1. 100% Fruit juice intake and cardiovascular risk: a systematic review and meta-analysis of prospective and randomised controlled studies
- Author
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D'Elia, L., Dinu, M., Sofi, F., Volpe, M., Strazzullo, P., Bordoni, A., Cairella, G., Casiraghi, M. C., del Balzo, V., Erba, D., Garbagnati, F., Ghiselli, A., Pellegrini, N., Pinto, A., Rossi, L., Russo, G. L., Scazzina, F., Scognamiglio, U., Vaccaro, S., Verduci, E., D'Elia L., Dinu M., Sofi F., Volpe M., Strazzullo P., Bordoni A., Cairella G., Casiraghi M.C., del Balzo V., Erba D., Garbagnati F., Ghiselli A., Pellegrini N., Pinto A., Rossi L., Russo G.L., Scazzina F., Scognamiglio U., Vaccaro S., and Verduci E.
- Subjects
medicine.medical_specialty ,Diabetes risk ,Diastole ,Medicine (miscellaneous) ,Blood lipids ,Coronary Disease ,Cardiovascular risk factor ,Internal medicine ,Medicine ,Humans ,Blood pressure ,Cardiovascular disease ,Cardiovascular risk factors ,Fruit juice ,Meta-analysis ,Blood Pressure ,Fruit and Vegetable Juices ,Heart Disease Risk Factors ,Cardiovascular Diseases ,Prospective cohort study ,Pulse wave velocity ,Nutrition and Dietetics ,business.industry ,Original Contribution ,blood pressure ,cardiovascular disease ,cardiovascular risk factors ,fruit juice ,meta-analysis ,Relative risk ,business - Abstract
Purpose The relationship between 100% fruit juice (100%FJ) consumption and cardiovascular risk is object of debate: indeed, recently published investigations provided new but discrepant evidence on this important question and International dietary guidelines are not in agreement on recommendations about fruit juice consumption. Therefore, we performed a meta-analysis of the prospective studies and the randomised controlled trials (RCTs) that explored the relationship between 100%FJ intake, cardiovascular risk profile and risk of cardiovascular events. Methods We performed a systematic search of publications up to August 2019. Summary relative risks and exploration of linearity of the association were estimated for prospective studies and summary mean differences (MDs) calculated for RCTs. Results A total of 21 prospective studies and 35 RCTs met the inclusion criteria. Dose–response analysis detected a significant inverse association between low-moderate 100%FJ consumption and risk of stroke (up to 200 ml/day) or total CV events (up to 170 ml/day) compared with no consumption, with a non-linear relationship (p for non-linearity Conclusions The results of these analyses indicate that 100%FJ consumption is not associated with higher CV risk. A non-linear inverse dose–response relationship occurs between 100%FJ consumption and CV disease, in particular for risk of stroke, probably mediated by the decrease in blood pressure. Trial registration PROSPERO registration number (CRD42019135577).
- Published
- 2020
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