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1. Thrombotic events.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Major thrombotic complications in myeloproliferative neoplasms (MPNs) represent an important clinical problem due to their high morbidity, the complexity of their management, and their associated mortality. The appearance of a thrombosis implies a high thrombotic risk stratification of the MPN and determines the initiation or optimization of cytoreductive treatment and the use of antiplatelet or anticoagulant therapy as secondary prophylaxis. The incidence of thrombosis at the time of diagnosis is higher than during the course of the disease, being located in the arterial territory in 60-70% of cases. Once thrombosis has occurred, up to 20-33% of patients experience thrombotic recurrence in the same initial vascular territory., (Copyright: © 2022 Permanyer.)

Published
2022
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2. Risks in invasive procedures.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Luis Álvarez-Vera J, Rojas-Castillejos F, Peñaloza-Ramírez R, Alejandro Carballo-Zarate A, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Patients with myeloproliferative neoplasms have an increased risk of thrombosis and bleeding. This risk must be identified, as well as individualizing the therapeutic strategy before invasive procedures; adequate cytoreduction reduces the risk of complications., (Copyright: © 2022 Permanyer.)

Published
2022
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3. Transplantation of hematopoietic progenitors in myelofibrosis.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, Luis López-Arroyo J, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

The objective of this work is to generate recommendations on the management of allogeneic stem cell transplantation (allo-SCT) in primary myelofibrosis (PMF). A comprehensive systematic review of articles published between 1999 and 2015 (January) was used as a source of scientific evidence. The recommendations were produced through a Delphi process involving a panel of 23 experts appointed by the European LeukemiaNet and the European Blood and Marrow Transplantation Group. Key questions included patient selection, donor selection, pre-transplant management, conditioning regimen, post-transplant management, prevention, and management of post-transplant relapse. Patients with intermediate-2 or high-risk disease and age < 70 years should be considered candidates for allo-SCT. Patients with intermediate-risk 1 disease and age < 65 years should be considered candidates if they have refractory transfusion-dependent anemia, or a peripheral blood (PB) blast percentage > 2%, or adverse cytogenetics. Splenectomy before transplantation must be decided on a case-by-case basis. Patients with intermediate-2 or high-risk disease who lack a human leukocyte antigen (HLA)-matched sibling or unrelated donor should be enrolled in a protocol that uses HLA non-identical donors. PB was considered the most appropriate source of hematopoietic stem cells for transplants from HLA-matched unrelated donors and siblings. The optimal intensity of the conditioning regimen has yet to be defined. Strategies such as discontinuation of immunosuppressive drugs, infusion of donor lymphocytes, or both were considered adequate to prevent clinical relapse. In conclusion, we provide consensus-based recommendations aimed at optimizing allo-SCT in PMF. Unmet clinical needs were highlighted., (Copyright: © 2022 Permanyer.)

Published
2022
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4. Pregnancy in myeloproliferative neoplasms.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Myeloproliferative neoplasms (MPN) are associated with a significant risk of thrombosis and the hypercoagulable environment of pregnancy increases this risk. The most frequent gestational complications consist of spontaneous abortion, thrombosis, bleeding, and hypertensive disease of pregnancy. Treatment depends on thrombotic risk, gestational trimester, and myeloproliferative neoplasm., (Copyright: © 2022 Permanyer.)

Published
2022
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5. Polycythemia vera.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Gissell Aguirre-Reyes O, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Alberto Bates-Martín R, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Ángeles Rosales-López ML, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Polycythemia vera (PV) is mainly characterized by erythrocytosis, thrombotic and hemorrhagic predisposition, a variety of symptoms, and cumulative risks of fibrotic progression and/or leukemic evolution over time. The diagnosis is made based on the 2016 WHO criteria. The treatment of PV focuses on rapidly reducing the erythrocyte mass, either by means of phlebotomies or with cytoreductive treatment, and the reduction of thrombotic risk by correcting cardiovascular risk factors and the use of platelet antiaggregants., (Copyright: © 2022 Permanyer.)

Published
2022
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6. Symptom control.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

In addition to symptoms secondary to splenomegaly, microvascular abnormalities, and thrombohemorrhagic complications, patients with MPN may experience a significant symptom burden attributed to an increase in circulating inflammatory cytokines. These symptoms can be severe and limit quality of life. Therefore, in addition to the prevention of complications, one of the objectives of the treatment of MPN is the control of symptoms., (Copyright: © 2022 Permanyer.)

Published
2022
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7. Essential thrombocythaemia.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Ángeles Rosales-López ML, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Essential thrombocythemia (ET) is a chronic Philadelphia-negative myeloproliferative neoplasm that has its main involvement in the megakaryopoietic lineage, generating sustained thrombocytosis in peripheral blood and an increase in the number of mature megakaryocytes in the bone marrow. In addition to marked thrombocytosis, it is characterized by increased thrombotic or hemorrhagic risk and the presence of constitutional symptoms. Patients with ET have a low but known risk of disease progression to myelofibrosis and/or acute leukemia. The diagnosis is made based on the 2016 WHO criteria. At present, available treatments for patients with ET are mainly aimed at minimizing the risk of thrombosis and/or bleeding., (Copyright: © 2022 Permanyer.)

Published
2022
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8. Myelofibrosis: diagnosis and treatment.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Álvarez-Vera JL, Rojas-Castillejos F, Peñaloza-Ramírez R, Carballo-Zarate AA, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Moralws-Hernández AE, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Jiménez-Ochoa MA, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

Myelofibrosis (MF) is a BCR-ABL1-negative myeloproliferative neoplasm characterized by clonal myeloproliferation, dysregulated kinase signaling, and release of abnormal cytokines. In recent years, important progress has been made in the knowledge of the molecular biology and the prognostic assessment of MF. Conventional treatment has limited impact on the patients' survival; it includes a wait-and-see approach for asymptomatic patients, erythropoiesis-stimulating agents, androgens, or immunomodulatory agents for anemia, cytoreductive drugs such as hydroxyurea for the splenomegaly and constitutional symptoms, and splenectomy or radiotherapy in selected patients. The discovery of the Janus kinase (JAK) 2 mutation triggered the development of molecular targeted therapy of MF. The JAK inhibitors are effective in both JAK2-positive and JAK2-negative MF; one of them, ruxolitinib, is the current best available therapy for MF splenomegaly and constitutional symptoms. Although ruxolitinib has changed the therapeutic scenario of MF, there is no clear indication of a disease-modifying effect. Allogeneic stem cell transplantation remains the only curative therapy of MF, but due to its associated morbidity and mortality, it is usually restricted to eligible high- and intermediate-2-risk MF patients. To improve current therapeutic results, the combination of JAK inhibitors with other agents is currently being tested, and newer drugs are being investigated., (Copyright: © 2022 Permanyer.)

Published
2022
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9. First inter-institutional consensus on Chronic Myeloproliferative Neoplasms.

Author

Barranco-Lampón G, Martínez-Castro R, Arana-Luna L, Luis Álvarez-Vera J, Rojas-Castillejos F, Peñaloza-Ramírez R, Alejandro Carballo-Zarate A, Olarte-Carrillo I, Minamy JI, López-Salazar J, Navarrete JJ, Espinosa-Partida A, Ventura-Enríquez Y, Ruiz-Contreras JI, Aguirre-Reyes OG, Anaya-Cuéllar I, Aguilar-Luévano J, Díaz-Ramírez HF, Herrera-Olivares W, Aguilar-Hidalgo JA, Alcívar-Cedeño LM, Hernández-Caballero Á, Galaz-Cordero LE, Peña-Celaya JA, Báez-Islas PE, Bates-Martín RA, Cano-León AML, Espitia-Ríos ME, Barbosa D, Morales-Adrián J, Pacheco MJ, Delgado-López N, Neme-Yunes Y, Edna Moralws-Hernández A, Mújica-Martínez A, Pérez-Lizardi AB, Pérez-Gómez KD, Barragán-Ibáñez G, Martínez A, Flores-Ordúñez K, Ramírez-Hoyos P, Rosales-López MLÁ, Acosta-Maldonado BL, Alejandro Jiménez-Ochoa M, Garzón-Velásquez KB, Hernández-Ruiz E, McNally-Guillén BM, Saucedo-Montes EE, Aguilar-Andrade C, Vivas-Arteaga CL, Guerra-Alarcón LV, Milán-Salvatierra AI, Campa-Monroy DI, Cota-Rangel X, Estrada-Domínguez P, García-Camacho AS, García-Castillo C, Banda-García LI, Rodríguez-Sánchez V, Meillón-García LA, Urbina-Escalante E, Martínez-Ramírez MA, Loera-Fragoso SJ, Martínez-Coronel J, Zapata-Canto N, Gómez-Cortés SC, Medina-Coral JE, Mójica-Balderas L, Pérez-Zúñiga JM, Pérez FJ, López-Arroyo JL, Zazueta-Pozos JF, Romero-Martínez E, Romero-Rodelo H, Tapia-Enríquez AL, Soriano-Mercedes EJ, Salazar-Ramírez Ó, Vilchis-González SP, Tepepa-Flores F, and Alvarado-Ibarra M

Abstract

The objective of the consensus is to make available to the professionals of the different public health institutions in our country, who are in charge of these diseases, the most relevant and up-to-date information about their diagnosis and treatment in clinical practice. With this inter-institutional consensus we hope to contribute to improving the quality of care for patients with chronic myeloproliferative neoplasms throughout the Mexican Republic, to unify criteria in both diagnosis and treatment of the different myeloproliferative diseases., (Copyright: © 2022 Permanyer.)

Published
2022
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10. Treating Acute Leukemia During the COVID-19 Pandemic in an Environment With Limited Resources: A Multicenter Experience in Four Latin American Countries.

Author

Demichelis-Gómez R, Alvarado-Ibarra M, Vasquez-Chávez J, Delgado-López N, Gómez-Cortés C, Espinosa-Bautista K, Cooke-Tapia A, Milán-Salvatierra A, Gómez-De León A, Lee-Tsai YL, Rosales-López D, Cabrera-García Á, Amador-Medina F, Córdoba-Ramírez A, Murrieta-Álvarez I, Solís-Poblano JC, Apodaca-Chávez E, Rangel-Patiño J, Álvarez-Vera JL, Arana-Luna L, De la Peña-Celaya JA, Espitia-Ríos ME, Hernández-Ruiz E, Pérez-Zúñiga JM, Peña-López E, González-Rivera R, García-Leyva MF, Tejeda-Romero M, Cruz-Rico J, Balderas-Delgado C, Ruíz-Argüelles GJ, and Gómez-Almaguer D

Subjects
Acute Disease, Adolescent, Adult, Aged, Aged, 80 and over, COVID-19 epidemiology, COVID-19 virology, Comorbidity, Epidemics, Female, Guatemala epidemiology, Humans, Leukemia, Myeloid diagnosis, Leukemia, Myeloid epidemiology, Male, Mexico epidemiology, Middle Aged, Panama epidemiology, Peru epidemiology, Prospective Studies, SARS-CoV-2 physiology, Young Adult, COVID-19 prevention & control, Leukemia, Myeloid therapy, Medical Oncology methods, SARS-CoV-2 isolation & purification
Abstract

Purpose: The COVID-19 pandemic is a colossal challenge for global health; nonetheless, specific subgroups face considerably higher risks for infection and mortality. Among patients with malignant diseases, those with hematologic neoplasms are at a higher risk for poor outcomes. The objective of this study was to register treatment modifications associated with the COVID-19 pandemic and their short-term consequences in Latin America., Methods: Multicenter, prospective, observational, cohort study including patients older than 14 years from 14 centers in four countries (Mexico, Peru, Guatemala, and Panama) who had a confirmed diagnosis of acute leukemia, and who were undergoing active treatment since the first COVID-19 case in each country until the cutoff on July 15, 2020., Results: We recruited 635 patients. Treatment modifications because of the COVID-19 pandemic were reported in 40.8% of cases. The main reason for such modifications was logistic issues (55.0%) and the most frequent modification was chemotherapy delay (42.0%). A total of 13.1% patients developed COVID-19 disease, with a mortality of 37.7%. Several factors were identified as independently associated with mortality, including a diagnosis of acute myeloid leukemia (odds ratio 2.38 [95% CI, 1.47 to 3.84]; P < .001), while the use of telemedicine was identified as a protective factor (odds ratio 0.36 [95% CI, 0.18 to 0.82]; P = .014)., Conclusion: These results highlight the collateral damage of COVID-19 in oncology patients., Competing Interests: Roberta Demichelis-GómezHonoraria: AbbVie, Novartis, Amgen, Celgene/Bristol-Myers SquibbConsulting or Advisory Role: AbbVie, Novartis, Amgen, Celgene/Bristol-Myers Squibb, Jazz PharmaceuticalsSpeakers' Bureau: AbbVie, Novartis, Amgen, Celgene/Bristol-Myers SquibbResearch Funding: NovartisTravel, Accommodations, Expenses: AbbVie, Novartis Jule Vasquez-ChávezTravel, Accommodations, Expenses: Janssen Nancy Delgado-LópezConsulting or Advisory Role: Amgen, PfizerSpeakers' Bureau: Bristol-Myers Squibb (Mexico), Novartis Ana Cooke-TapiaTravel, Accommodations, Expenses: Janssen Andrés Gómez-De LeónHonoraria: Novartis, AbbVieConsulting or Advisory Role: AstraZeneca, Sanofi/Aventis Luara Arana-LunaSpeakers' Bureau: Amgen, NovartisTravel, Accommodations, Expenses: Teva José Antonio De la Peña-CelayaConsulting or Advisory Role: Janssen-Cilag, RocheSpeakers' Bureau: Janssen-Cilag, Roche, Novartis, Asofarma, Celgene/Bristol-Myers SquibbTravel, Accommodations, Expenses: Roche Eleazar Hernández-RuizSpeakers' Bureau: RocheResearch Funding: Bristol-Myers Squibb, Amgen, Roche Juan Manuel Pérez-ZúñigaConsulting or Advisory Role: Roche, Takeda, Bayer, Sanofi, Novo NordiskSpeakers' Bureau: Roche, Bristol-Myers Squibb (Mexico), Novartis, AmgenResearch Funding: AstraZeneca David Gómez-AlmaguerConsulting or Advisory Role: Celgene, Janssen, TakedaSpeakers' Bureau: Bristol-Myers Squibb (Mexico), AbbVie, Novartis, Janssen, AmgenNo other potential conflicts of interest were reported.

Published
2021
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11. [Acute myeloblastic leukemia (M5) and aspergilloma in a 75-year-old man].

Author

Delgado-López N, Nacho-Vargas KA, Terreros-Muñoz E, and Meillón-García LA

Subjects
Aged, Aspergillosis diagnosis, Aspergillosis therapy, Humans, Leukemia, Myeloid, Acute diagnosis, Leukemia, Myeloid, Acute therapy, Lung Diseases, Fungal diagnosis, Lung Diseases, Fungal therapy, Male, Aspergillosis complications, Leukemia, Myeloid, Acute complications, Lung Diseases, Fungal complications
Abstract

We report here a case of pulmonary aspergilloma in a patient with acute myeloblastic leukemia. We present the clinical and radiological characteristics of this case. Aspergillus flavus was isolated. The antifungal treatment was unsuccessful. Pulmonary aspergillomas are associated with a high mortality in the immunocompromised host. It is important to know the diagnostic approach and the surgical and medical treatment of this disease.

Published
2004

12. [West Nile fever].

Author

Delgado-López N, Andrade-Zárate V, Nellen-Hummel H, and Halabe-Cherem J

Subjects
Humans, West Nile Fever diagnosis, West Nile Fever epidemiology, West Nile Fever therapy
Abstract

West Nile fever is a mosquito-borne febrile illness seen in Africa, Asia, and Europe, but reported in North America only once. West Nile virus is of the family Flaviviridae, genus Flavivirus. Several West Nile fever outbreaks were reported from Israel in the 1950s and in 1980. Since the mid-1990s, frequency and apparent clinical severity of West Nile virus outbreaks have increased. Outbreaks in Rumania (1996), Russia (1999), and Israel (2000) involved hundreds of persons with severe neurologic disease. In the summer of 1999, West Nile virus was recognized in the among Western Hemisphere for the first time when it caused an epidemic of encephalitis and aseptic meningitis among residents of greater New York City. Other outbreak occurred during the summer of 2000. West Nile fever in humans usually is a febrile, influenza-like illness characterized by abrupt onset. Occasionally (less than 15% of cases) are acute aseptic meningitis or encephalitis. Although human vaccines for West Nile virus are under development, the most effective to way reduce local population of mosquitoes is to eliminate sources of standing water and preventing vector mosquitoes from biting humans by using mosquito repellents and barrier methods.

Published
2003

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