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1. A novel Hemi-Body Irradiation technique using electron beams (HBIe(-))

Author

Delinikolas, Panagiotis Patatoukas, Georgios Kouloulias, Vasilios Dilvoi, Maria Plousi, Agapi Efstathopoulos, Efstathios Platoni, Kalliopi

Abstract

Purpose: Certain radiation responsive skin diseases may develop symptoms on the upper or the lower half of the body. The concept of a novel Hemi-Body Electron Irradiation (HBIe(-)) technique, described in this work, provides a low cost, LINAC based, intermediate treatment option in between extremely localized and Total Skin irradiation techniques. Materials and methods: The HBIe(-) technique, developed in our department, incorporates a custom crafted treatment chamber equipped with adjustable Pb shielding and a single electron beam in extended Source-Skin Distance (SSD) setup. The patient is positioned in ‘Stanford’ technique positions. The geometrical setup provides both optimal dose homogeneity and dose deposition up to a depth of 2 cm. To confirm this, the following characteristics were measured and evaluated: a) percentage depth dose (PDD) on the treatment plane produced by a single electron beam at perpendicular incidence for six fields at ‘Stanford’ angles, b) 2D profile of the entrance dose on the treatment plane produced by a single field and c) the total surface dose on an anthropomorphic phantom delivered by all 6 fields. Results: The resulting homogeneity of the surface dose in the treatment plane for an average patient was 5-6%, while surface dose homogeneity on the anthropomorphic phantom was 7% for both the upper and the lower HBIe(-) variants. The total PDD exhibits an almost linear decrease to a practical range of 2 g/cm(2). Conclusion: In conclusion, HBIe(-) was proven effective in delivering the prescribed dose to the target area, while protecting the healthy skin.

Published
2018

2. HORIZON 2020 EuPRAXIA Design Study

Author

Walker, Paul Andreas, Alesini, David, Alexandrova, Alexandra, Anania, Maria Pia, Andreev, Nikolay, Assmann, Ralph, Audet, Thomas, Bacci, Alberto, Barna, Imre, Beaton, Andrew, Beck, Arnaud, Beluze, Audrey, Bernhard, Axel, Bielawski, Serge, Bisesto, Fabrizio, Bödewadt, Joern, Brandi, Fernando, Bringer, Olivier, Brinkmann, Reinhard, Bründermann, Erik, Bussolino, Giancarlo, Buescher, Markus, Chancé, Antoine, Chen, Min, Chiadroni, Enrica, Cianchi, Alessandro, Clarke, James, Couprie, Marie-Emmanuelle, Croia, Michele, Cros, Brigitte, Dale, John, Dattoli, Giuseppe, Delerue, Nicolas, Delferrière, Olivier, Delinikolas, Panagiotis, Dias, João, Dorda, Ulrich, Ertel, Klaus, Ferran Pousa, Ángel, Ferrario, Massimo, Filippi, Francesco, Fils, Jérôme, Fiorito, Ralph, Fonseca, Ricardo, Galimberti, Marco, Gallo, Alessandro, Garzella, David, Gastinel, Philippe, Giove, Dario, Giribono, Anna, Gizzi, Leonida, Grüner, Florian, Habib, A. Fahim, Haefner, Leon, Heinemann, Thomas, Hidding, Bernhard, Holzer, Bernhard, Hooker, Simon, Hosokai, Tomonao, Jaroszynski, Dino, Joshi, Chan, Kaluza, Malte, Karger, Oliver, Karsch, Stefan, Khazanov, Efim, Khikhlukha, Danila, Knetsch, Alexander, Kocon, Dariusz, Koester, Petra, Kononenko, Olena, Korn, Georg, Kostyukov, Igor, Labate, Luca, Lechner, Christoph, Leemans, Wim, Lehrach, Andreas, Li, Fei Yu, Li, Xiangkun, Lifschitz, Agustin, Litvinenko, Vladimir, Lu, Wei, Maier, Andreas, Malka, Victor, Manahan, Grace, Mangles, Stuart, Marchetti, Barbara, Marocchino, Alberto, Martinez de La Ossa, Alberto, Martins, Joana, Masaki, Kando, Massimo, Francesco, Mathieu, Francois, Maynard, Gilles, Mehrling, Timon, Molodozhentsev, Alexander, Mosnier, Alban, Mostacci, Andrea, Müller, Anke-Susanne, Najmudin, Zulfikar, Nghiem, Phu Anh Phi, Nguyen, Federico, Niknejadi, Pardis, Osterhoff, Jens, Papadopoulos, Dimitrios, Patrizi, Barbara, Pattathil, Rajeev, Petrillo, Vittoria, Pocsai, Mihály, Poder, Kristjan, Pompili, Riccardo, Pribyl, Lukas, Pugacheva, Daria, Romeo, Stefano, Rossi, Andrea, Sahai, Aakash, Sano, Yoshinobu, Scherkl, Paul, Schramm, Ulrich, Schroeder, Carl, Schwindling, Jerome, Scifo, Jessica, Serafini, Luca, Sheng, Zhengming, Silva, Luis, Simon, Claire, Sinha, Ujjwal, Specka, Arnd, Streeter, Matthew, Svystun, Elena, Symes, Daniel, Szwaj, Christophe, Tauscher, Gabriele, Thomas, Alec, Thompson, Neil, Toci, Guido, Tomassini, Paolo, Vaccarezza, Cristina, Vannini, Matteo, Vieira, Jorge, Villa, Fabio, Wahlstrom, Claes-Goran, Walczak, Roman, Weikum, Maria, Welsch, Carsten, Wolfenden, Joseph, Xia, Guoxing, Yabashi, Makina, Yu, Lule, Zhu, Jun, Zigler, Arie, Laboratoire de physique des gaz et des plasmas (LPGP), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire pour l'utilisation des lasers intenses (LULI), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 (PhLAM), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Synchrotron SOLEIL (SSOLEIL), Centre National de la Recherche Scientifique (CNRS), Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'optique appliquée (LOA), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-École Nationale Supérieure de Techniques Avancées (ENSTA Paris), Laboratoire de Physique des Plasmas (LPP), Université Paris-Sud - Paris 11 (UP11)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École polytechnique (X)-Sorbonne Université (SU)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Institut du Cerveau et de la Moëlle Epinière = Brain and Spine Institute (ICM), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-École polytechnique (X)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Joint Global Change Research Institute, Pacific Northwest National Laboratory (PNNL)-University of Maryland [College Park], University of Maryland System-University of Maryland System, École Nationale Supérieure de Techniques Avancées (ENSTA Paris)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11)

Subjects
radiation, electron, [PHYS.PHYS.PHYS-ACC-PH]Physics [physics]/Physics [physics]/Accelerator Physics [physics.acc-ph], Physics::Accelerator Physics, acceleration, Accelerators and Storage Rings, plasma, laser
Abstract

International audience; The Horizon 2020 Project EuPRAXIA ('European Plasma Research Accelerator with eXcellence In Applications') aims at producing a design report of a highly compact and cost-effective European facility with multi-GeV electron beams using plasma as the acceleration medium. The accelerator facility will be based on a laser and/or a beam driven plasma acceleration approach and will be used for photon science, high-energy physics (HEP) detector tests, and other applications such as compact X-ray sources for medical imaging or material processing. EuPRAXIA started in November 2015 and will deliver the design report in October 2019. EuPRAXIA aims to be included on the ESFRI roadmap in 2020.

Published
2017

4. Angled laser triggered electron injection in the electron driven plasma wakefield acceleration scheme : a case study in a pursuit to increase tolerance levels, based on FACET II driver parameters

Author

Delinikolas, Panagiotis, Manahan, Grace, Hidding, Bernhard, Beaton, Andrew, Scherkl, Paul, Karger, Oliver, Witting, Georg, Knetsch, Alexander, Heinemann, Thomas, Hurtig, Gregor, and Habib, Fahim

Subjects
QC
Abstract

Co-axial laser triggered injection of electrons in PWFA can produce high quality witness bunches. In this study, angled injection was examined in a pursuit to increase the tolerance levels of synchronization and experimental misalignments while maintaining the high quality of the witness bunches.

Published
2016

5. HORIZON 2020 EuPRAXIA Design Study

Author

Walker, Paul Andreas, Alesini, David, Alexandrova, Alexandra, Anania, Maria Pia, Andreev, Nikolay, Aßmann, Ralph, Audet, Thomas, Bacci, Alberto, Barna, Imre, Beaton, Andrew, Beck, Arnaud, Beluze, Audrey, Bernhard, Axel, Bielawski, Serge, Bisesto, Fabrizio, Bödewadt, Joern, Brandi, Fernando, Bringer, Olivier, Brinkmann, Reinhard, Bründermann, Erik, Bussolino, GianCarlo, Büscher, Markus, Chancé, Antoine, Chen, Min, Chiadroni, Enrica, Cianchi, Alessandro, Clarke, James, Couprie, Marie-Emmanuelle, Croia, Michele, Cros, Brigitte, Dale, John, Dattoli, Giuseppe, Delerue, Nicolas, Delferrière, Olivier, Delinikolas, Panagiotis, Dias, JoãO, Dorda, Ulrich, Ertel, Klaus, Ferran Pousa, ÁNgel, Ferrario, Massimo, Filippi, Francesco, Fils, JéRôMe, Fiorito, Ralph, Fonseca, Ricardo, Galimberti, Marco, Gallo, Alessandro, Garzella, David, Gastinel, Philippe, Giove, Dario, Giribono, Anna, Gizzi, Leonida, Grüner, Florian, Habib, A. Fahim, Haefner, Leon, Heinemann, Thomas, Hidding, Bernhard, Holzer, Bernhard, Hooker, Simon, Hosokai, Tomonao, Jaroszynski, Dino, Joshi, Chan, Kaluza, Malte, Karger, Oliver, Karsch, Stefan, Khazanov, Efim, Khikhlukha, Danila, Knetsch, Alexander, Kocon, Dariusz, Koester, Petra, Kononenko, Olena, Korn, Georg, Kostyukov, Igor, Labate, Luca, Lechner, Christoph, Leemans, Wim, Lehrach, Andreas, Li, Fei Yu, Li, Xiangkun, Lifschitz, Agustin, Litvinenko, Vladimir, Lu, Wei, Maier, Andreas, Malka, Victor, Manahan, Grace, Mangles, Stuart, Marchetti, Barbara, Marocchino, Alberto, Martinez De La Ossa, Alberto, Martins, Joana, Masaki, Kando, Massimo, Francesco, Mathieu, Francois, Maynard, Gilles, Mehrling, Timon, Molodozhentsev, Alexander, Mosnier, Alban, Mostacci, Andrea, Müller, Anke-Susanne, Najmudin, Zulfikar, Nghiem, Phu Anh Phi, Nguyen, Federico, Niknejadi, Pardis, Osterhoff, Jens, Papadopoulos, Dimitrios, Patrizi, Barbara, Pattathil, Rajeev, Petrillo, Vittoria, Pocsai, MiháLy, Poder, Kristjan, Pompili, Riccardo, Pribyl, Lukas, Pugacheva, Daria, Romeo, Stefano, Rossi, Andrea, Sahai, Aakash, Sano, Yoshinobu, Scherkl, Paul, Schramm, Ulrich, Schroeder, Carl, Schwindling, Jerome, Scifo, Jessica, Serafini, Luca, Sheng, Zhengming, Silva, Luis, Simon, Claire, Sinha, Ujjwal, Specka, Arnd, Streeter, Matthew, Svystun, Elena, Symes, Daniel, Szwaj, Christophe, Tauscher, Gabriele, Thomas, Alec, Thompson, Neil, Toci, Guido, Tomassini, Paolo, Vaccarezza, Cristina, Vannini, Matteo, Vieira, Jorge, Villa, Fabio, Wahlstrom, Claes-Goran, Walczak, Roman, Weikum, Maria, Welsch, Carsten, Wolfenden, Joseph, Xia, Guoxing, Yabashi, Makina, Yu, Lule, Zhu, Jun, and Zigler, Arie

Subjects
03 Novel Particle Sources and Acceleration Techniques, Physics::Accelerator Physics, 7. Clean energy, Accelerator Physics
Abstract

The Horizon 2020 Project EuPRAXIA ('European Plasma Research Accelerator with eXcellence In Applications') aims at producing a design report of a highly compact and cost-effective European facility with multi-GeV electron beams using plasma as the acceleration medium. The accelerator facility will be based on a laser and/or a beam driven plasma acceleration approach and will be used for photon science, high-energy physics (HEP) detector tests, and other applications such as compact X-ray sources for medical imaging or material processing. EuPRAXIA started in November 2015 and will deliver the design report in October 2019. EuPRAXIA aims to be included on the ESFRI roadmap in 2020., Proceedings of the 8th Int. Particle Accelerator Conf., IPAC2017, Copenhagen, Denmark

6. HORIZON 2020 EuPRAXIA Design Study

Author

Walker, Paul Andreas, Alesini, David, Alexandrova, Alexandra, Anania, Maria Pia, Andreev, Nikolay, Aßmann, Ralph, Audet, Thomas, Bacci, Alberto, Barna, Imre, Beaton, Andrew, Beck, Arnaud, Beluze, Audrey, Bernhard, Axel, Bielawski, Serge, Bisesto, Fabrizio, Bödewadt, Joern, Brandi, Fernando, Bringer, Olivier, Brinkmann, Reinhard, Bründermann, Erik, Bussolino, GianCarlo, Büscher, Markus, Chancé, Antoine, Chen, Min, Chiadroni, Enrica, Cianchi, Alessandro, Clarke, James, Couprie, Marie-Emmanuelle, Croia, Michele, Cros, Brigitte, Dale, John, Dattoli, Giuseppe, Delerue, Nicolas, Delferrière, Olivier, Delinikolas, Panagiotis, Dias, J. M., Dorda, Ulrich, Ertel, Klaus, Ferran Pousa, Angel, Ferrario, Massimo, Filippi, Francesco, Fils, J., Fiorito, Ralph, Fonseca, Ricardo, Galimberti, Marco, Gallo, Alessandro, Garzella, David, Gastinel, Philippe, Giove, Dario, Giribono, Anna, Gizzi, Leonida, Grüner, Florian, Habib, A. Fahim, Haefner, Leon, Heinemann, Thomas, Hidding, Bernhard, Holzer, Bernhard, Hooker, Simon, Hosokai, Tomonao, Jaroszynski, Dino, Joshi, Chan, Kaluza, Malte, Karger, Oliver, Karsch, Stefan, Khazanov, Efim, Khikhlukha, Danila, Knetsch, Alexander, Kocon, Dariusz, Koester, Petra, Kononenko, Olena, Korn, Georg, Kostyukov, Igor, Labate, Luca, Lechner, Christoph, Leemans, Wim, Lehrach, Andreas, Li, Fei Yu, Li, Xiangkun, Lifschitz, Agustin, Litvinenko, Vladimir, Lu, Wei, Maier, Andreas, Malka, Victor, Manahan, Grace, Mangles, Stuart, Marchetti, Barbara, Marocchino, Alberto, Martinez De La Ossa, Alberto, Martins, Joana, Masaki, Kando, Massimo, Francesco, Mathieu, Francois, Maynard, Gilles, Mehrling, Timon, Molodozhentsev, Alexander, Mosnier, Alban, Mostacci, Andrea, Müller, Anke-Susanne, Najmudin, Zulfikar, Nghiem, Phu Anh Phi, Nguyen, Federico, Niknejadi, Pardis, Osterhoff, Jens, Papadopoulos, Dimitrios, Patrizi, Barbara, Pattathil, Rajeev, Petrillo, Vittoria, Pocsai, M. A., Poder, Kristjan, Pompili, Riccardo, Pribyl, Lukas, Pugacheva, Daria, Romeo, Stefano, Rossi, Andrea, Sahai, Aakash, Sano, Yoshinobu, Scherkl, Paul, Schramm, Ulrich, Schroeder, Carl, Schwindling, Jerome, Scifo, Jessica, Serafini, Luca, Sheng, Zhengming, Silva, Luis, Simon, Claire, Sinha, Ujjwal, Specka, Arnd, Streeter, Matthew, Svystun, Elena, Symes, Daniel, Szwaj, Christophe, Tauscher, Gabriele, Thomas, Alec, Thompson, Neil, Toci, Guido, Tomassini, Paolo, Vaccarezza, Cristina, Vannini, Matteo, Vieira, Jorge, Villa, Fabio, Wahlstrom, Claes-Goran, Walczak, Roman, Weikum, Maria, Welsch, Carsten, Wolfenden, Joseph, Xia, Guoxing, Yabashi, Makina, Yu, Lule, Zhu, Jun, and Zigler, Arie

Subjects
7. Clean energy
Abstract

[Proceedings of the 8th International Particle Accelerator Conference : IPAC2017 14 - 19 May 2017, Bella Center, Copenhagen, Denmark]Editors: Volker RW Schaa (GSI, Darmstadt, Germany); Gianluigi Arduini (CERN, Geneva, Switzerland); Juliana Pranke (ESS, Lund, Sweden); Mike Seidel (PSI, Villigen, Switzerland); Mats Lindroos (ESS, Lund, Sweden) 8th International Particle Accelerator Conference, IPAC2017, Copenhagen, Denmark, 14 May 2017 - 19 May 2017 ; Geneva, Switzerland : JACoW, 1265-1268(2017). doi:10.18429/JACoW-IPAC2017-TUOBB3, Published by JACoW, Geneva, Switzerland

7. First application of hemi-body electron beam irradiation for Kaposi sarcoma at the lower extremities.

Author

Platoni K, Diamantopoulos S, Dilvoi M, Delinikolas P, Kypraiou E, Efstathopoulos E, and Kouloulias V

Subjects
Humans, Lower Extremity pathology, Lower Extremity radiation effects, Male, Middle Aged, Sarcoma, Kaposi pathology, Tomography, X-Ray Computed instrumentation, Sarcoma, Kaposi radiotherapy, Tomography, X-Ray Computed methods
Abstract

Kaposi's sarcoma (KS) is a systemic neoplastic disease that can present cutaneous symptoms and is usually treated with a systematic approach due to its extent. Due to its radiosensitivity, radiotherapy is considered one of its main treatments, for palliation and local control of the skin and mucosal lesions. The aim of this paper was to report the first case of KS treated by hemi-body electron irradiation protocol in Greece. A fractionated 40 Gy hemi-body electron irradiation was prescribed to a 60-year-old male patient with KS at his legs. Dose uniformity was verified on a daily basis by thermoluminescence dosimetry (TLD). The treatment resulted to complete clinical response. Limited irradiation-derived side effects appeared. This is the first case ever to be treated with hemi-body electron irradiation protocol in Greece. To the best of our knowledge, this is also the first time that a single field hemi-body electron beam irradiation at a total skin electron beam (TSEB)-like configuration is reported to be used for KS.

Published
2018

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