mieyer, Pedro, additional, Busch, Robert, additional, Lewis, Todd, additional, and Rich, Lisa, additional
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- 2022
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35. Changes of the CYP11B2 Expressing Zona Glomerulosa in Human Adrenals From Birth to 40 Years of Age
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van de Wiel, Elle, primary, Chaman Baz, Amir-Hossein, additional, Küsters, Benno, additional, Mukai, Kuniaki, additional, van Bonzel, Lidia, additional, van Erp, Merijn, additional, Deinum, Jaap, additional, and Langenhuijsen, Johan, additional
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- 2022
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36. Machine learning for classification of hypertension subtypes using multi-omics: A multi-centre, retrospective, data-driven study
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Reel, Parminder S., primary, Reel, Smarti, additional, van Kralingen, Josie C., additional, Langton, Katharina, additional, Lang, Katharina, additional, Erlic, Zoran, additional, Larsen, Casper K., additional, Amar, Laurence, additional, Pamporaki, Christina, additional, Mulatero, Paolo, additional, Blanchard, Anne, additional, Kabat, Marek, additional, Robertson, Stacy, additional, MacKenzie, Scott M., additional, Taylor, Angela E., additional, Peitzsch, Mirko, additional, Ceccato, Filippo, additional, Scaroni, Carla, additional, Reincke, Martin, additional, Kroiss, Matthias, additional, Dennedy, Michael C., additional, Pecori, Alessio, additional, Monticone, Silvia, additional, Deinum, Jaap, additional, Rossi, Gian Paolo, additional, Lenzini, Livia, additional, McClure, John D., additional, Nind, Thomas, additional, Riddell, Alexandra, additional, Stell, Anthony, additional, Cole, Christian, additional, Sudano, Isabella, additional, Prehn, Cornelia, additional, Adamski, Jerzy, additional, Gimenez-Roqueplo, Anne-Paule, additional, Assié, Guillaume, additional, Arlt, Wiebke, additional, Beuschlein, Felix, additional, Eisenhofer, Graeme, additional, Davies, Eleanor, additional, Zennaro, Maria-Christina, additional, and Jefferson, Emily, additional
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- 2022
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37. Effect of Antihypertensive Medication on Cerebral Small Vessel Disease: A Systematic Review and Meta-Analysis
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van Middelaar, Tessa, Argillander, Tanja E., Schreuder, Floris H.B.M., Deinum, Jaap, Richard, Edo, and Klijn, Catharina J.M.
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- 2018
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38. Adrenal Vein Sampling Is the Preferred Method to Select Patients With Primary Aldosteronism for Adrenalectomy: Con Side of the Argument
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Deinum, Jaap, Prejbisz, Aleksander, Lenders, Jacques W.M., and van der Wilt, Gert Jan
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- 2018
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39. Quality of Life in Primary Aldosteronism: A Comparative Effectiveness Study of Adrenalectomy and Medical Treatment
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Velema, Marieke, Dekkers, Tanja, Hermus, Ad, Timmers, Henri, Lenders, Jacques, Groenewoud, Hans, Schultze Kool, Leo, Langenhuijsen, Johan, Prejbisz, Aleksander, van der Wilt, Gert-Jan, and Deinum, Jaap
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- 2018
40. Healthcare Technology Assessment of Medical Imaging Technology
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Deinum, Jaap, primary, Restovic, Gabriela, additional, Makai, Peter, additional, van der Wilt, Gert Jan, additional, and Colom, Laura Sampietro, additional
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- 2017
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41. Predicting Hypertension Subtypes with Machine Learning Using Targeted Metabolites and Their Ratios
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Reel, Smarti, primary, Reel, Parminder S., additional, Erlic, Zoran, additional, Amar, Laurence, additional, Pecori, Alessio, additional, Larsen, Casper K., additional, Tetti, Martina, additional, Pamporaki, Christina, additional, Prehn, Cornelia, additional, Adamski, Jerzy, additional, Prejbisz, Aleksander, additional, Ceccato, Filippo, additional, Scaroni, Carla, additional, Kroiss, Matthias, additional, Dennedy, Michael C., additional, Deinum, Jaap, additional, Eisenhofer, Graeme, additional, Langton, Katharina, additional, Mulatero, Paolo, additional, Reincke, Martin, additional, Rossi, Gian Paolo, additional, Lenzini, Livia, additional, Davies, Eleanor, additional, Gimenez-Roqueplo, Anne-Paule, additional, Assié, Guillaume, additional, Blanchard, Anne, additional, Zennaro, Maria-Christina, additional, Beuschlein, Felix, additional, and Jefferson, Emily R., additional
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- 2022
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42. CXCR4-directed [68Ga]Ga-PentixaFor PET/CT versus adrenal vein sampling performance: a study protocol for a randomised two-step controlled diagnoStic Trial Ultimately comparing hypertenSion outcome in primary aldosteronism (CASTUS)
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Chaman Baz, Amir Hossein, primary, van de Wiel, Elle, additional, Groenewoud, Hans, additional, Arntz, Mark, additional, Gotthardt, Martin, additional, Deinum, Jaap, additional, and Langenhuijsen, Johan, additional
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- 2022
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43. Preanalytical Pitfalls in Untargeted Plasma Nuclear Magnetic Resonance Metabolomics of Endocrine Hypertension
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Bliziotis, Nikolaos G., primary, Kluijtmans, Leo A. J., additional, Tinnevelt, Gerjen H., additional, Reel, Parminder, additional, Reel, Smarti, additional, Langton, Katharina, additional, Robledo, Mercedes, additional, Pamporaki, Christina, additional, Pecori, Alessio, additional, Van Kralingen, Josie, additional, Tetti, Martina, additional, Engelke, Udo F. H., additional, Erlic, Zoran, additional, Engel, Jasper, additional, Deutschbein, Timo, additional, Nölting, Svenja, additional, Prejbisz, Aleksander, additional, Richter, Susan, additional, Adamski, Jerzy, additional, Januszewicz, Andrzej, additional, Ceccato, Filippo, additional, Scaroni, Carla, additional, Dennedy, Michael C., additional, Williams, Tracy A., additional, Lenzini, Livia, additional, Gimenez-Roqueplo, Anne-Paule, additional, Davies, Eleanor, additional, Fassnacht, Martin, additional, Remde, Hanna, additional, Eisenhofer, Graeme, additional, Beuschlein, Felix, additional, Kroiss, Matthias, additional, Jefferson, Emily, additional, Zennaro, Maria-Christina, additional, Wevers, Ron A., additional, Jansen, Jeroen J., additional, Deinum, Jaap, additional, and Timmers, Henri J. L. M., additional
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- 2022
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44. Preanalytical Pitfalls in Untargeted Plasma Nuclear Magnetic Resonance Metabolomics of Endocrine Hypertension
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Bliziotis, Nikolaos G., Kluijtmans, Leo A.J., Tinnevelt, Gerjen H., Reel, Parminder, Reel, Smarti, Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Pecori, Alessio, Van Kralingen, Josie, Tetti, Martina, Engelke, Udo F.H., Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Adamski, Jerzy, Januszewicz, Andrzej, Ceccato, Filippo, Scaroni, Carla, Dennedy, Michael C., Williams, Tracy A., Lenzini, Livia, Gimenez-Roqueplo, Anne Paule, Davies, Eleanor, Fassnacht, Martin, Remde, Hanna, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Jefferson, Emily, Zennaro, Maria Christina, Wevers, Ron A., Jansen, Jeroen J., Deinum, Jaap, Timmers, Henri J.L.M., Bliziotis, Nikolaos G., Kluijtmans, Leo A.J., Tinnevelt, Gerjen H., Reel, Parminder, Reel, Smarti, Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Pecori, Alessio, Van Kralingen, Josie, Tetti, Martina, Engelke, Udo F.H., Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Adamski, Jerzy, Januszewicz, Andrzej, Ceccato, Filippo, Scaroni, Carla, Dennedy, Michael C., Williams, Tracy A., Lenzini, Livia, Gimenez-Roqueplo, Anne Paule, Davies, Eleanor, Fassnacht, Martin, Remde, Hanna, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Jefferson, Emily, Zennaro, Maria Christina, Wevers, Ron A., Jansen, Jeroen J., Deinum, Jaap, and Timmers, Henri J.L.M.
- Abstract
Despite considerable morbidity and mortality, numerous cases of endocrine hypertension (EHT) forms, including primary aldosteronism (PA), pheochromocytoma and functional paraganglioma (PPGL), and Cushing’s syndrome (CS), remain undetected. We aimed to establish signatures for the different forms of EHT, investigate potentially confounding effects and establish unbiased disease biomarkers. Plasma samples were obtained from 13 biobanks across seven countries and analyzed using untargeted NMR metabolomics. We compared unstratified samples of 106 PHT patients to 231 EHT patients, including 104 PA, 94 PPGL and 33 CS patients. Spectra were subjected to a multivariate statistical comparison of PHT to EHT forms and the associated signatures were obtained. Three approaches were applied to investigate and correct confounding effects. Though we found signatures that could separate PHT from EHT forms, there were also key similarities with the signatures of sample center of origin and sample age. The study design restricted the applicability of the corrections employed. With the samples that were available, no biomarkers for PHT vs. EHT could be identified. The complexity of the confounding effects, evidenced by their robustness to correction approaches, highlighted the need for a consensus on how to deal with variabilities probably attributed to preanalytical factors in retrospective, multicenter metabolomics studies.
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- 2022
45. Dual endothelin antagonist aprocitentan for resistant hypertension (PRECISION): a multicentre, blinded, randomised, parallel-group, phase 3 trial
- Author
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Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, Rich, Lisa, Schlaich, M, Bellet, M, Weber, M, Danaietash, P, Bakris, G, Flack, J, Dreier, R, Sassi-Sayadi, M, Haskell, L, Narkiewicz, K, Wang, J, Reid, C, Katz, I, Ajani, A, Biswas, S, Esler, M, Elder, G, Roger, S, Colquhoun, D, Mooney, J, De Backer, T, Persu, A, Chaumont, M, Krzesinski, J, Vanabsche, T, Girard, G, Pliamm, L, Schiffrin, E, Merali, F, Dresser, G, Vallee, M, Jolly, S, Chow, S, Mu, J, Yu, J, Yuan, H, Feng, Y, Zhang, X, Xie, J, Lin, L, Soucek, M, Widimsky, J, Cifkova, R, Vaclavik, J, Ullrych, M, Lukac, M, Rychlik, I, Guldager Lauridsen, T, Kantola, I, Taurio, J, Ukkola, O, Ormezzano, O, Gosse, P, Azizi, M, Courand, P, Delsart, P, Tartiere, J, Mahfoud, F, Schmieder, R, Stegbauer, J, Lurz, P, Koziolek, M, Ott, C, Toursarkissian, N, Tsioufis, K, Kyfnidis, K, Manolis, A, Patsilinakos, S, Zebekakis, P, Karavidas, A, Denes, P, Bezzegh, K, Zsom, M, Kovacs, L, Sharabi, Y, Elias, M, Sukholutsky, I, Yosefy, C, Kenis, I, Atar, S, Volpe, M, Lorenza, M, Taddei, S, Grassi, G, Veglio, F, Son, J, Kim, J, Park, J, Lee, C, Lee, H, Raugaliene, R, Marcinkeviciene, J, Kavaliauskiene, R, Deinum, J, Kroon, A, van den Born, B, Januszewicz, A, Tykarski, A, Walczewska, J, Gaciong, Z, Wiecek, A, Chrostowska, M, Kleinrok, A, Krekora, J, Kania, G, Podrazka-Szczepaniak, A, Golawski, C, Podziewski, M, Kaczmarek, B, Skoczylas, G, Wilkolaski, A, Wozniak, I, Janik-Palazzolo, M, Rewerska, B, Konradi, A, Shvarts, Y, Pecherina, T, Nikolaev, K, Liudmila, G, Orlikova, O, Mordovin, V, Petrochenkova, N, Kamalov, G, Kosmacheva, E, Tyrenko, V, Gorbunov, V, Obrezan, A, Supryadkina, T, Ler, I, Kotenko, O, Kuzin, A, Martinez, F, Redon, J, Oliveras, A, Beltran Romero, L, Shatylo, V, Rudenko, L, Bazylevych, A, Rudyk, Y, Karpenko, O, Stanislavchuk, M, Tseluyko, V, Kushnir, M, Asanov, E, Sirenko, Y, Yagensky, A, Collier, D, Gupta, P, Webb, D, Macleod, M, Mclay, J, Peace, A, Arora, S, Buchanan, P, Harris, R, Degarmo, R, Guillen, M, Karns, A, Neutel, J, Paliwal, Y, Pettis, K, Toth, P, Wayne, J, Butcher, B, Diller, P, Oparil, S, Calhoun, D, Brautigam, D, Goldman, J, Rashidi, A, Aslam, N, Haley, W, Andrawis, N, Lang, B, Miller, R, Powell, J, Dewhurst, R, Pritchard, J, Khanna, D, Tang, D, Gabra, N, Jones, C, Scott, C, Luna, B, Mussaji, M, Bhagwat, R, Bauer, M, Mcginty, J, Nambiar, R, Sangrigoli, R, Ross Davis, W, Eaves, W, Mcgrew, F, Awad, A, Bolster, E, Scott, D, Kalirao, P, Dabel, P, Calhoun, W, Gouge, S, Warren, M, Lawrence, M, Jamal, A, El-Shahawy, M, Mercado, C, Kumar, J, Velasquez-Mieyer, P, Busch, R, Lewis, T, Rich, L, Schlaich, Markus P, Bellet, Marc, Weber, Michael A, Danaietash, Parisa, Bakris, George L, Flack, John M, Dreier, Roland F, Sassi-Sayadi, Mouna, Haskell, Lloyd P, Narkiewicz, Krzysztof, Wang, Ji-Guang, Reid, Christopher, Schlaich, Markus, Katz, Ivor, Ajani, Andrew, Biswas, Sinjini, Esler, Murray, Elder, Grahame, Roger, Simon, Colquhoun, David, Mooney, John, De Backer, Tine, Persu, Alexandre, Chaumont, Martin, Krzesinski, Jean-Marie, Vanabsche, Thomas, Girard, Ginette, Pliamm, Lew, Schiffrin, Ernesto, Merali, Fatima, Dresser, George, Vallee, Michel, Jolly, Shivinder, Chow, Stephen, Wang, Jiguang, Mu, Jianjun, Yu, Jing, Yuan, Hong, Feng, Yingqing, Zhang, Xin, Xie, Jianhong, Lin, Ling, Soucek, Miroslav, Widimsky, Jiri, Cifkova, Renata, Vaclavik, Jan, Ullrych, Martin, Lukac, Martin, Rychlik, Ivan, Guldager Lauridsen, Thomas, Kantola, Ilkka, Taurio, Jyrki, Ukkola, Olavi, Ormezzano, Olivier, Gosse, Philippe, Azizi, Michel, Courand, Pierre-Yves, Delsart, Pascal, Tartiere, Jean Michel, Mahfoud, Felix, Schmieder, Roland, Stegbauer, Johannes, Lurz, Philipp, Koziolek, Michael, Ott, Christian, Toursarkissian, Nicole, Tsioufis, Konstantinos, Kyfnidis, Konstantinos, Manolis, Athanasios, Patsilinakos, Sotirios, Zebekakis, Pantelis, Karavidas, Apostolos, Denes, Pall, Bezzegh, Katalin, Zsom, Marianna, Kovacs, Laszlo, Sharabi, Yehonatan, Elias, Mazen, Sukholutsky, Ivetta, Yosefy, Chaim, Kenis, Irina, Atar, Shaul, Volpe, Massimo, Lorenza, Muiesan Maria, Taddei, Stefano, Grassi, Guido, Veglio, Franco, Son, Jung Woo, Kim, Jang-Young, Park, Joong-Il, Lee, Chang Hoon, Lee, Hae-Young, Raugaliene, Rasa, Marcinkeviciene, Jolanta Elena, Kavaliauskiene, Roma, Deinum, Jaap, Kroon, Abraham, van den Born, Bert-Jan, Januszewicz, Andrzej, Tykarski, Andrzej, Walczewska, Jolanta, Gaciong, Zbigniew, Wiecek, Andrzej, Chrostowska, Marzena, Kleinrok, Andrzej, Krekora, Jan, Kania, Grzegorz, Podrazka-Szczepaniak, Anna, Golawski, Cezary, Podziewski, Maciej, Kaczmarek, Barbara, Skoczylas, Grzegorz, Wilkolaski, Andrzej, Wozniak, Iwona, Janik-Palazzolo, Marzena, Rewerska, Barbara, Konradi, Alexandra, Shvarts, Yuriy, Pecherina, Tamara, Nikolaev, Konstantin, Liudmila, Gapon, Orlikova, Olga, Mordovin, Viktor, Petrochenkova, Natalia, Kamalov, Gadel, Kosmacheva, Elena, Tyrenko, Vadim, Gorbunov, Vladimir, Obrezan, Andrey, Supryadkina, Tatiana, Ler, Irina, Kotenko, Oleg, Kuzin, Anatoly, Martinez, Fernando, Redon, Josep, Oliveras, Anna, Beltran Romero, Luis, Shatylo, Valerii, Rudenko, Leonid, Bazylevych, Andriiy, Rudyk, Yurii, Karpenko, Oleksandr, Stanislavchuk, Mykola, Tseluyko, Vira, Kushnir, Mykola, Asanov, Ervin, Sirenko, Yuriy, Yagensky, Andriy, Collier, David, Gupta, Pankaj, Webb, David, MacLeod, Mary, McLay, James, Peace, Aaron, Arora, Samir, Buchanan, Patricia, Harris, Robert, Degarmo, Ronald, Guillen, Mario, Karns, Adam, Neutel, Joel, Paliwal, Yogesh, Pettis, Karlton, Toth, Phillip D., Wayne, Jeffrey M., Butcher, Bain, Diller, Phillip M., Oparil, Suzanne, Calhoun, David, Brautigam, Donald, Flack, John, Goldman, Jesse M., Rashidi, Arash, Aslam, Nabeel, Haley, William, Andrawis, Nabil, Lang, Brian, Miller, Randy, Powell, James, Dewhurst, Robert, Pritchard, James, Khanna, Dinesh, Tang, Dennis, Gabra, Nashwa, Park, Jean, Jones, Conigliaro, Scott, Cranford, Luna, Blanca, Mussaji, Murtaza, Bhagwat, Ravi, Bauer, Michael, McGinty, John, Nambiar, Rajesh, Sangrigoli, Renee, Ross Davis, William, Eaves, William, McGrew, Frank, Awad, Ahmed, Bolster, Eric, Scott, David, Kalirao, Paramjit, Dabel, Pascal, Calhoun, Wesley, Gouge, Steven, Warren, Mark, Lawrence, Mary Katherine, Jamal, Aamir, El-Shahawy, Mohamed, Mercado, Carlos, Kumar, Jayant, Velasquez-Mieyer, Pedro, Busch, Robert, Lewis, Todd, and Rich, Lisa
- Abstract
Background: Resistant hypertension is associated with increased cardiovascular risk. The endothelin pathway has been implicated in the pathogenesis of hypertension, but it is currently not targeted therapeutically, thereby leaving this relevant pathophysiological pathway unopposed with currently available drugs. The aim of the study was to assess the blood pressure lowering efficacy of the dual endothelin antagonist aprocitentan in patients with resistant hypertension. Methods: PRECISION was a multicentre, blinded, randomised, parallel-group, phase 3 study, which was done in hospitals or research centres in Europe, North America, Asia, and Australia. Patients were eligible for randomisation if their sitting systolic blood pressure was 140 mm Hg or higher despite taking standardised background therapy consisting of three antihypertensive drugs, including a diuretic. The study consisted of three sequential parts: part 1 was the 4-week double-blind, randomised, and placebo-controlled part, in which patients received aprocitentan 12·5 mg, aprocitentan 25 mg, or placebo in a 1:1:1 ratio; part 2 was a 32-week single (patient)-blind part, in which all patients received aprocitentan 25 mg; and part 3 was a 12-week double-blind, randomised, and placebo-controlled withdrawal part, in which patients were re-randomised to aprocitentan 25 mg or placebo in a 1:1 ratio. The primary and key secondary endpoints were changes in unattended office systolic blood pressure from baseline to week 4 and from withdrawal baseline to week 40, respectively. Secondary endpoints included 24-h ambulatory blood pressure changes. The study is registered on ClinicalTrials.gov, NCT03541174. Findings: The PRECISION study was done from June 18, 2018, to April 25, 2022. 1965 individuals were screened and 730 were randomly assigned. Of these 730 patients, 704 (96%) completed part 1 of the study; of these, 613 (87%) completed part 2 and, of these, 577 (94%) completed part 3 of the study. The least square m
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- 2022
46. Pre- versus post-operative untargeted plasma nuclear magnetic resonance spectroscopy metabolomics of pheochromocytoma and paraganglioma
- Author
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Bliziotis, Nikolaos G; https://orcid.org/0000-0001-7775-6613, Kluijtmans, Leo A J, Soto, Sebastian, Tinnevelt, Gerjen H, Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Engelke, Udo F H, Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Prehn, Cornelia, Adamski, Jerzy, Januszewicz, Andrzej, Reincke, Martin, Fassnacht, Martin, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Wevers, Ron A, Jansen, Jeroen J, Deinum, Jaap, Timmers, Henri J L M; https://orcid.org/0000-0002-1208-5748, Bliziotis, Nikolaos G; https://orcid.org/0000-0001-7775-6613, Kluijtmans, Leo A J, Soto, Sebastian, Tinnevelt, Gerjen H, Langton, Katharina, Robledo, Mercedes, Pamporaki, Christina, Engelke, Udo F H, Erlic, Zoran, Engel, Jasper, Deutschbein, Timo, Nölting, Svenja, Prejbisz, Aleksander, Richter, Susan, Prehn, Cornelia, Adamski, Jerzy, Januszewicz, Andrzej, Reincke, Martin, Fassnacht, Martin, Eisenhofer, Graeme, Beuschlein, Felix, Kroiss, Matthias, Wevers, Ron A, Jansen, Jeroen J, Deinum, Jaap, and Timmers, Henri J L M; https://orcid.org/0000-0002-1208-5748
- Abstract
PURPOSE Pheochromocytomas and Paragangliomas (PPGL) result in chronic catecholamine excess and serious health complications. A recent study obtained a metabolic signature in plasma from PPGL patients; however, its targeted nature may have generated an incomplete picture and a broader approach could provide additional insights. We aimed to characterize the plasma metabolome of PPGL patients before and after surgery, using an untargeted approach, and to broaden the scope of the investigated metabolic impact of these tumors. DESIGN A cohort of 36 PPGL patients was investigated. Blood plasma samples were collected before and after surgical tumor removal, in association with clinical and tumor characteristics. METHODS Plasma samples were analyzed using untargeted nuclear magnetic resonance (NMR) spectroscopy metabolomics. The data were evaluated using a combination of uni- and multi-variate statistical methods. RESULTS Before surgery, patients with a nonadrenergic tumor could be distinguished from those with an adrenergic tumor based on their metabolic profiles. Tyrosine levels were significantly higher in patients with high compared to those with low BMI. Comparing subgroups of pre-operative samples with their post-operative counterparts, we found a metabolic signature that included ketone bodies, glucose, organic acids, methanol, dimethyl sulfone and amino acids. Three signals with unclear identities were found to be affected. CONCLUSIONS Our study suggests that the pathways of glucose and ketone body homeostasis are affected in PPGL patients. BMI-related metabolite levels were also found to be altered, potentially linking muscle atrophy to PPGL. At baseline, patient metabolomes could be discriminated based on their catecholamine phenotype.
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- 2022
47. Plasma galectin-3 concentrations in patients with primary aldosteronism
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van den Berg, T.N.A. (Daniëlle), Meijers, Wouter C., Donders, A. Rogier T., Van Herwaarden, Antonius E., Rongen, Gerard A., de Boer, Rudolf A., Deinum, Jaap, and Riksen, Niels P.
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- 2017
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48. Image Registration of Cone-Beam Computer Tomography and Preprocedural Computer Tomography Aids in Localization of Adrenal Veins and Decreasing Radiation Dose in Adrenal Vein Sampling
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Busser, Wendy M. H., Arntz, Mark J., Jenniskens, Sjoerd F. M., Deinum, Jaap, Hoogeveen, Yvonne L., de Lange, Frank, and Schultze Kool, Leo J.
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- 2015
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49. Preanalytical Considerations and Outpatient Versus Inpatient Tests of Plasma Metanephrines to Diagnose Pheochromocytoma
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Pommer, Georg, primary, Pamporaki, Christina, additional, Peitzsch, Mirko, additional, Remde, Hanna, additional, Deutschbein, Timo, additional, Nölting, Svenja, additional, Müller, Lisa Marie, additional, Braun, Leah, additional, Gruber, Sven, additional, Pecori, Alessio, additional, Hampson, Stephanie, additional, Davies, Eleanor, additional, Stell, Anthony, additional, Rossi, Gian Paolo, additional, Lenzini, Livia, additional, Ceccato, Filippo, additional, Timmers, Henri J L M, additional, Deinum, Jaap, additional, Amar, Laurence, additional, Blanchard, Anne, additional, Baron, Stephanie, additional, Fassnacht, Martin, additional, Dobrowolski, Piotr, additional, Januszewicz, Andrzej, additional, Zennaro, Maria-Christina, additional, Prejbisz, Aleksander, additional, and Eisenhofer, Graeme, additional
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- 2022
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50. HIGHER SYSTOLIC BLOOD PRESSURE IN FEMALE PATIENTS WITH MITOCHONDRIAL DISEASE
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Deinum, Jaap, primary, Viering, Daan, additional, Van Borselen, Marjolein D, additional, Bindels, René, additional, De Baaij, Jeroen, additional, and Janssen, Mirian Ch, additional
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- 2022
- Full Text
- View/download PDF
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