44 results on '"Delarue, Marion"'
Search Results
2. Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in Age-Well
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André, Claire, Champetier, Pierre, Chauveau, Léa, Collette, Fabienne, Dautricourt, Sophie, de Flores, Robin, De La Sayette, Vincent, Demnitz-King, Harriet, Fauvel, Séverine, Felisatti, Francesca, Ferment, Victor, Ferrand-Devouge, Eglantine, Gonneaud, Julie, Garnier-Crussard, Antoine, Hamel, Anaïs, Haudry, Sacha, Krolak-Salmon, Pierre, Kuhn, Elizabeth, Lefranc, Valérie, Lutz, Antoine, Ourry, Valentin, Palix, Cassandre, Quillard, Anne, Rauchs, Géraldine, Salmon, Eric, Touron, Edelweiss, Vuilleumier, Patrik, Whitfield, Tim, Liebscher, Maxie, White, Silke, Hass, Simon, Chocat, Anne, Mezenge, Florence, Landeau, Brigitte, Delarue, Marion, Hébert, Oriane, Turpin, Anne-Laure, Marchant, Natalie L., Chételat, Gaël, Klimecki, Olga, Poisnel, Géraldine, and Wirth, Miranka
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- 2025
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3. Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial
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André, Claire, Lugo, Sebastian Baez, Batchelor, Martine, Beaugonin, Axel, Champetier, Pierre, Chauveau, Léa, Chételat, Gael, Chocat, Anne, Collette, Fabienne, De Florès, Robin, de La Sayette, Vincent, Delarue, Marion, Fauvel, Séverine, Felisatti, Francesca, Devouge, Eglantine Ferrand, Frison, Eric, Gonneaud, Julie, Tran, Thien Huong, Kaliman, Perla, Klimecki, Olga, Kuhn, Elizabeth, Landeau, Brigitte, Lefranc, Valérie, Lehodey, Asrar, Lutz, Antoine, Marchant, Natalie, Mezenge, Florence, Ourry, Valentin, Palix, Cassandre, Poisnel, Géraldine, Quillard, Anne, Rauchs, Géraldine, Salmon, Eric, Schimmer, Corinne, Touron, Edelweiss, Turpin, Anne-Laure, Vuilleumier, Patrik, Álvarez-López, María Jesús, Fernández, Daniel, Schlosser, Marco, Vivien, Denis, and Marchant, Natalie L.
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- 2025
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4. Atypical Brain Aging and Its Association With Working Memory Performance in Major Depressive Disorder
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Adamson, Chris, Adler, Sophie, Alexander-Bloch, Aaron F., Anagnostou, Evdokia, Anderson, Kevin M., Areces-Gonzalez, Ariosky, Astle, Duncan E., Auyeung, Bonnie, Ayub, Muhammad, Bae, Jong Bin, Ball, Gareth, Baron-Cohen, Simon, Beare, Richard, Bedford, Saashi A., Benegal, Vivek, Bethlehem, Richard A.I., Beyer, Frauke, Blangero, John, Cábez, Manuel Blesa, Boardman, James P., Borzage, Matthew, Bosch-Bayard, Jorge F., Bourke, Niall, Bullmore, Edward T., Calhoun, Vince D., Chakravarty, Mallar M., Chen, Christina, Chertavian, Casey, Chetelat, Gaël, Chong, Yap S., Corvin, Aiden, Costantino, Manuela, Courchesne, Eric, Crivello, Fabrice, Cropley, Vanessa L., Crosbie, Jennifer, Crossley, Nicolas, Delarue, Marion, Delorme, Richard, Desrivieres, Sylvane, Devenyi, Gabriel, Di Biase, Maria A., Dolan, Ray, Donald, Kirsten A., Donohoe, Gary, Dorfschmidt, Lena, Dunlop, Katharine, Edwards, Anthony D., Elison, Jed T., Ellis, Cameron T., Elman, Jeremy A., Eyler, Lisa, Fair, Damien A., Fletcher, Paul C., Fonagy, Peter, Franz, Carol E., Galan-Garcia, Lidice, Gholipour, Ali, Giedd, Jay, Gilmore, John H., Glahn, David C., Goodyer, Ian M., Grant, P.E., Groenewold, Nynke A., Gudapati, Shreya, Gunning, Faith M., Gur, Raquel E., Gur, Ruben C., Hammill, Christopher F., Hansson, Oskar, Hedden, Trey, Heinz, Andreas, Henson, Richard N., Heuer, Katja, Hoare, Jacqueline, Holla, Bharath, Holmes, Avram J., Huang, Hao, Ipser, Jonathan, Jack, Clifford R., Jr., Jackowski, Andrea P., Jia, Tianye, Jones, David T., Jones, Peter B., Kahn, Rene S., Karlsson, Hasse, Karlsson, Linnea, Kawashima, Ryuta, Kelley, Elizabeth A., Kern, Silke, Kim, Ki-Woong, Kitzbichler, Manfred G., Kremen, William S., Lalonde, François, Landeau, Brigitte, Lerch, Jason, Lewis, John D., Li, Jiao, Liao, Wei, Liston, Conor, Lombardo, Michael V., Lv, Jinglei, Mallard, Travis T., Marcelis, Machteld, Mathias, Samuel R., Mazoyer, Bernard, McGuire, Philip, Meaney, Michael J., Mechelli, Andrea, Misic, Bratislav, Morgan, Sarah E., Mothersill, David, Ortinau, Cynthia, Ossenkoppele, Rik, Ouyang, Minhui, Palaniyappan, Lena, Paly, Leo, Pan, Pedro M., Pantelis, Christos, Park, Min Tae M., Paus, Tomas, Pausova, Zdenka, Paz-Linares, Deirel, Binette, Alexa Pichet, Pierce, Karen, Qian, Xing, Qiu, Anqi, Raznahan, Armin, Rittman, Timothy, Rodrigue, Amanda, Rollins, Caitlin K., Romero-Garcia, Rafael, Ronan, Lisa, Rosenberg, Monica D., Rowitch, David H., Salum, Giovanni A., Satterthwaite, Theodore D., Schaare, H. Lina, Schabdach, Jenna, Schachar, Russell J., Schöll, Michael, Schultz, Aaron P., Seidlitz, Jakob, Sharp, David, Shinohara, Russell T., Skoog, Ingmar, Smyser, Christopher D., Sperling, Reisa A., Stein, Dan J., Stolicyn, Aleks, Suckling, John, Sullivan, Gemma, Thyreau, Benjamin, Toro, Roberto, Traut, Nicolas, Tsvetanov, Kamen A., Turk-Browne, Nicholas B., Tuulari, Jetro J., Tzourio, Christophe, Vachon-Presseau, Étienne, Valdes-Sosa, Mitchell J., Valdes-Sosa, Pedro A., Valk, Sofie L., van Amelsvoort, Therese, Vandekar, Simon N., Vasung, Lana, Vértes, Petra E., Victoria, Lindsay W., Villeneuve, Sylvia, Villringer, Arno, Vogel, Jacob W., Wagstyl, Konrad, Wang, Yin-Shan S., Warfield, Simon K., Warrier, Varun, Westman, Eric, Westwater, Margaret L., Whalley, Heather C., White, Simon R., Witte, A. Veronica, Yang, Ning, Yeo, B.T. Thomas, Yun, Hyuk Jin, Zalesky, Andrew, Zar, Heather J., Zettergren, Anna, Zhou, Juan H., Ziauddeen, Hisham, Zimmerman, Dabriel, Zugman, Andre, Zuo, Xi-Nian N., Ho, Natalie C.W., Nogovitsyn, Nikita, Metzak, Paul, Ballester, Pedro L., Hassel, Stefanie, Rotzinger, Susan, Poppenk, Jordan, Lam, Raymond W., Taylor, Valerie H., Milev, Roumen, Frey, Benicio N., Harkness, Kate L., Addington, Jean, and Kennedy, Sidney H.
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- 2024
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5. Relationships between diabetes-related vascular risk factors and neurodegeneration biomarkers in healthy aging and Alzheimer's disease
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Palix, Cassandre, Felisatti, Francesca, Gonneaud, Julie, Kuhn, Elizabeth, Mézenge, Florence, Landeau, Brigitte, Chocat, Anne, Quillard, Anne, Egret, Stéphanie, Delarue, Marion, Sayette, Vincent De La, Vivien, Denis, Chételat, Gaël, and Poisnel, Géraldine
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- 2022
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6. The evolution of subjective cognition after meditation training in older people: a secondary analysis of the three-arm age-well randomized controlled trial.
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Requier, Florence, Demnitz-King, Harriet, Frison, Eric, Delarue, Marion, Gonneaud, Julie, Chételat, Gaël, Klimecki, Olga, Salmon, Eric, Lutz, Antoine, Marchant, Natalie L., and Collette, Fabienne
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MNEMONICS ,OLDER people ,COGNITIVE ability ,COGNITIVE training ,COGNITIVE aging - Abstract
Aging is associated with cognitive changes, even in the absence of brain pathology. This study aimed to determine if meditation training, by comparison to active and passive control groups, is linked to changes in the perception of cognitive functioning in older adults. One hundred thirty-four healthy older participants from the Age-Well Randomized Clinical Trial were included: 45 followed a meditation training, 45 a non-native language training and 44 had no intervention. Subjective cognition was assessed at baseline and following the 18-month intervention period. Perception of attentional efficiency was assessed using internal and external Attentional Style Questionnaire (ASQ) subscale scores. Perception of global cognitive capacities was measured via the total score of Cognitive Difficulties Scale (CDS). Deltas ([posttest minus pretest scores]/standard deviation at pretest) were calculated for the analyses. Generalized mixed effects models controlling for age, sex, education and baseline scores revealed that meditation training decreased the vulnerability score toward external distractors measured by the ASQ compared to non-native language training. However, no between-groups differences on ASQ internal or CDS total scores were observed. Results suggest a beneficial effect of meditation practice on perceived management of external distracting information in daily life. Meditation training may cultivate the ability to focus on specific information (e.g., breath) and ignore stimulation from other kinds of stimuli (e.g., noise). [ABSTRACT FROM AUTHOR]
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- 2025
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7. Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial
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Whitfield, Tim, Demnitz-King, Harriet, Schlosser, Marco, Barnhofer, Thorsten, Frison, Eric, Coll-Padros, Nina, Dautricourt, Sophie, Requier, Florence, Delarue, Marion, Gonneaud, Julie, Klimecki, Olga M., Lutz, Antoine, Paly, Léo, Salmon, Eric, Schild, Ann-Katrin, Walker, Zuzana, Jessen, Frank, Chételat, Gaël, Collette, Fabienne, Wirth, Miranka, and Marchant, Natalie L.
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- 2022
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8. Atypical brain aging and its association with working memory performance in major depressive disorder
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Ho, Natalie C.W., primary, Bethlehem, Richard AI., additional, Seidlitz, Jakob, additional, Nogovitsyn, Nikita, additional, Metzak, Paul, additional, Ballester, Pedro L., additional, Hassel, Stefanie, additional, Rotzinger, Susan, additional, Poppenk, Jordan, additional, Lam, Raymond W., additional, Taylor, Valerie H., additional, Milev, Roumen, additional, Adamson, Chris, additional, Adler, Sophie, additional, Alexander-Bloch, Aaron F., additional, Anagnostou, Evdokia, additional, Anderson, Kevin M., additional, Areces-Gonzalez, Ariosky, additional, Astle, Duncan E., additional, Auyeung, Bonnie, additional, Ayub, Muhammad, additional, Bae, Jong Bin, additional, Ball, Gareth, additional, Baron-Cohen, Simon, additional, Beare, Richard, additional, Bedford, Saashi A., additional, Benegal, Vivek, additional, Bethlehem, Richard A.I., additional, Beyer, Frauke, additional, Blangero, John, additional, Blesa Cábez, Manuel, additional, Boardman, James P., additional, Borzage, Matthew, additional, Bosch-Bayard, Jorge F., additional, Bourke, Niall, additional, Bullmore, Edward T., additional, Calhoun, Vince D., additional, Chakravarty, Mallar M., additional, Chen, Christina, additional, Chertavian, Casey, additional, Chetelat, Gaël, additional, Chong, Yap S., additional, Corvin, Aiden, additional, Costantino, Manuela, additional, Courchesne, Eric, additional, Crivello, Fabrice, additional, Cropley, Vanessa L., additional, Crosbie, Jennifer, additional, Crossley, Nicolas, additional, Delarue, Marion, additional, Delorme, Richard, additional, Desrivieres, Sylvane, additional, Devenyi, Gabriel, additional, Di Biase, Maria A., additional, Dolan, Ray, additional, Donald, Kirsten A., additional, Donohoe, Gary, additional, Dorfschmidt, Lena, additional, Dunlop, Katharine, additional, Edwards, Anthony D., additional, Elison, Jed T., additional, Ellis, Cameron T., additional, Elman, Jeremy A., additional, Eyler, Lisa, additional, Fair, Damien A., additional, Fletcher, Paul C., additional, Fonagy, Peter, additional, Franz, Carol E., additional, Galan-Garcia, Lidice, additional, Gholipour, Ali, additional, Giedd, Jay, additional, Gilmore, John H., additional, Glahn, David C., additional, Goodyer, Ian M., additional, Grant, P.E., additional, Groenewold, Nynke A., additional, Gudapati, Shreya, additional, Gunning, Faith M., additional, Gur, Raquel E., additional, Gur, Ruben C., additional, Hammill, Christopher F., additional, Hansson, Oskar, additional, Hedden, Trey, additional, Heinz, Andreas, additional, Henson, Richard N., additional, Heuer, Katja, additional, Hoare, Jacqueline, additional, Holla, Bharath, additional, Holmes, Avram J., additional, Huang, Hao, additional, Ipser, Jonathan, additional, Jack, Clifford R., additional, Jackowski, Andrea P., additional, Jia, Tianye, additional, Jones, David T., additional, Jones, Peter B., additional, Kahn, Rene S., additional, Karlsson, Hasse, additional, Karlsson, Linnea, additional, Kawashima, Ryuta, additional, Kelley, Elizabeth A., additional, Kern, Silke, additional, Kim, Ki-Woong, additional, Kitzbichler, Manfred G., additional, Kremen, William S., additional, Lalonde, François, additional, Landeau, Brigitte, additional, Lerch, Jason, additional, Lewis, John D., additional, Li, Jiao, additional, Liao, Wei, additional, Liston, Conor, additional, Lombardo, Michael V., additional, Lv, Jinglei, additional, Mallard, Travis T., additional, Marcelis, Machteld, additional, Mathias, Samuel R., additional, Mazoyer, Bernard, additional, McGuire, Philip, additional, Meaney, Michael J., additional, Mechelli, Andrea, additional, Misic, Bratislav, additional, Morgan, Sarah E., additional, Mothersill, David, additional, Ortinau, Cynthia, additional, Ossenkoppele, Rik, additional, Ouyang, Minhui, additional, Palaniyappan, Lena, additional, Paly, Leo, additional, Pan, Pedro M., additional, Pantelis, Christos, additional, Park, Min Tae M., additional, Paus, Tomas, additional, Pausova, Zdenka, additional, Paz-Linares, Deirel, additional, Pichet Binette, Alexa, additional, Pierce, Karen, additional, Qian, Xing, additional, Qiu, Anqi, additional, Raznahan, Armin, additional, Rittman, Timothy, additional, Rodrigue, Amanda, additional, Rollins, Caitlin K., additional, Romero-Garcia, Rafael, additional, Ronan, Lisa, additional, Rosenberg, Monica D., additional, Rowitch, David H., additional, Salum, Giovanni A., additional, Satterthwaite, Theodore D., additional, Schaare, H. Lina, additional, Schabdach, Jenna, additional, Schachar, Russell J., additional, Schöll, Michael, additional, Schultz, Aaron P., additional, Sharp, David, additional, Shinohara, Russell T., additional, Skoog, Ingmar, additional, Smyser, Christopher D., additional, Sperling, Reisa A., additional, Stein, Dan J., additional, Stolicyn, Aleks, additional, Suckling, John, additional, Sullivan, Gemma, additional, Thyreau, Benjamin, additional, Toro, Roberto, additional, Traut, Nicolas, additional, Tsvetanov, Kamen A., additional, Turk-Browne, Nicholas B., additional, Tuulari, Jetro J., additional, Tzourio, Christophe, additional, Vachon-Presseau, Étienne, additional, Valdes-Sosa, Mitchell J., additional, Valdes-Sosa, Pedro A., additional, Valk, Sofie L., additional, van Amelsvoort, Therese, additional, Vandekar, Simon N., additional, Vasung, Lana, additional, Vértes, Petra E., additional, Victoria, Lindsay W., additional, Villeneuve, Sylvia, additional, Villringer, Arno, additional, Vogel, Jacob W., additional, Wagstyl, Konrad, additional, Wang, Yin-Shan S., additional, Warfield, Simon K., additional, Warrier, Varun, additional, Westman, Eric, additional, Westwater, Margaret L., additional, Whalley, Heather C., additional, White, Simon R., additional, Witte, A. Veronica, additional, Yang, Ning, additional, Yeo, B.T. Thomas, additional, Yun, Hyuk Jin, additional, Zalesky, Andrew, additional, Zar, Heather J., additional, Zettergren, Anna, additional, Zhou, Juan H., additional, Ziauddeen, Hisham, additional, Zimmerman, Dabriel, additional, Zugman, Andre, additional, Zuo, Xi-Nian N., additional, Frey, Benicio N., additional, Harkness, Kate L., additional, Addington, Jean, additional, and Kennedy, Sidney H., additional
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- 2024
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9. Increased medial temporal lobe functional connectivity is critical in Alzheimer’s disease: evidences from longitudinal analyses across the whole cognitive continuum
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Chauveau, Léa, primary, Landeau, Brigitte, additional, Dautricourt, Sophie, additional, Delarue, Marion, additional, Hébert, Oriane, additional, la Sayette, Vincent De, additional, Chetelat, Gael, additional, and de Flores, Robin, additional
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- 2023
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10. Medial temporal lobe hyperconnectivity is key to Alzheimer's disease: Insight from physiological aging to dementia
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Chauveau, Léa, primary, Landeau, Brigitte, additional, Dautricourt, Sophie, additional, Turpin, Anne-Laure, additional, Delarue, Marion, additional, Hébert, Oriane, additional, de La Sayette, Vincent, additional, Chételat, Gaël, additional, and de Flores, Robin, additional
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- 2023
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11. White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition
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Garnier-Crussard, Antoine, Bougacha, Salma, Wirth, Miranka, André, Claire, Delarue, Marion, Landeau, Brigitte, Mézenge, Florence, Kuhn, Elizabeth, Gonneaud, Julie, Chocat, Anne, Quillard, Anne, Ferrand-Devouge, Eglantine, de La Sayette, Vincent, Vivien, Denis, Krolak-Salmon, Pierre, and Chételat, Gaël
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- 2020
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12. Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.
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Ourry, Valentin, Réhel, Stéphane, Andre, C., Mary, Alison, Paly, Léo, Delarue, Marion, Requier, Florence, Hendy, Adam, Collette, Fabienne, Marchant, Natalie NL, Felisatti, Francesca, Palix, Cassandre, Vivien, Denis, De la Sayette, Vincent, Chételat, Gaël, Gonneaud, Julie, Rauchs, Géraldine, Medit-Ageing Research Group, Ourry, Valentin, Réhel, Stéphane, Andre, C., Mary, Alison, Paly, Léo, Delarue, Marion, Requier, Florence, Hendy, Adam, Collette, Fabienne, Marchant, Natalie NL, Felisatti, Francesca, Palix, Cassandre, Vivien, Denis, De la Sayette, Vincent, Chételat, Gaël, Gonneaud, Julie, Rauchs, Géraldine, and Medit-Ageing Research Group
- Abstract
Sleep, especially slow wave sleep (SWS), is essential for cognitive functioning and is reduced in aging. The impact of sleep quality on cognition is variable, especially in aging. Cognitive reserve (CR) may be an important modulator of these effects. We aimed at investigating this question to better identify individuals in whom sleep disturbances might have greater behavioral consequences. Polysomnography and neuropsychological assessments were performed in 135 cognitively intact older adults (mean age ± SD: 69.4 ± 3.8y) from the Age-Well randomized controlled trial (baseline data). Two measures of cognitive engagement throughout life were used as CR proxies. Linear regression analyses were performed between the proportion of SWS, and executive function and episodic memory composite scores. Then, interaction analyses between SWS and CR proxies on cognition were conducted to assess the possible impact of CR on these links. SWS was positively associated with episodic memory, but not with executive function. CR proxies modulated the associations between SWS and both executive and episodic memory performance. Specifically, individuals with higher CR were able to maintain cognitive performance despite low amounts of SWS. This study provides the first evidence that CR may protect against the deleterious effects of age-related sleep changes on cognition., info:eu-repo/semantics/published
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- 2023
13. Interaction between APOE4 and lifestyle on neuroimaging biomarkers and cognition in cognitively unimpaired older adults
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Felisatti, Francesca, primary, Chauveau, Léa, additional, de Flores, Robin, additional, Marchant, Natalie L, additional, Collette, Fabienne, additional, Demnitz‐King, Harriet, additional, Whitfield, Tim, additional, Requier, Florence, additional, Palix, Cassandre, additional, Haudry, Sacha, additional, Delarue, Marion, additional, la Sayette, Vincent De, additional, Vivien, Denis, additional, Poisnel, Géraldine, additional, Chetelat, Gael, additional, and Gonneaud, Julie, additional
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- 2023
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14. Effects of Meditation Training and Non-Native Language Training on Cognition in Older Adults: A Secondary Analysis of a Randomized Clinical Trial
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Demnitz-King, Harriet, Requier, Florence, Klimecki-Lenz, Olga Maria, Paly, Léo, Salmon, Eric, Schild, Ann-Katrin, Wirth, Miranka, Frison, Eric, Lutz, Antoine, Chételat, Gaël, Collette, Fabienne, Marchant, Natalie L, Whitfield, Tim, Group, Medit-Ageing Research, Schlosser, Marco, Gonneaud, Julie, Ware, Caitlin, Barnhofer, Thorsten, Coll-Padros, Nina, Dautricourt, Sophie, Delarue, Marion, Allais, Florence, André, Claire, Arenaza-Urquijo, Eider, Asselineau, Julien, Baez Lugo, Sebastian, Batchelor, Martine, Beaugonin, Axel, Bejanin, Alexandre, Botton, Maelle, Champetier, Pierre, Chocat, Anne, De Flores, Robin, De La Sayette, Vincent, Delamilleure, Pascal, Egret, Stéphanie, Espérou, Hélene, Felisatti, Francesca, Ferrand-Devouges, Eglantine, Garnier-Groussard, Antoine, Gheysen, Francis, Heidmann, Marc, Hendy, Anne, Huong Tran, Thien, Joret Philippe, Agathe, Kuhn, Elizabeth, Landeau, Brigitte, Le Du, Gwendoline, Lefranc, Valérie, Mezenge, Florence, Moulinet, Inés, Ourry, Valentin, Palix, Cassandre, Quillard, Anne, Rauchs, Géraldine, Rehel, Stéphane, Schwimmer, Corrine, Sherif, Siya, Tomadesso, Clémence, Touron, Edelweiss, and Vanhoutte, Matthieu
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ddc:610 - Abstract
Nonpharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults.To investigate the effects of 18 months' meditation training and 18 months' non-native language training on cognition in older adults.This study was a secondary analysis of the Age-Well trial, an 18-month, observer-masked, randomized clinical trial with 3 parallel arms. Eligible participants were community-dwelling adults aged 65 years and older residing in Caen, France. Participants were enrolled from November 24, 2016, to March 5, 2018, and randomly assigned (1:1:1) to meditation training, non-native language (English) training, or no intervention arms. Final follow-up was completed on February 6, 2020. Data were analyzed between December 2021 and November 2022.The 18-month meditation and non-native language training interventions were structurally equivalent and included 2-hour weekly group sessions, daily home practice of 20 minutes or longer, and 1 day of more intensive home practice. The no intervention group was instructed not to change their habits and to continue living as usual.Cognition (a prespecified secondary outcome of the Age-Well trial) was assessed preintervention and postintervention via the Preclinical Alzheimer Cognitive Composite 5 (PACC5), and composites assessing episodic memory, executive function, and attention.Among 137 randomized participants, 2 were excluded for not meeting eligibility criteria, leaving 135 (mean [SD] age, 69.3 [3.8] years; 83 female [61%]) eligible for analysis. One participant among the remaining 135 did not complete the trial. In adjusted mixed effects models, no interaction effects were observed between visit and group for PACC5 (F2,131.39 = 2.58; P = .08), episodic memory (F2,131.60 = 2.34; P = .10), executive function (F2,131.26 = 0.89; P = .41), or attention (F2,131.20 = 0.34; P = .79). Results remained substantively unchanged across sensitivity and exploratory analyses.In this secondary analysis of an 18-month randomized trial, meditation and non-native language training did not confer salutary cognitive effects. Although further analyses are needed to explore the effects of these interventions on other relevant outcomes related to aging and well-being, these findings did not support the use of these interventions for enhancing cognition in cognitively healthy older adults.ClinicalTrials.gov Identifier: NCT02977819.
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- 2023
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15. Effects of meditation training and non‐native language training on cognition in older‐adults: A secondary analysis of the three‐arm Age‐Well randomized controlled trial.
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Demnitz‐King, Harriet, Requier, Florence, Whitfield, Tim, Schlosser, Marco, Gonneaud, Julie, Ware, Caitlin, Barnhofer, Thorsten, Coll‐Padros, Nina, Dautricourt, Sophie, Delarue, Marion, Klimecki, Olga M, Paly, Léo, Salmon, Eric, Schild, Ann‐Katrin, Wirth, Miranka, Frison, Eric, Lutz, Antoine, Chetelat, Gael, Collette, Fabienne, and Marchant, Natalie L
- Abstract
Background: Non‐pharmacological interventions are a potential strategy to maintain or promote cognitive functioning in older adults. We investigated the effects of 18‐months meditation or non‐native language training versus no intervention on cognition in older adults. Method: Age‐Well was an observer‐blind, randomised, controlled clinical trial with three parallel arms. Cognitively healthy adults aged ≥ 65 years and were recruited in France. Participants were randomised (1:1:1) to a meditation training, non‐native language (English) training, or a no intervention group for 18 months. Cognition (a pre‐specified secondary outcome) was assessed pre‐ and post‐intervention via the Preclinical Alzheimer's Cognitive Composite 5 (PACC5), and composites assessing episodic memory, executive function, and attention. Linear mixed models, adjusted for age, sex, and education, evaluated cognitive changes between arms. Baseline neocortical amyloid deposition was added as a fixed effect in a sensitivity analysis. Additional sensitivity analyses assessed intervention effects for participants who attended at least 20% of intervention classes or were classified as 'responders'. Results: 137 participants were randomly assigned to meditation training (n = 45), non‐native language training (n = 46), or no intervention (n = 46). Two participants were excluded for not meeting eligibility criteria, and one died during follow‐up (Figure 1). A positive effect of non‐native language training was observed on episodic memory relative to the no intervention group (0·32 [95% CI: 0·04‐0·61], p = 0·025), and on PACC5 scores compared to meditation training (0·33 [95% CI: 0·01‐0·66], p = 0·045; Figure 2). In sensitivity analyses, neither the inclusion of amyloid as an additional covariate nor the exclusion of participants who attended <20% of intervention classes affected results. Following exclusion of 'non‐responders', evidence for beneficial effects (relative to the no intervention group) on episodic memory became significant for meditation training (0·33 [0·01, 0·66]), and was weakened for non‐native language training (0·30 [‐0·02, 0·62]). No other between‐group differences emerged. Conclusion: Among cognitively healthy older adults, there was limited evidence for positive effects of 18‐months meditation training on cognition. However, in addition to having real‐life utility, non‐native language learning in late life may have beneficial effects on cognitive domains affected early in Alzheimer's disease. Studies investigating whether these effects are long‐lasting are warranted. [ABSTRACT FROM AUTHOR]
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- 2023
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16. Interaction between APOE4 and lifestyle on neuroimaging biomarkers and cognition in cognitively unimpaired older adults
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Felisatti, Francesca, primary, Chauveau, Léa, additional, de Flores, Robin, additional, Marchant, Natalie L, additional, Collette, Fabienne, additional, Demnitz‐King, Harriet, additional, Whitfield, Tim, additional, Requier, Florence, additional, Palix, Cassandre, additional, Haudry, Sacha, additional, Delarue, Marion, additional, la Sayette, Vincent De, additional, Vivien, Denis, additional, Poisnel, Géraldine, additional, Chetelat, Gael, additional, and Gonneaud, Julie, additional
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- 2022
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17. Characteristics of subjective cognitive decline associated with amyloid positivity
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Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J.B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleó, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chételat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael T., Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort‐Merino, Adrià, Binette, Alexa Pichet, Poirier, Judes, Rosa‐Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sánchez‐Saudinós, M. Belén, Ebenau, Jarith, Pocnet, Cornelia, Eckerström, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund‐Levi, Yvonne, Wallin, Åsa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty M., Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, Visser, Pieter Jelle, Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J.B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleó, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chételat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael T., Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort‐Merino, Adrià, Binette, Alexa Pichet, Poirier, Judes, Rosa‐Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sánchez‐Saudinós, M. Belén, Ebenau, Jarith, Pocnet, Cornelia, Eckerström, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund‐Levi, Yvonne, Wallin, Åsa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty M., Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, and Visser, Pieter Jelle
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- 2022
18. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
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Jansen, Willemijn J., Janssen, Olin, Tijms, Betty M., Vos, Stephanie J.B., Ossenkoppele, Rik, Visser, Pieter Jelle, Aarsland, Dag, Alcolea, Daniel, Altomare, Daniele, Von Arnim, Christine, Baiardi, Simone, Baldeiras, Ines, Barthel, Henryk, Bateman, Randall J., Van Berckel, Bart, Binette, Alexa Pichet, Blennow, Kaj, Boada, Merce, Boecker, Henning, Bottlaender, Michel, Den Braber, Anouk, Brooks, David J., Van Buchem, Mark A., Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Cohen, Ann D., Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L., Engelborghs, Sebastiaan, Epelbaum, Stéphane, Fagan, Anne M., Fan, Yong, Fladby, Tormod, Fleisher, Adam S., Van Der Flier, Wiesje M., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Frisoni, Giovanni B., Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G., Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael T., Herukka, Sanna Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Huang, Chin Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J., Jessen, Frank, Johannsen, Peter, Johnson, Keith A., Kandimalla, Ramesh, Kapaki, Elisabeth N., Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E., Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G., Kuo, Hung Chou, Van Laere, Koen, Landau, Susan M., Landeau, Brigitte, Lee, Dong Young, De Leon, Mony, Leyton, Cristian E., Lin, Kun Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Marquié, Marta, Martinez-Lage, Pablo, Maserejian, Nancy, Mattsson, Niklas, De Mendonça, Alexandre, Meyer, Philipp T., Miller, Bruce L., Minatani, Shinobu, Mintun, Mark A., Mok, Vincent C.T., Molinuevo, Jose Luis, Morbelli, Silvia Daniela, Morris, John C., Mroczko, Barbara, Na, Duk L., Newberg, Andrew, Nobili, Flavio, Nordberg, Agneta, Olde Rikkert, Marcel G.M., De Oliveira, Catarina Resende, Olivieri, Pauline, Orellana, Adela, Paraskevas, George, Parchi, Piero, Pardini, Matteo, Parnetti, Lucilla, Peters, Oliver, Poirier, Judes, Popp, Julius, Prabhakar, Sudesh, Rabinovici, Gil D., Ramakers, Inez H., Rami, Lorena, Reiman, Eric M., Rinne, Juha O., Rodrigue, Karen M., Rodríguez-Rodriguez, Eloy, Roe, Catherine M., Rosa-Neto, Pedro, Rosen, Howard J., Rot, Uros, Rowe, Christopher C., Rüther, Eckart, Ruiz, Agustín, Sabri, Osama, Sakhardande, Jayant, Sánchez-Juan, Pascual, Sando, Sigrid Botne, Santana, Isabel, Sarazin, Marie, Scheltens, Philip, Schröder, Johannes, Selnes, Per, Seo, Sang Won, Silva, Dina, Skoog, Ingmar, Snyder, Peter J., Soininen, Hilkka, Sollberger, Marc, Sperling, Reisa A., Spiru, Luisa, Stern, Yaakov, Stomrud, Erik, Takeda, Akitoshi, Teichmann, Marc, Teunissen, Charlotte E., Thompson, Louisa I., Tomassen, Jori, Tsolaki, Magda, Vandenberghe, Rik, Verbeek, Marcel M., Verhey, Frans R.J., Villemagne, Victor, Villeneuve, Sylvia, Vogelgsang, Jonathan, Waldemar, Gunhild, Wallin, Anders, Wallin, Åsa K., Wiltfang, Jens, Wolk, David A., Yen, Tzu Chen, Zboch, Marzena, Zetterberg, Henrik, Jansen, Willemijn J., Janssen, Olin, Tijms, Betty M., Vos, Stephanie J.B., Ossenkoppele, Rik, Visser, Pieter Jelle, Aarsland, Dag, Alcolea, Daniel, Altomare, Daniele, Von Arnim, Christine, Baiardi, Simone, Baldeiras, Ines, Barthel, Henryk, Bateman, Randall J., Van Berckel, Bart, Binette, Alexa Pichet, Blennow, Kaj, Boada, Merce, Boecker, Henning, Bottlaender, Michel, Den Braber, Anouk, Brooks, David J., Van Buchem, Mark A., Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Cohen, Ann D., Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L., Engelborghs, Sebastiaan, Epelbaum, Stéphane, Fagan, Anne M., Fan, Yong, Fladby, Tormod, Fleisher, Adam S., Van Der Flier, Wiesje M., Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Frisoni, Giovanni B., Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G., Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael T., Herukka, Sanna Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Huang, Chin Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J., Jessen, Frank, Johannsen, Peter, Johnson, Keith A., Kandimalla, Ramesh, Kapaki, Elisabeth N., Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E., Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G., Kuo, Hung Chou, Van Laere, Koen, Landau, Susan M., Landeau, Brigitte, Lee, Dong Young, De Leon, Mony, Leyton, Cristian E., Lin, Kun Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Marquié, Marta, Martinez-Lage, Pablo, Maserejian, Nancy, Mattsson, Niklas, De Mendonça, Alexandre, Meyer, Philipp T., Miller, Bruce L., Minatani, Shinobu, Mintun, Mark A., Mok, Vincent C.T., Molinuevo, Jose Luis, Morbelli, Silvia Daniela, Morris, John C., Mroczko, Barbara, Na, Duk L., Newberg, Andrew, Nobili, Flavio, Nordberg, Agneta, Olde Rikkert, Marcel G.M., De Oliveira, Catarina Resende, Olivieri, Pauline, Orellana, Adela, Paraskevas, George, Parchi, Piero, Pardini, Matteo, Parnetti, Lucilla, Peters, Oliver, Poirier, Judes, Popp, Julius, Prabhakar, Sudesh, Rabinovici, Gil D., Ramakers, Inez H., Rami, Lorena, Reiman, Eric M., Rinne, Juha O., Rodrigue, Karen M., Rodríguez-Rodriguez, Eloy, Roe, Catherine M., Rosa-Neto, Pedro, Rosen, Howard J., Rot, Uros, Rowe, Christopher C., Rüther, Eckart, Ruiz, Agustín, Sabri, Osama, Sakhardande, Jayant, Sánchez-Juan, Pascual, Sando, Sigrid Botne, Santana, Isabel, Sarazin, Marie, Scheltens, Philip, Schröder, Johannes, Selnes, Per, Seo, Sang Won, Silva, Dina, Skoog, Ingmar, Snyder, Peter J., Soininen, Hilkka, Sollberger, Marc, Sperling, Reisa A., Spiru, Luisa, Stern, Yaakov, Stomrud, Erik, Takeda, Akitoshi, Teichmann, Marc, Teunissen, Charlotte E., Thompson, Louisa I., Tomassen, Jori, Tsolaki, Magda, Vandenberghe, Rik, Verbeek, Marcel M., Verhey, Frans R.J., Villemagne, Victor, Villeneuve, Sylvia, Vogelgsang, Jonathan, Waldemar, Gunhild, Wallin, Anders, Wallin, Åsa K., Wiltfang, Jens, Wolk, David A., Yen, Tzu Chen, Zboch, Marzena, and Zetterberg, Henrik
- Abstract
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design. Objective: To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates. Design, Setting, and Participants: This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria. Exposures: Alzheimer disease biomarkers detected on PET or in CSF. Main Outcomes and Measures: Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations. Results: Among the 19097 participants (mean [SD] age, 69.1 [9.8] years; 10148 women [53.1%])
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- 2022
19. Prevalence Estimates of Amyloid Abnormality Across the Alzheimer Disease Clinical Spectrum
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Jansen, Willemijn J, Janssen, Olin, von Arnim, Christine, Marquié, Marta, Martinez-Lage, Pablo, Maserejian, Nancy, Mattsson, Niklas, de Mendonça, Alexandre, Meyer, Philipp T, Miller, Bruce L, Minatani, Shinobu, Mintun, Mark A, Mok, Vincent C T, Baiardi, Simone, Molinuevo, Jose Luis, Morbelli, Silvia Daniela, Morris, John C, Mroczko, Barbara, Na, Duk L, Newberg, Andrew, Nobili, Flavio, Nordberg, Agneta, Olde Rikkert, Marcel G M, de Oliveira, Catarina Resende, Baldeiras, Ines, Olivieri, Pauline, Orellana, Adela, Paraskevas, George, Parchi, Piero, Pardini, Matteo, Parnetti, Lucilla, Peters, Oliver, Poirier, Judes, Popp, Julius, Prabhakar, Sudesh, Barthel, Henryk, Rabinovici, Gil D, Ramakers, Inez H, Rami, Lorena, Reiman, Eric M, Rinne, Juha O, Rodrigue, Karen M, Rodríguez-Rodriguez, Eloy, Roe, Catherine M, Rosa-Neto, Pedro, Rosen, Howard J, Bateman, Randall J, Rot, Uros, Rowe, Christopher C, Rüther, Eckart, Ruiz, Agustín, Sabri, Osama, Sakhardande, Jayant, Sánchez-Juan, Pascual, Sando, Sigrid Botne, Santana, Isabel, Sarazin, Marie, Van Berckel, Bart, Scheltens, Philip, Schröder, Johannes, Selnes, Per, Seo, Sang Won, Silva, Dina, Skoog, Ingmar, Snyder, Peter J, Soininen, Hilkka, Sollberger, Marc, Sperling, Reisa A, Binette, Alexa Pichet, Spiru, Luisa, Stern, Yaakov, Stomrud, Erik, Takeda, Akitoshi, Teichmann, Marc, Teunissen, Charlotte E, Thompson, Louisa I, Tomassen, Jori, Tsolaki, Magda, Vandenberghe, Rik, Blennow, Kaj, Verbeek, Marcel M, Verhey, Frans R J, Villemagne, Victor, Villeneuve, Sylvia, Vogelgsang, Jonathan, Waldemar, Gunhild, Wallin, Anders, Wallin, Åsa K, Wiltfang, Jens, Wolk, David A, Boada, Merce, Yen, Tzu-Chen, Zboch, Marzena, Zetterberg, Henrik, Boecker, Henning, Tijms, Betty M, Bottlaender, Michel, den Braber, Anouk, Brooks, David J, Van Buchem, Mark A, Camus, Vincent, Carill, Jose Manuel, Cerman, Jiri, Chen, Kewei, Chételat, Gaël, Chipi, Elena, Vos, Stephanie J B, Cohen, Ann D, Daniels, Alisha, Delarue, Marion, Didic, Mira, Drzezga, Alexander, Dubois, Bruno, Eckerström, Marie, Ekblad, Laura L, Engelborghs, Sebastiaan, Epelbaum, Stéphane, Ossenkoppele, Rik, Fagan, Anne M, Fan, Yong, Fladby, Tormod, Fleisher, Adam S, Van der Flier, Wiesje M, Förster, Stefan, Fortea, Juan, Frederiksen, Kristian Steen, Freund-Levi, Yvonne, Frings, Lars, Visser, Pieter Jelle, Frisoni, Giovanni B, Fröhlich, Lutz, Gabryelewicz, Tomasz, Gertz, Hermann-Josef, Gill, Kiran Dip, Gkatzima, Olymbia, Gómez-Tortosa, Estrella, Grimmer, Timo, Guedj, Eric, Habeck, Christian G, Group, Amyloid Biomarker Study, Hampel, Harald, Handels, Ron, Hansson, Oskar, Hausner, Lucrezia, Hellwig, Sabine, Heneka, Michael, Herukka, Sanna-Kaisa, Hildebrandt, Helmut, Hodges, John, Hort, Jakub, Aarsland, Dag, Huang, Chin-Chang, Iriondo, Ane Juaristi, Itoh, Yoshiaki, Ivanoiu, Adrian, Jagust, William J, Jessen, Frank, Johannsen, Peter, Johnson, Keith A, Kandimalla, Ramesh, Kapaki, Elisabeth N, Alcolea, Daniel, Kern, Silke, Kilander, Lena, Klimkowicz-Mrowiec, Aleksandra, Klunk, William E, Koglin, Norman, Kornhuber, Johannes, Kramberger, Milica G, Kuo, Hung-Chou, Van Laere, Koen, Landau, Susan M, Altomare, Daniele, Landeau, Brigitte, Lee, Dong Young, de Leon, Mony, Leyton, Cristian E, Lin, Kun-Ju, Lleó, Alberto, Löwenmark, Malin, Madsen, Karine, Maier, Wolfgang, Marcusson, Jan, Clinical sciences, Neuroprotection & Neuromodulation, Neurology, Amsterdam Neuroscience - Brain Imaging, Amsterdam Neuroscience - Neurodegeneration, Radiology and nuclear medicine, Laboratory Medicine, Amsterdam Neuroscience - Neuroinfection & -inflammation, APH - Personalized Medicine, APH - Methodology, RS: MHeNs - R1 - Cognitive Neuropsychiatry and Clinical Neuroscience, and Psychiatrie & Neuropsychologie
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Male ,MILD COGNITIVE IMPAIRMENT ,epidemiology [Cognitive Dysfunction] ,positron emission tomography ,Alzheimer`s disease Donders Center for Medical Neuroscience [Radboudumc 1] ,epidemiology [Alzheimer Disease] ,Neuroscience(all) ,diagnostic imaging [Cognitive Dysfunction] ,Amyloidogenic Proteins ,tau Proteins ,cerebrospinal fluid [Amyloid beta-Peptides] ,DIAGNOSIS ,cerebrospinal fluid ,Apolipoproteins E ,Alzheimer Disease ,Prevalence ,Humans ,Amyloid, Alzheimer, PET ,Cognitive Dysfunction ,ddc:610 ,cerebrospinal fluid [Peptide Fragments] ,Aged ,Amyloid beta-Peptides ,neurology ,DEMENTIA ,Correction ,ASSOCIATION ,Amyloidosis ,Middle Aged ,Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3] ,health care planning ,clinical trial design ,Peptide Fragments ,cerebrospinal fluid [Alzheimer Disease] ,PET ,DRIFT ,Cross-Sectional Studies ,cerebrospinal fluid [Biomarkers] ,cerebrospinal fluid [tau Proteins] ,Radiology Nuclear Medicine and imaging ,Positron-Emission Tomography ,genetics [Apolipoproteins E] ,Female ,Neurology (clinical) ,diagnostic imaging [Alzheimer Disease] ,cerebral amyloid aggregation ,Biomarkers - Abstract
Importance: One characteristic histopathological event in Alzheimer disease (AD) is cerebral amyloid aggregation, which can be detected by biomarkers in cerebrospinal fluid (CSF) and on positron emission tomography (PET) scans. Prevalence estimates of amyloid pathology are important for health care planning and clinical trial design.Objective: To estimate the prevalence of amyloid abnormality in persons with normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia and to examine the potential implications of cutoff methods, biomarker modality (CSF or PET), age, sex, APOE genotype, educational level, geographical region, and dementia severity for these estimates.Design, Setting, and Participants: This cross-sectional, individual-participant pooled study included participants from 85 Amyloid Biomarker Study cohorts. Data collection was performed from January 1, 2013, to December 31, 2020. Participants had normal cognition, subjective cognitive decline, mild cognitive impairment, or clinical AD dementia. Normal cognition and subjective cognitive decline were defined by normal scores on cognitive tests, with the presence of cognitive complaints defining subjective cognitive decline. Mild cognitive impairment and clinical AD dementia were diagnosed according to published criteria.Exposures: Alzheimer disease biomarkers detected on PET or in CSF.Main Outcomes and Measures: Amyloid measurements were dichotomized as normal or abnormal using cohort-provided cutoffs for CSF or PET or by visual reading for PET. Adjusted data-driven cutoffs for abnormal amyloid were calculated using gaussian mixture modeling. Prevalence of amyloid abnormality was estimated according to age, sex, cognitive status, biomarker modality, APOE carrier status, educational level, geographical location, and dementia severity using generalized estimating equations.Results: Among the 19 097 participants (mean [SD] age, 69.1 [9.8] years; 10 148 women [53.1%]) included, 10 139 (53.1%) underwent an amyloid PET scan and 8958 (46.9%) had an amyloid CSF measurement. Using cohort-provided cutoffs, amyloid abnormality prevalences were similar to 2015 estimates for individuals without dementia and were similar across PET- and CSF-based estimates (24%; 95% CI, 21%-28%) in participants with normal cognition, 27% (95% CI, 21%-33%) in participants with subjective cognitive decline, and 51% (95% CI, 46%-56%) in participants with mild cognitive impairment, whereas for clinical AD dementia the estimates were higher for PET than CSF (87% vs 79%; mean difference, 8%; 95% CI, 0%-16%; P = .04). Gaussian mixture modeling-based cutoffs for amyloid measures on PET scans were similar to cohort-provided cutoffs and were not adjusted. Adjusted CSF cutoffs resulted in a 10% higher amyloid abnormality prevalence than PET-based estimates in persons with normal cognition (mean difference, 9%; 95% CI, 3%-15%; P = .004), subjective cognitive decline (9%; 95% CI, 3%-15%; P = .005), and mild cognitive impairment (10%; 95% CI, 3%-17%; P = .004), whereas the estimates were comparable in persons with clinical AD dementia (mean difference, 4%; 95% CI, -2% to 9%; P = .18).Conclusions and Relevance: This study found that CSF-based estimates using adjusted data-driven cutoffs were up to 10% higher than PET-based estimates in people without dementia, whereas the results were similar among people with dementia. This finding suggests that preclinical and prodromal AD may be more prevalent than previously estimated, which has important implications for clinical trial recruitment strategies and health care planning policies.
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- 2022
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20. Dynamic functional connectivity patterns associated with dementia risk
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Dautricourt, Sophie, Gonneaud, Julie, Landeau, Brigitte, Calhoun, Vince D., de Flores, Robin, Poisnel, Géraldine, Bougacha, Salma, Ourry, Valentin, Touron, Edelweiss, Kuhn, Elizabeth, Demintz-King, Harriet, Marchant, Natalie L., Vivien, Denis, de la Sayette, Vincent, Lutz, Antoine, Chételat, Gaël, Arenaza-Urquijo, Eider M., Allais, Florence, André, Claire, Asselineau, Julien, Bejanin, Alexandre, Champetier, Pierre, Chocat, Anne, Delarue, Marion, Egret, Stéphanie, Felisatti, Francesca, Devouge, Eglantine Ferrand, Frison, Eric, Heidmann, Marc, Tran, Thien Huong, le Du, Gwendoline, Lefranc, Valérie, Mezenge, Florence, Moulinet, Inès, Palix, Cassandre, Paly, Léo, Quillard, Anne, Rauchs, Géraldine, Rehel, Stéphane, Requier, Florence, Ware, Caitlin, Lugo, Sebastian Baez, Klimecki, Olga, Vuilleumier, Patrik, Barnhofer, Thorsten, Collette, Fabienne, Salmon, Eric, Delamillieure, Pascal, Batchelor, Martine, Beaugonin, Axel, Gheysen, Francis, Demnitz-King, Harriet, Marchant, Natalie, Whitfield, Tim, Schimmer, Corinne, and Wirth, Miranka
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Brain Mapping ,Neurology ,Cognitive Neuroscience ,Brain ,Humans ,Dementia ,Neurology (clinical) ,Cholesterol, LDL ,Magnetic Resonance Imaging ,Aged - Abstract
Background This study assesses the relationships between dynamic functional network connectivity (DFNC) and dementia risk. Methods DFNC of the default mode (DMN), salience (SN), and executive control networks was assessed in 127 cognitively unimpaired older adults. Stepwise regressions were performed with dementia risk and protective factors and biomarkers as predictors of DFNC. Results Associations were found between times spent in (i) a “weakly connected” state and lower self-reported engagement in early- and mid-life cognitive activity and higher LDL cholesterol; (ii) a “SN-negatively connected” state and higher blood pressure, higher depression score, and lower body mass index (BMI); (iii) a “strongly connected” state and higher self-reported engagement in early-life cognitive activity, Preclinical Alzheimer’s cognitive composite-5 score, and BMI; and (iv) a “DMN-negatively connected” state and higher self-reported engagement in early- and mid-life stimulating activities and lower LDL cholesterol and blood pressure. The lower number of state transitions was associated with lower brain perfusion. Conclusion DFNC states are differentially associated with dementia risk and could underlie reserve.
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- 2022
21. Plus-value du résidentiel, se donner le temps d'agir dans la durée : une rencontre à l'interface recherche-clinique
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Deniel, Simon, Miquel, Maïlys, Quételard, Louise, Longbottom, Susie, Lozé, Stéphane, Rayneau, Jonathan, Jaunet, Héloïse, Delarue, Marion, Ritz, Ludivine, Beaunieux, Hélène, Bourguignon, Nicolas, and DENIEL, Simon
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[SHS.PSY] Humanities and Social Sciences/Psychology ,[SCCO.PSYC] Cognitive science/Psychology ,[SCCO.NEUR] Cognitive science/Neuroscience ,[SCCO] Cognitive science ,[SHS] Humanities and Social Sciences - Published
- 2022
22. Additional file 1 of Effects of a mindfulness-based versus a health self-management intervention on objective cognitive performance in older adults with subjective cognitive decline (SCD): a secondary analysis of the SCD-Well randomized controlled trial
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Whitfield, Tim, Demnitz-King, Harriet, Schlosser, Marco, Barnhofer, Thorsten, Frison, Eric, Coll-Padros, Nina, Dautricourt, Sophie, Requier, Florence, Delarue, Marion, Gonneaud, Julie, Klimecki, Olga M., Lutz, Antoine, Paly, Léo, Salmon, Eric, Schild, Ann-Katrin, Walker, Zuzana, Jessen, Frank, Chételat, Gaël, Collette, Fabienne, Wirth, Miranka, and Marchant, Natalie L.
- Abstract
Additional file 1. Supplementary Methods. Supplementary Results. Table S1. Collinearity diagnostics for alternate specifications of the cognitive retest effect variable. Table S2. Unadjusted (observed) and model-adjusted means for each trial arm at each timepoint (composite and individual cognitive outcomes). Table S3. Linear mixed models fitted using a linear and factorial time specification, respectively (individual outcomes only – see main paper Table 2 for composite outcomes). Table S4. Association between candidate predictors and baseline (week 0) to follow-up (week 24) change scores on composite outcomes, broken down by trial arm. Table S5. Pooled linear mixed models derived from analyses of multiply-imputed SCD-Well trial data (m = 5). Figure S1. Missing data pattern for the ‘wide’ format dataset. Figure S2. Estimated change in individual cognitive tests for each trial arm (linear-time specification). Figure S3. Estimated change in individual cognitive tests for each trial arm (linear-time specification).
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- 2022
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23. Les capacités émotionnelles des résidents accueillis en communautés thérapeutiques : mieux comprendre pour mieux accompagner
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Jaunet, Héloïse, Deniel, Simon, Quételard, Louise, Miquel, Maïlys, Delarue, Marion, Rayneau, Jonathan, Lozé, Stéphane, Bourguignon, Nicolas, Longbottom, Susie, Beaunieux, Hélène, Ritz, Ludivine, and DENIEL, Simon
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[SHS.PSY] Humanities and Social Sciences/Psychology ,[SCCO.PSYC] Cognitive science/Psychology ,[SCCO] Cognitive science ,[SHS] Humanities and Social Sciences - Published
- 2022
24. De la neuropsychologie expérimentale à la clinique : le projet NeuroAddiCT
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Jaunet, Héloïse, Quételard, Louise, Deniel, Simon, Delarue, Marion, Beaunieux, Hélène, Ritz, Ludivine, DENIEL, Simon, Communauté Thérapeutique d'Aubervilliers-Association Aurore, Communauté Thérapeutique de la Sauvegarde du Nord, Laboratoire de psychologie de Caen Normandie (LPCN), Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)
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[SHS.PSY] Humanities and Social Sciences/Psychology ,[SCCO]Cognitive science ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.PSYC]Cognitive science/Psychology ,[SCCO.PSYC] Cognitive science/Psychology ,[SCCO.NEUR] Cognitive science/Neuroscience ,[SHS.PSY]Humanities and Social Sciences/Psychology ,[SCCO] Cognitive science ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2022
25. Neuropsychology of addiction in Therapeutic Communities: a specific cognitive semiology ?
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Deniel, Simon, Delarue, Marion, Longbottom, Susie, Quételard, Louise, Lozé, Stéphane, Miquel, Maïlys, Bourguignon, Nicolas, Dupuis, Juliette, Beaunieux, Hélène, Ritz, Ludivine, Laboratoire de psychologie de Caen Normandie (LPCN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), and DENIEL, Simon
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[SHS.PSY] Humanities and Social Sciences/Psychology ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.PSYC] Cognitive science/Psychology ,[SCCO.NEUR] Cognitive science/Neuroscience ,[SCCO.PSYC]Cognitive science/Psychology ,[SHS.PSY]Humanities and Social Sciences/Psychology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2021
26. La neuropsychologie comme outil clinique en communautés thérapeutiques spécialisées en addictologie
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Deniel, Simon, Delarue, Marion, Benaceur, Younes, Longbottom, Susie, Quételard, Louise, Lozé, Stéphane, Miquel, Maïlys, Bourguignon, Nicolas, Dupuis, Juliette, Beaunieux, Hélène, Ritz, Ludivine, Laboratoire de psychologie de Caen Normandie (LPCN), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU), Communauté Thérapeutique d'Aubervilliers-Association Aurore, CommunautéThérapeutique d'Aubervilliers-Association Aurore, Communauté Thérapeutique de la Sauvegarde du Nord, Communauté Thérapeutique du Fleuve-CEID Addictions, Fédération Addiction, and DENIEL, Simon
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[SHS.PSY] Humanities and Social Sciences/Psychology ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SCCO.PSYC] Cognitive science/Psychology ,[SCCO.PSYC]Cognitive science/Psychology ,[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SHS.PSY]Humanities and Social Sciences/Psychology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2021
27. Braincharts for the human lifespan
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Bethlehem, Richard AI, Seidlitz, Jakob, Astle, Duncan E, Li, Jiao, Liao, Wei, Linares, Deirel P, Liston, Conor, Lombardo, Michael V, Lv, Jinglei, Lynch, Charles, Mallard, Travis T, Marcelis, Machteld, Markello, Ross D, Auyeung, Bonnie, Mazoyer, Bernard, McGuire, Philip, Meaney, Michael J, Mechelli, Andrea, Medic, Nenad, Misic, Bratislav, Morgan, Sarah E, Mothersill, David, Nigg, Joel, Ong, Marcus QW, Ayub, Muhammad, Ortinau, Cynthia, Ossenkoppele, Rik, Ouyang, Minhui, Palaniyappan, Lena, Paly, Leo, Pan, Pedro M, Pantelis, Christos, Park, Min Tae M, Paus, Tomas, Pausova, Zdenka, Ball, Gareth, Binette, Alexa Pichet, Pierce, Karen, Qian, Xing, Qiu, Anqi, Qiu, Jiang, Raznahan, Armin, Rittman, Timothy, Rollins, Caitlin K, Romero-Garcia, Rafael, Ronan, Lisa, Baron-Cohen, Simon, Rosenberg, Monica D, Rowitch, David H, Salum, Giovanni A, Satterthwaite, Theodore D, Schaare, Lina, Schachar, Russell J, Scholl, Michael, Schultz, Aaron P, Schumann, Gunter, Sharp, David, Beare, Richard, Bedford, Saashi A, Benegal, Vivek, Beyer, Frauke, Bae, Jong Bin, White, Simon R, Blangero, John, Cabez, Manuel Blesa, Boardman, James P, Borzage, Matthew, Bosch-Bayard, Jorge F, Bourke, Niall, Calhoun, Vince D, Chakravarty, Mallar M, Chen, Christina, Chertavian, Casey, Vogel, Jacob W, Chetelat, Gael, Chong, Yap S, Cole, James H, Corvin, Aiden, Courchesne, Eric, Crivello, Fabrice, Cropley, Vanessa L, Crosbie, Jennifer, Crossley, Nicolas, Delarue, Marion, Anderson, Kevin M, Desrivieres, Sylvane, Devenyi, Gabriel, Biase, Maria A Di, Dolan, Ray, Donald, Kirsten A, Donohoe, Gary, Dunlop, Katharine, Edwards, Anthony D, Elison, Jed T, Ellis, Cameron T, Adamson, Chris, Elman, Jeremy A, Eyler, Lisa, Fair, Damien A, Fletcher, Paul C, Fonagy, Peter, Franz, Carol E, Galan-Garcia, Lidice, Gholipour, Ali, Giedd, Jay, Gilmore, John H, Adler, Sophie, Glahn, David C, Goodyer, Ian, Grant, PE, Groenewold, Nynke A, Gunning, Faith M, Gur, Raquel E, Gur, Ruben C, Hammill, Christopher F, Hansson, Oskar, Hedden, Trey, Alexopoulos, George S, Heinz, Andreas, Henson, Richard, Heuer, Katja, Hoare, Jacqueline, Holla, Bharath, Holmes, Avram J, Holt, Rosie, Huang, Hao, Im, Kiho, Ipser, Jonathan, Anagnostou, Evdokia, Jack, Clifford R, Jackowski, Andrea P, Jia, Tianye, Johnson, Keith A, Jones, David T, Jones, Peter B, Kahn, Rene, Karlsson, Hasse, Karlsson, Linnea, Kawashima, Ryuta, Areces-Gonzalez, Ariosky, Kelley, Elizabeth A, Kern, Silke, Kim, KW, Kitzbichler, Manfred G, Kremen, William S, Lalonde, Francois, Landeau, Brigitte, Lee, Subin, Lerch, Jason, and Lewis, John D
- Abstract
Over the past 25 years, neuroimaging has become a ubiquitous tool in basic research and clinical studies of the human brain. However, there are no reference standards against which to anchor measures of individual differences in brain morphology, in contrast to growth charts for traits such as height and weight. Here, we built an interactive online resource (www.brainchart.io) to quantify individual differences in brain structure from any current or future magnetic resonance imaging (MRI) study, against models of expected age-related trends. With the goal of basing these on the largest and most inclusive dataset, we aggregated MRI data spanning 115 days post-conception through 100 postnatal years, totaling 122,123 scans from 100,071 individuals in over 100 studies across 6 continents. When quantified as centile scores relative to the reference models, individual differences show high validity with non-MRI brain growth estimates and high stability across longitudinal assessment. Centile scores helped identify previously unreported brain developmental milestones and demonstrated increased genetic heritability compared to non-centiled MRI phenotypes. Crucially for the study of brain disorders, centile scores provide a standardised and interpretable measure of deviation that reveals new patterns of neuroanatomical differences across neurological and psychiatric disorders emerging during development and ageing. In sum, brain charts for the human lifespan are an essential first step towards robust, standardised quantification of individual variation and for characterizing deviation from age-related trends. Our global collaborative study …
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- 2021
28. Circulating Stress Hormones, Brain Health, and Cognition in Healthy Older Adults: Cross-Sectional Findings and Sex Differences in the Age-Well Clinical Trial
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Liebscher, Maxie, White, Silke, Hass, Simon, Chocat, Anne, Mezenge, Florence, Landeau, Brigitte, Delarue, Marion, Hébert, Oriane, Turpin, Anne-Laure, Marchant, Natalie L., Chételat, Gaël, Klimecki, Olga, Poisnel, Géraldine, Wirth, Miranka, André, Claire, Champetier, Pierre, Chauveau, Léa, Collette, Fabienne, Dautricourt, Sophie, de Flores, Robin, De La Sayette, Vincent, Demnitz-King, Harriet, Fauvel, Séverine, Felisatti, Francesca, Ferment, Victor, Ferrand-Devouge, Eglantine, Gonneaud, Julie, Garnier-Crussard, Antoine, Hamel, Anaïs, Haudry, Sacha, Krolak-Salmon, Pierre, Kuhn, Elizabeth, Lefranc, Valérie, Lutz, Antoine, Ourry, Valentin, Palix, Cassandre, Quillard, Anne, Rauchs, Géraldine, Salmon, Eric, Touron, Edelweiss, Vuilleumier, Patrik, and Whitfield, Tim
- Abstract
Increased stress is a proposed risk factor for Alzheimer’s disease (AD). We examined cross-sectional associations between circulating stress biomarkers and multimodal measures of brain health and cognitive susceptibility to AD in older adults and sex-specific subgroups.
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- 2025
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29. Effect of an 18-Month Meditation Training on Telomeres in Older Adults: A Secondary Analysis of the Age-Well Randomized Controlled Trial
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Kaliman, Perla, Álvarez-López, María Jesús, Lehodey, Asrar, Fernández, Daniel, Chocat, Anne, Schlosser, Marco, de La Sayette, Vincent, Vivien, Denis, Marchant, Natalie L., Chételat, Gael, Lutz, Antoine, Poisnel, Géraldine, André, Claire, Lugo, Sebastian Baez, Batchelor, Martine, Beaugonin, Axel, Champetier, Pierre, Chauveau, Léa, Chételat, Gael, Chocat, Anne, Collette, Fabienne, De Florès, Robin, de La Sayette, Vincent, Delarue, Marion, Fauvel, Séverine, Felisatti, Francesca, Devouge, Eglantine Ferrand, Frison, Eric, Gonneaud, Julie, Tran, Thien Huong, Kaliman, Perla, Klimecki, Olga, Kuhn, Elizabeth, Landeau, Brigitte, Lefranc, Valérie, Lehodey, Asrar, Lutz, Antoine, Marchant, Natalie, Mezenge, Florence, Ourry, Valentin, Palix, Cassandre, Poisnel, Géraldine, Quillard, Anne, Rauchs, Géraldine, Salmon, Eric, Schimmer, Corinne, Touron, Edelweiss, Turpin, Anne-Laure, and Vuilleumier, Patrik
- Abstract
Shorter telomeres are associated with increased risk of cognitive decline and age-related diseases. Developing interventions to promote healthy aging by preserving telomere integrity is of paramount importance. Here, we investigated the effect of an 18-month meditation intervention on telomere length (TL) measures in older people without cognitive impairment.
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- 2025
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30. La richesse du clip vidéo : réemplois et reprises
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Delarue, Marion, Aix-Marseille Université - Département Sciences, Arts et Techniques des Images et du Son (AMU SATIS), Aix Marseille Université (AMU), and Frédérique Devaux Amarger
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Clip Vidéo ,Références ,Choix de réalisation et de montage ,Reapply ,Musique ,References ,Reprises ,[SHS]Humanities and Social Sciences ,Creativity ,Réception ,Influence ,Réemplois ,Choices of direction andediting ,Videoclip ,Music ,Reception - Abstract
Being entertaining as well as fascinating and with a strong aesthetic value, the video clip presents a hybrid format, somewhere between useful advertising and pure cinematographic aesthetics. The clip appears as an art in itself which found inspiration from a wide range of influences in order to create its own balance and language. As such its quite singular content is very recognizable. This thesis focuses on the different kinds of inspirations that have been able to impact and nurture the video clip: what inspirations, what references and, therefore, what Reapply and Retake ?; À la fois distrayant, captivant, et à forte valeur esthétique, le clip vidéo se constitue comme un format hybride, entre utilité publicitaire et esthétique cinématographique. Le clip apparaît comme un art en marge qui s’est inspiré de différentes formes pour se former son équilibre et son propre langage. Il propose ainsi un contenu singulier très reconnaissable. Ce mémoire porte sur les différents genres d’inspirations qui ont su impacter et nourrir le clip vidéo : quelles inspirations, quelles références et, par-là, quels Réemplois et Reprises ?
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- 2020
31. Additional file 1 of White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition
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Garnier-Crussard, Antoine, Bougacha, Salma, Miranka Wirth, André, Claire, Delarue, Marion, Landeau, Brigitte, Mézenge, Florence, Kuhn, Elizabeth, Gonneaud, Julie, Chocat, Anne, Quillard, Anne, Ferrand-Devouge, Eglantine, Sayette, Vincent De La, Vivien, Denis, Krolak-Salmon, Pierre, and Chételat, Gaël
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mental disorders ,behavioral disciplines and activities - Abstract
Additional file 1: Table S1 Demographic, clinical and neuroimaging data in the subgroup of young/middle-aged adults and in the subgroup of older adults. Figure S1. Correlation matrices. Figure S2 Relationships between regional WMH and age in the subgroup of young/middle-aged adults and in the subgroup of older adults, and interactive effects between age groups. Table S2 Relationships between WMH, vascular risk factors and Aβ in the subgroup of young adults ≤40 years. Figure S3 Total WMH as a function of age in adults younger than 40 years old. Table S3 Associations between WMH and cognition in the whole sample.
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- 2020
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32. A specific gait profile under dual-task condition in injured older fallers
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Kristell, Pothier, Langeard, Antoine, Chavoix, Chantal, Delarue, Marion, Michel, Murielle, Marcelli, Christian, DELARUE, Marion, Mobilités : Attention, Orientation et Chronobiologie (COMETE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Rhumatologie [CHU Caen], Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Mobilités : Vieillissement, Pathologie, Santé (COMETE), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Caen Normandie (UNICAEN), and Normandie Université (NU)-Normandie Université (NU)
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030214 geriatrics ,[SDV.NEU.PC]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,[SCCO.NEUR]Cognitive science/Neuroscience ,[SCCO.NEUR] Cognitive science/Neuroscience ,[SDV.NEU.PC] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]/Psychology and behavior ,General Medicine ,03 medical and health sciences ,0302 clinical medicine ,[SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,030212 general & internal medicine ,Geriatrics and Gerontology ,Gerontology ,ComputingMilieux_MISCELLANEOUS - Abstract
International audience
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- 2016
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33. ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER’S DISEASE
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Kuhn, Elizabeth, De la Sayette, Vincent, Perrotin, Audrey, Tomadesso, Clémence, André, Claire, Sherif, Siya, Bejanin, Alexandre, Moulinet, Inès, Touron, Edelweiss, Landeau, Brigitte, Mézenge, Florence, Marchant, Natalie L., Delarue, Marion, Delcroix, Nicolas, Abbas, Ahmed, Manrique, Alain, Eustache, Francis, Vivien, Denis, and Chetelat, Gaelle
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- 2019
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34. The effect of a mindfulness‐based versus health self‐management intervention on cognitive performance in older adults with subjective cognitive decline (SCD): The SCD‐Well randomized controlled trial.
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Whitfield, Tim, Demnitz‐King, Harriet, Schlosser, Marco, Barnhofer, Thorsten, Collette, Fabienne, Dautricourt, Sophie, Delarue, Marion, Frison, Eric, Gonneaud, Julie, Klimecki, Olga M, Lutz, Antoine, Paly, Léo, Poisnel, Géraldine, Salmon, Eric, Schild, Ann‐Katrin, Walker, Zuzana, Wirth, Miranka, Chetelat, Gaël, Jessen, Frank, and Marchant, Natalie L
- Abstract
Background: Subjective cognitive decline (SCD) denotes self‐reported cognitive concerns in the absence of objective cognitive impairment. Individuals with SCD convert to dementia at twice the annual rate of healthy controls, with relatively poorer cognition in SCD conferring additional risk. Non‐pharmacological interventions are currently undergoing intensive evaluation for promoting cognitive function in SCD. Method: This study utilized data from the SCD‐Well randomized controlled trial. One hundred forty‐seven older adults with SCD, recruited from clinics in four European countries, were randomized to one of two 8‐week non‐pharmacological interventions: the Caring Mindfulness‐Based Approach for Seniors (CMBAS), or a Health Self‐Management Program (HSMP). Participants' objective cognitive performance was assessed at baseline, post‐intervention, and 24‐weeks follow‐up using a battery of tests. Four of these (RAVLT, WAIS‐IV Coding, Mattis DRS‐2 and Category Fluency) were combined to yield an abridged version of the Preclinical Alzheimer's Cognitive Composite 5 (PACC5Abridged). Linear mixed models estimated the change in outcome measures (the PACC5Abridged and its constituents) within and between arms. All models were adjusted for country and participant demographics (sex, age, and education), as well as the time‐varying effect of participants' repeated practice with the outcome measures. Result: There was a statistically significant improvement in the PACC5Abridged in both arms of the trial (p<.001), which did not differ between groups. The mean change in PACC5Abridged from baseline to 24‐weeks was 0.28 for CMBAS, and 0.22 for HSMP (pooled baseline SD 0.72). The effect of participants' repeated practice on the PACC5Abridged was non‐significant, ruling out retest effects as a substantive explanation for results. Amongst the PACC5Abridged constituent tests, significant improvement was observed in the RAVLT and WAIS‐IV Coding. Conclusion: This clinical trial evaluated the effect of two 8‐week non‐pharmacological interventions on objective cognitive performance in SCD. Scores on a composite measure of early Alzheimer's disease related cognitive dysfunction improved in both arms, even after accounting for practice effects. These results paralleled those of the primary outcome measure (trait anxiety), for which scores also improved in both arms. This work adds to the growing body of evidence that non‐pharmacological interventions can impact cognition in individuals at increased risk of dementia. [ABSTRACT FROM AUTHOR]
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- 2021
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35. Neuroticism is the best predictor of lower emotional resilience during the COVID‒19‐related confinement periods.
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Gonneaud, Julie, Paly, Léo, Delarue, Marion, Mézenge, Florence, Fauvel, Séverine, Lefranc, Valérie, Cognet, Aurélia, de Flores, Robin, Touron, Edelweiss, Marchant, Natalie L, Poisnel, Géraldine, and Chetelat, Gaël
- Abstract
Background: The COVID‐19 pandemic and the associated distancing measures dramatically affect psychoaffective health, and this is accentuated in older adults who are more vulnerable to the situation. In this study, we are interested in the predictors of emotional resilience in healthy older adults, and also on how the repetition of confinement periods could influence this resilience and its predictors. Method: 102 cognitively unimpaired older adults from the Age‐Well cohort were included. They all completed the Depression Anxiety Stress Scales (DASS‐42) during each period of national confinement (April and November 2020), used here as a measure of emotional resilience (lower scores indicating greater resilience). Baseline measures from the Age‐Well study, all acquired before the pandemic, were used as predictors, including demographics (age, sex, education), personality (Big Five Inventory), psychological (anxiety [STAI‐B], depression [GDS]), lifestyle (Lifetime of experience questionnaire), global cognitive functioning (Mattis‐DRS) and neuroimaging data (hippocampal volume, brain perfusion, amyloid burden). We ran stepwise regressions to predict emotional resilience during the first confinement. Then, we used paired t‐test to assess the evolution of emotional resilience between the two confinements. Finally, we replicated the stepwise regressions to predict changes in resilience over time ('second‐minus‐first' confinement). Result: Neuroticism was the only significant predictor of the DASS‐42 score during the first confinement (β=.48; p<.001; Figure‐1), lower neuroticism being associated with better resilience. We found the DASS‐42 score to increase significantly from the first to the second confinement, indicating decreased emotional resilience over time. Moreover, higher neuroticism (β=.53; p<.001) and higher agreeableness (β=.20; p=.03) were associated with higher DASS‐42 increase over time (Figure‐2). Conclusion: Our study suggests that lower neuroticism is the main predictor of greater emotional resilience to the COVID‐19‐related confinement. Importantly, the repetition of the confinement situation is associated with a decrease in emotional resilience in older adults, especially if they are prone to experience distress (neuroticism) or have a particularly social personality (agreeableness). Overall, these results underline the increasing need, as the crisis persists, for a psychoaffective support of older adult. [ABSTRACT FROM AUTHOR]
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- 2021
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36. Effect of cognitive reserve and amyloid deposition on sleep‐dependent cognition in older adults.
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Ourry, Valentin, Rehel, Stéphane, André, Claire, Gonneaud, Julie, Moulinet, Inès, Kuhn, Elizabeth, Touron, Edelweiss, Landeau, Brigitte, Mézenge, Florence, Paly, Léo, Delarue, Marion, De la Sayette, Vincent, Chetelat, Gaël, and Rauchs, Géraldine
- Abstract
Background: Sleep, especially slow wave sleep (SWS), favors efficient cognitive functioning. This effect may be impaired in aging, but might be modulated by cognitive reserve. Indeed, a study reported that highly educated older adults were able to better tolerate the negative effects of subjective sleep disturbances on verbal fluency scores. Growing evidence also suggests that sleep may favor amyloid clearance. In this context, we investigated the effect of cognitive reserve and amyloid deposition on the links between SWS and cognitive performance in older adults. Methods: Baseline data of 135 cognitively unimpaired older adults (mean age ± SD: 69.3 ± 3.8 y) from the Age‐Well cohort were analysed. Participants underwent a neuropsychological assessment, a polysomnography, and a florbetapir PET scan to measure amyloid deposition. Cognitive reserve was estimated using a socio‐behavioral proxy, the Lifetime of Experiences Questionnaire. We conducted linear regressions between SWS (% of total sleep time) and 1) executive functions and 2) episodic memory composite scores. Standardized residuals were extracted so that higher values reflect a better cognition than expected (i.e., greater cognitive resilience). Then, we performed linear regressions with these residuals as dependent variables and cognitive reserve or amyloid deposition as independent variables. Analyses were repeated with age, sex and the apnea‐hypopnea index as covariates. Results: SWS (%) was positively associated with executive functions (p=0.021) and episodic memory (p=0.017) composite scores (Figure 1). For both cognitive domains, higher residuals were associated with better cognitive reserve and lower amyloid deposition (p<0.05) (Figure 2). All links with cognitive reserve remained significant after controlling for the covariates (p<0.05), while those with amyloid deposition were close to the significance threshold (p=0.085 and p=0.054 for executive functions and episodic memory respectively). Conclusions: Individuals with higher cognitive reserve or, to a lesser extent, lower amyloid deposition, were able to better tolerate the effects of low amounts of SWS on executive and episodic memory performance. Cognitive reserve may help maintaining cognitive performance even when sleep is disrupted (i.e., cognitive resilience to sleep changes), while amyloid deposition would increase the vulnerability to poor sleep quality. These findings are important to understand the factors promoting successful aging. [ABSTRACT FROM AUTHOR]
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- 2021
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37. P4‐295: ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER'S DISEASE.
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Kuhn, Elizabeth, De la Sayette, Vincent, Perrotin, Audrey, Tomadesso, Clémence, Andre, Claire, Sherif, Siya, Bejanin, Alexandre, Moulinet, Inès, Touron, Edelweiss, Landeau, Brigitte, Mézenge, Florence, Marchant, Natalie L., Delarue, Marion, Delcroix, Nicolas, Abbas, Ahmed, Manrique, Alain, Eustache, Francis, Vivien, Denis, and Chetelat, Gaelle
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- 2019
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38. IC‐P‐082: ASSOCIATION OF PERCEIVED MEMORY DECLINE WITH MULTIMODAL NEUROIMAGING AT DIFFERENT STAGES OF ALZHEIMER'S DISEASE.
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Kuhn, Elizabeth, De la Sayette, Vincent, Perrotin, Audrey, Tomadesso, Clémence, André, Claire, Sherif, Siya, Bejanin, Alexandre, Moulinet, Inès, Touron, Edelweiss, Landeau, Brigitte, Mézenge, Florence, Marchant, Natalie L., Delarue, Marion, Delcroix, Nicolas, Abbas, Ahmed, Manrique, Alain, Eustache, Francis, Vivien, Denis, and Chetelat, Gaelle
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- 2019
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39. White matter hyperintensities across the adult life span: Links with age, amyloid load and cognition: Neuropsychology/Neuropsychological profiles of dementia: Valid biomarkers?
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Garnier‐Crussard, Antoine, Bougacha, Salma, Wirth, Miranka, Andre, Claire, Delarue, Marion, Landeau, Brigitte, Mézenge, Florence, Kuhn, Elizabeth, Gonneaud, Julie, Chocat, Anne, Quillard, Anne, Devouge, Eglantine Ferrand, Sayette, Vincent De, Vivien, Denis, Salmon, Pierre Krolak, and Chetelat, Gael
- Abstract
Background: Brain white matter hyperintensities (WMH) are frequent in older adults, including cognitively unimpaired individuals and are associated to decreased cognitive performances. The prevalence of WMH and their links with cognitive performance and with cortical β‐amyloid (Aβ) burden have been rarely assessed in younger adults. The aim of this study was to assess the impact of WMH in younger and older cognitively unimpaired adults on cognitive performances and the possible interaction with cortical β‐amyloid (Aβ) burden. Method: Two hundred and seventy‐two cognitively unimpaired adults from the community (from the IMAP study and the Age‐Well trial) were enrolled and age‐stratified in 86 younger adults (YA; ≤60 years old) and 187 older adults (OA; >60 years old). All participants underwent i) a comprehensive neuropsychological assessment allowing to obtain composite scores of episodic memory, processing speed, working memory, executive functions, and global cognition; ii) brain structural T1 and FLAIR MRI scans used for automatic segmentation of WMH volumes; and iii) a Florbetapir‐PET scan to measure cortical Aβ. Within each group, the relationships of total and regional WMH to age and cognition were assessed, as well as the impact of cortical Aβ on these relationships. Result: WMH increased with age in both groups but more sharply in OA than YA, particularly in the parietal lobe. Higher WMH volume was associated to worse cognitive performances in both groups. Particularly, working memory, processing speed and global cognition were negatively associated with global and regional WMH in YA and executive functions were negatively associated to occipital WMH in OA. Cortical Aβ differentially impacts the links between WMH and cognition in YA versus OA. Conclusion: WMH volume increases with age and is negatively associated to cognitive performances including in YA. This study argues for the clinical relevance of WMH even in middle age. [ABSTRACT FROM AUTHOR]
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- 2020
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40. Characteristics of subjective cognitive decline associated with amyloid positivity
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Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J. B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleo, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chetelat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort-Merino, Adria, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sanchez-Saudinos, M. Belen, Ebenau, Jarith, Pocnet, Cornelia, Eckerstrom, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne, Wallin, Asa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, Visser, Pieter Jelle, Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J. B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleo, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chetelat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort-Merino, Adria, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sanchez-Saudinos, M. Belen, Ebenau, Jarith, Pocnet, Cornelia, Eckerstrom, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne, Wallin, Asa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, and Visser, Pieter Jelle
- Abstract
Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
41. Characteristics of subjective cognitive decline associated with amyloid positivity
- Author
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Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J. B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleo, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chetelat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort-Merino, Adria, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sanchez-Saudinos, M. Belen, Ebenau, Jarith, Pocnet, Cornelia, Eckerstrom, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne, Wallin, Asa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, Visser, Pieter Jelle, Janssen, Olin, Jansen, Willemijn J., Vos, Stephanie J. B., Boada, Merce, Parnetti, Lucilla, Gabryelewicz, Tomasz, Fladby, Tormod, Molinuevo, Jose Luis, Villeneuve, Sylvia, Hort, Jakub, Epelbaum, Stephane, Lleo, Alberto, Engelborghs, Sebastiaan, van der Flier, Wiesje M., Landau, Susan, Popp, Julius, Wallin, Anders, Scheltens, Philip, Rikkert, Marcel Olde, Snyder, Peter J., Rowe, Chris, Chetelat, Gael, Ruiz, Agustin, Marquie, Marta, Chipi, Elena, Wolfsgruber, Steffen, Heneka, Michael, Boecker, Henning, Peters, Oliver, Jarholm, Jonas, Rami, Lorena, Tort-Merino, Adria, Binette, Alexa Pichet, Poirier, Judes, Rosa-Neto, Pedro, Cerman, Jiri, Dubois, Bruno, Teichmann, Marc, Alcolea, Daniel, Fortea, Juan, Sanchez-Saudinos, M. Belen, Ebenau, Jarith, Pocnet, Cornelia, Eckerstrom, Marie, Thompson, Louisa, Villemagne, Victor, Buckley, Rachel, Burnham, Samantha, Delarue, Marion, Freund-Levi, Yvonne, Wallin, Asa K., Ramakers, Inez, Tsolaki, Magda, Soininen, Hilkka, Hampel, Harald, Spiru, Luiza, Tijms, Betty, Ossenkoppele, Rik, Verhey, Frans R. J., Jessen, Frank, and Visser, Pieter Jelle
- Abstract
Introduction The evidence for characteristics of persons with subjective cognitive decline (SCD) associated with amyloid positivity is limited. Methods In 1640 persons with SCD from 20 Amyloid Biomarker Study cohort, we investigated the associations of SCD-specific characteristics (informant confirmation, domain-specific complaints, concerns, feelings of worse performance) demographics, setting, apolipoprotein E gene (APOE) epsilon 4 carriership, and neuropsychiatric symptoms with amyloid positivity. Results Between cohorts, amyloid positivity in 70-year-olds varied from 10% to 76%. Only older age, clinical setting, and APOE epsilon 4 carriership showed univariate associations with increased amyloid positivity. After adjusting for these, lower education was also associated with increased amyloid positivity. Only within a research setting, informant-confirmed complaints, memory complaints, attention/concentration complaints, and no depressive symptoms were associated with increased amyloid positivity. Feelings of worse performance were associated with less amyloid positivity at younger ages and more at older ages. Discussion Next to age, setting, and APOE epsilon 4 carriership, SCD-specific characteristics may facilitate the identification of amyloid-positive individuals.
42. Exposure to negative socio-emotional events induces sustained alteration of resting-state brain networks in older adults
- Author
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Baez-Lugo, Sebastian, Deza-Araujo, Yacila I, Maradan, Christel, Collette, Fabienne, Lutz, Antoine, Marchant, Natalie L, Chételat, Gaël, Vuilleumier, Patrik, Klimecki-Lenz, Olga Maria, Group, Medit-Ageing Research, Arenaza-Urquijo, Eider, André, Claire, Botton, Maelle, Cantou, Pauline, Chételat, Gaëlle, Chocat, Anne, De la Sayette, Vincent, Delarue, Marion, Egret, Stéphanie, Ferrand Devouge, Eglantine, Frison, Eric, Gonneaud, Julie, Heidmann, Marc, Kuhn, Elizabeth, Landeau, Brigitte, Le Du, Gwendoline, Lefranc, Valérie, Mezenge, Florence, Moulinet, Inès, Ourry, Valentin, Poisnel, Géraldine, Quillard, Anne, Rauchs, Géraldine, Rehel, Stéphane, Tomadesso, Clémence, Touron, Edelweiss, Ware, Caitlin, and Wirth, Miranka
- Subjects
Aging ,Brain Mapping ,Emotions ,Neuroscience (miscellaneous) ,Humans ,ddc:610 ,diagnostic imaging [Amygdala] ,Geriatrics and Gerontology ,diagnostic imaging [Brain] ,Magnetic Resonance Imaging ,Aged - Abstract
Basic emotional functions seem well preserved in older adults. However, their reactivity to and recovery from socially negative events remain poorly characterized. To address this, we designed a 'task-rest' paradigm in which 182 participants from two independent experiments underwent functional magnetic resonance imaging while exposed to socio-emotional videos. Experiment 1 (N = 55) validated the task in young and older participants and unveiled age-dependent effects on brain activity and connectivity that predominated in resting periods after (rather than during) negative social scenes. Crucially, emotional elicitation potentiated subsequent resting-state connectivity between default mode network and amygdala exclusively in older adults. Experiment 2 replicated these results in a large older adult cohort (N = 127) and additionally showed that emotion-driven changes in posterior default mode network-amygdala connectivity were associated with anxiety, rumination and negative thoughts. These findings uncover the neural dynamics of empathy-related functions in older adults and help understand its relationship to poor social stress recovery.
- Published
- 2023
- Full Text
- View/download PDF
43. Anterior-temporal network hyperconnectivity is key to Alzheimer's disease: from ageing to dementia.
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Chauveau L, Landeau B, Dautricourt S, Turpin AL, Delarue M, Hébert O, de La Sayette V, Chételat G, and de Flores R
- Abstract
Curing Alzheimer's disease remains hampered by an incomplete understanding of its pathophysiology and progression. Exploring dysfunction in medial temporal lobe networks, particularly the anterior-temporal (AT) and posterior-medial (PM) systems, may provide key insights, as these networks exhibit functional connectivity alterations along the entire Alzheimer's continuum, potentially influencing disease propagation. However, the specific changes in each network and their clinical relevance across stages are not yet fully understood. This requires considering commonly used biomarkers, clinical progression, individual variability, and age confounds. Here, we leveraged monocentric longitudinal data from 261 participants spanning the adult lifespan and the Alzheimer's continuum. The sample included cognitively unimpaired adults aged 19 to 85 years (n = 209; eight out of 64 older adults over 60 were Aβ-positive) and Aβ-positive patients fulfilling diagnostic criteria for mild cognitive impairment (MCI, n = 26; 18 progressed to Alzheimer-dementia within seven years) or Alzheimer's type dementia (n = 26). Participants underwent structural and resting-state functional (f) MRI, florbetapir and FDG-PET, and global cognitive assessments, with up to three visits over a maximum period of 47 months. Network connectivity was assessed using seed-based analyses with the perirhinal and parahippocampal cortices as seeds, within data-driven masks reflecting the AT and PM networks. Generalized additive and linear mixed models were run to assess age-specific effects and Alzheimer's-related alterations. In this context, we explored various markers of pathological and clinical severity, including cerebral amyloid uptake, glucose metabolism, hippocampal volume, global cognition, diagnostic staging, and time to dementia onset. Our findings revealed distinct patterns of connectivity linked to normal aging or Alzheimer's disease. Advancing age throughout adulthood was associated with lower PM connectivity and more subtle changes in AT connectivity, while Alzheimer's disease was characterised by AT hyperconnectivity without global changes in PM connectivity. Specifically, AT connectivity was higher in MCI and Alzheimer-dementia patients compared to older controls and was positively associated with amyloid burden, glucose hypometabolism, hippocampal atrophy, and global cognitive deficits in older adults, ranging from unimpaired to demented. Additionally, higher AT connectivity correlated with faster progression to Alzheimer-dementia in MCI patients. This comprehensive approach allowed to reveal that excessive connectivity within the AT network is intrinsically linked to the pathological and clinical progression of Alzheimer's disease. These insights may guide future research to better understand cascading events leading to the disease and hold promise for developing prognostic tools and therapeutic interventions targeting these specific network alterations., (© The Author(s) 2025. Published by Oxford University Press on behalf of the Guarantors of Brain.)
- Published
- 2025
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44. Effect of cognitive reserve on the association between slow wave sleep and cognition in community-dwelling older adults.
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Ourry V, Rehel S, André C, Mary A, Paly L, Delarue M, Requier F, Hendy A, Collette F, Marchant NL, Felisatti F, Palix C, Vivien D, de la Sayette V, Chételat G, Gonneaud J, and Rauchs G
- Subjects
- Aged, Humans, Cognition, Independent Living, Neuropsychological Tests, Sleep, Cognitive Reserve, Sleep, Slow-Wave
- Abstract
Sleep, especially slow wave sleep (SWS), is essential for cognitive functioning and is reduced in aging. The impact of sleep quality on cognition is variable, especially in aging. Cognitive reserve (CR) may be an important modulator of these effects. We aimed at investigating this question to better identify individuals in whom sleep disturbances might have greater behavioral consequences. Polysomnography and neuropsychological assessments were performed in 135 cognitively intact older adults (mean age ± SD: 69.4 ± 3.8y) from the Age-Well randomized controlled trial (baseline data). Two measures of cognitive engagement throughout life were used as CR proxies. Linear regression analyses were performed between the proportion of SWS, and executive function and episodic memory composite scores. Then, interaction analyses between SWS and CR proxies on cognition were conducted to assess the possible impact of CR on these links. SWS was positively associated with episodic memory, but not with executive function. CR proxies modulated the associations between SWS and both executive and episodic memory performance. Specifically, individuals with higher CR were able to maintain cognitive performance despite low amounts of SWS. This study provides the first evidence that CR may protect against the deleterious effects of age-related sleep changes on cognition.
- Published
- 2023
- Full Text
- View/download PDF
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