689 results on '"Del Dotto, A."'
Search Results
2. Recovery of hydrogen plasma at the sub-nanosecond timescale in a plasma-wakefield accelerator
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Pompili, R., Anania, M. P., Biagioni, A., Carillo, M., Chiadroni, E., Cianchi, A., Costa, G., Crincoli, L., Del Dotto, A., Del Giorno, M., Demurtas, F., Ferrario, M., Galletti, M., Giribono, A., Jones, J. K., Lollo, V., Pacey, T., Parise, G., Di Pirro, G., Romeo, S., Silvi, G. J., Shpakov, V., Villa, F., and Zigler, A.
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- 2024
- Full Text
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3. Reconstruction of lateral coherence and 2D emittance in plasma betatron X-ray sources
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Curcio, Alessandro, Cianchi, Alessandro, Costa, Gemma, Del Dotto, Alessio, Demurtas, Francesco, Ferrario, Massimo, Frías, Maria Dolores Rodríguez, Galletti, Mario, Pérez-Hernández, José Antonio, and Gatti, Giancarlo
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- 2024
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- View/download PDF
4. ATHENA Detector Proposal -- A Totally Hermetic Electron Nucleus Apparatus proposed for IP6 at the Electron-Ion Collider
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ATHENA Collaboration, Adam, J., Adamczyk, L., Agrawal, N., Aidala, C., Akers, W., Alekseev, M., Allen, M. M., Ameli, F., Angerami, A., Antonioli, P., Apadula, N. J., Aprahamian, A., Armstrong, W., Arratia, M., Arrington, J. R., Asaturyan, A., Aschenauer, E. C., Augsten, K., Aune, S., Bailey, K., Baldanza, C., Bansal, M., Barbosa, F., Barion, L., Barish, K., Battaglieri, M., Bazilevsky, A., Behera, N. K., Berdnikov, V., Bernauer, J., Berriaud, C., Bhasin, A., Bhattacharya, D. S., Bielcik, J., Bielcikova, J., Bissolotti, C., Boeglin, W., Bondì, M., Borri, M., Bossu, F., Bouyjou, F., Brandenburg, J. D., Bressan, A., Brooks, M., Bueltmann, S. L., Byer, D., Caines, H., Sanchez, M. Calderon de la Barca, Calvelli, V., Camsonne, A., Cappelli, L., Capua, M., Castro, M., Cavazza, D., Cebra, D., Celentano, A., Chakaberia, I., Chan, B., Chang, W., Chartier, M., Chatterjee, C., Chen, D., Chen, J., Chen, K., Chen, Z., Chetri, H., Chiarusi, T., Chiosso, M., Chu, X., Chwastowski, J. J., Cicala, G., Cisbani, E., Cline, E., Cloet, I., Colella, D., Contalbrigo, M., Contin, G., Corliss, R., Corrales-Morales, Y., Crafts, J., Crawford, C., Cruz-Torres, R., D'Ago, D., D'Angelo, A., D'Hose, N., Dainton, J., Torre, S. Dalla, Dasgupta, S. S., Dash, S., Dashyan, N., Datta, J., Daugherity, M., De Vita, R., Deconinck, W., Defurne, M., Dehmelt, K., Del Dotto, A., Delcarro, F., Dellacasa, G., Demiroglu, Z. S., Deptuch, G. W., Desai, V., Deshpande, A., Devereaux, K., Dhillon, R., Di Salvo, R., Dilks, C., Dixit, D., Dobbs, S., Dong, X., Drachenberg, J., Drees, A., Dupre, R., Durham, M., Dzhygadlo, R., Fassi, L. El, Elia, D., Epple, E., Esha, R., Evdokimov, O., Eyser, O., Falchieri, D., Fan, W., Fantini, A., Fatemi, R., Fazio, S., Fegan, S., Filippi, A., Fox, H., Francisco, A., Freeze, A., Furletov, S., Furletova, Y., Gal, C., Gardner, S., Garg, P., Gaskell, D., Gates, K., Gericke, M. T. W., Geurts, F., Ghosh, C., Giacalone, M., Giacomini, F., Gilchrist, S., Glazier, D., Gnanvo, K., Gonella, L., Greiner, L. C., Guerrini, N., Guo, L., Gupta, A., Gupta, R., Guryn, W., He, X., Hemmick, T., Heppelmann, S., Higinbotham, D., Hoballah, M., Hoghmrtsyan, A., Hohlmann, M., Horn, T., Hornidge, D., Huang, H. Z., Hyde, C. E., Iapozzuto, P., Idzik, M., Jacak, B. V., Jadhav, M., Jain, S., Jena, C., Jentsch, A., Ji, Y., Ji, Z., Jia, J., Jones, P. G., Jones, R. W. I., Joosten, S., Joshi, S., Kabir, L., Kalicy, G., Karyan, G., Kashyap, V. K. S., Kawall, D., Ke, H., Kelsey, M., Kim, J., Kiryluk, J., Kiselev, A., Klein, S. R., Klest, H., Kochar, V., Korsch, W., Kosarzewski, L., Kotzinian, A., Krizek, F., Kumar, A., Kumar, K. S., Kumar, L., Kumar, R., Kumar, S., Kunnath, A., Kushawaha, N., Lacey, R., Lai, Y. S., Lalwani, K., Landgraf, J., Lanza, L., Lattuada, D., Lavinsky, M., Lee, J. H., Lee, S. H., Lemmon, R., Lestone, A., Lewis, N., Li, H., Li, S., Li, W., Li, X., Liang, X., Ligonzo, T., Lin, T., Liu, J., Liu, K., Liu, M., Livingston, K., Liyanage, N., Ljubicic, T., Long, O., Lukow, N., Ma, Y., Mammei, J., Mammoliti, F., Mamo, K., Mandjavidze, I., Maple, S., Marchand, D., Margotti, A., Markert, C., Markowitz, P., Marshall, T., Martin, A., Marukyan, H., Mastroserio, A., Mathew, S., Mayilyan, S., Mayri, C., McEneaney, M., Mei, Y., Meng, L., Meot, F., Metcalfe, J., Meziani, Z. -E., Mihir, P., Milton, R., Mirabella, A., Mirazita, M., Mkrtchyan, A., Mkrtchyan, H., Mohanty, B., Mondal, M., Morreale, A., Movsisyan, A., Muenstermann, D., Mukherjee, A., Camacho, C. Munoz, Murray, M. J., Mustafa, H., Myska, M., Nachman, B. P., Nagai, K., Naik, R., Naim, J. P., Nam, J., Nandi, B., Nappi, E., Nasim, Md., Neff, D., Neiret, D., Newman, P. R., Nguyen, M., Niccolai, S., Nie, M., Noferini, F., Norman, J., Noto, F., Nunes, A. S., O'Connor, T., Odyniec, G., Okorokov, V. A., Osipenko, M., Page, B., Palatchi, C., Palmer, D., Palni, P., Pandey, S., Panzieri, D., Park, S., Paschke, K., Pastore, C., Patra, R. N., Paul, A., Paul, S., Pecar, C., Peck, A., Pegg, I., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Piotrzkowski, K., Polakovic, T., Ploskon, M., Posik, M., Prasad, S., Preghenella, R., Priens, S., Prifti, E., Przybycien, M., Pujahari, P., Quintero, A., Radici, M., Radhakrishnan, S. K., Rahman, S., Rathi, S., Raue, B., Reed, R., Reimer, P., Reinhold, J., Renner, E., Rignanese, L., Ripani, M., Rizzo, A., Romanov, D., Roy, A., Rubini, N., Ruspa, M., Ruan, L., Sabatie, F., Sadhukhan, S., Sahoo, N., Sahu, P., Samuel, D., Sarkar, A., Sarsour, M., Schmidke, W., Schmookler, B., Schwarz, C., Schwiening, J., Scott, M., Sedgwick, I., Segreti, M., Sekula, S., Seto, R., Shah, N., Shahinyan, A., Sharma, D., Sharma, N., Sichtermann, E. P., Signori, A., Singh, A., Singh, B. K., Singh, S. N., Smirnov, N., Sokhan, D., Soltz, R., Sondheim, W., Spinali, S., Stacchi, F., Staszewski, R., Stepanov, P., Strazzi, S., Stroe, I. R., Sun, X., Surrow, B., Sweger, Z., Symons, T. J., Tadevosyan, V., Tang, A., Tassi, E., Teodorescu, L., Tessarotto, F., Thomas, D., Thomas, J. H., Toll, T., Tomasek, L., Torales-Acosta, F., Tribedy, P., Triloki, Tripathi, V., Trotta, R., Trzebiński, M., Trzeciak, B. A., Tsai, O., Tu, Z., Turrisi, R., Tuve, C., Ullrich, T., Urciuoli, G. M., Valentini, A., Vallarino, S., Vandenbroucke, M., Vanek, J., Vino, G., Volpe, G., Voskanyan, H., Vossen, A., Voutier, E., Wang, G., Wang, Y., Watts, D., Wickramaarachchi, N., Wilson, F., Wong, C. -P., Wu, X., Wu, Y., Xie, J., Xu, Q. -H., Xu, Z., Xu, Z. W., Yang, C., Yang, Q., Yang, Y., Ye, Z., Yi, L., Yin, Z., Yurov, M., Zachariou, N., Zhang, J., Zhang, Y., Zhang, Z., Zhao, Y., Zhao, Y. X., Zhao, Z., Zheng, L., and Zurek, M.
- Subjects
Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,Nuclear Experiment - Abstract
ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.
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- 2022
5. ATHENA detector proposal — a totally hermetic electron nucleus apparatus proposed for IP6 at the Electron-Ion Collider
- Author
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Adam, J, Adamczyk, L, Agrawal, N, Aidala, C, Akers, W, Alekseev, M, Allen, MM, Ameli, F, Angerami, A, Antonioli, P, Apadula, NJ, Aprahamian, A, Armstrong, W, Arratia, M, Arrington, JR, Asaturyan, A, Aschenauer, EC, Augsten, K, Aune, S, Bailey, K, Baldanza, C, Bansal, M, Barbosa, F, Barion, L, Barish, K, Battaglieri, M, Bazilevsky, A, Behera, NK, Berdnikov, V, Bernauer, J, Berriaud, C, Bhasin, A, Bhattacharya, DS, Bielcik, J, Bielcikova, J, Bissolotti, C, Boeglin, W, Bondì, M, Borri, M, Bossù, F, Bouyjou, F, Brandenburg, JD, Bressan, A, Brooks, M, Bültmann, SL, Byer, D, Caines, H, de la Barca Sanchez, M Calderon, Calvelli, V, Camsonne, A, Cappelli, L, Capua, M, Castro, M, Cavazza, D, Cebra, D, Celentano, A, Chakaberia, I, Chan, B, Chang, W, Chartier, M, Chatterjee, C, Chen, D, Chen, J, Chen, K, Chen, Z, Chetri, H, Chiarusi, T, Chiosso, M, Chu, X, Chwastowski, JJ, Cicala, G, Cisbani, E, Cline, E, Cloët, I, Colella, D, Contalbrigo, M, Contin, G, Corliss, R, Corrales-Morales, Y, Crafts, J, Crawford, C, Cruz-Torres, R, D'Ago, D, D'Angelo, A, D'Hose, N, Dainton, J, Torre, S Dalla, Dasgupta, SS, Dash, S, Dashyan, N, Datta, J, Daugherity, M, De Vita, R, Deconinck, W, Defurne, M, Dehmelt, K, Del Dotto, A, Delcarro, F, Dellacasa, G, and Demiroglu, ZS
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Nuclear and Plasma Physics ,Physical Sciences ,Large detector systems for particle and astroparticle physics ,Calorimeters ,Cherenkov detectors ,Particle tracking detectors ,Engineering ,Nuclear & Particles Physics ,Physical sciences - Abstract
ATHENA has been designed as a general purpose detector capable of delivering the full scientific scope of the Electron-Ion Collider. Careful technology choices provide fine tracking and momentum resolution, high performance electromagnetic and hadronic calorimetry, hadron identification over a wide kinematic range, and near-complete hermeticity. This article describes the detector design and its expected performance in the most relevant physics channels. It includes an evaluation of detector technology choices, the technical challenges to realizing the detector and the R&D required to meet those challenges.
- Published
- 2022
6. Science Requirements and Detector Concepts for the Electron-Ion Collider EIC Yellow Report
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Khalek, R Abdul, Accardi, A, Adam, J, Adamiak, D, Akers, W, Albaladejo, M, Al-bataineh, A, Alexeev, MG, Ameli, F, Antonioli, P, Armesto, N, Armstrong, WR, Arratia, M, Arrington, J, Asaturyan, A, Asai, M, Aschenauer, EC, Aune, S, Avagyan, H, Gayoso, C Ayerbe, Azmoun, B, Bacchetta, A, Baker, MD, Barbosa, F, Barion, L, Barish, KN, Barry, PC, Battaglieri, M, Bazilevsky, A, Behera, NK, Benmokhtar, F, Berdnikov, VV, Bernauer, JC, Bertone, V, Bhattacharya, S, Bissolotti, C, Boer, D, Boglione, M, Bondì, M, Boora, P, Borsa, I, Bossù, F, Bozzi, G, Brandenburg, JD, Brei, N, Bressan, A, Brooks, WK, Bufalino, S, Bukhari, MHS, Burkert, V, Buttimore, NH, Camsonne, A, Celentano, A, Celiberto, FG, Chang, W, Chatterjee, C, Chen, K, Chetry, T, Chiarusi, T, Chien, Y-T, Chiosso, M, Chu, X, Chudakov, E, Cicala, G, Cisbani, E, Cloet, IC, Cocuzza, C, Cole, PL, Colella, D, Collins, JL, Constantinou, M, Contalbrigo, M, Contin, G, Corliss, R, Cosyn, W, Courtoy, A, Crafts, J, Cruz-Torres, R, Cuevas, RC, D'Alesio, U, Torre, S Dalla, Das, D, Dasgupta, SS, Da Silva, C, Deconinck, W, Defurne, M, DeGraw, W, Dehmelt, K, Del Dotto, A, Delcarro, F, Deshpande, A, Detmold, W, De Vita, R, Diefenthaler, M, Dilks, C, Dixit, DU, Dulat, S, Dumitru, A, Dupré, R, and Durham, JM
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Nuclear and Plasma Physics ,Synchrotrons and Accelerators ,Physical Sciences ,Affordable and Clean Energy ,Astronomical and Space Sciences ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Astronomical sciences ,Nuclear and plasma physics ,Particle and high energy physics - Abstract
This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Collider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nuclei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were commissioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimental equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter.
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- 2022
7. Lattice Boltzmann simulations of Plasma Wakefield Acceleration
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Parise, Gianmarco, Cianchi, Alessandro, Del Dotto, Alessio, Guglietta, Fabio, Rossi, Andrea Renato, and Sbragaglia, Mauro
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Physics - Plasma Physics ,Physics - Computational Physics - Abstract
We explore a novel simulation route for Plasma Wakefield Acceleration (PWFA) by using the computational method known as the Lattice Boltzmann Method (LBM). LBM is based on a discretization of the continuum kinetic theory while assuring the convergence towards hydrodynamics for coarse-grained fields (i.e., density, velocity, etc.). LBM is an established numerical analysis tool in computational fluid dynamics, able to efficiently bridge between kinetic theory and hydrodynamics, but its application in the context of PWFA has never been investigated so far. This paper aims at filling this gap. Results of LBM simulations for PWFA are discussed and compared with those of a code (Architect) implementing a Cold Fluid (CF) model for the plasma. In the hydrodynamic framework, we discuss the importance of regularization effects related to diffusion properties intrinsic of the LBM, allowing to go beyond the traditional CF approximations. Issues on computational efficiency are also addressed.
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- 2022
- Full Text
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8. Light-Front Transverse Momentum Distributions for ${\cal J}$=1/2 Hadronic Systems in Valence Approximation
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Alessandro, Rocco, Del Dotto, Alessio, Pace, Emanuele, Perna, Gabriele, Salmè, Giovanni, and Scopetta, Sergio
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
The semi-inclusive correlator for a ${\cal J}$=1/2 bound-system, composed by A spin-1/2 fermions, is linearly expressed in terms of the light-front Poincar\'e covariant spin-dependent spectral function, in valence approximation. The light-front spin-dependent spectral function is fully determined by six scalar functions that allow for a complete description of the six T-even transverse-momentum distributions, suitable for a detailed investigation of the dynamics inside the bound system. The application of the developed formalism to a case with a sophisticated dynamical content, like $^3$He, reaches two goals: (i) to illustrate a prototype of an investigation path for gathering a rich wealth of information on the dynamics and also finding valuable constraints to be exploited from the phenomenological standpoint; (ii) to support for the three-nucleon system a dedicated experimental effort for obtaining a detailed 3D picture in momentum space. In particular, the orbital-angular momentum decomposition of the bound state can be studied through the assessment of relations among the transverse-momentum distributions, as well as the relevance of the relativistic effect generated by the implementation of macrocausality. A fresh evaluation of the longitudinal and transverse polarizations of the neutron and proton is also provided, confirming essentially the values used in the standard procedure for extracting the neutron structure functions from both deep-inelastic scattering and semi-inclusive reactions, in the same kinematical regime., Comment: 26 pages, 7 figures
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- 2021
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9. First emittance measurement of the beam-driven plasma wakefield accelerated electron beam
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Shpakov, V., Anania, M. P., Behtouei, M., Bellaveglia, M., Biagioni, A., Cesarini, M., Chiadroni, E., Cianchi, A., Costa, G., Croia, M., Del Dotto, A., Diomede, M., Dipace, F., Ferrario, M., Galletti, M., Giribono, A., Liedl, A., Lollo, V., Magnisi, L., Mostacci, A., Di Pirro, G., Piersanti, L., Pompili, R., Romeo, S., Rossi, A. R., Scifo, J., Vaccarezza, C., Villa, F., and Zigler, A.
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Physics - Accelerator Physics - Abstract
Next-generation plasma-based accelerators can push electron beams to GeV energies within centimetre distances. The plasma, excited by a driver pulse, is indeed able to sustain huge electric fields that can efficiently accelerate a trailing witness bunch, which was experimentally demonstrated on multiple occasions. Thus, the main focus of the current research is being shifted towards achieving a high quality of the beam after the plasma acceleration. In this letter we present beam-driven plasma wakefield acceleration experiment, where initially preformed high-quality witness beam was accelerated inside the plasma and characterized. In this experiment the witness beam quality after the acceleration was maintained on high level, with $0.2\%$ final energy spread and $3.8~\mu m$ resulting normalized transverse emittance after the acceleration. In this article, for the first time to our knowledge, the emittance of the PWFA beam was directly measured.
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- 2021
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10. Lipidomics reveals the reshaping of the mitochondrial phospholipid profile in cells lacking OPA1 and mitofusins
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Castellaneta, Andrea, Losito, Ilario, Porcelli, Vito, Barile, Serena, Maresca, Alessandra, Del Dotto, Valentina, Losacco, Valentina, Guadalupi, Ludovica Sofia, Calvano, Cosima Damiana, Chan, David C., Carelli, Valerio, Palmieri, Luigi, and Cataldi, Tommaso R.I.
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- 2024
- Full Text
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11. Science Requirements and Detector Concepts for the Electron-Ion Collider: EIC Yellow Report
- Author
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Khalek, R. Abdul, Accardi, A., Adam, J., Adamiak, D., Akers, W., Albaladejo, M., Al-bataineh, A., Alexeev, M. G., Ameli, F., Antonioli, P., Armesto, N., Armstrong, W. R., Arratia, M., Arrington, J., Asaturyan, A., Asai, M., Aschenauer, E. C., Aune, S., Avagyan, H., Gayoso, C. Ayerbe, Azmoun, B., Bacchetta, A., Baker, M. D., Barbosa, F., Barion, L., Barish, K. N., Barry, P. C., Battaglieri, M., Bazilevsky, A., Behera, N. K., Benmokhtar, F., Berdnikov, V. V., Bernauer, J. C., Bertone, V., Bhattacharya, S., Bissolotti, C., Boer, D., Boglione, M., Bondì, M., Boora, P., Borsa, I., Bossù, F., Bozzi, G., Brandenburg, J. D., Brei, N., Bressan, A., Brooks, W. K., Bufalino, S., Bukhari, M. H. S., Burkert, V., Buttimore, N. H., Camsonne, A., Celentano, A., Celiberto, F. G., Chang, W., Chatterjee, C., Chen, K., Chetry, T., Chiarusi, T., Chien, Y. -T., Chiosso, M., Chu, X., Chudakov, E., Cicala, G., Cisbani, E., Cloet, I. C., Cocuzza, C., Cole, P. L., Colella, D., Collins II, J. L., Constantinou, M., Contalbrigo, M., Contin, G., Corliss, R., Cosyn, W., Courtoy, A., Crafts, J., Cruz-Torres, R., Cuevas, R. C., D'Alesio, U., Torre, S. Dalla, Das, D., Dasgupta, S. S., Da Silva, C., Deconinck, W., Defurne, M., DeGraw, W., Dehmelt, K., Del Dotto, A., Delcarro, F., Deshpande, A., Detmold, W., De Vita, R., Diefenthaler, M., Dilks, C., Dixit, D. U., Dulat, S., Dumitru, A., Dupré, R., Durham, J. M., Echevarria, M. G., Fassi, L. El, Elia, D., Ent, R., Esha, R., Ethier, J. J., Evdokimov, O., Eyser, K. O., Fanelli, C., Fatemi, R., Fazio, S., Fernandez-Ramirez, C., Finger, M., Finger Jr., M., Fitzgerald, D., Flore, C., Frederico, T., Friščić, I., Fucini, S., Furletov, S., Furletova, Y., Gal, C., Gamberg, L., Gao, H., Garg, P., Gaskell, D., Gates, K., Ducati, M. B. Gay, Gericke, M., da Silveira, G. Gil, Girod, F. -X., Glazier, D. I., Gnanvo, K., Goncalves, V. P., Gonella, L., Hernandez, J. O. Gonzalez, Goto, Y., Grancagnolo, F., Greiner, L. C., Guryn, W., Guzey, V., Hatta, Y., Hattawy, M., Hauenstein, F., He, X., Hemmick, T. K., Hen, O., Heyes, G., Higinbotham, D. W., Blin, A. N. Hiller, Hobbs, T. J., Hohlmann, M., Horn, T., Hou, T. -J., Huang, J., Huang, Q., Huber, G. M., Hyde, C. E., Iakovidis, G., Ilieva, Y., Jacak, B. V., Jacobs, P. M., Jadhav, M., Janoska, Z., Jentsch, A., Jezo, T., Jing, X., Jones, P. G., Joo, K., Joosten, S., Kafka, V., Kalantarians, N., Kalicy, G., Kang, D., Kang, Z. B., Kauder, K., Kay, S. J. D., Keppel, C. E., Kim, J., Kiselev, A., Klasen, M., Klein, S., Klest, H. T., Korchak, O., Kostina, A., Kotko, P., Kovchegov, Y. V., Krelina, M., Kuleshov, S., Kumano, S., Kumar, K. S., Kumar, R., Kumar, L., Kumerički, K., Kusina, A., Kutak, K., Lai, Y. S., Lalwani, K., Lappi, T., Lauret, J., Lavinsky, M., Lawrence, D., Lednicky, D., Lee, C., Lee, K., Lee, S. H., Levorato, S., Li, H., Li, S., Li, W., Li, X., Li, W. B., Ligonzo, T., Liu, H., Liu, M. X., Liu, X., Liuti, S., Liyanage, N., Lorcé, C., Lu, Z., Lucero, G., Lukow, N. S., Lunghi, E., Majka, R., Makris, Y., Mandjavidze, I., Mantry, S., Mäntysaari, H., Marhauser, F., Markowitz, P., Marsicano, L., Mastroserio, A., Mathieu, V., Mehtar-Tani, Y., Melnitchouk, W., Mendez, L., Metz, A., Meziani, Z. -E., Mezrag, C., Mihovilovič, M., Milner, R., Mirazita, M., Mkrtchyan, H., Mkrtchyan, A., Mochalov, V., Moiseev, V., Mondal, M. M., Morreale, A., Morrison, D., Motyka, L., Moutarde, H., Camacho, C. Muñoz, Murgia, F., Murray, M. J., Musico, P., Nadel-Turonski, P., Nadolsky, P. M., Nam, J., Newman, P. R., Neyret, D., Nguyen, D., Nocera, E. R., Noferini, F., Noto, F., Nunes, A. S., Okorokov, V. A., Olness, F., Osborn, J. D., Page, B. S., Park, S., Parker, A., Paschke, K., Pasquini, B., Paukkunen, H., Paul, S., Pecar, C., Pegg, I. L., Pellegrino, C., Peng, C., Pentchev, L., Perrino, R., Petriello, F., Petti, R., Pilloni, A., Pinkenburg, C., Pire, B., Pisano, C., Pitonyak, D., Poblaguev, A. A., Polakovic, T., Posik, M., Potekhin, M., Preghenella, R., Preins, S., Prokudin, A., Pujahari, P., Purschke, M. L., Pybus, J. R., Radici, M., Rajput-Ghoshal, R., Reimer, P. E., Rinaldi, M., Ringer, F., Roberts, C. D., Rodini, S., Rojo, J., Romanov, D., Rossi, P., Santopinto, E., Sarsour, M., Sassot, R., Sato, N., Schenke, B., Schmidke, W. B., Schmidt, I., Schmidt, A., Schmookler, B., Schnell, G., Schweitzer, P., Schwiening, J., Scimemi, I., Scopetta, S., Segovia, J., Seidl, R., Sekula, S., Semenov-Tian-Shanskiy, K., Shao, D. Y., Sherrill, N., Sichtermann, E., Siddikov, M., Signori, A., Singh, B. K., Širca, S., Slifer, K., Slominski, W., Sokhan, D., Sondheim, W. E., Song, Y., Soto, O., Spiesberger, H., Stasto, A. M., Stepanov, P., Sterman, G., Stevens, J. R., Stewart, I. W., Strakovsky, I., Strikman, M., Sturm, M., Stutzman, M. L., Sullivan, M., Surrow, B., Svihra, P., Syritsyn, S., Szczepaniak, A., Sznajder, P., Szumila-Vance, H., Szymanowski, L., Tadepalli, A. S., Takaki, J. D. Tapia, Tassielli, G. F., Terry, J., Tessarotto, F., Tezgin, K., Tomasek, L., Acosta, F. Torales, Tribedy, P., Tricoli, A., Triloki, Tripathi, S., Trotta, R. L., Tsai, O. D., Tu, Z., Tuvè, C., Ullrich, T., Ungaro, M., Urciuoli, G. M., Valentini, A., Vancura, P., Vandenbroucke, M., Van Hulse, C., Varner, G., Venugopalan, R., Vitev, I., Vladimirov, A., Volpe, G., Vossen, A., Voutier, E., Wagner, J., Wallon, S., Wang, H., Wang, Q., Wang, X., Wei, S. Y., Weiss, C., Wenaus, T., Wennlöf, H., Wickramaarachchi, N., Wikramanayake, A., Winney, D., Wong, C. P., Woody, C., Xia, L., Xiao, B. W., Xie, J., Xing, H., Xu, Q. H., Zhang, J., Zhang, S., Zhang, Z., Zhao, Z. W., Zhao, Y. X., Zheng, L., Zhou, Y., and Zurita, P.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology ,Nuclear Experiment ,Nuclear Theory - Abstract
This report describes the physics case, the resulting detector requirements, and the evolving detector concepts for the experimental program at the Electron-Ion Collider (EIC). The EIC will be a powerful new high-luminosity facility in the United States with the capability to collide high-energy electron beams with high-energy proton and ion beams, providing access to those regions in the nucleon and nuclei where their structure is dominated by gluons. Moreover, polarized beams in the EIC will give unprecedented access to the spatial and spin structure of the proton, neutron, and light ions. The studies leading to this document were commissioned and organized by the EIC User Group with the objective of advancing the state and detail of the physics program and developing detector concepts that meet the emerging requirements in preparation for the realization of the EIC. The effort aims to provide the basis for further development of concepts for experimental equipment best suited for the science needs, including the importance of two complementary detectors and interaction regions. This report consists of three volumes. Volume I is an executive summary of our findings and developed concepts. In Volume II we describe studies of a wide range of physics measurements and the emerging requirements on detector acceptance and performance. Volume III discusses general-purpose detector concepts and the underlying technologies to meet the physics requirements. These considerations will form the basis for a world-class experimental program that aims to increase our understanding of the fundamental structure of all visible matter, Comment: 902 pages, 415 authors, 151 institutions
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- 2021
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12. Energy spread minimization in a beam-driven plasma wakefield accelerator
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Pompili, R., Anania, M. P., Behtouei, M., Bellaveglia, M., Biagioni, A., Bisesto, F. G., Cesarini, M., Chiadroni, E., Cianchi, A., Costa, G., Croia, M., Del Dotto, A., Di Giovenale, D., Diomede, M., Dipace, F., Ferrario, M., Giribono, A., Lollo, V., Magnisi, L., Marongiu, M., Mostacci, A., Di Pirro, G., Romeo, S., Rossi, A. R., Scifo, J., Shpakov, V., Vaccarezza, C., Villa, F., and Zigler, A.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Next-generation plasma-based accelerators can push electron bunches to gigaelectronvolt energies within centimetre distances. The plasma, excited by a driver pulse, generates large electric fields that can efficiently accelerate a trailing witness bunch making possible the realization of laboratory-scale applications ranging from high-energy colliders to ultra-bright light sources. So far several experiments have demonstrated a significant acceleration but the resulting beam quality, especially the energy spread, is still far from state of the art conventional accelerators. Here we show the results of a beam-driven plasma acceleration experiment where we used an electron bunch as a driver followed by an ultra-short witness. The experiment demonstrates, for the first time, an innovative method to achieve an ultra-low energy spread of the accelerated witness of about 0.1%. This is an order of magnitude smaller than what has been obtained so far. The result can lead to a major breakthrough toward the optimization of the plasma acceleration process and its implementation in forthcoming compact machines for user-oriented applications.
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- 2020
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13. Genetic variants affecting NQO1 protein levels impact the efficacy of idebenone treatment in Leber hereditary optic neuropathy
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Aleo, Serena Jasmine, Del Dotto, Valentina, Romagnoli, Martina, Fiorini, Claudio, Capirossi, Giada, Peron, Camille, Maresca, Alessandra, Caporali, Leonardo, Capristo, Mariantonietta, Tropeano, Concetta Valentina, Zanna, Claudia, Ross-Cisneros, Fred N., Sadun, Alfredo A., Pignataro, Maria Gemma, Giordano, Carla, Fasano, Chiara, Cavaliere, Andrea, Porcelli, Anna Maria, Tioli, Gaia, Musiani, Francesco, Catania, Alessia, Lamperti, Costanza, Marzoli, Stefania Bianchi, De Negri, Annamaria, Cascavilla, Maria Lucia, Battista, Marco, Barboni, Piero, Carbonelli, Michele, Amore, Giulia, La Morgia, Chiara, Smirnov, Dmitrii, Vasilescu, Catalina, Farzeen, Aiman, Blickhaeuser, Beryll, Prokisch, Holger, Priglinger, Claudia, Livonius, Bettina, Catarino, Claudia B., Klopstock, Thomas, Tiranti, Valeria, Carelli, Valerio, and Ghelli, Anna Maria
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- 2024
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14. The pro-oncogenic protein IF1 does not contribute to the Warburg effect and is not regulated by PKA in cancer cells
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Sgarbi, Gianluca, Righetti, Riccardo, Del Dotto, Valentina, Grillini, Silvia, Giorgio, Valentina, Baracca, Alessandra, and Solaini, Giancarlo
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- 2024
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15. Methyl carbamates of phosphatidylethanolamines and phosphatidylserines reveal bacterial contamination in mitochondrial lipid extracts of mouse embryonic fibroblasts
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Andrea Castellaneta, Vito Porcelli, Ilario Losito, Serena Barile, Alessandra Maresca, Valentina Del Dotto, Ludovica Sofia Guadalupi, Cosima Damiana Calvano, Valerio Carelli, Luigi Palmieri, and Tommaso R. I. Cataldi
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Medicine ,Science - Abstract
Abstract The occurrence of methyl carbamates of phosphatidylethanolamines and phosphatidylserines in the lipid extract of mitochondria obtained from mouse embryonic fibroblasts was ascertained by hydrophilic interaction liquid chromatography with electrospray ionization single and multi-stage mass spectrometry, performed using sinergically a high resolution (quadrupole-Orbitrap) and a low resolution (linear ion trap) spectrometer. Two possible routes to the synthesis of methyl carbamates of phospholipids were postulated and evaluated: (i) a chemical transformation involving phosgene, occurring as a photooxidation by-product in the chloroform used for lipid extraction, and methanol, also used for the latter; (ii) an enzymatic methoxycarbonylation reaction due to an accidental bacterial contamination, that was unveiled subsequently on the murine mitochondrial sample. A specific lipid extraction performed on a couple of standard phosphatidyl-ethanolamines/-serines, based on purposely photo-oxidized chloroform and deuterated methanol, indicated route (i) as negligible in the specific case, thus highlighting the enzymatic route related to bacterial contamination as the most likely source of methyl carbamates. The unambiguous recognition of the latter might represent the starting point toward a better understanding of their generation in biological systems and a minimization of their occurrence when an artefactual formation is ascertained.
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- 2023
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16. AI-optimized detector design for the future Electron-Ion Collider: the dual-radiator RICH case
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Cisbani, E., Del Dotto, A., Fanelli, C., Williams, M., Alfred, M., Barbosa, F., Barion, L., Berdnikov, V., Brooks, W., Cao, T., Contalbrigo, M., Danagoulian, S., Datta, A., Demarteau, M., Denisov, A., Diefenthaler, M., Durum, A., Fields, D., Furletova, Y., Gleason, C., Grosse-Perdekamp, M., Hattawy, M., He, X., van Hecke, H., Higinbotham, D., Horn, T., Hyde, C., Ilieva, Y., Kalicy, G., Kebede, A., Kim, B., Liu, M., McKisson, J., Mendez, R., Nadel-Turonski, P., Pegg, I., Romanov, D., Sarsour, M., da Silva, C. L., Stevens, J., Sun, X., Syed, S., Towell, R., Xie, J., Zhao, Z. W., Zihlmann, B., and Zorn, C.
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Physics - Instrumentation and Detectors ,Computer Science - Machine Learning ,High Energy Physics - Experiment - Abstract
Advanced detector R&D requires performing computationally intensive and detailed simulations as part of the detector-design optimization process. We propose a general approach to this process based on Bayesian optimization and machine learning that encodes detector requirements. As a case study, we focus on the design of the dual-radiator Ring Imaging Cherenkov (dRICH) detector under development as part of the particle-identification system at the future Electron-Ion Collider (EIC). The EIC is a US-led frontier accelerator project for nuclear physics, which has been proposed to further explore the structure and interactions of nuclear matter at the scale of sea quarks and gluons. We show that the detector design obtained with our automated and highly parallelized framework outperforms the baseline dRICH design within the assumptions of the current model. Our approach can be applied to any detector R&D, provided that realistic simulations are available., Comment: 22 pages, 11 figures
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- 2019
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17. Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab -- 2018 update to PR12-16-001
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Battaglieri, M., Bersani, A., Bracco, G., Caiffi, B., Celentano, A., De Vita, R., Marsicano, L., Musico, P., Panza, F., Ripani, M., Santopinto, E., Taiuti, M., Bellini, V., Bondi', M., Castorina, P., De Napoli, M., Italiano, A., Kuznetzov, V., Leonora, E., Mammoliti, F., Randazzo, N., Re, L., Russo, G., Russo, M., Shahinyan, A., Sperduto, M., Spinali, S., Sutera, C., Tortorici, F., Baltzell, N., Dalton, M., Freyberger, A., Girod, F. -X., Kharashvili, G., Kubarovsky, V., Pasyuk, E., Smith, E. S., Stepanyan, S., Szumilla-Vance, H., Ungaro, M., Whitlatch, T., Izaguirre, E., Krnjaic, G., Ehle, I., Snowden-Ifft, D., Loomba, D., Carpinelli, M., D'Urso, D., Gabrieli, A., Maccioni, G., Sant, M., Sipala, V., Ameli, F., Cisbani, E., De Persio, F., Del Dotto, A., Garibaldi, F., Meddi, F., Nicolau, C. A., Urciuoli, G. M., Chiarusi, T., Manzali, M., Pellegrino, C., Schuster, P., Toro, N., Essig, R., Wood, M. H., Holtrop., M., Paremuzyan, R., De Cataldo, G., De Leo, R., Di Bari, D., Lagamba, L., Nappi, E., Perrino, R., Balossino, I., Barion, L., Ciullo, G., Contalbrigo, M., Drago, A., Lenisa, P., Movsisyan, A., Pappalardo, L., Spizzo, F., Turisini, M., Hasch, D., Lucherini, V., Mirazita, M., Pisano, S., Rossi, P., Tomassini, S., Simi, G., D'Angelo, A., Lanza, L., Rizzo, A., Filippi, A., Genovese, M., Kunkel, M., Bashkanov, M., Murphy, A., Smith, G., Watts, D., Zachariou, N., Zana, L., Glazier, D., Ireland, D., McKinnon, B., Sokhan, D., Colaneri, L., Pereira, S. Anefalos, Afanasev, A., Briscoe, B., Strakovsky, I., Kalantarians, N., Weinstein, L., Adhikari, K. P., Dunne, J. A., Dutta, D., Fassi, L. El, Ye, L., Hicks, K., Cole, P., Dobbs, S., Fanelli, C., and Mohanmurthy, P.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
This document complements and completes what was submitted last year to PAC45 as an update to the proposal PR12-16-001 "Dark matter search in a Beam-Dump eXperiment (BDX)" at Jefferson Lab submitted to JLab-PAC44 in 2016. Following the suggestions contained in the PAC45 report, in coordination with the lab, we ran a test to assess the beam-related backgrounds and validate the simulation framework used to design the BDX experiment. Using a common Monte Carlo framework for the test and the proposed experiment, we optimized the selection cuts to maximize the reach considering simultaneously the signal, cosmic-ray background (assessed in Catania test with BDX-Proto) and beam-related backgrounds (irreducible NC and CC neutrino interactions as determined by simulation). Our results confirmed what was presented in the original proposal: with 285 days of a parasitic run at 65 $\mu$A (corresponding to $10^{22}$ EOT) the BDX experiment will lower the exclusion limits in the case of no signal by one to two orders of magnitude in the parameter space of dark-matter coupling versus mass.
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- 2019
18. Plasma lens-based beam extraction and removal system for Plasma Wakefield Acceleration experiments
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Pompili, R., Chiadroni, E., Cianchi, A., Del Dotto, A., Faillace, L., Ferrario, M., Iovine, P., and Masullo, M. R.
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Physics - Accelerator Physics ,Physics - Plasma Physics - Abstract
Plasma Wakefield Acceleration represents one of the most promising techniques able to overcome the limits of conventional RF technology and make possible the development of compact accelerators. With respect to the laser-driven schemes, the beam-driven scenario is not limited by diffraction and dephasing issues, thus it allows to achieve larger acceleration lengths. One of the most prominent drawback, conversely, occurs at the end of the acceleration process and consists of removing the depleted high-charge driver while preserving the main features (emittance and peak current) of the accelerated witness bunch. Here we present a theoretical study demonstrating the possibility to reach these goals by using an innovative system consisting of an array of beam collimators and discharge-capillaries operating as active-plasma lenses. Such a system allows to extract and transport the accelerated and highly divergent witness bunch and, at the same time, provides for the removal of the driver. The study is completed by a set of numerical simulations conducted for different beam configurations. The physics of the interaction of particles with collimator is also investigated.
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- 2019
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19. Analytical study of low energy proton interactions in the SORGENTINA’s fusion ion source-Part II: beam-gas: SORGENTINA ion beam interactions
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Pietropaolo, A., Del Dotto, A., and Contessa, G. M.
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- 2023
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20. Seeing Merit as a Vehicle for Opportunity and Equity: Youth Respond to School Choice Policy
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Phillippo, Kate, Griffin, Briellen, Del Dotto, B. Jacob, Lennix, Crystal, and Tran, Ha
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School choice policy is ubiquitous in urban school districts. Evidence suggests that it has not fully delivered on its proponents' promises of equitable educational opportunity. While scholars and policymakers scrutinize data to determine school choice's equity outcomes, little attention has been paid to how school choice policy directly influences youth understanding of educational equity and opportunity. This study therefore explores how youth who engage with school choice policy come to understand and act upon the distribution of educational opportunities, and the extent to which their understandings and actions vary by social identity, family resources, school resources and admissions outcomes. 36 youth, engaged in the high school choice process, participated in this study, which is guided by policy enactment theory. Across subgroups, participants overwhelmingly valued merit as the best principle by which to distribute educational opportunity. Alongside this near-universal embrace of merit and widespread participation in choice policy-required actions, those who accessed the highest-performing schools often did so by activating non-academic resources that required financial capital. These findings highlight a shared ritual that serves to instantiate and reinforce ideals of meritocracy. Findings inform our discussion of school choice policy's educational equity and civic implications.
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- 2021
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21. Analytical study of low energy proton interactions in the SORGENTINA’s fusion ion source-part I: beam-dump
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Pietropaolo, A., Del Dotto, A., and Contessa, G. M.
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- 2023
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22. Rapamycin rescues mitochondrial dysfunction in cells carrying the m.8344A > G mutation in the mitochondrial tRNALys
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Mariantonietta Capristo, Valentina Del Dotto, Concetta Valentina Tropeano, Claudio Fiorini, Leonardo Caporali, Chiara La Morgia, Maria Lucia Valentino, Monica Montopoli, Valerio Carelli, and Alessandra Maresca
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MERRF ,Mitochondrial DNA ,Niacin ,PGC-1α ,Rapamycin ,mTORC1 ,Therapeutics. Pharmacology ,RM1-950 ,Biochemistry ,QD415-436 - Abstract
Abstract Background Myoclonus, Epilepsy and Ragged-Red-Fibers (MERRF) is a mitochondrial encephalomyopathy due to heteroplasmic mutations in mitochondrial DNA (mtDNA) most frequently affecting the tRNA Lys gene at position m.8344A > G. Defective tRNALys severely impairs mitochondrial protein synthesis and respiratory chain when a high percentage of mutant heteroplasmy crosses the threshold for full-blown clinical phenotype. Therapy is currently limited to symptomatic management of myoclonic epilepsy, and supportive measures to counteract muscle weakness with co-factors/supplements. Methods We tested two therapeutic strategies to rescue mitochondrial function in cybrids and fibroblasts carrying different loads of the m.8344A > G mutation. The first strategy was aimed at inducing mitochondrial biogenesis directly, over-expressing the master regulator PGC-1α, or indirectly, through the treatment with nicotinic acid, a NAD+ precursor. The second was aimed at stimulating the removal of damaged mitochondria through prolonged rapamycin treatment. Results The first approach slightly increased mitochondrial protein expression and respiration in the wild type and intermediate-mutation load cells, but was ineffective in high-mutation load cell lines. This suggests that induction of mitochondrial biogenesis may not be sufficient to rescue mitochondrial dysfunction in MERRF cells with high-mutation load. The second approach, when administered chronically (4 weeks), induced a slight increase of mitochondrial respiration in fibroblasts with high-mutation load, and a significant improvement in fibroblasts with intermediate-mutation load, rescuing completely the bioenergetics defect. This effect was mediated by increased mitochondrial biogenesis, possibly related to the rapamycin-induced inhibition of the Mechanistic Target of Rapamycin Complex 1 (mTORC1) and the consequent activation of the Transcription Factor EB (TFEB). Conclusions Overall, our results point to rapamycin-based therapy as a promising therapeutic option for MERRF.
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- 2022
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23. Pathological mitophagy disrupts mitochondrial homeostasis in Leber’s hereditary optic neuropathy
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Danese, Alberto, Patergnani, Simone, Maresca, Alessandra, Peron, Camille, Raimondi, Andrea, Caporali, Leonardo, Marchi, Saverio, La Morgia, Chiara, Del Dotto, Valentina, Zanna, Claudia, Iannielli, Angelo, Segnali, Alice, Di Meo, Ivano, Cavaliere, Andrea, Lebiedzinska-Arciszewska, Magdalena, Wieckowski, Mariusz R., Martinuzzi, Andrea, Moraes-Filho, Milton N., Salomao, Solange R., Berezovsky, Adriana, Belfort, Rubens, Jr., Buser, Christopher, Ross-Cisneros, Fred N., Sadun, Alfredo A., Tacchetti, Carlo, Broccoli, Vania, Giorgi, Carlotta, Tiranti, Valeria, Carelli, Valerio, and Pinton, Paolo
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- 2022
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24. Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab: an update on PR12-16-001
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Battaglieri, M., Bersani, A., Bracco, G., Caiffi, B., Celentano, A., De Vita, R., Marsicano, L., Musico, P., Osipenko, M., Panza, F., Ripani, M., Santopinto, E., Taiuti, M., Bellini, V., Bondi', M., Castorina, P., De Napoli, M., Italiano, A., Kuznetzov, V., Leonora, E., Mammoliti, F., Randazzo, N., Re, L., Russo, G., Russo, M., Shahinyan, A., Sperduto, M., Spinali, S., Sutera, C., Tortorici, F., Baltzell, N., Dalton, M., Freyberger, A., Girod, F. -X., Kharashvili, G., Kubarovsky, V., Pasyuk, E., Smith, E. S., Stepanyan, S., Ungaro, M., Whitlatch, T., Izaguirre, E., Krnjaic, G., Snowden-Ifft, D., Loomba, D., Carpinelli, M., D'Urso, D., Gabrieli, A., Maccioni, G., Sant, M., Sipala, V., Ameli, F., Cisbani, E., De Persio, F., Del Dotto, A., Garibaldi, F., Meddi, F., Nicolau, C. A., Urciuoli, G. M., Chiarusi, T., Manzali, M., Pellegrino, C., Schuster, P., Toro, N., Essig, R., Wood, M. H., Paremuzyan, M. Holtrop. R., De Cataldo, G., De Leo, R., Di Bari, D., Lagamba, L., Nappi, E., Perrino, R., Balossino, I., Barion, L., Ciullo, G., Contalbrigo, M., Drago, A., Lenisa, P., Movsisyan, A., Pappalardo, L., Spizzo, F., Turisini, M., Hasch, D., Lucherini, V., Mirazita, M., Pisano, S., Rossi, P., Tomassini, S., Simi, G., D'Angelo, A., Lanza, L., Rizzo, A., Schaerf, C., Zonta, I., Filippi, A., Genovese, M., Fegan, S., Kunkel, M., Bashkanov, M., Murphy, A., Smith, G., Watts, D., Zachariou, N., Zana, L., Glazier, D., Ireland, D., McKinnon, B., Sokhan, D., Colaneri, L., Pereira, S. Anefalos, Afanasev, A., Briscoe, B., Strakovsky, I., Kalantarians, N., Weinstein, L., Adhikari, K. P., Dunne, J. A., Dutta, D., Fassi, L. El, Ye, L., Hicks, K., Cole, P., Dobbs, S., Fanelli, C., and Murthy, P. T. M.
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Physics - Instrumentation and Detectors ,High Energy Physics - Experiment - Abstract
This document is an update to the proposal PR12-16-001 Dark matter search in a Beam-Dump eXperiment (BDX) at Jefferson Lab submitted to JLab-PAC44 in 2016 reporting progress in addressing questions raised regarding the beam-on backgrounds. The concerns are addressed by adopting a new simulation tool, FLUKA, and planning measurements of muon fluxes from the dump with its existing shielding around the dump. First, we have implemented the detailed BDX experimental geometry into a FLUKA simulation, in consultation with experts from the JLab Radiation Control Group. The FLUKA simulation has been compared directly to our GEANT4 simulations and shown to agree in regions of validity. The FLUKA interaction package, with a tuned set of biasing weights, is naturally able to generate reliable particle distributions with very small probabilities and therefore predict rates at the detector location beyond the planned shielding around the beam dump. Second, we have developed a plan to conduct measurements of the muon ux from the Hall-A dump in its current configuration to validate our simulations., Comment: Document submitted to JLab PAC 45
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- 2017
25. Three--Dimensional parton structure of light nuclei
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Scopetta, Sergio, Del Dotto, Alessio, Kaptari, Leonid, Pace, Emanuele, Rinaldi, Matteo, and Salmè, Giovanni
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
Two promising directions beyond inclusive deep inelastic scattering experiments, aimed at unveiling the three dimensional structure of the bound nucleon, are reviewed, considering in particular the $^3$He nucleus. The 3D structure in coordinate space can be accessed through deep exclusive processes, whose non-perturbative part is encoded in generalized parton distributions (GPDs). In this way, the distribution of partons in the transverse plane can be obtained. As an example, coherent deeply virtual Compton scattering (DVCS) off $^3$He nuclei, important to access the neutron GPDs, will be discussed. In Impulse Approximation (IA), the sum of two GPDs of $^3$He, $H$ and $E$, at low momentum transfer, turns out to be dominated by the neutron contribution. Besides, a technique, able to take into account the nuclear effects included in the Impulse Approximation analysis, has been developed. The spin dependent GPD $\tilde H$ of $^3$He is also found to be largely dominated, at low momentum transfer, by the neutron contribution. Semi-inclusive deep inelastic scattering processes access the momentum space 3D structure parameterized through transverse momentum dependent parton distributions. A distorted spin-dependent spectral function has been recently introduced for $^3$He, in a non-relativistic framework, to take care of the final state interaction between the observed pion and the remnant in semi-inclusive deep inelastic electron scattering off transversely polarized $^3$He. The calculation of the Sivers and Collins single spin asymmetries for $^3$He, and a straightforward procedure to effectively take into account nuclear dynamics and final state interactions, will be reviewed. The Light-front dynamics generalization of the analysis is also addressed., Comment: 10 pages, 5 figures, invited talk at the "15th Conference on Theoretical Nuclear Physics in Italy (TNPI16)", Pisa, Italy, 20-22 April 2016. To appear in the Proceedings
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- 2017
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26. Neutron Parton Structure And The Light-Front Spectral Function Of 3He
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Pace, Emanuele, Del Dotto, Alessio, Kaptari, Leonid, Rinaldi, Matteo, Salmè, Giovanni, and Scopetta, Sergio
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Nuclear Theory ,High Energy Physics - Theory - Abstract
Semi-inclusive deep inelastic electron scattering off polarized 3He is studied in a non-relativistic framework, using a distorted spin-dependent spectral function for 3He to take care of the final state interaction between the observed pion and the remnant. A simple procedure is shown to be valuable for the extraction of Sivers and Collins asymmetries for the neutron fromthe corresponding asymmetries for 3He. To extend this study in a relativistic framework, a novel approach for a Poincar\'e covariant description of nuclear dynamics is presented, based on the light-front Hamiltonian dynamics. The key quantity is the light-front spectral function, where both normalization and momentum sum rule can be satisfied at the same time. Preliminary results are discussed for an initial analysis of the role of relativity in the EMC effect in 3He, and the generalization of the procedure for the extraction of neutron asymmetries within the light-front dynamics is outlined., Comment: Pages 8, figures 3. Talk given at the 26th International Nuclear Physics Conference, 11-16 September, 2016, Adelaide, Australia, to be published in Proceedings of Science. Comments added. arXiv admin note: text overlap with arXiv:1602.06521
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- 2017
27. Final state interactions and the extraction of neutron single spin asymmetries from SIDIS by a transversely polarized $^3$He target
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Del Dotto, A., Kaptari, L. P., Pace, E., Salmè, G., and Scopetta, S.
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
The semi-inclusive deep inelastic electron scattering off transversely polarized $^3$He, i.e. the process, $e + \vec{^3 {\rm He}} \to e' + h+X$, with $h$ a detected fast hadron, is studied beyond the plane wave impulse approximation. To this end, a distorted spin-dependent spectral function of a nucleon inside an A=3 nucleus is actually evaluated through a generalized eikonal approximation, in order to take into account the final state interactions between the hadronizing system and the (A-1) nucleon spectator one. Our realistic description of both nuclear target and final state is a substantial step forward for achieving a reliable extraction of the Sivers and Collins single spin asymmetries of the free neutron. To illustrate how and to what extent the model dependence due to the treatment of the nuclear effects is under control, we apply our approach to the extraction procedure of the neutron single spin asymmetries from those measured for $^3$He for values of the kinematical variables relevant both for forthcoming experiments at Jefferson Lab and, with an exploratory purpose, for the future Electron Ion Collider., Comment: 30 pages, 13 figures
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- 2017
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28. Free-electron lasing with compact beam-driven plasma wakefield accelerator
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Pompili, R., Alesini, D., Anania, M. P., Arjmand, S., Behtouei, M., Bellaveglia, M., Biagioni, A., Buonomo, B., Cardelli, F., Carpanese, M., Chiadroni, E., Cianchi, A., Costa, G., Del Dotto, A., Del Giorno, M., Dipace, F., Doria, A., Filippi, F., Galletti, M., Giannessi, L., Giribono, A., Iovine, P., Lollo, V., Mostacci, A., Nguyen, F., Opromolla, M., Di Palma, E., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Di Pirro, G., Romeo, S., Rossi, A. R., Scifo, J., Selce, A., Shpakov, V., Stella, A., Vaccarezza, C., Villa, F., Zigler, A., and Ferrario, M.
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- 2022
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29. Polarized $^3$He target and final state interactions in SiDIS
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Del Dotto, Alessio, Kaptari, Leonid, Pace, Emanuele, Salmè, Giovanni, and Scopetta, Sergio
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Nuclear Theory ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
Jefferson Lab (JLab) is starting a wide experimental program aimed at studying the neutron's structure, with a great emphasis on the extraction of the parton transverse-momentum distributions (TMDs). To this end, Semi-inclusive deep-inelastic scattering (SiDIS) experiments on polarized $^3$He will be carried out, providing, together with proton and deuteron data, a sound flavor decomposition of the TMDs. Given the expected high statistical accuracy, it is crucial to disentangle nuclear and partonic degrees of freedom to get an accurate theoretical description of both initial and final states. In this contribution, a preliminary study of the Final State Interaction (FSI) in the standard SiDIS, where a pion (or a Kaon) is detected in the final state is presented, in view of constructing a realistic description of the nuclear initial and final states., Comment: presented at The 23rd European Conference on Few-Body Problems in Physics, Aarhus, Denmark, 8-12 August 2016
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- 2016
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30. Light-Front spin-dependent Spectral Function and Nucleon Momentum Distributions for a Three-Body System
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Del Dotto, Alessio, Pace, Emanuele, Salmè, Giovanni, and Scopetta, Sergio
- Subjects
Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
Poincare' covariant definitions for the spin-dependent spectral function and for the momentum distributions within the light-front Hamiltonian dynamics are proposed for a three-fermion bound system, starting from the light-front wave function of the system. The adopted approach is based on the Bakamjian-Thomas construction of the Poincare' generators, that allows one to easily import the familiar and wide knowledge on the nuclear interaction into a light-front framework. The proposed formalism can find useful applications in refined nuclear calculations, like the ones needed for evaluating the EMC effect or the semi-inclusive deep inelastic cross sections with polarized nuclear targets, since remarkably the light-front unpolarized momentum distribution by definition fulfills both normalization and momentum sum rules. It is also shown a straightforward generalization of the definition of the light-front spectral function to an A-nucleon system.
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- 2016
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31. The 3He spectral function in light-front dynamics
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Rinaldi, Matteo, Del Dotto, Alessio, Kaptari, Leonid, Pace, Emanuele, Salmè, Giovanni, and Scopetta, Sergio
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
A distorted spin-dependent spectral function for 3He is considered for the extraction of the transverse-momentum dependent parton distributions in the neutron from semi-inclusive deep inelastic electron scattering off polarized 3He at finite momentum transfers, where final state interactions are taken into account. The generalization of the analysis to a Poincar\'e covariant framework within the light-front dynamics is outlined., Comment: 4 pages, 2 figures, talk given at the 21st International Conference on Few-Body Problems in Physics, Chicago, IL, May 18th-22nd, 2015; EPJ Web of Conference, in press
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- 2016
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32. Light-Front Dynamics and the 3He Spectral Function
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Pace, Emanuele, Del Dotto, Alessio, Kaptari, Leonid, Rinaldi, Matteo, Salme', Giovanni, and Scopetta, Sergio
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Nuclear Theory - Abstract
Two topics are presented. The first one is a novel approach for a Poincare' covariant description of nuclear dynamics based on light-front Hamiltonian dynamics. The key quantity is the light-front spectral function, where both normalization and momentum sum rule can be satisfied at the same time. Preliminary results are discussed for an initial analysis of the role of relativity in the EMC effect in 3He. A second issue, very challenging, is considered in a non-relativistic framework, namely a distorted spin-dependent spectral function for 3He in order to take care of the final state interaction between the observed pion and the remnant in semi-inclusive deep inelastic electron scattering off polarized 3He. The generalization of the analysis within the light-front dynamics is outlined., Comment: 6 pages, 2 figures, talk given at the Light Cone 2015 (LC2015) Conference, Frascati, Italy, September 21st - 25th, 2015. Comments added
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- 2016
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33. Guiding of Charged Particle Beams in Curved Plasma-Discharge Capillaries
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Pompili, R., primary, Anania, M. P., additional, Biagioni, A., additional, Carillo, M., additional, Chiadroni, E., additional, Cianchi, A., additional, Costa, G., additional, Curcio, A., additional, Crincoli, L., additional, Del Dotto, A., additional, Del Giorno, M., additional, Demurtas, F., additional, Frazzitta, A., additional, Galletti, M., additional, Giribono, A., additional, Lollo, V., additional, Opromolla, M., additional, Parise, G., additional, Pellegrini, D., additional, Di Pirro, G., additional, Romeo, S., additional, Rossi, A. R., additional, Silvi, G. J., additional, Verra, L., additional, Villa, F., additional, Zigler, A., additional, and Ferrario, M., additional
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- 2024
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34. A Light-Front approach to the $^3$He spectral function
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Scopetta, Sergio, Del Dotto, Alessio, Kaptari, Leonid, Pace, Emanuele, Rinaldi, Matteo, and Salmè, Giovanni
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Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
The analysis of semi-inclusive deep inelastic electron scattering off polarized $^3$He at finite momentum transfers, aimed at the extraction of the quark transverse-momentum distributions in the neutron, requires the use of a distorted spin-dependent spectral function for $^3$He, which takes care of the final state interaction effects. This quantity is introduced in the non-relativistic case, and its generalization in a Poincar\'e covariant framework, in plane wave impulse approximation for the moment being, is outlined. Studying the light-front spin-dependent spectral function for a J=1/2 system, such as the nucleon, it is found that, within the light-front dynamics with a fixed number of constituents and in the valence approximation, only three of the six leading twist T-even transverse-momentum distributions are independent., Comment: 6 pages, 1 figure, invited talk at the Conference "Light Cone 2014 (LC2014)", Raleigh, North Carolina, May 26-30, 2014. Submitted to Few-Body Systems
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- 2014
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35. The MOLLER Experiment: An Ultra-Precise Measurement of the Weak Mixing Angle Using M{\o}ller Scattering
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MOLLER Collaboration, Benesch, J., Brindza, P., Carlini, R. D., Chen, J-P., Chudakov, E., Covrig, S., Dalton, M. M., Deur, A., Gaskell, D., Gavalya, A., Gomez, J., Higinbotham, D. W., Keppel, C., Meekins, D., Michaels, R., Moffit, B., Roblin, Y., Suleiman, R., Wines, R., Wojtsekhowski, B., Cates, G., Crabb, D., Day, D., Gnanvo, K., Keller, D., Liyanage, N., Nelyubin, V. V., Nguyen, H., Norum, B., Paschke, K., Sulkosky, V., Zhang, J., Zheng, X., Birchall, J., Blunden, P., Gericke, M. T. W., Falk, W. R., Lee, L., Mammei, J., Page, S. A., van Oers, W. T. H., Dehmelt, K., Deshpande, A., Feege, N., Hemmick, T. K., Kumar, K. S., Kutz, T., Miskimen, R., Ramsey-Musolf, M. J., Riordan, S., Saylor, N. Hirlinger, Bessuille, J., Ihloff, E., Kelsey, J., Kowalski, S., Silwal, R., De Cataldo, G., De Leo, R., Di Bari, D., Lagamba, L., Bellini, E. NappiV., Mammoliti, F., Noto, F., Sperduto, M. L., Sutera, C. M., Cole, P., Forest, T. A., Khandekar, M., McNulty, D., Aulenbacher, K., Baunack, S., Maas, F., Tioukine, V., Gilman, R., Myers, K., Ransome, R., Tadepalli, A., Beniniwattha, R., Holmes, R., Souder, P., Armstrong, D. S., Averett, T. D., Deconinck, W., Duvall, W., Lee, A., Pitt, M. L., Dunne, J. A., Dutta, D., Fassi, L. El, De Persio, F., Meddi, F., Urciuoli, G. M., Cisbani, E., Fanelli, C., Garibaldi, F., Johnston, K., Simicevic, N., Wells, S., King, P. M., Roche, J., Arrington, J., Reimer, P. E., Franklin, G., Quinn, B., Ahmidouch, A., Danagoulian, S., Glamazdin, O., Pomatsalyuk, R., Mammei, R., Martin, J. W., Holmstrom, T., Erler, J., Kolomensky, Yu. G., Napolitano, J., Aniol, K. A., Ramsay, W. D., Korkmaz, E., Spayde, D. T., Benmokhtar, F., Del Dotto, A., Perrino, R., Barkanova, S., Aleksejevs, A., and Singh, J.
- Subjects
Nuclear Experiment ,High Energy Physics - Phenomenology - Abstract
The physics case and an experimental overview of the MOLLER (Measurement Of a Lepton Lepton Electroweak Reaction) experiment at the 12 GeV upgraded Jefferson Lab are presented. A highlight of the Fundamental Symmetries subfield of the 2007 NSAC Long Range Plan was the SLAC E158 measurement of the parity-violating asymmetry $A_{PV}$ in polarized electron-electron (M{\o}ller) scattering. The proposed MOLLER experiment will improve on this result by a factor of five, yielding the most precise measurement of the weak mixing angle at low or high energy anticipated over the next decade. This new result would be sensitive to the interference of the electromagnetic amplitude with new neutral current amplitudes as weak as $\sim 10^{-3}\cdot G_F$ from as yet undiscovered dynamics beyond the Standard Model. The resulting discovery reach is unmatched by any proposed experiment measuring a flavor- and CP-conserving process over the next decade, and yields a unique window to new physics at MeV and multi-TeV scales, complementary to direct searches at high energy colliders such as the Large Hadron Collider (LHC). The experiment takes advantage of the unique opportunity provided by the upgraded electron beam energy, luminosity, and stability at Jefferson Laboratory and the extensive experience accumulated in the community after a round of recent successfully completed parity-violating electron scattering experiments
- Published
- 2014
36. Towards an improved description of SiDIS by a polarized 3He target
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Del Dotto, Alessio, Kaptari, Leonid, Pace, Emanuele, Salme', Giovanni, and Scopetta, Sergio
- Subjects
Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
The possibility of improving the description of the semi-inclusive deep inelastic electron scattering off polarized 3He, that provides information on the neutron single spin asymmetries, is illustrated. In particular, the analysis at finite momentum transfers in a Poincare' covariant framework is outlined and a generalized eikonal approach to include final state interaction is presented., Comment: 4 pages, 2 figures, presented at The 22nd European Conference on Few Body Problems in Physics, Krakow, Poland, 9 - 13 September 2013
- Published
- 2014
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37. EuPRAXIA Conceptual Design Report
- Author
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Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Bründermann, E., Büscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chancé, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D’Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. M., Di Giovenale, D., Diomede, M., Di Pasquale, E., Di Pirro, G., Di Raddo, G., Dorda, U., Erlandson, A. C., Ertel, K., Esposito, A., Falcoz, F., Falone, A., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fils, J., Fiore, G., Fiorito, R., Fonseca, R. A., Franzini, G., Galimberti, M., Gallo, A., Galvin, T. C., Ghaith, A., Ghigo, A., Giove, D., Giribono, A., Gizzi, L. A., Grüner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Helm, A., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Hübner, M., Ibison, M., Incremona, S., Irman, A., Iungo, F., Jafarinia, F. J., Jakobsson, O., Jaroszynski, D. A., Jaster-Merz, S., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Kirchen, M., Kirwan, G., Kitégi, C., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Le Blanc, C., Lechner, C., Lee, P., Leemans, W., Lehrach, A., Li, X., Li, Y., Libov, V., Lifschitz, A., Lindstrøm, C. A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marcelli, A., Marchetti, B., Marcouillé, O., Marocchino, A., Marteau, F., Martinez de la Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Mironov, S., Molodozhentsev, A. Y., Morante, S., Mosnier, A., Mostacci, A., Müller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Nutter, A., Osterhoff, J., Oumbarek Espinos, D., Paillard, J. -L., Papadopoulos, D. N., Patrizi, B., Pattathil, R., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Reagan, B. A., Resta-Lopez, J., Ricci, R., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Rotundo, U., Roussel, E., Sabbatini, L., Santangelo, P., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sharma, G., Sheng, Z. M., Shpakov, V., Siders, C. W., Silva, L. O., Silva, T., Simon, C., Simon-Boisson, C., Sinha, U., Sistrunk, E., Specka, A., Spinka, T. M., Stecchi, A., Stella, A., Stellato, F., Streeter, M. J. V., Sutherland, A., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Valléau, M., Vannini, M., Vannozzi, A., Vescovi, S., Vieira, J. M., Villa, F., Wahlström, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, A., Welsch, C. P., Weng, S. M., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhang, H., Zhao, Y., Zhu, J., and Zigler, A.
- Published
- 2020
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38. Erratum to: EuPRAXIA Conceptual Design Report: Eur. Phys. J. Special Topics 229, 3675-4284 (2020), https://doi.org/10.1140/epjst/e2020-000127-8
- Author
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Assmann, R. W., Weikum, M. K., Akhter, T., Alesini, D., Alexandrova, A. S., Anania, M. P., Andreev, N. E., Andriyash, I., Artioli, M., Aschikhin, A., Audet, T., Bacci, A., Barna, I. F., Bartocci, S., Bayramian, A., Beaton, A., Beck, A., Bellaveglia, M., Beluze, A., Bernhard, A., Biagioni, A., Bielawski, S., Bisesto, F. G., Bonatto, A., Boulton, L., Brandi, F., Brinkmann, R., Briquez, F., Brottier, F., Bründermann, E., Büscher, M., Buonomo, B., Bussmann, M. H., Bussolino, G., Campana, P., Cantarella, S., Cassou, K., Chancé, A., Chen, M., Chiadroni, E., Cianchi, A., Cioeta, F., Clarke, J. A., Cole, J. M., Costa, G., Couprie, M. -E., Cowley, J., Croia, M., Cros, B., Crump, P. A., D’Arcy, R., Dattoli, G., Del Dotto, A., Delerue, N., Del Franco, M., Delinikolas, P., De Nicola, S., Dias, J. M., Di Giovenale, D., Diomede, M., Di Pasquale, E., Di Pirro, G., Di Raddo, G., Dorda, U., Erlandson, A. C., Ertel, K., Esposito, A., Falcoz, F., Falone, A., Fedele, R., Ferran Pousa, A., Ferrario, M., Filippi, F., Fils, J., Fiore, G., Fiorito, R., Fonseca, R. A., Franzini, G., Galimberti, M., Gallo, A., Galvin, T. C., Ghaith, A., Ghigo, A., Giove, D., Giribono, A., Gizzi, L. A., Grüner, F. J., Habib, A. F., Haefner, C., Heinemann, T., Helm, A., Hidding, B., Holzer, B. J., Hooker, S. M., Hosokai, T., Hübner, M., Ibison, M., Incremona, S., Irman, A., Iungo, F., Jafarinia, F. J., Jakobsson, O., Jaroszynski, D. A., Jaster-Merz, S., Joshi, C., Kaluza, M., Kando, M., Karger, O. S., Karsch, S., Khazanov, E., Khikhlukha, D., Kirchen, M., Kirwan, G., Kitégi, C., Knetsch, A., Kocon, D., Koester, P., Kononenko, O. S., Korn, G., Kostyukov, I., Kruchinin, K. O., Labate, L., Le Blanc, C., Lechner, C., Lee, P., Leemans, W., Lehrach, A., Li, X., Li, Y., Libov, V., Lifschitz, A., Lindstrøm, C. A., Litvinenko, V., Lu, W., Lundh, O., Maier, A. R., Malka, V., Manahan, G. G., Mangles, S. P. D., Marcelli, A., Marchetti, B., Marcouillé, O., Marocchino, A., Marteau, F., Martinez de la Ossa, A., Martins, J. L., Mason, P. D., Massimo, F., Mathieu, F., Maynard, G., Mazzotta, Z., Mironov, S., Molodozhentsev, A. Y., Morante, S., Mosnier, A., Mostacci, A., Müller, A. -S., Murphy, C. D., Najmudin, Z., Nghiem, P. A. P., Nguyen, F., Niknejadi, P., Nutter, A., Osterhoff, J., Oumbarek Espinos, D., Paillard, J. -L., Papadopoulos, D. N., Patrizi, B., Pattathil, R., Pellegrino, L., Petralia, A., Petrillo, V., Piersanti, L., Pocsai, M. A., Poder, K., Pompili, R., Pribyl, L., Pugacheva, D., Reagan, B. A., Resta-Lopez, J., Ricci, R., Romeo, S., Rossetti Conti, M., Rossi, A. R., Rossmanith, R., Rotundo, U., Roussel, E., Sabbatini, L., Santangelo, P., Sarri, G., Schaper, L., Scherkl, P., Schramm, U., Schroeder, C. B., Scifo, J., Serafini, L., Sharma, G., Sheng, Z. M., Shpakov, V., Siders, C. W., Silva, L. O., Silva, T., Simon, C., Simon-Boisson, C., Sinha, U., Sistrunk, E., Specka, A., Spinka, T. M., Stecchi, A., Stella, A., Stellato, F., Streeter, M. J. V., Sutherland, A., Svystun, E. N., Symes, D., Szwaj, C., Tauscher, G. E., Terzani, D., Toci, G., Tomassini, P., Torres, R., Ullmann, D., Vaccarezza, C., Valléau, M., Vannini, M., Vannozzi, A., Vescovi, S., Vieira, J. M., Villa, F., Wahlström, C. -G., Walczak, R., Walker, P. A., Wang, K., Welsch, A., Welsch, C. P., Weng, S. M., Wiggins, S. M., Wolfenden, J., Xia, G., Yabashi, M., Zhang, H., Zhao, Y., Zhu, J., and Zigler, A.
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- 2020
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39. Cigarette toxicity triggers Leber's hereditary optic neuropathy by affecting mtDNA copy number, oxidative phosphorylation and ROS detoxification pathways.
- Author
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Giordano, L, Deceglie, S, d'Adamo, P, Valentino, ML, La Morgia, C, Fracasso, F, Roberti, M, Cappellari, M, Petrosillo, G, Ciaravolo, S, Parente, D, Giordano, C, Maresca, A, Iommarini, L, Del Dotto, V, Ghelli, AM, Salomao, SR, Berezovsky, A, Belfort, R, Sadun, AA, Carelli, V, Loguercio Polosa, P, and Cantatore, P
- Subjects
Humans ,Optic Atrophy ,Hereditary ,Leber ,Reactive Oxygen Species ,DNA ,Mitochondrial ,Smoking ,Oxidative Phosphorylation ,Female ,Male ,Optic Atrophy ,Hereditary ,Leber ,DNA ,Mitochondrial ,Biochemistry and Cell Biology ,Oncology and Carcinogenesis - Abstract
Leber's hereditary optic neuropathy (LHON), the most frequent mitochondrial disease, is associated with mitochondrial DNA (mtDNA) point mutations affecting Complex I subunits, usually homoplasmic. This blinding disorder is characterized by incomplete penetrance, possibly related to several genetic modifying factors. We recently reported that increased mitochondrial biogenesis in unaffected mutation carriers is a compensatory mechanism, which reduces penetrance. Also, environmental factors such as cigarette smoking have been implicated as disease triggers. To investigate this issue further, we first assessed the relationship between cigarette smoke and mtDNA copy number in blood cells from large cohorts of LHON families, finding that smoking was significantly associated with the lowest mtDNA content in affected individuals. To unwrap the mechanism of tobacco toxicity in LHON, we exposed fibroblasts from affected individuals, unaffected mutation carriers and controls to cigarette smoke condensate (CSC). CSC decreased mtDNA copy number in all cells; moreover, it caused significant reduction of ATP level only in mutated cells including carriers. This implies that the bioenergetic compensation in carriers is hampered by exposure to smoke derivatives. We also observed that in untreated cells the level of carbonylated proteins was highest in affected individuals, whereas the level of several detoxifying enzymes was highest in carriers. Thus, carriers are particularly successful in reactive oxygen species (ROS) scavenging capacity. After CSC exposure, the amount of detoxifying enzymes increased in all cells, but carbonylated proteins increased only in LHON mutant cells, mostly from affected individuals. All considered, it appears that exposure to smoke derivatives has a more deleterious effect in affected individuals, whereas carriers are the most efficient in mitigating ROS rather than recovering bioenergetics. Therefore, the identification of genetic modifiers that modulate LHON penetrance must take into account also the exposure to environmental triggers such as tobacco smoke.
- Published
- 2015
40. Distorted spin-dependent spectral function of an A=3 nucleus and semi-inclusive deep inelastic scattering processes
- Author
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Kaptari, L. P., Del Dotto, A., Pace, E., Salme', G., and Scopetta, S.
- Subjects
Nuclear Theory ,High Energy Physics - Experiment ,High Energy Physics - Phenomenology - Abstract
The distorted spin-dependent spectral function of a nucleon inside an A=3 nucleus is introduced as a novel tool for investigating the polarized electron scattering off polarized $^3$He in semi-inclusive DIS regime (SiDIS), going beyond the standard plane wave impulse approximation. This distribution function is applied to the study of the spectator SiDIS, $\vec{^3{\rm He}}(\vec e, e' ~{^2}{\rm H})X$, in order to properly take into account the final state interaction between the hadronizing quark and the detected deuteron, with the final goal of a more reliable extraction of the polarized parton-distribution $g_1(x)$ inside a bound proton. Our analysis allows to single out two well-defined kinematical regions where the experimental asymmetries could yield very interesting information: the region where the final state effects can be minimized, and therefore the direct access to the parton distributions in the proton is feasible, and the one where the final state interaction dominates, and the spectator SiDIS reactions can elucidate the mechanism of the quark hadronization itself. The perspectives of extending our approach i) to the mirror nucleus, $^3$H, for achieving a less model-dependent flavor decomposition, and ii) to the asymmetries measured in the standard SiDIS reactions, $\vec e + \vec{^3 {\rm He}} \to e' + h+X$ with $h$ a detected fast hadron, with the aim of extracting the neutron transversity, are discussed., Comment: 28 pages + 14 figures. Submitted to Phys. Rev. C
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- 2013
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41. Quark Transverse Momentum Distributions inside a nucleon : a Light-Front Hamiltonian Dynamics study
- Author
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Pace, Emanuele, Salme', Giovanni, Scopetta, Sergio, and Del Dotto, Alessio
- Subjects
High Energy Physics - Phenomenology ,Nuclear Theory - Abstract
Through an impulse approximation analysis of single spin Sivers and Collins asymmetries in the Bjorken limit, the possibility to extract the quark transverse-momentum distributions in the neutron from semi-inclusive deep inelastic electron scattering off polarized 3He is illustrated. The analysis is generalized to finite momentum transfers in a light-front Poincare' covariant framework, defining the light-front spin-dependent spectral function of a J=1/2 system. The definition of the light-front spin-dependent spectral function for constituent quarks in the nucleon allows us to show that, within the light-front dynamics, only three of the six leading twist T-even transverse-momentum distributions are independent.
- Published
- 2013
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42. Neutron Transverse-Momentum Distributions and Polarized 3He within Light-Front Hamiltonian Dynamics
- Author
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Pace, Emanuele, Salme', Giovanni, Scopetta, Sergio, Del Dotto, Alessio, and Rinaldi, Matteo
- Subjects
High Energy Physics - Phenomenology - Abstract
The possibility to extract the quark transverse-momentum distributions in the neutron from semi-inclusive deep inelastic electron scattering off polarized 3He is illustrated through an impulse approximation analysis in the Bjorken limit. The generalization of the analysis at finite momentum transfers in a Poincare' covariant framework is outlined. The definition of the light-front spin-dependent spectral function of a J=1/2 system allows us to show that within the light-front dynamics only three of the six leading twist T-even transverse-momentum distributions are independent., Comment: 4 pages, 2 figures, Presented at the 20th International IUPAP Conference on Few-Body Problems in Physics, 20 - 25 August, 2012, Fukuoka, Japan
- Published
- 2013
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43. Transversity studies with a polarized 3He target
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Del Dotto, A., Pace, E., Salme', G., and Scopetta, S.
- Subjects
Nuclear Theory ,High Energy Physics - Phenomenology - Abstract
A realistic study of the SiDIS process 3He(e,e'\pi)X in the Bjorken limit is briefly reviewed, showing that the nuclear effects, present in the extraction of the neutron information, are largely under theoretical control, within an Impulse-Approximation approach. In view of the forthcoming experimental data, we shortly present a novel Poincare' covariant description of the nuclear target, implementing a Light-Front analysis at finite Q^2, within the Bakamijan-Thomas construction of the Poincare' generators. Furthermore, as a by-product of the introduction of a Light-Front spin-dependent spectral function for a J=1/2 system, we straightforwardly extend our analysis to the quark-quark correlator, obtaining three new exact relations between the six leading-twist Transverse-Momentum Dependent distributions., Comment: 6 pages, invited talk given by S. Scopetta at "TRANSVERSITY 2011", Third International Workshop on Transverse Polarization Phenomena in Hard Scattering Veli Losinj, Croatia, 29 August - 2 September 2011. Submitted to "Nuovo Cimento C"
- Published
- 2011
44. Variants in Human ATP Synthase Mitochondrial Genes: Biochemical Dysfunctions, Associated Diseases, and Therapies
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Del Dotto, Valentina, primary, Musiani, Francesco, additional, Baracca, Alessandra, additional, and Solaini, Giancarlo, additional
- Published
- 2024
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45. New insights into idebenone therapy in relation to NQO1
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La Morgia, Chiara, primary, Aleo, Serena Jasmine, additional, Del Dotto, Valentina, additional, Romagnoli, Martina, additional, Fiorini, Claudio, additional, Capirossi, Giada, additional, Peron, Camille, additional, Maresca, Alessandra, additional, Caporali, Leonardo, additional, Capristo, Mariantonietta, additional, Tropeano, Concetta Valentina, additional, Zanna, Claudia, additional, Ross‐Cisneros, Fred, additional, Sadun, Alfredo A., additional, Pignataro, Maria Gemma, additional, Giordano, Carla, additional, Fasano, Chiara, additional, Porcelli, Anna Maria, additional, Tioli, Gaia, additional, Musiani, Francesco, additional, Catania, Alessia, additional, Lamperti, Costanza, additional, Marzoli, Stefania Bianchi, additional, De Negri, Annamaria, additional, Cascavilla, Maria Lucia, additional, Battista, Marco, additional, Barboni, Piero, additional, Carbonelli, Michele, additional, Amore, Giulia, additional, Smirnov, Dmitrii, additional, Vasilescu, Catalina, additional, Farzeen, Aiman, additional, Blickhäuser, Beryll, additional, Prokisch, Holger, additional, Catarino, Claudia, additional, Klopstock, Thomas, additional, Tiranti, Valeria, additional, Carelli, Valerio, additional, and Ghelli, Anna Maria, additional
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- 2024
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46. Deciphering OPA1 mutations pathogenicity by combined analysis of human, mouse and yeast cell models
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Del Dotto, Valentina, Fogazza, Mario, Musiani, Francesco, Maresca, Alessandra, Aleo, Serena J., Caporali, Leonardo, La Morgia, Chiara, Nolli, Cecilia, Lodi, Tiziana, Goffrini, Paola, Chan, David, Carelli, Valerio, Rugolo, Michela, Baruffini, Enrico, and Zanna, Claudia
- Published
- 2018
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47. OPA1: How much do we know to approach therapy?
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Del Dotto, Valentina, Fogazza, Mario, Lenaers, Guy, Rugolo, Michela, Carelli, Valerio, and Zanna, Claudia
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- 2018
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48. Dominant Optic Atrophy (DOA): Modeling the Kaleidoscopic Roles of OPA1 in Mitochondrial Homeostasis
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Valentina Del Dotto and Valerio Carelli
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OPA1 mutations ,dominant optic atrophy ,OPA1 ,mitochondria ,cell models ,mouse models ,Neurology. Diseases of the nervous system ,RC346-429 - Abstract
In the year 2000, the discovery of OPA1 mutations as causative for dominant optic atrophy (DOA) was pivotal to rapidly expand the field of mitochondrial dynamics and describe the complex machinery governing this pathway, with a multitude of other genes and encoded proteins involved in neurodegenerative disorders of the optic nerve. OPA1 turned out to be a much more complex protein than initially envisaged, connecting multiple pathways beyond its strict role in mitochondrial fusion, such as sensing of OXPHOS needs and mitochondrial DNA maintenance. As a consequence, an increasing need to investigate OPA1 functions at multiple levels has imposed the development of multiple tools and models that are here reviewed. Translational mitochondrial medicine, with the ultimate objective of translating basic science necessary to understand pathogenic mechanisms into therapeutic strategies, requires disease modeling at multiple levels: from the simplest, like in yeast, to cell models, including the increasing use of reprogrammed stem cells (iPSCs) from patients, to animal models. In the present review, we thoroughly examine and provide the state of the art of all these approaches.
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- 2021
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49. Beam-based characterization of plasma density in a capillary-discharge waveguide
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S. Romeo, M. Cesarini, A. Del Dotto, M. Ferrario, M. Galletti, R. Pompili, and V. Shpakov
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Physics ,QC1-999 - Abstract
Next-generation plasma-based accelerators can push electron bunches to gigaelectronvolt energies within centimeter distances. In these devices, the accelerating force is provided by a driver pulse, either a laser pulse or a particle bunch, that loses its energy into the plasma generating huge electric fields up to tens of GV/m. The stability of such fields strongly depends on plasma density, whose exact value should be precisely known and controlled. However, currently available methods based on spectroscopic or interferometric techniques find it very difficult to measure plasma density lower than 1015–16 cm−3 in capillary-discharge waveguides. Here, we present a novel diagnostic tool that allows us to estimate the average density of a plasma capillary by probing it with an ultra-relativistic electron beam. The plasma density and the generated accelerating field are inferred by analyzing the beam longitudinal phase space after its interaction with the plasma. The results are validated by simulations showing excellent agreement.
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- 2021
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50. Eight human OPA1 isoforms, long and short: What are they for?
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Del Dotto, Valentina, Fogazza, Mario, Carelli, Valerio, Rugolo, Michela, and Zanna, Claudia
- Published
- 2018
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