20 results on '"Dello Iacono, Iride"'
Search Results
2. IgE to cross‐reactive carbohydrate determinants (CCD) in childhood: Prevalence, risk factors, putative origins.
- Author
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Potapova, Ekaterina, Tripodi, Salvatore, Panetta, Valentina, Dramburg, Stephanie, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, del Giudice, Michele Miraglia, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Moschese, Viviana, Sfika, Ifigenia, Varin, Elena, and Asero, Riccardo
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IMMUNOGLOBULIN E ,CARBOHYDRATES ,ALLERGENIC extracts ,GERMANS ,ALLERGIC conjunctivitis ,BROMELIN ,PEANUT allergy - Abstract
Background: IgE antibodies to cross‐reactive carbohydrate determinants (CCD) are usually clinically irrelevant but they can be a cause of false positive outcomes of allergen‐specific IgE tests in vitro. Their prevalence and levels have been so far cross‐sectionally examined among adult allergic patients and much less is known about their origins and relevance in childhood. Methods: We examined CCD with a cross‐sectional approach in 1263 Italian pollen allergic children (Panallergen in Paediatrics, PAN‐PED), as well as with a longitudinal approach in 612 German children (Multicenter Allergy Study, MAS), whose cutaneous and IgE sensitization profile to a broad panel of allergen extracts and molecules was already known. The presence and levels of IgE to CCD were examined in the sera of both cohorts using bromelain (MUXF3) as reagent and a novel chemiluminescence detection system, operating in a solid phase of fluorescently labelled and streptavidin‐coated paramagnetic microparticles (NOVEOS, HYCOR, USA). Results: IgE to CCD was found in 22% of the Italian pollen allergic children, mainly in association with an IgE response to grass pollen. Children with IgE to CCD had higher total IgE levels and were sensitized to more allergenic molecules of Phleum pratense than those with no IgE to CCD. Among participants of the German MAS birth cohort study, IgE to CCD emerged early in life (even at pre‐school age), with IgE sensitization to group 1 and 4 allergen molecules of grasses, and almost invariably persisted over the full observation period. Conclusions: Our results contribute to dissect the immunological origins, onset, evolution and risk factors of CCD‐sIgE response in childhood, and raise the hypothesis that group 1 and/or 4 allergen molecules of grass pollen are major inducers of these antibodies through an antigen‐specific, T‐B cell cognate interaction. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Pruritus in pediatric patients with atopic dermatitis: a multidisciplinary approach - summary document from an Italian expert group
- Author
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El Hachem, May, Di Mauro, Giuseppe, Rotunno, Roberta, Giancristoforo, Simona, De Ranieri, Cristiana, Carlevaris, Carla Maria, Verga, Maria Carmen, and Dello Iacono, Iride
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- 2020
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- View/download PDF
4. Case report: Goiter and overt hypothyroidism in an iodine-deficient toddler on soy milk and hypoallergenic diet
- Author
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Caprio, Angela Maria, primary, Umano, Giuseppina Rosaria, additional, Luongo, Caterina, additional, Aiello, Francesca, additional, Dello Iacono, Iride, additional, Palumbo, Stefania, additional, Miraglia del Giudice, Emanuele, additional, and Grandone, Anna, additional
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- 2022
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5. Complementary Feeding Caregivers’ Practices and Growth, Risk of Overweight/Obesity, and Other Non-Communicable Diseases: A Systematic Review and Meta-Analysis
- Author
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Bergamini, Marcello, primary, Simeone, Giovanni, additional, Verga, Maria Carmen, additional, Doria, Mattia, additional, Cuomo, Barbara, additional, D’Antonio, Giuseppe, additional, Dello Iacono, Iride, additional, Di Mauro, Giuseppe, additional, Leonardi, Lucia, additional, Miniello, Vito Leonardo, additional, Palma, Filomena, additional, Scotese, Immacolata, additional, Tezza, Giovanna, additional, Caroli, Margherita, additional, and Vania, Andrea, additional
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- 2022
- Full Text
- View/download PDF
6. The effect of component-resolved diagnosis on specific immunotherapy prescription in children with hay fever
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Stringari, Giovanna, Tripodi, Salvatore, Caffarelli, Carlo, Dondi, Arianna, Asero, Riccardo, Di Rienzo Businco, Andrea, Bianchi, Annamaria, Candelotti, Paolo, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, Miraglia del Giudice, Michele, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Peparini, Ilaria, Povesi Dascola, Carlotta, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Comberiati, Pasquale, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Cirisano, Anastasia, Faggian, Diego, Travaglini, Alessandro, Plebani, Mario, and Matricardi, Paolo Maria
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- 2014
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7. Timing of Complementary Feeding, Growth, and Risk of Non-Communicable Diseases: Systematic Review and Meta-Analysis
- Author
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Verga, Maria Carmen, primary, Scotese, Immacolata, additional, Bergamini, Marcello, additional, Simeone, Giovanni, additional, Cuomo, Barbara, additional, D’Antonio, Giuseppe, additional, Dello Iacono, Iride, additional, Di Mauro, Giuseppe, additional, Leonardi, Lucia, additional, Miniello, Vito Leonardo, additional, Palma, Filomena, additional, Tezza, Giovanna, additional, Vania, Andrea, additional, and Caroli, Margherita, additional
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- 2022
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8. Recommendations on Complementary Feeding as a Tool for Prevention of Non-Communicable Diseases (NCDs)—Paper Co-Drafted by the SIPPS, FIMP, SIDOHaD, and SINUPE Joint Working Group
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Caroli, Margherita, primary, Vania, Andrea, additional, Verga, Maria Carmen, additional, Di Mauro, Giuseppe, additional, Bergamini, Marcello, additional, Cuomo, Barbara, additional, D’Anna, Rosaria, additional, D’Antonio, Giuseppe, additional, Dello Iacono, Iride, additional, Dessì, Angelica, additional, Doria, Mattia, additional, Fanos, Vassilios, additional, Fiore, Michele, additional, Francavilla, Ruggiero, additional, Genovesi, Simonetta, additional, Giussani, Marco, additional, Gritti, Antonella, additional, Iafusco, Dario, additional, Leonardi, Lucia, additional, Miniello, Vito Leonardo, additional, Miraglia Del Giudice, Emanuele, additional, Palma, Filomena, additional, Pastore, Francesco, additional, Scotese, Immacolata, additional, Simeone, Giovanni, additional, Squicciarini, Marco, additional, Tezza, Giovanna, additional, Troiano, Ersilia, additional, and Umano, Giuseppina Rosa, additional
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- 2022
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9. Pollen-induced allergic rhinitis in 1360 Italian children: Comorbidities and determinants of severity
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Dondi, Arianna, Tripodi, Salvatore, Panetta, Valentina, Asero, Riccardo, Businco, Andrea Di Rienzo, Bianchi, Annamaria, Carlucci, Antonio, Ricci, Giampaolo, Bellini, Federica, Maiello, Nunzia, del Giudice, Michele Miraglia, Frediani, Tullio, Sodano, Simona, Dello Iacono, Iride, Macrì, Francesco, Massaccesi, Valerio, Caffarelli, Carlo, Rinaldi, Laura, Patria, Maria Francesca, Varin, Elena, Peroni, Diego, Chinellato, Iolanda, Chini, Loredana, Moschese, Viviana, Lucarelli, Sandra, Bernardini, Roberto, Pingitore, Giuseppe, Pelosi, Umberto, Tosca, Mariangela, Paravati, Francesco, La Grutta, Stefania, Meglio, Paolo, Calvani, Mauro, Plebani, Mario, and Matricardi, Paolo Maria
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- 2013
- Full Text
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10. CONSENSUS INTERSOCIETARIA - L’uso dei corticosteroidi inalatori in età evolutiva
- Author
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Alfaro, Carlo, Barberi, Salvatore, Becherucci, Paolo, Bergamini, Marcello, Bianchi, Anna Maria, Biasci, Paolo, Boner, Attilio, Caffarelli, Carlo, Caldarelli, Valeria, Capristo, Carlo, Capuano, Annalisa, Cardinale, Fabio, Castronuovo, Serenella, Cerimoniale, Giovanni, Chiappini, Elena, Cutrera, Renato, Castro, Giovanna, Franciscis, Luca, Decimo, Fabio, Dello Iacono, Iride, Diaferio, Lucia, Maria Di Cicco, Di Mauro, Caterina, Di Mauro, Cristina, Di Mauro, Dora, Di Mauro, Francesco, Di Mauro, Giuseppe, Doria, Mattia, Duse, Marzia, Falsaperla, Raffaele, Fanos, Vassilios, Ferraro, Valentina, Galli, Elena, Ghiglioni, Daniele Giovanni, Indinnimeo, Luciana, Kantar, Ahmad, Lamborghini, Adima, Landi, Massimo, Leonardi, Lucia, Lubrano, Riccardo, Luciani, Stefano, Macrì, Francesco, Malventano, Monica, Marseglia, Gian Luigi, Martelli, Alberto, Masini, Luigi, Midulla, Fabio, Minasi, Domenico, Miniello, Vito Leonardo, Miraglia Del Giudice, Michele, Morandini, Sergio Renzo, Nardini, Germana, Nocerino, Agostino, Novembre, Elio, Pajno, Giovanni Battista, Paravati, Francesco, Diego Peroni, Piacentini, Giorgio, Piersantelli, Cristina, Pozzobon, Gabriella, Ricci, Gian Paolo, Santamaria, Francesca, Simeone, Giovanni, Spanevello, Valter, Tezza, Giovanna, Tosca, Mariangela, Turra, Renato, Ugazio, Alberto Giovanni, Varricchio, Attilio, Verga, Maria Carmen, Zanconato, Stefania, and Zicari, Anna Maria
- Published
- 2019
11. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort.
- Author
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Cipriani, Francesca, Tripodi, Salvatore, Panetta, Valentina, Perna, Serena, Potapova, Ekaterina, Dondi, Arianna, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, Miraglia Del Giudice, Michele, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Mastrorilli, Carla, and Moschese, Viviana
- Subjects
DISEASE risk factors ,ATOPY ,LONGITUDINAL method ,BIOMARKERS ,ALLERGIC rhinitis ,HAZEL ,COHORT analysis - Abstract
Background: Pollen‐related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross‐sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large cohort of children with SAR. Methods: During 2015‐2017 (follow‐up), we re‐examined 401 patients from those enrolled in 2009‐2011 (baseline) by the "Panallergens in Pediatrics" study, a large multicenter survey of Italian children with SAR. Information on clinical history (standard questionnaire, AllergyCARD®; TPS, Italy) and skin prick tests for inhalant and foods extracts (ALK‐Abelló, Hørsholm, Denmark) was acquired as at baseline visit. Evolution in clinical and sensitization data of patients was analyzed over time, as well as their association with the main baseline characteristics and atopy risk factors. Results: The average age of participants was 10.4 ± 3.4 years at baseline and 16.2 ± 3.6 years at follow‐up. SAR persisted in 93.3% of patients at follow‐up and became more frequently associated with asthma (from 36.7% at baseline to 48.6% at follow‐up) and oral allergy syndrome (OAS, from 23.4% to 37.7%). Compared to baseline, the prevalence of skin sensitization to some pollens (Phleum pratense, Corylus avellana, Platanus acerifolia, Artemisia vulgaris) and vegetables (hazelnut, wheat, and apple) significantly decreased at follow‐up. Earlier onset of SAR and polysensitization at baseline were associated with incident asthma at follow‐up. The presence at baseline of serum IgE to the following allergen molecules was identified as biomarkers of clinical evolution: (a) Phl p 1, for persistence of SAR; (b) Phl p 5, for persistence of both rhinitis and asthma; (c) Pru p 3, for new onset of asthma; (d) Bet v 1, for persistence of OAS. Conclusions: Seasonal allergic rhinoconjunctivitis is clinically heterogeneous in its evolution from childhood to adolescence. The detection of serum IgE to specific molecules (Phl p 1, Phl p 5, Bet v 1, Pru p 3) may be useful as biomarkers to predict SAR persistence and future onset of comorbidities, such as asthma and/or OAS. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
12. Matrix effect on baked egg tolerance in children with IgE-mediated hen's egg allergy
- Author
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Miceli Sopo, Stefano, primary, Greco, Monica, additional, Cuomo, Barbara, additional, Bianchi, Annamaria, additional, Liotti, Lucia, additional, Monaco, Serena, additional, and Dello Iacono, Iride, additional
- Published
- 2016
- Full Text
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13. Clinical management of food protein-induced enterocolitis syndrome
- Author
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Miceli Sopo, Stefano, primary, Dello Iacono, Iride, additional, Greco, Monica, additional, and Monti, Giovanna, additional
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- 2014
- Full Text
- View/download PDF
14. Prevalence and Clinical Relevance of IgE Sensitization to Profilin in Childhood: A Multicenter Study.
- Author
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asero, Riccardo, Tripodi, Salvatore, Dondi, arianna, Di Rienzo Businco, andrea, Sfika, Ifigenia, Bianchi, annamaria, Candelotti, Paolo, Caffarelli, Carlo, Povesi Dascola, Carlotta, Ricci, Giampaolo, Calamelli, Elisabetta, Maiello, Nunzia, Miraglia del Giudice, Michele, Frediani, Tullio, Frediani, Simone, Macrì, Francesco, Moretti, Matteo, Dello Iacono, Iride, Patria, Maria Francesca, and Varin, Elena
- Subjects
HAY fever in children ,IMMUNOGLOBULIN E ,PROFILIN ,SENSITIZATION (Neuropsychology) ,POLLEN - Abstract
Background: Little is known about the prevalence and clinical relevance of hypersensitivity to the plant panallergen profilin in children. Objectives: The present study aimed to investigate prevalence, risk factors and clinical relevance of profilin sensitization in a large cohort of Italian children of different ages living in different geographic areas. Methods: Children with pollen allergy enrolled by 16 pediatric outpatient clinics sited in three main geographic areas of Italy were studied. SPT were carried out with commercial pollen extracts and a commercial purified date palm pollen profilin. IgE specific for allergenic pollen molecules, Phl p 12 (grass profilin) and Pru p 3 (peach lipid transfer protein) were tested by ImmunoCAP FEIA. Results: IgE to Phl p 12 (≥0.35 kU/l) was observed in 296 of the 1,271 participants (23%), including 17 of the 108 (16%) preschool children. Profilin SPT was positive (≥3 mm) in 320/1,271 (25%) participants. The two diagnostic methods were concordant in 1,151 (91%, p < 0.0001) cases. Phl p 12 IgE prevalence declined from northern to southern Italy and was directly associated with IgE to Phl p 1 and/or Phl p 5 and Ole e 1. Among children with IgE to Phl p 12, OAS was provoked by kiwi, melon, watermelon, banana, apricot and cucumber. Conclusions: Profilin sensitization is very frequent among pollen-allergic children, occurs at a very young age and contributes to the development of childhood OAS with a typical pattern of offending foods. Pediatricians should always consider IgE sensitization to profilin while examining pollen-allergic children, even if they are at preschool age. © 2015 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]
- Published
- 2015
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15. Specific oral tolerance induction with raw hen’s egg in children with very severe egg allergy: A randomized controlled trial
- Author
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Dello Iacono, Iride, primary, Tripodi, Salvatore, additional, Calvani, Mauro, additional, Panetta, Valentina, additional, Verga, Maria Carmela, additional, and Miceli Sopo, Stefano, additional
- Published
- 2012
- Full Text
- View/download PDF
16. Nutritional management and follow up of infants and children with food allergy: Italian Society of Pediatric Nutrition/Italian Society of Pediatric Allergy and Immunology Task Force Position Statement.
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Giovannini, Marcello, D'Auria, Enza, Caffarelli, Carlo, Verduci, Elvira, Barberi, Salvatore, Indinnimeo, Luciana, Dello Iacono, Iride, Martelli, Alberto, Riva, Enrica, and Bernardini, Roberto
- Subjects
DIET therapy for food allergies ,GROWTH disorders ,NUTRITION disorders in infants ,ANTHROPOMETRY ,CALCIUM ,DIET therapy ,CARBOHYDRATE content of food ,FOOD allergy ,INFANT nutrition ,INGESTION ,LIPIDS ,NUTRITIONAL assessment ,DIETARY proteins ,MICRONUTRIENTS ,VITAMIN D ,NUTRITIONAL status ,DISEASE complications ,CHILDREN ,PREVENTION ,DISEASE risk factors - Abstract
Although the guidelines on the diagnosis and treatment of food allergy recognize the role of nutrition, there is few literature on the practical issues concerning the nutritional management of children with food allergies. This Consensus Position Statement focuses on the nutritional management and follow-up of infants and children with food allergy. It provides practical advices for the management of children on exclusion diet and it represents an evidence-based consensus on nutritional intervention and follow-up of infants and children with food allergy. Children with food allergies have poor growth compared to non-affected subjects directly proportional to the quantity of foods excluded and the duration of the diet. Nutritional intervention, if properly planned and properly monitored, has proven to be an effective mean to substantiate a recovery in growth. Nutritional intervention depends on the subject's nutritional status at the time of the diagnosis. The assessment of the nutritional status of children with food allergies should follow a diagnostic pathway that involves a series of successive steps, beginning from the collection of a detailed diet-history. It is essential that children following an exclusion diet are followed up regularly. The periodic re-evaluation of the child is needed to assess the nutritional needs, changing with the age, and the compliance to the diet. The follow- up plan should be established on the basis of the age of the child and following the growth pattern. [ABSTRACT FROM AUTHOR]
- Published
- 2014
- Full Text
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17. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial.
- Author
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Dello Iacono, Iride, Tripodi, Salvatore, Calvani, Mauro, Panetta, Valentina, Verga, Maria Carmela, and Miceli Sopo, Stefano
- Subjects
- *
ALLERGY in children , *RANDOMIZED controlled trials , *SEVERITY of illness index , *DRUG tolerance , *CONTROL groups , *EMULSIONS , *ALLERGY treatment - Abstract
To cite this article: Dello Iacono I, Tripodi S, Calvani M, Panetta V, Verga MC, Miceli Sopo S. Specific oral tolerance induction with raw hen's egg in children with very severe egg allergy: A randomized controlled trial. Pediatr Allergy Immunol 2012: 00. Abstract Background: Treatment of severe egg allergy is avoidance of hen's egg (HE) and carrying self-injectable epinephrine. Specific oral tolerance induction (SOTI) seems a promising alternative treatment. However, some aspects of SOTI are still considered experimental. Methods: We evaluated the efficacy and safety of an original 6-month SOTI protocol in children with very severe HE allergy using raw HE emulsion. Twenty children (age range: 5-11 yr) were randomized equally into a SOTI treatment group and a control group. The treatment group started SOTI and underwent a second challenge 6 months later. Control children were kept on an egg-free diet for 6 months and then underwent a second challenge. Results: After 6 months, 9/10 children of the SOTI group (90%) achieved partial tolerance (at least 10 ml, but <40 ml of raw HE emulsion, in a single dose) and 1 (10%) was able to tolerate only 5 ml (no tolerance). After 6 months, nine control children tested positive to the second challenge at a dose ≤0.9 ml of raw HE emulsion, and one reacted to 1.8 ml (SOTI vs. control group p < 0.0001). All children in the SOTI group had side effects, but no child had a grade 5 reaction according to the Sampson grading. Conclusion: Six months of SOTI with raw HE emulsion resulted in partial tolerance, with regular intake, in a significant percentage of children with severe egg allergy. [ABSTRACT FROM AUTHOR]
- Published
- 2013
- Full Text
- View/download PDF
18. Case report: Goiter and overt hypothyroidism in an iodine-deficient toddler on soy milk and hypoallergenic diet
- Author
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Angela Maria Caprio, Giuseppina Rosaria Umano, Caterina Luongo, Francesca Aiello, Iride Dello Iacono, Stefania Palumbo, Emanuele Miraglia del Giudice, Anna Grandone, Caprio, Angela Maria, Umano, Giuseppina Rosaria, Luongo, Caterina, Aiello, Francesca, Dello Iacono, Iride, Palumbo, Stefania, Miraglia Del Giudice, Emanuele, and Grandone, Anna
- Subjects
goiter ,children ,Endocrinology, Diabetes and Metabolism ,cow’s milk allergy ,case report ,hypothyroidism ,soybean - Abstract
Soy-based infant formulas (SFs) are often consumed by cow’s milk allergic children. However, some concerns have risen since soy intake may adversely affect thyroid function in iodine-deficient or subclinical hypothyroid individuals. We report the first Italian case of SF induced goiter and hypothyroidism registered in our country since National Iodine program has been instituted. Finally, we review cases previously reported in literature. A 22-month-old toddler with a previous diagnosis of cow’s milk protein allergy came to clinical attention for important goiter and overt hypothyroidism. Detailed dietary anamnesis revealed that he was on a restrictive dietary regimen based on soymilk since 12 months of age. A temporary levothyroxine substitution was instituted to avoid hypothyroidism complications. Adequate iodine supplementation and diet diversification completely reversed SF-induced hypothyroidism and goiter, confirming the diagnostic suspicion of soymilk-induced thyroid dysfunction in a iodine-deficient toddler. This case report demonstrates the importance of careful dietary habits investigation and adequate micronutrients supplementation in children on a restrictive diet due to multiple food allergies in order to prevent nutritional deficits.
- Published
- 2022
19. Early molecular biomarkers predicting the evolution of allergic rhinitis and its comorbidities: A longitudinal multicenter study of a patient cohort
- Author
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Giovanna De Castro, Paolo Maria Matricardi, Ekaterina Potapova, Pasquale Comberiati, Ifigenia Sfika, Valentina Panetta, Giampaolo Ricci, Salvatore Tripodi, Anna Maria Zicari, Giulia Brindisi, Simone Pelosi, Viviana Moschese, Arianna Giannetti, Roberto Bernardini, Carla Mastrorilli, Francesca Cipriani, Carlo Caffarelli, Andrea Di Rienzo Businco, Michele Miraglia Del Giudice, Serena Perna, Iride Dello Iacono, Rosa Cervone, Marcella Gallucci, Valeria Villella, Antonella Casani, Elena Varin, Loredana Chini, Arianna Dondi, Cipriani, F., Tripodi, S., Panetta, V., Perna, S., Potapova, E., Dondi, A., Bernardini, R., Caffarelli, C., Casani, A., Cervone, R., Chini, L., Comberiati, P., De Castro, G., Miraglia Del Giudice, M., Dello Iacono, I., Di Rienzo Businco, A., Gallucci, M., Giannetti, A., Mastrorilli, C., Moschese, V., Pelosi, S., Sfika, I., Varin, E., Villella, V., Zicari, A. M., Brindisi, G., Ricci, G., Matricardi, P. M., Cipriani, Francesca, Tripodi, Salvatore, Panetta, Valentina, Perna, Serena, Potapova, Ekaterina, Dondi, Arianna, Bernardini, Roberto, Caffarelli, Carlo, Casani, Antonella, Cervone, Rosa, Chini, Loredana, Comberiati, Pasquale, De Castro, Giovanna, Miraglia Del Giudice, Michele, Dello Iacono, Iride, Di Rienzo Businco, Andrea, Gallucci, Marcella, Giannetti, Arianna, Mastrorilli, Carla, Moschese, Viviana, Pelosi, Simone, Sfika, Ifigenia, Varin, Elena, Villella, Valeria, Zicari, Anna Maria, Brindisi, Giulia, Ricci, Giampaolo, and Matricardi, Paolo Maria
- Subjects
Male ,Longitudinal study ,Pru p 3 ,Longitudinal Studie ,Immunoglobulin E ,medicine.disease_cause ,Atopy ,Allergen ,Risk Factors ,Surveys and Questionnaires ,Prevalence ,Immunology and Allergy ,Longitudinal Studies ,Prospective Studies ,skin and connective tissue diseases ,Child ,Sensitization ,Rhinitis ,biology ,Skin Test ,longitudinal study ,Bet v 1 ,IgE ,Phl p 1 ,Phl p 5 ,allergic rhinitis ,asthma ,biomarkers ,children ,comorbidities ,pollen ,prediction ,Adolescent ,Allergens ,Asthma ,Biomarkers ,Disease Progression ,Female ,Follow-Up Studies ,Humans ,Italy ,Rhinitis, Allergic ,Skin Tests ,medicine.anatomical_structure ,Cohort ,allergic rhiniti ,Human ,medicine.medical_specialty ,comorbiditie ,Immunology ,Follow-Up Studie ,Allergic ,Oral allergy syndrome ,Internal medicine ,medicine ,Settore MED/38 - Pediatria Generale e Specialistica ,business.industry ,Risk Factor ,fungi ,Biomarker ,medicine.disease ,body regions ,Prospective Studie ,Pediatrics, Perinatology and Child Health ,biology.protein ,business - Abstract
Background: Pollen-related seasonal allergic rhinoconjunctivitis (SAR) is a very frequent pediatric disease in Westernized countries. Risk factors and disease phenotypes have been thoroughly examined in several cross-sectional studies. By contrast, only a few studies have examined disease evolution in patient cohorts. We investigated predictive biomarkers of disease evolution in a large cohort of children with SAR. Methods: During 2015-2017 (follow-up), we re-examined 401 patients from those enrolled in 2009-2011 (baseline) by the “Panallergens in Pediatrics” study, a large multicenter survey of Italian children with SAR. Information on clinical history (standard questionnaire, AllergyCARD®; TPS, Italy) and skin prick tests for inhalant and foods extracts (ALK-Abelló, Hørsholm, Denmark) was acquired as at baseline visit. Evolution in clinical and sensitization data of patients was analyzed over time, as well as their association with the main baseline characteristics and atopy risk factors. Results: The average age of participants was 10.4±3.4years at baseline and 16.2±3.6years at follow-up. SAR persisted in 93.3% of patients at follow-up and became more frequently associated with asthma (from 36.7% at baseline to 48.6% at follow-up) and oral allergy syndrome (OAS, from 23.4% to 37.7%). Compared to baseline, the prevalence of skin sensitization to some pollens (Phleum pratense, Corylus avellana, Platanus acerifolia, Artemisia vulgaris) and vegetables (hazelnut, wheat, and apple) significantly decreased at follow-up. Earlier onset of SAR and polysensitization at baseline were associated with incident asthma at follow-up. The presence at baseline of serum IgE to the following allergen molecules was identified as biomarkers of clinical evolution: (a) Phl p 1, for persistence of SAR; (b) Phl p 5, for persistence of both rhinitis and asthma; (c) Pru p 3, for new onset of asthma; (d) Bet v 1, for persistence of OAS. Conclusions: Seasonal allergic rhinoconjunctivitis is clinically heterogeneous in its evolution from childhood to adolescence. The detection of serum IgE to specific molecules (Phl p 1, Phl p 5, Bet v 1, Pru p 3) may be useful as biomarkers to predict SAR persistence and future onset of comorbidities, such as asthma and/or OAS.
- Published
- 2018
20. Oral immunotherapy for egg allergy in children.
- Author
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Dello Iacono I, Verga MC, Tripodi S, Dello Iacono, Iride, Verga, Maria C, and Tripodi, Salvatore
- Published
- 2012
- Full Text
- View/download PDF
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