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1. Transmission and dynamics of mother-infant gut viruses during pregnancy and early life

Author

Garmaeva, Sanzhima, Sinha, Trishla, Gulyaeva, Anastasia, Kuzub, Nataliia, Spreckels, Johanne E., Andreu-Sánchez, Sergio, Gacesa, Ranko, Vich Vila, Arnau, Brushett, Siobhan, Kruk, Marloes, Dekens, Jackie, Sikkema, Jan, Kuipers, Folkert, Shkoporov, Andrey N., Hill, Colin, Scherjon, Sicco, Wijmenga, Cisca, Fu, Jingyuan, Kurilshikov, Alexander, and Zhernakova, Alexandra

Published
2024
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5. Mother-Infant Gut Viruses and their Bacterial Hosts: Transmission Patterns and Dynamics during Pregnancy and Early Life

Author

Garmaeva, Sanzhima, primary, Sinha, Trishla, additional, Gulyaeva, Anastasia, additional, Kuzub, Nataliia, additional, Spreckels, Johanne E, additional, Andreu-Sanchez, Sergio, additional, Gacesa, Ranko, additional, Vich Vila, Arnau, additional, Brushett, Siobhan, additional, Kruk, Marloes, additional, Dekens, Jackie, additional, Sikkema, Jan, additional, Kuipers, Folkert, additional, Shkoporov, Andrey, additional, Hill, Colin, additional, Scherjon, Sicco, additional, Wijmenga, Cisca, additional, Fu, Jingyuan, additional, Kurilshikov, Alexander, additional, and Zhernakova, Alexandra, additional

Published
2023
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6. Workplace impact on employees: A Lifelines Corona Research Initiative on the return to work

Author

Mobach, Mark P., Boezen, H. M, Mierau, Jochen O., Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geer Truida H., Rosmalen, Judith G.M., Wijmenga, Cisca, Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Research programme EEF, Faculteit Medische Wetenschappen/UMCG, Stem Cell Aging Leukemia and Lymphoma (SALL), Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI), ​Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Damage and Repair in Cancer Development and Cancer Treatment (DARE), and Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE)

Abstract

A large proportion of the global workforce migrated home during the COVID-19 pandemic and subsequent lockdowns. It remains unclear what the exact differences between home workers and non-home workers were, especially during the pandemic when a return to work was imminent. How were building, workplace, and related facilities associated with workers’ perceptions and health? What are the lessons to be learned? Lifelines Corona Research Initiative was used to compare employees’ workplaces and related concerns, facilities, work quality, and health in a complete case analysis (N = 12,776) when return to work was imminent. Mann-Whitney U, logistic regression, and Wilcoxon matched-pairs were used for analyses. Notwithstanding small differences, the results show that home workers had less favourable scores for concerns about and facilities of on-site buildings and workplaces upon return to work, but better scores for work quality and health than non-home workers. However, additional analyses also suggest that building, workplace, and related facilities may have had the capacity to positively influence employees’ affective responses and work quality, but not always their health.

Published
2023

7. Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines.

Author

Goërtz, Yvonne M. J., Spruit, Martijn A., Van Herck, Maarten, Dukers-Muijrers, Nicole, Lifelines Corona Research Initiative, Boezen, H. Marike, Mierau, Jochen O., Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P. S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X. L., Wiersma, Henry H., Warmerdam, Robert, and Jankipersadsing, Soesma A.

Subjects
DIAGNOSTIC use of polymerase chain reaction, SARS-CoV-2, COVID-19 testing, POLYMERASE chain reaction, SYMPTOMS
Abstract

This study evaluates to what extent symptoms are present before, during, and after a positive SARS-CoV-2 polymerase chain reaction (PCR) test, and to evaluate how the symptom burden and quality of Life (QoL) compares to those with a negative PCR test. Participants from the Dutch Lifelines COVID-19 Cohort Study filled-out as of March 2020 weekly, later bi-weekly and monthly, questions about demographics, COVID-19 diagnosis and severity, QoL, and symptoms. The study population included those with one positive or negative PCR test who filled out two questionnaires before and after the test, resulting in 996 SARS-CoV-2 PCR positive and 3978 negative participants. Nearly all symptoms were more often reported after a positive test versus the period before the test (p < 0.05), except fever. A higher symptom prevalence after versus before a test was also found for nearly all symptoms in negatives (p < 0.05). Before the test, symptoms were already partly present and reporting of nearly all symptoms before did not differ between positives and negatives (p > 0.05). QoL decreased around the test for positives and negatives, with a larger deterioration for positives. Not all symptoms after a positive SARS-CoV-2 PCR test might be attributable to the infection and symptoms were also common in negatives. [ABSTRACT FROM AUTHOR]

Published
2023
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8. Impact of the COVID-19 pandemic on adults with moderate-to-severe atopic dermatitis in the Dutch general population

Author

Zhang, Junfen, Loman, Laura, Kamphuis, Esmé, Schuttelaar, Marie L A, Boezen, H. M., Mierau, Jochen, Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja M., Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X L, Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, Public Health Research (PHR), Life Course Epidemiology (LCE), Groningen Research Institute for Asthma and COPD (GRIAC), Value, Affordability and Sustainability (VALUE), Research programme EEF, Stem Cell Aging Leukemia and Lymphoma (SALL), and Groningen Institute for Gastro Intestinal Genetics and Immunology (3GI)

Subjects
atopic dermatitis, RL1-803, atopic eczema, COVID-19, disease severity, epidemiology, Dermatology, general population, Article
Published
2022

9. Frailty and risk of hospitalization from COVID-19 infection among older adults : evidence from the Dutch Lifelines COVID-19 Cohort study

Author

Zhu, Yinjie, Sealy, Martine J., Jager-Wittenaar, Harriët, Mierau, Jochen O., Bakker, Stephan J.L., Navis, Gerjan J., Boezen, H.M., Franke, H.L., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geertruida H., Rosmalen, Judith G.M., Wijmenga, Cisca, Zhu, Yinjie, Sealy, Martine J., Jager-Wittenaar, Harriët, Mierau, Jochen O., Bakker, Stephan J.L., Navis, Gerjan J., Boezen, H.M., Franke, H.L., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., van Blokland, Irene, de Bock, Geertruida H., Rosmalen, Judith G.M., and Wijmenga, Cisca

Abstract

Background: Frailty is associated with COVID-19 severity in clinical settings. No general population-based studies on the association between actual frailty status and COVID-19 hospitalization are available. Aims: To investigate the association between frailty and the risk of COVID-19 hospitalization once infected. Methods: 440 older adults who participated in the Lifelines COVID-19 Cohort study in the Northern Netherlands and reported positive COVID-19 testing results (54.2% women, age 70 ± 4 years in 2021) were included in the analyses. COVID-19 hospitalization status was self-reported. The Groningen Frailty Indicator (GFI) was derived from 15 self-reported questionnaire items related to daily activities, health problems, and psychosocial functioning, with a score ≥ 4 indicating frailty. Both frailty and COVID-19 hospitalization were assessed in the same period. Poisson regression models with robust standard errors were used to analyze the associations between frailty and COVID-19 hospitalization. Results: Of 440 older adults included, 42 were hospitalized because of COVID-19 infection. After adjusting for sociodemographic and lifestyle factors, a higher risk of COVID-19 hospitalization was observed for frail individuals (risk ratio (RR) [95% CI] 1.97 [1.06–3.67]) compared to those classified as non-frail. Discussion: Frailty was positively associated with COVID-19 hospitalization once infected, independent of sociodemographic and lifestyle factors. Future research on frailty and COVID-19 should consider biomarkers of aging and frailty to understand the pathophysiological mechanisms and manifestations between frailty and COVID-19 outcomes. Conclusions: Frailty was positively associated with the risk of hospitalization among older adults that were infected with COVID-19. Public health strategies for frailty prevention in older adults need to be advocated, as it is helpful to reduce the burden of the healthcare system, particularly during a pandemic like COVID-19.

Published
2022

10. Circulating miRNAs as Potential Biomarkers for Celiac Disease Development

Author

Tan, Ineke L., primary, Coutinho de Almeida, Rodrigo, additional, Modderman, Rutger, additional, Stachurska, Anna, additional, Dekens, Jackie, additional, Barisani, Donatella, additional, Meijer, Caroline R., additional, Roca, María, additional, Martinez-Ojinaga, Eva, additional, Shamir, Raanan, additional, Auricchio, Renata, additional, Korponay-Szabó, Ilma R., additional, Castillejo, Gemma, additional, Szajewska, Hania, additional, Koletzko, Sibylle, additional, Zhernakova, Alexandra, additional, Kumar, Vinod, additional, Li, Yang, additional, Visschedijk, Marijn C., additional, Weersma, Rinse K., additional, Troncone, Riccardo, additional, Mearin, M. Luisa, additional, Wijmenga, Cisca, additional, Jonkers, Iris, additional, and Withoff, Sebo, additional

Published
2021
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11. Transmission of gut bacteria and viruses from mothers to infants

Author

Garmaeva, Sanzhima, primary, Sinha, Trishla, additional, Gulyaeva, Anastasia, additional, Gacesa, Ranko, additional, Andreu-Sanchez, Sergio, additional, Vila, Arnau Vich, additional, Chen, Lianmin, additional, Spreckels, Johanne, additional, Brushett, Siobhan, additional, Kruk, Marloes, additional, Dekens, Jackie, additional, Sikkema, Jan, additional, Kuipers, Folkert, additional, Shkoporov, Andrey, additional, Hill, Colin, additional, Scherjon, Sicco, additional, Kurilshikov, Alexander, additional, Wijmenga, Cisca, additional, Fu, Jingyuan, additional, and Zhernakova, Alexandra, additional

Published
2021
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12. Gender differences in the mental health impact of the COVID-19 lockdown: Longitudinal evidence from the Netherlands

Author

Vloo, A., primary, Alessie, R.J.M., additional, Mierau, J.O., additional, Boezen, Marike H., additional, Mierau, Jochen O., additional, Franke, Lude, additional, Dekens, Jackie, additional, Deelen, Patrick, additional, Lanting, Pauline, additional, Vonk, Judith M., additional, Nolte, Ilja, additional, Ori, Anil P.S., additional, Claringbould, Annique, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X.L., additional, Wiersma, Henry H., additional, Warmerdam, Robert, additional, and Jankipersadsing, Soesma A., additional

Published
2021
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13. Circulating miRNAs as Potential Biomarkers for Celiac Disease Development

Author

Tan, Ineke L., Coutinho de Almeida, Rodrigo, Modderman, Rutger, Stachurska, Anna, Dekens, Jackie, Barisani, Donatella, Kumar, V., Li, Y., Jonkers, Iris, Withoff, Sebo, Tan, Ineke L., Coutinho de Almeida, Rodrigo, Modderman, Rutger, Stachurska, Anna, Dekens, Jackie, Barisani, Donatella, Kumar, V., Li, Y., Jonkers, Iris, and Withoff, Sebo

Abstract

Contains fulltext : 242773.pdf (Publisher’s version ) (Open Access)

Published
2021

14. Lifelines COVID-19 cohort: investigating COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

Author

Mc Intyre, Katherine, primary, Lanting, Pauline, additional, Deelen, Patrick, additional, Wiersma, Henry H, additional, Vonk, Judith M, additional, Ori, Anil P S, additional, Jankipersadsing, Soesma A, additional, Warmerdam, Robert, additional, van Blokland, Irene, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X L, additional, Herkert, Johanna C, additional, Claringbould, Annique, additional, Bakker, Olivier, additional, Lopera Maya, Esteban A, additional, Bültmann, Ute, additional, Zhernakova, Alexandra, additional, Reijneveld, Sijmen A, additional, Zijlstra, Elianne, additional, Swertz, Morris A, additional, Brouwer, Sandra, additional, van Ooijen, Raun, additional, Angelini, Viola, additional, Dekker, Louise H, additional, Sijtsma, Anna, additional, Scherjon, Sicco A, additional, Wijmenga, Cisca, additional, Dekens, Jackie A M, additional, Mierau, Jochen, additional, Boezen, H Marike, additional, and Franke, Lude, additional

Published
2021
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15. The Dutch Microbiome Project defines factors that shape the healthy gut microbiome

Author

Weersma, Rinse, primary, Gacesa, Ranko, additional, Kurilshikov, Alexander, additional, Vila, Arnau Vich, additional, Sinha, Trishla, additional, Klaassen, Marjolein, additional, Bolte, Laura, additional, Andreu-Sanchez, Sergio, additional, Chen, Lianmin, additional, Collij, Valerie, additional, Hu, Shixian, additional, Dekens, Jackie, additional, Lenters, Virissa, additional, Björk, Johannes, additional, Swarte, J. Casper, additional, Swertz, Morris, additional, Jansen, B. H., additional, Gelderloos-Arends, Jody, additional, Hofker, Marten, additional, Vermeuelen, Roel, additional, Sanna, Serena, additional, Harmsen, Hermie, additional, Wijmenga, Cisca, additional, Fu, Jingyuan, additional, and Zhernakova, Alexandra, additional

Published
2020
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16. The Lifelines COVID-19 Cohort: a questionnaire-based study to investigate COVID-19 infection and its health and societal impacts in a Dutch population-based cohort

Author

Intyre, Kate Mc, primary, Lanting, Pauline, additional, Deelen, Patrick, additional, Wiersma, Henry, additional, Vonk, Judith M., additional, Ori, Anil P.S., additional, Jankipersadsing, Soesma A., additional, Warmerdam, Robert, additional, van Blokland, Irene, additional, Boulogne, Floranne, additional, Dijkema, Marjolein X.L., additional, Herkert, Johanna C., additional, Claringbould, Annique, additional, Bakker, Olivier, additional, Lopera Maya, Esteban A., additional, Bültmann, Ute, additional, Zhernakova, Alexandra, additional, Reijneveld, Sijmen A., additional, Zijlstra, Elianne, additional, Swertz, Morris, additional, Brouwer, Sandra, additional, van Ooijen, R., additional, Angelini, Viola, additional, Dekker, Louise, additional, Sijtsma, Anna, additional, Scherjon, Sicco A., additional, Dekens, Jackie, additional, Mierau, Jochen O., additional, Boezen, H. Marike, additional, and Franke, Lude, additional

Published
2020
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17. Habitual dietary intake of IBD patients differs from population controls: a case–control study

Author

Peters, Vera, primary, Tigchelaar-Feenstra, Ettje F., additional, Imhann, Floris, additional, Dekens, Jackie A. M., additional, Swertz, Morris A., additional, Franke, Lude H., additional, Wijmenga, Cisca, additional, Weersma, Rinse K., additional, Alizadeh, Behrooz Z., additional, Dijkstra, Gerard, additional, and Campmans-Kuijpers, Marjo J. E., additional

Published
2020
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18. Sex and Gender-Related Differences in COVID-19 Diagnoses and SARS-CoV-2 Testing Practices During the First Wave of the Pandemic: The Dutch Lifelines COVID-19 Cohort Study.

Author

Ballering, Aranka Viviënne, Oertelt-Prigione, Sabine, olde Hartman, Tim C., Rosmalen, Judith G.M., Boezen, Marike, Mierau, Jochen O., Franke, Lude H., Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P.S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X.L., Wiersma, Henry H., Warmerdam, Robert, and Jankipersadsing, Soesma A.

Subjects
STATISTICS, EVALUATION of medical care, REVERSE transcriptase polymerase chain reaction, COVID-19, CONFIDENCE intervals, MULTIPLE regression analysis, SEX distribution, EMPLOYMENT, DESCRIPTIVE statistics, COVID-19 testing, POLYMERASE chain reaction, SMOKING, ODDS ratio, COVID-19 pandemic, LONGITUDINAL method, COMORBIDITY
Abstract

Background: Although sex differences are described in Coronavirus Disease 2019 (COVID-19) diagnoses and testing, many studies neglect possible gender-related influences. Additionally, research is often performed in clinical populations, while most COVID-19 patients are not hospitalized. Therefore, we investigated associations between sex and gender-related variables, and COVID-19 diagnoses and testing practices in a large general population cohort during the first wave of the pandemic when testing capacity was limited. Methods: We used data from the Lifelines COVID-19 Cohort (N = 74,722; 60.8% female). We applied bivariate and multiple logistic regression analyses. The outcomes were a COVID-19 diagnosis (confirmed by SARS-CoV-2 PCR testing or physician's clinical diagnosis) and PCR testing. Independent variables included among others participants' sex, age, somatic comorbidities, occupation, and smoking status. Sex-by-comorbidity and sex-by-occupation interaction terms were included to investigate sex differences in associations between the presence of comorbidities or an occupation with COVID-19 diagnoses or testing practices. Results: In bivariate analyses female sex was significantly associated with COVID-19 diagnoses and testing, but significance did not persist in multiple logistic regression analyses. However, a gender-related variable, being a health care worker, was significantly associated with COVID-19 diagnoses (OR = 1.68; 95%CI = 1.30–2.17) and testing (OR = 12.5; 95%CI = 8.55–18.3). Female health care workers were less often diagnosed and tested than male health care workers (ORinteraction = 0.54; 95%CI = 0.32–0.92, ORinteraction = 0.53; 95%CI = 0.29–0.97, respectively). Conclusions: We found no sex differences in COVID-19 diagnoses and testing in the general population. Among health care workers, a male preponderance in COVID-19 diagnoses and testing was observed. This could be explained by more pronounced COVID-19 symptoms in males or by gender inequities. [ABSTRACT FROM AUTHOR]

Published
2021
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19. Author Correction: Symptoms and quality of life before, during, and after a SARS‑CoV‑2 PCR positive or negative test: data from Lifelines.

Author

Goërtz, Yvonne M. J., Spruit, Martijn A., Van Herck, Maarten, Dukers-Muijrers, Nicole, Boezen, H. Marike, Mierau, Jochen O., Franke, H. Lude, Dekens, Jackie, Deelen, Patrick, Lanting, Pauline, Vonk, Judith M., Nolte, Ilja, Ori, Anil P. S., Claringbould, Annique, Boulogne, Floranne, Dijkema, Marjolein X. L., Wiersma, Henry H., Warmerdam, Robert, Jankipersadsing, Soesma A., and van Blokland, Irene

Subjects
SARS-CoV-2, QUALITY of life, SYMPTOMS, CONSORTIA
Abstract

This document is a correction notice for an article titled "Symptoms and quality of life before, during, and after a SARS-CoV-2 PCR positive or negative test: data from Lifelines" published in Scientific Reports. The correction states that H. Marike Boezen, one of the authors, is deceased. Additionally, there was an error in the Consortium list, where Judith G. M. Rosmalen was incorrectly listed as an author. The correction has been made to the original article. The authors of the article are Yvonne M. J. Goërtz, Martijn A. Spruit, Maarten Van Herck, Nicole Dukers-Muijrers, H. Marike Boezen, Jochen O. Mierau, H. Lude Franke, Jackie Dekens, Patrick Deelen, Pauline Lanting, Judith M. Vonk, Ilja Nolte, Anil P. S. Ori, Annique Claringbould, Floranne Boulogne, Marjolein X. L. Dijkema, Henry H. Wiersma, Robert Warmerdam, Soesma A. Jankipersadsing, Irene van Blokland, Geertruida H. de Bock, Cisca Wijmenga, Carla J. H. van der Kallen, Chris Burtin, and Daisy J. A. Janssen. [Extracted from the article]

Published
2024
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21. Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Author

Vich Vila, Arnau, primary, Imhann, Floris, additional, Collij, Valerie, additional, Jankipersadsing, Soesma A., additional, Gurry, Thomas, additional, Mujagic, Zlatan, additional, Kurilshikov, Alexander, additional, Bonder, Marc Jan, additional, Jiang, Xiaofang, additional, Tigchelaar, Ettje F., additional, Dekens, Jackie, additional, Peters, Vera, additional, Voskuil, Michiel D., additional, Visschedijk, Marijn C., additional, van Dullemen, Hendrik M., additional, Keszthelyi, Daniel, additional, Swertz, Morris A., additional, Franke, Lude, additional, Alberts, Rudi, additional, Festen, Eleonora A. M., additional, Dijkstra, Gerard, additional, Masclee, Ad A. M., additional, Hofker, Marten H., additional, Xavier, Ramnik J., additional, Alm, Eric J., additional, Fu, Jingyuan, additional, Wijmenga, Cisca, additional, Jonkers, Daisy M. A. E., additional, Zhernakova, Alexandra, additional, and Weersma, Rinse K., additional

Published
2018
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22. Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome

Author

Vila, Arnau Vich, Vila, Arnau Vich, Imhann, Floris, Collij, Valerie, Jankipersadsing, Soesma A., Gurry, Thomas, Mujagic, Zlatan, Kurilshikov, Alexander, Bonder, Marc Jan, Jiang, Xiaofang, Tigchelaar, Ettje F., Dekens, Jackie, Peters, Vera, Voskuil, Michiel D., Visschedijk, Marijn C., van Dullemen, Hendrik M., Keszthelyi, Daniel, Swertz, Morris A., Franke, Lude, Alberts, Rudi, Festen, Eleonora A. M., Dijkstra, Gerard, Masclee, Ad A. M., Hofker, Marten H., Xavier, Ramnik J., Alm, Eric J., Fu, Jingyuan, Section, Cisca Wijmenga, Section, Daisy M. A. E. Jonkers, Zhernakova, Alexandra, Weersma, Rinse K., Vila, Arnau Vich, Vila, Arnau Vich, Imhann, Floris, Collij, Valerie, Jankipersadsing, Soesma A., Gurry, Thomas, Mujagic, Zlatan, Kurilshikov, Alexander, Bonder, Marc Jan, Jiang, Xiaofang, Tigchelaar, Ettje F., Dekens, Jackie, Peters, Vera, Voskuil, Michiel D., Visschedijk, Marijn C., van Dullemen, Hendrik M., Keszthelyi, Daniel, Swertz, Morris A., Franke, Lude, Alberts, Rudi, Festen, Eleonora A. M., Dijkstra, Gerard, Masclee, Ad A. M., Hofker, Marten H., Xavier, Ramnik J., Alm, Eric J., Fu, Jingyuan, Section, Cisca Wijmenga, Section, Daisy M. A. E. Jonkers, Zhernakova, Alexandra, and Weersma, Rinse K.

Abstract

Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.

Published
2018

23. The Gut Microbiome Contributes to a Substantial Proportion of the Variation in Blood Lipids

Author

Fu, Jingyuan, primary, Bonder, Marc Jan, additional, Cenit, María Carmen, additional, Tigchelaar, Ettje F., additional, Maatman, Astrid, additional, Dekens, Jackie A.M., additional, Brandsma, Eelke, additional, Marczynska, Joanna, additional, Imhann, Floris, additional, Weersma, Rinse K., additional, Franke, Lude, additional, Poon, Tiffany W., additional, Xavier, Ramnik J., additional, Gevers, Dirk, additional, Hofker, Marten H., additional, Wijmenga, Cisca, additional, and Zhernakova, Alexandra, additional

Published
2015
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24. Cohort profile: LifeLines DEEP, a prospective, general population cohort study in the northern Netherlands: study design and baseline characteristics

Author

Tigchelaar, Ettje F, primary, Zhernakova, Alexandra, additional, Dekens, Jackie A M, additional, Hermes, Gerben, additional, Baranska, Agnieszka, additional, Mujagic, Zlatan, additional, Swertz, Morris A, additional, Muñoz, Angélica M, additional, Deelen, Patrick, additional, Cénit, Maria C, additional, Franke, Lude, additional, Scholtens, Salome, additional, Stolk, Ronald P, additional, Wijmenga, Cisca, additional, and Feskens, Edith J M, additional

Published
2015
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25. An introduction to LifeLines DEEP: study design and baseline characteristics

Author

Tigchelaar, Ettje F, primary, Zhernakova, Alexandra, additional, Dekens, Jackie A.M., additional, Hermes, Gerben, additional, Baranska, Agnieszka, additional, Mujagic, Zlatan, additional, Swertz, Morris A, additional, Muñoz, Angélica M, additional, Deelen, Patrick, additional, Cénit, Maria C, additional, Franke, Lude, additional, Scholtens, Salome, additional, Stolk, Ronald P, additional, Wijmenga, Cisca, additional, and Feskens, Edith J.M., additional

Published
2014
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