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The emergence of SARS-CoV-2 variants has significantly impacted the global response to the COVID-19 pandemic. This review examines the genetic diversity of SARS-CoV-2 variants, their roles in epidemiological tracking, and their influence on viral fitness. Variants of concern (VOCs) such as Alpha, Beta, Gamma, Delta, and Omicron have demonstrated increased transmissibility, altered pathogenicity, and potential resistance to neutralizing antibodies. Epidemiological tracking of these variants is crucial for understanding their spread, informing public health interventions, and guiding vaccine development. The review also explores how specific mutations in the spike protein and other genomic regions contribute to viral fitness, affecting replication efficiency, immune escape, and transmission dynamics. By integrating genomic surveillance data with epidemiological and clinical findings, this review provides a comprehensive overview of the ongoing evolution of SARS-CoV-2 and its implications for public health strategies and new vaccine development. [ABSTRACT FROM AUTHOR]

AbstractAlthough tension reduction is a key principle in drive theory, there are clear dynamic aspects of libido expression aimed at increased tension levels. In a paradigmatic shift from the Freudian conflict model, tension reduction and tension enhancement dynamics are re-conceptualized as valences toward the processes of tension reduction and tension enhancement, rather than toward the respective states of reduced tension or enhanced tension. We posit a unitary direction-independent foundational id drive toward tension level change which incorporates tension reduction and enhancement. As the primary drive circumscribed to manipulations of id tension level, the dynamics of Delta are distinguished from those of Eros and Thanatos whose purviews are in the domain of drive purpose/function (or evolutionary design) and also differentiated from the subjective phenomenological experience of drive expression which varies among people. Theoretical and clinical issues in sexuality and aggression are critically analyzed as entailing libidinal elements of tension enhancement and reduction. Key points are annotated with illustrative clinical vignettes. The intersections between Delta dynamics, ego psychology, and object relations are explored. Possible elaborations of sub-drive development entailing functional autonomy are outlined. [ABSTRACT FROM AUTHOR]

Throughout the COVID-19 pandemic, the emergence of new viral variants has challenged public health efforts, often evading antibody responses generated by infections and vaccinations. This immune escape has led to waves of breakthrough infections, raising questions about the efficacy and durability of immune protection. Here we focus on the impact of SARS-CoV-2 Delta and Omicron spike mutations on ACE-2 receptor binding, protein stability, and immune response evasion. Delta and Omicron variants had 3–5 times higher binding affinities to ACE-2 than the ancestral strain (KDwt = 23.4 nM, KDDelta = 8.08 nM, KDBA.1 = 4.77 nM, KDBA.2 = 4.47 nM). The pattern recognition molecule mannose-binding lectin (MBL) has been shown to recognize the spike protein. Here we found that MBL binding remained largely unchanged across the variants, even after introducing mutations at single glycan sites. Although MBL binding decreased post-vaccination, it increased by 2.6-fold upon IgG depletion, suggesting a compensatory or redundant role in immune recognition. Notably, we identified two glycan sites (N717 and N801) as potentially essential for the structural integrity of the spike protein. We also evaluated the antibody and T cell responses. Neutralization by serum immunoglobulins was predominantly mediated by IgG rather than IgA and was markedly impaired against the Delta (5.8-fold decrease) and Omicron variants BA.1 (17.4-fold) and BA.2 (14.2-fold). T cell responses, initially conserved, waned rapidly within 3 months post-Omicron infection. Our data suggests that immune imprinting may have hindered antibody and T cell responses toward the variants. Overall, despite decreased antibody neutralization, MBL recognition and T cell responses were generally unaffected by the variants. These findings extend our understanding of the complex interplay between viral adaptation and immune response, underscoring the importance of considering MBL interactions, immune imprinting, and viral evolution dynamics in developing new vaccine and treatment strategies. [ABSTRACT FROM AUTHOR]

Background: F-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex following prolonged TMS interventions, as assessed by quantitative electroencephalography (qEEG), remains insufficiently explored. This study aims to demonstrate the qEEG-based distinctions between rTMS and dTMS in the management of depression and to evaluate the potential correlation between the electrophysiological changes induced by these two distinct TMS interventions and the clinical improvement in depressive and anxiety symptoms. Methods: A total of 60 patients diagnosed with treatment resistant depression received rTMS (n = 30) or dTMS (n = 30) along with their usual treatments in Kemal Arıkan Psychiatry Clinic. All the participants underwent resting-state qEEG recording before and at the end of 30 sessions of TMS treatment. The significant qEEG changes were then tested for their correlation with the improvement in depression and anxiety. Results: After the course of rTMS and dTMS a considerable reduction is seen in the severity of depression and anxiety. Although improvements in depression and anxiety were observed in both TMS groups, specific neural activity patterns were associated with better outcomes in depression. Patients who exhibited lower alpha activity in the left fronto-central region and higher gamma activity in the right prefrontal region following rTMS showed more significant improvements in depression symptoms. Similarly, those whose beta activity increased in the left prefrontal region but decreased in the right prefrontal region after rTMS tended to have greater reductions in depression and anxiety severity. For patients in the dTMS group, those who demonstrated a decrease in left temporal theta activity after treatment were more likely to experience a substantial improvement in depression severity. Conclusion: Following 30 sessions of rTMS with a F8 coil and dTMS with an H1 coil, notable alterations in qEEG activity with clinical significance were discerned. The persistence of these changes should be investigated in the subsequent follow-up period. [ABSTRACT FROM AUTHOR]

Background: An estimated 1.1–1.4 million children die from pneumonia each year, making up 17–19% of all paediatric mortality; the majority of these deaths occur in underdeveloped nations. In Egypt, during the first 2 years of life, about 6% of children have at least one pneumonic episode. Aims: (a) Determination of the prevalence of community-acquired pneumonia (CAP) among children in Egypt's Delta region, both generally and specifically in rural regions, and (b) evaluation of each case's clinical and epidemiological phenotypes. Subjects and methods: A cross-sectional study was carried out on 174 rural children who were admitted to Mansoura University Children Hospital (MUCH) between 2016 and 2022 and had a confirmed diagnosis of CAP. Two categories were created for the cases: both typical and atypical CAP. Results: Out of 39,130 admitted cases, a total of 768 children from Delta region fitted the diagnosis of CAP with an overall prevalence of 1.96% (45.6% from rural areas). Data of 174 cases with CAP were evaluated, and 125 (71.8%) were diagnosed with typical CAP and 49 (28.2%) with atypical CAP. There was a statistically significant difference between typical and atypical CAP groups regarding age and sex. Recurrent pneumonia was significantly more prevalent among children with typical CAP. The prevalence of complications was significantly higher among typical CAP cases compared to atypical CAP cases (P < 0.001). Bronchopneumonia was the most frequent radiologic findings among typical CAP cases (28.0%), while interstitial pneumonia was the most among atypical CAP cases (46.9%). Children with typical CAP had a significantly higher percentage of positive CRP (68.8%) compared to those with atypical CAP (32.7%). Staph coagulase negative was the most identified pathogen among all cases (12.78%). Children with typical CAP had a significantly lower frequency of macrolides use compared to those with atypical CAP (8.8%) vs. (98.0%). Conclusion: Among the Delta region, the prevalence of CAP among children is 1.96% (45.6% in rural regions). Compared to atypical CAP, typical CAP affects children more frequently (71.8%) and results in a more severe form of the disease in terms of clinical symptoms, sequelae, and radiological abnormalities. [ABSTRACT FROM AUTHOR]

Throughout the COVID-19 pandemic, the emergence of new viral variants has challenged public health efforts, often evading antibody responses generated by infections and vaccinations. This immune escape has led to waves of breakthrough infections, raising questions about the efficacy and durability of immune protection. Here we focus on the impact of SARS-CoV-2 Delta and Omicron spike mutations on ACE-2 receptor binding, protein stability, and immune response evasion. Delta and Omicron variants had 3–5 times higher binding affinities to ACE-2 than the ancestral strain (KDwt = 23.4 nM, KDDelta = 8.08 nM, KDBA.1 = 4.77 nM, KDBA.2 = 4.47 nM). The pattern recognition molecule mannose-binding lectin (MBL) has been shown to recognize the spike protein. Here we found that MBL binding remained largely unchanged across the variants, even after introducing mutations at single glycan sites. Although MBL binding decreased post-vaccination, it increased by 2.6-fold upon IgG depletion, suggesting a compensatory or redundant role in immune recognition. Notably, we identified two glycan sites (N717 and N801) as potentially essential for the structural integrity of the spike protein. We also evaluated the antibody and T cell responses. Neutralization by serum immunoglobulins was predominantly mediated by IgG rather than IgA and was markedly impaired against the Delta (5.8-fold decrease) and Omicron variants BA.1 (17.4-fold) and BA.2 (14.2-fold). T cell responses, initially conserved, waned rapidly within 3 months post-Omicron infection. Our data suggests that immune imprinting may have hindered antibody and T cell responses toward the variants. Overall, despite decreased antibody neutralization, MBL recognition and T cell responses were generally unaffected by the variants. These findings extend our understanding of the complex interplay between viral adaptation and immune response, underscoring the importance of considering MBL interactions, immune imprinting, and viral evolution dynamics in developing new vaccine and treatment strategies. [ABSTRACT FROM AUTHOR]

Objective: To establish lactate and glucose differences between affected and non-affected limbs in cats with feline arterial thromboembolism (FATE). To evaluate the correlation between these values and survival to discharge as well as congestive heart failure (CHF). Methods: Blood glucose and lactate concentrations were prospectively obtained on admission from client-owned FATE cats and client-owned cats presented for other conditions. The glucose and lactate concentrations of the front limbs (or non-affected) and the hind limbs (or affected) were measured. Lactate (Δlactate) and glucose (Δglucose) differences between the two limbs were calculated. Results: The FATE group and control groups included 18 and 41 cats, respectively. The median age of the cats within the FATE group and control groups was 9.5 years and 5 years, respectively. The median Δlactate was significantly higher in the FATE group than in the control group (7.2 mmol/L versus 0.1 mmol/L, respectively; p ≤ 0.01). The median Δglucose was significantly higher in the FATE group than in the control group (155 mg/dL versus 3 mg/dL, respectively; p ≤ 0.01). A diagnosis of FATE was made using a ∆lactate cutoff of 2.2 mmol/L (100% sensitivity and 95% specificity) or a ∆glucose cutoff of 41 mg/dL (100% sensitivity and specificity). There was no correlation between Δlactate and Δglucose and survival to discharge. A higher ∆glucose was significantly associated with concurrent CHF (p = 0.01). Conclusion: Both Δlactate and Δglucose were accurate diagnostic tools for cats with FATE. Neither were correlated with survival to discharge. Higher Δglucose values were significantly associated with the presence of CHF. [ABSTRACT FROM AUTHOR]

Basidiomata belonging to the genus Candolleomyces were collected from plains of Punjab, Pakistan, and characterized based on morpho-anatomical and phylogenetic analyses. In phylograms nrITS & nrLSU regions were used to ascertain exact positions of our new taxa in this genus. Three novel taxa, Candolleomyces granulosis, C. pabbiensis and C. umbonatus formed independent phylogenetic relationships within the genus Candolleomyces. With this addition, the taxa of Candolleomyces has become to 46. A key to the Asian Candolleomyces species is also given. [ABSTRACT FROM AUTHOR]

In the region of In Amenas (south-eastern Algeria) Triassic deposits crop out, on top of Palaeozoic rocks under an angular unconformity. Astudy of their sedimentological and palaeoenvironmental characteristics has revealed asandy-clay unit with vertebrate remains, tree trunks and ichnofossils of Middle-Late Triassic age. This so-called Zarzaitine Formation, which reflects deposition in adeltaic environment, shows three facies associations. The first defines an upper and shallow intertidal mixed flat zone with in-situ temnospondyl capitosauroid remains, associated with Skolithos ichnofacies, while the second one defines alower intertidal delta plain zone, composed of sandstone, distributary channels and muddy interdistributary areas,which record daily tidal rhythmites and monthly tidal bundles. The third, and last, facies association represents an upper delta plain of the supratidal zone, characterised by coarse sandstone deposits of braided rivers and aCycadophyta palaeosol. Previous work, which led to considering these Triassic deposits as aseries composed of four formations, deposited in abraided rivers environment, whose lower floodplains constituted ecological niche for atemnospondyl fauna, under hot and dry climatic conditions and plants belonging to this same formation, for mushrooms and algae, will also be considered. [ABSTRACT FROM AUTHOR]

During January and February 2022, a huge spike in the cases of COVID-19 was recorded in the Khyber Pakhtunkhwa (KP) province of Pakistan prompting the civil administration to institute new restrictions. To investigate the underlying causes of this surge, the regional Public Health Reference Lab (PHRL) launched a screening effort throughout the Province's remote and urban areas. Herein, we present our survey results during the peak months of the pandemic. The data indicated the prevalence of highly transmissible delta- and Omicron-like virus variants, which may explain the rise in positive cases. Phylogenetic analysis revealed the genetic association between the sequences from this study and those found in Pakistan as well as from geographically distant countries, suggesting a complex evolutionary history. For screening, we deployed an easy-to-use single primer-based polymerase chain reaction (PCR) assay to identify the circulation of SARS-CoV-2. The assay was validated using clinical swabs of COVID-19 patients and obtained consistent results with Sanger sequencing. Our survey identified a patient simultaneously infected with two variants of concern, indicating the presence of the Deltacron variant, although we cannot discount the possibility of sequencing errors. We recommend that SARS-CoV-2 be continuously monitored to detect single nucleotide polymorphisms (SNPs) that are causally linked to the emergence of new lineages. Our method provides a rapid and cost-effective detection assay for SARS-CoV-2 in a resource-constrained setting. [ABSTRACT FROM AUTHOR]

Rabbit viral haemorrhagic disease (RVHD) is a fatal threat to rabbits causing long-term problems and significant economic losses. In the current study, RVHD was identified and characterised in naturally infected rabbits in order to assess the genetic diversity of RHDV circulating in different Egyptian provinces from January 2019 to January 2022. Nineteen suspected samples were collected from outbreaks that occurred in nine provinces during 2019-2022. Ten liver samples out of nineteen were positive in the slide and plate haemagglutination (HA) test. HA titres ranged from 5 log2 to 12 log2. RHDV-positive liver homogenates were confirmed with RT-PCR and histopathology. Further characterisation of the selected four viral strains was performed by nucleotide sequencing of VP60 gene. Based on nucleotide sequence analysis, three isolates were identified as RHDV2 strains, while one isolate was assigned as RHDV1 strain. [ABSTRACT FROM AUTHOR]

Pluripotent somatic stem cells are the drivers of unlimited growth of Echinococcus multilocularis metacestode tissue within the organs of the intermediate host. To understand the dynamics of parasite proliferation within the host, it is therefore important to delineate basic mechanisms of Echinococcus stem cell maintenance and differentiation. We herein undertake the first step towards characterizing the role of an evolutionarily old metazoan cell–cell communication system, delta/notch signalling, in Echinococcus cell fate decisions. Bioinformatic analyses revealed that all central components of this pathway are encoded by the Echinococcus genome and are expressed in parasite larval stages. By in situ hybridisation, we analyzed the expression patterns of clearly identified delta-like ligands, delta1 and delta2, as well as two notch receptors, notch1 and notch2, in metacestode tissue. Except for delta1, which is not expressed in the metacestode, all other components are expressed in distinct cells throughout the parasite’s germinal layer. Combined in situ hybridisation and EdU incorporation experiments together with pulse-chase assays further indicate that delta2, notch1, and notch2 are exclusively expressed in post-mitotic cells. Echinococcus asymmetric stem cell division, leading to the progeny of different fates, therefore most probably not involves delta/notch signalling components. Our analyses are relevant for understanding the interplay of fate-determining signalling pathways in Echinococcus cell differentiation and form a basis for further experiments into the role of delta/notch signalling in parasite development. [ABSTRACT FROM AUTHOR]

The objective of this work is to update and improve the existing cartography on the spatial distribution of native forests in the Buenos Aires province, Argentina. It was developed within the framework of a project executed by researchers of the national scientific and technological system for the Dirección de Bosques of the Ministerio de Ambiente de la Provincia de Buenos Aires, focusing on the design and execution of a uniform methodology for the identification and delineation of native forest covers for the entire province. The cartographic update used a combination of field-collected information, complemented with visual interpretation of multitemporal series of high-resolution optical images, generalized using machine learning algorithms fed with information derived from Sentinel-2 multispectral satellite image series. The products obtained were evaluated using metrics derived from the contingency matrix, calculated from field-labeled data. The methodology used for automatic classification is detailed, including the methodology for labeling training points, the spectral information used to feed the classifiers, the selection of the classification methodology itself, as well as the details of the post-processing procedure applied to each specific forest formation and the evaluation of the final products obtained. The delineation obtained excludes 235182 ha from the 968397 ha of the current map, which we consider to not correspond to native forests, and incorporates 187512 ha of native forests that had not been previously mapped, reducing the total mapped area of native forests in the province by 4.9%. The evaluation, carried out with 719 field-labeled points, assigns an overall accuracy of 0.89 and a kappa index of 0.85 to the classification obtained, indicating that the proposed methodology is suitable for the delineation of native forests in the province. [ABSTRACT FROM AUTHOR]

River fluxes to the Arctic Ocean impact sea ice extent, nutrient availability, and coastal ecosystems. Arctic river deltas modulate fluxes of water, sediment, and nutrients reaching the Arctic Ocean. Many large rivers have estimates or measurements of discharge and sediment concentration upstream of the delta apex, but the magnitude, timing, and spatial distribution of sediment fluxes to the Arctic coast are unknown. We developed a novel reduced‐complexity model of suspended sediment transport in Arctic deltas to address this knowledge gap. The model estimates suspended sediment delivery to the coast based on a computed channel network and sediment transport rules. We applied this model to six high‐latitude deltas during their open water seasons with different boundary conditions to account for their differences in morphology, seasonality, and hydrology. Flux distributions at the coast are found to be more uneven in larger deltas due to uneven channel spacing and larger variability in channel widths compared with smaller deltas. Given typical active season conditions, the deltas exhibit periods of deposition and erosion but are net depositional overall. Net sediment trapping during the active season ranges from 10% to 70%. Our results suggest that larger, more complex deltas with higher sediment supply and less flashy hydrographs store the most sediment and may therefore be more resilient to land loss. The sediment flux distribution can be used in future studies of coastal biogeochemistry and geomorphology and in regional models to capture the impacts of fluxes on turbidity, marine primary productivity, and Arctic warming. Plain Language Summary: Deltas affect river fluxes of water and sediments to the ocean, which are important for coastal processes. Fluxes to the Arctic Ocean are unknown because of the deltas, so we developed a model to estimate sediment and water fluxes in deltas at the end of several large Arctic rivers. We found that the river inputs and delta size are important factors in flux delivery to the coast, which has implications for nutrient cycling and delta growth in these coastal regions. Key Points: We developed a novel reduced‐complexity model of suspended sediment transport in Arctic deltasArctic deltas store a significant portion of the upstream suspended sediment flux from riversLarge deltas with high sediment supply and longer periods of moderate discharge store the most sediment [ABSTRACT FROM AUTHOR]

Background: Dynamics, severity, and immune response of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection vary between children and adults. There are only a few reports on the differential impact of variants in children, and none reported from low-and-middle-income countries. Materials and Methods: Between November 2020 and August 2021, we enrolled children under 16 years testing positive for SARS-CoV-2 by polymerase chain reaction (PCR). We compared virus characteristics (viral load, virus variant - Wild-type or Delta), disease severity (asymptomatic, mild-to-moderate, and severe), and immunity levels to the virus (anti-N and anti-S) after 4–6 weeks. Results: Of 79 children recruited, 29%, 59%, and 11% had asymptomatic, mild-to moderate, or severe presentations, respectively. Wild-type and delta variants presented with similar disease severity. For both variants, anti-S antibody levels were higher than anti-N antibody levels (P < 0.0001). Anti-S was also higher than anti-N among asymptomatic (P = 0.02) and mild-to-moderate disease (P < 0.0001). Children with higher virus loads had higher levels of both anti-S and anti-N antibodies (quartile [QS]1 versus QS3, P < 0.05). Among low (QS3) virus loads, wild-type anti-S levels were higher than delta infected (P = 0.003). In mild-to-moderate disease, the mean Ct value of wild type (32.5) was higher than that of delta infection (25.0) (P = 0.0083). Conclusions: In children, the antibody response is driven by viral load. In mild-to-moderate disease, higher loads of Delta variant of concern resulted in robust antibody response that was absent in severe disease. These results could inform potential responses to future SARS-CoV-2 variants and may guide decisions on targeted vaccination in children.

The Delta Smelt is a largely zooplank­tivorous, endangered fish endemic to the San Francisco Estuary (the estuary). High flows increase the availability of fresh and brackish water habitat for Delta Smelt, but also may mobilize contaminants, potentially increasing toxicological stress. Here, we examine the association between contaminants and Delta Smelt health across contrasting water year types and flow-related management actions. Our study spanned the fall season of three years: 1 dry year (2018) bracketed by 2 wet years (2017 and 2019) and coincided with several management actions meant to benefit Delta Smelt. We collected field water from six sites in the estuary that encompass the freshwater and low-salinity habitat of Delta Smelt and analyzed the water for contaminant concentrations. After a 96-hour exposure to the field water, we assessed cultured Delta Smelt survival and the histopathological condition of the gill and liver. Insecticides, particularly fipronil metabolites, were the most prevalent contaminants detected in 2017 and 2018, and a variety of contaminants associated with the rice harvest were detected in 2019. No acute toxicity was observed during any exposure, but we observed negative effects in the livers of Delta Smelt exposed to agricultural water from the Toe Drain and Cache Slough during a 2019 pulse flow action, which coincided with elevated detections and concentrations of organic pesticides. Other noteworthy sub-lethal effects, likely occurring in response to contaminant mixtures, included severe gill lesions in Delta Smelt exposed to Decker Island water in 2019. In the drier year of 2018, lesions were generally mild or absent. Thus, the trade-offs between increased habitat availability and contaminant loading may provide one explanation for why Delta Smelt abundance does not consistently respond positively to outflow.

Abstract Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), led to a global pandemic from 2020. In Thailand, five waves of outbreaks were recorded, with the fourth and fifth waves driven by the Delta and Omicron variants, resulting in over 20,000 new confirmed cases daily at their peaks. Methods This cross-sectional study investigated the associations between clinical symptoms, vaccination status, antibody responses, and post-COVID-19 sequelae in COVID-19 patients. Plasma samples and clinical data were collected from participants admitted to hospitals in Thailand between July 2021 and August 2022, with follow-ups conducted for one year. The study included 110 participants infected with either the Delta (n = 46) or Omicron (n = 64) variants. Virus genotypes were confirmed by RT-PCR of nasal swab RNA and partial nucleotide sequencing of the S gene. IgG and IgA antibody levels against the receptor-binding domain (RBD) of SARS-CoV-2 Delta and Omicron variants were measured in plasma samples using ELISA. Results Pneumonia was found to be associated with Delta variant infections, while sore throat, congestion or runny nose, and headache were linked to Omicron infections. Vaccination with fewer than two doses and diabetes mellitus were significantly associated with higher disease severity. Specific IgG and IgA antibodies against the RBD of the Delta variant generally rose by day 14 and were maintained for up to two months, whereas the pattern of antibody response to the Omicron variant was less clear. Antibody risings were found to be positively associated with pneumonia, certain underlying conditions (obesity, hypertension, dyslipidemia, and diabetes mellitus), and age ≥ 60 years. Delta variant infections were associated with forgetfulness, hair loss, and headache during the 1-year post-infection period. Females were more likely to experience hair loss, forgetfulness, and joint pain, while older age was associated with joint pain. Conclusions This study enhances our understanding of SARS-CoV-2 infections in Thais, particularly concerning the Delta and Omicron variants. The findings can inform public health planning and response strategies for future outbreaks of SARS-CoV-2 or other emerging viral diseases.

Abstract Background Determination of SARS-CoV-2 variant is significant to prevent the spreads of COVID-19 disease. Methods We aimed to evaluate the variants of SARS-CoV-2 rate in positive patients in Kanuni Sultan Suleyman Training and Research Hospital (KSS-TRH), Istanbul, Türkiye between 1st January and 30th November 2021 by using RT-PCR method. Results Herein, 825,169 patients were evaluated (male:58.53% and female:41.47%) whether COVID-19 positive or not [( +):21.3% and (−):78.7%] and 175,367 patient was described as positive (53.2%-female and 46.8%-male) by RT-PCR. COVID-19 positive rate is observed highest in the 6–15- and 66–75-year age range. The frequencies were obtained as SARS-CoV-2 positive (without mutation of B.1.1.7 [B.1.1.7 (U.K), E484K, L452R, B.1.351 (S. Africa/Brazil) spike mutations] as 66.1% (n: 115,899), B.1.1.7 Variant as 23.2% (n:40,686), Delta mutation (L452R) variant as 9.8% (n:17,182), B.1.351 variant as 0.8% (n:1370) and E484K as 0.1% (n: 230). In April 2021, general SARS-CoV-2 and B.1.1.7 variant were dominantly observed. Up to July 2021, B.1.617.2 (Delta variant/ Indian variant) and E484K has been not observed. B.1.351 variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. African/Brazil variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. When the gender type is compared within the variants, women were found to be more prevalent in all varieties. Conclusions The meaning of these mutations is very important to understand the transmission capacity of the COVID-19 disease, pandemic episode, and diagnosis of the virus with mutation types. Understanding the variant type is important for monitoring herd immunity and the spread of the disease.

Abstract The emergence of the SARS-CoV-2 virus led to a global pandemic, prompting extensive research efforts to understand its molecular biology, transmission dynamics, and pathogenesis. Recombination events have been increasingly recognized as significant contributor to the virus’s diversity and evolution, potentially leading to the emergence of novel strains with altered biological properties. Indeed, recombinant lineages such as the XBB variant and its descendants have subsequently dominated globally. Therefore, continued surveillance and monitoring of viral genome diversity are crucial to identify and understand the emergence and spread of novel strains. Through routine genomic surveillance of SARS-CoV-2 cases in Norway, we discovered a SARS-CoV-2 recombination event in a long-term infected immunocompromised COVID-19 (coronavirus disease) patient. A deeper investigation showed several recombination events between two distinct lineages of the virus, namely AY.98.1 and BA.5, that resulted in a single novel recombinant viral strain with a unique genetic signature. Our data is consistent with the presence of several concomitant recombinants in the patient, suggesting that these events occur frequently in vivo. This study underscores the importance of continued tracking of viral diversity and the potential impact of recombination events on the evolution of the SARS-CoV-2 virus.

Abstract Naumure Multipurpose Project (NMP) featuring a 169 m high Concrete Face Rock Filled Dam (CFRD) is the proposed reservoir project in the West Rapti River with an installed capacity of 218.34 MW. Most of the rivers in Nepal carry significant sediment loads that will consequently catalyze reservoir sedimentation. This phenomenon prevails as the primary factor in reducing reservoirs useful life, making ineffective for both flood control and hydroelectricity generation. Ultimately, such process of sedimentation has adverse impacts on projects economic feasibility and long-term sustainability. Therefore, the objective of this research was to examine the expected sediment deposition pattern in the NMP reservoir throughout its operational period by employing 1D HEC-RAS model to simulate the sedimentation process. The model was simulated for 10, 20, 30, 40 and 50 years. Yang’s equation as a sediment transport function, Active layer as a bed sorting method and Toffaleti as a fall velocity method were best suited for the river reach. The delta deposition was formed between 11 km and 22 km upstream of the dam region in the Jhimruk river, with the sediment deposition depth reaching peaks of about 23 m, 38 m, 39 m, 41 m and 49 m in 10, 20, 30, 40 and 50 years, respectively. Similarly, the delta deposition was formed between 13 km and 33 km upstream of dam region in the Madi river, with the sediment deposition depth reaching peaks of about 47 m, 62 m, 60 m, 68 m and 75 m in 10, 20, 30, 40 and 50 years respectively. Headcutting of delta deposition occurred between 20 and 30 year due to high flood during low stage of reservoir. Furthermore, the study revealed that about 6.22%, 11.61%, 15.94%, 22.96% and 25.65% of the storage capacity of NMP reservoir will be depleted in 10, 20, 30, 40 and 50 years respectively.

Aim: To study the manifestations of the COVID-19 epidemic and the clinical and epidemiological characteristics of adult patients with a new coronavirus infection during the dominance of the Delta SARS-COV-2 in the Russian Federation.Materials and Methods: Study included patients aged ≥18 years with a laboratory-confirmed diagnosis of COVID-19, detected in the period from 09/01/2021 to 11/30/2021 (n= 2 619 298) in 85 Russian regions.Results: There were 2 periods of rise and decline in the COVID-19 incidence and mortality during the spread of the Delta SARS-CoV-2 in Russia: June-September and OctoberDecember 2021 (Wald – Wolfowitz criterion, p

Mangrove forests are critical coastal ecosystems that provide great socio‐ecological services, which are also highly vulnerable to climate change, particularly to sea level rise (SLR). Here we assess changes in mangrove forests in four distinct river/tide/wave‐dominant large deltas along the Indo‐Pacific coast based on 1,336 remote sensing images by machine learning techniques. We find that mangroves are migrating seaward at a rate of 18% ± 12% m/yr, which can offset landward mangroves loss, 67% of which caused by land use conversion. The fact that mangroves are expanding seaward with accretion rates exceeding SLR suggests that climate change has not yet triggered substantial loss in deltaic mangrove forests. Assuming that present environmental conditions do not change and that sediment and organic deposition in the deltaic topsets match SLR rates, we project that 90% of deltaic mangrove forests may start to retreat after 132–194 years. Early inundation of mangroves will occur in wave‐dominated delta. Plain Language Summary: Mangrove forests provide significant ecological and societal services, and mitigation global warming. However, large‐scale loss in mangroves could be induced by anthropogenic drivers and sea level rise (SLR). Our study based on deltas along the Indo‐Pacific coast, highlight that mangroves are expanding seaward at a rate of 18% ± 12% m/yr, indicating that there is little impacts from SLR and has not been substantial loss in mangrove forests in these deltas so far. Mangrove expansion here can efficiently offset 67% landward mangrove losses indicates that our new model project that 90% of mangrove shorelines will may start retreating within 132–194 years. We conclude that favoring mangroves expansion seaward would enhance coastal protection and reduce the need of landward mangrove restoration. Key Points: Mangroves along typical deltas are expanding seaward of about 18% ± 12% m/yr, indicating that there is little impacts from sea level riseMangrove expansion here can efficiently offset 67% landward mangrove lossesNew model project that 90% of mangrove fringes may start retreating within 132–194 years, and wave‐dominated delta present early inundation [ABSTRACT FROM AUTHOR]

River sediment supply (Qs) and longshore sediment transport (LST) are recognized as two paramount controls on river delta morphodynamics and stratigraphy. We employed the Delft3D model to simulate the evolution of deltas from fluvial to wave‐dominated conditions, revealing the interplay between river‐ and wave‐driven sediment quantities. Wave‐influenced deltas may show alternating accumulation and retreat patterns driven by avulsions and wave‐induced sediment diffusion, posing coastal management challenges. Deltas with higher wave energy evolve under a fine balance between river supply and intense wave‐mediated sediment redistribution and are highly vulnerable under conditions of sediment reduction. Reducing Qs by ∼40%–70%, common in modern dammed rivers, can rapidly shift bypass from ∼0 to 1 (no bypass to complete bypass). This leads to accelerated diffusion and potential sediment loss in modern deltas. The study highlights the importance of accurately computing sediment quantities in real‐world deltas for improved management, especially under increasing anthropogenic and climatic pressures. Plain Language Summary: Ocean waves, like proficient sculptors, shape the meeting points of rivers and seas—where deltas are created. Under the power of ocean waves, the sediments transported by rivers are organized into distinct patterns. Using an advanced computer model, our research unveils how this interplay affects the physical form of these deltas and their functioning. In certain conditions, the sediment carried by waves can jump over the river mouth and move further along the coastline, contributing to stretching the delta and inducing erosion. Currently, river sediments are getting blocked behind river dams, depriving deltas of their sediment nourishment. As sediment supply decreases, powerful waves at the sea erode deltas more easily, endangering ecosystems, human communities and infrastructure. Because deltas are facing challenges from climate change and increased human activities, informed and innovative management strategies based on better knowledge of natural processes are needed to preserve these valuable coastal regions. Key Points: Deltas transition from avulsion‐dominated with localized depocenters to more diffuse and alongshore‐deflected wave‐dominated depocentersBypass increases and trapping decreases abruptly when longshore transport (LST) at the river mouth equals river sediment transport (Qs)LST under large‐scale blocking due to mouth bar and shoreface adjustment feeds wave‐dominated updrift beach ridge plains (strandplains) [ABSTRACT FROM AUTHOR]

Background: Determination of SARS-CoV-2 variant is significant to prevent the spreads of COVID-19 disease. Methods: We aimed to evaluate the variants of SARS-CoV-2 rate in positive patients in Kanuni Sultan Suleyman Training and Research Hospital (KSS-TRH), Istanbul, Türkiye between 1st January and 30th November 2021 by using RT-PCR method. Results: Herein, 825,169 patients were evaluated (male:58.53% and female:41.47%) whether COVID-19 positive or not [(+):21.3% and (−):78.7%] and 175,367 patient was described as positive (53.2%-female and 46.8%-male) by RT-PCR. COVID-19 positive rate is observed highest in the 6–15- and 66–75-year age range. The frequencies were obtained as SARS-CoV-2 positive (without mutation of B.1.1.7 [B.1.1.7 (U.K), E484K, L452R, B.1.351 (S. Africa/Brazil) spike mutations] as 66.1% (n: 115,899), B.1.1.7 Variant as 23.2% (n:40,686), Delta mutation (L452R) variant as 9.8% (n:17,182), B.1.351 variant as 0.8% (n:1370) and E484K as 0.1% (n: 230). In April 2021, general SARS-CoV-2 and B.1.1.7 variant were dominantly observed. Up to July 2021, B.1.617.2 (Delta variant/ Indian variant) and E484K has been not observed. B.1.351 variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. African/Brazil variant of SARS-CoV-2 has been started in February 2021 at the rarest ratio and March 2021 is the top point. September 2021 is the pick point of E484K. When the gender type is compared within the variants, women were found to be more prevalent in all varieties. Conclusions: The meaning of these mutations is very important to understand the transmission capacity of the COVID-19 disease, pandemic episode, and diagnosis of the virus with mutation types. Understanding the variant type is important for monitoring herd immunity and the spread of the disease. [ABSTRACT FROM AUTHOR]

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), led to a global pandemic from 2020. In Thailand, five waves of outbreaks were recorded, with the fourth and fifth waves driven by the Delta and Omicron variants, resulting in over 20,000 new confirmed cases daily at their peaks. Methods: This cross-sectional study investigated the associations between clinical symptoms, vaccination status, antibody responses, and post-COVID-19 sequelae in COVID-19 patients. Plasma samples and clinical data were collected from participants admitted to hospitals in Thailand between July 2021 and August 2022, with follow-ups conducted for one year. The study included 110 participants infected with either the Delta (n = 46) or Omicron (n = 64) variants. Virus genotypes were confirmed by RT-PCR of nasal swab RNA and partial nucleotide sequencing of the S gene. IgG and IgA antibody levels against the receptor-binding domain (RBD) of SARS-CoV-2 Delta and Omicron variants were measured in plasma samples using ELISA. Results: Pneumonia was found to be associated with Delta variant infections, while sore throat, congestion or runny nose, and headache were linked to Omicron infections. Vaccination with fewer than two doses and diabetes mellitus were significantly associated with higher disease severity. Specific IgG and IgA antibodies against the RBD of the Delta variant generally rose by day 14 and were maintained for up to two months, whereas the pattern of antibody response to the Omicron variant was less clear. Antibody risings were found to be positively associated with pneumonia, certain underlying conditions (obesity, hypertension, dyslipidemia, and diabetes mellitus), and age ≥ 60 years. Delta variant infections were associated with forgetfulness, hair loss, and headache during the 1-year post-infection period. Females were more likely to experience hair loss, forgetfulness, and joint pain, while older age was associated with joint pain. Conclusions: This study enhances our understanding of SARS-CoV-2 infections in Thais, particularly concerning the Delta and Omicron variants. The findings can inform public health planning and response strategies for future outbreaks of SARS-CoV-2 or other emerging viral diseases. [ABSTRACT FROM AUTHOR]

Background: The global pandemic caused by SARS‐CoV‐2 has underlined the significance of strict genomic surveillance to track virus evolution and the possible emergence of new variants, particularly in densely populated countries like Bangladesh. This study outlines a strategic framework of genomic surveillance to track the evolution of the virus in Bangladesh between June 2021 and December 2022 through the National SARS‐CoV‐2 Variant Surveillance (NSVS) program involving collaboration across 4 major institutes and 13 hospitals nationwide. Methods: We aimed to capture the variants of SARS‐CoV‐2 throughout the country utilizing standardized procedures, modern sequencing technology, and stringent quality control, promoting data accuracy and the timely detection of new variants of concern. We sequenced over 2200 genomes, documenting the prevalence of the Delta variant initially, followed by the emergence of Omicron variants BA.1, BA.2, BA.5, and XBB, each affecting transmission rates and vaccine efficacy differently. Results: The clinical manifestations of the variants differed, with some symptoms occurring more frequently in Delta cases and vice versa. Vaccinated individuals were more affected by Omicron cases compared to Delta cases. These variants were responsible for two major COVID‐19 waves in the country, each with significant clinical effects. Phylogenetic analyses placed the local SARS‐CoV‐2 variants within a global context, indicating the Delta variant likely entered from India and Omicron from Europe. Conclusion: This research highlights the significance of collaborative surveillance strategies for guiding public health choices and the critical role of genomic analysis in monitoring virus evolution, shaping targeted pandemic responses. Bangladesh's contributions significantly enhance global insight into COVID‐19's genomic evolution. [ABSTRACT FROM AUTHOR]

Individuals with chronic lung disease (CLD) are more susceptible to respiratory viral infections; however, significant heterogeneity exists in the literature on CLD and COVID-19 outcomes. Data are lacking on outcomes with newer variants (eg, Omicron) and in vaccinated and boosted populations. What are the outcomes of SARS-CoV-2 infection in individuals with CLD during Delta and Omicron transmission in a highly vaccinated and boosted population-based cohort? Outcomes of Delta and Omicron SARS-CoV-2 infection in a highly vaccinated and boosted cohort of adult Singaporeans with CLD (including asthma, COPD, bronchiectasis, and pulmonary fibrosis) were contrasted against matched population control participants. Calendar time-scale Cox regressions were used to compare risk of infection, COVID-19-related hospitalizations, and severe COVID-19 disease, adjusting for sociodemographic factors and comorbidities. Overall, 68,782 individual patients with CLD and 534,364 matched population control participants were included. By the end of the Omicron wave, 92.7% of patients with CLD were boosted. Compared with control participants, patients with CLD showed higher risk of SARS-CoV-2 infection, COVID-19-related hospitalization, and severe COVID-19 during both the Delta wave (infection: adjusted hazards ratio [aHR], 1.22 [95% CI, 1.17-1.28]; hospitalization: aHR, 1.76 [95% CI, 1.61-1.92]; severe COVID-19: aHR, 1.75 [95% CI, 1.50-2.05]) and Omicron wave (infection: aHR, 1.15 [95% CI, 1.14-1.17]; hospitalization: aHR, 1.82 [95% CI, 1.74-1.91]; severe COVID-19: aHR, 2.39 [95% CI, 2.18-2.63]). During Omicron, significantly higher risk of infection, hospitalization, and severe COVID-19 was observed among patients with asthma (severe COVID-19: aHR, 1.31 [95% CI, 1.10-1.55]) and COPD (severe COVID-19: aHR, 1.36 [95% CI, 1.12-1.66]) compared with control participants. Severe exacerbation (requiring hospitalization) in the preceding year was associated with higher risk of poorer outcomes (Delta, severe COVID-19: aHR, 9.84 [95% CI, 6.33-15.28]; Omicron, severe COVID-19: aHR, 19.22 [95% CI, 15.35-24.06]). Risk was attenuated in the boosted group, with numerically lower HRs against hospitalization and severe COVID-19 in the four-dose group compared with the three-dose group. Increased risk of COVID-19-related hospitalization and severe COVID-19 was observed among patients with CLD compared with matched population control participants during Delta and Omicron predominance. Boosting attenuated serious COVID-19 outcomes. [ABSTRACT FROM AUTHOR]

Background: Oral candidiasis has been documented in patients with SARS-CoV-2 infection, with varying prevalence rates across geographic regions and patient demographics. This study aimed to ascertain the incidence, characteristics, and risk factors associated with the development of oral candidiasis in patients hospitalized for SARS-CoV-2 infection in a tertiary infectious diseases hospital in Romania. Methods: A retrospective analysis was conducted on adult patients hospitalized between March 2020 and December 2022 with moderate or severe forms of SARS-CoV-2 infection, for whom a culture of lingual scrapings for Candida spp. was performed. Results: A total of 294 patients were deemed eligible for inclusion in the analysis, with an incidence rate of oral candidiasis of 17.0%. The incidence of oral candidiasis was 4.2 times higher in patients with severe forms of SARS-CoV-2 infection compared to those with moderate forms. Patients with a diagnosis of COVID-19 and oral candidiasis were more likely to receive antibiotics (98.0% vs. 86.1%, p = 0.017) and corticosteroids (100% vs. 83.6%, p = 0.003) than those without oral candidiasis. These findings were associated with a 19% higher relative risk of developing oral candidiasis for patients who received corticosteroid therapy compared to those who did not, and a 13% higher relative risk for those who were administered antibiotics compared to those who were not. The presence of respiratory insufficiency increased the odds of oral candidiasis association 4.7-fold (88.0% vs. 61.1%, p < 0.001). Conclusions: Although the data have been analyzed retrospectively, we have shown that individuals with severe forms of COVID-19 exhibited an elevated risk of developing oral candidiasis. The administration of antibiotics and corticosteroids was identified as a positive predictor for the development of oral candidiasis. The data presented here suggest that a key aspect of the therapeutic management of patients with SARS-CoV-2 infection should include the implementation of preventive measures to minimize the risk of secondary fungal infections. [ABSTRACT FROM AUTHOR]

Naumure Multipurpose Project (NMP) featuring a 169 m high Concrete Face Rock Filled Dam (CFRD) is the proposed reservoir project in the West Rapti River with an installed capacity of 218.34 MW. Most of the rivers in Nepal carry significant sediment loads that will consequently catalyze reservoir sedimentation. This phenomenon prevails as the primary factor in reducing reservoirs useful life, making ineffective for both flood control and hydroelectricity generation. Ultimately, such process of sedimentation has adverse impacts on projects economic feasibility and long-term sustainability. Therefore, the objective of this research was to examine the expected sediment deposition pattern in the NMP reservoir throughout its operational period by employing 1D HEC-RAS model to simulate the sedimentation process. The model was simulated for 10, 20, 30, 40 and 50 years. Yang's equation as a sediment transport function, Active layer as a bed sorting method and Toffaleti as a fall velocity method were best suited for the river reach. The delta deposition was formed between 11 km and 22 km upstream of the dam region in the Jhimruk river, with the sediment deposition depth reaching peaks of about 23 m, 38 m, 39 m, 41 m and 49 m in 10, 20, 30, 40 and 50 years, respectively. Similarly, the delta deposition was formed between 13 km and 33 km upstream of dam region in the Madi river, with the sediment deposition depth reaching peaks of about 47 m, 62 m, 60 m, 68 m and 75 m in 10, 20, 30, 40 and 50 years respectively. Headcutting of delta deposition occurred between 20 and 30 year due to high flood during low stage of reservoir. Furthermore, the study revealed that about 6.22%, 11.61%, 15.94%, 22.96% and 25.65% of the storage capacity of NMP reservoir will be depleted in 10, 20, 30, 40 and 50 years respectively. [ABSTRACT FROM AUTHOR]

In recent years, extensive exploration has contributed to significant advancements in the geological formations of the Kuqa Depression. In particular, the Paleogene Kumugeliemu Formation exhibits the development of expansive bedded evaporites. The combination of red sandstone, red mudstone, and gypsum-salt layers holds immense potential as a reservoir and cap association, thereby offering promising prospects for oil and gas exploration. However, our understanding of the sedimentary system and model governing this formation remains limited, impeding progress in the field of oil and gas exploration. To address this gap, this study delved into a detailed examination of the stratigraphy, depositional system, and model of the Kumugeliemu Formation through the application of core samples, logging data, and seismic analyses. The primary objective of this study was to establish a comprehensive theoretical foundation for future oil and gas exploration efforts targeting the Kumugeliemu Formation. The findings revealed a distinct division of the Kumugeliemu Formation into two 3rd order sequences, each characterized by a lowstand systems tract, transgressive systems tract, and highstand systems tract. Moreover, all systems tracts were further subdivided into 14 parasequence sets. During the depositional period of the Kumugeliemu Formation, alluvial fan, delta, and salt lake deposition systems developed from the periphery to the central region of the Kuqa Depression. The alluvial fan mainly exhibited braided channel sedimentary microfacies, whereas the delta region indicated plain distributary channels, submerged distributary channels, and interdistributary sedimentary microfacies. The salt lake area is characterized by shore-shallow lacustrine mud, beach-bar, salt mud flat, and salt flat sedimentary microfacies. Throughout the deposition of the Kumugeliemu Formation, the climate of the Kuqa Depression oscillated between arid and humid. During arid periods, the depression experienced diminished water body extent, heightened salinity levels, and extensive distribution of salt and salt mud flats within the basin, with alluvial fans and delta deposits primarily confined to the basin margins. Conversely, during the humid period, the depression experienced an expansion in the extent of the water bodies, leading to a decrease in salinity levels. The distribution of salt flat and salt mud flat deposits within the basin diminished, whereas alluvial fan and delta deposits advanced extensively across the basin. The establishment and spatial arrangement of the sedimentary system within the Kumugeliemu Formation were governed by a complex interplay of certain factors, such as the semi-closed paleotectonic pattern, paleoclimatic conditions of both dry and wet alternation, and the salt source supply brought by the transgression of the Paleo-Tethys Ocean. The findings of this study offer not only a valuable reference framework for the prospective exploration of hydrocarbon resources within the Kumugeliemu Formation of the Kuqa Depression but also potential insights into the evolution of similar depressions in other basins. [ABSTRACT FROM AUTHOR]

Background: In previous studies, there was an increase in mortality with secondary coinfections in all COVID-19 variants. However, no prior study has explored the association of coinfection with outcomes of hospitalized patients among the COVID-19 variants (Alpha, Delta, and Omicron). Methods: This observational cohort study involved 21,186 patients hospitalized with COVID-19 in 25 hospitals in Texas. Patients were divided into groups by surges of COVID-19: Alpha (November 1, 2020–February 10, 2021), Delta (July 10, 2021–October 14, 2021), and Omicron (December 21, 2021–March 3, 2022). Data were collected from electronic health records using methodology from the Viral Respiratory Illness Universal Study COVID-19 registry (NCT04323787) of COVID-19 hospitalizations. Multivariable Cox-proportional hazard regression model assessed the adjusted effect of different surge periods on mortality. Results: Bacterial coinfections varied among hospitalization surges associated with Alpha (8.5%), Delta (11.7%), and Omicron (11.9%) variants. Adjusted analyses showed a higher 30-day and 90-day mortality in all variants when coinfections were present compared with isolated COVID-19 infection. In particular, 30-day and 90-day mortality were significantly worse with Delta compared to Alpha and Omicron. Conclusions: All variants were associated with a higher mortality when bacterial coinfections were present. Delta was associated with a higher risk-adjusted mortality at 30 days and thereafter. [ABSTRACT FROM AUTHOR]

The northern inlet channel to Jezero crater (Sava Vallis) terminates in a fan‐shaped depositional feature, part of which blends into the separate well‐known western fan delta that is the field site for the Mars 2020 mission's Perseverance rover. Jezero's northern fan potentially represents either a second fan delta within the crater or a distal portion of the western fan. To constrain the fluvial and sedimentological history of Jezero and place the rover's in situ observations in proper geologic context, we photogeologically map the northern fan deposits at a larger mapping scale than previous studies, using ground‐based imaging from the Perseverance rover for context. Fifteen map units are identified using HiRISE‐based interpretations of geologic characteristics and inferred processes as well as crosscutting relative age relationships. Mapped units are also defined based on orbital data from CRISM and THEMIS to assess their compositional signatures. We interpret the northern fan deposits as older than the uppermost blocky unit in the western fan delta, suggesting that they were deposited contemporaneously with or prior to the deposition of the western fan, and under similar climate conditions. The eastern portion of the northern fan deposits shows evidence of fluvial deposition from Sava Vallis, while part of its western side could represent a distal part of the western fan delta. We synthesize our interpretations to present scenarios for the deposition of the northern and western fans, which can help constrain the history of both watersheds and place it into context within the broader Isidis basin region. Plain Language Summary: The Mars 2020 Perseverance rover has primarily focused on using its scientific instruments to study the delta along Jezero crater's western margin. But there are fan‐shaped features that appear to originate from both the crater's western and northern channels ‐ Neretva Vallis and Sava Vallis, respectively. In this project, we compile orbital images, spectroscopy data sets, and images taken by the rover's Mastcam‐Z instrument to investigate whether the northern fan originated from the northern channel or is an outlying part of the western delta. Based on these observations and the geologic map created using them, we show that the northern fan deposits are older than the uppermost unit mapped in the western delta. We also demonstrate how the western portion of the northern fan deposits could be an outer part of the western delta, while the eastern portion may preserve material from Sava Vallis. We show that some units across the northern and western fans are the same or similar, making this work useful as the rover's mission continues. Finally, we present scenarios that could lead to what we see in Jezero today, helping us to understand the potential history of this area and the relationship between the northern and western watersheds. Key Points: Deposition of Jezero crater's northern fan predates that of its western fan blocky material—the western delta's uppermost surficial unitThe northern fan shows evidence of deposition from Sava Vallis, but part of its western region could be a distal part of the western deltaThe stratigraphic and depositional hypotheses presented provide context for the Mars 2020 mission and help constrain the history of both watersheds [ABSTRACT FROM AUTHOR]

BackgroundF-8-coil repetitive transcranial magnetic stimulation (rTMS) and H-1-coil deep repetitive transcranial magnetic stimulation (dTMS) have been indicated for the treatment of major depressive disorder (MDD) in adult patients by applying different treatment protocols. Nevertheless, the evidence for long-term electrophysiological alterations in the cortex following prolonged TMS interventions, as assessed by quantitative electroencephalography (qEEG), remains insufficiently explored. This study aims to demonstrate the qEEG-based distinctions between rTMS and dTMS in the management of depression and to evaluate the potential correlation between the electrophysiological changes induced by these two distinct TMS interventions and the clinical improvement in depressive and anxiety symptoms.MethodsA total of 60 patients diagnosed with treatment resistant depression received rTMS (n = 30) or dTMS (n = 30) along with their usual treatments in Kemal Arıkan Psychiatry Clinic. All the participants underwent resting-state qEEG recording before and at the end of 30 sessions of TMS treatment. The significant qEEG changes were then tested for their correlation with the improvement in depression and anxiety.ResultsAfter the course of rTMS and dTMS a considerable reduction is seen in the severity of depression and anxiety. Although improvements in depression and anxiety were observed in both TMS groups, specific neural activity patterns were associated with better outcomes in depression. Patients who exhibited lower alpha activity in the left fronto-central region and higher gamma activity in the right prefrontal region following rTMS showed more significant improvements in depression symptoms. Similarly, those whose beta activity increased in the left prefrontal region but decreased in the right prefrontal region after rTMS tended to have greater reductions in depression and anxiety severity. For patients in the dTMS group, those who demonstrated a decrease in left temporal theta activity after treatment were more likely to experience a substantial improvement in depression severity.ConclusionFollowing 30 sessions of rTMS with a F8 coil and dTMS with an H1 coil, notable alterations in qEEG activity with clinical significance were discerned. The persistence of these changes should be investigated in the subsequent follow-up period.