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4. T follicular helper–like cells contribute to skin fibrosis

Author

Taylor, Devon K., Mittereder, Nanette, Kuta, Ellen, Delaney, Tracy, Burwell, Timothy, Dacosta, Karma, Zhao, Weiguang, Cheng, Lily I., Brown, Charles, Boutrin, Anmarie, Guo, Xiang, White, Wendy I., Zhu, Jie, Dong, Huifang, Bowen, Michael A., Lin, Jia, Gao, Changshou, Yu, Li, Ramaswamy, Madhu, Gaudreau, Marie-Claude, Woods, Rob, Herbst, Ronald, and Carlesso, Gianluca

Published
2018
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15. Essential Role for the C5a Receptor in Regulating the Effector Phase of Synovial Infiltration and Joint Destruction in Experimental Arthritis

Author

Grant, Ethan P., primary, Picarella, Dominic, additional, Burwell, Timothy, additional, Delaney, Tracy, additional, Croci, Alisa, additional, Avitahl, Nicole, additional, Humbles, Alison A., additional, Gutierrez-Ramos, Jose-Carlos, additional, Briskin, Michael, additional, Gerard, Craig, additional, and Coyle, Anthony J., additional

Published
2002
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21. ICOS is critical for T helper cell?mediated lung mucosal inflammatory responses.

Author

Gonzalo, Jose Angel, Tian, Jane, Delaney, Tracy, Corcoran, Justin, Rottman, James B., Lora, Jose, Al-garawi, Amal, Kroczek, Richard, Gutierrez-Ramos, Jose Carlos, and Coyle, Anthony J.

Subjects
CD antigens, T cells, IMMUNE response
Abstract

We examined the requirement for and cooperation between CD28 and inducible costimulator (ICOS) in effective T helper (TH) cell responses in vivo. We found that both CD28 and ICOS were critical in determining the outcome of an immune response; cytolytic T lymphocyte?associated antigen 4?immunoglobulin (CTLA-4?Ig), ICOS-Ig and/or a neutralizing ICOS monoclonal antibody attenuated T cell expansion, TH2 cytokine production and eosinophilic inflammation. CD28-dependent signaling was essential during priming, whereas ICOS?B7RP-1 regulated TH effector responses, and the up-regulation of chemokine receptors that determine T cell migration. Our data suggests a scenario whereby both molecules regulate the outcome of the immune response but play separate key roles: CD28 primes T cells and ICOS regulates effector responses. [ABSTRACT FROM AUTHOR]

Published
2001
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22. Blocking inducible co‐stimulator in the absence of CD28 impairs Th1 and CD25+ regulatory T cells in murine colitis

Author

Jong, Ype P. de, Rietdijk, Svend T., Faubion, William A., Abadia‐Molina, Ana C., Clarke, Kareem, Mizoguchi, Emiko, Tian, Jane, Delaney, Tracy, Manning, Stephen, Gutierrez‐Ramos, Jose‐Carlos, Bhan, Atul K., Coyle, Anthony J., and Terhorst, Cox

Abstract

Several autoimmune disease models depend on an imbalance in the activation of aggressor Th1 and CD4+CD25+ regulatory T (Treg) cells. Here we compare the requirement for signals through the co‐stimulatory molecules CD28 and inducible co‐stimulator (ICOS) in chronic murine colitis, a model for inflammatory bowel disease. We used a colitis model in which disease‐causing CD45RBhi T cells alone or in combination with CD4+CD25+ T cells from either CD28‐deficient or wild‐type donors were transferred into T cell‐deficient animals, half of which were treated with ICOS‐blocking reagents. Blocking ICOS on the surface of CD28‐deficient Th1 cells abrogated development of colitis, whereas blocking CD28 or ICOS alone had little to no effect on disease induction. In contrast to Th1 cells, regulatory T cell functioning depended mostly on CD28 signaling with only a minor contribution for ICOS. We conclude that CD28 and ICOS collaborate to development of murine colitis by aggressor Th1 cells, and that CD28 is required for Treg cells, which should caution against the use of CD28‐blocking reagents in inflammatory bowel disease.

Published
2004
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23. Analytical results and sample locality map of stream-sediment, heavy-mineral-concentrate, and rock samples from the East Fork High Rock Canyon (CA-020-914/NV-020-006), Little High Rock Canyon (CA-020-913/NV-020-008), and High Rock Canyon (CA-020-913B) Wilderness Study Areas, Humboldt and Washoe Counties, Nevada

Author

Adrian, Betty M., primary, Turner, R. L., additional, Fey, D. C., additional, Malcolm, Mollie, additional, Gent, C. A., additional, and Delaney, Tracy, additional

Published
1988
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24. Extend the eviction moratorium to ward off another public health crisis.

Author

Delaney, Tracy and Triunfo-Cortez, Zenei

Subjects
EVICTION, PUBLIC health, CRISES
Abstract

The article offers information on the public health impacts of the Covid-19 pandemic in the California, U.S.; along with mentions the positive effect of extending the moratorium across the California.

Published
2021

25. Assessment of the Nutrition and Physical Activity Education Needs of Child Care Providers Across Nebraska

Author

Delaney, Tracy C

Subjects
Dietetics and Clinical Nutrition, Pre-Elementary, Early Childhood, Kindergarten Teacher Education
Abstract

Studies estimate 82% of children less than six years of age in the United States are enrolled in non-parental care outside of their home (1). In Nebraska 4,106 child care providers hold licensure (2). This unique child care environment offers opportunity to address food related challenges facing young children. The purpose of this study is to assess the nutrition and physical activity practices provided for children, self-efficacy, and perceived needs of child care providers across Nebraska. A gap in knowledge exist for practices of child care providers in Nebraska and the impact of Child and Adult Care Food Program (CACFP), Nutrition and Physical Activity Self-Assessment for Child Care (NAP SACC), and I Am Moving, I Am Learning (IMIL) on nutrition and physical activity practices provided to children in Nebraska child care. Participants included a stratified random sample of 1,000 licensed child care providers across Nebraska. A mail survey was sent to the sample of providers. Data was analyzed using SPSS Version 21. The preferred methods of training included use of video, computer module training, and book curriculum. Topics most preferred by providers included introducing foods to picky eaters, preventing food waste, and physical activity planning. Statistical differences were observed between child care centers and home care participants, CACFP and non CACFP participants, NAP SACC and non NAP SACC participants, and IMIL and non IMIL Participants. Many participants are meeting recommended guidelines. Nutrition education, nutrition policy, milk offered for children 12 to 24 months, physical activity policy, and physical activity education were found to be areas for improvement. Utilizing nutrition and physical activity programs may assist child care providers in improving nutrition and physical activity behaviors in children and families. In order to impact Nebraska children more comprehensive regulations at a state level may need to be considered. A variety of training methods should be available to best accommodate the needs of all providers in Nebraska. Advisor: Julie Ann Albrecht

Published
2013

26. Behavioral health issue brief: mental health and substance abuse parity: year end report-2002.

Author

Delaney T and Crean E

Subjects
Humans, Insurance, Health legislation & jurisprudence, Mental Disorders therapy, Mental Health Services legislation & jurisprudence, State Government, Substance-Related Disorders economics, Substance-Related Disorders therapy, United States, Insurance Coverage legislation & jurisprudence, Insurance, Health economics, Mental Disorders economics, Mental Health Services economics
Abstract

Parity benefits for mental health continue to be on the agenda of many state legislatures. A broad spectrum of opinions surround what mental health parity could and should be. There are strong proponents that advocate for nothing less than full parity for mental health and substance abuse treatment; equally strong are the groups that oppose parity because they believe it will lead to a health care cost increase and, therefore, an increase in the number of uninsured. Both sides continue to make progress as the victories and the defeats unfold on the floors of state legislatures.

Published
2002

27. Behavioral health issue brief: minimum mandated benefits and mandated offerings for mental health and substance abuse: year end report-2002.

Author

Delaney T and Crean E

Subjects
Humans, Insurance Coverage, Insurance, Psychiatric legislation & jurisprudence, Medically Uninsured, Mental Disorders therapy, Mental Health Services legislation & jurisprudence, State Government, Substance-Related Disorders therapy, United States, Insurance, Psychiatric economics, Mental Disorders economics, Mental Health Services economics, Substance-Related Disorders economics
Abstract

Benefit mandates require that some service be provided. Mental health and substance abuse treatment mandates are two of the many types of benefit mandates in state law. The debate over mandated benefit legislation typically centers around consumer protection versus cost. Proponents contend that mandates are necessary to ensure adequate health care for consumers. However, opponents generally argue that mandates drive up premiums, which contributes to the growing number of uninsured.

Published
2002

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