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3. Systematic review: Patient‐related, microbial, surgical, and histopathological risk factors for endoscopic post‐operative recurrence in patients with Crohn's disease.

Author

Bak, Michiel T. J., Demers, Karlijn, Hammoudi, Nassim, Allez, Matthieu, Silverberg, Mark S., Fuhler, Gwenny M., Parikh, Kaushal, Pierik, Marieke J., Stassen, Laurents P. S., van der Woude, C. Janneke, Doukas, Michail, van Ruler, Oddeke, and de Vries, Annemarie C.

Subjects
*CROHN'S disease, *PREOPERATIVE risk factors, *DISEASE risk factors, *INTESTINAL diseases, *ONLINE databases
Abstract

Summary: Background: Risk stratification for endoscopic post‐operative recurrence (ePOR) in Crohn's disease (CD) is required to identify patients who would benefit most from initiation of prophylactic medication and intensive monitoring of recurrence. Aims: To assess the current evidence on patient‐related, microbial, surgical and histopathological risk factors for ePOR in patients with CD after ileocolic (re‐)resection. Methods: Multiple online databases (Embase, MEDLINE, Web of Science and Cochrane Library) were searched up to March 2024. Studies with reported associations of patient‐related, microbial, surgical and/or histopathological factors for ePOR (i.e., Rutgeerts' score ≥i2 or modified Rutgeerts' score ≥i2a) were included. The risk of bias was assessed with the Newcastle‐Ottawa Scale for observational cohort studies and case‐control studies. Results: In total, 47 studies were included (four RCTs, 29 cohort studies, 12 case–control studies, one cross‐sectional study and one individual participant data meta‐analysis) including 6006 patients (median sample size 87 patients [interquartile range 46–170]). Risk of bias assessment revealed a poor quality in 41% of the studies. An association was reported in multiple studies of ePOR with active smoking at and post‐surgery, male sex and prior bowel resection. A heterogeneous association with ePOR was reported for other risk factors included in the current guidelines (penetrating disease, perianal disease, younger age, extensive small bowel disease and presence of granulomas in the resection specimen or myenteric plexitis in the resection margin), and other patient‐related, microbial, surgical and histopathological factors. Conclusion: Risk factors for ePOR in international guidelines are not consistently reported as risk factors in current literature except for active smoking and prior bowel resection. To develop evidence‐based, personalised strategies, large prospective studies are warranted to identify risk factors for ePOR. Validation studies of promising (bio)markers are also required. [ABSTRACT FROM AUTHOR]

Published
2024
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5. Scoping review on health-related physical fitness in patients with inflammatory bowel disease:Assessment, interventions, and future directions

Author

Demers, Karlijn, Bak, Michiel T.J., Bongers, Bart C., de Vries, Annemarie C., Jonkers, Daisy M.A.E., Pierik, Marieke J., Stassen, Laurents P.S., Demers, Karlijn, Bak, Michiel T.J., Bongers, Bart C., de Vries, Annemarie C., Jonkers, Daisy M.A.E., Pierik, Marieke J., and Stassen, Laurents P.S.

Abstract

BACKGROUND:Reaching the Selecting Therapeutic Targets in Inflammatory Bowel Disease-II (STRIDE-II) therapeutic targets for inflammatory bowel disease (IBD) requires an interdisciplinary approach. Lifestyle interventions focusing on enhancing and preserving health-related physical fitness (HRPF) may aid in improving subjective health, decreasing disability, or even controlling inflammation. However, ambiguity remains about the status and impact of HRPF (i.e. body composition, cardiorespiratory fitness, muscular strength, muscular endurance, and flexibility) in IBD patients, hindering the development of physical activity and physical exercise training guidelines. AIM:To review HRPF components in IBD patients and the impact of physical activity and physical exercise training interventions on HRPF. METHODS:A systematic search in multiple databases was conducted for original studies that included patients with IBD, assessed one or more HRPF components, and/or evaluated physical activity or physical exercise training interventions. RESULTS:Sixty-eight articles were included. No study examined the complete concept of HRPF, and considerable heterogeneity existed in assessment methods, with frequent use of non-validated tests. According to studies that used gold standard tests, cardiorespiratory fitness seemed to be reduced, but findings on muscular strength and endurance were inconsistent. A limited number of studies that evaluated physical activity or physical exercise training interventions reported effects on HRPF, overall showing a positive impact. CONCLUSION:This review revealed a gap in the literature regarding the accurate assessment of HRPF in patients with IBD and highlighted important methodological limitations of studies that evaluated physical activity or physical exercise training interventions. Future well-designed studies are required to determine the optimal

Published
2023

9. Mo1804 IMAGING-BASED PREOPERATIVE BODY COMPOSITION IS ASSOCIATED WITH THE RISK OF POSTOPERATIVE COMPLICATIONS AND POSTOPERATIVE ENDOSCOPIC RECURRENCE IN PATIENTS WITH CROHN'S DISEASE

Author

Bak, Michiel T., Demers, Karlijn, van Ruler, Oddeke, Pierik, Marie J., van der Bilt, Jarmila D.W., Romberg-Camps, Mariëlle, Dijkstra, Gerard, Duijvestein, Marjolijn, van der Marel, Sander, Maljaars, Jeroen, Buskens, Christianne J., Bakers, Frans C., van Dijk, David P., Brecheisen, Ralph, Bongers, Bart C., van Rossum, Elisabeth F., de Witte, Dennis, Jansen, Sita, Jharap, Bindia, Horje, Carmen S. Horjus Talabur, Van Schaik, Fiona, West, Rachel, De Boer, Nanne, Van Der Woude, Christien Janneke, Stassen, Laurents P., and De Vries, Annemarie C.

Published
2024
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