1. Non-embolic outcomes in patients with cardiovascular disease and atrial fibrillation treated with rivaroxaban.
- Author
-
Marín F, Fernández MS, Barón-Esquivias G, Barrios V, Lekuona I, Pérez-Cabeza AI, Masjuan J, Del Vigo ER, Vázquez Rodríguez JM, Freixa-Pamias R, Schilling VR, Arribas F, Priu CR, and Sánchez MA
- Subjects
- Humans, Rivaroxaban therapeutic use, Prospective Studies, Factor Xa Inhibitors therapeutic use, Anticoagulants adverse effects, Atrial Fibrillation complications, Atrial Fibrillation drug therapy, Cardiovascular Diseases chemically induced, Coronary Artery Disease, Stroke chemically induced, Peripheral Arterial Disease chemically induced, Peripheral Arterial Disease epidemiology
- Abstract
Aim: It is not well known how comorbidities may change the prognosis of atrial fibrillation (AF) patients. This study was aimed to analyze the impact of cardiovascular disease on this population. Materials & methods: EMIR was a multicenter, prospective study, including 1433 AF patients taking rivaroxaban for ≥6 months. Data were analyzed according to the presence of vascular disease. Results: Coronary artery disease was detected in 16.4%, peripheral artery disease/aortic plaque in 6.7%, vascular disease in 28.3%. Patients with coronary artery disease had higher rates (per 100 patient-years) of major adverse cardiovascular events (2.98 vs 0.71; p < 0.001) and cardiovascular death (1.79 vs 0.41; p = 0.004). Those with vascular disease had higher rates of thromboembolic events (1.47 vs 0.44; p = 0.007), major adverse cardiovascular events (2.03 vs 0.70; p = 0.004), and cardiovascular death (1.24 vs 0.39; p = 0.025). Patients with peripheral artery disease/aortic plaque had similar rates. Conclusion: AF patients with vascular disease have a higher risk of non-embolic outcomes.
- Published
- 2023
- Full Text
- View/download PDF