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1. Management of mild degenerative cervical myelopathy and asymptomatic spinal cord compression: an international survey.

Author

Brannigan, Jamie, Davies, Benjamin, Mowforth, Oliver, Yurac, Ratko, Kumar, Vishal, Dejaegher, Joost, Zamorano, Juan, Murphy, Rory, Tripathi, Manjul, Anderson, David, Harrop, James, Molliqaj, Granit, Wynne-Jones, Guy, Arbatin, Jose, Kato, So, Ito, Manabu, Wilson, Jefferson, Romelean, Ronie, Dea, Nicolas, Graves, Daniel, Tessitore, Enrico, Nouri, Aria, and Martin, Allan

Subjects
Humans, Spinal Cord Compression, Cross-Sectional Studies, Magnetic Resonance Imaging, Spinal Cord Injuries, Spinal Cord Diseases, Cervical Vertebrae
Abstract

STUDY DESIGN: Cross-sectional survey. OBJECTIVE: Currently there is limited evidence and guidance on the management of mild degenerative cervical myelopathy (DCM) and asymptomatic spinal cord compression (ASCC). Anecdotal evidence suggest variance in clinical practice. The objectives of this study were to assess current practice and to quantify the variability in clinical practice. METHODS: Spinal surgeons and some additional health professionals completed a web-based survey distributed by email to members of AO Spine and the Cervical Spine Research Society (CSRS) North American Society. Questions captured experience with DCM, frequency of DCM patient encounters, and standard of practice in the assessment of DCM. Further questions assessed the definition and management of mild DCM, and the management of ASCC. RESULTS: A total of 699 respondents, mostly surgeons, completed the survey. Every world region was represented in the responses. Half (50.1%, n = 359) had greater than 10 years of professional experience with DCM. For mild DCM, standardised follow-up for non-operative patients was reported by 488 respondents (69.5%). Follow-up included a heterogeneous mix of investigations, most often at 6-month intervals (32.9%, n = 158). There was some inconsistency regarding which clinical features would cause a surgeon to counsel a patient towards surgery. Practice for ASCC aligned closely with mild DCM. Finally, there were some contradictory definitions of mild DCM provided in the form of free text. CONCLUSIONS: Professionals typically offer outpatient follow up for patients with mild DCM and/or asymptomatic ASCC. However, what this constitutes varies widely. Further research is needed to define best practice and support patient care.

Published
2024

2. CCL21-CCR7 signaling promotes microglia/macrophage recruitment and chemotherapy resistance in glioblastoma

Author

Geraldo, Luiz Henrique, Garcia, Celina, Xu, Yunling, Leser, Felipe Saceanu, Grimaldi, Izabella, de Camargo Magalhães, Eduardo Sabino, Dejaegher, Joost, Solie, Lien, Pereira, Cláudia Maria, Correia, Ana Helena, De Vleeschouwer, Steven, Tavitian, Bertrand, Canedo, Nathalie Henriques Silva, Mathivet, Thomas, Thomas, Jean-Leon, Eichmann, Anne, and Lima, Flavia Regina Souza

Published
2023
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3. Management of mild degenerative cervical myelopathy and asymptomatic spinal cord compression: an international survey

Author

Brannigan, Jamie F. M., primary, Davies, Benjamin M., additional, Mowforth, Oliver D., additional, Yurac, Ratko, additional, Kumar, Vishal, additional, Dejaegher, Joost, additional, Zamorano, Juan J., additional, Murphy, Rory K. J., additional, Tripathi, Manjul, additional, Anderson, David B., additional, Harrop, James, additional, Molliqaj, Granit, additional, Wynne-Jones, Guy, additional, Arbatin, Jose Joefrey F., additional, Kato, So, additional, Ito, Manabu, additional, Wilson, Jefferson, additional, Romelean, Ronie, additional, Dea, Nicolas, additional, Graves, Daniel, additional, Tessitore, Enrico, additional, Martin, Allan R., additional, and Nouri, Aria, additional

Published
2023
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4. SLIT2/ROBO signaling in tumor-associated microglia and macrophages drives glioblastoma immunosuppression and vascular dysmorphia

Author

Geraldo, Luiz H., Xu, Yunling, Jacob, Laurent, Pibouin-Fragner, Laurence, Rao, Rohit, Maissa, Nawal, Verreault, Maite, Lemaire, Nolwenn, Knosp, Camille, Lesaffre, Corinne, Daubon, Thomas, Dejaegher, Joost, Solie, Lien, Rudewicz, Justine, Viel, Thomas, Tavitian, Bertrand, De Vleeschouwer, Steven, Sanson, Marc, Bikfalvi, Andreas, Idbaih, Ahmed, Lu, Q. Richard, Lima, Flavia R.S., Thomas, Jean-Leon, Eichmann, Anne, and Mathivet, Thomas

Subjects
Oncology, Experimental, Gene expression -- Research, Polypeptides -- Genetic aspects -- Health aspects, Immune response -- Genetic aspects -- Health aspects, Brain tumors -- Genetic aspects -- Development and progression, Membrane proteins -- Genetic aspects -- Health aspects, Glioblastoma multiforme -- Genetic aspects -- Development and progression, Cellular signal transduction -- Research, Macrophages -- Genetic aspects -- Health aspects, Cancer -- Research, Blood circulation disorders -- Genetic aspects -- Development and progression, Health care industry
Abstract

SLIT2 is a secreted polypeptide that guides migration of cells expressing Roundabout 1 and 2 (ROBO1 and ROBO2) receptors. Herein, we investigated SLIT2/ROBO signaling effects in gliomas. In patients with glioblastoma (GBM), SLIT2 expression increased with malignant progression and correlated with poor survival and immunosuppression. Knockdown of SLIT2 in mouse glioma cells and patient-derived GBM xenografts reduced tumor growth and rendered tumors sensitive to immunotherapy. Tumor cell SLIT2 knockdown inhibited macrophage invasion and promoted a cytotoxic gene expression profile, which improved tumor vessel function and enhanced efficacy of chemotherapy and immunotherapy. Mechanistically, SLIT2 promoted microglia/macrophage chemotaxis and tumor-supportive polarization via ROBO1- and ROBO2-mediated PI3K-[gamma] activation. Macrophage Robo1 and Robo2 deletion and systemic SLIT2 trap delivery mimicked SLIT2 knockdown effects on tumor growth and the tumor microenvironment (TME), revealing SLIT2 signaling through macrophage ROBOs as a potentially novel regulator of the GBM microenvironment and immunotherapeutic target for brain tumors., Introduction Malignant gliomas are the most common primary brain tumors (1, 2). Among those, glioblastoma (GBM; WHO grade IV glioma) is the most frequent and aggressive tumor, accounting for more [...]

Published
2021
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5. Effect of surgical experience and spine subspecialty on the reliability of the AO Spine Upper Cervical Injury Classification System

Author

Lambrechts, Mark J., primary, Schroeder, Gregory D., additional, Karamian, Brian A., additional, Canseco, Jose A., additional, Oner, F. Cumhur, additional, Benneker, Lorin M., additional, Bransford, Richard J., additional, Kandziora, Frank, additional, Rajasekaran, Shanmuganathan, additional, El-Sharkawi, Mohammad, additional, Kanna, Rishi, additional, Joaquim, Andrei Fernandes, additional, Schnake, Klaus, additional, Kepler, Christopher K., additional, Vaccaro, Alexander R., additional, _, _, additional, Asif, Dewan, additional, Borkar, Sachin, additional, Bakar, Joseph, additional, Zagorac, Slavisa, additional, Wimalachandra, Welege, additional, Garashchuk, Oleksandr, additional, Verdu-Lopez, Francisco, additional, Lofrese, Giorgio, additional, Bhatt, Pragnesh, additional, Obadaseraye, Oke, additional, Partenheimer, Axel, additional, Riehle, Marion, additional, Popescu, Eugen Cesar, additional, Konrads, Christian, additional, Senan, Nur Aida Faruk, additional, Toluse, Adetunji, additional, Neves, Nuno, additional, Sunami, Takahiro, additional, Kuipers, Bart, additional, Subbiah, Jayakumar, additional, Dyab, Anas, additional, Loughenbury, Peter, additional, Cawley, Derek, additional, Schmidt, René, additional, Kumar, Loya, additional, Karim, Farhan, additional, Silk, Zacharia, additional, Parolin, Michele, additional, Robijn, Hisco, additional, Kalbani, Al, additional, Rasschaert, Ricky, additional, Müller, Christian, additional, Nieuwenhuijse, Marc, additional, Ayhan, Selim, additional, Menachem, Shay, additional, Dhatt, Sarvdeep, additional, Khan, Nasser, additional, Haribabu, Subramaniam, additional, Kimani, Moses, additional, Alarcon, Olger, additional, Alor, Nnaemeka, additional, Iyer, Dinesh, additional, Ziga, Michal, additional, Gousias, Konstantinos, additional, Murray, Gisela, additional, Triffaux, Michel, additional, Hartmann, Sebastian, additional, Yuh, Sung-Joo, additional, Lang, Siegmund, additional, Linn, Kyaw, additional, Dhillon, Charanjit Singh, additional, Hamouda, Waeel, additional, Carnesecchi, Stefano, additional, Kumar, Vishal, additional, Cari, Lady Lozano, additional, Shah, Gyanendra, additional, Takeo, Furuya, additional, Sartor, Federico, additional, Gonzalez, Fernando, additional, Dabasia, Hitesh, additional, Liawrungrueang, Wongthawat, additional, Liu, Lincoln, additional, El Moudni, Younes, additional, Yurak, Ratko, additional, Aceituno, Héctor, additional, Karthigeyan, Madhivanan, additional, Demetriades, Andreas, additional, Muthu, Sathish, additional, Scholz, Matti, additional, Alsammak, Wael, additional, Chandrachari, Komal, additional, Shan, Khoh Phaik, additional, Trungu, Sokol, additional, Dejaegher, Joost, additional, Marroquin, Omar, additional, Alexandru, Moisa Horatiu, additional, Diez-Ulloa, Máximo-Alberto, additional, Pereira, Paulo, additional, Bernucci, Claudio, additional, Hohaus, Christian, additional, Georgiopoulos, Miltiadis, additional, Heuer, Annika, additional, Atan, Ahmed Arieff, additional, Murerwa, Mark, additional, Lindtner, Richard, additional, Tripathi, Manjul, additional, Kim, Huynh Hieu, additional, Hassan, Ahmed, additional, Foster, Norah, additional, O’Halloran, Amanda, additional, Kabir, Koroush, additional, Ganau, Mario, additional, Cruz, Daniel, additional, Henine, Amin, additional, Milano, Jeronimo, additional, Mbarak, Abeid, additional, Sousa, Arnaldo, additional, Munjal, Satyashiva, additional, Alkharsawi, Mahmoud, additional, Mirza, Muhammad, additional, Tsitsopoulos, Parmenion, additional, Tsuang, Fon-Yih, additional, Risenbeck, Oliver, additional, Viswanadha, Arun-Kumar, additional, Samy, Samer, additional, Orosco, David, additional, Zambito-Brondo, Gerardo, additional, Chaudhry, Nauman, additional, Marquez, Luis, additional, Lepard, Jacob, additional, Muñoz, Juan, additional, Corluka, Stipe, additional, Reuben, Soh, additional, Kaen, Ariel, additional, Ampar, Nishanth, additional, Bigdon, Sebastien, additional, Caba, Damián, additional, De Miranda, Francisco, additional, Lay, Loren, additional, Marintschev, Ivan, additional, Imran, Mohammed, additional, Mohindra, Sandeep, additional, Reddycherla, Naga Raju, additional, Bazán, Pedro, additional, Alhammoud, Abduljabbar, additional, Feeley, Iain, additional, Margetis, Konstantinos, additional, Durst, Alexander, additional, Jani, Ashok Kumar, additional, Vieira, Rian Souza, additional, Santos, Felipe, additional, Karlin, Joshua, additional, Montemurro, Nicola, additional, Mlyavykh, Sergey, additional, Sonkwe, Brian, additional, Perovic, Darko, additional, Lourido, Juan, additional, Ramieri, Alessandro, additional, Laos, Eduardo, additional, Hadesberg, Uri, additional, Iencean, Andrei-Stefan, additional, Neves, Pedro, additional, Bertolini, Eduardo, additional, Kumar, Naresh, additional, Bancel, Philippe, additional, Sharma, Bishnu, additional, Koerner, John, additional, Neto, Eloy Rusafa, additional, Ostadrahimi, Nima, additional, Morillo, Olga, additional, Rakesh, Kumar, additional, Morakis, Andreas, additional, Godinho, Amauri, additional, Keerthivasan, P., additional, Menger, Richard, additional, Carius, Louis, additional, Lakhey, Rajesh Bahadur, additional, Shiban, Ehab, additional, Borse, Vishal, additional, Boudreau, Elizabeth, additional, Lacerda, Gabriel, additional, Konstantinos, Paterakis, additional, Saeed, Mubder Mohammed, additional, Hasheela, Toivo, additional, Pereira, Susana Núñez, additional, Reidler, Jay, additional, Rahamimov, Nimrod, additional, Zimny, Mikolaj, additional, Tokala, Devi Prakash, additional, Elgafy, Hossein, additional, Badani, Ketan, additional, Ng, Bing Wui, additional, Juarez, Cesar Sosa, additional, Repantis, Thomas, additional, Fernández-Bances, Ignacio, additional, Kleimeyer, John, additional, Lauper, Nicolas, additional, Romero-Muñoz, Luis María, additional, Yusuf, Ayodeji, additional, Klez, Zdenek, additional, Afolayan, John, additional, Rutges, Joost, additional, Grundshtein, Alon, additional, Zaluski, Rafal, additional, Stavridis, Stavros I., additional, Aoyama, Takeshi, additional, Vachata, Petr, additional, Urbanski, Wiktor, additional, Tejeda, Martin, additional, Muñiz, Luis, additional, Karanja, Susan, additional, Martín-Benlloch, Antonio, additional, Torres, Heiller, additional, Pan, Chee-Huan, additional, Duchén, Luis, additional, Fujioka, Yuki, additional, Enercan, Meric, additional, Pluderi, Mauro, additional, Majer, Catalin, additional, and Kamath, Vijay, additional

Published
2023
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6. A Systematic Review of Current Terminology for Conditions Preceding Degenerative Cervical Myelopathy: Evidence to Inform an AO Spine Expert Opinion Statement

Author

Agrawal, Vinisha, primary, Yasin, Froher, additional, Yurac, Ratko, additional, Kumar, Vishal, additional, Murphy, Rory, additional, Tessitore, Enrico, additional, Molliqaj, Granit, additional, Dejaegher, Joost, additional, Zamorano, Juan Jose, additional, Wynne-Jones, Guy, additional, Kotter, Mark, additional, Davies, Benjamin, additional, Nouri, Aria, additional, and Mowforth, Oliver, additional

Published
2023
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7. Applying a knowledge translation framework for triaging low back pain and radicular pain at an emergency department: an iterative process within an uncontrolled before-and-after design

Author

Peters, Sanne, primary, Jacobs, Karel, additional, Van Wambeke, Peter, additional, Rummens, Sofie, additional, Schelfaut, Sebastiaan, additional, Moke, Lieven, additional, Dejaegher, Joost, additional, Spriet, Ann, additional, Van den Broeck, Anne-lies, additional, Vliers, Johan, additional, and Depreitere, Bart, additional

Published
2022
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11. SLIT2-ROBO signaling in tumor-associated microglia/macrophages drives glioblastoma immunosuppression and vascular dysmorphia

Author

Geraldo, Luiz Henrique, primary, Xu, Yunling, additional, Jacob, Laurent, additional, Fragner, Laurence Pibouin, additional, Rao, Rohit, additional, Maissa, Nawal, additional, Verreault, Maïté, additional, Lemaire, Nolwenn, additional, Knosp, Camille, additional, Lesaffre, Corinne, additional, Daubon, Thomas, additional, Dejaegher, Joost, additional, Solie, Lien, additional, Rudewicz, Justine, additional, Viel, Thomas, additional, Tavitian, Bertrand, additional, De Vleeschouwer, Steven, additional, Sanson, Marc, additional, Bikfalvi, Andreas, additional, Idbaih, Ahmed, additional, Lu, Q. Richard, additional, Souza Lima, Flavia Regina, additional, Thomas, Jean-Leon, additional, Eichmann, Anne, additional, and Mathivet, Thomas, additional

Published
2021
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12. DNA methylation based glioblastoma subclassification is related to tumoral T-cell infiltration and patient survival

Author

Dejaegher, Joost, primary, Solie, Lien, additional, Hunin, Zoé, additional, Sciot, Raf, additional, Capper, David, additional, Siewert, Christin, additional, Van Cauter, Sofie, additional, Wilms, Guido, additional, van Loon, Johan, additional, Ectors, Nadine, additional, Fieuws, Steffen, additional, Pfister, Stefan M, additional, Van Gool, Stefaan W, additional, and De Vleeschouwer, Steven, additional

Published
2020
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16. Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive factors for treatment response

Author

De Vleeschouwer, Steven, Dejaegher,Joost, and Van Gool,Stefaan

Subjects
ImmunoTargets and Therapy
Abstract

Joost Dejaegher,1 Stefaan Van Gool,2 Steven De Vleeschouwer1 1Department of Neurosciences, 2Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium Abstract: Glioblastoma multiforme (GBM) is the most common and most aggressive type of primary brain cancer. Since median overall survival with multimodal standard therapy is only 15 months, there is a clear need for additional effective and long-lasting treatments. Dendritic cell (DC) vaccination is an experimental immunotherapy being tested in several Phase I and Phase II clinical trials. In these trials, safety and feasibility have been proven, and promising clinical results have been reported. On the other hand, it is becoming clear that not every GBM patient will benefit from this highly personalized treatment. Defining the subgroup of patients likely to respond to DC vaccination will position this option correctly amongst other new GBM treatment modalities, and pave the way to incorporation in standard therapy. This review provides an overview of GBM treatment options and focuses on the currently known prognostic and predictive factors for response to DC vaccination. In this way, it will provide the clinician with the theoretical background to refer patients who might benefit from this treatment. Keywords: immunotherapy, personalized medicine, brain tumor, stratification

Published
2014

18. Tension Pneumocephalus With Acute Cerebellar Symptoms Due to an Intradiploic Epidermoid Cyst Eroding the Mastoid Bone.

Author

Schepens J, Van Havenbergh F, Dejaegher J, Demaerel P, Sciot R, and De Vleeschouwer S

Abstract

This case report presents a unique presentation of an intradiploic epidermoid cyst (IDEC) in a 55-year-old female. She presented with acute cerebellar symptoms triggered by a Valsalva maneuver. IDECs are a rare type of intracranial epidermoid cysts. They are benign and have a slow growth pattern that translates into progressively developing symptoms instead of acute symptoms. Symptoms include local deformities, focal neurologic deficits, and pain. This patient developed acute cerebellar symptoms due to erosion of the mastoid bone that created a pathway between the eustachian tube and the intracranial space via the mastoid air cells. Consequently, tension pneumocephalus emerged via a ball-valve effect that caused a significant mass effect in the posterior fossa. Surgical resection of the IDEC and closing of the mastoid air cells resulted in symptom relief by restoring the integrity of the intracranial-extracranial barrier. This case highlights that a higher level of vigilance is warranted for an IDEC in the proximity of aerated bone structures, such as the mastoid air cells and the paranasal sinuses, and that a more proactive approach is advocated., Competing Interests: The authors have declared that no competing interests exist., (Copyright © 2024, Schepens et al.)

Published
2024
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19. Dendritic cell vaccination for glioblastoma multiforme: review with focus on predictive factors for treatment response.

Author

Dejaegher J, Van Gool S, and De Vleeschouwer S

Abstract

Glioblastoma multiforme (GBM) is the most common and most aggressive type of primary brain cancer. Since median overall survival with multimodal standard therapy is only 15 months, there is a clear need for additional effective and long-lasting treatments. Dendritic cell (DC) vaccination is an experimental immunotherapy being tested in several Phase I and Phase II clinical trials. In these trials, safety and feasibility have been proven, and promising clinical results have been reported. On the other hand, it is becoming clear that not every GBM patient will benefit from this highly personalized treatment. Defining the subgroup of patients likely to respond to DC vaccination will position this option correctly amongst other new GBM treatment modalities, and pave the way to incorporation in standard therapy. This review provides an overview of GBM treatment options and focuses on the currently known prognostic and predictive factors for response to DC vaccination. In this way, it will provide the clinician with the theoretical background to refer patients who might benefit from this treatment.

Published
2014
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